Irina Robu, PhD

Irina Robu, PhD – 3D BioPrinting, Tissue Engineering, Biomaterials, Nanotechnology & Drug Delivery

INACTIVE 12/31/2021

UPDATED on 11/9/2020

JOINING Dr. Williams & Aviva on Virtual Conference Coverage in Real Time, following Training with Aviva – ASAP
Continue POSTING ONCE A WEEK
Work with Aviva on New Slides from Graphics in Documentation to 2.0 LPBI SLIDE DECK LIBRARY
Conduct Competitive Assessment for Blockchain in Healthcare

Roles @ PharmaceuticalIntelligence.com

(1) TNS #1: https://www.wolfram.com/featureset/machine-learning/

1.1 LPBI LEAD on Comparison of NLP results obtained for Microsoft AZURE and EXPERIMENT with Text Analysis The Wolfram Language

1.2 LPBI LEAD on Application on the ingress TEXT from: Cancer Volume 1 &2 and Genomics Volume 1&2

1.3 LPBI LEAD on Phase 3: Scaling up NLP, ML, AI to LPBI Group’s FOUR Corpuses Using LPBI’s Vendor of Choice:

The Wolfram Solution for Biological Sciences
The Wolfram Data Drop is an open service that makes it easy to accumulate data of any kind, from anywhere—setting it up for immediate computation, visualization, analysis, querying, or other operations

(2) Commissions by the Editor-in-Chief – One Curation per WEEK

(3) TNS #5: Joint venture with Dr. Nir for Drug Discovery

irina.robu@gmail.com 

(m) 734-365-9015

BIO

Growing up, math and science have always been the subjects that I have excelled at. I found that I enjoy the simplistic facts and solutions of math and science. I always categorized myself as a logical thinker, so solutions often having an indisputable answer involving number or coming to conclusions based on facts and data are the most comprehensive reasoning for me. When I set my mind to solving a problem, I am determined to complete that task. With curiosity comes determination, which is a quality I apply to every aspect of my life. I initially completed my Bachelor of Science in Chemistry from University of Windsor with the intention of pursuing a medical degree, but realized that I enjoy learing how a system/machine works more. This lead me to pursue a Bachelor and Masters in Chemical engineering at Wayne State University in Detroit Michigan. It was there that I was exposed to the area of biomedical engineering , which is the subject that has always stimulated my curiosity.

It was there at Wayne State that I decided to pursue a PhD in Chemical engineering with area of specilization in tissue enginering and biomaterials. During my PhD, I I worked on assessing the growth, proliferation, adhesion, and spreading of SMCs and ECs on covalently immobilized GAG-chitosan material in-vitro, created and evaluated seeding efficiency of GAG-chitosan vascular graft and designed and evaluate a pulsatile bioreactor system for long-term 3D culture of large diameter tissue engineered constructs with efficient cell seeding, cell distribution and viability. I was able to improve cell seeding using collagen gel for vascular grafts and enhance their viability and survival in vitro as well as show that carboxymethylated dextran sulfate-chitosan/collagen material is a beneficial material for growing both endothelial and smooth muscle cells.

In the doctoral research phase of my studies I saw the high research potential for finding a treatment for cardiovascular disease, currently different approaches have been evaluated such as surgical procedures, organ transplantation, implantation of mechanical and synthetic devices and the administration of metabolic products. After completing my PhD, I pursued a post doctoral research position at IUPUI, Indianapolis where I looked to address the deficiencies of the current therapies for by taking a tissue engineering approach to regenerate bone for transplantation. In this approach, bone marrow mesenchymal stem cells harvested from animal model were used to generate transplantable tissue structures in culture. Parallel to this project I evaluated bioglass scaffolds seeded with a mixture of bone marrow derived mesenchymal stem cells and collagen in static, in perfusion system and in vivo conditions.

After my post doctoral studies, I had a chance to work a patent researcher at London IP in Michigan where I preformed qualitative analysis of patents and patent portfolios as well as delivered competitive intelligence to identify potential research.

CURRICULUM VITAE

Scientist with extensive training in biomaterials and tissue engineering and with ability to independently lead scientific research and collaborate on a team to achieve scientific goals; develop methods and complete protocol design; eand provide statistical analysis and reporting of data in both written and oral reports.

EDUCATION

Ph.D. in Chemical Engineering (Tissue Engineering Research)
Wayne State University, Detroit,MI

M.Sc. in Chemical Engineering (Laser Optics Research)
Wayne State University, Detroit,MI

B.Sc in Chemical Engineering
Wayne State University, Detroit,MI

B.Sc. in Chemistry
University of Windsor, Windsor, Ontario, CA

PROFESSIONAL EXPERIENCE

Author/Writer for Leaders in Pharmaceutical Business Intelligence (Home-Based)

Several years of experience writing and editing curations, articles and regulatory documents on Biomaterials, Tissue Engineering, Stem Cells, Nanotechnology for Drug Deliver, Cell therapy and Technology Transfer.

Patent Researcher, Landon IP, Southfield, Michigan

Analyzed biomedical / chemical and biomedical device related databases (NCBI, PUB Med), IEEE journals, IEEE research papers, dissertations, thesis and other technical documentation for relevant prior art.

Postdoctoral Researcher, Indiana University-Purdue University, Indianapolis, IN

Conducted independent research to examine the osteogenic differentiation potential of mesenchymal stem cell and endometrial stem cells to test its feasibility for bone tissue engineering applications using analysis such as flow cytometry, RT-PCR, histological analysis, immunofluorescence, SEM, cell-based assays for proliferation and enzyme-based assays.Conducted implant studies to check the effects of 3D cylindrical SLS scaffolds on bone formation in rats.

Graduate Research Assistant, Chemical Engineering, Wayne State University, Detroit, MI

Developed an improved isolation and expansion protocols of ovine/bovine bone marrow-derived mesenchymal stem cells, blood vessels primary cells for cardiovascular tissue engineering applications.Designed and validated large-size custom bioreactor systems with controlled dynamic parameters to improve the cell functionality, seeding efficiency, and tissue functionality.

Research Assistant, Chemical Engineering Department, Wayne State University, Detroit, MI Researched large density gradient experiments with compressible supercritical CO2 and calibrated single ray path inhomogeneous supercritical CO2.

Research Engineer, Detroit Edison -Warren Service Center, Detroit MI

Identified problems, proposed solutions, and designed new methods of data acquisition, analysis and interpretation.

PUBLICATIONS

Irina Robu and David Orchard Webb, Manufacturability of Regenerative Medicine Products for Commercial Scale, Reference Module in Biomedical Sciences, Elsevier, October 2018.

Larry H. Bernstein, Aviva Lev-Ari, Irina Robu al. The Immune System, Stress Signaling, Infectious Diseases and Therapeutic Implications: VOLUME 2: Infectious Diseases and Therapeutics, Amazon Digital Services LLC. Kindle Edition. September 4, 2017.

Robu I.S., Walters III Henry L., Matthew Howard W.T. Morphological and growth responses of vascular smooth muscle and endothelial cells cultured on immobilized heparin and dextran sulfate surfaces. J Biomed Mater Res Part A 2017:105A:1725–1735.

Liu Wai Ching, Robu Irina, Patel Rikin, Leu Ming, Velez, Mariano, Chu, Tien-Min, The effects of 3D bioactive glass scaffolds and BMP-2 on bone formation in rat femoral critical size defects and adjacent bones, Biomedical Materials, Vol.9, Nr. 4, 2014 (* 50% contribution)

Robu I.S., Walters H.L., Matthew H.W.T. Morphological and Growth Responses of Vascular Smooth Muscle Cells Cultured on Immobilized Heparin and Dextran Sulfate Surfaces; Transactions of the 32nd Annual Meeting of the Society for Biomaterials 2007, 30, p646.

Robu I.S. and Erhard Rothe, Probes of supercritical CO2 by deflection of multiple beamlets, Journal of Flow Visualization & Image Processing, Vol. 12, pp. 1–11, 2005.

Robu I.S., Walters H.L., Matthew H.W.T., Morphological and Growth Responses of Vascular Smooth Muscle Cells and Aortic Endothelial Cells Cultured on Immobilized Heparin and Dextran Sulfate Surfaces, TERMIS North America 2007 Conference and Exposition, Toronto, Canada, poster #1495.

Robu I.S., Rothe Erhard W., Probes of Supercritical CΟ2 by Deflection of Multiple Beamlets; American Chemical Engineering Society Annual Meeting 2006, oral presentation.