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Archive for the ‘LPBI Group, e-Scientific Media, DFP, R&D-M3DP, R&D-Drug Discovery, US Patents: SOPs and Team Management’ Category


BioMed e-Series: 16 Volumes – electronic Table of Contents (eTOCs) of each Volume

Curator: Aviva Lev-Ari, PhD, RN

CLICK on the RED Link to review eTOCs of each Volume

 

Series A: e-Books on Cardiovascular Diseases

Series Content Consultant: Justin D Pearlman, MD, PhD, FACC

Volume 1,2,3,4

Volume 1

Perspectives on Nitric Oxide in Disease Mechanisms – electronic Table of Contents http://www.amazon.com/dp/B00DINFFYC

https://www.linkedin.com/pulse/perspectives-nitric-oxide-disease-mechanisms-table-aviva/

 

Volume 2

Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation – electronic Table of Contents http://www.amazon.com/dp/B018Q5MCN8

https://www.linkedin.com/pulse/cardiovascular-original-research-cases-methodology-aviva/

 

Volume 3

Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics – electronic Table of Contents http://www.amazon.com/dp/B018PNHJ84

https://www.linkedin.com/pulse/etiologies-cardiovascular-diseases-epigenetics-lev-ari-phd-rn/

 

Volume 4

Regenerative and Translational Medicine: The Therapeutics Promise for Cardiovascular Diseases – eTOCs http://www.amazon.com/dp/B019UM909A

https://www.linkedin.com/pulse/regenerative-translational-medicine-therapeutics-lev-ari-phd-rn/

 

Volumes 5 and 6 – will be published in 2018

 

Series B: Frontiers in Genomics Research

Series Content Consultant: Prof. Marcus Feldman, Stanford University

Volume 1

Genomics Orientations for Personalized Medicine – electronic Table of Contents http://www.amazon.com/dp/B018DHBUO6 | LinkedIn

https://www.linkedin.com/pulse/genomics-orientations-personalized-medicine-table-lev-ari-phd-rn/?published=t

 

Volume 2 – will be published in 2018

 

Series C: e-Books on Cancer & Oncology

Series Content Consultant: Larry H Bernstein, MD, FCAP

 

Volume 1 – HOW This BOOK HELPS in Education of the Medicine as a Profession

Cancer Biology and Genomics for Disease Diagnosis – Electronic Table of Contents http://www.amazon.com/dp/B013RVYR2K | LinkedIn

https://www.linkedin.com/pulse/cancer-biology-genomics-disease-diagnosis-table-lev-ari-phd-rn/

 

Volume 2 – HOW This BOOK HELPS in Education of the Medicine as a Profession

Cancer Therapies: Metabolic, Genomics, Interventional, Immunotherapy and Nanotechnology in Therapy Delivery http://www.amazon.com/dp/B071VQ6YYK | LinkedIn

https://www.linkedin.com/pulse/cancer-therapies-metabolic-genomics-interventional-lev-ari-phd-rn/?published=t

 

Series D: e-Books on BioMedicine – Metabolomics, Immunology, Infectious Diseases

Series Content Consultant: Larry H Bernstein, MD, FCAP

 

Volume 1

Metabolic Genomics & Pharmaceutics electronic Table of Contents http://www.amazon.com/dp/B012BB0ZF0 | LinkedIn

https://www.linkedin.com/pulse/metabolic-genomics-pharmaceutics-electronic-table-lev-ari-phd-rn/

 

Volume 2

Infectious Diseases and Therapeutics e-Table of Contents, Volume 2 https://www.amazon.com/dp/B075CXHY1B | LinkedIn

https://www.linkedin.com/pulse/infectious-diseases-therapeutics-e-table-contents-2-lev-ari-phd-rn/

Volume 3

The Immune System and Therapeutics e-Table of Contents https://www.amazon.com/dp/B075CXHY1B | LinkedIn

https://www.linkedin.com/pulse/immune-system-therapeutics-e-table-contents-aviva-lev-ari-phd-rn/?published=t

Series E: Patient-Centered Medicine

Series Content Consultant: Larry H Bernstein, MD, FCAP

 

Volume 1

The VOICES of Patients, Hospitals CEOs, Health Care Providers, Caregivers and Families – e-Table of Contents https://www.amazon.com/dp/B076HGB6MZ | LinkedIn

https://www.linkedin.com/pulse/voices-patients-hospitals-ceos-health-care-providers-aviva/

 

Volume 2

Medical Scientific Discoveries for the 21st Century & Interviews with Scientific Leaders, e-Table of Contents https://www.amazon.com/dp/B078313281 | LinkedIn

https://www.linkedin.com/pulse/medical-scientific-discoveries-21st-century-leaders-lev-ari-phd-rn/

 

Volume 3

Milestones in Physiology – Discoveries in Medicine, Genomics and Therapeutics Patient-centric Perspective, eTOCs http://www.amazon.com/dp/B019VH97LU | LinkedIn

https://www.linkedin.com/pulse/milestones-physiology-discoveries-medicine-genomics-aviva/

 

Volume 4

Medical 3D BioPrinting – The Revolution in Medicine -Technologies for Patient-centered Medicine: From R&D in Biologics to New Medical Devices, eTOCs | LinkedIn

https://www.linkedin.com/pulse/medical-3d-bioprinting-revolution-medicine-from-rd-lev-ari-phd-rn/?published=t

 

BioMed e-Series

https://pharmaceuticalintelligence.com/biomed-e-books/

BioMed e-Series

WE ARE ON AMAZON.COM

https://www.amazon.com/s/ref=nb_sb_noss?url=search-alias%3Ddigital-text&field-keywords=Aviva+Lev-Ari&rh=n%3A133140011%2Ck%3AAviva+Lev-Ari

https://www.amazon.com/s/ref=dp_byline_sr_ebooks_9?ie=UTF8&text=Aviva+Lev-Ari&search-alias=digital-text&field-author=Aviva+Lev-Ari&sort=relevancerank

http://www.amazon.com/dp/B00DINFFYC

http://www.amazon.com/dp/B018Q5MCN8

http://www.amazon.com/dp/B018PNHJ84

http://www.amazon.com/dp/B018DHBUO6

http://www.amazon.com/dp/B013RVYR2K

http://www.amazon.com/dp/B012BB0ZF0

http://www.amazon.com/dp/B019UM909A

http://www.amazon.com/dp/B019VH97LU

http://www.amazon.com/dp/B071VQ6YYK

https://www.amazon.com/dp/B075CXHY1B

https://www.amazon.com/dp/B076HGB6MZ

https://www.amazon.com/dp/B078313281

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NEW Book #InfectiousDiseases #Immunology #StressSignaling #Therapeutics check https://www.amazon.com/dp/B075CXHY1B

Editor-in-Chief: Aviva Lev-Ari, PhD, RN

 

 

Includes FDA Approved Drugs for Infections and Infectious Diseases: Bacterial Infection, Viral Infection, Fungal Infection, Allergy-related Infections and Other, 1995 – 2016

VOLUME 2: covers the frontier of research on Infectious Diseases and the Human Immune System. The Immune Response, Disease Specific Immune Response, Immunodiagnostics and Immunotherapy, Immunotherapy and Autoimmunity,
Bacterial Infections, Bacteria Types, Antibactirial Therapeutics, FDA Approved Drugs for Infections and Infectious Diseases: Bacterial Infection, 1995 – 2016. Viral Infection: Virus Types, Antiviral Therapeutics, and FDA Approved Drugs for Infections and Infectious Diseases: Viral Infection, Fungal Infections, Allergy-related Infections, Other Infections,1995 – 2016,

VOLUME 3: covers the state of Science on the Historical Perspective of Immunology, Development of the Immune System, Signaling and Immunology, Cellular Immunity, Immunology and Inflammatory Response. Antibody-based Immunity, Vaccines and Microbiome, Immuno-Pharmaceutics, Cancer Immunotherapy, Immunomodulation and Neuro-Immunology.

Volume 2: Summary
The material that has been covered is a considerable material on the basic types of infections – bacterial, viral, and fungal, and diseases related to immune mechanisms. There has been a substantial coverage of the drugs and the manufacturers. This material brings to the discussion an international problem of drug resistance that applies much to bacteria, and a considerable amount of material on advances in drug development that takes into consideration protein structure and protein-protein interactions. The coverage of virus diseases brings to the forefront vaccines. However, in such cases as the influenza virus, a rapid genetic change of the virus makes the use of vaccines an issue for continuing revision.

Volume 3: Summary
The second volume is only concerned with the pathobiology of the inflammatory response, including sepsis, and it does not leave out hematopoiesis, and it lays out the difference between the B-clles and the T-cells that are related to the Toll receptor. Here we have looked closely at two immune disorders, Inflammatory Bowel Disease (Crohn’s Disease) and Rheumatoid Arthritis. Here we have discussed immunomodulation and signaling of the pathways involved, and the programmed cell death response. We have also covered the relationship of the immune response to autoimmune disorders and to cancer. The treatment of cancer now heavily leans toward the blocking of destructive processes in the immunomodulatory pathways.

Epilogue – Volume 2
Volume 2 has covered the most common bacterial and viral diseases that we find widely, or sporadically. It detailed the development of sepsis, and the immune response factor. The immune response involves local cellular invasion of lymphocytes related to initiation of T-cells and macrophages, and also the proteomic generated B-cell antibodies. These reactions are both local and systemic, as bacterial invasion is local and usually related to the tissue of residence (large intestine, oral, lung, genital). In the case of virus, the site of entry is often respiratory or by food intake, but these agents may rapidly become systemic. The other matter of the immune response is autoimmune, a reaction against the self. It is not entirely clear how this is initiated, but it has been related to failure to develop immunity in the prenatal or postnatal period. The only other possibility that might be considered would be by the mechanism of cell remodeling by an apoptotic related mechanism. The other chapters deal with therapeutics.

Epilogue – Volume 3
These two volumes have traversed a large knowledge-base. The first was directed largely at the well known bacterial, virus, fungal diseases, as well as autoimmunity. It specified recent FDA approved recommendations of pharmaceutics for these conditions. It also gives some attention to the immune response in inflammatory and autoimmune diseases, but not cancer. The second volume gives a concise history of development of Leukemias, Lymphomas pathology.

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Explore #Cancer #Cardiovascular #Immunology #Patient-Centered Medicine – BioMed e-Series 16 Volumes on Amazon.com

Editor-in-Chief, BioMed e-Series, LPBI Group

 

 

Our 11th e-Book NOW AVAILABLE ON AMAZON.COM SINCE 10/16/2017

https://www.amazon.com/dp/B076HGB6MZ

To see All the 11 e-Books of the 16-volume e-Series on Amazon.com, click on link 

https://www.amazon.com/s/ref=dp_byline_sr_ebooks_9?ie=UTF8&text=Aviva+Lev-Ari&search-alias=digital-text&field-author=Aviva+Lev-Ari&sort=relevancerank

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Inspiring Book for ALL Cancer Survivors, ALL Cancer Patients and ALL Cardiac Patients –  The VOICES of Patients, Hospitals CEOs, Health Care Providers, Caregivers and Families: Personal Experience with Critical Care and Invasive Medical Procedures

Editor-in-Chief, BioMed e-Series: Aviva Lev-Ari, PhD, RN

 

“The VOICES of Patients, Hospitals CEOs, Health Care Providers, Caregivers and Families: Personal Experience with Critical Care and Invasive Medical Procedures”

https://www.amazon.com/dp/B076HGB6MZ

CLICK, below for All the 11 we published on Amazon.com

https://www.amazon.com/s/ref=dp_byline_sr_ebooks_9?ie=UTF8&text=Aviva+Lev-Ari&search-alias=digital-text&field-author=Aviva+Lev-Ari&sort=relevancerank

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e-Scientific Publishing: The Competitive Advantage of a Powerhouse for Curation of Scientific Findings and Methodology Development for e-Scientific Publishing – LPBI Group, A Case in Point

Author and Editor-in-Chief: Aviva Lev-Ari, PhD RN

 

In this article I cover the Business Synopsis and the following Four Parts of the Business:

Part 1: The Vision

Part 2: Scientific Journal – Site Statistics on 6/20/2017

Part 3: BioMed e-Series

Part 4: Real Time Coverage of 50 Biotech Top Conferences

 

 

Synopsis

  • Interdisciplinary Journal covers interfaces of six domains

(Life sciences, Pharmaceuticals, Medicine, Healthcare Policy, Biotech Intelligence and Medical Devices)

  • Curations of Scientific Findings of peer reviewed articles in top three journals in each of the Six domain
  • Curations written on a multi-Authoring platform by MDs, MD/PhDs, PharmD and PhDs, all 15 years after graduation of the advanced degree program, and each has a publication list before joined my team – they write clinical and medical interpretations of the scientific frontier as evidenced in the Scientific Finding section of published articles in Cell, Nature, Science, NEJM, other top journals in these six domains.
  • Volume, ~5,150 Scientific articles, +500 categories of Research defining the Journal Ontology, 9,500 tags, 7,300, scientific comment on the articles submitted and exchange recorded between the Scientific community and our Team members
  • Top two articles >25,000 eReaders
  • Clicks on two Top Authors: >551,000
  • from NIH +3,700 hits
  • 2250 Journal subscribers by e-mail
  • +6,200 Biotech Executive following up on LinkedIn
  • BioMed e-Series: 16 volumes, 9 on Amazon.com

https://www.amazon.com/s/ref=dp_byline_sr_ebooks_9?ie=UTF8&text=Aviva+Lev-Ari&search-alias=digital-text&field-author=Aviva+Lev-Ari&sort=relevancerank

  • In House Developed Methodology for Real Time Press Coverage of Biotech Top International conferences – selective  topics covered at conferences lead to NEW Curations in the Journal

 

Part 1: The Vision

https://pharmaceuticalintelligence.com/vision/

Part 2: Scientific Journal – Site Statistics on 6/20/2017

https://pharmaceuticalintelligence.com/

1.3 Million eReaders on WordPress.com in 6/2017

Best ever daily views

2,508 views

Our DOMAINS in Scientific Media

I.  Pharmaceutical: Biologics, Small Molecules, Diagnostics

II.  Life Sciences: Genomics and Cancer Biology

III.  Patient-centered Medicine: Focus on #1: Cardiovascular, #2: Cancer, #3: Physiology: Metabolomics, Immunology

IV. Biomedicine, BioTech, and MedTech (Medical Devices)

V.  HealthCare: Patient-centered Medicine and Personalized/Precision Medicine

 

All time

1,236,276 eReaders & 1,239,246 on 6/25/2017

2,243 Subscribers by e-mail

7,270 Scientific comments

5,126 Scientific Articles

561 Categories of Research – Journal Ontology

9,591 Tags

Followers (includes Publicize)

790 Twitter

699 Facebook

67 Tumblr

Top Posts >3,000 Views for all days ending 2017-06-20 (Summarized)

Clicks for all days ending 2017-06-20 (Summarized)

Referrers All Time >1,000 from one Source

Referrer Views
Search Engines   641,404
linkedin.com   24,641
Facebook 7,042
lnkd.in 6,285
scholar.google.com 3,747
Twitter 3,134
android-app 1,100
investorshub.advfn.com 1,062

Content

Top Authors for all days ending 2017-06-20 (Summarized)

Our Team Authors Author Views
Aviva Lev-Ari, PhD RN 322,313
Larry H Bernstein, MD, FCAP 226,768
Tilda Barliya, PhD 48,229
Stephen J Williams, PhD 40,966
Dror Nir, PhD 24,975
Sudipta Saha, PhD 22,713
Ritu Saxena, PhD 15,448
Demet Sag, Ph.D., CRA, GCP 13,315
Aviral Vatsa, PhD 8,132
Ziv Raviv, PhD 7,649
zs22 3,874
Gail S Thornton, MA, PhD(c) 3,535
Anamika Sarkar, PhD 3,280
Danut Dragoi, PhD 2,746
Prabodh Kandala, PhD 2,118
Alan F. Kaul, PharmD., MS, MBA, FCCP 2,065
Aashir Awan, PhD 1,865
Justin D Pearlman, MD, PhD, FACC 1,467
Meg Baker, PhD 1,447
Irina Robu, PhD 969
S. Chakrabarti, Ph.D. 641
Ed Kislauskis, PhD 585
Howard Donohue, PhD 537
David Orchard-Webb, PhD 465
Evelina Cohn, PhD 371
Stuart Cantor, PhD 368
Marzan Khan, BSc – Research Associate 355
apreconasia, DVM 342
Jukka Karjalainen, MD, PhD 229
anayou1, PhD 224
Sreedhar Tirunagari, PhD 158
gerag2015, ESQ 112
Larry Mulligan , PhD 91
Kelly Perlman, BSc (c) Research Associate 66
Rosalind Codrington, PhD 32

Graphics for 4/2012 to 3/10/2015

Part 3: BioMed e-Series

  • The Methodology of Co-Curation


Image Source: Original Graphic Conceptualization of the Co-Curation Concept by Stephen J Williams, 3/10/2015

Titles in the BioMed e-Series: 16 e-Books in Medicine and Life Sciences

https://www.amazon.com/s/ref=dp_byline_sr_ebooks_9?ie=UTF8&text=Aviva+Lev-Ari&search-alias=digital-text&field-author=Aviva+Lev-Ari&sort=relevancerank

9 results for Kindle Store : “Aviva Lev-Ari”

  • Product Details

    Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics

    Nov 28, 2015 | Kindle eBook

    by Justin D. Pearlman MD ME PhD MA FACC and Stephen J. Williams PhD
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC
  • Product Details

    Cancer Therapies: Metabolic, Genomics, Interventional, Immunotherapy and Nanotechnology in Therapy Delivery (Series C Book 2)

    May 13, 2017 | Kindle eBook

    by Larry H. Bernstein and Demet Sag
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC
  • Product Details

    Perspectives on Nitric Oxide in Disease Mechanisms (Biomed e-Books Book 1)

    Jun 20, 2013 | Kindle eBook

    by Margaret Baker PhD and Aviva Lev-Ari PhD RN
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC
  • Product Details

    Cancer Biology and Genomics for Disease Diagnosis (Series C: e-Books on Cancer & Oncology Book 1)

    Aug 10, 2015 | Kindle eBook

    by Larry H Bernstein MD FCAP and Prabodh Kumar Kandala PhD
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC
  • Product Details

    Genomics Orientations for Personalized Medicine (Frontiers in Genomics Research Book 1)

    Nov 22, 2015 | Kindle eBook

    by Sudipta Saha PhD and Ritu Saxena PhD
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC
  • Product Details

    Metabolic Genomics & Pharmaceutics (BioMedicine – Metabolomics, Immunology, Infectious Diseases Book 1)

    Jul 21, 2015 | Kindle eBook

    by Larry H. Bernstein MD FCAP and Prabodah Kandala PhD
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC
  • Product Details

    Milestones in Physiology: Discoveries in Medicine, Genomics and Therapeutics (Series E: Patient-Centered Medicine Book 3)

    Dec 26, 2015 | Kindle eBook

    by Larry H. Bernstein MD FACP and Aviva Lev-Ari PhD RN
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC
  • Product Details

    Regenerative and Translational Medicine: The Therapeutic Promise for Cardiovascular Diseases

    Dec 26, 2015 | Kindle eBook

    by Justin D. Pearlman MD ME PhD MA FACC and Ritu Saxena PhD
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC
  • Product Details

    Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation: The Art of Scientific & Medical Curation

    Nov 29, 2015 | Kindle eBook

    by Larry H. Bernstein MD FCAP and Aviva Lev-Ari PhD RN
    Subscribers read for free.
    Auto-delivered wirelessly
    Sold by: Amazon Digital Services LLC

Forthcoming e-Books in 2017 & 2018

https://pharmaceuticalintelligence.com/biomed-e-books/

 

 

Analytics for the BioMed e-Series based on:

  1. Number of Articles per Volume
  2. E-Readers per Article
  3. Volume e-Impression since DATE of Publication [Summation of 2, above for all articles inside each Volume, before it was inside an e-Book and after the DATE of publication [Product details per Volume in attachment – Five e-Series – several Volumes per e-Series]

PENDING

 

Part 4: Real Time Coverage of 50 Biotech Top Conferences

https://pharmaceuticalintelligence.com/press-coverage/

 

Other related articles to e-Scientific Publishing include the following: 

 

 

 

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Ultra-Pure Melatonin Product Helps Maintain Sleep for Up to 7 Hours

Curator: Gail S. Thornton, M.A.

Co-Editor: The VOICES of Patients, Hospital CEOs, HealthCare Providers, Caregivers and Families: Personal Experience with Critical Care and Invasive Medical Procedures

 

The role of melatonin is important in regulating natural sleep and wake cycles. Typically, melatonin levels decline with age, significantly decreasing after age 40. An estimated 50 to 70 million Americans are affected by sleep difficulties – a process regulated by melatonin — and long-term sleep deprivation has been associated with negative health consequences, including an increased risk of diabetes, hypertension, heart attack, stroke, obesity, and depression.

Clinical data from a new pharmacokinetic study suggests that REMfresh®, the first and only continuous release and absorption melatonin (CRA-melatonin), helps maintain sleep for up to 7 hours. REMfresh® contains 99 percent ultra-pure melatonin and is sourced in Western Europe, a factor that is significant and important to many sleep specialists.

Three research abstracts on the REMfresh® data were published in an online supplement in the journal, Sleep, and were presented recently at the 31st Annual Meeting of the Associated Professional Sleep Societies LLC (APSS).

REMfresh Photo

Image SOURCE: Photograph courtesy of Physician’s Seal®

How REMfresh® Works

REMfresh® (CRA-melatonin) mimics the body’s own 7-hour Mesa Wave™, a natural pattern of melatonin blood levels during a normal night’s sleep cycle.

The study demonstrated the continuous release and absorption of 99 percent ultra-pure melatonin in REMfresh® (CRA-melatonin) was designed to induce sleep onset and provide continuous, lasting restorative sleep over 7 hours.

The scientifically advanced, patented formulation, called Ion Powered Pump (IPP™) technology, replicates the way in which the body naturally releases and absorbs melatonin, unlike conventional melatonin sleep products.

Since REMfresh® (CRA-melatonin) is not a drug, there is no drug hangover.

REMfresh MesaCurveNew-1

Image SOURCE: Diagram courtesy of Physician’s Seal®

 

Data Based on Scientifically Advanced Delivery Technology

According to the primary study author, David C. Brodner, M.D., “These study results represent an unparalleled breakthrough in drug-free, sleep maintenance that physicians and patients have been waiting for in a sleep product.” Dr. Brodner is a sleep specialist who is double board-certified in Otolaryngology – Head and Neck Surgery and Sleep Medicine and is the founder and principle physician at the Center for Sinus, Allergy, and Sleep Wellness in Palm Beach County, Florida.

Dr. Brodner said, “Melatonin products have been used primarily as a chronobiotic to address sleep disorders, such as jet lag and shift work. The patented delivery system in REMfresh mimics the body’s own natural sleep pattern, so individuals may experience consistent, restorative sleep and have an improved quality of life with this drug-free product.”

Study Findings With REMAKT

The study findings are based on REMAKT™ (REM Absorption Kinetics Trial), a U.S.-based randomized, crossover pharmacokinetic (PK) evaluation study in healthy, non-smoking adults that compared REMfresh® (CRA-melatonin) with a market-leading, immediate-release melatonin (IR-melatonin).

The study found that melatonin levels with REMfresh® exceeded the targeted sleep maintenance threshold for a median of 6.7 hours, compared with 3.7 hours with the leading IR-melatonin. Conversely, the levels of the market-leading IR-melatonin formulation dramatically increased 23 times greater than the targeted levels of exogenous melatonin for sleep maintenance and had a rapid decline in serum levels that did not allow melatonin levels to be maintained beyond 4 hours.

Additional analysis presented showed that REMfresh® (CRA-melatonin) builds upon the body of evidence from prolonged-release melatonin (PR-M), which demonstrated in well-conducted, placebo-controlled studies, statistically significant improvement in sleep quality, morning alertness, sleep latency and quality of life in patients aged 55 years and older compared with placebo.

REMfresh® (CRA-melatonin) was designed to overcome the challenges of absorption in the intestines, thereby extending the continual and gradual release pattern of melatonin through the night (known as the Mesa Wave™, a flat-topped hill with steep sides). There was a faster time to Cmax, which is anticipated to result in improved sleep onset, while the extended median plateau time to 6.7 hours and rapid fall-off in plasma levels at the end of the Mesa Wave™ may help to improve sleep maintenance and morning alertness.

REFERENCE/SOURCE

Physician’s Seal® and REMfresh® (www.remfresh.com)

REMfresh® press release, June 5, 2017 (http://www.prnewswire.com/news-releases/scientifically-advanced-delivery-technology-in-sleep-management-debuts-at-sleep-2017-with-clinical-data-showing-remfresh-the-first-and-only-continuous-release-and-absorption-melatonin-helps-maintain-sleep-for-up-to-7-hours-300468218.html)

Dr. David C. Brodner, Center for Sinus, Allergy, and Sleep Wellness  (http://www.brodnermd.com/sleep-hygiene.html)

Other related articles published in this Open Access Online Scientific Journal include the following:

2017

Sleep Research Society announces 2017 award recipients including Thomas S. Kilduff, PhD, Director, Center for Neuroscience at SRI International in Menlo Park, California

https://pharmaceuticalintelligence.com/2017/04/28/sleep-research-society-announces-2017-award-recipients-including-thomas-s-kilduff-phd-director-center-for-neuroscience-at-sri-international-in-menlo-park-california/

2016

Sleep Science

Genetic link to sleep and mood disorders

https://pharmaceuticalintelligence.com/2016/02/27/genetic-link-to-sleep-and-mood-disorders/

2015

Sleep quality, amyloid and cognitive decline

https://pharmaceuticalintelligence.com/2015/10/31/sleep-quality-amyloid-and-cognitive-decline/

2013

Day and Night Variation in Melatonin Level affects Plasma Membrane Redox System in Red Blood Cells

https://pharmaceuticalintelligence.com/2013/02/23/httpwww-ncbi-nlm-nih-govpubmed22561555/

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Who are the TOP Referrers for pharmaceuticalintelligence.com?

Reporter: Aviva Lev-Ari, PhD, RN

Referrers for all days ending 2017-05-09 (Summarized

 

All Time

Referrer Views
Search Engines   622,331
linkedin.com 24,335
Facebook 6,955
lnkd.in 6,267
scholar.google.com 3,657
Twitter 3,108
investorshub.advfn.com 1,036
android-app 949
WordPress Dashboard 908
scoop.it 803
mail.yahoo.com 765
scholar.google.co.in 485
scholar.google.co.uk 453
avanza.se 401
WordPress.com Reader 394
correio.portugalmail.pt/imp/ 381
36ohk6dgmcd1n-c.c.yom.mail.yahoo.net 348
scholar.google.co.jp 296
scholar.google.de 260
wcvb.com 249
feedly.com 246
Google+ 234
scholar.google.ca 231
touch.www.linkedin.com 195
scholar.google.com.au 187
coursewareobjects.elsevier.com/objects/McCance7e/mod08b/08s01l0113.html 162
scholar.google.fr 153
bioportfolio.com 145
synergyhealthconcepts.com/tvam-transvascular-autonomic-modulation/ 143
quetext.com 135
scholar.google.es 131
web.mail.comcast.net 128
scholar.google.nl 128
en.wikipedia.org 126
scholar.google.com.br 119
scholar.google.it 116
Google 115
delta-search.com 113
sp.astellasonline.net 109
lse.co.uk 105
scholar.google.com.pk 103

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