Advertisements
Feeds:
Posts
Comments

Archive for the ‘Scientific Publishing’ Category


Lesson 5 Cell Signaling And Motility: Cytoskeleton & Actin: Curations and Articles of reference as supplemental information: #TUBiol3373

Curator: Stephen J. Williams, Ph.D.

Cell motility or migration is an essential cellular process for a variety of biological events. In embryonic development, cells migrate to appropriate locations for the morphogenesis of tissues and organs. Cells need to migrate to heal the wound in repairing damaged tissue. Vascular endothelial cells (ECs) migrate to form new capillaries during angiogenesis. White blood cells migrate to the sites of inflammation to kill bacteria. Cancer cell metastasis involves their migration through the blood vessel wall to invade surrounding tissues.

Please Click on the Following Powerpoint Presentation for Lesson 4 on the Cytoskeleton, Actin, and Filaments

CLICK ON LINK BELOW

cell signaling 5 lesson

This post will be updated with further information when we get into Lesson 6 and complete our discussion on the Cytoskeleton

Please see the following articles on Actin and the Cytoskeleton in Cellular Signaling

Role of Calcium, the Actin Skeleton, and Lipid Structures in Signaling and Cell Motility

This article, constitutes a broad, but not complete review of the emerging discoveries of the critical role of calcium signaling on cell motility and, by extension, embryonic development, cancer metastasis, changes in vascular compliance at the junction between the endothelium and the underlying interstitial layer.  The effect of calcium signaling on the heart in arrhtmogenesis and heart failure will be a third in this series, while the binding of calcium to troponin C in the synchronous contraction of the myocardium had been discussed by Dr. Lev-Ari in Part I.

Universal MOTIFs essential to skeletal muscle, smooth muscle, cardiac syncytial muscle, endothelium, neovascularization, atherosclerosis and hypertension, cell division, embryogenesis, and cancer metastasis. The discussion will be presented in several parts:
1.  Biochemical and signaling cascades in cell motility
2.  Extracellular matrix and cell-ECM adhesions
3.  Actin dynamics in cell-cell adhesion
4.  Effect of intracellular Ca++ action on cell motility
5.  Regulation of the cytoskeleton
6.  Role of thymosin in actin-sequestration
7.  T-lymphocyte signaling and the actin cytoskeleton

 

Identification of Biomarkers that are Related to the Actin Cytoskeleton

In this article the Dr. Larry Bernstein covers two types of biomarker on the function of actin in cytoskeleton mobility in situ.

  • First, is an application in developing the actin or other component, for a biotarget and then, to be able to follow it as

(a) a biomarker either for diagnosis, or

(b) for the potential treatment prediction of disease free survival.

  • Second, is mostly in the context of MI, for which there is an abundance of work to reference, and a substantial body of knowledge about

(a) treatment and long term effects of diet, exercise, and

(b) underlying effects of therapeutic drugs.

Microtubule-Associated Protein Assembled on Polymerized Microtubules

(This article has a great 3D visualization of a microtuble structure as well as description of genetic diseases which result from mutations in tubulin and effects on intracellular trafficking of proteins.

A latticework of tiny tubes called microtubules gives your cells their shape and also acts like a railroad track that essential proteins travel on. But if there is a glitch in the connection between train and track, diseases can occur. In the November 24, 2015 issue of PNAS, Tatyana Polenova, Ph.D., Professor of Chemistry and Biochemistry, and her team at the University of Delaware (UD), together with John C. Williams, Ph.D., Associate Professor at the Beckman Research Institute of City of Hope in Duarte, California, reveal for the first time — atom by atom — the structure of a protein bound to a microtubule. The protein of focus, CAP-Gly, short for “cytoskeleton-associated protein-glycine-rich domains,” is a component of dynactin, which binds with the motor protein dynein to move cargoes of essential proteins along the microtubule tracks. Mutations in CAP-Gly have been linked to such neurological diseases and disorders as Perry syndrome and distal spinal bulbar muscular dystrophy.

 

Advertisements

Read Full Post »


Royalties in Kindle Unlimited and Kindle Owners’ Lending Library – A guide to publishing on Amazon

 

Royalties in Kindle Unlimited and Kindle Owners’ Lending Library

You’re eligible for royalty payment from Kindle Unlimited (KU, or Abonnement Kindle in France) and the Kindle Owners’ Lending Library (KOLL) for pages an individual customer reads in your book for the first time. A guide to publishing on Amazon

A customer can read your book as many times as they like, but we will only pay you for the number of pages read the first time the customer reads them. It may take months for customers to read pages in your book, but no matter how long it takes, we’ll still pay you once it happens. This is true even if your KDP Select enrollment period has expired, and you choose not to re-enroll.

Kindle Edition Normalized Page Count (KENPC v3.0)

To determine a book’s page count in a way that works across genres, devices, and display settings, we developed the Kindle Edition Normalized Page Count (KENPC). KENPC is calculated using standard formatting settings (font, line height, line spacing, etc.). We use KENPC to measure the number of pages customers read in your book, starting with the Start Reading Location (SRL) to the end of your book. Amazon typically sets SRL at chapter 1 so readers can start reading the core content of your book as soon as they open it. Non-text elements within books including images, charts and graphs will count toward a book’s KENPC.

KENPC v3.0
We released KENPC v3.0 to improve the way we measure how many pages of each book Kindle Unlimited and KOLL customers read. We’re constantly working to improve our programs and increase fairness of how we allocate the KDP Select Global Fund. These changes continue to improve the program and reward authors whose books are being borrowed and read the most by customers.

The KENPC v3.0 update applies uniformly to all KDP Select books and all versions of those books. Regardless of which version a customer may be reading, all future royalties will be paid using KENPC v3.0. If a customer previously borrowed your book and is still reading it, any new pages read will be based on KENPC v3.0.

Authors are able to earn a maximum of 3,000 Kindle Edition Normalized Pages (KENPs) read per title per customer. This means that each time your book is borrowed and read, you will receive credit for up to 3,000 pages. We believe this results in an equitable distribution of the KDP Select Global Fund.

Your book’s KENPC
You can see your book’s KENPC v3.0 listed on the “Promote and Advertise” page in your Bookshelf, and you can also see total pages read on your Sales Dashboard report. Because it’s based on default settings, KENPC v3.0 may vary from page counts listed on your Amazon detail page, which are derived from other sources.

KDP Select Global Fund
Our total payout from the KDP Select Global Fund will be unaffected by the transition to KENPC v3.0, and the amount you earn from the global fund will continue to be determined based on your share of total pages read by Kindle Unlimited (KU) and Kindle Owners’ Lending Library (KOLL) customers. The new KENPC version will be applied uniformly to all KDP Select books and used to measure all pages read.

 

Royalties

You’ll get one combined royalty payment for both KU and KOLL, paid according to the same payment schedule and payment method you selected for your other KDP sales.We review the size of the KDP Select Global Fund each month in order to make it compelling for authors to enroll their books in KDP Select. We announce the fund monthly in our community forum on kdp.amazon.com.The share of fund allocated to each country varies based on a number of factors, such as exchange rates, customer reading behavior, and local subscription pricing. Author earnings are then determined by their share of total pages read, up to a total of 3,000 pages per customer per title.

For example, here’s how we’d calculate royalty payout if $10 million in funds were available in a given month with 100 million total pages read (Note: Actual payouts vary and may be less; check your Prior Month’s Royalty Report to see your earnings):

  • Author with a 100 page bookthat was borrowed and read completely 100 times would earn $1,000 ($10 million multiplied by 10,000 pages for this author divided by 100,000,000 total pages).
  • Author of a 200 page bookthat was borrowed and read completely 100 times would earn $2,000 ($10 million multiplied by 20,000 pages for this author divided by 100,000,000 total pages).
  • Author of a 200 page bookthat was borrowed 100 times but only read halfway through on average would earn $1,000 ($10 million multiplied by 10,000 pages for this author divided by 100,000,000 total pages).

We always support our authors’ efforts to promote their books, but at the same time we work to prevent any manipulation of the Kindle platform.

We do not permit authors to offer, or participate in marketing that incentivizes Kindle Unlimited or Kindle Owners’ Lending Library customers to read their books in exchange for compensation of any kind. This includes payment (whether in the form of money or gift certificates), bonus content, entry to a contest or sweepstakes, discounts on future purchases, extra product, or other gifts.

Because we’re always looking to improve our authors’ experience, we have systems in place to monitor for potential manipulation.

 

Reporting

You can see your Kindle Edition Normalized Pages (KENP) Read in your Sales Dashboard report by marketplace and title. To see historical pages read, click “Generate Report” from your Sales Dashboard and go to the Orders Report tab.

If you’re enrolled in KDP Select, you will also see the following data on your reports:

Month-To-Date Unit Sales Report: The number of pages Kindle Unlimited or KOLL customers read of your books, under the “Kindle Edition Normalized Pages (KENP) Read” column.

Prior Months’ Royalties Report: For every title, there are five possible transaction types:

  • 35%:Amount a title earned under the 35% royalty option

  • 70%:Amount a title earned under the 70% royalty option

  • KDP Select Units:Amount every KDP Select-enrolled title earned monthly through Kindle Unlimited (KU) and the Kindle Owners’ Lending Library (KOLL). If a customer reads pages in your book for the first time through KU or KOLL, you will see a separate line item indicating the accumulated number of pages read under the column “Kindle Edition Normalized Pages (KENP) Read,” and the royalty earned through KU and KOLL under the “Royalty” column.

  • Free – Promotion:Free downloads due to Free promotion campaign(s) through KDP Select.

  • Free – Price Match:Free downloads due to competitor free price match.

 

SOURCE:  https://kdp.amazon.com/en_US/help/topic/G201541130

Read Full Post »


“If the whole world switches to open access since the scholarly community wants this, it would be a world without subscriptions”

Reporter: Aviva Lev-Ari, UC, Berkeley, PhD’83, Editor-in-Chief, PharmaceuticalIntelligence.com – Open Access since 4/2012, 1,585,184 e-Readers, 5,503 articles. @AVIVA1950 is followed by 360 who’s Followers are 2.5 Millions

 

Why did UC decide to end negotiations today?

Elsevier made a new, quite complex, but novel proposal to us at the end of January. On Monday, our negotiating team gave them a written response outlining our appreciation for Elsevier’s effort, but saying that conditions had to be met for us to sign a contract, and that we thought we were pretty far apart. We knew if they couldn’t accommodate us, there was not much point in continuing to negotiate at this time.

Elsevier wanted to keep meeting with us, and we have a meeting scheduled for tomorrow (Friday), but yesterday they approached our faculty directly — faculty who are editors of Elsevier journals, who they have working relationships with — and also the media, and presented a rosy view of the offer they’d made to us. Their characterization of the offer left things out, and they didn’t mention what we’d proposed as conditions. They went public with it. So, we announced the end.

We knew all along it was going to be difficult for Elsevier to change its ways to our satisfaction. We had hoped they’d see the light, that the publishing industry is changing, and that they could help lead the way.

What did each side want the most, and why?

From the very beginning, we had two goals: a reduction in costs — we pay about $11 million a year to Elsevier in subscription fees, which is 25 percent of UC system-wide journal costs — and default open access publication for UC authors: that is, that Elsevier would publish an author’s work open access unless the author didn’t want to. This is consistent with the UC faculty senate’s goal of all work being published open access.

We also wanted a contract that integrated a paid subscription with open access publishing fees. It would have been a transformative agreement, one that would shift payments for reading journal articles into payments for publishing them, and publishing them open access.

Elsevier eventually offered to do something like what we wanted, for open access, but they wanted to charge us a lot more. Our current calculations are that they would have increased the amount of our payments by 80 percent — an additional $30 million over a three-year contract.

Open access would eventually mean fewer subscriptions for Elsevier. But we don’t think they would lose, in the long run, by charging for publishing rather than by charging for reading. The transition the industry is making to open access is a feasible path forward, so that more universities don’t cancel their licenses for the same reasons we did.

If the whole world switches to open access, which we think it will at some point since the scholarly community wants this, it would be a world without subscriptions. But it would be a world where people would still want and need to publish their work in peer-reviewed journals, and there’s always a cost for that.

Doe Library

Berkeley’s University Library was a key player in negotiations with Elsevier. (Photo by J. Pierre Carrillo for the University Library)

Have other universities made the same decision?

In the U.S., we’re the first university system to do this with open access as the main issue.

But all of the universities in Germany canceled two years ago for the same reason. The Max Planck Society (the leading research organization in Germany) also did. The university alliance in Sweden canceled last spring, and the university alliance in Hungary canceled in December. Several other national alliances in Europe are trying to negotiate a similar contract with Elsevier.

Is this a goal of UC, to be a model institution for open access?

SOURCE

https://news.berkeley.edu/2019/02/28/why-uc-split-with-publishing-giant-elsevier/

 

Other related articles published in this Open Access Online Scientific Journal include the following:

University of California accounts for nearly 10% of all published research in the United States. It’s also a significant partner of Elsevier, which publishes about 18% of all UC output and collects more than 25% of the university’s $40-million overall subscription budget.

https://pharmaceuticalintelligence.com/2018/12/09/university-of-california-accounts-for-nearly-10-of-all-published-research-in-the-united-states-its-also-a-significant-partner-of-elsevier-which-publishes-about-18-of-all-uc-o/

Read Full Post »


eScientific Publishing a Case in Point: Evolution of Platform Architecture Methodologies and of Intellectual Property Development (Content Creation by Curation) Business Model

Author: Aviva Lev- Ari, PhD, RN

 

Six demonstrations that justify the claims made in our 2019 VISION:

https://pharmaceuticalintelligence.com/vision/

  • Point #1: Top Author, Chief Scientific Officer, MD, FCAP – share in the Journal’s archive computed
  • Point #2: Top authors by e-Readers per article – A Team at work
  • Point #3: Team members Led by Key Opinion Leader [https://lnkd.in/eEyn69r] generated Intellectual Property (IP) of Three Asset Classes
  • Point #4: Functions and Forms by Asset Class
  • Point #5: SYNERGY among the Three Asset Classes stimulates Value Creation
  • Point #6: Plan for Team membership augmentation and Training under existing Leadership and New Ownership

 

POINT #1: Top Author, Chief Scientific Officer, a retired Chief of Pathology, LHB, MD, FCAP – share in the Journal’s archive computed

Journal archive has 5,486 articles published

LHB has published 1,390 articles = 25.33% – he joined our team with a publication list of +200 articles in referred academic journals. LHB is co-curator of many articles with many of the team members

  • The Young Surgeon and The Retired Pathologist: On Science, Medicine and HealthCare Policy– The Best Writers Among the WRITERS

https://pharmaceuticalintelligence.com/2013/12/10/the-young-surgeon-and-the-retired-pathologist-on-science-medicine-and-healthcare-policy-best-writers-among-the-writers/

 

POINT #2: Top authors by e-Readers per article – A Team at work

Click on this link to review the contributions of Team members who’s articles achieved >1,000 Views.

  • Article Title, Author/Curator’s Name and Article Views >1,000, 4/2012 – 1/2019 @pharmaceuticalintelligence.com

https://pharmaceuticalintelligence.com/2019/01/30/article-title-author-curators-name-and-article-views-1000-4-2012-1-2018-pharmaceuticalintelligence-com/

 

POINT #3: Team members led by Key Opinion Leader (KOL) [https://lnkd.in/eEyn69r] generated Intellectual Property (IP) of Three Asset Classes

 

List of LPBI IP Assets by Asset Class representing a Team Effort

 

  • IP Asset Class I: Launched Open Access Online Scientific Journal @com, 4/2012

https://lnkd.in/erfbayJ

  •  IP Asset Class II: Launched BioMed eSeries, 16-Volumes in Life Sciences and Medicine, 10/2012

BioMed e-Series: 16 Volumes – electronic Table of Contents (eTOCs) of each Volume

https://pharmaceuticalintelligence.com/2017/12/12/biomed-e-series-16-volumes-electronic-table-of-contents-of-each-volume/


Launched 6 Volumes Cardiovascular Diseases e-Series, Bundled on Amazon for $515

https://lnkd.in/e6WkMgF

Launched 10 Volumes in Medicine: Genomics 1,2  Cancer 1,2 Immunology 1,2,3  Precision Medicine 1,2,3,4

https://lnkd.in/ekWGNqA

 

  • IP Asset Class III: Launched Real Time Press Coverage of Biotech Conferences, 3/2013

https://pharmaceuticalintelligence.com/press-coverage/

Part One: The Process of Real Time Coverage using Social Media

Part Two: List of BioTech Conferences 2013 to Present

Part Three: Conference eProceedings DELIVERABLES & Social Media Analytics

 

POINT #4: FUNCTIONS and FORMS by ASSET CLASS

 

LPBI Group’s IP:VENTURE’s Future Potential
IP Asset Class I
https://lnkd.in/erfbayJ
IP Asset Class II
https://lnkd.in/ekWGNqA
IP Asset Class III
https://pharmaceuticalintelligence.com/press-coverage/
Open Access Journal– M1.5 e-Readers,- 5.5K articles- 670 categories,- 7.3K comments- 10K Tags
BioMed E-Series– 16 Volumes- 5 Specialties in Medicine- 6 Volumes Cardiovascular Diseases e-Series, Bundled on Amazon for $515https://lnkd.in/e6WkMgF
Real Time Coverage BioTech/Medicine Conferences– eProceedings- Real Time Tweets on- Two Twitter Handles- Conference Hash Tags@pharma_BI@AVIVA1950- Part Two: List of BioTech Conferences 2013 to Present
Editor-in-Chief’sLeadership:- Senior Editors- Our Team
Our Team’s Product
https://pharmaceuticalintelligence.com/contributors-biographies/
Senior Editors’ Product with Our Team
https://pharmaceuticalintelligence.com/contributors-biographies/senior-editors/https://pharmaceuticalintelligence.com/contributors-biographies/
Editor-in-Chief’s Initiative
https://lnkd.in/eEyn69r
Architecture   Methodologies for ourPlatforms
·       Multi-Authoring Platform – wordpress.com·       Authoring Privilege levels·       Categories of research forming the Journal’s Ontology, a Dynamic Relational and Hierarchical database Multi-Authoring architecture·       Generation of new categories by authors developing the categories they are Owners of·       Article update policy
·       eTOCs design by Editors·       e-Book Style uniformity across all eSeries·       Structure of eBook Parts·       Structure of Chapters·       Structure of Articles·       Commission of Articles Specifically for given e-Books by Editor-in-Chief·       Overarching guidance for e-Books within each eSeries and across eSeries
·       Part One: The Process of Real Time Coverage using Social Media·       Methodology for Conference Coverage using Social Media: 2014 MassBio Annual Meeting 4/3 – 4/4 2014, Royal Sonesta Hotel, Cambridge, MA·       Template Development Process·       Channels of Social Media Development
Business ModelDevelopment: Content Creation by Curation of Scientific Findings
·       Author/Curator initiated article·       Article Commissions by Editor-in-Chief·       Co-Curations·       Research Category Ownership·       e-Books Editors role defined (Job description)
·       e-Books in Kindle Store·       30,000 Oncologists in the US·       40,000 Cardiologists in the US·       All Primary Care Physicians·       All Medical Schools for Curriculum development·       Global market for Medical EducationALL BioMed 16 Volumes [$515+$190+$175+$190+$274 = $1,344]@Amazon BUNDLED 6 Volumes Cardiovascular Diseases for $515https://lnkd.in/e6WkMgF@Amazon UNBUNDLED 10 Volumeshttps://lnkd.in/ekWGNqA·       Genomics 1,2 ($190)·       Cancer 1,2 ($175)·       Metabolomics, Immunology, Infectious Diseases 1,2,3 (#190)·       Precision Medicine 1,2,3,4 ($274)
·       The market is defined as “All Biotech Conferences Organizers around the Globe” in need to own eProceedings for their Conferences for electronic dissemination to conference attendees.·       Digital Archive of Conferences eProceedingsPart Three: Conference eProceedings DELIVERABLES & Social Media Analytics
 
IP Asset Class III
https://pharmaceuticalintelligence.com/press-coverage/
Real Time Coverage BioTech/Medicine Conferences
– eProceedings
– Real Time Tweets on
– Two Twitter Handles
– Conference Hash Tags
@pharma_BI
@AVIVA1950
Part Two: List of BioTech Conferences 2013 to Present
Editor-in-Chief’s Initiative
https://lnkd.in/eEyn69r
·       Part One: The Process of Real Time Coverage using Social Media
·       Methodology for Conference Coverage using Social Media: 2014 MassBio Annual Meeting 4/3 – 4/4 2014, Royal Sonesta Hotel, Cambridge, MA
·       Template Development Process
·       Channels of Social Media Development
·       The market is defined as “All Biotech Conferences Organizers around the Globe” in need to own eProceedings for their Conferences for electronic dissemination to conference attendees.
·       Digital Archive of Conferences eProceedings
Part Three: Conference eProceedings DELIVERABLES & Social Media Analytics

POINT #4 (IN DETAIL): Functions and Forms by Asset Class

 

IP Asset Class I: The Journal

 

The Methodology of Curation for Scientific Research Findings

https://pharmaceuticalintelligence.com/2014/07/30/the-methodology-of-curation-for-scientific-research-findings/

 

>> Evolution of Platform Architecture Methodologies: 

  • Multi-Authoring Platform – wordpress.com
  • Authoring Privilege levels
  • Categories of research forming the Journal’s Ontology, a Dynamic Relational and Hierarchical database Multi-Authoring architecture
  • Generation of new categories by authors developing the categories they are Owners of
  • Article update policy

 

>> Intellectual Property Development (Content Creation by Curation) Business Model 

  • Author/Curator initiated article
  • Article Commissions by Editor-in-Chief
  • Co-Curations
  • Research Category Ownership
  • e-Books Editors role defined (Job description)

 

IP Asset Class II: BioMed e-Series

 

> Evolution of Platform Architecture Methodologies

Cardiovascular Original Research: Cases in Methodology Design for Content Curation and Co-Curation

https://pharmaceuticalintelligence.com/2013/07/29/cardiovascular-original-research-cases-in-methodology-design-for-content-curation-and-co-curation/

  • eTOCs design by Editors
  • e-Book Style uniformity across all eSeries
  • Structure of eBook Parts
  • Structure of Chapters
  • Structure of Articles
  • Commission of Articles Specifically for given e-Books by Editor-in-Chief
  • Overarching guidance for e-Books within each eSeries and across eSeries

 

> Intellectual Property Development (Content Creation by Curation) Business Model 

 

  • e-Books in Kindle Store
  • 30,000 Oncologists in the US
  • 40,000 Cardiologists in the US
  • US & Global markets for Cardiology, Genomics, Cancer, Immunology, Infectious Diseases, Precision Medicine
  • All Primary Care Physicians
  • All Medical Schools for Curriculum development
  • Global market for Medical Education

 

ALL BioMed 16 Volumes [$515+$190+$175+$190+$274 = $1,344]

@Amazon BUNDLED 6 Volumes Cardiovascular Diseases for $515 https://lnkd.in/e6WkMgF

@Amazon UNBUNDLED 10 Volumes in #Medicine https://lnkd.in/ekWGNqA

  • Genomics 1,2 ($190)
  • Cancer 1,2 ($175)
  • Metabolomics, Immunology, Infectious Diseases 1,2,3 (#190)
  • Precision Medicine 1,2,3,4 ($274)

 

Series A – Cardiovascular Diseases – 6 volumes $515

 

Series B – Genomics 1,2  – 2 volumes $190

  • VOLUME 1: Genomics Orientations for Personalized Medicine. On comsince 11/23/2015

http://www.amazon.com/dp/B018DHBUO6

  • VOLUME 2: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS & BioInformatics, Simulations and the Genome Ontology

https://pharmaceuticalintelligence.com/biomed-e-books/genomics-orientations-for-personalized-medicine/volume-two-genomics-methodologies-ngs-bioinformatics-simulations-and-the-genome-ontology/

Volume 2 is Work-in-Progress To Be Published in 6/2019 at $115

 

Series C – Cancer & Oncology $175 

  • VOLUME 1 Cancer Biology Genomics

http://www.amazon.com/dp/B013RVYR2K

  • VOLUME 2 Therapies Genomics Interventional Immunotherapy Nanotechnology in Drug Delivery

http://www.amazon.com/dp/B071VQ6YYK

 

Series D – Metabolomics, Immunology, Infectious Diseases $190

  • VOLUME 1 Metabolomics

http://www.amazon.com/dp/B012BB0ZF0

  • VOLUME 2 Infectious Diseases & VOLUME 3 Immunology

https://www.amazon.com/dp/B075CXHY1B

 

Series E Precision Medicine – Four Volumes, Volumes 1,2,3,4 at $274

  • Patients Voices

https://www.amazon.com/dp/B076HGB6MZ

  • Physiology and Therapeutics

https://www.amazon.com/dp/B078313281

  • Medical Discoveries: Genomics Therapeutics

http://www.amazon.com/dp/B019VH97LU

  • 3D #BioPrinting in Medicine for Precision Medicine

https://www.amazon.com/dp/B078QVDV2W

 

IP Asset Class III: Real Time Coverage of BioTech Conferences

 

>> Evolution of Platform Architecture Methodologies

https://pharmaceuticalintelligence.com/2014/04/07/methodology-for-conference-coverage-using-social-media-2014-massbio-annual-meeting-43-44-2014-royal-sonesta-hotel-cambridge-ma/

  • Template Development Process
  • Channels of Social Media Development

 

>> Intellectual Property Development (Content Creation by Curation) Business Model 

  • The market is defined as “All Biotech Conferences Organizers around the Globe” in need to own eProceedings for their Conferences for electronic dissemination to conference attendees.
  • Digital Archive of Conferences eProceedings

 

POINT #5: SYNERGY among the Three Asset Classes stimulates Value Creation

 

  • Concepts from +60 Conferences I covered yielded ~300 new articles, five new per conference, at least
  • Electronic Table of Contents [eTOCs] for each e-Book of the [1,2,3..,16] is derived from the Research categories of the Journal
  • Journal Ontology has 700 Research Categories – knowledge architecture designed by experts
  • Every article in the Journal is connected with Social Media Icons on wordpress.com as an engine for
  1. Pingbacks
  2. New eReaders
  3. Scientists applying to author for the Journal
  4. +7,300 Scientific comments on 5,486 articles published – AGORA  

Electronic Scientific AGORA: Comment Exchanges by Global Scientists on Articles published in the Open Access Journal @pharmaceuticalintelligence.com – Four Case Studies

https://pharmaceuticalintelligence.com/2018/04/10/electronic-scientific-agora-comment-exchanges-by-global-scientists-on-articles-published-in-the-open-access-journal-pharmaceuticalintelligence-com-four-case-studies/

 

POINT #6: Plan for Team membership augmentation and Training under existing Leadership and New Ownership

Work-in-Progress

 

 

Other related articles published in this Open Access Online Scientific Journal include the following: 

 

Innovations in electronic Scientific Publishing (eSP): Case Studies in Marketing eContent, Curation Methodology, Categories of Research Functions, Interdisciplinary conceptual innovations by Cross Section of Categories, Exposure to Frontiers of Science by Real Time Press coverage of Scientific Conferences

https://pharmaceuticalintelligence.com/2017/05/06/case-studies-of-innovations-in-electronic-scientific-publishing-esp-marketing-econtent-curation-methodology-categories-of-research-functions-interdisciplinary-conceptual-innovations-by-cross-sec/

 

e-Scientific Publishing: The Competitive Advantage of a Powerhouse for Curation of Scientific Findings and Methodology Development for e-Scientific Publishing – LPBI Group, A Case in Point

https://pharmaceuticalintelligence.com/2017/06/20/e-scientific-publishing-the-competitive-advantage-of-a-powerhouse-for-curation-of-scientific-findings-and-methodology-development-for-e-scientific-publishing-lpbi-group-a-case-in-point/

 

The Methodology of Curation for Scientific Research Findings

https://pharmaceuticalintelligence.com/2014/07/30/the-methodology-of-curation-for-scientific-research-findings/

 

@PharmaceuticalIntelligence.com – A Case Study on the LEADER in Curation of Scientific Findings

https://pharmaceuticalintelligence.com/2017/06/29/pharmaceuticalintelligence-com-a-case-study-on-the-leader-in-curation-of-scientific-findings/

 

Curation of Scientific Content @Leaders in Pharmaceutical Business Intelligence (LPBI) Group, Boston

https://pharmaceuticalintelligence.com/2016/08/15/curation-of-scientific-content-leaders-in-pharmaceutical-business-intelligence-lpbi-group-boston/

 

Scientific Curation Fostering Expert Networks and Open Innovation: Lessons from Clive Thompson

https://pharmaceuticalintelligence.com/2014/07/17/scientific-curation-fostering-expert-networks-and-open-innovation-lessons-from-clive-thompson-and-others/

 

Cardiovascular Diseases and Pharmacological Therapy: Curations by Aviva Lev-Ari, PhD, RN, 2006 – 4/2018

https://pharmaceuticalintelligence.com/2014/04/17/cardiovascular-diseases-and-pharmacological-therapy-curations-by-aviva-lev-ari-phd-rn/

 

Methodology for Conference Coverage using Social Media: 2014 MassBio Annual Meeting 4/3 – 4/4 2014, Royal Sonesta Hotel, Cambridge, MA

https://pharmaceuticalintelligence.com/2014/04/07/methodology-for-conference-coverage-using-social-media-2014-massbio-annual-meeting-43-44-2014-royal-sonesta-hotel-cambridge-ma/

 

Cardiovascular Original Research: Cases in Methodology Design for Content Curation and Co-Curation

https://pharmaceuticalintelligence.com/2013/07/29/cardiovascular-original-research-cases-in-methodology-design-for-content-curation-and-co-curation/

 

 

 

 

Read Full Post »


Article Title, Author/Curator’s Name and Article Views >1,000, 4/2012 – 1/2019 @pharmaceuticalintelligence.com

 

Reporter: Aviva Lev-Ari, PhD, RN

 

Expert, Author, Writer’s Initials

Name & Bio

Roles

@LPBI Group

LHB Larry Bernstein, MD, FACP,

 

Member of the Board

Expert, Author, Writer – All Specialties of Medicine & Pathology

Content Consultant to Series B,C,D,E

Editor, Series D, Vol. 1, Series E, Vols 2,3,

Co-Editor – BioMed E-Series 13 of the 16 Vols

JDP Justin D. Pearlman, AB, MD, ME, PhD, MA, FACC,

 

Expert, Author, Writer, All Specialties of Medicine, Cardiology and Cardiac Imaging

Content Consultant for SERIES A, Cardiovascular Diseases Co-Editor: Vols 2,3,4,5,6

ALA Aviva Lev-Ari, PhD, RN,

-Ex – SRI, Int’l

-Ex – MITRE

-Ex – McGraw-Hill

Director and Founder

Editor-in-Chief, @pharmaceuticalintelligence.com

Methodologies Developer:

  • Journal Platform Architect,
  • CURATION of Scientific Findings Modules,
  • REALTIME eProceedings Digital 1-Click Publishing

Expert, Author, Writer:

  • Analytics
  • Molecular Cardiology
  • Vascular Biology
TB Tilda Barliya, PhD,

@BIU

Expert, Author, Writer: Nanotechnology for Drug Delivery

Co-Editor, Series C, Vols. 1,2

DN Dror Nir, PhD,

 

Expert, Author, Writer: Cancer & Medical Imaging Algorithms
ZR       
Ziv Raviv, PhD,
@Technion
Expert, Author, Writer: Biological Sciences, Cancer
ZS Zohi Sternberg, PhD, Expert, GUEST Author, Writer

 

Expert, GUEST Author, Writer

Neurological Sciences

SJW Stephen J. Williams, PhD Pharmacology, BSc Toxicology

Ex-Fox Chase

EAW – Cancer Biology

Co-Editor, Series A, Vol.1

Co-Editor, Series B, Genomics: Vols. 1,2

Co-Editor, Series C, Cancer, Vols. 1,2

DS Demet Sag, PhD, CRA, GCP,

 

Expert, Author, Writer: Genome Biology, Immunology, Biological Sciences: Cancer
SS Sudipta Saha, PhD,

 

Expert, Author, Writer: Reproductive Biology, Endocrinology, Bio-Instrumentation

Co-Editor, Series D, Volume 2, Infectious Diseases

AV Aviral Vatsa, PhD, MBBS

 

Expert, Author, Writer: Medical Sciences, Bone Disease, Human Sensation and Cellular Transduction: Physiology and Therapeutics

 

RS Ritu Saxena, PhD,

 

Expert, Author, Writer: Biological Sciences, Bone Disease, Cancer (Lung, Liver)
GST Gail S. Thornton, PhD(c),

Ex-MERCK

Contributing Editor, Author and Medical Writer

Co-Editor, Series E, Vol.1 Voices of Patients

RN Raphael Nir, PhD, MSM, MSc

Ex-ScheringPlough

– Expert, Author, Writer – Member of the Cancer Research Team: Brain Cancer, Liver Cancer, Cytokines

– CSO, SBH Sciences, Inc.

MB Michael R. Briggs, Ph.D.

Ex-Pfizer

– Expert, Author, Writer – Member of the Cancer Research Team: NASH

– CSO, Woodland Biosciences

AK Alan F. Kaul, R.Ph., Pharm.D, M.Sc., M.B.A., FCCP, Expert, Author, Writer

Ex-Director BWH Pharmacy

Expert, Author, Writer: Pharmacology – all aspects of Drug development and dispensation, Policy analyst
AS Anamika Sarkar, PhD,

 

Expert, Author, Writer: Computation Biology & Bioinformatics
MWF Marcus Feldman, PhD,

Stanford University, Biological Sciences, Center for Genomics

751
Research items
51,402
Reads
39,126
Citations
Member of the Board,

Scientific Counsel: Life Sciences,

Content Consultant Series B, Genomics, Vols. 1,2

Co-Editor, Vol. 2, NGS

 

Article Title and Views >1,000,

4/2012 – -1/2018

 

 

 

 

Home page / Archives

Authors

Curators

Reporters

by Name

 

Views

by 

eReaders

 

 

 

 

 

600,145

Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View? LHB 16,720
Do Novel Anticoagulants Affect the PT/INR? The Cases of XARELTO (rivaroxaban) and PRADAXA (dabigatran)

JDP

ALA

13,225
Paclitaxel vs Abraxane (albumin-bound paclitaxel) TB 11,872
Recent comprehensive review on the role of ultrasound in breast cancer management DN 11,715
Clinical Indications for Use of Inhaled Nitric Oxide (iNO) in the Adult Patient Market: Clinical Outcomes after Use, Therapy Demand and Cost of Care ALA 7,045
Apixaban (Eliquis): Mechanism of Action, Drug Comparison and Additional Indications ALA 6,435
Mesothelin: An early detection biomarker for cancer (By Jack Andraka) TB 6,309
Our TEAM ALA 6,213
Akt inhibition for cancer treatment, where do we stand today? ZR 4,744
Biochemistry of the Coagulation Cascade and Platelet Aggregation: Nitric Oxide: Platelets, Circulatory Disorders, and Coagulation Effects LHB 4,508
Newer Treatments for Depression: Monoamine, Neurotrophic Factor & Pharmacokinetic Hypotheses ZS 4,188
AstraZeneca’s WEE1 protein inhibitor AZD1775 Shows Success Against Tumors with a SETD2 mutation SJW 4,128
Confined Indolamine 2, 3 dioxygenase (IDO) Controls the Hemeostasis of Immune Responses for Good and Bad DS 3,678
The Centrality of Ca(2+) Signaling and Cytoskeleton Involving Calmodulin Kinases and Ryanodine Receptors in Cardiac Failure, Arterial Smooth Muscle, Post-ischemic Arrhythmia, Similarities and Differences, and Pharmaceutical Targets LHB 3,652
FDA Guidelines For Developmental and Reproductive Toxicology (DART) Studies for Small Molecules SJW 3,625
Cardiovascular Diseases, Volume One: Perspectives on Nitric Oxide in Disease Mechanisms Multiple

Authors

3,575
Interaction of enzymes and hormones SS 3,546
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo SJW 3,403
Causes and imaging features of false positives and false negatives on 18F-PET/CT in oncologic imaging DN 3,399
Introduction to Transdermal Drug Delivery (TDD) system and nanotechnology TB 3,371
Founder ALA 3,363
BioMed e-Series ALA 3,246
Signaling and Signaling Pathways LHB 3,178
Sexed Semen and Embryo Selection in Human Reproduction and Fertility Treatment SS 3,044
Alternative Designs for the Human Artificial Heart: Patients in Heart Failure – Outcomes of Transplant (donor)/Implantation (artificial) and Monitoring Technologies for the Transplant/Implant Patient in the Community

JDP

LHB

ALA

3,034
The mechanism of action of the drug ‘Acthar’ for Systemic Lupus Erythematosus (SLE) Dr. Karra 3,016
VISION ALA 2,988
Targeting the Wnt Pathway [7.11] LHB 2,961
Bone regeneration and nanotechnology AV 2,922
Pacemakers, Implantable Cardioverter Defibrillators (ICD) and Cardiac Resynchronization Therapy (CRT) ALA 2,892
The History and Creators of Total Parenteral Nutrition LHB 2,846
Funding, Deals & Partnerships ALA 2,708
Paclitaxel: Pharmacokinetic (PK), Pharmacodynamic (PD) and Pharmacogenpmics (PG) TB 2,700
LIK 066, Novartis, for the treatment of type 2 diabetes LHB 2,693
FDA Adds Cardiac Drugs to Watch List – TOPROL-XL® ALA 2,606
Mitochondria: Origin from oxygen free environment, role in aerobic glycolysis, metabolic adaptation LHB 2,579
Nitric Oxide and Platelet Aggregation Dr. Karra 2,550
Treatment Options for Left Ventricular Failure – Temporary Circulatory Support: Intra-aortic balloon pump (IABP) – Impella Recover LD/LP 5.0 and 2.5, Pump Catheters (Non-surgical) vs Bridge Therapy: Percutaneous Left Ventricular Assist Devices (pLVADs) and LVADs (Surgical) LHB 2,549
Isoenzymes in cell metabolic pathways LHB 2,535
“The Molecular pathology of Breast Cancer Progression” TB 2,491
In focus: Circulating Tumor Cells RS 2,465
Nitric Oxide Function in Coagulation – Part II LHB 2,444
Monoclonal Antibody Therapy and Market DS 2,443
Update on FDA Policy Regarding 3D Bioprinted Material SJW 2,410
Journal PharmaceuticalIntelligence.com ALA 2,340
A Primer on DNA and DNA Replication LHB 2,323
Pyrroloquinoline quinone (PQQ) – an unproved supplement LHB 2,294
Integrins, Cadherins, Signaling and the Cytoskeleton LHB 2,265
Evolution of Myoglobin and Hemoglobin LHB 2,251
DNA Structure and Oligonucleotides LHB 2,187
Lipid Metabolism LHB 2,176
Non-small Cell Lung Cancer drugs – where does the Future lie? RS 2,143
Biosimilars: CMC Issues and Regulatory Requirements ALA 2,101
The SCID Pig: How Pigs are becoming a Great Alternate Model for Cancer Research SJW 2,092
About ALA 2,076
Sex Hormones LHB 2,066
CD47: Target Therapy for Cancer TB 2,041
Peroxisome proliferator-activated receptor (PPAR-gamma) Receptors Activation: PPARγ transrepression for Angiogenesis in Cardiovascular Disease and PPARγ transactivation for Treatment of Diabetes ALA 2,017
Swiss Paraplegic Centre, Nottwil, Switzerland – A World-Class Clinic for Spinal Cord Injuries GST 1,989
Introduction to Tissue Engineering; Nanotechnology applications TB 1,964
Problems of vegetarianism SS 1,940
The History of Infectious Diseases and Epidemiology in the late 19th and 20th Century LHB 1,817
The top 15 best-selling cancer drugs in 2022 & Projected Sales in 2020 of World’s Top Ten Oncology Drugs ALA 1,816
Nanotechnology: Detecting and Treating metastatic cancer in the lymph node TB 1,812
Unique Selling Proposition (USP) — Building Pharmaceuticals Brands ALA 1,809
Wnt/β-catenin Signaling [7.10] LHB 1,777
The role of biomarkers in the diagnosis of sepsis and patient management LHB 1,766
Neonatal Pathophysiology LHB 1,718
Nanotechnology and MRI imaging TB 1,672
Cardiovascular Complications: Death from Reoperative Sternotomy after prior CABG, MVR, AVR, or Radiation; Complications of PCI; Sepsis from Cardiovascular Interventions JDP

ALA

1,659
Ultrasound-based Screening for Ovarian Cancer DN 1,655
Justin D. Pearlman, AB, MD, ME, PhD, MA, FACC, Expert, Author, Writer, Editor & Content Consultant for e-SERIES A: Cardiovascular Diseases JDP 1,653
Scientific and Medical Affairs Chronological CV ALA 1,619
Competition in the Ecosystem of Medical Devices in Cardiac and Vascular Repair: Heart Valves, Stents, Catheterization Tools and Kits for Open Heart and Minimally Invasive Surgery (MIS) ALA 1,609
Stenting for Proximal LAD Lesions ALA 1,603
Mitral Valve Repair: Who is a Patient Candidate for a Non-Ablative Fully Non-Invasive Procedure? JDP

ALA

1,602
Nitric Oxide, Platelets, Endothelium and Hemostasis (Coagulation Part II) LHB 1,597
Outcomes in High Cardiovascular Risk Patients: Prasugrel (Effient) vs. Clopidogrel (Plavix); Aliskiren (Tekturna) added to ACE or added to ARB LHB 1,588
Diet and Diabetes LHB 1,572
Clinical Trials Results for Endothelin System: Pathophysiological role in Chronic Heart Failure, Acute Coronary Syndromes and MI – Marker of Disease Severity or Genetic Determination? ALA 1,546
Dealing with the Use of the High Sensitivity Troponin (hs cTn) Assays LHB 1,540
Biosimilars: Intellectual Property Creation and Protection by Pioneer and by Biosimilar Manufacturers ALA 1,534
Altitude Adaptation LHB 1,527
Baby’s microbiome changing due to caesarean birth and formula feeding SS 1,498
Interview with the co-discoverer of the structure of DNA: Watson on The Double Helix and his changing view of Rosalind Franklin ALA 1,488
Triple Antihypertensive Combination Therapy Significantly Lowers Blood Pressure in Hard-to-Treat Patients with Hypertension and Diabetes ALA 1,476
IDO for Commitment of a Life Time: The Origins and Mechanisms of IDO, indolamine 2, 3-dioxygenase DS 1,469
CRISPR/Cas9: Contributions on Endoribonuclease Structure and Function, Role in Immunity and Applications in Genome Engineering LHB 1,468
Cancer Signaling Pathways and Tumor Progression: Images of Biological Processes in the Voice of a Pathologist Cancer Expert LHB 1,452
Signaling transduction tutorial LHB 1,443
Diagnostic Evaluation of SIRS by Immature Granulocytes LHB 1,440
UPDATED: PLATO Trial on ACS: BRILINTA (ticagrelor) better than Plavix® (clopidogrel bisulfate): Lowering chances of having another heart attack ALA 1,426
Cardio-oncology and Onco-Cardiology Programs: Treatments for Cancer Patients with a History of Cardiovascular Disease ALA 1,424
Nanotechnology and Heart Disease TB 1,419
Aviva Lev-Ari, PhD, RN, Director and Founder ALA 1,416
Cardiotoxicity and Cardiomyopathy Related to Drugs Adverse Effects LHB 1,415
Nitric Oxide and it’s impact on Cardiothoracic Surgery TB 1,405
A New Standard in Health Care – Farrer Park Hospital, Singapore’s First Fully Integrated Healthcare/Hospitality Complex GST 1,402
Mitochondrial Damage and Repair under Oxidative Stress LHB 1,398
Ovarian Cancer and fluorescence-guided surgery: A report TB 1,395
Sex determination vs. Sex differentiation SS 1,393
LPBI Group ALA 1,372
Closing the Mammography gap DN 1,368
Cytoskeleton and Cell Membrane Physiology LHB 1,367
Crucial role of Nitric Oxide in Cancer RS 1,364
Medical 3D Printing ALA 1,332
Survivals Comparison of Coronary Artery Bypass Graft (CABG) and Percutaneous Coronary Intervention (PCI) / Coronary Angioplasty LHB 1,325
The Final Considerations of the Role of Platelets and Platelet Endothelial Reactions in Atherosclerosis and Novel Treatments LHB 1,310
Disruption of Calcium Homeostasis: Cardiomyocytes and Vascular Smooth Muscle Cells: The Cardiac and Cardiovascular Calcium Signaling Mechanism

LHB

JDP

ALA

1,301
Mitochondrial Dynamics and Cardiovascular Diseases RS 1,284
Nitric Oxide and Immune Responses: Part 2 AV 1,282
Liver Toxicity halts Clinical Trial of IAP Antagonist for Advanced Solid Tumors SJW 1,269
Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells using a bacterial CRISPR/Cas ALA 1,261
Autophagy LHB 1,255
Mitochondrial fission and fusion: potential therapeutic targets? RS 1,246
Summary of Lipid Metabolism LHB 1,239
Nitric Oxide has a Ubiquitous Role in the Regulation of Glycolysis – with a Concomitant Influence on Mitochondrial Function LHB 1,233
Future of Calcitonin…? Dr. Karra 1,211
Transcatheter Aortic Valve Implantation (TAVI): FDA approves expanded indication for two transcatheter heart valves for patients at intermediate risk for death or complications associated with open-heart surgery ALA 1,197
Gamma Linolenic Acid (GLA) as a Therapeutic tool in the Management of Glioblastoma

RN

MB

1,193
Nanotechnology and HIV/AIDS Treatment TB 1,181
Patiromer – New drug for Hyperkalemia ALA 1,179
‘Gamifying’ Drug R&D: Boehringer Ingelheim, Sanofi, Eli Lilly ALA 1,177
A Patient’s Perspective: On Open Heart Surgery from Diagnosis and Intervention to Recovery Guest Author: Ferez S. Nallaseth, Ph.D. 1,173
Assessing Cardiovascular Disease with Biomarkers LHB 1,167
Development Of Super-Resolved Fluorescence Microscopy LHB 1,166
Ubiquitin-Proteosome pathway, Autophagy, the Mitochondrion, Proteolysis and Cell Apoptosis: Part III LHB 1,162
Atrial Fibrillation contributing factor to Death, Autopsy suggests CEO Dave Goldberg had heart arrhythmia before death ALA 1,159
Linus Pauling: On Lipoprotein(a) Patents and On Vitamin C ALA 1,156
Bystolic’s generic Nebivolol – Positive Effect on circulating Endothelial Progenitor Cells Endogenous Augmentation ALA 1,154
The History of Hematology and Related Sciences LHB 1,151
Heroes in Medical Research: Barnett Rosenberg and the Discovery of Cisplatin SJW 1,146
Overview of New Strategy for Treatment of T2DM: SGLT2 Inhibiting Oral Antidiabetic Agents AV 1,143
Imatinib (Gleevec) May Help Treat Aggressive Lymphoma: Chronic Lymphocytic Leukemia (CLL) ALA 1,140
Issues in Personalized Medicine in Cancer: Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing SJW 1,137
New England Compounding Center: A Family Business AK 1,120
EpCAM [7.4] LHB 1,113
Amyloidosis with Cardiomyopathy LHB 1,110
Can Mobile Health Apps Improve Oral-Chemotherapy Adherence? The Benefit of Gamification. SJW 1,095
Acoustic Neuroma, Neurinoma or Vestibular Schwannoma: Treatment Options ALA 1,089
Treatment of Refractory Hypertension via Percutaneous Renal Denervation ALA 1,088
Proteomics – The Pathway to Understanding and Decision-making in Medicine LHB 1,085
Low Bioavailability of Nitric Oxide due to Misbalance in Cell Free Hemoglobin in Sickle Cell Disease – A Computational Model AS 1,085
Pancreatic Cancer: Genetics, Genomics and Immunotherapy TB 1,083
A NEW ERA OF GENETIC MANIPULATION   DS 1,075
Targeting Mitochondrial-bound Hexokinase for Cancer Therapy ZR 1,074
Normal and Anomalous Coronary Arteries: Dual Source CT in Cardiothoracic Imaging JDP

ALA

1,062
Transdermal drug delivery (TDD) system and nanotechnology: Part II TB 1,057
Lung Cancer (NSCLC), drug administration and nanotechnology TB 1,046
Pharma World: The Pharmaceutical Industry in Southeast Asia – Pharma CPhI 20-22 March, 2013, Jakarta International Expo, Jakarta, Indonesia ALA 1,045
Nitric Oxide and Sepsis, Hemodynamic Collapse, and the Search for Therapeutic Options LHB 1,044
Targeted delivery of therapeutics to bone and connective tissues: current status and challenges- Part I AV 1,044
Press Coverage ALA 1,036
Carbohydrate Metabolism LHB 1,036
Open Abdominal Aortic Aneurysm (AAA) repair (OAR) vs. Endovascular AAA Repair (EVAR) in Chronic Kidney Disease Patients – Comparison of Surgery Outcomes LHB

ALA

1,032
In focus: Melanoma Genetics RS 1,018
Cholesteryl Ester Transfer Protein (CETP) Inhibitor: Potential of Anacetrapib to treat Atherosclerosis and CAD ALA 1,015
Medical Devices Start Ups in Israel: Venture Capital Sourced Locally – Rainbow Medical (GlenRock) & AccelMed (Arkin Holdings) ALA 1,007
The Development of siRNA-Based Therapies for Cancer ZR 1,003

Other related articles published in this Open Access Online Scientific Journal include the following:

FIVE years of e-Scientific Publishing @pharmaceuticalintellicence.com, Top Articles by Author and by e-Views >1,000, 4/27/2012 to 1/29/2018

https://pharmaceuticalintelligence.com/2017/04/28/five-years-of-e-scientific-publishing-pharmaceuticalintellicence-com-top-articles-by-author-and-by-e-views-1000-4272012-to-4272017/

Read Full Post »


37th Annual J.P. Morgan HEALTHCARE CONFERENCE: News at #JPM2019 for Jan. 10, 2019: Deals and Announcements

Reporter: Stephen J. Williams, Ph.D.

From Biospace.com

 

JP Morgan Healthcare Conference Update: Sage, Mersana, Shutdown Woes and Babies

Speaker presenting to audience at a conference

With the J.P. Morgan Healthcare Conference winding down, companies remain busy striking deals and informing investors about pipeline advances. BioSpace snagged some of the interesting news bits to come out of the conference from Wednesday.

SAGE Therapeutics – Following a positive Phase III report that its postpartum depression treatment candidate SAGE-217 hit the mark in its late-stage clinical trial, Sage Therapeutics is eying the potential to have multiple treatment options available for patients. At the start of J.P. Morgan, Sage said that patients treated with SAGE-217 had a statistically significant improvement of 17.8 points in the Hamilton Rating Scale for Depression, compared to 13.6 for placebo. The company plans to seek approval for SAGE-2017, but before that, the FDA is expected to make a decision on Zulresso in March. Zulresso already passed muster from advisory committees in November, and if approved, would be the first drug specifically for postpartum depression. In an interview with the Business Journal, Chief Business Officer Mike Cloonan said the company believes there is room in the market for both medications, particularly since the medications address different patient populations.

 

Mersana Therapeutics – After a breakup with Takeda Pharmaceutical and the shelving of its lead product, Cambridge, Mass.-based Mersana is making a new path. Even though a partial clinical hold was lifted following the death of a patient the company opted to shelve development of XMT-1522. During a presentation at JPM, CEO Anna Protopapas noted that many other companies are developing therapies that target the HER2 protein, which led to the decision, according to the Boston Business Journal. Protopapas said the HER2 space is highly competitive and now the company will focus on its other asset, XMT-1536, an ADC targeting NaPi2b, an antigen highly expressed in the majority of non-squamous NSCLC and epithelial ovarian cancer. XMT-1536 is currently in Phase 1 clinical trials for NaPi2b-expressing cancers, including ovarian cancer, non-small cell lung cancer and other cancers. Data on XMT-1536 is expected in the first half of 2019.

Novavax – During a JPM presentation, Stan Erck, CEO of Novavax, pointed to the company’s RSV vaccine, which is in late-stage development. The vaccine is being developed for the mother, in order to protect an infant. The mother transfers the antibodies to the infant, which will provide the baby with protection from RSV in its first six months. Erck called the program historic. He said the Phase III program is in its fourth year and the company has vaccinated 4,636 women. He said they are tracking the women and the babies. Researchers call the mothers every week through the first six months of the baby’s life to acquire data. Erck said the company anticipates announcing trial data this quarter. If approved, Erck said the market for the vaccine could be a significant revenue driver.

“You have 3.9 million birth cohorts and we expect 80 percent to 90 percent of those mothers to be vaccinated as a pediatric vaccine and in the U.S. the market rate is somewhere between $750 million and a $1 billion and then double that for worldwide market. So it’s a large market and we will be first to market in this,” Erck said, according to a transcript of the presentation.

Denali Therapeutics – Denali forged a collaboration with Germany-based SIRION Biotech to develop gene therapies for central nervous disorders. The two companies plan to develop adeno-associated virus (AAV) vectors to enable therapeutics to cross the blood-brain barrier for clinical applications in neurodegenerative diseases including Parkinson’s, Alzheimer’s disease, ALS and certain other diseases of the CNS.

AstraZeneca – Pharma giant AstraZeneca reported that in 2019 net prices on average across the portfolio will decrease versus 2018. With a backdrop of intense public and government scrutiny over pricing, Market Access head Rick Suarez said the company is increasing its pricing transparency. Additionally, he said the company is looking at new ways to price drugs, such as value-based reimbursement agreements with payers, Pink Sheet reported.

Amarin Corporation – As the company eyes a potential label expansion approval for its cardiovascular disease treatment Vascepa, Amarin Corporation has been proactively hiring hundreds of sales reps. In the fourth quarter, the company hired 265 new sales reps, giving the company a sales team of more than 400, CEO John Thero said. Thero noted that is a label expansion is granted by the FDA, “revenues will increase at least 50 percent over what we did in the prior year, which would give us revenues of approximate $350 million in 2019.”

Government Woes – As the partial government shutdown in the United States continues into its third week, biotech leaders at JPM raised concern as the FDA’s carryover funds are dwindling. With no new funding coming in, reviews of New Drug Applications won’t be able to continue past February, Pink Sheet said. While reviews are currently ongoing, no New Drug Applications are being accepted by the FDA at this time. With the halt of NDA applications, that has also caused some companies to delay plans for an initial public offering. It’s hard to raise potential investor excitement without the regulatory support of a potential drug approval. During a panel discussion, Jonathan Leff, a partner at Deerfield Management, noted that the ongoing government shutdown is a reminder of how “overwhelmingly dependent the whole industry of biotech and drug development is on government,” Pink Sheet said.

Other posts on the JP Morgan 2019 Healthcare Conference on this Open Access Journal include:

#JPM19 Conference: Lilly Announces Agreement To Acquire Loxo Oncology

36th Annual J.P. Morgan HEALTHCARE CONFERENCE January 8 – 11, 2018

37th Annual J.P. Morgan HEALTHCARE CONFERENCE: #JPM2019 for Jan. 8, 2019; Opening Videos, Novartis expands Cell Therapies, January 7 – 10, 2019, Westin St. Francis Hotel | San Francisco, California

37th Annual J.P. Morgan HEALTHCARE CONFERENCE: News at #JPM2019 for Jan. 8, 2019: Deals and Announcements

 

Read Full Post »


Open Access e-Scientific Publishing: Elected among 2018 Nature’s 10 Top Influencers – ROBERT-JAN SMITS: A bureaucrat launched a drive to transform science publishing

Curator: Aviva Lev-Ari, PhD, RN,

Editor-in-Chief, https://pharmaceuticalintelligence.com/

UPDATED by 1/15/2019

Entire editorial board resigns over open access

The editorial board of an influential scientometrics journal — the Journal of Informetrics — has resigned and launched a competing free-to-read journal. The board wanted Elsevier to offer free access to detailed citation data, among other things. “Elsevier needs to be able to continue investing in ways that add value to the research process, which it cannot do if it gives this value away for free,” said the publisher. The former editors have launched a competing free-to-read journal called Quantitative Science Studies.

Nature | 4 min read

2018 Nature’s 10

  • Yuan Cao, Graphene wrangler
  • Viviane Slon, Humanity’s historian
  • He Jiankui, CRISPR rogue
  • Jess Wade, Diversity champion
  • Valérie Masson-Delmotte, Earth monitor
  • Anthony Brown, Star mapper
  • Bee Yin Yeo, Force for the environment
  • Barbara Rae-Venter, DNA detective
  • Robert-Jan Smits, Open-access leader
  • Makoto Yoshikawa, Asteroid hunter

Ones to watch 2019

About Nature’s 10

About the Nature’s 10 image

 

ROBERT-JAN SMITS: Open-access leader: A bureaucrat launched a drive to transform science publishing.

BY HOLLY ELSE

Credit: Artur Eranosian/European Commission

The architect of this year’s bold push to get rid of paywalls in science publishing says he got his ideas from an unlikely source: the publishers themselves.

In March, Robert-Jan Smits was tasked by the European Union’s research commissioner, Carlos Moedas, with a special one-year mission: to get more research papers published outside journal paywalls, and fast. A veteran science-policy bureaucrat, Smits decided to go to the source: he asked big publishers how he could do it. They told him that if the organizations that pay for research insisted the findings had to be published openly, journals would have to adapt.

So that’s what Smits set out to persuade research funders to do — in a plan launched in September that has sent shock waves through science publishing.

Smits has spent decades pulling the science-policy strings at the European Commission, and, until his current assignment, had served eight years as the director-general of research. He was ideally connected to begin rallying Europe’s agencies with the idea, dubbed Plan S for ‘science, speed, solution, shock’, as he puts it. As Nature went to press, 16 funders had signed the plan; they require that the results of work they support be made freely available at the time of publication, starting in 2020.

Publishers have been dictating how research is published for decades, Smits says. “Now it is the funders calling the shots, and we will do things differently.”

It’s too early to know what the ultimate impact of Plan S on research publishing will be. Its details are open for consultation, and much might depend on how many other funders adopt the idea — but it will at least improve access to research, says Peter Suber, director of the Harvard Open Access Project and the Harvard Office for Scholarly Communication in Cambridge, Massachusetts. Smits has been overwhelmed with messages of support. But the initiative has also met with resistance: several publishers have said it could put them out of business, and some researchers have said that they don’t want their choice of where to publish to be restricted.

Smits is no stranger to disrupting the status quo in European science. In 2007, he was instrumental in setting up the excellence-focused European Research Council (ERC) funding agency — when, he says, very few member states wanted it. “We had to go country by country to convince people that we needed it,” he says.

Those who have worked with Smits are not surprised by his ability to get consensus on controversial policies. “Robert-Jan has a fantastic memory, of people, events, documents, policies. His networking capacity is spectacular,” says Helga Nowotny, a former president of the ERC.

Smits’ short tenure as open-access tsar is almost over. Next year, he will leave to become chair of the Eindhoven University of Technology in his native Netherlands. “It’s time for me to leave the commission at what I consider my height,” he says.

SOURCE

https://www.nature.com/immersive/d41586-018-07683-5/index.html?utm_source=Nature+Briefing&utm_campaign=2c80f8d674-briefing-dy-20181218&utm_medium=email&utm_term=0_c9dfd39373-2c80f8d674-43323101

Other Related articles published in this Open Access Online Journal include the following:

University of California accounts for nearly 10% of all published research in the United States. It’s also a significant partner of Elsevier, which publishes about 18% of all UC output and collects more than 25% of the university’s $40-million overall subscription budget.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/12/09/university-of-california-accounts-for-nearly-10-of-all-published-research-in-the-united-states-its-also-a-significant-partner-of-elsevier-which-publishes-about-18-of-all-uc-o/

‘Plan S’ of Eleven research funders in Europe will make all scientific works free to read as soon as they are published – New policy if adopted could determine the Future of Global Journal Subscription as doomed

 

 

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/10/01/plan-s-of-eleven-research-funders-in-europe-will-make-all-scientific-works-free-to-read-as-soon-as-they-are-published-new-policy-if-adopted-could-determine-the-future-of-global-jou/

 

https://pharmaceuticalintelligence.com/open-access-scientific-journal/

Three Genres in e-Scientific Publishing AND Three Scientists’ Dilemmas

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/06/28/three-genres-in-e-scientific-publishing-and-three-scientists-dilemmas/

e-Scientific Publishing: The Competitive Advantage of a Powerhouse for Curation of Scientific Findings and Methodology Development for e-Scientific Publishing – LPBI Group, A Case in Point

Author and Editor-in-Chief: Aviva Lev-Ari, PhD RN

https://pharmaceuticalintelligence.com/2017/06/20/e-scientific-publishing-the-competitive-advantage-of-a-powerhouse-for-curation-of-scientific-findings-and-methodology-development-for-e-scientific-publishing-lpbi-group-a-case-in-point/

Innovations in electronic Scientific Publishing (eSP): Case Studies in Marketing eContent, Curation Methodology, Categories of Research Functions, Interdisciplinary conceptual innovations by Cross Section of Categories, Exposure to Frontiers of Science by Real Time Press coverage of Scientific Conferences

Editor-in-Chief http://pharmaceuticalintelligence.comAviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/05/06/case-studies-of-innovations-in-electronic-scientific-publishing-esp-marketing-econtent-curation-methodology-categories-of-research-functions-interdisciplinary-conceptual-innovations-by-cross-sec/

FIVE years of e-Scientific Publishing @pharmaceuticalintellicence.com, Top Articles by Author and by e-Views >1,000, 4/27/2012 to 1/29/2018

Editor-in-Chief: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/04/28/five-years-of-e-scientific-publishing-pharmaceuticalintellicence-com-top-articles-by-author-and-by-e-views-1000-4272012-to-4272017/

 

e-Recognition via Friction-free Collaboration over the Internet: “Open Access to Curation of Scientific Research”

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2013/03/17/e-recognition-via-friction-free-collaboration-over-the-internet-open-access-to-curation-of-scientific-research/

Read Full Post »

Older Posts »