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The Nobel Prize in Chemistry 2020: Emmanuelle Charpentier & Jennifer A. Doudna

Posted in Award Nominations, Cell Biology, CRISPR alternative for editing genes without cutting, CRISPR applied to Human Germ Line, CRISPR/Cas9 & Gene Editing, DNA repair, Gene Therapy & Gene Editing Development, Genetics & Innovations in Treatment, Genetics & Pharmaceutical, Genome Biology, Interviews with Key Opinion Leaders (KOLs), Molecular Genetics & Pharmaceutical, Nobel Prize WInners, Stem Cells for Regenerative Medicine, tagged CRISPR –Cas9 system for genetic engineering, CRISPR Biology • Genome Editing • Gene Drives • DNA Repair • Model and Industrial Organisms • Technology Development • Stem Cells/Cancer • Genome-Wide Screens, CRISPR-based gene editing, CRISPR-Cas9, CRISPR/Cas and base editing, gene editing, gene editing technology platform, Jennifer Doudna, nobel leureates, Nobel Prize, Nobel Prize in Chemistry, Stanford University on October 8, 2020| 1 Comment »

The Nobel Prize in Chemistry 2020: Emmanuelle Charpentier & Jennifer A. Doudna

Reporters: Stephen J. Williams, Ph.D. and Aviva Lev-Ari, PhD, RN

 

UPDATED on 11/12/2020

Harvard’s Jack Szostak congratulates former advisee Jennifer Doudna

BY Alvin Powell, Harvard Staff Writer

DATE October 8, 2020

 

It was a toast from one Nobel laureate to another, sweetened by the pride of a mentor to a prized student.

When Jennifer Doudna Ph.D. ’89 was honored on Wednesday with the Nobel Prize in chemistry for her work on the CRISPR gene-editing technique, she became the second person to gain such an honor from the lab of Jack Szostak, a genetics professor at Harvard Medical School and Massachusetts General Hospital, and professor of chemistry and chemical biology at Harvard’s Faculty of Arts and Sciences.

Szostak, who won the Nobel Prize in physiology or medicine in 2009 for work on how telomere caps keep the body’s chromosomes from breaking down, advised Doudna’s doctoral work on RNA and on Wednesday raised a glass in honor of Doudna, now at the University of California, Berkeley. In a tweet, Szostak expressed his delight at seeing someone he once guided through her early scientific steps soar to science’s highest reaches:

Doudna received the prize together with Emmanuelle Charpentier, for their work discovering and developing CRISPR as a precise gene-editing tool. In just the eight years since the pair announced their discovery the use of the technique has rapidly spread to a host of fields, allowing researchers to alter the code of life and develop resistant crops, new medical therapies, and even anticipate curing inherited diseases.

SOURCE

https://news.harvard.edu/gazette/story/2020/10/nobel-laureate-jack-szostak-toasts-former-student-jennifer-doudna/?utm_source=newsletter&utm_medium=email&utm_campaign=events&utm_content=haa_ade_all_alumni_2020-11-12

 

UPDADTED on 11/2/2020

• The New York Times (subscription content): “Nobel Prize in Chemistry Awarded to Two Scientists for Work on Genome Editing”
• The New York Times (subscription content): “Opinion: This Year’s Nobel Prize in Chemistry Honors a Revolution”
• JAMA: “The Case for Remedial Germline Editing — The Long-term View“
• The Wall Street Journal (subscription content): “CRISPR Gene Editing Can Lead to Big Mistakes in Human Embryos”

 

Announcement of the Nobel Prize in Chemistry 2020

Live webcast from the press conference where the Royal Swedish Academy of Sciences will announce the Nobel Prize in Chemistry 2020.

 

 

 

The Nobel Prize

 

@NobelPrize

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

 

 

5:47 AM · Oct 7, 2020

 

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The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.” The announcement was made at the Royal Swedish Academy of Sciences in Stockholm. #nobelprize

 

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2020 to

Emmanuelle Charpentier
Max Planck Unit for the Science of Pathogens, Berlin, Germany

Jennifer A. Doudna
University of California, Berkeley, USA

“for the development of a method for genome editing”

Genetic scissors: a tool for rewriting the code of life

Emmanuelle Charpentier and Jennifer A. Doudna have discovered one of gene technology’s sharpest tools: the CRISPR/Cas9 genetic scissors. Using these, researchers can change the DNA of animals, plants and microorganisms with extremely high precision. This technology has had a revolutionary impact on the life sciences, is contributing to new cancer therapies and may make the dream of curing inherited diseases come true.

Researchers need to modify genes in cells if they are to find out about life’s inner workings. This used to be time-consuming, difficult and sometimes impossible work. Using the CRISPR/Cas9 genetic scissors, it is now possible to change the code of life over the course of a few weeks.

“There is enormous power in this genetic tool, which affects us all. It has not only revolutionised basic science, but also resulted in innovative crops and will lead to ground-breaking new medical treatments,” says Claes Gustafsson, chair of the Nobel Committee for Chemistry.

As so often in science, the discovery of these genetic scissors was unexpected. During Emmanuelle Charpentier’s studies of Streptococcus pyogenes, one of the bacteria that cause the most harm to humanity, she discovered a previously unknown molecule, tracrRNA. Her work showed that tracrRNA is part of bacteria’s ancient immune system, CRISPR/Cas, that disarms viruses by cleaving their DNA.

Charpentier published her discovery in 2011. The same year, she initiated a collaboration with Jennifer Doudna, an experienced biochemist with vast knowledge of RNA. Together, they succeeded in recreating the bacteria’s genetic scissors in a test tube and simplifying the scissors’ molecular components so they were easier to use.

In an epoch-making experiment, they then reprogrammed the genetic scissors. In their natural form, the scissors recognise DNA from viruses, but Charpentier and Doudna proved that they could be controlled so that they can cut any DNA molecule at a predetermined site. Where the DNA is cut it is then easy to rewrite the code of life.

Since Charpentier and Doudna discovered the CRISPR/Cas9 genetic scissors in 2012 their use has exploded. This tool has contributed to many important discoveries in basic research, and plant researchers have been able to develop crops that withstand mould, pests and drought. In medicine, clinical trials of new cancer therapies are underway, and the dream of being able to cure inherited diseases is about to come true. These genetic scissors have taken the life sciences into a new epoch and, in many ways, are bringing the greatest benefit to humankind.

Illustrations

The illustrations are free to use for non-commercial purposes. Attribute ”© Johan Jarnestad/The Royal Swedish Academy of Sciences”

Illustration: Using the genetic scissors (pdf)
Illustration: Streptococcus’ natural immune system against viruses:CRISPR/Cas9 pdf)
Illustration: CRISPR/Cas9 genetic scissors (pdf)

Read more about this year’s prize

Popular information: Genetic scissors: a tool for rewriting the code of life (pdf)
Scientific Background: A tool for genome editing (pdf)

Emmanuelle Charpentier, born 1968 in Juvisy-sur-Orge, France. Ph.D. 1995 from Institut Pasteur, Paris, France. Director of the Max Planck Unit for the Science of Pathogens, Berlin, Germany.

Jennifer A. Doudna, born 1964 in Washington, D.C, USA. Ph.D. 1989 from Harvard Medical School, Boston, USA. Professor at the University of California, Berkeley, USA and Investigator, Howard Hughes Medical Institute.

SOURCE

https://www.nobelprize.org/prizes/chemistry/2020/press-release/

 

Nobel Prize in Chemistry awarded to scientists who discovered CRISPR gene editing tool for ‘rewriting the code of life’

By Emma Reynolds and Katie Hunt, CNN

Updated 9:54 AM ET, Wed October 7, 2020

 

Emmanuelle Charpentier explains CRISPR Cas9 gene editing (2016)

 

(CNN)The Nobel Prize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna for the development of a method for genome editing.

They discovered one of gene technology’s sharpest tools: the CRISPR/Cas9 genetic scissors. Using these, researchers can change the DNA of animals, plants and micro-organisms with extremely high precision.

Before announcing the winners on Wednesday, Göran K. Hansson, secretary-general for the Royal Swedish Academy of Sciences, said that this year’s prize was about “rewriting the code of life.”

 

The American biochemist Jennifer A. Doudna (left) and French microbiologist Emmanuelle Charpentier, pictured together in 2016.

The CRISPR/Cas9 gene editing tools have revolutionized the molecular life sciences, brought new opportunities for plant breeding, are contributing to innovative cancer therapies and may make the dream of curing inherited diseases come true, according to a press release from the Nobel committee.

 

 

There have also been some ethical concerns around the CRISPR technology, however.

Charpentier, a French microbiologist, and Doudna, an American biochemist, are the first women to jointly win the Nobel Prize in Chemistry, and the sixth and seventh women to win the chemistry prize.

close dialog

SOURCE

https://www.cnn.com/2020/10/07/health/nobel-prize-2020-winner-chemistry-scn-intl/index.html

 

Jennifer Doudna wins 2020 Nobel Prize in chemistry

By Robert Sanders, UC BerkeleyWednesday, October 7, 2020

 

First Day in a Nobel Life: Jennifer Doudna

12,365 views

•Oct 7, 2020

 

UC Berkeley

 

Scenes from day that UC Berkeley Professor Jennifer Doudna won the Nobel Prize For the full story, visit: https://news.berkeley.edu/2020/10/07/… University of California, Berkeley, biochemist Jennifer Doudna today won the 2020 Nobel Prize in Chemistry, sharing it with colleague Emmanuelle Charpentier for the co-development of CRISPR-Cas9, a genome editing breakthrough that has revolutionized biomedicine. CRISPR-Cas9 allows scientists to rewrite DNA — the code of life — in any organism, including human cells, with unprecedented efficiency and precision. The groundbreaking power and versatility of CRISPR-Cas9 has opened up new and wide-ranging possibilities across biology, agriculture and medicine, including the treatment of thousands of intractable diseases. Doudna and Charpentier, director of the Max Planck Institute for Infection Biology, will share the 10 million Swedish krona (more than $1 million) prize. “This great honor recognizes the history of CRISPR and the collaborative story of harnessing it into a profoundly powerful engineering technology that gives new hope and possibility to our society,” said Doudna. “What started as a curiosity‐driven, fundamental discovery project has now become the breakthrough strategy used by countless researchers working to help improve the human condition. I encourage continued support of fundamental science as well as public discourse about the ethical uses and responsible regulation of CRISPR technology.” Video by Clare Major & Roxanne Makasdjian

SOURCE

http://news.berkeley.edu/ http://www.facebook.com/UCBerkeley http://twitter.com/UCBerkeley http://instagram.com/ucberkeleyofficial

 

Jennifer Doudna wins 2020 Nobel Prize in chemistry

By Robert Sanders, UC BerkeleyWednesday, October 7, 2020

“This great honor recognizes the history of CRISPR and the collaborative story of harnessing it into a profoundly powerful engineering technology that gives new hope and possibility to our society,” said Doudna. “What started as a curiosity‐driven, fundamental discovery project has now become the breakthrough strategy used by countless researchers working to help improve the human condition. I encourage continued support of fundamental science as well as public discourse about the ethical uses and responsible regulation of CRISPR technology.”

“The groundbreaking work of professor Jennifer Doudna has ushered in a revolutionary new era in genomics,” said UC President Michael V. Drake, M.D., in a statement this morning. “This Nobel Prize, which recognizes the discovery and real-world applications of CRISPR-Cas9, will continue to transform the scientific world, opening up new avenues for curing genetic diseases, improving crops and developing new biofuels. On behalf of the entire UC community, I join Chancellor Carol Christ in extending heartfelt congratulations to professor Doudna.”

While women have done research at UC Berkeley that, after they left the campus, won them a Nobel Prize, Doudna is the first woman on the UC Berkeley faculty to win the coveted award. She is the campus’s 25th Nobel laureate; the 24th winner, Reinhard Genzel, won the Nobel Prize in physics just yesterday.

Today’s honor also brings another first: Doudna and Charpentier are the first women to win a Nobel Prize in the sciences together, which sends the message, Doudna said, that “women rock.”

“Many women think that, no matter what they do, their work will never be recognized the way it would be if they were a man,” said Doudna, who was awakened from a sound sleep by a reporter at 2:53 a.m. today, learning for the first time that she’d won a Nobel. “And I think (this prize) refutes that. It makes a strong statement that women can do science, women can do chemistry, and that great science is recognized and honored.

“That means a lot to me personally, because I know that, when I was growing up, I couldn’t, in a million years, have ever imagined this moment.”

Doudna said she is “really, really proud to be representing Berkeley, … a public university that supports great science and great education, … a place that welcomes everyone, people from all over the world.” She added, “It’s a great feeling to have such incredible colleagues who are part of this.”

SOURCE

https://www.universityofcalifornia.edu/news/jennifer-doudna-wins-2020-nobel-prize-chemistry?utm_source=fiat-lux&utm_medium=internal-email&utm_campaign=article-general&utm_content=text

 

Jennifer Doudna in the PBS Movie CRISPR Our critically-acclaimed documentary HUMAN NATURE is now streaming on NETFLIX. #HumanNatureFilm. Find out more about the film on our website.

 

Other Articles on the Nobel Prize in this Open Access Journal Include:

2020 Nobel Prize for Physiology and Medicine for Hepatitis C Discovery goes to British scientist Michael Houghton and US researchers Harvey Alter and Charles Rice

CONTAGIOUS – About Viruses, Pandemics and Nobel Prizes at the Nobel Prize Museum, Stockholm, Sweden 

AACR Congratulates Dr. William G. Kaelin Jr., Sir Peter J. Ratcliffe, and Dr. Gregg L. Semenza on 2019 Nobel Prize in Physiology or Medicine

2018 Nobel Prize in Physiology or Medicine for contributions to Cancer Immunotherapy to James P. Allison, Ph.D., of the University of Texas, M.D. Anderson Cancer Center, Houston, Texas. Dr. Allison shares the prize with Tasuku Honjo, M.D., Ph.D., of Kyoto University Institute, Japan

2017 Nobel prize in chemistry given to Jacques Dubochet, Joachim Frank, and Richard Henderson  for developing cryo-electron microscopy

2016 Nobel Prize in Chemistry awarded for development of molecular machines, the world’s smallest mechanical devices, the winners: Jean-Pierre Sauvage, J. Fraser Stoddart and Bernard L. Feringa

Correspondence on Leadership in Genomics and other Gene Curations: Dr. Williams with Dr. Lev-Ari

Programming life: An interview with Jennifer Doudna by Michael Chui, a partner of the McKinsey Global Institute

Read Full Post »

2020 Nobel Prize for Physiology and Medicine for Hepatitis C Discovery goes to British scientist Michael Houghton and US researchers Harvey Alter and Charles Rice

Posted in Interviews with Scientific Leaders, Nobel Prize WInners on October 5, 2020| 1 Comment »

2020 Nobel Prize for Physiology and Medicine for Hepatitis C Discovery goes to British scientist Michael Houghton and US researchers Harvey Alter and Charles Rice

Reporter: Aviva Lev-Ari, PhD, RN

 

The Nobel Prize in Physiology or Medicine 2020

The Nobel Prize in Physiology or Medicine 2020 was awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus.”

 

Nobel Prize for Medicine goes to Hepatitis C discovery

By James Gallagher Health and science correspondent

The winners are British scientist Michael Houghton and US researchers Harvey Alter and Charles Rice.

The Nobel Prize committee said their discoveries ultimately “saved millions of lives”. The virus is a common cause of liver cancer and a major reason why people need a liver transplant.

In the 1960s, there was huge concern that people receiving donated blood were getting chronic hepatitis (liver inflammation) from an unknown, mysterious disease. The Nobel Prize committee said a blood transfusion at the time was like “Russian roulette”. Highly sensitive blood tests mean such cases have now been eliminated in many parts of the world, and effective anti-viral drugs have also been developed. “For the first time in history, the disease can now be cured, raising hopes of eradicating Hepatitis C virus from the world,” the prize committee said. However, the 70 million people are currently living with the virus, which still kills around 400,000 a year.

The mystery killer

The viruses Hepatitis A and Hepatitis B had been discovered by the mid-1960s.

But Prof Harvey Alter, while studying transfusion patients at the US National Institutes of Health in 1972, showed there was another, mystery, infection at work. Patients were still getting sick after receiving donated blood. He showed that giving blood from infected patients to chimpanzees led to them developing the disease.

The mysterious illness became known as “non-A, non-B” hepatitis in and the hunt was now on.

Prof Michael Houghton, while at the pharmaceutical firm Chiron, managed to isolated the genetic sequence of the virus in 1989. This showed it was a type of flavivirus and it was named Hepatitis C.

And Prof Charles Rice, while at Washington University in St. Louis, applied the finishing touches in 1997. He injected a genetically engineered Hepatitis C virus into the liver of chimpanzees and showed this could lead to hepatitis.

SOURCE

https://www.bbc.com/news/health-54418463

2014, 2015, 2016, 2017, 2019 Nobel Prize in Medicine went to:

• 2019 – Sir Peter Ratcliffe, William Kaelin and Gregg Semenza for discovered how cells sense and adapt to oxygen levels
• 2018 – James P Allison and Tasuku Honjo for discovering how to fight cancer using the body’s immune system
• 2017- Jeffrey Hall, Michael Rosbash and Michael Young for unravelling how bodies keep a circadian rhythm or body clock
• 2016 – Yoshinori Ohsumi for discovering how cells remain healthy by recycling waste
• 2015 – William C Campbell, Satoshi Ōmura and Youyou Tu for anti-parasite drug discoveries
• 2014 – John O’Keefe, May-Britt Moser and Edvard Moser for discovering the brain’s navigating system

 

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