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Eight Subcellular Pathologies driving Chronic Metabolic Diseases – Methods for Mapping Bioelectronic Adjustable Measurements as potential new Therapeutics: Impact on Pharmaceuticals in Use

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Eight Subcellular Pathologies driving Chronic Metabolic Diseases – Methods for Mapping Bioelectronic Adjustable Measurements as potential new Therapeutics: Impact on Pharmaceuticals in Use

Curators:

• Cardiovascular Expertise – Dr. Justin D. Pearlman, MD, PhD, FACC
• Pharmacology and Oncology Expertise – Dr. Stephen J. Williams, PhD
• Principal Investigator, initiator of the project – Aviva Lev-Ari, PhD, RN

 

THE VOICE of Aviva Lev-Ari, PhD, RN

In this curation we wish to present two breaking through goals:

Goal 1:

Exposition of a new direction of research leading to a more comprehensive understanding of Metabolic Dysfunctional Diseases that are implicated in effecting the emergence of the two leading causes of human mortality in the World in 2023: (a) Cardiovascular Diseases, and (b) Cancer

Goal 2:

Development of Methods for Mapping Bioelectronic Adjustable Measurements as potential new Therapeutics for these eight subcellular causes of chronic metabolic diseases. It is anticipated that it will have a potential impact on the future of Pharmaceuticals to be used, a change from the present time current treatment protocols for Metabolic Dysfunctional Diseases.

According to Dr. Robert Lustig, M.D, an American pediatric endocrinologist. He is Professor emeritus of Pediatrics in the Division of Endocrinology at the University of California, San Francisco, where he specialized in neuroendocrinology and childhood obesity, there are eight subcellular pathologies that drive chronic metabolic diseases.

These eight subcellular pathologies can’t be measured at present time.

In this curation we will attempt to explore methods of measurement for each of these eight pathologies by harnessing the promise of the emerging field known as Bioelectronics.

Unmeasurable eight subcellular pathologies that drive chronic metabolic diseases

1. Glycation
2. Oxidative Stress
3. Mitochondrial dysfunction [beta-oxidation Ac CoA malonyl fatty acid]
4. Insulin resistance/sensitive [more important than BMI], known as a driver to cancer development
5. Membrane instability
6. Inflammation in the gut [mucin layer and tight junctions]
7. Epigenetics/Methylation
8. Autophagy [AMPKbeta1 improvement in health span]

Diseases that are not Diseases: no drugs for them, only diet modification will help

Image source

Robert Lustig, M.D. on the Subcellular Processes That Belie Chronic Disease

https://www.youtube.com/watch?v=Ee_uoxuQo0I

 

Exercise will not undo Unhealthy Diet

Image source

Robert Lustig, M.D. on the Subcellular Processes That Belie Chronic Disease

https://www.youtube.com/watch?v=Ee_uoxuQo0I

 

These eight Subcellular Pathologies driving Chronic Metabolic Diseases are becoming our focus for exploration of the promise of Bioelectronics for two pursuits:

1. Will Bioelectronics be deemed helpful in measurement of each of the eight pathological processes that underlie and that drive the chronic metabolic syndrome(s) and disease(s)?
2. IF we will be able to suggest new measurements to currently unmeasurable health harming processes THEN we will attempt to conceptualize new therapeutic targets and new modalities for therapeutics delivery – WE ARE HOPEFUL

In the Bioelecronics domain we are inspired by the work of the following three research sources:

1. Biological and Biomedical Electrical Engineering (B2E2) at Cornell University, School of Engineering https://www.engineering.cornell.edu/bio-electrical-engineering-0
2. Bioelectronics Group at MIT https://bioelectronics.mit.edu/
3. The work of Michael Levin @Tufts, The Levin Lab

Michael Levin is an American developmental and synthetic biologist at Tufts University, where he is the Vannevar Bush Distinguished Professor. Levin is a director of the Allen Discovery Center at Tufts University and Tufts Center for Regenerative and Developmental Biology. Wikipedia

Born: 1969 (age 54 years), Moscow, Russia

Education: Harvard University (1992–1996), Tufts University (1988–1992)

Affiliation: University of Cape Town

Research interests: Allergy, Immunology, Cross Cultural Communication

Awards: Cozzarelli prize (2020)

Doctoral advisor: Clifford Tabin

Fields: Developmental biology, synthetic biology

SOURCE

https://www.google.com/search?q=Michael+Levin+%40Tufts&oq=Michael+Levin+%40Tufts&aqs=chrome..69i57j69i58.894128314j0j15&sourceid=chrome&ie=UTF-8

Most recent 20 Publications by Michael Levin, PhD

SOURCE

https://facultyprofiles.tufts.edu/michael-levin-1/publications

SCHOLARLY ARTICLE

The nonlinearity of regulation in biological networks

1 Dec 2023npj Systems Biology and Applications9(1)

Co-authorsManicka S, Johnson K, Levin M…1 more

VIEW PDF10.1038/S41540-023-00273-W

3

SCHOLARLY ARTICLE

Toward an ethics of autopoietic technology: Stress, care, and intelligence

1 Sep 2023BioSystems231

Co-authorsWitkowski O, Doctor T, Solomonova E…2 more

VIEW PDF10.1016/J.BIOSYSTEMS.2023.104964

SCHOLARLY ARTICLE

Closing the Loop on Morphogenesis: A Mathematical Model of Morphogenesis by Closed-Loop Reaction-Diffusion

14 Aug 2023Frontiers in Cell and Developmental Biology11:1087650

Co-authorsGrodstein J, McMillen P, Levin M

VIEW PDF10.3389/FCELL.2023.1087650

SCHOLARLY ARTICLE

Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes.

30 Jul 2023Biochim Biophys Acta Gen Subj1867(10):130440

Co-authorsCervera J, Levin M, Mafe S

VIEW MORE INFO10.1016/J.BBAGEN.2023.130440

SCHOLARLY ARTICLE

Regulative development as a model for origin of life and artificial life studies

1 Jul 2023BioSystems229

Co-authorsFields C, Levin M

10.1016/J.BIOSYSTEMS.2023.104927

1

SCHOLARLY ARTICLE

The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left–Right Functional Differences

1 Jul 2023International Journal of Molecular Sciences24(13)

Co-authorsMasuelli S, Real S, McMillen P…3 more

VIEW PDF10.3390/IJMS241311121

SCHOLARLY ARTICLE

Bioelectricidad en agregados multicelulares de células no excitables- modelos biofísicos

Jun 2023Revista Española de Física32(2)

Co-authorsCervera J, Levin M, Mafé S

SCHOLARLY ARTICLE

Bioelectricity: A Multifaceted Discipline, and a Multifaceted Issue!

1 Jun 2023Bioelectricity5(2):75

Co-authorsDjamgoz MBA, Levin M

10.1089/BIOE.2023.0022.EDITORIAL

SCHOLARLY ARTICLE

Control Flow in Active Inference Systems – Part I: Classical and Quantum Formulations of Active Inference

1 Jun 2023IEEE Transactions on Molecular, Biological, and Multi-Scale Communications9(2):235-245

Co-authorsFields C, Fabrocini F, Friston K…4 more

10.1109/TMBMC.2023.3272150

2

SCHOLARLY ARTICLE

Control Flow in Active Inference Systems – Part II: Tensor Networks as General Models of Control Flow

1 Jun 2023IEEE Transactions on Molecular, Biological, and Multi-Scale Communications9(2):246-256

Co-authorsFields C, Fabrocini F, Friston K…4 more

10.1109/TMBMC.2023.3272158

2

SCHOLARLY ARTICLE

Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology

1 Jun 2023Cellular and Molecular Life Sciences80(6)

Co-authorsLevin M

VIEW PDF10.1007/S00018-023-04790-Z

1

SCHOLARLY ARTICLE

Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging

1 Jun 2023Drug Discovery Today28(6)

Co-authorsPio-Lopez L, Levin M

VIEW PDF10.1016/J.DRUDIS.2023.103585

1

SCHOLARLY ARTICLE

Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging

Jun 2023DRUG DISCOVERY TODAY28(6):1-13

Co-authorsPio-Lopez L, Levin M

VIEW MORE INFO10.1016/J.DRUDIS.2023.103585THIS

SCHOLARLY ARTICLE

Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine

12 May 2023Patterns4(5)

Co-authorsMathews J, Chang A, Devlin L…1 more

VIEW PDF10.1016/J.PATTER.2023.100737

3

SCHOLARLY ARTICLE

Making and breaking symmetries in mind and life

14 Apr 2023Interface Focus13(3)

Co-authorsSafron A, Sakthivadivel DAR, Sheikhbahaee Z…3 more

VIEW PDF10.1098/RSFS.2023.0015

SCHOLARLY ARTICLE

The scaling of goals from cellular to anatomical homeostasis: an evolutionary simulation, experiment and analysis

14 Apr 2023Interface Focus13(3)

Co-authorsPio-Lopez L, Bischof J, LaPalme JV…1 more

VIEW PDF10.1098/RSFS.2022.0072

1

SCHOLARLY ARTICLE

The collective intelligence of evolution and development

Apr 2023Collective Intelligence2(2):263391372311683SAGE Publications

Co-authorsWatson R, Levin M

VIEW PDF10.1177/26339137231168355

SCHOLARLY ARTICLE

Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling

13 Mar 2023Physics Reports1004:1-31

Co-authorsCervera J, Levin M, Mafe S

10.1016/J.PHYSREP.2022.12.003

2

SCHOLARLY ARTICLE

There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines

1 Mar 2023Biomimetics8(1)

Co-authorsBongard J, Levin M

VIEW PDF10.3390/BIOMIMETICS8010110

4

SCHOLARLY ARTICLE

Transplantation of fragments from different planaria: A bioelectrical model for head regeneration

7 Feb 2023Journal of Theoretical Biology558

Co-authorsCervera J, Manzanares JA, Levin M…1 more

VIEW PDF10.1016/J.JTBI.2022.111356

SCHOLARLY ARTICLE

Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind

1 Jan 2023Animal Cognition

Co-authorsLevin M

VIEW PDF10.1007/S10071-023-01780-3

2

SCHOLARLY ARTICLE

Biological Robots: Perspectives on an Emerging Interdisciplinary Field

1 Jan 2023Soft Robotics

Co-authorsBlackiston D, Kriegman S, Bongard J…1 more

10.1089/SORO.2022.0142

1

SCHOLARLY ARTICLE

Cellular Competency during Development Alters Evolutionary Dynamics in an Artificial Embryogeny Model

1 Jan 2023Entropy25(1)

Co-authorsShreesha L, Levin M

VIEW PDF10.3390/E25010131

5

SCHOLARLY ARTICLE

Endless forms most beautiful 2.0: teleonomy and the bioengineering of chimaeric and synthetic organisms (July, blac073, 2022)

1 Jan 2023BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY138(1):141

Co-authorsClawson WP, Levin M

VIEW PDFVIEW MORE INFO10.1093/BIOLINNEAN/BLAC116

SCHOLARLY ARTICLE

Future medicine: from molecular pathways to the collective intelligence of the body

1 Jan 2023Trends in Molecular Medicine

Co-authorsLagasse E, Levin M

10.1016/J.MOLMED.2023.06.007

THE VOICE of Dr. Justin D. Pearlman, MD, PhD, FACC

PENDING

THE VOICE of  Stephen J. Williams, PhD

Ten TakeAway Points of Dr. Lustig’s talk on role of diet on the incidence of Type II Diabetes

 

1. 25% of US children have fatty liver
2. Type II diabetes can be manifested from fatty live with 151 million  people worldwide affected moving up to 568 million in 7 years
3. A common myth is diabetes due to overweight condition driving the metabolic disease
4. There is a trend of ‘lean’ diabetes or diabetes in lean people, therefore body mass index not a reliable biomarker for risk for diabetes
5. Thirty percent of ‘obese’ people just have high subcutaneous fat.  the visceral fat is more problematic
6. there are people who are ‘fat’ but insulin sensitive while have growth hormone receptor defects.  Points to other issues related to metabolic state other than insulin and potentially the insulin like growth factors
7. At any BMI some patients are insulin sensitive while some resistant
8. Visceral fat accumulation may be more due to chronic stress condition
9. Fructose can decrease liver mitochondrial function
10. A methionine and choline deficient diet can lead to rapid NASH development

 

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Updates to COVID-19 vaccine tracker

Posted in COVID-19, Mechanisms of infection by SARS-CoV-2, Population Health Management, Genetics & Pharmaceutical, SARS-CoV-2, SARS-CoV-2 circulating variants , SARS-CoV-2 Viral Variants, Treatment Protocols for COVID-19, Vaccinology, Virus Infective Acute Respiratory Syndrome: SARS-CoV on February 9, 2022| Leave a Comment »

Updates to COVID-19 vaccine tracker

Reporter: Aviva Lev-Ari, PhD, RN

 

On LPBI Group’s 

CORONAVIRUS, SARS-CoV-2 PORTAL @LPBI

http://lnkd.in/ePwTDxm

Launched on 3/14/2020

We cover the following Eight Pages of LPBI Group’s Coronavirus PORTAL

1. Breakthrough News Corner
2. Development of Medical Counter-measures for 2019-nCoV, CoVid19, Coronavirus
3. An Epidemiological Approach
4. Community Impact
5. Economic Impact of The Coronavirus Pandemic
6. Voices of Global Citizens: Impact of The Coronavirus Pandemic
7. Diagnosis of Coronavirus Infection by Medical Imaging and Cardiovascular Impacts of Viral Infection
8. Key Opinion Leaders Followed by LPBI

https://pharmaceuticalintelligence.com/coronavirus-portal/

Lead Curators are:

• Development of Medical Counter-measures for 2019-nCoV, CoVid19, Coronavirus, Aviva Lev-Ari, PhD, RN Lead Curator – e–mail Contact: AvivaLev-Ari@alum.berkeley.edu

UPDATED on 3/31/2020

COVID-19 Treatment and Vaccine Tracker This document contains an aggregation of publicly available information from validated sources. It is not an endorsement of one approach or treatment over another but simply a list of all treatments and vaccines currently in development.

• Number
• Type of Product – Treatment
• FDA-Approved Indications (Treatments)
• Clinical Trials
• Ongoing for Other Diseases
• Developer/ Researcher
• Current Stage of Development
• Funding Sources
• Anticipated Timing
• Sources

LEGEND

1. CCHF= Crimean-Congo Haemorrhagic Fever
2. CHIKV = Chikungunya Virus
3. DengV = Dengue Virus
4. FMD = Foot and Mouth Disease
5. EBOV = Ebola Virus
6. HAV = Hepatitis A Virus
7. HBV = Hepatitis B Virus
8. HIV = Human Immunodeficiency Virus
9. HPV = Human Papilloma Virus
10. Inf = Influenza
11. LASV = Lassa Fever Virus
12. MARV = Marburg Virus
13. MenB = Mengingitis B
14. MERS = Middle East Respiratory Syndrome
15. NIPV = Nipah Virus
16. NORV = Norovirus
17. RABV = Rabies Virus
18. RSV = Respiratory Syncytial Virus
19. RVF = Rift Valley Fever

20. SARS = Severe Acute Respiratory Syndrome

21. SIV = Simian Immunodeficiency Virus
22. TB = Tuberculosis
23. VEE = Venezuelan Equine Encephalitis Virus
24. VZV = Varicella Vaccine (Chickenpox)
25. YFV = Yellow Fever Virus
26. ZIKV = Zika Virus L

COVID-19 Treatment and Vaccine Tracker This document contains an aggregation of publicly-available information from validated sources. It is not an endorsement of one approach or treatment over another, but simply a list of all treatments and vaccines currently in development

• Antibodies from recovered COVID-19 patients N/A Celltrion Pre-clinical Start Phase 1 ~ Sept 2020 Korea Herald 4

• Antibodies from recovered COVID-19 patients N/A Kamada Pre-clinical BioSpace AbbVie 5

• Antibodies from recovered COVID-19 patients N/A Vir Biotech/WuXi Biologics/Biogen Pre-clinical Stat News Vir Biotech 6

• Antibodies from recovered COVID-19 patients N/A Lilly/Ab-Cellera (NIH Vaccines Research Center) Pre-clinical Start Phase 1 in late July 2020 Endpoints News

SOURCE

https://milkeninstitute.org/sites/default/files/2020-03/Covid19%20Tracker%20032020v3-posting.pdf

UPDATES to COVID-19 vaccine tracker

Posted 28 January 2022 | By Jeff Craven

SOURCE

https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker

 

The worldwide endeavor to create a safe and effective COVID-19 vaccine is bearing fruit. Dozens of vaccines now have been authorized or approved around the globe; many more remain in development.
 
To clarify the landscape for our readers, our vaccine tracker has been split in two. The first chart details vaccine candidates that are still in development to address the lack of vaccines and access in many countries around the world; the second chart lists vaccines that are authorized or approved by one or more country. To reveal in-depth information about each candidate, select the “Details” button above the chart or click on the green plus button next to each entry.
 
Information about the unprecedented public/private partnerships spawned by the COVID-19 public health emergency now can be found below the charts.
 
Our charts are updated every other week. If you wish to submit an update or notice an issue with this data, please email Focus at news@raps.org. 

Updated 28 January with new information on vaccines from Pfizer/BioNTech, Moderna, AstraZeneca, Gamaleya Research Institute, Janssen Vaccines, Sinovac, Bharat Biotech/Ocugen, Anhui Zhifei Longcom Biopharmaceutical, and Novavax as well as vaccine candidates from Walvax, Valneva, GSK/Sanofi, and Senai Cimatec.

 

Vaccine candidates in development

 

SHOW/HIDE DETAILS

 

Show  10 25 50 100  entries

Search:

	Candidate	Mechanism	Sponsor	Trial Phase	Institution
	Unnamed vaccine candidate	Recombinant vaccine (Sf9 cells)	WestVac Biopharma Co., Ltd.; West China Hospital; Sichuan University;	Phase 3	Jiangsu Province Centers for Disease Control and Prevention
	ARCoV	mRNA-based vaccine	Walvax Biotechnology Co., Ltd.; Abogen Biosciences Co. Ltd.; Yuxi Walvax Biotechnology Co., Ltd.	Phase 3	Xiangfen CDC
	Unnamed vaccine candidate	Plant-based adjuvant vaccine	Medicago; GSK; Dynavax	Phase 3	Medicago
	VLA2001	Inactivated vaccine	Valneva;UK National Institute for Health Research	Phase 3	Multiple NIHR testing sites
	Vidprevtyn	Recombinant protein vaccine	Sanofi; GlaxoSmithKline	Phase 3	Various
	Nanocovax	Recombinant vaccine (Spike protein)	Nanogen Biopharmaceutical	Phase 3	Military Medical Academy (Vietnam)
	V-01	Recombinant protein vaccine	Guangdong Provincial Center for Disease Control and Prevention; Gaozhou Municipal Center for Disease Control and Prevention; Zhuhai Livzonumab Biotechnology Co., Ltd.	Phase 3	Livzon Mabpharm Inc.
	Razi Cov Pars	Recombinant vaccine (Spike protein)	Razi Vaccine and Serum Research Institute	Phase 3	Tehran Rasoul Akram Hospital; Karaj, Hesarak, Razi Vaccine and Serum Research Institute
	GBP510	Nanoparticle vaccine	SK bioscience Co., Ltd.; GSK; University of Washington; CEPI	Phase 3	Various
	Noora	Recombinant protein vaccine	Baqiyatallah University of Medical Sciences	Phase 3

Showing 1 to 10 of 96 entries

Previous12345…10Next

Authorized/approved vaccines

 

SHOW/HIDE DETAILS

 

Show  10 25 50 100  entries

Search:

	Name	Vaccine Type	Primary Developers	Country of Origin	Authorization/Approval
	Comirnaty (BNT162b2)	mRNA-based vaccine	Pfizer, BioNTech; Fosun Pharma	Multinational	Albania, Andorra, Argentina, Aruba, Australia, Bahrain, Bangladesh, Bosnia and Herzegovina, Brazil, Brunei, Canada, Caribbean, Chile, Colombia, Costa Rica, Ecuador, European Union, Faroe Islands, Greenland, Hong Kong, Iceland, India, Indonesia, Iraq, Israel, Japan, Jordan, Kuwait, Lebanon, Liechtenstein, Macao, Malawai, Malaysia, Maldives, Mexico, Moldova, Monaco, Mongolia, New Zealand, Nigeria, North Macedonia, Norway, Oman, Palestine, Pakistan, Panama, Paraguay, Peru, Philippines, Qatar, Rwanda, Saint Vincent and the Grenadines, Saudi Arabia, Serbia, Singapore, South Africa, South Korea, Sri Lanka, Suriname, Switzerland, Taiwan, Thailand, Tunisia, Turkey, Ukraine, UAE, UK, US (16 and older), Uzbekistan, Vatican City, Vietnam, WHO
	Moderna COVID‑19 Vaccine (mRNA-1273); also called Spikevax	mRNA-based vaccine	Moderna, BARDA, NIAID	US	Andorra, Australia, Bangladesh, Bhutan, Brazil, Botswana, Canada, Colombia, European Union, Faroe Islands, Greenland, Guatemala, Honduras, Iceland, India, Indonesia, Israel, Japan, Liechtenstein, Malawai, Maldives, Mexico, Moldova, Mongolia, Nigeria, Norway, Palestine, Peru, Philippines, Qatar, Saint Vincent and the Grenadines, Serbia, Singapore, South Korea, Switzerland, Taiwan, Tajikistan, Thailand, United Kingdom, UAE, Ukraine, United States, Uzbekistan, Vietnam, WHO
	COVID-19 Vaccine AstraZeneca (AZD1222); also known as Vaxzevria and Covishield	Adenovirus vaccine	BARDA, OWS	UK	Afghanistan, Albania, Algeria, Andorra, Angola, Argentina, Armenia, Australia, Bahamas, Bahrain, Bangladesh, Barbados, Bhutan, Bolivia, Botswana, Brazil, Brunei, Cabo Verde, Cambodia, Canada, Cambodia, Caribbean, Chile, Colombia, Congo, Costa Rica, Djibouti, Dominican Republic, Ecuador, El Salvador, Egypt, Estonia, Eswatani, Ethiopia, European Union, Faroe Islands, Fiji, Gambia, Georgia, Ghana, Greenland, Guatemala, Guinea-Bissau, Guyana, Honduras, Hungary (SII), Iceland, India, Indonesia, Iran, Iraq, Ivory Coast, Japan, Jordan, Kenya, Kosovo, Kuwait, Lebanon, Lesotho, Liberia, Libya, Malawi, Malaysia, Maldives, Mali, Mauritius, Mexico, Moldova, Mongolia, Morocco, Myanmar, Namibia, Nepal, New Zealand, Nicaragua, Nigeria, North Macedonia, Norway, Oman, Pakistan, Palestine, Panama, Papua New Guinea, Peru, Philippines, Rwanda, Saint Vincent and the Grenadines, Samoa, Serbia, Seychelles, Sierra Leone, Somalia, South Korea, South Sudan, Sri Lanka, Sudan, Suriname, Taiwan, Tajikistan, Thailand, Timor Leste, Tonga, Togo, Tuvalu, Uganda, Ukraine, UK, Uzbekistan, Vietnam, WHO (Oxford; SII/SK), Yemen, Zambia
	Sputnik V	Recombinant adenovirus vaccine (rAd26 and rAd5)	Gamaleya Research Institute, Acellena Contract Drug Research and Development	Russia	Albania, Algeria, Angola, Antigua and Barbuda, Argentina, Armenia, Azerbaijan, Bahrain, Bangladesh, Belarus, Bolivia, Brazil, Chile, Congo, Djibouti, Ecuador, Egypt, Gabon, Ghana, Guatemala, Guinea, Guyana, Honduras, Hungary, India, Indonesia, Iran, Iraq, Israel, Jordan, Kazakhstan, Kenya, Kyrgyzstan, Laos, Lebanon, Maldives, Mali, Mexico, Moldova, Mongolia, Montenegro, Morocco, Myanmar, Namibia, Nicaragua, Nigeria, North Macedonia, Pakistan, Palestine, Panama, Paraguay, Republika Srpska, Russia (Sputnik Light), Saint Vincent and the Grenadines, San Marino, Serbia, Slovakia, Sri Lanka, Syria, Tunisia, Turkey, Turkmenistan, United Arab Emirates, Uzbekistan, Venezuela, Zimbabwe
	Sputnik Light	Recombinant adenovirus vaccine (rAd26)	Gamaleya Research Institute, Acellena Contract Drug Research and Development	Russia	Angola, Argentina, Armenia, Bahrain, Congo, Egypt, Iran, Kazakhstan, Kyrgyzstan, Laos, Mauritius, Mongolia, Nicaragua, Nigeria, Palestine, Paraguay, Philippines, Russia, San Marino, United Arab Emirates, Venezuela
	COVID-19 Vaccine Janssen (JNJ-78436735; Ad26.COV2.S)	Non-replicating viral vector	Janssen Vaccines (Johnson & Johnson)	The Netherlands, US	Andorra, Argentina, Australia, Bahrain, Bangladesh, Botswana, Brazil, Canada, Chile, Colombia, Denmark, EU, Faroe Islands, Greenland, Iceland, India, Indonesia, Iran, Kuwait, Liechtenstein, Malaysia, Malawai, Maldives, Mexico, Moldova, Nepal, New Zealand, Nigeria, Norway, Peru, Philippines, Saint Vincent and the Grenadines, South Africa, South Korea, Switzerland, Thailand, Tunisia, United Kingdom, US, WHO, Vietnam, Zambia, Zimbabwe
	CoronaVac	Inactivated vaccine (formalin with alum adjuvant)	Sinovac	China	Albania, Armenia, Azerbaijan, Bangladesh, Bolivia, Bosnia and Herzegovina, Botswana, Brazil, Cambodia, China, Chile, Colombia, Dominican Republic, Ecuador, Egypt, Georgia, Hong Kong, Indonesia, Kazakhstan, Laos, Libya, Malaysia, Mexico, Moldova, Nepal, Pakistan, Panama, Paraguay, Philippines, Singapore, South Africa, Sri Lanka, Tajikistan, Tanzania, Thailand, Timor-Leste, Togo, Tunisia, Turkey, Turkmenistan, Ukraine, Uruguay, Zimbabwe, WHO
	BBIBP-CorV/NVSI-06-07	Inactivated vaccine	Beijing Institute of Biological Products; China National Pharmaceutical Group (Sinopharm)	China	Afghanistan, Algeria, Angola, Argentina, Bahrain, Bangladesh, Barbados, Belarus, Bolivia, Bosnia and Herzegovina, Brazil, Brunei, Cambodia, Cameroon, Chad, China, Congo, Cuba, Dominican Republic, Egypt, Ethiopia, Equatorial Guinea, Gabon, Georgia, Guyana, Hungary, Indonesia, Iraq, Jordan, Kazakhstan, Kyrgyzstan, Laos, Libya, Macau, Malaysia, Malawai, Maldives, Mauritania, Mexico, Moldova, Mongolia, Montenegro, Morocco, Mozambique, Myanmar, Namibia, Nepal, Niger, Nigeria, North Macedonia, Pakistan, Papua New Guinea, Peru, Philippines, Qatar, Rwanda, Senegal, Serbia, Seychelles, Sierra Leone, Solomon Islands, Somalia, Sri Lanka, South Sudan, Sudan, Thailand, Turkmenistan, UAE, Vanuatu, Venezuela, Vietnam, WHO, Zambia, Zimbabwe
	EpiVacCorona	Peptide vaccine	Federal Budgetary Research Institution State Research Center of Virology and Biotechnology	Russia	Belarus, Russia, Turkmenistan
	Convidicea (PakVac, Ad5-nCoV)	Recombinant vaccine (adenovirus type 5 vector)	CanSino Biologics	China	Argentina, Chile, China, Ecuador, Hungary, Indonesia, Malaysia, Mexico, Moldova, Pakistan

Showing 1 to 10 of 34 entries

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COVID-19 vaccine initiatives

OWS: Operation Warp Speed is a collaboration of several US government departments including Health and Human Services (HHS) and subagencies, Defense, Agriculture, Energy and Veterans Affairs and the private sector. OWS has funded JNJ-78436735 (Janssen), mRNA-1273 (Moderna), and NVX‑CoV2373 (Novavax), V590 (Merck/IAVI), V591 (Merck/Themis), AZD1222 (AstraZeneca/University of Oxford), and the candidate developed by Sanofi and GlaxoSmithKline.
 
OWS is “part of a broader strategy to accelerate the development, manufacturing, and distribution of COVID-19 vaccines, therapeutics, and diagnostics.” Leaders of OWS say they could vaccinate as many as 20 million people by the end of the year and 100 million people by February.  
 
ACTIV: Within OWS, the US National Institutes of Health (NIH) has partnered with more than 18 biopharmaceutical companies in an initiative called ACTIV. ACTIV aims to fast-track development of drug and vaccine candidates for COVID-19.
 
COVPN: The COVID-19 Prevention Trials Network (COVPN) combines clinical trial networks funded by the National Institute of Allergy and Infectious Diseases (NIAID): the HIV Vaccine Trials Network (HVTN), HIV Prevention Trials Network (HPTN), Infectious Diseases Clinical Research Consortium (IDCRC), and the AIDS Clinical Trials Group.
 
COVAX: The COVAX initiative, part of the World Health Organization’s (WHO) Access to COVID-19 Tools (ACT) Accelerator, is being spearheaded by the Coalition for Epidemic Preparedness Innovations (CEPI); Gavi, the Vaccine Alliance; and WHO. The goal is to work with vaccine manufacturers to offer low-cost COVID-19 vaccines to countries. CEPI’s candidates from companies Inovio, Moderna, CureVac, Institut Pasteur/Merck/Themis, AstraZeneca/University of Oxford, Novavax, University of Hong Kong, Clover Biopharmaceuticals, and University of Queensland/CSL are part of the COVAX initiative. The US joined COVAX on 21 January. The most up-to-date forecast of COVAX’s vaccine supply can be found here. An interim distribution forecast, most recently published 3 February, can be found here.
 

 

© 2022 Regulatory Affairs Professionals Society.

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Tags: biologic, coronavirus, worldwide

SOURCE

https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker

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