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Outstanding Questions in Trends in Pharmacological Sciences – Serendipity in Cancer Drug Discovery: Rational or Coincidence?

 Reporter: Aviva Lev-Ari, PhD, RN

Volume 37, Issue 6, p435–450, June 2016

 

  • Why drug discovery should not rely on specific targets?
  • Are single targets not druggable?
  • What is the reason for the failure of drugs based on targeted therapy in clinical trials at advanced stages
  • Why are existing drugs, which are multitargeted, not considered for reinvestigation in other diseases?

SOURCE

Serendipity in Cancer Drug Discovery: Rational or Coincidence?

Sahdeo Prasad, Subash C. Gupta, Bharat B. Aggarwal3,correspondence
3Current address: Bharat B Aggarwal Founding Director, Anti-inflammation Research Institute, San Diego, CA, USA.

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