Cause of Alzheimer’s Discovered: protein SIRT6 role in DNA repair process – low levels enable DNA damage accumulation | Leaders in Pharmaceutical Business Intelligence (LPBI) Group

« Ultra-Pure Melatonin Product Helps Maintain Sleep for Up to 7 Hours

Cause of Alzheimer’s Discovered: protein SIRT6 role in DNA repair process – low levels enable DNA damage accumulation

June 15, 2017 by 2012pharmaceutical

Cause of Alzheimer’s Discovered: protein SIRT6 role in DNA repair process – low levels enable DNA damage accumulation

Reporter: Aviva Lev-Ari, PhD, RN

According to lead author Dr. Deborah Toiber of the BGU Department of Life Sciences, “If a decrease in SIRT6 and lack of DNA repair is the beginning of the chain that ends in neurodegenerative diseases in seniors, then we should be focusing our research on how to maintain production of SIRT6 and avoid the DNA damage that leads to these diseases.”

SOURCE

https://toiber.wixsite.com/toiber-lab/about-the-lab

Publications

Publications PubMed

Google Scholar

Neuroprotective functions for the histone deacetylase SIRT6

Shai Kaluski Miguel Portillo, Antoine Besnard, Daniel Stein, Monica Einav, Lei Zhong, Uwe Ueberham, Thomas Arendt, Raul Mostoslavsky, Amar Sahay, Debra Toiber

Cell Reports 2017 Mar 28;18(13):3052-3062

Long noncoding RNA: noncoding and not coded.

Toiber D, Leprivier G, Rotblat B.

Cell Death Discov. 2017 Jan 9;3:16104. doi: 10.1038/cddiscovery.2016.104.

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D’Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R.

Mol Cell. 2013 Aug 22;51(4):454-68. doi: 10.1016/j.molcel.2013.06.018.

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.

Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047.

Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.

Cohen-Kfir E, Artsi H, Levin A, Abramowitz E, Bajayo A, Gurt I, Zhong L, D’Urso A, Toiber D, Mostoslavsky R, Dresner-Pollak R.

Endocrinology. 2011 Dec;152(12):4514-24. doi: 10.1210/en.2011-1128.

Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance.

Toiber D, Sebastian C, Mostoslavsky R.

Handb Exp Pharmacol. 2011; 206:189-224. doi: 10.1007/978-3-642-21631-2_9.

A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.

Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM.

Mol Cell. 2011 Jun 10;42(5):689-99. doi: 10.1016/j.molcel.2011.04.020.

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

Toiber D, Azkona G, Ben-Ari S, Torán N, Soreq H, Dierssen M.

Neurobiol Dis. 2010 Oct;40(1):348-59. doi: 10.1016/j.nbd.2010.06.011.

Acetylcholinesterase variants in Alzheimer’s disease: from neuroprotection to programmed cell death.

Greenberg DS, Toiber D, Berson A, Soreq H.

Neurodegener Dis. 2010;7(1-3):60-3. doi: 10.1159/000285507.

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Zhong L, D’Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.

Cell. 2010 Jan 22;140(2):280-93. doi: 10.1016/j.cell.2009.12.041.

Pro-apoptotic protein-protein interactions of the extended N-AChE terminus.

Toiber D, Greenberg DS, Soreq H.

J Neural Transm 2009 Nov;116(11):1435-42. doi: 10.1007/s00702-009-0249-2.

N-acetylcholinesterase-induced apoptosis in Alzheimer’s disease.

Toiber D, Berson A, Greenberg D, Melamed-Book N, Diamant S, Soreq H.

PLoS One. 2008 Sep 1;3(9):e3108. doi: 10.1371/journal.pone.0003108.

A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress.

Kehat R, Zemel E, Cuenca N, Evron T, Toiber D, Loewenstein A, Soreq H, Perlman I.

Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1290-7.

Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants.

Ben-Ari S*, Toiber D*, Sas AS, Soreq H, Ben-Shaul Y.