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Archive for the ‘Ubiquitin’ Category


Lesson 4 Cell Signaling And Motility: G Proteins, Signal Transduction: Curations and Articles of reference as supplemental information: #TUBiol3373

Curator: Stephen J. Williams, Ph.D.

Below please find the link to the Powerpoint presentation for lesson #4 for #TUBiol3373.  The lesson first competes the discussion on G Protein Coupled Receptors, including how cells terminate cell signals.  Included are mechanisms of receptor desensitization.  Please NOTE that desensitization mechanisms like B arrestin decoupling of G proteins and receptor endocytosis occur after REPEATED and HIGH exposures to agonist.  Hydrolysis of GTP of the alpha subunit of G proteins, removal of agonist, and the action of phosphodiesterase on the second messenger (cAMP or cGMP) is what results in the downslope of the effect curve, the termination of the signal after agonist-receptor interaction.

 

Click below for PowerPoint of lesson 4

Powerpoint for lesson 4

 

Please Click below for the papers for your Group presentations

paper 1: Membrane interactions of G proteins and other related proteins

paper 2: Macaluso_et_al-2002-Journal_of_Cellular_Physiology

paper 3: Interactions of Ras proteins with the plasma membrane

paper 4: Futosi_et_al-2016-Immunological_Reviews

 

Please find related article on G proteins and Receptor Tyrosine Kinases on this Open Access Online Journal

G Protein–Coupled Receptor and S-Nitrosylation in Cardiac Ischemia and Acute Coronary Syndrome

Action of Hormones on the Circulation

Newer Treatments for Depression: Monoamine, Neurotrophic Factor & Pharmacokinetic Hypotheses

VEGF activation and signaling, lysine methylation, and activation of receptor tyrosine kinase

 

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Biological Pathways

Reporter: Aviva Lev-Ari, PhD, RN

 

Biological Pathways

View larger

SOURCE

https://www.genome.gov/27530687/biological-pathways-fact-sheet/

Figure 3: Examples of biological pathways that are regulated by selective mRNA export.

FromControl of mammalian gene expression by selective mRNA export

Nature Reviews Molecular Cell Biology
16,
431–442
(2015)
doi:10.1038/nrm4010

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Understanding Autophagy to Enhance Clinical Discovery: The 2016 Dr. Paul Janssen Award Symposium, September 22, 2016 | 8:00 AM – 2:15 PM, The New York Academy of Medicine, 1216 Fifth Avenue New York, NY 10029

Reporter: Aviva Lev-Ari, PhD, RN

 

Understanding Autophagy to Enhance Clinical Discovery: The 2016 Dr. Paul Janssen Award Symposium

Thursday, September 22, 2016 | 8:00 AM – 2:15 PM
The New York Academy of Medicine

Presented by the Dr. Paul Janssen Award for Biomedical Research and the New York Academy of Sciences

This symposium will honor Dr. Yoshinori Ohsumi, who will reflect on his initial work on the key players in autophagy, and share his vision for future advancements in the field. Following his award lecture, fellow prominent scientists at the forefront of autophagy research will discuss emerging concepts and technologies.

AGENDA

 

Preliminary Symposium Agenda

* Presentation times are subject to change.


Thursday, September 22, 2016

8:00 AM Registration and Breakfast
9:00 AM Welcome and Introductory Remarks
Anthony Shih, MD, MPH, The New York Academy of Medicine
Representative, Johnson & Johnson
Brooke Grindlinger, PhD, The New York Academy of Sciences

Session I: Elucidating the Underlying Cellular Processes of Autophagy

9:15 AM 2016 Dr. Paul Janssen Award for Biomedical Research Announcement
Representative, Janssen Research & Development
9:30 AM Dr. Paul Janssen Award for Biomedical Research Lecture
Uncovering the Key Molecular and Cellular Components in Autophagy
Yoshinori Ohsumi, PhD, Tokyo Institute of Technology
10:20 AM Coffee and Networking Break

Session II: Understanding the Molecular Landscape of Autophagy: From Basic Mechanisms to Human Health

Session Chair: Representative, The New York Academy of Sciences

10:50 AM Potential Therapeutic Targets in Autophagy
Beth Levine, MD, University of Texas Southwestern Medical Center, Howard Hughes Medical Institute (HHMI)
11:20 AM Autophagy in Cell Survival and Cell Death
Eric H. Baehrecke, PhD, University of Massachusetts Medical School
11:50 AM The Role of Chaperone-mediated Autophagy in Human Pathogenesis
Ana Maria Cuervo, MD, PhD, Albert Einstein College of Medicine
12:20 PM Title to Be Announced
Matthias Versele, PhD, Janssen Research & Development
12:50 PM Panel Discussion: The Future of Autophagy Research

Panelists:
Yoshinori Ohsumi, PhD, Tokyo Institute of Technology
Eric H. Baehrecke, PhD, University of Massachusetts Medical School
Ana Maria Cuervo, MD, PhD, Albert Einstein College of Medicine
Beth Levine, MD, University of Texas Southwestern Medical Center, Howard Hughes Medical Institute (HHMI)

* Additional Panelists to Be Announced

1:15 PM Luncheon
2:15 PM Adjourn

SOURCE

http://www.nyas.org/Events/Detail.aspx?cid=f5480228-c7ed-4f29-80bf-cc42b503e703

 

Other articles On and related to AUTOPHAGY published on this Open Access Online Scientific Journal include the following:

Autophagy

Writer and Curator: Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/04/03/autophagy/

 

Autophagy-Modulating Proteins and Small Molecules Candidate Targets for Cancer Therapy: Commentary of Bioinformatics Approaches

Author and Curator: Larry H Bernstein, MD, FCAP and Article Architect: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2014/09/18/autophagy-modulating-proteins-and-small-molecules-candidate-targets-for-cancer-therapy-commentary-of-bioinformatics-approaches/

 

A Curated Census of Autophagy-Modulating Proteins and Small Molecules Candidate Targets for Cancer Therapy 

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2014/09/14/a-curated-census-of-autophagy-modulating-proteins-and-small-molecules-candidate-targets-for-cancer-therapy/

 

Autophagy: Selective articles by Larry H. Bernstein, MD, FCAP

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2014/05/01/autophagy-selective-articles-by-larry-h-bernstein-md-fcap/

 

 

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