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Lesson 4 Cell Signaling And Motility: G Proteins, Signal Transduction: Curations and Articles of reference as supplemental information: #TUBiol3373

Posted in Biochemical pathways, Biological Networks, Brain Basis of Emotion, Ca2+ triggered activation, Calcium, Calcium Signaling, Cancer - General, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Cell Biology, Signaling & Cell Circuits, Cerebrovascular and Neurodegenerative Diseases, Enzymes and isoenzymes, Kinase, Metabolism, Phosphatase, Phosphorylase, tyrosine decarboxylases, Ubiquitin, tagged arrestins, C-Protein Coupled Receptors (GPCRs), calcium signaling, CAMP, cGMP, G protein, G Protein coupling, G protein-coupled receptor, Insulin, JAK, Jak-STAT pathway, PKC, receptor desensitization, Receptor tyrosine kinases, receptor uncoupling, Second messenger system, tyrosine receptors on February 21, 2019| Leave a Comment »

Lesson 4 Cell Signaling And Motility: G Proteins, Signal Transduction: Curations and Articles of reference as supplemental information: #TUBiol3373

Curator: Stephen J. Williams, Ph.D.

Updated 7/15/2019

Below please find the link to the Powerpoint presentation for lesson #4 for #TUBiol3373. The lesson first competes the discussion on G Protein Coupled Receptors, including how cells terminate cell signals. Included are mechanisms of receptor desensitization. Please NOTE that desensitization mechanisms like B arrestin decoupling of G proteins and receptor endocytosis occur after REPEATED and HIGH exposures to agonist. Hydrolysis of GTP of the alpha subunit of G proteins, removal of agonist, and the action of phosphodiesterase on the second messenger (cAMP or cGMP) is what results in the downslope of the effect curve, the termination of the signal after agonist-receptor interaction.

Click below for PowerPoint of lesson 4

Powerpoint for lesson 4

Please Click below for the papers for your Group presentations

paper 1: Membrane interactions of G proteins and other related proteins

paper 2: Macaluso_et_al-2002-Journal_of_Cellular_Physiology

paper 3: Interactions of Ras proteins with the plasma membrane

paper 4: Futosi_et_al-2016-Immunological_Reviews