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Tweets and Retweets @ COVID-19 and AI: A Virtual Conference – Human-Centered Artificial Intelligence Institute, Stanford University, 4/1/2020, 9AM PST – 3:30PM PST @StanfordHAI  BY @pharma_BI and @AVIVA1950

COVID-19 and AI: A Virtual Conference – Human-Centered Artificial Intelligence Institute, Stanford University, 4/1/2020, 9AM PST – 3:30PM PST @StanfordHAI @pharma_BI @AVIVA1950

Real Time coverage: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2020/04/01/covid-19-and-ai-a-virtual-conference-human-centered-artificial-intelligence-stanford-university-4-1-2020-9am-pst-330pm-pst/

Aviva Lev-Ari
@AVIVA1950

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@StanfordHAI @pharma_BI @AVIVA1950 pharmaceuticalintelligence.com/coronavirus-po Fei-Fei Li AGE Fatality rate and infection rate of the aged Interaction between Acute Infection and Chronic Disease Safety of home – AI sensors at home Sensors data on secure systems clinically data recognized detection

Aviva Lev-Ari
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@StanfordHAI @pharma_BI @AVIVA1950 pharmaceuticalintelligence.com/coronavirus-po Identifying COVID-19 Vaccine Candidates with ML Binbin Chen, MD and Ph.D. Student, Department of Genetics, Stanford University Immunogenic component of vaccine for COVID-19 spike protein bind epitome

Aviva Lev-Ari
@AVIVA1950

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@StanfordHAI @pharma_BI @AVIVA1950 pharmaceuticalintelligence.com/coronavirus-po Repurposing Existing Drugs to Fight COVID-19 Stefano Rensi #NLP Mine the literature for Proteins: Genomes genes proteins Biophysics #docking simulations for energy of 18 molecules as inhibitors  Selection of candidate

Aviva Lev-Ari
@AVIVA1950

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@StanfordHAI @pharma_BI @AVIVA1950 pharmaceuticalintelligence.com/coronavirus-po #ML can be helpful in critical care navigate complexity by automating processes vaccine mutations in the spike protein binding ACE2

Aviva Lev-Ari
@AVIVA1950

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@StanfordHAI @pharma_BI @AVIVA1950 pharmaceuticalintelligence.com/coronavirus-po Mining article on sample size domain ares expert add to the challenges vs CS expertise alone

Aviva Lev-Ari
@AVIVA1950

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@StanfordHAI @pharma_BI @AVIVA1950 pharmaceuticalintelligence.com/coronavirus-po #Virtual #informed #consent of #patient to accelerate ##clinical #trials

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Xavier Amatriain Lack accessibility to health care systems HC Accessibility and Scalability AI based HC IT System PDA – Personalized Diagnostics Assessment – for self reporting AI Automations + Physicians home testing

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Tina White, Ph.D. Candidate, Department of Mechanical Engineering, Stanford University China death toll >1000 China launched App to monitor quarantine early 1/2020 GPS based new App for contact tracing regulation on data

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po John Brownstein Late December 2019 collecting dat a HealthMap – public domain Baidu – has movement information connected with cases Temperature Data published Buoy data base customized to collect MA data on Temperature

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Jason Wang commend center in December 2019 All flight entering the country – Level 3 alert country: China Huhan, Hubei Quarantine all arriving from Level 3 alert country National STOKE PILES Activated x5 mask production

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

#AI

pharmaceuticalintelligence.com/coronavirus-po Jason Wang Since 2003 Taiwan is preparing for a Pangemic JAMA paper on the topic is beebn reported  Location of patient Taiwan National Epidemic Center 100 persons 24×7 in the Command Center Taiwan activated

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Michele Barry,TRACE together – Bluetooth tool on distance among people CHINA – contact racing surveillence scanning temp strict social distancing Hong Kong – tracing bracelets for quarantine Street locations of infected

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Michele Barry 5Million people travel out of Huhan Singapore – Free testing 1st country Temp testing stay at home, text phone from Authorities, show picture they are in quarantine for 5 days if negative  TRACE together

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Seema Yasmin March 7, 2020 Italy news quarantine of 16 million lockdown large movement of people moving out of lockeddown areas, this movement based on information lead to spread of the viral spread

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Nigam Shah,  Operational Planning – Utilization – Resource planning Clinical – who to test Research Questions – ACE2 receptors

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

Aviva Lev-Ari
@AVIVA1950

I am at

TODAY

for our Portal @

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com
3

Aviva Lev-Ari
@AVIVA1950

covering in real time Stanford HAI – COVID-19 and AI: A Virtual Conference youtu.be/z4105Exe23Q via

Stanford HAI – COVID-19 and AI: A Virtual Conference
COVID-19 and AI: A Virtual Conference will address a developing public health crisis. Sponsored by the Stanford Institute for Human-Centered Artificial Intel…
youtube.com

Aviva Lev-Ari
@AVIVA1950

I am at

TODAY

for our Portal @

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com
3

Aviva Lev-Ari
@AVIVA1950

covering in real time Stanford HAI – COVID-19 and AI: A Virtual Conference youtu.be/z4105Exe23Q via

Stanford HAI – COVID-19 and AI: A Virtual Conference
COVID-19 and AI: A Virtual Conference will address a developing public health crisis. Sponsored by the Stanford Institute for Human-Centered Artificial Intel…
youtube.com

Aviva Lev-Ari
@AVIVA1950

I am at

TODAY

for our Portal @

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com
3

Aviva Lev-Ari
@AVIVA1950

covering in real time Stanford HAI – COVID-19 and AI: A Virtual Conference youtu.be/z4105Exe23Q via

Stanford HAI – COVID-19 and AI: A Virtual Conference
COVID-19 and AI: A Virtual Conference will address a developing public health crisis. Sponsored by the Stanford Institute for Human-Centered Artificial Intel…
youtube.com
1

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Stanford Institute for Human-Centered Artificial Intelligence (HAI) Conference on COVID-19 and AI: A Virtual Conference on April 1, 2020 beginning at 9:00am (PDT). event covered in real time

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

 

Stanford HAI
@StanfordHAI

Vaccines are one of the most powerful tools to curb a pandemic and prevent its recurrence,

says. He discusses how AI tools built upon immunology knowledge and data can increase the chances of finding an effective vaccine. stanford.io/3aBidgh

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1
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Aviva Lev-Ari
@AVIVA1950

I am at

TODAY

for our Portal @

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com
2

Aviva Lev-Ari
@AVIVA1950

covering in real time Stanford HAI – COVID-19 and AI: A Virtual Conference youtu.be/z4105Exe23Q via

Stanford HAI – COVID-19 and AI: A Virtual Conference
COVID-19 and AI: A Virtual Conference will address a developing public health crisis. Sponsored by the Stanford Institute for Human-Centered Artificial Intel…
youtube.com
1

Aviva Lev-Ari
@AVIVA1950

Aviva Lev-Ari
@AVIVA1950

I am at

TODAY

for our Portal @

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com
2

Aviva Lev-Ari
@AVIVA1950

covering in real time Stanford HAI – COVID-19 and AI: A Virtual Conference youtu.be/z4105Exe23Q via

Stanford HAI – COVID-19 and AI: A Virtual Conference
COVID-19 and AI: A Virtual Conference will address a developing public health crisis. Sponsored by the Stanford Institute for Human-Centered Artificial Intel…
youtube.com
1

Aviva Lev-Ari
@AVIVA1950

pharmaceuticalintelligence.com/coronavirus-po Stanford Institute for Human-Centered Artificial Intelligence (HAI) Conference on COVID-19 and AI: A Virtual Conference on April 1, 2020 beginning at 9:00am (PDT). event covered in real time

Coronavirus Portal
CORONAVIRUS PORTAL @LPBI   Launched on 3/14/2020 OPEN TO GUEST AUTHORS on Seven Selected Topics & Lead Curator for Contact:   Development of Medical Counter-measures for 2019-nCoV, Co…
pharmaceuticalintelligence.com

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Curation of Resources for High Risk People  to COVID-19 Infection :Guidances for Transplant Patients

Curator: Stephen J. Williams, PhD

 

From the American Society of Transplantation

Source: https://www.myast.org/information-transplant-professionals-and-community-members-regarding-2019-novel-coronavirus

INFORMATION FOR TRANSPLANT PROFESSIONALS AND COMMUNITY MEMBERS REGARDING 2019 NOVEL CORONAVIRUS

The recent outbreak of a novel coronavirus (COVID-19) in Wuhan, Hubei Province, China and the finding of infection in many other countries including the United States has led to questions among transplant programs, Organ Procurement Organizations (OPOs) and patients. The Organ Procurement and Transplantation Network (OPTN) strives to provide up-to-date information to answer these questions and to provide guidance as needed. Accordingly, the OPTN Ad Hoc Donor Transmission Advisory Committee (DTAC), American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS), after careful review of information available from the Centers for Disease Control and Prevention (CDC), offers information to transplant programs and OPOs in light of these concerns. Please visit the OPTN  website for more information.

The American Society of Transplantation recently conducted a Town Hall on guidances for transplant patients with regard to the COVID-19 pandemic.  A video recording of the Town Hall is given below

 

 

Description of the Town Hall by the AST: A number of transplant organizations from around the world have partnered to develop this educational webinar for the organ donation and transplantation communities. Our goal is to share experiences to date and respond to your questions about the impact of COVID-19 on organ donation and transplantation.

 

This webinar was recorded on March 23, 2020.

 

Resource Handout: https://www.myast.org/sites/default/f…

AST COVID-19 Page: https://www.myast.org/covid-19-inform…

 

The American Society of Transplantation has other up to date resources on their webpage at https://www.myast.org/covid-19-information#

AST Resources For Transplant Professionals 

Information for Transplant Professionals (Updated 3/31/20)

Medication Access and Drug Shortage Concerns During the COVID-19 Pandemic: Frequently Asked Questions (posted 3/31/20)

AST Resources For Transplant Recipients and Candidates 

Information for Transplant Recipients and Candidates (Updated 3/30/20)

Other Resources like videos and further articles

Frequently Asked Questions can be found here https://www.myast.org/coronavirus-disease-2019-covid-19-frequently-asked-questions-transplant-candidates-and-recipients

Mark Spigler from the American Kidney Fund listed some tips specifically for kidney transplant recipients. In his blog

Coronavirus, COVID-19 and kidney patients: what you need to know he wrote:

Because transplant recipients take immunosuppressive drugs, they are at higher risk of infection from viruses such as cold or flu. To limit the possibility of being exposed to the coronavirus that causes COVID-19, transplant patients should follow the CDC’s tips to avoid catching or spreading germs, and contact their health care provider if they develop cold or flu-like symptoms. By being informed and taking your own personal precautions, you can help reduce your risk of coming in contact with the coronavirus that causes COVID-19. You can find more information and resources for kidney patients by visiting our special coronavirus webpage at KidneyFund.org/coronavirus. We’ll update the page with important information for kidney patients and their caregivers as the coronavirus crisis continues to unfold.

Resources from the National Kidney Foundation

Source: https://www.kidney.org/coronavirus/transplant-coronavirus

Coronavirus and Kidney Transplants (please click on the links below)

For more information concerning various issues on COVID-19 please see our Coronavirus Portal at:

https://pharmaceuticalintelligence.com/coronavirus-portal/

 

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Stanford Institute for Human-Centered Artificial Intelligence (HAI) Conference on COVID-19 and AI: A Virtual Conference on April 1, 2020 beginning at 9:00am (PDT).

COVID-19 and AI: A Virtual Conference – Human-Centered Artificial Intelligence Institute, Stanford University, 4/1/2020, 9AM PST – 3:30PM PST

https://hai.stanford.edu/events/covid-19-and-ai-virtual-conference/agenda?mkt_tok=eyJpIjoiWVRobFpXTmhZV0ZsWVdFeiIsInQiOiJvejBtSFwvV044bEtBeUJuMlEzSEJOdDJ5K2NFMVwvMFwvemZxb1N6cEc5RU9NOTZCMGt0eEJTYzNtbWhWend4eTFhRnl5a2dSbm44T0JoZ3hOOTNMTk54eUU1UzFwNTBcLzhTT2VRbFwvdThpVzlXQlwvc2k5QWswSVVraGl0VXlSa3ZSRCJ9

@StanfordHAI

@pharma_BI

@AVIVA1950

Real Time coverage: Aviva Lev-Ari, PhD, RN

Agenda

Wednesday, April 1, 2020

*Speakers and session titles are subject to change

*All times are in PDT

Time Session Information
9:00-9:20

Welcome and Preview

John Etchemendy, Denning Family Co-Director, Stanford Institute for Human-Centered Artificial Intelligence; Provost Emeritus, and Patrick Suppes Family Professor in the School of Humanities and Sciences, Stanford University

Fei-Fei Li, Denning Family Co-Director, Stanford Institute for Human-Centered Artificial Intelligence; Sequoia Professor of Computer Science, Stanford University
Russ Altman, Kenneth Fong Professor and Professor of Bioengineering, of Genetics, of Medicine (General Medical Discipline), of Biomedical Data Science, and, by courtesy, of Computer Science, Stanford University; Associate Director, Stanford Institute for Human-Centered Artificial Intelligence
Michele Elam, William Robertson Coe Professor of Humanities Department of English Center for Comparative Studies in Race & Ethnicity, Stanford University; Associate Director, Stanford Institute for Human-Centered Artificial Intelligence
Rob Reich, Professor of Political Science, Stanford University; Associate Director, Stanford Institute for Human-Centered Artificial Intelligence
9:20-10:30

Session I: Landscape and Framing

Talk Titles & Speakers

Challenges Responding to COVID-19: Perspectives from a Physician and Policy Maker
Congressman Ami Bera, California’s 7th Congressional District in the U.S. House of Representatives

  • past pandemics: SARS, MERS, EBOLA, ZIKA – preparedness during Obama, disband 12/2018, 11/2019 and 1/2020 reports from China on COVID-19 came along,U.S. House of Representatives
    • 2/2020 – Ban of Travel to China, preparedness was needed, UC, Davis at the front
    • CDC pushing own test cause lost of time – changing criteria social distancing
    • Sacramento County – Hospitals prepared and ramped up testing
    • FL and TX are lagging on ramped up testing and social distancing policy
    • Big data and AI in congress – as next steps
    • Korea, Singapore, China – Serological testing represent diffusion in the community and immunity in communities vs Diagnostics Testing (virus present or no)
    • John Hopkins Data Source – North hemisphere vs South hemisphere

An Academic Medical Center’s Data Science Response to a Pandemic
Nigam Shah, Associate Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science, Stanford University

  • Operational Planning – Utilization – Resource planning
  • Clinical – who to test
  • Research Questions – ACE2 receptors
  • Epidemic simulations – when get out from lockdown
  • Next five Days – Predictions for 5 days using simulations: Growth rate & Disease burden
  • County like ONE huge hospital – rolled up to Regions
  • Relations from Social distancing and Hospital planning
  • Population studies: Geography information in Santa Clara county – Stanford Covid-19 Report
  • Administration to legally command Hotels and Companies to retool change temporary sovereignty

Issues in Responsible Reporting of COVID-19
Seema Yasmin, Director, Stanford Health Communication Initiative; Clinical Assistant Professor, Medicine, Primary Care and Population Health, Stanford University

  • Epidemic Intelligence Service Officer (Public Health Physician & Journalist on Pandemics and Epidemics
  • March 7, 2020 Italy news quarantine of 16 million lockdown large movement of people moving out of lockeddown areas, this movement based on information lead to spread of the viral spread
  • Hold information, report truth vs false
  • epidemic tool kit for Reporters

Global Best Practices in Controlling the COVID-19 Pandemic
Michele Barry, Professor, Senior Associate Dean, Global Health, Director, Center for Innovation in Global Health; Medicine & Senior Fellow, Woods Institute and at the Freeman Spogli Institute, Stanford University

  • 5Million people travel out of Huhan
  • Singapore – Free testing 1st country Temp testing stay at home, text phone from Authorities, show picture they are in quarantine for 5 days even if negative  – unified Government reporting, Daily messaging, chronicals, social responsibility
  • TRACE together – Bluetooth tool on distance among people  – Information on quarantine – no lockdown
  • CHINA – contact racing surveillance scanning temperature, strict social distancing
  • IRAN – religious interference at later date
  • Hong Kong – tracing bracelets for tracing quarantine Street locations of infected individuals no identity
  • USA – Lack of Testing, State responsibility, CDC nor allowed in a State if not invited
  • Evidence based intervention with AI
  • Masks instructions in the US different than the World: Paper mask vs cloth mask. Airborn infection will be mitigated by Masks of any materials not only paper – people can make to create OWN MADE masks
  • CHINA – Infection avoidance in Healthcare workers: Googles, Mask, Eye shields – lower infection of Health care workers

Panel Discussion and Audience Q&A
Moderator: Rob Reich

10:40-11:40

Session II: Social Impacts & Bio-Security

Talk Titles & Speakers

COVID-19 Infodemic and Crisis Informatics
Kate Starbird, Associate Professor, Human Centered Design & Engineering, University of Washington

  • Human responses to crisis anxiety and unknown
  • quarantine – collective sense making rumors
  • absence of information to make decisions
  • over abandance of information trustworthy vs misinformation vs disinformation
  • vulnerability to information searching seeking and sharing
  • crisis communicators: Trust in Official sources, use science for recommendations
  • Agencies risk loosing trust
  • Politician diminish trust by avoiding truth
  • Social Media took action to avoid misinformation vs disinformation going viral
  • Platforms take actions more at Present than in the Past due to lessons on misinformations
  • stifling and censoring are context dependent
  • misinformation vs disinformation Blames someone else like the US

COVID-19: Misinformation & Disinformation
Renée DiResta, Technical Research Manager, Stanford Internet Observatory

  • China’s English channels State sponsored narrative build Propaganda and control information
  • China White Information ecosystems channels – Attributable diplomats in the English language
  • Google bans China
  • China’s Informational Properties on Google
  • Significant audience on Google by China’s Informational Properties
  • China’s Informational Properties on Google Ads – need to manage perception of China related to narrative COVID-19 Pandemic January 2020, US is one month behind – representation of positive CHina due to response effectiveness vs the government of US positive handling of Infections in babies
  • Doctor discover was arrested was infected and DIED. China’s report was of a HERO doctor not mentioning his detention
  • Removal from SEO causes deemphasizing
  • CDC and WHO – recognitions of institutions as authorities

COVID-19 & Biosecurity
Megan Palmer, Senior Research Scholar, Stanford Center for International Security and Cooperation, Stanford University

  • evolving Security and Cooperation coordination defense
  • Pandemic consequences under estimated
  • Labs causing accidents
  • Avoiding over indexing an event
  • technology for Good vs Ill: AI and Vaccine vs devastating events by viruses
  • Novel viruses in Labs constructed by gene engineering in Switzerland lab posted on the Internet to develop vaccine – use can be negative – reconstruction of pathogens
  • Methods social psychology, gov.t strategy to new
  • AI used in Attribution
  • Infrastructure: Privacy, Sharing, security, surveillance
  • psychology of risk

“Foreign Bodies”: COVID-19 and Xenophobia
Eram Alam, Assistant Professor, History of Medicine, Harvard University

  • “Chinese Virus” Xenophobia
  • 1/27/2020 – 138 years apart 1882 – Chinese body perceived in Trade war between nations in adversarial relations related to security
  • body can be host victim by invading vectors
  • Social distance defined and redefined
  • Archival work and AI
  • Surveillance has material consequences, scientific good
  • Diet of Chinese including eating wild animals stigmatized – social distancing vs Europe and US Travel
  • foreignness of the viral becomes foreignness of the foreign body

Panel Discussion and Audience Q&A
Moderator: Rob Reich

  • Will the coronavirus pandemic change societies for the generations to come
11:50-1:30

Session III: Tracking the Epidemic

Talk Titles & Speakers

Taiwan’s Use of Data Analytics to Control COVID-19
Jason Wang, Director, Center for Policy, Outcomes and Prevention, Stanford University; Associate Professor of Pediatrics, The Lucile Salter Packard Children’s Hospital and of Medicine

  • Since 2003 Taiwan is preparing for a Pangemic, JAMA paper on the topic is beebn reported
  • Location of patient
  • Taiwan – National Epidemic Center 100 persons 24×7 in the Command Center
  • Taiwan activated the commend center in December 2019
  • All flight entering the country – Level 3 alert country: China Huhan, Hubei, another Chinese city
  • Quarantine all arriving from Level 3 alert country
  • National STOKE PILES Activated – production of masks from 2K to 11K per day
  • Logistics, articulate, agile,

Tools for Estimating Unreported Infections of COVID-19
Lucy Li, Infectious Data Scientist, Chan Zuckerberg Biohub

  • Undetected infection using viral genome sequencing
  • DIagnostics testing

Methods for Real Time Mapping of COVID-19 Cases Worldwide
John Brownstein, Professor, Department of Pediatrics, Harvard Medical School

  • Late December 2019 collecting dat a
  • HealthMap – public domain
  • Baidu – has movement information connected with cases
  • Temperature Data published
  • Buoy data base customized to collect MA data on Temperature
  • community mapping data for Health policies with epidemiological data

Epidemiological Forecasting Tools for COVID-19
Ryan Tibshirani, Associate Professor, Department of Statistics and Machine Learning Department, Carnegie Mellon University

  • CDC Forecasting Influenza – National and State level data captured is from Physicians – is one week old
  • Forecast next week
  • Hospitalization predicted
  • Worse case scenario
  • Mechanistic pf the disease differential equation
  • Statistical models are not available
  • DISTRIBUTION SHIFT – represent the prediction of a pandemic
  • Efforts from Influenza used for coronavirus
  • FOrecast distribution not cases or individuals

A Mobile App Intervention to Slow COVID-19 Using Crowdsourced Data
Tina White, Ph.D. Candidate, Department of Mechanical Engineering, Stanford University

  • China death toll >1000 China launched App to monitor quarantine early 1/2020
  • GPS based new App for contact tracing  – regulation on data from GPS 

AI for COVID-19: An Online Virtual Care Approach
Xavier Amatriain, CoFounder and CTO, Curai

  • Lack accessibility to health care systems
  • HC Accessibility and Scalability
  • AI based HC IT System
  • PDA – Personalized Diagnostics Assessment – for self reporting
  • AI Automations + Physicians + embed home testing _ Patients symptoms
  • BERT Language modelnavigate long questionnaire
  • ML + Expert system to create simulated cases to create a DIAGNOSTICS COVID-19 model

Knowledge Technology to Accelerate Open Science in Addressing the COVID-19 Pandemic
Mark Musen, Professor, Department of Medicine (Biomedical Informatics) and of Biomedical Data Science, Stanford University

  • Output of Science and of Data is shared for discoveries by all scientists
  • Data available without a catalogue – no Meta data Data interoperable, reusable,
  • Meta data: GEO at NIH find a specimen
  • NCBI BIOSample – data cleanup needed
  • FAIR Data on COVID-19 – CEDAR – Classes of experiments FORM/Template of data types at CEDAR at Stanford
  • VODAN – CEDAR Data infrastructure VODAN – Viral Ouput Data Network

What We Can Learn From Twitter Analysis About COVID-19
Johannes Eichstaedt, Assistant Professor (Research), Department of Psychology, Stanford University; HAI Junior Fellow

  • Unemployment and life satisfaction
  • Twitter analysis of Clusters of Tweets: Urban Areas: Buying panic
  • Educated counties
  • AGE –
  • Voting
  • Mental illness of loneliness – COVID-19 Adjustment

Panel Discussion and Audience Q&A
Moderator: Russ Altman

1:45- 3:00

Session IV: Treatments & Vaccines

Talk Titles & Speakers

Rapid Analysis of SARS-CoV-2 Genomic Content Using the Functional Genomics Platform
Kristen Beck, Lead Bioinformatician, AI and Cognitive Software, IBM

  • Functional Genomics Platform – in a RDB at IBM
  • COVID-19 Genes, proteins of +200 viruses for comparative analysis
  • Building AI by Training on Variants for anti-viral interactions SNAPS

COVID-19 Machine Learning Challenges
Anthony Goldbloom, Founder and CEO, Kaggle

Three channels @Kaggle

  • NLP Challenge – Coronavirus – all articles subjected to NLP key questions – Automated literature review
  • Forecast cases and fatalities by Cities and Counties by Latitute and Longitude: Different pattern among the entities
  • Data set curation models

Machine Learning Enabled Systems for Delivering Care to Critically Ill Patients 
Ron Li, Clinical Assistant Professor of Medicine, Hospital Medicine and Biomedical Informatics, Stanford University

  • AI used to deliver care to cCOVID19 patients
  • Interdependencies in care delivery using complex systems
  • Understanding the process: Managment Patients with COVID19 – Hospital to ICU intupation caused arosol that endanger Providers – workflow design and clinical data updates the model
  • ML Model validation and usefulness of the model RATE of CHANGE trigger intervention workflow

AI-Assisted Elderly Care for Acute Infection and Chronic Disease
Fei-Fei Li, Denning Family Co-Director, Stanford Institute for Human-Centered Artificial Intelligence; Sequoia Professor of Computer Science, Stanford University

  • AGE Fatality rate and infection rate of the aged
  • Interaction between Acute Infection and Chronic Disease
  • Safety of home – AI sensors at home
  • Sensors data on secure systems clinically data recognized from detection
  • Fever detection – Thermo sensor for detection
  • Mobility – infection behavior
  • Sleep – patterns
  • Diet – fluid intake and pill consumption
  • SMART SENSORS

Identifying COVID-19 Vaccine Candidates with ML
Binbin Chen, MD and Ph.D. Student, Department of Genetics, Stanford University

  • Immunogenic component of vaccine for COVID-19
  • spike protein bind epitome

Repurposing Existing Drugs to Fight COVID-19
Stefano Rensi, Research Engineer, Bioengineering Department, Stanford University

  • NLP – Mine the literature for Proteins: Genomes, genes, proteins
  • Biophysics – docking simulations for the energy of 18 molecules as inhibitors
  • Selection of candidate

Panel Discussion and Audience Q&A

Moderator: Russ Altman

3:00- 3:15

Wrap Up

 

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Glycobiology vs Proteomics: Glycobiologists Prespective in the effort to explain the origin, etiology and potential therapeutics for the Coronavirus Pandemic (COVID-19)

 Curator: Ofer Markman, PhD

 The sugars involved in a viral disease are unique in many ways when compared with the DNA/RNA or the proteins involved: they are almost totally dependent on the infected cells and thus are not affected by the viral mutation rate or by the virus at all. Nevertheless they are affected by the cells, their type and their sugar production mechanisms and in some respect to the production rate by which the virus is replicated in the infected cells. Mutations may have nevertheless major effect not on the structures of the glycans but rather on the existence of the glycosylation site, and thus the glycan at all, but not on its structures.

This may make the gycomolecule a good target for diagnostics as stability in the molecule may mean longer life shelve of diagnostics kits.

Unique sugars are already predicted/found in the virus from certain Chinese origin, in this case an o-linked glycan/s not previously detected.

  • The proximal origin of SARS-CoV-2

Kristian G. AndersenAndrew RambautW. Ian Lipkin, Edward C. Holmes & Robert F. Garry

Nature Medicine (2020)Cite this article

https://www.nature.com/articles/s41591-020-0820-9

  • The covid-19 coronavirus epidemic has a natural origin, scientists say

https://globalhealthnewswire.com/2020/03/17/the-covid-19-coronavirus-epidemic-has-a-natural-origin-scientists-say/

  • Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26

Naveen Vankadari & Jacqueline A. Wilce

https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1739565

Nevertheless, if the virus can infect multiple cells once current cells are not going to be available for any reason those viruses may present other glycans.

Once one starts to treat the infected person via modulation of protein production or by other means the change in the dynamic of protein production vs. protein glycosylation may cause changes in protein glycosyation, including their structures, this is well known to biotechnologists producing glycoproteins in labs and production.

This may either be a problem in understanding the state of disease or an advantage as it may help following response to the treatment and help as a co-treatment diagnostics.

Early Studies include the following:

  • Carbohydrate-based Diagnostics: A New Approach to COVID-19 Testing?

Mar 19, 2020 | Original story from Iceni Diagnostics

https://www.technologynetworks.com/diagnostics/news/carbohydrate-based-diagnostics-a-new-approach-to-covid-19-testing-332313

Glycans may play a role in treatment as well. TAMIFLU a case in point. Tamiflu is directed to the flu enzyme Neuraminidaze that is part of the viral structures. This approach was also explored to develop treatments.

  • Pneumagen Ltd Leverages its Novel Glycan Approach to Target Coronavirus (COVID-19) Infections

March 17, 2020 PR-M03-20-NI-024

https://www.pharmasalmanac.com/articles/pneumagen-ltd-leverages-its-novel-glycan-approach-to-target-coronavirus-covid-19-infections

Glycans do not only effect their own involvement in treatment/diagnostics they also are effecting protein based diagnostics for this see statement by Dr. Michael Mercier of UAH

  • We’re dealing with COVID-19, but what’s a virus in the first place?

23-Mar-2020 8:45 AM EDT, by University of Alabama Huntsville

https://www.newswise.com/articles/we-re-dealing-with-covid-19-but-what-s-a-virus-in-the-first-place

 

Other related articles on this topic published on this topic in this Open Access Online Scientific Journal include the following: 

 

The Relevance of Glycans in the Viral Pathology of COVID-19

Reporter: Ofer Markman, PhD

https://pharmaceuticalintelligence.com/2020/03/23/glycans-in-the-viral-pathology-of-covid-19/

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How is the 3D Printing Community Responding to COVID-19?

Reporter: Irina Robu, PhD

 

As the new pandemic COVID-19 takes over the globe, several countries are implementing travel restrictions, social distancing and work from home policies. Healthcare systems are overloaded and fatigued by this new coronavirus (COVID-19). Since COVID-19 is a respiratory illness, patients require specialist respirators to take over the role of the lungs. These respirators are in short supply, however, along with medical personnel, hospital space and other personal safety equipment required to treat patients.

Professional AM providers, makers and designers in the 3D printing community have started to answer to the global crisis by volunteering their respective skills to ease the pressure on supply chains and governments. The additive manufacturing and 3D printing community has numerous members keen to support during the COVID-19 pandemic.

A hospital in Brescia, Italy with 250 Coronavirus patients lacking breathing machines has recently run out of the respiratory valves needed to connect the patients to the machines. In response to the situation, the CEO of Isinnova, Cristian Fracassi used 3D bioprinting to produce 100 respirator valves in 24 hours, which are currently being put to use in the Brescian hospital.

At the same time, Materialise, has released files for a 3D printed hands-free door handle attachment to lessen Coronavirus transmission via one of the most common mediums. Door handles are exposed to a lot of physical contact over the course of a day, especially in public spaces such as offices and hospitals. The 3D printable add-on allows users to carry out the lever action required to pop open most modern doors using their elbows.

Protolabs, a leading on-demand manufacturer with 3D Printing is using rapid production methods to good use during the current Coronavirus outbreak by producing components for #COVID19 test kits and ventilators. California-based Airwolf3D volunteered their own fleet of 3D printers for the manufacturing of respirator valves and custom medical components. The company is also offering remote technical support for medical staff that would like to know more about 3D printing.

Volkswagen has started a task force that will adapt its car-making capacity and manufacturing facilities to the production of hospital ventilators and medical devices. Using their own 125 industrial 3D printers to tackle the COVID-19 pandemic. At the same time, Volkswagen is donating face masks to healthcare providers and local authorities as part of an agreement made with German Health Minister.

Stratasys has organized its global 3D printing resources to respond to the COVID-19 pandemic by printing full-face shields to provide protection to healthcare workers. The company showed that the strength of 3D bioprinting can be adapted on the fly to address shortages of parts related to shields, masks, and ventilators, among other things.
Doctors, hospital technicians and 3D-printing specialists are also using Google Docs, WhatsApp groups and online databases to trade tips for building, fixing and modifying machines like ventilators to help treat the rising number of patients with COVID-19, the disease caused by the coronavirus.

The efforts come as supply shortages loom in one of the biggest challenges for health care systems around the world.

SOURCE

3D Printing Community responds to COVID-19 and Coronavirus resources

 

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Promise of Synthetic Biology for Covid-19 Vaccine

Reporter: Irina Robu, PhD

 

Researchers and epidemiologists’ race to develop vaccines to block the new Covid-19 pathogen that currently emerged. It’s a rush against the clock, and sometimes the good guys lose: It simply takes too long to identify an effective antigen and produce enough of it to make a dent.

Even as companies rush to advance and test vaccines against the new coronavirus, the Bill and Melinda Gates Foundation and the National Institutes of Health are gambling that scientists can do even better than what’s now in the pipeline. The traditional vaccine-development development is decades old. It involves shipping a sample of the purified virus to a vaccine-development laboratory, developing a nonpathogenic variant of the virus, propagating that new variant in eggs or cultured cells and harvesting them to produce the vaccine.

To develop a coronavirus vaccine, synthetic biologists are currently racing against the clock. It is quite possible that the new Covid-19 virus will become a permanent part of the world’s microbial menagerie rather than being eradicated like the earlier SARS coronavirus, next-gen approaches will be needed to address inadequacies of even the most cutting-edge vaccines: They take years to develop and manufacture, they become obsolete if the virus evolves, and the immune response they produce is often weak.

Neil King, a researcher from University of Washington has been hunting for a coronavirus vaccine since 2017, because he knew that would be another coronavirus epidemic similar to SARS and MERS. His group designed and built nanoparticles out of proteins and attach viral molecules in a repetitive array with the intention of, when the whole thing is packed into a vaccine, it can make people resistant to the new coronavirus. Using computers, they are designing new, self-assembling protein nanoparticles scattered with antigens. If tests in lab animals of the first such nanoparticle vaccine are any indication, it should be more potent than either old-fashioned viral vaccines like those for influenza or the viral antigens on their own (without the nanoparticle).

King and his colleagues (Cell, 2019) developed an experimental vaccine against respiratory syncytial virus (RSV) made of a computer-designed nanoparticle that self-assembles from protein building blocks and is scattered with an engineered version of RSV’s key antigen. When tested in mice and monkeys, it produced 10 times more antibodies than an experimental RSV vaccine based on traditional technology. They believe that with a few tweaks, the nanoparticle can be scattered with molecules from additional coronaviruses such as the original SARS virus, MERS, and a mutated form of the Covid-19-causing virus. As Covid-19 spreads, King and his colleagues are carefully optimistic that it might work.

But even though, Moderna Terapeutics, CureVac and Inovio pharmaceuticals are speeding toward human testing via experimental vaccines that contain synthetic strands of RNA or DNA, the synthetic biology approach has its own advantages. These experimental vaccines contain synthetic strands of RNA or DNA that code for protein molecules on the virus’s surface. Once the vaccine delivers the genetic material into cells, the cells follow the genetic instructions to churn out the viral protein. The knowledge is that the body would perceive that as foreign, generate antibodies to it, and if all goes well thus acquire immunity to the virus.

Researchers already know how to do vaccine development the old-fashioned way, and their manufacturing facilities are set up accordingly. The regulatory approvals required to produce their vaccines are geared to this older technology, as well, and updating those processes and approvals could take considerable time. So even though, researchers are racing against time to find a solution to Covid-19 virus, synthetic biology has such a vast potential.

SOURCE

To develop a coronavirus vaccine, synthetic biologists try to outdo nature

 

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Reporter: Gail S. Thornton, M.A.

The following article is reprinted from the Anchorage Daily News.

https://www.adn.com/alaska-news/2020/03/18/one-of-alaskas-first-confirmed-coronavirus-patients-tells-his-story/

One of Alaska’s first confirmed coronavirus patients tells his story

March 19, 2020

A Ketchikan man who contracted the illness caused by the new coronavirus is speaking out about his experience.

In a social media post and an interview with the Ketchikan Daily News, he described his symptoms, how he was tested and his experience communicating with Alaska public health officials.

As of Wednesday morning, Glenn Brown, the attorney for the Ketchikan Gateway Borough, is one of nine people statewide who have confirmed cases of the virus. Officials have not said any of the people with confirmed cases have been hospitalized.

Brown said in a Facebook post that he was feeling better and was notified by public health officials that he’d tested positive for COVID-19 on Tuesday afternoon.

“I became sick Saturday morning with fever, headache, general achiness and chills,” Brown wrote.

Brown said he has “no idea” how he contracted the illness.

“I interacted with no one in recent weeks who was exhibiting obvious symptoms,” he wrote.

According to a statement Tuesday from the Ketchikan Emergency Operations Center saying one of its employees tested positive for the virus, the employee had a history of travel to the Lower 48. The Ketchikan Emergency Operations Center on Wednesday confirmed Brown is the employee.

The Ketchikan Daily News reported that Brown had recently traveled to Oregon and Juneau before returning to Ketchikan on March 9.

After public health officials told Brown his diagnosis, he said that he went through more than an hour of questions with them, he told the Ketchikan Daily News.

“I used everything from cellphone records to work calendars to debit card bills, to recall everybody that I may have had contact with,” Brown told the Ketchikan Daily News. “I wanted to provide that information to public health, (so) that they could alert those people and really hope to kind of arrest this thing.”

Brown told the paper that public health officials focused on two days before he developed symptoms of the illness. Brown had been “working closely with borough staff and upper management” in those days as part of his job, the paper reported.

“I apologize for causing undue concern for anyone, especially my co-workers at the Borough,” Brown said in the Facebook post.

Ketchikan Gateway Borough employees in direct contact with Brown were instructed to self-quarantine for two weeks, according to the Ketchikan Emergency Operations Center statement.

The statement also said that the borough had hired a service to disinfect the now-closed White Cliff Building, which houses the Ketchikan Borough offices.

According to the Ketchikan Daily News, the last time Brown was at the borough’s White Cliff Building was Friday.

The paper reported that as of Tuesday night, there were no plans to test people who had been in direct contact with Brown.

A public information officer for Ketchikan’s Emergency Operations Center told the Ketchikan Daily News that she understood that to be tested, people would need to have “several” symptoms of the virus.

“I would also ask that you join me and all of Ketchikan to actively minimize community transmission so that we can protect our seniors or other medically vulnerable folks in Ketchikan,” Brown wrote. “I pray that we all make it through this largely unharmed, and together.”

The first person in Alaska to test positive for COVID-19 was an air cargo pilot who arrived at Ted Stevens Anchorage International Airport on March 11, officials announced last week. He went through the airport’s North Terminal, which is separate from the domestic terminal.

Alaska’s chief medical officer, Dr. Anne Zink, said last week the man had self-isolated and was “stable.”

On Monday, officials said two older men in Fairbanks were diagnosed with the illness. Both had recently traveled to the Lower 48, Zink said, but were not traveling together.

In addition to the Anchorage case, the case in Ketchikan and the two in Fairbanks, officials on Tuesday announced that two more people had become sick with the virus — one in Fairbanks and one in Anchorage — bringing the total number of confirmed cases as of Wednesday morning to six.

Zink said that both of those cases were also travel-related. None of the three people who tested positive for COVID-19 on Tuesday were hospitalized, Zink said.

Fairbanks Memorial Hospital released a statement Tuesday saying a woman with a history of recent travel had tested positive for COVID-19.

“She self-isolated prior to testing,” the statement said. “This patient has been notified and is in stable condition and does not require hospitalization.”

A University of Alaska Fairbanks employee was one of the people who had recently tested positive for the virus in Alaska, university officials said Tuesday.

An internal email advised anyone who had used the O’Neill Building, which houses the College of Fisheries and Ocean Sciences, to stay home and monitor themselves for two weeks.

State and local officials have taken a series of steps to stem the spread of COVID-19 in Alaska, including closing schools, calling on hospitals to halt elective surgeries and shutting down dine-in service at all restaurants, bars, breweries, cafes and similar businesses.

About this Author

Morgan Krakow

Morgan Krakow is a general assignment reporter for the Anchorage Daily News. She is a 2019 graduate of the University of Oregon and spent the past summer as a reporting intern on the general assignment desk of The Washington Post. Contact her at mkrakow@adn.com.

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