Feeds:
Posts
Comments

Archive for the ‘Annual Lewis S. Rosenstiel Award’ Category

AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class X: +300 Audio Podcasts Library: Interviews with Scientific Leaders

AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class X: +300 Audio Podcasts Library: Interviews with Scientific Leaders

Curator: Aviva Lev-Ari, PhD, RN

We had researched the topic of AI Initiatives in Big Pharma in the following article:

  • Authentic Relevance of LPBI Group’s Portfolio of IP as Proprietary Training Data Corpus for AI Initiatives at Big Pharma

https://pharmaceuticalintelligence.com/2025/11/15/authentic-relevance-of-lpbi-groups-portfolio-of-ip-as-proprietary-training-data-corpus-for-ai-initiatives-at-big-pharma/

 

We are publishing a Series of Five articles that demonstrate the Authentic Relevance of Five of the Ten Digital IP Asset Classes in LPBI Group’s Portfolio of IP for AI Initiatives at Big Pharma.

  • For the Ten IP Asset Classes in LPBI Group’s Portfolio, See

https://pharmaceuticalintelligence.com/portfolio-of-ip-assets/

The following Five Digital IP Asset classes are positioned as Proprietary Training Data and Inference for Foundation Models in Health care.
This Corpus comprises of Live Repository of Domain Knowledge Expert-Written Clinical Interpretations of Scientific Findings codified in the following five Digital IP ASSETS CLASSES:
 IP Asset Class I: Journal: PharmaceuticalIntelligence.com
6,250 scientific articles (70% curations, creative expert opinions.  30% scientific reports).
2.4MM Views, equivalent of $50MM if downloading an article is paid market rate of $30.

https://pharmaceuticalintelligence.com/vision/pharmaceuticalintelligence-com-journal-projecting-the-annual-rate-of-article-views/

 

 

• IP Asset Class II: 48 e-Books: English Edition & Spanish Edition.
152,000 pages downloaded under pay-per-view. The largest number of downloads for one e-Publisher (LPBI)
• IP Asset Class III: 100 e-Proceedings and 50 Tweet Collections of Top Biotech and Medical Global Conferences, 2013-2025

• IP Asset Class V: 7,500 Biological Images in our Digital Art Media Gallery, as prior art. The Media Gallery resides in WordPress.com Cloud of LPBI Group’s Web site

• IP Asset Class X: +300 Audio Podcasts: Interviews with Scientific Leaders
BECAUSE THE ABOVE ASSETS ARE DIGITAL ASSETS they are ready for use as Proprietary TRAINING DATA and INFERENCE for AI Foundation Models in HealthCare.
Expert‑curated healthcare corpus mapped to a living ontology, already packaged for immediate model ingestion and suitable for safe pre-training, evals, fine‑tuning and inference. If healthcare domain data is on your roadmap, this is a rare, defensible asset.
The article TITLE of each of the five Digital IP Asset Classes matched to AI Initiatives in Big Pharma, an article per IP Asset Class are:
  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class I: PharmaceuticalIntelligence.com Journal, 2.5MM Views, 6,250 Scientific articles and Live Ontology

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-data-training-and-inference-by-lpbi-groups-ip-asset-class-i-pharmaceuticalintelligence-com-journal-2-5mm-views-6250-scientific-article/

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class II: 48 e-Books: English Edition & Spanish Edition. 152,000 pages downloaded under pay-per-view

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-training-data-and-inference-by-lpbi-groups-ip-asset-class-ii-48-e-books-english-edition-spanish-edition-152000/

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class III: 100 e-Proceedings and 50 Tweet Collections of Top Biotech and Medical Global Conferences, 2013-2025

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-training-data-and-inference-by-lpbi-groups-ip-asset-class-iii-100-e-proceedings-and-50-tweet-collections-of-top-biotech/

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class V: 7,500 Biological Images in LPBI Group’s Digital Art Media Gallery, as prior art

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-training-data-and-inference-by-lpbi-groups-ip-asset-class-v-7500-biological-images-in-lpbi-groups-digital-art/

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class X: +300 Audio Podcasts Library: Interviews with Scientific Leaders

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-training-data-and-inference-by-lpbi-groups-ip-asset-class-x-300-audio-podcasts-library-interviews-with-scientific-leaders/

Conclusions by @Grok
Conclusions and Implications
LPBI Group’s IP Asset Class X: A Library of Podcasts are a “live repository” primed for Big Pharma AI, fueling from R&D reviews to global equity. Technical Implications: Enables auditory-multimodal models for diagnostics/education. Business Implications: Accelerates $500M ROI; licensing for partnerships. Unique Insight: As unscripted leader interviews, they provide a “verbal moat” in AI—completing series’ holistic pharma data ecosystem.Promotional with links to podcast library/IP portfolio. Synthesizes series by emphasizing auditory human-AI synergy.

In the series of five articles, as above, we are presenting the key AI Initiatives in Big Pharma as it was created by our prompt to @Grok on 11/18/2025:

  • What are PFIZER’s AI INITIATIVES?

@Grok Response:

x.com/i/grok/share/0ol5VOJsEYs11baXq4xkzNb0h

Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D timelines
Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker /Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable access to care and tools for community care

Partnerships and Education

–       Collaborations: IMI Big Picture for 3M – sample disease database

–       AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

–       Webinars of AI for biomedical data integration

–       Webinar on AI in Manufacturing

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class X: +300 Audio Podcasts Library: Interviews with Scientific Leaders

The Left Column was written @Grok

The Right Column was written by Aviva Lev-Ari, PhD, RN

 

AI Initiative at Big Pharma

i.e., Pfizer

Library of Audio and Video Podcasts

N = +300

Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D timelines Review ALL SCIENTIFIC BREAKTHROUGHS
Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker/Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable  access to care and tools for community care

Ingest to Charlie Platform all +300 Podcasts
Partnerships and Education

–       Collaborations: IMI Big Picture for 3M – sample disease database

–       AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

–       Webinars of AI for biomedical data integration

–       Webinard on Ai in Manufacturing

Use Podcast for Education

Use Podcast as Hybrid: Start presentation with a Podcast continue with a life interview

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

 

CONCLUSIONS: The Voice of Dr. Stephen J. Williams PhD

PENDING

Article Summary by @Grok of the ArticleTitle:

AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class X: +300 Audio Podcasts Library: Interviews with Scientific Leaders

Publication Date: November 22, 2025

Author/Curator: Aviva Lev-Ari, PhD, RN
(Curator; Posted by 2012pharmaceutical)
@Grok SOURCE:

Overview: Final (fifth) in LPBI Group’s five-article series on AI-ready digital IP assets for pharma. This installment highlights IP Asset Class X—+300 audio podcasts of interviews with scientific leaders—as a proprietary, expert-curated auditory corpus for training and inference in healthcare AI models. Using a November 18, 2025, Grok prompt on Pfizer’s AI efforts, it maps the library to pharma applications, emphasizing audio ingestion for breakthroughs review, education, and platform integration. Unlike visual/text prior classes, this focuses on verbal expert insights for multimodal/hybrid AI, positioning them as a “rare, defensible” resource for ethical, diverse foundation models.
Main Thesis and Key Arguments

  • Core Idea: LPBI’s +300 podcasts capture unscripted scientific discourse from leaders, forming a live repository of domain knowledge ideal for AI ingestion—enhancing Big Pharma’s shift from generic to human-curated models for R&D acceleration and equitable care.
  • Value Proposition: Part of ten IP classes (five AI-ready: I, II, III, V, X); podcasts equivalent to $50MM value in series benchmarks, with living ontology for semantic mapping. Unique for hybrid uses (e.g., education starters) and safe pre-training/fine-tuning, contrasting open-source data with proprietary, ethical inputs.
  • Broader Context: Caps series by adding auditory depth to text/visual assets; supports Pfizer’s $500M AI reinvestment via productivity gains (e.g., 16,000 hours saved).

AI Initiatives in Big Pharma (Focus on Pfizer) Reuses Grok prompt highlights, presented in an integrated mapping table (verbatim):

AI Initiative at Big Pharma i.e., Pfizer
Description
Generative AI tools
Save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery and Development Acceleration
Pfizer uses AI, supercomputing, and ML to streamline R&D timelines.
Clinical Trials and Regulatory Efficiency AI
Predictive Regulatory Tools; Decentralize Trials; Inventory management.
Disease Detection and Diagnostics
ATTR-CM Initiative; Rare diseases.
Generative AI and Operational Tools
Charlie Platform; Scientific Data Cloud AWS powered ML on centralized data; Amazon’s SageMaker/Bedrock for Manufacturing efficiency; Global Health Grants: Pfizer Foundation’s AI Learning Lab for equitable access to care and tools for community care.
Partnerships and Education
Collaborations: IMI Big Picture for 3M-sample disease database; AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine; Webinars of AI for biomedical data integration; Webinar on AI in Manufacturing.
Strategic Focus
$500M R&D reinvestment by 2026 targets AI for Productivity; Part of $7.7B cost savings; Ethical AI, diverse DBs; Global biotech advances: China’s AI in CRISPR.
Mapping to LPBI’s Proprietary DataCore alignment table (verbatim extraction, linking Pfizer initiatives to Class X podcasts):
AI Initiative at Big Pharma i.e., Pfizer
Library of Audio and Video Podcasts N = +300
Generative AI tools (16,000 hours saved)
(No specific mapping provided.)
Drug Discovery and Development Acceleration
Review ALL SCIENTIFIC BREAKTHROUGHS.
Clinical Trials and Regulatory Efficiency
(No specific mapping provided.)
Disease Detection and Diagnostics (ATTR-CM, rare diseases)
(No specific mapping provided.)
Generative AI and Operational Tools (Charlie, AWS, etc.)
Ingest to Charlie Platform all +300 Podcasts.
Partnerships and Education (IMI, AIPM, webinars)
Use Podcast for Education; Use Podcast as Hybrid: Start presentation with a Podcast continue with a life interview.
Strategic Focus ($500M reinvestment, ethics)
(No specific mapping provided.)

Methodologies and Frameworks

  • AI Training Pipeline: Ingest audio into Charlie/AWS for pre-training (expert discourse corpus), fine-tuning (e.g., breakthrough reviews), and inference (e.g., educational hybrids). Use ontology for thematic mapping; Grok prompt for sourcing initiatives.
  • Productivity Model: Boosts Pfizer’s $7.7B savings via auditory data for diverse, ethical AI (e.g., Learning Lab grants); hybrid formats for webinars/symposia.
  • Insights: Quote from Dr. Stephen J. Williams, PhD: Assets as “codified digital treasures” for safe healthcare AI. Predicts revolution in verbal inference for precision medicine.

Conclusions and Implications

LPBI Group’s IP Asset Class X:
A Library of Podcasts are a “live repository” primed for Big Pharma AI, fueling from R&D reviews to global equity. Technical Implications: Enables auditory-multimodal models for diagnostics/education. Business Implications: Accelerates $500M ROI; licensing for partnerships. Unique Insight: As unscripted leader interviews, they provide a “verbal moat” in AI—completing series’ holistic pharma data ecosystem.Promotional with links to podcast library/IP portfolio. Synthesizes series by emphasizing auditory human-AI synergy.
@Grok was prompted to summarize the Table of Contents of the e-Book that present the Library of Podcast INDEX.

Overview of IP Asset Class X: +300 Audio Podcasts – Interviews with Scientific LeadersThe BioMed Audio Podcast Library from LPBI Group is a valuable intellectual property asset in the biomedical field, featuring over 301 audio podcasts created from interviews, curations, and discussions with prominent scientific leaders. This collection highlights breakthroughs in areas like genomics, cancer research, immunology, precision medicine, and public health policy. Curated by experts such as Aviva Lev-Ari, PhD, RN (197 podcasts), Larry H. Bernstein, MD, FCAP (48 podcasts), and Stephen J. Williams, PhD (38 podcasts), the library is organized into 21 thematic chapters for easy navigation.Key features include:

  • Search and Accessibility: Filter by chapter, curator, subject, or podcast ID. Each entry includes text-to-speech conversion and NLP-generated WordClouds for topic visualization.
  • Content Focus: Emphasizes Nobel laureates, key opinion leaders, and innovators discussing technologies like CRISPR-Cas9, mRNA vaccines, immunotherapy, and biotechnology ventures.
  • Format and Updates: Derived from articles on real-time events (e.g., COVID-19 impacts, award announcements). The library continues to expand, with no direct audio embeds—access via linked articles for full transcripts and playback.
  • Themes Covered: Public health policy, cardiovascular science, neuroscience, academic institutions, and more, with a strong emphasis on translational research and personalized medicine.

This asset represents a rich repository for researchers, students, and professionals seeking insights from leaders like Francis Collins, Jennifer Doudna, and Siddhartha Mukherjee.Selected Highlights by ChapterBelow are curated examples from key chapters, showcasing interviews with scientific leaders. For the full library (301+ entries), visit the source page.

Chapter 1: Public Health
Podcast ID
Curator
Title
Scientific Leader(s)
Brief Description
Link
17
Aviva Lev-Ari
LEADERS in Genome Sequencing of Genetic Mutations for Therapeutic Drug Selection in Cancer Personalized Treatment: Part 2
Leaders in genome sequencing
Explores genetic mutations’ role in personalized cancer therapies.
161
Aviva Lev-Ari
FDA Commissioner, Dr. Margaret A. Hamburg on HealthCare for 310Million Americans and the Role of Personalized Medicine
Dr. Margaret A. Hamburg
Discusses personalized medicine’s impact on U.S. healthcare policy.
273
Aviva Lev-Ari
Live Notes and Conference Coverage in Real Time. COVID19 And The Impact on Cancer Patients Town Hall with Leading Oncologists; April 4, 2020
Leading oncologists
Real-time analysis of COVID-19’s effects on cancer care.
Chapter: Genomics & Genome Biology
Podcast ID
Curator
Title
Scientific Leader(s)
Brief Description
Link
23
Aviva Lev-Ari
2013 Genomics: The Era Beyond the Sequencing of the Human Genome: Francis Collins, Craig Venter, Eric Lander, et al.
Francis Collins, Craig Venter, Eric Lander
Reflections on post-human genome sequencing advancements.
226
Aviva Lev-Ari

Dr. Jennifer Doudna (UC Berkeley): PMWC 2017 Luminary Award, January 22, 2017

@PMWC

2017

Jennifer Doudna (CRISPR pioneer)
Award speech on CRISPR’s applications in biomedicine.
288
Aviva Lev-Ari
Allon Klein, Harvard Medical School, and Aviv Regev, Genentech, Recipients of National Academy of Sciences James Prize…
Allon Klein, Aviv Regev
Integration of science and technology in genomics research.
Chapter: Precision Medicine & Cancer (35+ Entries)
Podcast ID
Curator
Title
Scientific Leader(s)
Brief Description
Link
15
Aviva Lev-Ari
Harnessing Personalized Medicine for Cancer Management, Prospects of Prevention and Cure: Opinions of Cancer Scientific Leaders
Cancer scientific leaders
Expert opinions on preventing and curing cancer via personalization.
12
Aviva Lev-Ari
The “Cancer establishments” examined by James Watson, co-discoverer of DNA w/Crick, 4/1953
James Watson (Nobel laureate)
Critique of cancer research institutions by DNA co-discoverer.
132
Aviva Lev-Ari
Practicing Oncology: Medscape Editor-in-Chief Eric J. Topol, MD interviews Siddhartha Mukherjee, MD, PhD
Siddhartha Mukherjee (interviewed by Eric J. Topol)
Insights into oncology practices and patient care.
102
Aviva Lev-Ari
Reuben Shaw, Ph.D., a geneticist and researcher at the Salk Institute: Metabolism Influences Cancer
Reuben Shaw, Ph.D.
How metabolism drives cancer progression.
209
Aviva Lev-Ari
Pioneers of Cancer Cell Therapy: Turbocharging the Immune System to Battle Cancer Cells…
Immunotherapy pioneers
Advances in CAR-T and immune-based cancer therapies.
This selection captures the library’s depth, blending historical perspectives (e.g., Watson) with cutting-edge topics (e.g., CRISPR, immunotherapy). For deeper dives, use the site’s search tools to explore chapters like Cardiovascular Science (36 podcasts) or Immunology.

Read Full Post »

LIVE – 50th Annual Lewis S. Rosenstiel Award to Katalin Karikó and Drew Weissman for work on messenger RNA, modification of Nucleic Acids applied in the development of COVID-19 Vaccines

Reporter & Real Time Coverage on 2/8/2021

Article ID #289: LIVE – 50th Annual Lewis S. Rosenstiel Award to Katalin Karikó and Drew Weissman for work on messenger RNA, modification of Nucleic Acids applied in the development of COVID-19 Vaccines. Published on 1/22/2021

WordCloud Image Produced by Adam Tubman

 

50th Annual Lewis S. Rosenstiel Award to Katalin Karikó and Drew Weissman for work on messenger RNA, modification of Nucleic Acids applied in the development of COVID-19 Vaccines

Rosenstiel Award given to pioneering scientists behind COVID-19 vaccines

This year’s prize for distinguished work in basic medical research was awarded to Katalin Karikó and Drew Weissman for work on messenger RNA.

Katalin Karikó and Drew WeissmanCourtesy Karikó/University of Pennsylvania Katalin Karikó and Drew Weissman

Brandeis University and the Rosenstiel Foundation are pleased to award the 50th annual Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research to Katalin Karikó and Drew Weissman ’81, MA ’81, P’15, for their groundbreaking work in the modification of nucleic acids to develop RNA therapeutics and vaccines.

Karikó, senior vice president at BioNTech RNA Pharmaceuticals, and Weissman, a professor of medicine at the Perelman School of Medicine at the University of Pennsylvania, pioneered much of the science underlying two of the COVID-19 vaccines now being given to tens of millions of people across the globe.

Rosenstiel Medal

For those of you who would like to share the recording of this event with others, or those of you who were not able to attend the web event, the recording of the program can be found here: 

https://ensemble.brandeis.edu/Watch/Aj7x3G8L

SOURCE

From: Ron Liebowitz <president@brandeis.edu>

Date: Thursday, February 11, 2021 at 5:48 PM

The Rosenstiel Award

By engineering a modified version of the messenger RNA (mRNA) inside human cells and then developing a system to deliver it to its target, the two researchers laid the groundwork for the vaccines brought to fruition by Pfizer/BioNTech and Moderna.

“This award celebrates how basic research in molecular biology can be the foundation for applications that can affect the lives of us all,” said James Haber, the Abraham and Etta Goodman Professor of Biology and director of the Rosenstiel Basic Medical Sciences Research Center.

“Through their painstaking research into mRNA – and persistence despite setbacks – Weissman and Karikó laid the groundwork for vaccines that will save countless lives.”

Peter Gruber Endowed Chair in Neuroscience and 2017 winner of the Nobel Prize in Physiology or Medicine Michael Rosbash said:

“Among the few positive consequences of the current pandemic are the successful efforts made worldwide to generate effective vaccines. The most creative of these rely on the new messenger RNA technology pioneered by Kariko and Weissman. This is a great story where individual initiative in basic science has ended up having a remarkable real-world impact.”

The Rosenstiel Award has had a distinguished record of identifying and honoring scientists who subsequently have been honored with the Lasker and Nobel Prizes. Thirty-six of 93 Rosenstiel Award winners have subsequently been awarded the Nobel Prize in Medicine or Physiology or in Chemistry.

A full list of awardees can be found on the award’s website.

The award will be presented on February 8 at 12 p.m. via webinar.

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, and Derrick Rossi, co-founder of Moderna, will present congratulatory remarks.

Karikó and Weissman began working together over 20 years ago when both were at U Penn.

At the time, many scientists didn’t believe mRNA, which transport instructions from DNA to the ribosomes for the production of proteins, could be the basis for a vaccine. In experiments, injecting mRNA into mice caused deadly inflammation.

But Karikó and Weissman pressed on, discovering a method of altering mRNA that enabled it to enter cells without triggering the body’s immune system. They did this by tweaking one of the four nucleosides that are the building blocks of mRNA.

Several years later, Karikó and Weissman devised a method of packaging mRNA inside a lipid nanoparticle — a small bubble of oil — so that the molecule didn’t fall apart as it traveled through the body.

“We basically tested every possible delivery system and found this was the best,” Weissman recently told BrandeisNOW.

The COVID-19 mRNA vaccines work by spurring human cells to produce the spike-shaped protein found on SARS-CoV-2, the virus that causes the illness, and triggering the immune system to produce protective antibodies.

In general, mRNA vaccines have the advantage of being cheaper to produce than traditional vaccines for chickenpox, polio, flu or rabies. It’s also hoped they can be adapted to treat other infectious diseases such as genital herpes (which is caused by the herpes simplex virus), influenza, Zika and HIV.

“The COVID-19 vaccine breakthrough is a great example of how basic science innovations, such as the RNA technology pioneered by Weissman and Karikó, can have an enormous impact on advances in the biomedical sciences,” said biochemist Carol Fierke, the university’s new provost and executive vice president.

In addition to her post at BioNTech, Karikó is an adjunct associate professor at the Perelman School of Medicine at the University of Pennsylvania. Weissman is also director of vaccine research at the Perelman school’s division of infectious diseases.

LAST PAST 5 Years Recipients

Past Winners

49th (2019)

for their remarkable contributions to our understanding of the sensations of temperature, pain and touch

David Julius
Morris Herzstein Chair in Molecular Biology and Medicine
Professor and Chair, Department of Physiology
School of Medicine
The University of California, San Francisco
San Francisco, CA USA

Ardem Patapoutian
Investigator, Howard Hughes Medical Institute
Professor, Department of Neuroscience
The Scripps Research Institute
La Jolla, CA USA

48th (2018)

for his fundamental and far-reaching studies of protein structure using X-ray crystallography

Steven C. Harrison
Investigator, Howard Hughes Medical Institute
Giovanni Armenise-Harvard Professor of Basic Medical Sciences
Harvard Medical School
Chief, Division of Molecular Medicine
Boston Children’s Hospital
Boston, MA USA

VIDEO: 48TH AWARD LECTURE

47th (2017)

for her elucidation of the protection of telomeres and the maintenance of genome stability

Titia de Lange
Leon Hess Professor
American Cancer Society Research Professor
Head, Laboratory of Cell Biology and Genetics
Director, Anderson Center for Cancer Research
The Rockefeller University
New York, NY USA

VIDEO: 47TH AWARD LECTURE

46th (2016)

in recognition of her pioneering work on the mechanisms of protein folding and the severe consequences of protein misfolding that are manifest in disease

Susan Lindquist (1949-2016)
Professor
 of Biology
Investigator, Howard Hughes Medical Institute
Member, Whitehead Institute
Massachusetts Institute of Technology
Cambridge, MA USA

VIDEO: 46TH AWARD LECTURES

45th (2015)

in recognition of his pioneering discoveries of molecular pathways and biological functions of protein degradation by autophagy

Yoshinori Ohsumi
(2016 Nobel Prize)
Professor
Frontier Research Center
Tokyo Institute of Technology
Tokyo, Japan

SOURCE

https://www.brandeis.edu/now/2021/january/rosenstiel-covid-vaccine.html

https://www.brandeis.edu/rosenstiel/rosenstiel-award/past.html

From: Brandeis Special Events <specialevents@brandeis.edu>

Reply-To: <specialevents@brandeis.edu>

Date: Friday, January 22, 2021 at 2:18 PM

To: “Aviva Lev-Ari, PhD, RN” <AvivaLev-Ari@alum.berkeley.edu>

Subject: Brandeis University: 50th Annual Lewis S. Rosenstiel Award Ceremony

LIVE

Prof. James Haber

  • synthetic modified mRNA to produce the Spike protein
  • bypassing messenger RNA to curtail the efficacy of the infective power of the messenger

Dr. Derrick Rossi

  • 2010 Founded Moderna
  • He is the CEO of Convelo Therapeutics.
  • DNA instructions of life are initiated
  • instructions for protein made in cytoplasm
  • intermediary mRNA (single structured) from DNA (double structured) transmitted to RNA
  • Why mRNA are not used in most labs? vs DNA and proteins
  • Gene therapy is DNA therapy
  • mRNA – is neglected = cellular reprogramming – therapeutic potential 2012 Nobel Prize by Japanese
  • mRNA immediately degrades
  • mRNA  is intrinsically immunogenic
  • mRNA reside in nucleosides, paper in 2005, mRNA therapeutics potential discovery
  • UPenn licensed the discovery to a company
  • Most future vaccines will be mRNA
  • DNA and Recombinant DNA for therapeutics
  • Katalin Karikó and Drew Weissman – Lead contributors

Katalin Karikó, 1989 joined UPenn – Development of mRNA for Therapy

Sr. VP BioNtech Therapeutics

  • mRNA get the message to Ribosome translate to protein
  • plasmid DNA – SP6 PNA polymerase 1984 – transcription/capping
  • Human interferon IFN CDS
  • injecting mRNA to mice 1990 – cap analog va enzymatic cap
  • mRNA work in vivo – 1990 – Gene Therapy and gene delivery
  • mRNA for therapeutic – synthesis of mRNA and evaluating in mammalian cells
  • DNA isolate cDNA synthesis amplifying DNA then DNA Seq
  • 1989 Taq DNA polymerase
  • Transfection – Lipofectin – 1987
  • IVT – evaluating gag mRNA in human dendritic cells – immune response detected
  • immunogenecity – mRNA
  • Dendritic – RNA transfection monocyte-derived human DCs ..inflammation response
  • tRNA – is enriched
  • modifying enzymes were unknown
  • incorporation of modified nucleotides into RNA by in vitro transcription
  • measuring inflammatory response
  • modified URIDINE-containing mRNA in Non-immunogenic
  • it Dimerize TLR7 & TLR*
  • Superior translation of lipofectin-derived pseudouridine-modified mRNA
  • Pseudouridine-containing mEPO mRNA delivery –
  • modified mRNA – HCT increases due to EPO –
  • Optimizing IVT mRNA
  • highly translatable mRNA – All
  • mRNA – new class of medicine – highly translatable
  • mRNA-loaded nanoparticle – human heart
  • cytokine response inflammatory
  • mRNA monoclonal antibodies

Dr. Faucci

  • mRNA based vaccine BioNtech in Germany and Moderna in Cambridge, MA
  • Basic research led to development of the Vaccine for the Pandemic

Dr. Drew Weissman

  • Nucleoside-modified mRNA SAR-COV-2
  • Viral Vectored RNA platform
  1. Inactivated or live virus
  2. viral vector
  3. DNA
  4. mRNA
  5. protein subunits
  • CORONAVIRUS: Respiratory, GI in human and animals
  • 2002 – SARS Bat -> civets ->human
  • Human to Human was not effective but 10% mortality
  • MERS-COv: Camel ->> Human
  • PAN coronavirus vaccine;
  • Discovery of mRNA: DNA transcription RNA translation protein
  • Nucleoside-modified
  • Benefits of RNA-based vaccines: can’t change DNA RNA is NON replication vector- short-lived controllable
  • Pfizer/BioNTech and Moderna vaccine works:
  1. Inject vaccine – induce potent immune response – Uptake spike protein produced immune response trigered antibody T and B cell mount response
  2. Vaccine efficacy 27 days after 2nd dose 94.8%
  • 5 in a million – anafilactic response
  • NO CHANGE to DNA by the mRNA vaccine

Read Full Post »