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Authentic Relevance of LPBI Group’s Portfolio of IP as Proprietary Training Data Corpus for AI Initiatives at Big Pharma

Curators: Aviva Lev-Ari, PhD, RN and Stephen J. Williams, PhD

Updated on 11/29/2025

 

The Voice of Stephen J. Williams, PhD

Since the formation of the LPBI group in 2012, we have set as a goal to digitally curate and ontologize the biomedical literature.  These aspects of our mission, although not understandable to most at that time of our inception, was at the forefront of many academic efforts which became the springboard and initial conceptualization of today’s large language models.  In select universities like University of Illinois, University of Delaware, and the Technion, academics and researchers at Microsoft and Google, were laying the framework for  a semantic web, or Web 3.0.  Another company at the forefront of this idea was a company springing forth from Mathematica, Wolfram Research. This idea for a semantic web would entail the processes of curation, digitization, and ontology creation.  Their belief, such as ours, was  a precursor and much needed key to the puzzle of moving language from machine learning algorithms to the generative transformers used by artificial intelligence.

However as most efforts in this genre focused on general language, our efforts at LPBI Group were focused on the biomedical field, as we understood, from 2012, that the biomedical literature was unique, and so a unique strategy had to be developed to semantically understand biomedical text, even though at the time of 2012 GPTs were not even a concept.  However the potential for doing biomedical text analysis was there, and LPBI Group responded by developing a methodology of scientific curation which involved a multimodal strategy to curate, digitize, and ontologize biomedical findings and text.

It was about at the time of 2012 that other groups, mainly focused of drug development applications (for example at University of Indiana) recognized that new computational power of machine learning algorthims could be  useful in analyzing complex biological questions.  Please see our Synthetic Biology in Drug Discovery section of our Journal for more information on this. For instance, an early adopter of this strategy, a company called  Data2Discovery, one of the earliest AI for drug discovery startups, stated

We are able to improve drug discovery now as well as demonstrating new fast-cycle AI-driven processes that will have a revolutionary impact on drug discovery if fully implemented. We have had some dramatic successes, but we are just starting to discover the impact that data, knowledge graphs, AI and machine learning can together have on drug discovery.

We need all the expertise of academics, consortia, AI companies and pharma to make his happen, and it’s going to require some serious investment, and a big change of thinking. But the opportunity to get drug discovery out of the death spiral and framed for data-driven success is too important to pass up.

However the LPBI Group was cognizant of these changes occuring and pivoted to the developing natural language processing arena as well as ideas for the developing Blockchain technology.  This was more of a natural progression for the LPBI Group than a pivot (please read here).

This would be our Vision 2.0, to make biomedical text amenable for Natural Language Processing.   We utilized a few strategies in this regard, partnering with a company who was developing NLP for biomedical text analysis, and developing in house machine learning and NLP methods using the Wolfram language environment.  Our focus on structuring biomedical text (versus the highly structured genomics and omics data found in many omics related databanks) was prescient for the time.  As NLP and machine learning  efforts realized, biomedical text needs to have a structure much like genes, proteins and other molecular databases had been organized.  Therefore it was realized that structured data was imperative for efficient NLP analysis, a crux for the new GPT which was being developed (and in this mind still is a crux for current GPT and LLM models when it comes to biomedical text analysis).

Our strategy using our scientific curation methodology (as described below in links form our founder Dr. Aviva Lev-Ari, was proven to be highly efficient and amenable to NLP analysis, as a pilot with an NLP company noticed.  Most of the data they were using was unstructured and their first step involved annotation and structuring the text, as we had already performed for years.  This was critical as our text was able to pull out more concepts, relationships, in a faster time than NLP on sources such as PubMed available text.  We had also developed our own in house algorithms for NLP on our material, which is shown in some of our book offerrings and individual articles.

However with the advent of GPT it was thought all this was unnecessary.  However this idea that our strategy was outdated or irrelevent in the era of GPT was wholly  incorrect to the advocates of a sole GPT strategy to analyze biomedical text and data.  It is now understood that structure is needed as some of biomedical-centric GPT projects would find out, such as BioGPT.  We have many articles which attest to the lack of  accuracy and efficiency of these GPT architectures (seen here). These include failure rates in many areas of healthcare and biomedicine by sole reliance on GPT,

It was realized by many in the biomedical arena, especially those involved in NLP efforts, that there was much value in the semantic web 3.0 idea, and this was readily picked up by those spearheading effort to incorporate knowledge graphs with the new generative AI or GPT technology.  We have shown a clear example our scientific methodology of curation with ontology has better inference when combined with knowledge graphs and GPT than reliance on GPT alone

please read this article

Multiple Lung Cancer Genomic Projects Suggest New Targets, Research Directions for Non-Small Cell Lung Cancer

at https://pharmaceuticalintelligence.com/2014/09/05/multiple-lung-cancer-genomic-projects-suggest-new-targets-research-directions-for-non-small-cell-lung-cancer/

As shown here in this article

This update was performed by the following methods:
A. GPT 5 Text analysis and Reasoning
B. Insertion of Knowledge Graph on topic Curation of Genomic Analysis from Non Small Cell Lung Cancer Studies  from Nodus Labs using InfraNodus software
C. Domain Knowledge Expert evaluation of the Update outcomes
This article has the following Structure:
Part A: Introduction to LLM, Knowledge Graph software InfraNodus, ChatGPT5 and Background Information on curated material for Test Case
Part B: InfraNodus Analysis of manual curation and Knowledge Graph Creation
Part C: Chat GPT 5 Analysis of Manually Curated Material
Part D: Curation entitled Multiple Lung Cancer Genomic Projects Suggest New Targets, Research Directions for Non-Small Cell Lung Cancer originally published on 09/05/2014
Results of Article Update with GPT 5
1. GPT5 alone was not able to understand the goal of the article, namely to determine knowledge gaps in a particular research area involving 5 genomic studies on lung cancer patients
2. GPT5 alone was not able to group concepts or comonalities between biological pathways unless supplied with a manually curated list of KEGG pathways from a list of mutated genes.  However this precluded any effect that fusion proteins had on the analysis and so GPT5 would only concentrate on mutated genes commonly found in literature
3. GPT was not able to access some of the open Access databases like NCBI Gene Ontology database
Results of Article Update with KnowledgeGraph presentation to GPT 5
4. As the Knowledge Graph understood the importance of fusion proteins and transversions, the knowledgegraph augmented the GPT analysis and so enriched the known pathways as well as could correctly identify the less represented pathways in the knowledge graph
5.  This led to the identification of many novel signaling pathways not identified in the original analysis, and was able to perform this task with ease and speed

6. GPT with InfraNodus Analysis was able to propose pertinent questions for future research (the goal of the original curation) such as:

  • How does the interaction between [[EGFR]] mutations and sex-specific gene alterations, including [[RBM10]], influence treatment outcomes in lung adenocarcinoma?
  • How does the intersection of mutational patterns from smoking influence pathway activation in NSCLC, and can identifying these interactions improve targeted therapy development?
Novelty in comparison to Original article published on 09/05/2014
7. it appears that manual curation is necessary to assist in the building of relevant knowledge graphs in the biomedical fields to augment generative AI analysis
8. by itself, generative AI is not optimized for inference of higher concepts from biomedical text, and therefore, at this point, requires the input from human curators developing domain-specific knowledge graphs
9.  The combination of ChatGPT5 and Knowledge graphs of this manually curated biomedical text added a further layer of complexity of gaps of knowledge not seen in the original curations including the need to study noncanonical signaling pathways like WNT and Hedgehog in smoker versus nonsmoker cohorts of lung cancer patients

The Voice of Aviva Lev-Ari, PhD, RN

LPBI Group’s Portfolio of Digital IP Assets as Proprietary Training Data Corpus for AI in Medicine, in Life Sciences, in Pharmaceutical and in Health Care Applications

The Portfolio of Digital IP Assets by Class is a rare, defensible asset, privately-held debt-free by LPBI Group’s founder. The content, aka a Data Corpus is best designed for the Training and Pre-Training of Foundation Multimodal Models in Health Care. 

#HealthcareAI

#FoundationModels

#ProprietaryTrainingData

LPBI Group is offering transfer of ownership, in full, a privately held, multimodal healthcare training corpus leveraging propriety unique data set curated by domain experts and mapped to a living ontology for GenAI creating defensibility.

The Portfolio of IP spans:

  • 6,250+ articles (~2.5MM views),
  • 48 e‑books (EN/ES) (+152,000 page downloads),
  • 100+ e‑Proceedings with +50 Tweet collections,
  • 7,500+ biological images with expert context, and
  • 300+ Audio podcasts on Life Sciences breakthroughs.

Each asset (Use Case: Scientific Article) has timestamps, author/role labels, crosslinks, and view histories.

  • Metadata export exists; full text and media transfer via WordPress/Amazon account control for immediate ingestion.
  • Rights are centrally assigned with explicit model‑training data by domain-aware for model implementation for Small Language Models or Large Language Models.

Strategic acquirers in Big Pharma of Vertical AI startups (i.e., LPBI Group) with data‑moat strategies

Pharma strategics Acquire LPBI’s end‑to‑end, rights‑clean healthcare knowledge base to accelerate R&D, medical affairs, and safety. Ideal for and with acceleration of R&D, medical affairs, and safety. Emphasize compliant internal copilots and evidence synthesis enabled by expert curation and living ontology. Close with rapid onboarding under NDA  Metadata export plus full text/media transfer for rapid onboarding. Full acquisition only.

Subject: Buy the moat: full acquisition of expert healthcare corpus with clean rights

We’re selling the entire asset: a privately held, multimodal healthcare corpus with centralized training rights and an exportable ontology, validated on gene–disease–drug extraction. It’s ingest‑ready and transfers cleanly via account control plus a metadata export. If owning differentiated data is critical for your agent or workflow, we can provide a diligence preview under NDA.

compliant internal copilots and evidence synthesis enabled by expert curation and living ontology. Close with rapid onboarding under NDA

Five Examples of Domain-aware for model implementation for Small Language Models – English Edition & Spanish Edition

Series A: Cardiovascular Diseases ($515) – Six Volumes

https://www.amazon.com/gp/product/B07P981RCS?ref_=dbs_p_mng_rwt_ser_shvlr&storeType=ebooks

Six Examples of Domain-aware in the Specialty of Cardiovascular Diseases

  • Series A, Volume One

Perspectives on Nitric Oxide in Disease Mechanisms2013

http://www.amazon.com/dp/B00DINFFYC $75

  • Series A, Volume Two 

Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation, 2015

http://www.amazon.com/dp/B018Q5MCN8 $75

  • Series A, Volume Three

Etiologies of Cardiovascular Diseases – Epigenetics, Genetics and Genomics2015

http://www.amazon.com/dp/B018PNHJ84 $75

  • Series A, Volume Four

Therapeutic Promise: Cardiovascular Diseases, Regenerative & Translational Medicine, 2015

http://www.amazon.com/dp/B019UM909A $75

  • Series A, Volume Five

Pharmacological Agents in Treatment of Cardiovascular Diseases2018

https://www.amazon.com/dp/B07MGSFDWR  $115

  • Series A, Volume Six:

Interventional Cardiology for Disease Diagnosis and Cardiac Surgery for Condition Treatment2018

https://www.amazon.com/dp/B07MKHDBHF $100

 

Series B: Frontiers in Genomics ($200) – Two Volumes

https://www.amazon.com/gp/product/B0BSDPG2RX?ref_=dbs_p_pwh_rwt_anx_b_lnk&storeType=ebooks

Series C: Cancer & Oncology ($175) – Two Volumes

https://www.amazon.com/gp/product/B0BSDWVB3H?ref_=dbs_p_mng_rwt_ser_shvlr&storeType=ebooks

Series D: Immunology ($325) – Four Volumes

https://www.amazon.com/gp/product/B08VVWTNR4?ref_=dbs_p_pwh_rwt_anx_b_lnk&storeType=ebooks

Series E: Patient-Centered Medicine ($274) – Four Volumes

https://www.amazon.com/gp/product/B0BSDW2K6C?ref_=dbs_p_mng_rwt_ser_shvlr&storeType=ebooks

One Example of Domain-aware for model implementation for Large Language Models

Eighteen volumes in the English Edition and 19 volumes in the Spanish Edition including 2,728 articles by biomedical professionals are available.

https://www.amazon.com/s?k=Aviva+Lev-Ari&i=digital-text&rh=n%3A133140011&ref=nb_sb_noss

The electronic books are collections of curated articles in biomedical science. The electronic Tables of Contents (eTOCs) of each volume was designed by a senior editor with expertise in the subjects covered in that volume. The curations use as sources published research findings in peer-reviewed scientific journals together with expert added interpretations.

The e-books are designed to make the latest research in the Five Bilingual BioMed e-Series – 37 volumes accessible to practicing health care professionals. These five e-Series cover the following medical specialties:

  • Cardiovascular diseases and therapies,
  • Genomics,
  • Cancer etiology and oncological therapies,
  • Immunology, and
  • Patient-centered precision medicine.

The material in these volumes can greatly enhance medical education and provide a resource for continued updating and education for health care professionals. In addition to the 37 e-books, LPBI has published more than 6,000 articles in its online scientific journal “PharmaceuticalIntelligence.com”, which has received 2.5 million views since its launch in 4/2012, Top articles had more than 18,000 views.

The Portfolio is:

  • rights‑clean,
  • expert‑curated healthcare corpus
  • mapped to a living Ontology,
  • already packaged for immediate model ingestion and
  • suitable for safe pre-training, evals, and fine‑tuning.

If healthcare domain data is on your roadmap, this is a rare, defensible asset worth a preview.

LPBI Group is offering transfer of ownership, in full, a privately held, multimodal healthcare training corpus leveraging propriety unique data set curated by domain experts and mapped to a living ontology for GenAI creating defensibility. It spans 6,250+ articles (~2.5MM views), 48 e‑books (EN/ES) (+151,000 page downloads), 100+ e‑proceedings with +50 tweet collections, 7,500+ biological images with expert context, and 300+ Audio podcasts on Life Sciences breakthroughs. Each asset has timestamps, author/role labels, crosslinks, and view histories. Rights are centrally assigned with explicit model‑training data by domain-aware for model implementation for Small LMs or LLMs. Metadata export exists; full text and media transfer via WordPress/Amazon account control for immediate ingestion.

Leaders in Pharmaceutical Business Intelligence Group, LLC, Doing Business As LPBI Group, Newton, MA

Full acquisition only: LPBI Group’s Healthcare Training Data Corpus

  • Scientific articles
  • e‑Books in Medicine
  • e‑Proceedings,
  • Biological images
  • Podcasts

#HealthcareAI #FoundationModels #TrainingData

Contact Founder: avivalev-ari@alum.berkeley.edu

PharmaceuticalIntelligence.com

About the Founder

  • LPBI Group’s Legacy and Biography of Aviva Lev-Ari, PhD, RN, Founder & Director, INTERACTIVE CHAT with Grok, created by xAI

https://pharmaceuticalintelligence.com/2025/04/30/interactive-chat-with-grok-created-by-xai-lpbi-groups-legacy-and-biography-of-aviva-lev-ari-phd-rn-founder-director/ 

For Recognitions and a DETAILED BIO by Perplexity.ai and Gemini 2.5 Pro (experimental), see

  • “Show Thinking” by AI Deep Research: The AI-generated Biography Description of Aviva Lev-Ari, PhD, RN, Founder of PharmaceuticalIntelligence.com by Perplexity.ai and by Google’s Gemini 2.5 Pro (experimental)

https://pharmaceuticalintelligence.com/2025/04/29/show-thinking-by-ai-deep-research-the-ai-biography-description-of-aviva-lev-ari-phd-rn-founder-of-pharmaceuticalintelligence-com-by-perplexity-ai-and-by-googles-gemini-2/

Authentic Relevance of LPBI Group’s Portfolio of IP as Proprietary Training Data Corpus for AI Initiatives at Big Pharma

On 11/14, 2025, Dr. Lev-Ari asked @Grok about AI Initiatives at a Big Pharma, i.e., Pfizer.

@Grok response is presented, below

URL SOURCE:

https://x.com/i/grok/share/0ol5VOJsEYs11baXq4xkzNb0h

Pfizer’s AI Initiatives Overview

Pfizer, a global pharmaceutical leader, has integrated artificial intelligence (AI) and machine learning (ML) across its operations to accelerate drug discovery, enhance clinical trials, improve manufacturing, and drive patient-centric innovations. These efforts aim to reduce development timelines, boost efficiency, and address challenges like rare disease detection. As of late 2025, Pfizer’s AI strategy emphasizes internal expertise, cloud-based tools (primarily with AWS), and cross-industry collaborations, with a focus on multimodal data analysis and generative AI. Below is a breakdown of key initiatives, drawn from recent developments.

1. Pfizer AI Cloud Transformation (PACT) Program Launched in 2021 with AWS, PACT is a prototyping accelerator for AI/ML applications in lab, clinical manufacturing, and supply chain efforts. It has pursued 14 projects, with five now in production. Key outcomes include:

  • Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis.
  • 55% reduction in infrastructure costs through cloud optimization.
  • Exploration of virtual/augmented reality for training, with rapid prototyping to test feasibility. This program fosters “fail-fast” innovation, enabling quick iteration on ideas like AI-driven predictive modeling.

2. Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D, cutting years off traditional timelines (e.g., from 8–10 years to months for certain candidates).

  • COVID-19 Initiatives: AI optimized molecular searches for PAXLOVID (oral antiviral), enabling intravenous-to-oral pivots. During vaccine development, the Safety Data Quality (SDQ) tool—a custom AI for clinical trial data management—saved a full month of analysis via the Breakthrough Change Accelerator sandbox.
  • Precision Medicine and Subpopulation Identification: Advanced ML (classical and deep learning) analyzes molecular datasets from trials to predict patient responses, informing trial design, first-in-human studies, and oncology/inflammatory disease targeting. This has doubled clinical success rates to ~20% (vs. industry 7–10%).
  • ML Research Hub: Pfizer’s Cambridge, MA-based Biomedical Data Science group builds internal talent for AI in genome sciences, predicting disease outcomes and treatment efficacy using techniques from tech giants like Google.

3. Clinical Trials and Regulatory Efficiency AI automates content creation across the drug lifecycle, from lab data to regulatory docs and patient booklets, ensuring quality and speed.

  • Predictive Regulatory Tools: ML models forecast regulator queries, proactively addressing safety concerns to build trust and shorten approvals.
  • Decentralized Trials: The “Clinical Trial Anywhere” model uses AI to integrate remote data (e.g., home health visits), improving recruitment/retention and generating real-world evidence.
  • Inventory and Supply Chain: AI predicts vaccine storage issues, pioneered during COVID distribution.

4. Disease Detection and Diagnostics

  • ATTR-CM Initiative: Through the ASPIRE collaboration (with Amyloidosis Research Consortium), AI analyzes EHRs, ECGs, and echocardiograms to detect transthyretin amyloid cardiomyopathy earlier, targeting underdiagnosed heart failure cases.
  • Rare Diseases: ML models identify symptoms in large datasets, mapping the immune system for better predictions.

5. Generative AI and Operational Tools

  • Charlie Platform: Rolled out in 2024 for marketing, this gen AI tool (named after co-founder Charles Pfizer) generates compliant content like emails, presentations, and medical article drafts. Trained on approved product data, it streamlines physician targeting and customer insights.
  • Scientific Data Cloud: AWS-powered centralization of data/ML capabilities, enabling faster research and treating 1.3 billion patients in 2022. It supports gen AI via Amazon SageMaker/Bedrock for manufacturing efficiency.
  • Global Health Grants: Through the Pfizer Foundation’s AI Learning Lab, funding supports AI for equitable healthcare access, e.g., biometric tools for community care.

6. Partnerships and Education

  • Collaborations: With AWS for cloud AI; IMI Big Picture for a 3M-sample disease database; IIT Madras for the 2025 AIPM Symposium on AI in pharma (focusing on drug discovery and precision medicine).
  • Talent and Events: Hosting webinars on AI in manufacturing (e.g., predictive maintenance, regulatory submissions) and engaging leaders like Dr. Subha Madhavan on AI for biomedical data integration.
  • Strategic Focus: $500M R&D reinvestment by 2026 targets AI for productivity, part of $7.7B cost savings. Emphasis on ethical AI, diverse datasets, and competing with global biotech advances (e.g., China’s AI in CRISPR).

Pfizer’s approach balances operational efficiency with transformative R&D, positioning AI as a core enabler rather than a standalone focus. Ongoing investments, like cloud migrations saving $47M annually and reducing CO2 emissions, underscore sustainability. For the latest, monitor Pfizer’s investor updates or events like AWS re:Invent.

Responsiveness to Big Pharma AI Initiatives by LPBI Group’s Digital IP Portfolio:

  • Scientific articles
  • e‑Books in Medicine
  • e‑Proceedings,
  • Biological images
  • Podcasts
AI Initiative at Big Pharma

i.e., Pfizer

Composed @Grok

LPBI Group’s Digital IP Asset:

Journal articles

N = 6,250

Composed by Aviva Lev-Ari

Generative AI tools

that save scientists up to 16,000 hours annually in literature searches and data analysis.

Generative AI tools searching LPBI’s Proprietary data in addition to Public Domain data sources

Journal ONTOLOGY used to optimize context classification selected for search

Drug Discovery and Development Acceleration

Pfizer uses AI, supercomputing, and ML to streamline R&D timelines

–       Run prompts by category of research on the following three dyads

–       Run ML across categories of research for these three dyads

-Gene-disease

-Disease-drug

-Gene-drug

 

Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Curation competences:

  • content creation across the drug lifecycle, from lab data to regulatory docs
Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

Heart Failure Diagnosis by Early detection of transthyretin amyloid cardiomyopathy

–       Journal published ~30 curations by Dr. Larry on this subject ATTR-CM

–       Run NLP on this Corpus

Rare diseases:

Journal published 560 articles on Rare diseases

–       Run ML on this Corpus

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker /Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable access to care and tools for community care

Content generated in the Journal can become “generated compliant content” if run on the Charlie Platform.

–       For REUSE content in context

 

Entire Corpus of 9 Giga bytes can be ingested to Pfizer Foundation’s AI Learning Lab

–       Run prompts against it

–       Journal’s Content to be used for Internal staff expertise development

–       Journal’s Content for Leadership development

Partnerships and Education

–       Collaborations: IMI Big Picture for 3M – sample disease database

–       AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

–       Webinars of AI for biomedical data integration

–       Webinar on AI in Manufacturing

The Journal had published 547 articles in Precision Medicine

 

The Journal had published 1,114 articles in Drug Discovery

 

The Journal had published 701  articles in Drug Delivery

 

The Journal had published 3,615 articles on subject matter “Disease”

 

The Journal had published 738 articles on Biomedical topics

 

The Journal had published 425 articles on Artificial Intelligence (AI)

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

The Journal had published 432 articles on CRISPR

 

Productivity derived from Journal’s content:

–       As a result of the fact that ~70% of the Journal’s articles are curations written by Domain Knowledge Experts subjectively expressing theirs clinical interpretations of basic and primary research – the productivity of the knowledge workers at any Big Pharma would increase vastly.

–       If Grok and Claude would run on LPBI Group’s Digital IP Corpus, a scientific revolution will emerge

–       It is not combinatorics applied to molecules with 98% futile results!!!

it is the IQ of Gifted HUMANS, of domain knowledge experts generating content using individual CREATIVITY no Quantum or Super Intelligence which is not in existence, YET.

–       Foundation Models in Healthcare depends on the OUTPUT of the human creative mind. AI takes keyword (classic search) and concepts (semantic search) and run frequency of occurrence and predict the nest word, one word after the next one.

@@@@@@@

AI Initiative at Big Pharma

i.e., Pfizer

LPBI Group’s Digital IP Asset:

e-Books

Domain-aware Editorials and Curations

Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis. The electronic Table of Contents of every e-book is a CONCEPTUAL MASTER PIECE of one unique occurrence in Nature generated by the Editor, or the Editors that had

–       Commissioned articles for the e-Book

–       Had selected articles from collections of Categories of Research created by domain knowledge experts

–       Had reviewed the TOTALITY of the Journal’s Ontology and found new concept to cover in the e-Book not originally planned

Had incorporated Highlights of Lectures given at 100 Conferences LPBI Group’s Dr. Lev-Ari and Dr. Willians had cover in Real Real, by invitation, only as PRESS.

–       The vision of the Editor-in-Chief of the BioMed e-Series reflects the BIG PICTURE of Patient care delivery.

–       UC, Berkeley PhD’83

–       Knowledge student and Knowledge worker, 10/1970 to Present

–       Conceptual pioneer of 26 algorithms in Decision Science of Operations Management decision support systems

–       2005 to Present in the Healthcare field.

–       2005-2012: Clinical Nurse Manager in Post-acute SNF settings and Long-term Acute care Hospital Supervisor – had developed a unique view on Diagnosis, Therapeutics and Patient care delivery

–       The BioMed e-Series is the EPITOM of human CREATIVITY in Healthcare an OPUS MAGNUM created by collaboration of top Scientists, Physicians and MD/PhDs

–       The 48 e-Books Published by LPBI Group – represent the ONLY one Publisher on Amazon.com with +151,000 pages downloaded since the 1st e-book published on 6/2013 and since Pay-per-View was launched by Amazon.com in 2016.

Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D timelines Two volumes on the BioMed e-Series were subjected to Medical Text Analysis with AI, ML, Natural Language Processing (NLP).

–       Cancer, Volume 1 (In English, part of the Spanish Edition, Series C)

–       Genomics, Volume 2 (In English, part of the Spanish Edition, Series B)

–       GPT capabilities are warranted to attempt to subject to ML Analytics every book of the MUTUALLY EXCLUSIVE 48 URLs provided by Amazon.com to LPBI Group, the Publisher.

–       5 URLs for 5 Bundles in The English Edition: Series A,B,C,D,E – English Edition

–       All books in each series – 5 Corpuses for domain-aware Small Language Model in English

–       All books in each series – 5 Corpuses for domain-aware Small Language Model in Spanish

–       5 URLs for 5 Bundles in The Spanish Edition: Series A,B,C,D,E –Spanish Edition

 

Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

–       No one had attempted ML on every book, only two books were analyzed by ML.

–       No one had attempted ML on all the Volumes in any of the 5 Series.

–       No one had attempted ML on all the 48 books

–       WHEN that will be done – a REVOLUTION on Disease Detection and Diagnostics will be seen for the first time because the totality of these 48 books represent the Brains of Human Experts

 

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker/Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable access to care and tools for community care

Add the content of all the Books to Charlie Platform
Partnerships and Education

 

Collaborations: IMI Big Picture for 3M – sample disease database

 

AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

 

Webinars of AI for biomedical data integration

 

Webinard on Ai in Manufacturing

e-Books are the SOURCE for Education

–       Offer the books as Partnership sustenance

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

URLs for the English-language Edition by e-Series:

Series A: Cardiovascular Diseases ($515)

https://www.amazon.com/gp/product/B07P981RCS?ref_=dbs_p_mng_rwt_ser_shvlr&storeType=ebooks

Series B: Frontiers in Genomics ($200)

https://www.amazon.com/gp/product/B0BSDPG2RX?ref_=dbs_p_pwh_rwt_anx_b_lnk&storeType=ebooks

Series C: Cancer & Oncology ($175)

https://www.amazon.com/gp/product/B0BSDWVB3H?ref_=dbs_p_mng_rwt_ser_shvlr&storeType=ebooks

Series D: Immunology ($325)

https://www.amazon.com/gp/product/B08VVWTNR4?ref_=dbs_p_pwh_rwt_anx_b_lnk&storeType=ebooks

Series E: Patient-Centered Medicine ($274)

https://www.amazon.com/gp/product/B0BSDW2K6C?ref_=dbs_p_mng_rwt_ser_shvlr&storeType=ebooks

 

@@@@@@@

AI Initiative at Big Pharma

i.e., Pfizer

LPBI Group’s Digital IP Asset:

e-Proceedings: N = +100, and

Tweet Collections: N = +50

Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D timelines List of all e-Proceeding of +100 TOP Conferences in Biotech, in Medicine, in Genomics, in Precision Medicine

https://pharmaceuticalintelligence.com/press-coverage/part-two-list-of-biotech-conferences-2013-to-present/

In these conferences the Frontier of Science was presented, ofter BEFORE publication findings were revealed. These Proceedings are the ONLY written record of the events. They are privately-held, now for the first time available for Transfer of Ownership 

The Tweet Collection are QUOTES of speakers on record. NOT ELSEWHERE available by name of speaker and affiliation

Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker/Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable  access to care and tools for community care

Ingest to Charlie Platform ALL e-Proceedings of ALL Conferences

 

Apply GPT:

Training Data:

–       One conference at a time

–       All Conference on ONE subject matter, i.e., Immunotherapy, Oncolytic Virus Immunotherapy, Immune Oncology

Partnerships and Education

–       Collaborations: IMI Big Picture for 3M – sample disease database

–       AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

–       Webinars of AI for biomedical data integration

–       Webinar on Ai in Manufacturing

Use Past Conference Agendas to build Future Conference Agendas

Use Speakers Lists to invite speakers/consultants to your events

Use topics covered in Conferences for Employee training & and in-house Leadership development

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

Having access to +100 e-Proceedings vs Not having access to this resource is a make or break in fine-tuning Corporate Branding: All your competitors attended and had sent Speakers

  • LPBI Group’s e-Proceedings is the only record in one URL

@@@@@@

AI Initiative at Big Pharmas

i.e., Pfizer

LPBI Group’s Digital IP Asset:

Biological Images selected by Experts embedded in original Text (Prior Art)

Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D timelines Gallery of ~8,000 Biological images and captions is a Treasure TROVE for scientific article writing, Presentation preparations. This Media Gallery is an Art collection of top Scholars in Medicine and Biology
Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

Gallery of ~8,000 Biological images and captions is a Treasure TROVE for Disease Detection and Diagnostics

 

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker/Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable  access to care and tools for community care

  • Ingest into Charlie Platform the Media Gallery for generation of Medical article drafts
Partnerships and Education

–       Collaborations: IMI Big Picture for 3M – sample disease database

–       AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

–       Webinars of AI for biomedical data integration

–       Webinar on Ai in Manufacturing

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

@@@@@@

AI Initiative at Big Pharma

i.e., Pfizer

LPBI Group’s Digital IP Asset:

Library of Audio and Video Podcasts

N = +300

Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D timelines Review ALL SCIENTIFIC BREAKTHROUGHS

  • Two criteria for Classifications used by Prof. Marcus W. Feldman and by Dr. Stephen J. Williams to generate the two classifications

https://pharmaceuticalintelligence.com/biomed-audio-podcast-library-lpbi-group/

Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

Aviva Lev-Ari, PhD, RN, Stephen J. Williams, PhD and Prof. Marcus W. Feldman Health Care Policy Analysis derived from the Farewell remarks from AMA President Jack Resneck Jr., MD | AMA 2023 Annual Meeting

LISTEN to Audio Podcast

Future of Medicine

https://pharmaceuticalintelligence.com/2023/06/10/health-care-policy-analysis-derived-from-the-farewell-remarks-from-ama-president-jack-resneck-jr-md-ama-2023-annual-meeting/

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker/Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable  access to care and tools for community care

  • Ingest to Charlie Platform all +300 Podcasts for Foundation’s AI Learning Lab
Partnerships and Education

–       Collaborations: IMI Big Picture for 3M – sample disease database

–       AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

–       Webinars of AI for biomedical data integration

–       Webinard on Ai in Manufacturing

  • Use Podcast for Education
  • Use Podcast as Hybrid: Start presentation with a Podcast continue with a life interview

Examples of an Audio Podcast of Scientists on LPBI Group Team in the past:

  • Podcast with Dr. Larry H. Bernstein, MD, FCAP, Interview by Gail S. Thornton, PhDc, Narrator’s Voice: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/audio-podcasts/podcast-with-dr-larry-h-bernstein-md-fcap-interview-by-gail-s-thornton-phdc-narrators-voice-stephen-j-williams-phd/

  • Podcast with Prof. Marcus W. Feldman, PhD, Biology Department, Stanford University, Interview by Gail S. Thornton, PhDc

https://pharmaceuticalintelligence.com/audio-podcasts/podcast-with-prof-marcus-w-feldman-phd-biology-department-stanford-university-interview-by-gail-s-thornton-phdc/

  • Podcast with Dr. Sudipta Saha, PhD, Interview by Gail S. Thornton, PhDc, Narrator’s Voice: Gail S. Thornton, PhDc

https://pharmaceuticalintelligence.com/audio-podcasts/podcast-with-dr-sudipta-saha-phd-interview-by-gail-s-thornton-phdc-narrators-voice-gail-s-thornton-phdc/

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

Dr. Lev-Ari Prompted @Grok on 11/18/2025:

AI-Driven Cost Savings in Big Pharma   

@Grok responded:

AI-Driven Cost Savings in Big PharmaArtificial intelligence (AI) applications across the pharmaceutical value chain—particularly in drug discovery, clinical trials, and operations—have the potential to generate substantial savings for major pharmaceutical companies (often referred to as “Big Pharma”). Based on recent industry reports and analyses from 2024-2025, these savings vary by application but could collectively reach tens of billions annually by the late 2020s. Projections indicate AI could add up to 11% in value relative to revenue for biopharma firms over the next five years through productivity gains and cost reductions. Below, I break down the estimated savings levels by key areas, drawing from credible sources like McKinsey, Deloitte, IQVIA, and others.

  1. Clinical Trials

  • Annual Industry-Wide Savings: By 2030, AI integration into 60-70% of clinical trials could save the pharmaceutical industry $20-30 billion per year through faster timelines, better patient matching, and reduced administrative costs.
  • Per-Trial Cost Reduction: AI can cut trial costs by up to 70% and shorten durations by 80%, enabling quicker regulatory submissions (40% faster) with 50% improved cost efficiency. For example, AstraZeneca reported up to 25% shorter trial durations in cancer drug studies using AI for dose optimization and biomarker identification.
  • Specific Efficiency Gains: Feasibility surveys can see 90% time reductions using AI/ML tools.
  1. Drug Discovery and Development

  • R&D Cost Drop: AI could reduce drug discovery costs by up to 40%, with overall development timelines shrinking from 5 years to 12-18 months (an 80% cut in some cases). From discovery to preclinical candidate stage, timelines can decrease by up to 50%.
  • Total Clinical Development Savings: Projected at $25 billion across the sector, driven by AI-accelerated pipelines.
  1. Operations and Broader Impacts

  • Value Relative to Revenue: Biopharma AI investments may yield up to 11% additional value (e.g., via cost efficiencies and revenue growth) over five years. For related medtech segments, savings could hit 12% of total revenue within 2-3 years.
  • Operating Profits Boost: By 2030, AI could add $254 billion in annual operating profits industry-wide through productivity jumps (e.g., 50-100% in quality control) and lead time reductions (60-70%).
  • Time-to-Market: Up to 10% faster overall, with production KPIs improving revenue by 25%.

These estimates assume scaled adoption, with global AI spending in pharma rising from ~$3 billion in 2025 to $22-25 billion by 2027-2030. Challenges like high initial costs and data infrastructure may temper short-term gains, but early adopters (e.g., Pfizer, Novartis) are already seeing ROI. For context, the global pharma market is projected at $1.6 trillion by 2025, so even modest percentages translate to billions in savings. If you need details on a specific AI use case or company, let me know!

SOURCE

https://x.com/i/grok?conversation=1990851703051104519

 

Dr. Lev-Ari Prompted @Grok on 11/17/2025:

Pfizer, its competitors by size, market share, product lines and Investment in AI technologies

Grok responded

https://x.com/i/grok?conversation=1990458795936354506

Overview of Pfizer and Key CompetitorsPfizer is one of the world’s largest pharmaceutical companies, with a strong focus on innovative medicines and vaccines. Its primary competitors include Merck & Co., Johnson & Johnson (J&J), Roche, Novartis, and now AstraZeneca, based on revenue leadership and market overlap in areas like oncology, immunology, and vaccines. These companies dominate the global pharmaceutical industry, which is projected to reach $1.21 trillion in revenue by 2025. Below, I compare them across size (measured by 2024 revenue and employees), market share (approximate global pharma share based on 2024 revenues), product lines (key therapeutic areas and top products), and investments in AI technologies. Data reflects the latest available figures as of late 2025.
Here are the same comparisons with more concise tables (2024 data, latest available as of Nov 2025):
Size (2024 Revenue & Employees)
Company
Revenue (USD B)
Employees
Merck & Co.
64.2
70,000
Pfizer
63.6
88,000
Roche
~58.3
103,000
J&J (pharma only)
57.8
138,000
AstraZeneca
54.1
94,300
Novartis
~50.0
76,000
Approx. Global Pharma Market Share
Company
Share %
Merck & Co.
4.3
Pfizer
4.2
J&J / Roche
3.9
AstraZeneca
3.6
Novartis
3.3
Key Product Lines & Top Sellers (2024 revenue, USD B)
Company
Main Areas
Top Products (revenue)
Pfizer
Vaccines, cardiology, oncology
Eliquis (7.3), Prevnar (6.4), Vyndaqel (5.4)
Merck & Co.
Oncology, vaccines
Keytruda (25.0), Gardasil (8.6)
J&J
Immunology, oncology
Stelara (10.9), Darzalex (9.7)
AstraZeneca
Oncology, CVRM, respiratory
Farxiga (7.7), Tagrisso (6.6), Enhertu (4.0)
Roche
Oncology, neurology, hemophilia
Ocrevus (5.7), Hemlibra (4.0)
Novartis
Cardiology, immunology
Entresto (6.6), Cosentyx (5.2)

AI Investment Snapshot (2025)
Company
AI Highlights (2025)
Scale/Impact
Pfizer
AI cuts discovery from years → 30 days; heavy partnerships
Leader in adoption
AstraZeneca
Evinova AI trials unit; $2.5B AI Beijing hub; 12k+ staff upskilled
Very aggressive (>85% productivity gain)
Merck & Co.
Gen-AI for protocols; 20+ AI “blockbusters” in pipeline
>$1.2B spend
J&J
900+ AI projects → $500M savings; surgical AI training
Broad internal rollout
Roche
AI diagnostics + drug discovery; $55M Manifold Bio deal
Strong in diagnostics
Novartis
AI pipeline acceleration; data-science alliances
Integrated into $10B R&D
Dr. Lev-Ari’s Prompt:
  • AI in biotech startups
Searched for “(“AI” OR “artificial intelligence”) (“biotech” OR “biotechnology”) startup since:2025-01-01″
10 results
Show All (2)

AI in Biotech Startups:

2025 LandscapeArtificial Intelligence (AI) is revolutionizing biotech startups by accelerating drug discovery, optimizing clinical trials, and enabling personalized medicine. In 2025, AI applications like generative models for molecule design and predictive analytics for protein structures are slashing R&D timelines from years to months, reducing costs by up to 30%, and boosting success rates. The sector blends biology’s complexity with AI’s data-crunching power, drawing massive VC interest amid ethical debates on gene editing and biosecurity.Key Trends

  • Explosive Funding Growth: U.S. healthcare VC hit $23B in 2024, with ~30% ($5.6B) targeting AI-biotech—nearly triple 2023 levels. Biopharma startups raised $24.2B across 568 deals, up from $10.1B in 2023. Q3 2025 saw $97B global VC (up 38% YoY), half to AI firms. Mega-rounds ($100M+) surged, focusing on drug discovery and rare diseases.
  • Market Expansion: Global AI-biotech market: $4.6B in 2025, projected to $11.4B by 2030 (20% CAGR). Biotech overall to $5.85T by 2034 (13.6% CAGR), driven by AI in gene editing, microbiome therapeutics, and automation.
  • Compute Demands: Biotech AI requires massive GPUs; Nvidia’s AI sales hit $41.1B in one 2025 quarter (56% YoY). Startups lean on cloud partnerships (e.g., AWS-Recursion) or in-house clusters, with hyperscalers eyeing $3-4T infrastructure by 2030.
  • Regional Hotspots: North America leads (42% share) via FDA support and hubs like Boston/SF; Europe grows via funding/regulatory advances; Asia (e.g., China) via collaborations.
  • Challenges & Ethics: Selective funding favors clinically validated firms; rising M&A (big pharma acquiring AI startups); ethical scrutiny on AI gene editing (e.g., CRISPR enhancements).

 

Notable Startups & Recent Funding

Here’s a snapshot of standout AI-biotech startups, highlighting innovations and 2024-2025 funding:

Startup
Focus Area
Key Innovation
Recent Funding (2025)
Insilico Medicine
Drug Discovery
Generative AI for novel molecules
$100M+ Series D (ongoing)
Recursion Pharmaceuticals
Phenomics & Drug Repurposing
AI mapping diseases via cell images
$50M partnership w/ Nvidia
Absci Corp.
Protein Design
AI-generated antibodies/proteins
$20M from AMD (Jan 2025)
TandemAI
Drug Discovery
ML for molecular simulation
$22M Series A extension
Red Queen Bio
Biosecurity
AI for pathogen detection/design
$15M Seed led by OpenAI
Antiverse
Antibody Design
AI predicting antibody structures
Deal w/ Nxera Pharma (2024)
Deep Genomics
Genomics
AI extracting insights from DNA data
VC round undisclosed
Aizen Therapeutics
Molecule Generation
Proprietary AI engines for trials
Early-stage VC

These firms exemplify AI’s shift from hype to pipeline impact—e.g., Insilico’s AI-discovered drug entered Phase II trials in record time.Emerging ApplicationsAI’s top uses in biotech startups:

  1. Drug Discovery: ML predicts drug-target interactions (e.g., AlphaFold-inspired tools cut screening costs 70%).
  2. Genomics & Diagnostics: AI analyzes vast datasets for rare variants, powering precision oncology.
  3. Clinical Trials: Predictive models optimize patient matching, reducing failures by 20-30%.
  4. Synthetic Biology: AI designs custom microbes for therapeutics or biofuels.
  5. Automation Labs: AI-robotics handle experiments autonomously, boosting throughput 10x.

Future Outlook

2025 signals a “quality over quantity” pivot: Investors prioritize AI startups with real-world data and partnerships (e.g., Y Combinator, Google for Startups). M&A will rise as big pharma (Pfizer, Merck) snaps up talent. Yet, compute shortages and regs (e.g., FDA AI guidelines) pose hurdles. For founders, blending AI with wet-lab validation is key to unlocking the next wave of breakthroughs—potentially curing diseases once deemed untreatable. If you’re building or investing, focus on
  • rare diseases or
  • oncology

for the hottest bets.

Additional Competitors by Product Line

@Grok Response

https://x.com/i/grok/share/Ple3W4IDlwhyjUwBUU4JAg2OD

Key Products and Focus AreasPfizer’s portfolio spans immunology, oncology, cardiology, endocrinology, neurology, and vaccines. In 2024, its top revenue generators included:

  • Eliquis (apixaban, blood thinner): $7.3 billion (11% of total revenue).
  • Prevnar family (pneumococcal vaccines): $6.4 billion (10%).
  • Paxlovid (COVID-19 antiviral): $5.7 billion (9%).
  • Vyndaqel (tafamidis, for rare heart disease): $5.4 billion (8%).
  • Comirnaty (COVID-19 vaccine): $5.3 billion (8%).
  • Ibrance (palbociclib, breast cancer drug): $4.3 billion (6%).

The company is investing heavily in AI-driven drug discovery (e.g., 2024 partnerships with NVIDIA and Saama) and next-gen therapies like RSV vaccines, gene therapies for muscular dystrophy, and oral GLP-1 drugs for obesity/diabetes. Challenges include patent expirations (e.g., Eliquis in 2026-2028) and biosimilar competition, but Pfizer’s diversified pipeline positions it for mid-single-digit growth in 2025.Pfizer’s Main CompetitorsPfizer operates in a highly competitive $1.5 trillion global pharma market, where rivals vie for dominance in oncology, vaccines, immunology, and emerging areas like obesity and gene therapy. Its primary competitors are fellow “Big Pharma” giants, often overlapping in therapeutic areas. Based on revenue, market share, and direct product rivalries, here are the top ones (ranked roughly by 2024 revenue for context):

Competitor
Headquarters
2024 Revenue (Pharma Segment)
Key Strengths & Overlaps with Pfizer
Notable Products
Johnson & Johnson (J&J)
New Brunswick, NJ, USA
$88.8 billion (total; pharma ~$57.8 billion)
Diversified (pharma, devices, consumer); strong in oncology, immunology, vaccines. Competes directly in blood thinners and cancer therapies.
Darzalex (multiple myeloma), Stelara (psoriasis), Imbruvica (blood cancer).
Merck & Co.
Rahway, NJ, USA
$64.2 billion
Oncology leader; vaccines and antivirals. Keytruda outsells Pfizer’s Ibrance; rivals in HPV/pneumococcal vaccines.
Keytruda (immunotherapy, $29.5 billion), Gardasil (HPV vaccine).
Roche Holding AG
Basel, Switzerland
~$68 billion (group; pharma ~$50 billion)
Diagnostics + pharma powerhouse; dominates oncology and neurology. Competes in antibody-drug conjugates post-Pfizer’s Seagen buy.
Ocrevus (MS), Hemlibra (hemophilia), Avastin (cancer).
AbbVie Inc.
North Chicago, IL, USA
$56.3 billion
Immunology and neuroscience focus; biosimilars erode shared markets like Humira vs. Pfizer’s Enbrel alternatives.
Humira (rheumatoid arthritis), Skyrizi (psoriasis), Rinvoq (arthritis).
Novo Nordisk A/S
Bagsværd, Denmark
~$40 billion (est.)
Diabetes/obesity specialist; exploding GLP-1 demand challenges Pfizer’s emerging obesity pipeline.
Ozempic/Wegovy (semaglutide for diabetes/weight loss).
Eli Lilly and Co.
Indianapolis, IN, USA
~$45 billion (est.; projecting $58-61 billion in 2025)
Diabetes/obesity and neurology; Mounjaro rivals Pfizer’s danuglipron in GLP-1 space.
Mounjaro/Zepbound (tirzepatide), Verzenio (breast cancer).
AstraZeneca PLC
Cambridge, UK
$50.95 billion
Oncology, respiratory, and cardiovascular; Tagrisso competes with Pfizer’s Lorbrena in lung cancer.
Tagrisso (lung cancer), Farxiga (diabetes/heart), Imfinzi (immunotherapy).
Novartis AG
Basel, Switzerland
~$48 billion
Gene therapy and immunology; rivals in rare diseases and oncology.
Cosentyx (psoriasis), Entresto (heart failure), Kisqali (breast cancer).
Bristol-Myers Squibb (BMS)
New York, NY, USA
$47.8 billion
Oncology and immunology; Opdivo directly competes with Pfizer’s Bavencio in checkpoint inhibitors.
Opdivo (immunotherapy), Eliquis (co-developed with Pfizer, but BMS handles ex-US).
Sanofi S.A.
Paris, France
~$46 billion
Vaccines and rare diseases; Dupixent challenges in immunology; rivals Prevnar in pneumococcal vaccines.
Dupixent (atopic dermatitis), Lantus (diabetes).

These competitors collectively hold over 50% of the global pharma market share. Emerging threats include biotech upstarts like Moderna (mRNA vaccines, directly rivaling Comirnaty) and generics firms like Teva (eroding post-patent revenues). In 2025, competition intensifies in obesity (Novo/Lilly lead) and oncology (Merck/Roche dominate), with tariffs and pricing pressures (e.g., US executive orders) affecting all.Pfizer’s edge comes from its scale and partnerships (e.g., BioNTech for mRNA), but it must navigate revenue dips from COVID fade-out and biosimilars. For 2025 projections, analysts expect 6-9% growth across the sector, with Pfizer targeting modest gains through oncology expansions. If you’d like deeper dives on specific rivals, financials, or products, let me know!

AI Acquisitions by Big Pharma

2 days ago • Visible to anyone on or off LinkedIn

AI in Pharma: From Tool to Value Creator 🚀

Over the past 5 years, pharma’s AI footprint has expanded rapidly and the investment trends tell a clear story.

💡 ~60% of collaborations and acquisitions now focus on TargetDiscovery and Validation — pharma’s main frontier to shorten early-stage R&D timelines and boost success rates through PrecisionBiology.
⚗️ The second-largest area (~25%) centers on AI-driven DrugDesign and MoleculeOptimization, where algorithms accelerate CandidateSelection, refine molecular properties, and enable NewModalities such as Biologics and CellAndGeneTherapies.
🏆 Among top players, Eli Lilly and Company stands out as the most active investor — making AI a true StrategicCapability, not just another research tool.

The takeaway?
AI isn’t just supporting pharma anymore, it’s reshaping it.

Source: Bita Sehat, PhD, MBA

hashtagai hashtaglifesciences hashtagpharmaceuticals hashtagtechbio hashtagbiotech

table

Article was summarized by @Grok on 11/29/2025
Summary of the Article:
“Authentic Relevance of LPBI Group’s Portfolio of IP as Proprietary Training Data Corpus for AI Initiatives at Big Pharma”
This November 15, 2025, article on PharmaceuticalIntelligence.com (curated by LPBI Group) makes a compelling case for leveraging LPBI’s decade-plus of expert-curated digital IP as a high-fidelity, rights-clean training corpus to supercharge AI-driven innovation in Big Pharma. It contrasts the limitations of generic LLMs (like GPT) with the need for domain-specific, ontologized biomedical data, positioning LPBI’s assets as a “defensible moat” for accelerating R&D in drug discovery, precision medicine, and beyond. The piece blends market analysis of pharma giants with a deep dive into LPBI’s portfolio, emphasizing its multimodal, metadata-rich structure for NLP, knowledge graphs, and fine-tuning SLMs/LLMs.IntroductionThe thesis: In an era where AI investments in pharma (e.g., Eli Lilly’s aggressive funding) focus on slashing R&D timelines by 60%+ in target discovery and 25% in drug design, LPBI’s proprietary corpus—built since 2012 via human curation, digitization, and ontology mapping—offers unmatched authenticity over web-scraped data. It addresses GPT’s biomedical shortcomings (e.g., failing to infer fusion proteins or noncanonical pathways without curated inputs) and highlights LPBI’s foresight in text analysis for generative AI augmentation. A key quote from Data2Discovery: “We are able to improve drug discovery now as well as demonstrating new fast-cycle AI-driven processes that will have a revolutionary impact on drug discovery if fully implemented.”Portfolio OverviewLPBI’s ~9 GB, debt-free, multimodal corpus is privately held, expert-curated (e.g., by Prof. Marcus W. Feldman and Dr. Stephen J. Williams), and ingest-ready for AI pre-training/evaluations. It spans five key asset classes, each with metadata exports, timestamps, crosslinks, and centralized rights for model training:

 

Asset Class
Description & Size
Unique Value Proposition
I: Scientific Articles
6,250+ articles on PharmaceuticalIntelligence.com (~2.5M views); covers genomics, oncology, immunology, etc.
Live ontology, author/role labels, view histories; enables temporal NLP for trend analysis.
II: e-Books
48 bilingual (English/Spanish) volumes in 5 BioMed e-Series (e.g., Series A: Cardiovascular, 6 vols., $515 total; Series E: Patient-Centered, 4 vols., $274); 151,000+ page downloads; 2,728 articles.
Peer-reviewed, senior-editor TOCs; pay-per-view model proves demand; ideal for entity-relationship extraction.
III: e-Proceedings
100+ from biotech/genomics conferences (2013–2025); +50 tweet collections as speaker quotes with affiliations.
Real-time event curation; captures emerging insights for knowledge graph augmentation.
V: Biological Images
7,500+ images in Digital Art Media Gallery; embedded as prior art in texts.
Expert-contextualized visuals; supports multimodal AI for image-text pairing in diagnostics.
X: Audio Podcasts
300+ interviews with scientific leaders (e.g., Nobel laureates like Jennifer Doudna); classified by themes like CRISPR, mRNA vaccines.
Transcripts + NLP WordClouds; adds auditory/verbal depth for voice-enabled AI copilots.

The portfolio’s “living ontology” allows seamless integration into tools like InfraNodus for concept mapping.AI Training RelevanceUnlike PubMed’s unstructured dumps, LPBI’s assets are pre-annotated for concept extraction (e.g., gene-disease-drug dyads), reducing hallucinations and bias in LLMs. A case study integrates curation with ChatGPT-5: Manual ontology + knowledge graphs uncovered novel WNT/Hedgehog interactions in lung cancer, generating research questions like: “How does the interaction between [[EGFR]] mutations and sex-specific gene alterations, including [[RBM10]], influence treatment outcomes in lung adenocarcinoma?” This hybrid approach outperforms solo GPT, proving the corpus’s role in trustworthy biomedical inference.Applications

  • Drug Discovery: ML prompts on dyads to mimic Pfizer’s AI (e.g., reducing discovery from years to months); supports biologics/cell therapies.
  • Precision Medicine: 547 articles for patient subtyping; 3,615 disease-focused pieces for predictive modeling.
  • Diagnostics & Rare Diseases: 560 rare disease articles + 30 on ATTR-CM for early detection (e.g., via Pfizer’s ASPIRE AI).
  • Clinical/Regulatory: Streamlines trials, evidence synthesis, and content generation (e.g., via Pfizer’s “Charlie” copilot, saving hours on lit reviews).
  • Generative Tools: Fine-tune for compliant, domain-aware outputs in medical affairs/safety.

Challenges & Solutions

  • Data Quality/Bias: Unstructured text leads to GPT errors; solved by expert curation + ontology for accurate, diverse inputs.
  • Regulatory Compliance: Rights fragmentation; addressed via LPBI’s centralized assignment for NDA-secure licensing.
  • Scalability: Generic data overload; LPBI’s focused, high-signal corpus enables fast-cycle AI without noise.

Recommendations

Urge Big Pharma (e.g., Pfizer, Merck—table highlights Merck’s $64.2B revenue, Keytruda focus) to acquire the full portfolio for end-to-end knowledge bases, or license under NDA for SLM/LLM training (English/Spanish).
  • Emphasizes “buy the moat” for competitive edge in 2025’s 6–9% sector growth (obesity/oncology hotspots).
Contact: avivalev-ari@alum.berkeley.edu.
Conclusion
LPBI’s corpus isn’t just data—it’s a “scientific revolution enabler,” blending human creativity with AI for transformative pharma impact. Validated on extraction tasks, it’s primed for partnerships, outshining combinatorial predictions with authentic, curated depth. This article builds on prior LPBI mappings (e.g., our podcast TOC summary), reinforcing the portfolio’s strategic fit for AI.
For deeper analysis or related assets, let me know!

Read Full Post »

Real Time Conferecence Coverage: Advancing Precision Medicine Conference Philadelphia PA November 1,2 2024  Deliverables

Curator: Stephen J. Williams, Ph.D.

Below are deliverables in form of real Time conference coverage from the Advancing Precision Medicine Confererence held this year in Philadelphia, PA.  The meeting brought together scientists and clinicians to discuss the challenges faced in implementing genomics and proteomics into precision medicine decision making workflow.  As summarized by a future release at the 2025 ASCO, there are many issues and hindrances to incorporating data obtained from sequencing to make a personalized medicine strategy.  The meeting focused on two main disease states: oncology and cardiovascular however most of  the live meeting notes are from the oncology tract.  In general it was discussed there are three areas which need to be addressed to correctly and more frequently incorporate precision medicine and genomic panel testing into clinical decision making workflow:

  1.  access to testing panels and testing methodology for both doctors and patients
  2. expert interpretation of results including algorithms needed to analyze the data
  3. more education of molecular biology and omics data and methodology in medical school to address knowledge gaps between clinicians and scientists

The issues can be summarized by a JCO report to ASCO in 2022:

 Helen Sadik, PhDDaryl Pritchard, PhD https://orcid.org/0000-0003-2675-0371 dpritchard@personalizedmedicinecoalition.orgDerry-Mae Keeling, BScFrank Policht, PhDPeter Riccelli, PhDGretta Stone, BSKira Finkel, MSPHJeff Schreier, MBA, and Susanne Munksted, MS.  Impact of Clinical Practice Gaps on the Implementation of Personalized Medicine in Advanced Non–Small-Cell Lung Cancer. 2022: JCO Precision Oncology; Volume 6. https://doi.org/10.1200/PO.22.00246

Personalized medicine presents new opportunities for patients with cancer. However, many patients do not receive the most effective personalized treatments because of challenges associated with integrating predictive biomarker testing into clinical care. Patients are lost at various steps along the precision oncology pathway because of operational inefficiencies, limited understanding of biomarker strategies, inappropriate testing result usage, and access barriers. We examine the impact of various clinical practice gaps associated with diagnostic testing-informed personalized medicine strategies on the treatment of advanced non–small-cell lung cancer (aNSCLC).

The authors used a  Diaceutics’ Data Repository, a multisource database including commercial and Medicare claims and laboratory data from over 500,000 patients with non–small-cell lung cancer in the United States. They  analyzed the number of patients with newly diagnosed aNSCLC who could have, but did not, benefit from a personalized treatment. The analysis was focused on identifying the gaps and at which steps during care did gaps existed which precipitated either lack of use of precision medicine testing or incorrect interpretation of results.

Their conclusions were alarming:

Most patients with aNSCLC eligible for precision oncology treatments do not benefit from them because of clinical practice gaps. This finding is likely reflective of similar gaps in other cancer types. An increased understanding of the impact of each practice gap can inform strategies to improve the delivery of precision oncology, helping to fully realize the promise of personalized medicine.

The links to the live meeting notes are given below and collection of tweets follow (please note this meeting did not have a Twitter hashtag)

Real Time Coverage Advancing Precision Medicine Annual Conference, Philadelphia PA November 1,2 2024

https://pharmaceuticalintelligence.com/2024/11/01/real-time-coverage-advancing-precision-medicine-annual-conference-philadelphia-pa-november-12-2024/

Real Time Coverage Morning Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 1 2024

https://pharmaceuticalintelligence.com/2024/11/01/real-time-coverage-morning-session-on-precision-oncology-advancing-precision-medicine-annual-conference-philadelphia-pa-november-1-2024/

Real Time Coverage Afternoon Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 1 2024

https://pharmaceuticalintelligence.com/2024/11/01/real-time-coverage-afternoon-session-on-precision-oncology-advancing-precision-medicine-annual-conference-philadelphia-pa-november-1-2024/ 

Real Time Coverage Morning Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 2 2024

https://pharmaceuticalintelligence.com/2024/11/04/real-time-coverage-morning-session-on-precision-oncology-advancing-precision-medicine-annual-conference-philadelphia-pa-november-2-2024/ 

Tweet Collection

Tweet Collection Advancing Precision Medicine Conference November 1,2 2024 Philadelphia PA

 

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Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Session October 4 2025

Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Session  October 4 2025

Reporter: Stephen J. Williams, PhD

Leaders in Pharmaceutical Business Intellegence will be covering this conference LIVE over X.com at

@pharma_BI

@StephenJWillia2

@AVIVA1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine #WINSYMPO2025

1:40 – 2:30

AI in Precision Medicine

Dr. Ganhui Lan
Dr. Xiaoyan Wang
Dr. Ahmad P. Tafti
Jen Gilburg

Jen Gilburg (moderator)Deputy Secretary of Technology and Entrepreneurship, Dept. of Community and Economic Development, Commonwealth of Pennsylvania

  • AI will help reduce time for drug development especially in early phase of discovery but eventually help in all phases
  • Ganhui: for drug regulators might be more amenable to AI in clinical trials; AI may be used differently by clinicians
  • nonprofit in Philadelphia using AI to repurpose drugs (this site has posted on this and article will be included here)
  • Ganhui: top challenge of AI in Pharma; rapid evolution of AI and have to have core understanding of your needs and dependencies; realistic view of what can be done; AI has to have iterative learning; also huge vertical challenge meaning how can we allign the use of AI through the healthcare vertical layer chain like clinicians, payers, etc.
  • Ganhui sees a challenge for health companies to understand how to use AI in business to technology; AI in AI companies is different need than AI in healthcare companies
  • 95% of AI projects not successful because most projects are very discrete use

2:00-2:20

Building Precision Oncology Infrastructure in Low- and Middle-Income Countries

Razelle Kurzrock, MD

Sewanti Limaye, MD, Director, Medical & Precision Oncology; Director Clinical and Translational Oncology Research, Sir HN Reliance Foundation Hospital & Research Centre, Mumbai, India; Founder, Nova Precision AI; Co-Founder, Iylon Precision Oncology; Co-Chair, Asia Pacific Coalition Against Lung Cancer; Co-Chair,  Asia Pacific Immuno-Oncology; Member,  WIN Consortium

  • globally 60 precision initiatives but there really are because many in small countries
  • three out of five individuals in India die of cancer
  • precision medicine is a must and a hub and spoke model is needed in these places; Italy does this hub and spoke; spokes you enable the small places and bring them into the network so they know how and have access to precision medicine
  • in low income countries the challenge starts with biopsy: then diagnosis and biomarker is issue; then treatment decision a problem as they may not have access to molecular tumor boards
  • prevention is always a difficult task in LMICs (low income)
  • you have ten times more patients in India than in US (triage can be insurmountable)
  • ICGA Foundation: Indian Cancer Genome Atlas
  • in India mutational frequencies vary with geographical borders like EGFR mutations or KRAS mutations
  • genomic landscape of ovarian cancer in India totally different than in TCGA data
  • even different pathways are altered in ovarian cancer seen in North America than in India
  • MAY mean that biomarker panels need to be adjusted based on countries used in
  • the molecular data has to be curated for the India cases to be submitted to a tumor board
  • twenty diagnostic tests in market like TruCheck for Indian market; uses liquid biopsy
  • they are also tailoring diagnostic and treatment for India getting FDA fast track approvals

2:20-2:40

Co-targeting KIT/PDGRFA and Genomic Integrity in Gastrointestinal Stromal Tumors

Razelle Kurzrock, MD

Lori Rink, PhD, Associate ProfessorFox Chase Cancer Center

  • GIST are most common nesychymal tumor in GI tract
  • used to be misdiagnosed; was considered a leimyosarcoma
  • very asymptomatic tumors and not good prognosis
  • very refractory to genotoxic therapies
  • RTK KIT/PDGFRA gain of function mutations
  • Gleevec imatinib for unresectable GIST however vast majority of even responders become resistant to therapy and cancer returns
  • there is a mutation map for hotspot mutations and sensitivity for gleevec
  • however resistance emerged to ripretinib; in ATP binding pocket
  • over treatment get a polyclonal resistance
  • performed a kinome analysis; Wee1 looked like a potential target
  • mouse studies (80 day) showed good efficacy
  • avapiritinib ahs some neurotox and used in PDGFRA mut GIST model which is resistant to imitinib
  • but if use Wee1 inhibitor with TKI can lower dose of avapiritinib
  • cotargeting KIT/PDGFRA and WEE1 increases replicative stress
  • they are using PDX models to test these combinations
  • combination creates genomic instability

 

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Real Time Coverage Morning Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 2 2024

Reporter: Stephen J. Williams, Ph.D.

9:20-9:50

How Can We Close the Clinical Practice Gaps in Precision Medicine?

Susanne Munksted, Diaceutics

Studies are showing that genetic tests are being ordered at a sufficient rate however it appears there are problems in interpretation and developing treatment plans based on omics testing results

 

  • 30 % of patients in past and now currently half of all patients are not being given the proper treatment based on genomic testing results (ASCO)
  • E.g. only 1.5% with NTRK fusions received a NTRK based therapy (this was > 4000 patients receiving wrong therapy)
  • A lung oncologist may only see one patient with NTRK fusion in three years

 

Precision Medicine Practice Gaps

48% of oncologist surveyed  agreed pathologist needs to be more informed and relevant in the decision making process with regard to tests needing to be ordered

95% said need to flip cost issues ; what does it cost not to get a test … i.e. what is the cost of the wrong therapy

We need a new commercialization model for therapeutic development for this new era of “n of one” patient

9:50-10:15

Implementation of a CLIA-based Reverse Phase Protein Array Assay for Precision Oncology Applications: Proteomics and Phosphoproteomics at the Bedside (CME Eligible)

Emanuel Petricoin, George Mason University

There are some tumor markers approved by FDA that cant just be measured by NGS and are correlated with a pathologic complete response

 

  • Many point mutations will have no actionable drug
  • Many alterations are post-genomic meaning there is a post translational component to many prognostic biomarkers
  • Prevalence of point mutation with no actionable mutation is a limit of NGS
  • It is important to look at phospho protein spectrum as a potential biomarker

 

Reverse phase protein proteomic analysis

  • Made into CLIA based array
  • They trained centers around the US on the technology and analysis
  • Basing proteomics or protein markers by traditional IHC requires much antibody validation so if the mass spectrometry field can catch up it would be very powerful
  • With multiple MRM.MS there is too low abundance of phosphoproteins to allow for good detection

 

They  conducted the I-SPY2 trial for breast cancer and determining if phosphoproteins could be a good biomarker panel

  • They found they could predict a HER2 response better than NGS
  • There were patients who were predicted HER2 negative that actually had an activated HER2 signaling pathway by proteomics so NGS must have had a series of false negatives
  • HER2 co phosphorylation predicts pathologic complete response and predicts therapy by herceptin
  • They found patients classified as HER2 negative by FISH were HER2 positive by proteomics and had HER2 activation

10:15-11:10

Liquid Biopsy MRD to Escalate or De-escalate Therapy (CME Eligible)

Adrian Lee

Adrian Lee, UPMC

Marija Balic, UPMC

Howard McLeod

Howard McLeod, Utah Tech University

Muhammed, Murtaza, University of Wisconsin-Madison

 

11:15-11:25  PRODUCT PRESENTATION  204A

SpaceIQ™ – Powering Next Generation Precision Therapeutics with AI-Driven Spatial Biomarkers

Dusty Majumdar, PredxBio 

Single Cell and Spatial Omics

 

  • Single cell transcriptomics technology have been scaled up very nicely over the past ten years
  • Spatial informatics field is lacking in innovations
  • Can get a terabyte worth of data from analysis of one slide

11:25-11:35  PRODUCT PRESENTATION  204C

10x Genomics

11:40-12:35

Transcriptomics and AI in Transforming Precision Diagnosis

Maher Albitar, Genomic Testing Cooperative

Transciptomica and AI:Transforming Precision diagnosis

-The Genomics Testing Coopererative at www.genomictestingcooperative.com

 

Advantages of transcriptomics

– mutation frequency and allele variant detection now at 80% (higher sensitivity in mutation detection)

 

– transcriptomics has good detection of chromosomal translocations

– great surrogate for IHC and detect splicing alterations

– can use AI to predict % of PDL1 in tumor cells versus immune cells

– they have developed a software UMAP (uniform manifold approximation and projection) to supervise cluster analysis

– the group has used AI to predict prognosis and survival using transcriptomics data

Marija Balic, UPMC

Andrew Pecora, Hackensack University Medical Center 

12:35-1:00

The Impact of Multi-Omics in the Context of the APOLLO-2 Moonshot Program (CME Eligible)

 

 

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Coverage Afternoon Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 1 2024

Reporter: Stephen J. Williams, Ph.D.

Unlocking the Next Quantum Leap in Precision Medicine – A Town Hall Discussion (CME Eligible)

Co-Chairs

Amanda Paulovich, Professor, Aven Foundation Endowed Chair
Fred Hutchinson Cancer Center

Susan Monarezm Deputy Director ARPA-H

Henry Rodriguez, NCI/NIH

Eric Schadt, Pathos

Ezra Cohen, Tempus

Jennifer Leib, Innovation Policy Solutions

Nick Seddon, Optum Genomics

Giselle Sholler, Penn State Hershey Children’s Hospital

Janet Woodcock, formerly FDA

Amanda Paulovich: Frustrated by the variability in cancer therapy results.  Decided to help improve cancer diagnostics

  •  We have plateaued on relying on single gene single protein companion diagnostics
  • She considers that regulatory, economic, and cultural factors are hindering the innovation and resulting in the science way ahead of the clinical aspect of diagnostics
  • Diagnostic research is not as well funded as drug discovery
  • Biomarkers, the foundation for the new personalized medicine, should be at forefront Read the Tipping Point by Malcolm Gladwell
  • FDA is constrained by statutory mandates 

 

Eric Schadt

Pathos

 

  • Multiple companies trying to chase different components of precision medicine strategy including all the one involved in AI
  • He is helping companies creating those mindmaps, knowledge graphs, and create more predictive systems
  • Population screening into population groups will be using high dimensional genomic data to determine risk in various population groups however 60% of genomic data has no reported ancestry
  • He founded Sema4 but many of these companies are losing $$ on these genomic diagnostics
  • So the market is not monetizing properly
  • Barriers to progress: arbitrary evidence thresholds for payers, big variation across health care system, regulatory framework

 

Beat Childhood Cancer Consortium Giselle

 

  • Consortium of university doctors in pediatrics
  • They had a molecular tumor board to look at the omics data
  • Showed example of choroid plexus tumor success with multi precision meds vs std chemo
  • Challenges: understanding differences in genomics test (WES, NGS, transcriptome etc.
  • Precision medicine needs to be incorporated in med education.. Fellowships.. Residency
  • She spends hours with the insurance companies providing more and more evidence to justify reimbursements
  • She says getting that evidence is a challenged;  biomedical information needs to be better CURATED

 

Dr. Ezra Cohen, Tempest

 

  • HPV head and neck cancer, good prognosis, can use cituximab and radiation
  • $2 billion investment at Templest of AI driven algorithm to integrate all omics; used LLM models too

Dr. Janet Woodcock

 

  • Our theoretical problem with precision and personalized medicine is that we are trained to think of the average patient
  • ISPAT II trial a baysian trial; COVID was a platform trial
  • She said there should there be NIH sponsored trials on adaptive biomarker platform trials

This event will be covered by the LPBI Group on Twitter.  Follow on

@Pharma_BI

@StephenJWillia2

@Aviva1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine

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Real Time Coverage Morning Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 1 2024

Reporter: Stephen J. Williams, Ph.D.

Notes from Precision Medicine for Rare Diseases 9:00AM – 10:50

Precision Medicine and markers Cure models vs disease models  Dr Ekker from UT MD Anderson

 

  • UT MD Anderson zebrafish disease model program now focusing more on figuring the mechanisms by which a disease model is reverted to normal upon CRISPR screens
  • Traditional drug development process long and expensive
  • 2nd in class only takes 4 years while 3rd in class drugs take only 1.5 years
  • Health-in-a-fish: using a CRE system to go from disease to normal
  • The theory is making a CRE or CURE avatar; taking a diseased zebrafish and reverse engineering the disease genome
  • He used transposon based CRE mutational mutants with protein trap and 3’ exon trap (transposon based mutagenesis)
  • He reverted the diseased gene by CRE
  • He feels that can scale up to using organoids to develop more cure based models

 

FDA Christine Nguyen MD regulatory perspective of framework of drug approval for rare diseases

  • 1 in 10 Amercians have rare diseases; 70% genetic and half are children
  • Due to Orphan Drug Act in 2023 half of novel drugs approved for rare diseases
  • CDER and FDA 550 unique drugs for over 1000 rare diseases
  • Clinical and surrogate validated endpoints are important for traditional approvals
  • For accelerated approval need predictive surrogate endpoint of clinical benefit
  • For accelerated approval needs completion of a confirmatory trials so FDA has new authority under FDORA; FDA can dictate trial milestones
  • Candidate surrogate endpoints: known to predict (validated) for traditional approval but reasonably likely to predict for accelerated approval
  • Does surrogate endpoint associated with a causal pathway?  Also important to understand the magnitude of benefit so surrogate should be quantitative not just qualitative
  • RDEA is a series of 3 public workshops at FY2027 to promote innovation and novel endpoints and guidance

 

Frank Sasinowski FDA regulatory flexibility beyond One Positive Adequate and Well Controlled Trial

  •  As we move to rare diseases we may only have one well controlled study so FDA feels we need new regulatory frameworks and guidelines especially for rare disease clinical trails especially with precision medicine
  • Accelerated approval does not mean your evidence is any less stringent that traditional approval (only difference is endpoint but quality of evidence the same)

 

  • Confirmatory evidence is a primary concern
  • In 2021 FDA coordinated with the two divisions CBER and CDER
  • Sometimes a primary endpoint shows positive benefit but secondary endpoints may not; FDA now feels that results from one well designed AWC gives confirmatory evidence
  • FDA can be flexible by taking in consideration the quantity and quality of confirmatory evidence and the totality of evidence
  • So pharmacology studies, natural history etc.  can be enough
  • For a drug like Lamzede for mannosidosis there were no positive endpoint studies or for ADA SCID disease there was other compelling evidence
  • The FDA does have flexibility when it comes to advanced precision medicines and ultr rare diseases

10:50 Do we Really Need Liquid Biopsy? A Panel Discussion on the Issues Hampering the full Adoption of Liquid Biopsy

  • In Mexico leading cancer is colorectal but only have the FIT test and noone except one organization who issupplying health access
  • Access to precision medicine is a concern:  the communication between the patient, who is pushing this more than healthcare, needs to be coordinated better with all stakeholders in care
  • We also need to educate many physicians even oncologists (like in Virginia) a better understanding of genetics and omics
  • FT3 consortium does testing to therapy (multistakeholder group comprised of patient advocacy groups); focus on amplifying global efforts to increase access; they are trying to make a roadmap to help access in other countries; when it comes to precision medicine it is usually the nurses that are aksing for training because they are usually the first responders for the patient’s questions
  • In rural areas just getting access to liquid biopsy is a concern and maybe satellite sites might be useful because the time to schedule is getting worse (like 3 or more months)
  •  A recent paper showed that liquid biopsy may actually perpetuate health disparities and not ameliorate them
  • BloodPAC: there are barriers to LB access and adoption so consortium felt that there were many areas that need to be addressed: financial, access, disparities, education
  • ctDNA to define variants was the past focus; there is growing realization that there are representatives populations in your R&D studies
  • Submission of data to BloodPac is easier to do for tissue not for liquid biopsy;  there is lack of harmonization across many of these databanks
  • Reimbursement: is a barrier to access for liquid biopsy
  • Illumina: challenge finding clinical utility for payers; FDA approval is not as hard; show improved outcomes for patients; Medicare is starting to approve some tests but the criteria bar keeps changing with payers; 
  • How do we leverage the on-market data to support performance of your diagnostic test or genomic panel

 

This event will be covered by the LPBI Group on Twitter.  Follow on

@Pharma_BI

@StephenJWillia2

@Aviva1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine

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The Health Care Dossier on Clarivate PLC: How Cortellis Is Changing the Life Sciences Industry

Curator: Stephen J. Williams, Ph.D.

Source: https://en.wikipedia.org/wiki/Clarivate 

Clarivate Plc is a British-American publicly traded analytics company that operates a collection of subscription-based services, in the areas of bibliometrics and scientometricsbusiness / market intelligence, and competitive profiling for pharmacy and biotechpatents, and regulatory compliancetrademark protection, and domain and brand protection. In the academy and the scientific community, Clarivate is known for being the company that calculates the impact factor,[4] using data from its Web of Science product family, that also includes services/applications such as PublonsEndNoteEndNote Click, and ScholarOne. Its other product families are Cortellis, DRG, CPA Global, Derwent, MarkMonitor, CompuMark, and Darts-ip, [3] and also the various ProQuest products and services.

Clarivate was formed in 2016, following the acquisition of Thomson Reuters‘ Intellectual Property and Science business by Onex Corporation and Baring Private Equity Asia. Clarivate has acquired various companies since then, including, notably, ProQuest in 2021.

Further information: Thomson Scientific

Clarivate (formerly CPA Global) was formerly the Intellectual Property and Science division of Thomson Reuters. Before 2008, it was known as Thomson Scientific. In 2016, Thomson Reuters struck a $3.55 billion deal in which they spun it off as an independent company, and sold it to private-equity firms Onex Corporation and Baring Private Equity Asia.

In May 2019, Clarivate merged with the Churchill Capital Corp SPAC to obtain a public listing on the New York Stock Exchange (NYSE) It currently trades with symbol NYSE:CLVT.

Acquisitions

  • June 1, 2017: Publons, a platform for researchers to share recognition for peer review.
  • April 10, 2018: Kopernio, AI-tech startup providing ability to search for full-text versions of selected scientific journal articles.
  • October 30, 2018: TrademarkVision, provider of Artificial Intelligence (AI) trademark research applications.
  • September 9, 2019: SequenceBase, provider of patent sequence information and search technology to the biotech, pharmaceutical and chemical industries.
  • December 2, 2019: Darts-ip, provider of case law data and analytics for intellectual property (IP) professionals.
  • January 17, 2020: Decision Resources Group (DRG), a leading healthcare research and consulting company, providing high-value healthcare industry analysis and insights.
  • June 22, 2020: CustomersFirst Now, in intellectual property (“IP”) software and tech-enabled services.
  • October 1, 2020: CPA Global, intellectual property (“IP”) software and tech-enabled services.
  • December 1, 2021: ProQuest, software, data and analytics provider to academic, research and national institutions.[27]It was acquired for $5.3 billion from Cambridge Information Group in what was described as a “huge deal in the library and information publishing world”. The company said that the operational concept behind the acquisition was integrating ProQuest’s products and applications with Web of Science. Chairman of ProQuest Andy Snyder became the vice chairman of Clarivate. The Scholarly Publishing and Academic Resources Coalition, an advocacy group for open access to scholarship, voiced antitrust concerns. The acquisition had been delayed mid-year due to a Federal Trade Commission antitrust probe.

Divestments

How Clarivate Has Changed Since 2019

2019 Strategy

From 2019 Manager Discussion Yearly Report

We are a leading global information services and analytics company serving the scientific research, intellectual property and life sciences end-markets. We provide structured information and analytics to facilitate the discovery, protection and commercialization of scientific research, innovations and brands.  Our product porfolio includes well-established market-leading brands such as Web of Science, Derwent Innovation, Life Sciences, CompuMark and MarkMonitor (which they later divested).  We believe that the stron balue proposition of our content, user interfaces, visualization and analytical tools, combined with the integration of our products and services into customers’ daily workflows, leads to our substantial customer loyalty as evidenced by their willingness to renew subscriptions with us.

Our structure, enabling a sharp focus on cross-selling opportunities within markets, is comprised of two product groups:

  • Science Group: consists of Web of Science and Life Science Product Lines
  • Intellectual Property Group: consists of Derwent, CompuMark and MarkMonitor

Corporations, government agencies, universities, law firms depend on our high-value curated content, analytics and services.  Unstructured data has grown exponentially over the last decade.  The trend has resulted in a critical need for unstructured data to be meaningfully filtered, analyzed and curated into relvent information that facilitates key operational and strategic decision making.  Our highly curated, proprietary information created through our sourcing, aggregation, verification, translation, and categorization (ONTOLOGY) of data has resulted in our solutions being embedded in our customers’ workflow and decision-making processes.

Overview of Clarivate PLC five year strategy in 2019. Note that in 2019 the Science Group accounted for 56.2% of revenue! This was driven by their product Cortellis!

Figure.  Overview of Clarivate PLC five year strategy in 2019. Note that in 2019 the Science Group accounted for 56.2% of revenue! This was driven by their product Cortellis!

Also Note nowhere in the M&A Discussion in years before 2023 was anything mentioned concerning AI or Large Language Models.

The Clarivate of Today:  Built for Life Sciences with Cortellis

Clarivate PLC has integrated multiple platforms into their offering Cortellis, which integrated AI and LLM into the structured knowledge bases (see more at https://clarivate.com/products/cortellis-family/)

“Life sciences organizations are tasked, now more than ever, to discover and develop treatments that challenge the status quo, increase ROI, and improve patient lives. However, its become increasingly difficult to find, integrate and analyze the key data your teams need to make critical decisions and get your Cortellis products to patients faster.

The Cortellis solutions help research and developmentportfolio strategy and business development, and regulatory and compliance professionals gather and assess the information you need to discover innovative drugs, differentiate your treatments, and increase chances of successful regulatory approval.

Some of Cortellis solutions include:

  1. Cortellis Competitive Intelligence: maximize ROI and improve patient outcomes
  2. Cortellis Deals Intelligence: Portfolio Strategy and Business Development (find best deal)
  3. Cortellis Clinical Intelligence: Clinical Trial Support and Regulatory
  4. Cortellis Digital Health Intelligence: understand digital health ecosystem
  5. Cortellis Drug Discovery: improve drug development speed and efficiency
  6. MetaBase and MetaCore: integrated omics knowledge bases for drug discovery
  7. Cortellis Regulatory: help with filings
  8. Cortellis HTA: health tech compliance (HIPAA)
  9. CMC Intelligence: new drug marketing
  10. Generics Intelligence
  11. Drug Safety Intelligence: both preclinical safety and post marketing pharmacovigilence

Watch Videos on Cortellis for Drug Discovery

Watch Video on Qiagen Site to see how Cortellis Integrates with Qiagen Omics Platform IPA with Clarivate Meta Core to gain more insights into genomic and proteomic data

https://digitalinsights.qiagen.com/products-overview/discovery-insights-portfolio/analysis-and-visualization/qiagen-ipa/?cmpid=QDI_GA_Comp&gad_source=2&gclid=EAIaIQobChMIwu6HtvHGhQMVnZ9aBR1iCgHTEAEYASAAEgJiWPD_BwE

From the Qiagen website on Ingenuity Pathway Analysis: https://digitalinsights.qiagen.com/products-overview/discovery-insights-portfolio/analysis-and-visualization/qiagen-ipa/ 

Understand complex ‘omics data to accelerate your research

Discover why QIAGEN Ingenuity Pathway Analysis (IPA) is the leading pathway analysis application among the life science research community and is cited in tens of thousands of articles for the analysis, integration and interpretation of data derived from ‘omics experiments. Such experiments include:

  • RNA-seq
  • Small RNA-seq
  • Metabolomics
  • Proteomics
  • Microarrays including miRNA and SNP
  • Small-scale experiments

With QIAGEN IPA you can predict downstream effects and identify new targets or candidate biomarkers. QIAGEN Ingenuity Pathway Analysis helps you perform insightful data analysis and interpretation to understand your experimental results within the context of various biological systems.

Articles Relevant to Drug Development, Natural Language Processing in Drug Development, and Clarivate on this Open Access Scientific Journal Include:

The Use of ChatGPT in the World of BioInformatics and Cancer Research and Development of BioGPT by MIT

From High-Throughput Assay to Systems Biology: New Tools for Drug Discovery

Medical Startups – Artificial Intelligence (AI) Startups in Healthcare

New York Academy of Sciences Symposium: The New Wave of AI in Healthcare 2024. May 1-2, 2024 New York City, NY

Clarivate Analytics – a Powerhouse in IP assets and in Pharmaceuticals Informercials

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Live Notes from JP Morgan Healthcare Conference Virtual Endpoints Preview: January 8-9 2024

Reporter: Stephen J. Williams, Ph.D.

Endpoints at #JPM24 | Primed to unlock biopharma’s next dealmaking wave
Endpoints at JP Morgan Healthcare Conference
January 8-9 | San Francisco, CA80 Mission St, San Francisco, CA

An oasis has emerged in the biopharma money desert as backers look to replenish capital — still, uncertainty remains on whether it’s a mirage or the much needed dealmaking bump the industry needs. Yet spirits run high as JPM24 marks the triumphant return of inking strategic alliances and peering into the industry crystal ball — while keeping an eye out for some major M&A.

We’re back live from San Francisco for JPM Monday and Tuesday — our calendar of can’t-miss panels and fireside chats will feature prominent biopharma leaders to watch. The Endpoints Hub provides the ultimate coworking space with everything you need — 1:1 and group meeting spots plus guest pass capabilities and more. Join us in-person at the Endpoints Hub or watch online to stay plugged into all the action.

8 JAN
Welcome remarks
8:05 AM – 8:25 AM PST
Pfizer vet Mikael Dolsten has some thoughts on Big Pharma R&D

Endpoints News founding editor John Carroll will sit down with longtime Pfizer CSO Mikael Dolsten to talk about Pfizer’s pipeline, what he’s learned on the job about preclinical research and development and what’s ahead for the pharma giant in drug development and deals.

Mikael Dolsten

Chief Scientific Officer, President, Pfizer Research & Development

Pfizer

Pfizer Mikael Dolsten: Pfizer produced a series of AI generated molecules with new properties. Sees rapid adoption of AI in the area of drug discovery and molecular design.

 
 
8:25 AM – 9:05 AM PST
What pharma wants: The industry’s dealmakers look ahead at 2024

The drug industry’s appetite for new assets hasn’t slowed down. Top business development execs will give their outlook on the year, what they’re looking for and how they see the market.

Glenn Hunzinger

Pharmaceutical & Life Sciences Consulting Solutions Leader

PwC US

Rachna Khosla

SVP, Head of Business Development

Amgen

James Sabry

Global Head of Pharma Partnering

Roche

Devang Bhuva

SVP, Corporate Development

Gilead Sciences, Inc.

Endpoints News

Dealmaking panel

Glenn Hunzinger: if you do not have a GLP1 will have a tough time getting a good market price for your company; capital markets are not where they want to be; sees a tough deal making climate like last year.  The problem with many biotech companies are they are coming earlier to the venture capital because of greater funding needs and so it is imperative that they articulate the potential of their company in scientific detail

Rachna Khosla:  Make sure your investors are not just CAPITAL PARTNERS but use their expertise and involve them in development issues you may have, especially ones that a young firm will face.  The problem is most investments assume what the future looks like (for example how antibody drug conjugates, once a field left for dead, has been rejuvenated because of advances in chemistry). 

James Sabry: noted that cardiac and metabolic drugs are now at the focus of many investors, especially with the new anti-obesity drugs on market

Devang Bhuva: Most deals we see start as collaborations or partnerships.  You want to involve an alliance management team early in the deal making process.  This process could take years.

 
9:05 AM – 9:20 AM PST
The IPO: How Apogee Therapeutics went public in the most challenging market in years

Not many biotechs went public in 2023. And of those that did, not many have had a great time of it. Apogee is the exception and our panel will offer a behind-the-scenes look at their decision to enter the market and what life is like as a young public company.

Michael Henderson

CEO

Apogee Therapeutics

Kyle LaHucik

MODERATOR

Senior Reporter

Endpoints News

Michael Henderson:  Not many biotech IPOs deals happened in 2023.  Michael feels it is because too many biotechs focused on building platforms, which was a hard sell in 2023.  He felt not many biotechs had clear milestones and investors wanted a clear primary validated target.  He said many biotech startups are in a funding crunch and most need at least $440M on their balance sheet to get to 2026.

9:50 AM – 10:10 AM PST
Top predictions for biotech in 2024

Catalent CEO Alessandro Maselli will be back at the big JPM healthcare confab to talk with Endpoints News founder John Carroll about their top predictions of what’s coming up for the biotech industry in 2024. The stakes couldn’t be higher as the industry grapples with headwinds and new opportunities in a gale of market forces. Two top observers share their thoughts on the year ahead.

Alessandro Maselli

President & CEO

Catalent

10:15 AM – 10:35 AM PST
Innovation at a crossroads: Keys to unlocking the value of science and technology

The industry has long discussed the promise of technology and the acceleration it provides in scientific advancement and across the industry value chain. However, the promise of its impact has yet to fully be realized. This discussion will outline the keys to unleashing this promise and the implications and actions to be taken by the biopharmaceutical companies across the industry.

Ray Pressburger

North America Life Sciences Industry Lead & Global Life Sciences Strategy Lead

Accenture

SPONSORED BY

10:35 AM – 11:05 AM PST
Activism and Investing: In conversation with Elliott Investment Management’s Marc Steinberg

Elliott has been behind many of 2023’s highest-profile healthcare investments, including multiple activist engagements and taking Syneos Health private. What has made large healthcare companies such interesting investment opportunities for firms like Elliott? What’s Elliott’s investing strategy in healthcare? And what should companies expect when an activist calls?

Marc Steinberg

Senior Portfolio Manager

Elliott Investment Management

Andrew Dunn

MODERATOR

Biopharma Correspondent

Endpoints News

11:05 AM – 11:35 AM PST
Creating ROI from AI

AI is predicted to transform the way drugs are made, from discovery to clinical trials to market. But beyond the initial hype and early adoption, where has AI made meaningful contributions to R&D? How does it help drug developers advance science? Endpoints publisher Arsalan Arif is convening a panel of leading experts to discuss the state of AI in the pharmaceutical landscape and the outlook for 2024. How does AI impact the drug pipeline, from the early steps of discovery to reducing trial failure rate?

Thomas Clozel

Co-Founder & CEO

Owkin

Venkat Sethuraman

SVP, Global Biometrics & Data Sciences

Bristol Myers Squibb

Frank O. Nestle

Global Head of Research & Chief Scientific Officer

Sanofi

Matthias Evers

Chief Business Officer

Evotec

Arsalan Arif

MODERATOR

Founder & Publisher

Endpoints News

SPONSORED BY

11:35 AM – 12:00 PM PST
Biopharma’s dealmaker: Behind the scenes with Centerview Partners co-president Eric Tokat

Almost every major biopharma deal in 2023 had Centerview’s name attached to it. And much of the time, Eric Tokat was the banker making those deals happen. Hear his outlook for 2024, how transactions are getting done and what’s placed his firm at the center of so much action.

E. Eric Tokat

Co-President, Investment Banking

Centerview Partners

CenterView Partners Eric Tokat feels dealmaking will improve in 2024, given the recent flurry of dealmaking at end of last year and right before main JPM Healthcare Conference.  He says Centerview wants to help the biotechs they invest in on their strategic path.  This may translate into buyers more actively involved (more than startups want) and buyers now are in the drivers seat as far as the timeline of deals and development.

Is the megamerger dead for this year?  He says it is very hard to see two major mergers happening but there will be many smaller and mid size biotech deals happening, but these deals will be more speculative in nature..  The focus for large pharma is top line growth.  Most of the buyers have an infrastructure and value is more of buying and dropping it in their business so there is now a huge emphasis on due diligence on whether synergies exist or not

 
12:00 PM – 12:30 PM PST
Founder, legend, leader: In conversation with Nobel laureate Carolyn Bertozzi

Carolyn Bertozzi’s discoveries around bioorthogonal chemistry won the Nobel Prize in Chemistry in 2022 and are at the heart of new therapies being tested in patients. Join us as we discuss what inspires her and where she sees the next big advances.

Carolyn Bertozzi

Prof. of Chemistry, Stanford University and Baker Family Director of Sarafan ChEM-H

Stanford University

Nicole DeFeudis

MODERATOR

Editor

Endpoints News

Bioorthogonal chemistry: class of high yielding chemical reactions that proceed rapidly and selectively in biological environments without side reactions toward endogenous functions.  This is also a type of ‘click chemistry’ in biological system where only specifically alter the biomolecule of interest.

Orthogonal: two chemicals not interacting with each other

Dr. Bertozzi noted she has started a new Antibody-Drug-Conjugate (ADC) company which involves designing with biorthogonal chemistry to make new functional molecules with varying properties

She noted hardly any biologists knew anything about glycobiology when she first started.  However now she feels pharma and academia are working very well with each other

Bioorthogonal and Click Chemistry
Curated by Prof. Carolyn R. Bertozzi, 2022 winner of the Nobel Prize in Chemistry

Source: https://pubs.acs.org/page/vi/bioorthogonal-click-chemistry

The 2022 Nobel Prize in Chemistry has been awarded jointly to ACS Central Science Editor-in-Chief, Carolyn R. Bertozzi of Stanford University, Morten Meldal of the University of Copenhagen, and K. Barry Sharpless of Scripps Research, for the development of click chemistry and bioorthogonal chemistry.

To celebrate this remarkable achievement, 2022 Nobel Prize winner Professor Carolyn R. Bertozzi has curated this Bioorthogonal and Click Chemistry Virtual Issue, highlighting papers published across ACS journals that have built upon the foundational work in this exciting area of chemistry.

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

Ellen M. Sletten and Carolyn R. Bertozzi* Acc. Chem. Res. 2011, 44, 9, 666-676 August 15, 2011

Abstract

Bioorthogonal reactions are chemical reactions that neither interact with nor interfere with a biological system. The participating functional groups must be inert to biological moieties, must selectively reactive with each other under biocompatible conditions, and, for in vivo applications, must be nontoxic to cells and organisms. Additionally, it is helpful if one reactive group is small and therefore minimally perturbing of a biomolecule into which it has been introduced either chemically or biosynthetically. Examples from the past decade suggest that a promising strategy for bioorthogonal reaction development begins with an analysis of functional group and reactivity space outside those defined by nature. Issues such as stability of reactants and products (particularly in water), kinetics, and unwanted side reactivity with biofunctionalities must be addressed, ideally guided by detailed mechanistic studies. Finally, the reaction must be tested in a variety of environments, escalating from aqueous media to biomolecule solutions to cultured cells and, for the most optimized transformations, to live organisms.

9 JAN

9:40 AM – 10:10 AM PST

Biotech downturn survival school

Our panelists have seen the worst, and made it through to the other side. Join us for downturn survival school as our panelists talk about what sets apart the ones who make it through tough times.

These panalists think it will be specialist capital year to shine while the general capital is still sitting on the sidelines

JJ Kang

CEO

Appia Bio

“2023 was a tough year while 2020 was a boon year to start a company.  We will continue to see these cycles; many of these new CEOs have never seen a biotech downturn yet and may not know how to preserve capital for the downturn”.

“Doing a partnership with Kite Pharmaceuticals early in our startp allowed us to get work done without risking a lot of capital, even if it means equity and asset dilution.  That makes sense. However even if you are small insist on being an equal partner.”

“There are many investors we talk to who do not want to invest in cell therapy.  Too risky now”

Carl Gordon

Managing Partner

OrbiMed Advisors

There are many macroeconomic factors affecting investment and capital today which will carry on through 2024.   Not raising money when you do not need money is a bad philosophy.  Always bbe raising captial.  This is especially true when you have to rely on hedge funds.  Parnerships howeve are sometimes the only way for small biotechs to leverage their strengths.

Joshua Boger

Executive Chair

Alkeus Pharmaceuticals, Inc.

Boger: Expect volatility for 2024.  This environment feels very different than past downturns.

Even in downturns there is still lots of capital; remember access to human capital is better in a downturn and is easier to access;  however it has become harder to get drug approvals

The panelists agree that access to capital and funding will be as tricky in 2024 than 2023.  They did

suggest that a new funding avenue, private credit, may be a source of capital.  This is discussed below:

When thinking about a private alternative investment asset class, the first thing that springs to mind is private equity. But there’s one more asset class with the word private in its name that has recently gained much attention. We’re talking about private credit

Indeed, this once little-known investment strategy is now growing rapidly in popularity, offering private investors worldwide an exciting opportunity to diversify their portfolio with, in theory, less risky investments that yield significant returns. 

  • Private credit investments refer to investors lending money to companies who then repay the loan at a given interest rate within the predetermined period.
  • The private credit market has grown significantly over the past years, rising from $875 million in 2020 to $1.4 trillion at the beginning of 2023. 

Please WATCH VIDEO BY GOLDMAN SACHS ON PRIVATE CREDIT

 

 

 

 

10:50 AM – 11:20 AM PST

The New Molecule: How breakthrough technologies are actually changing pharma R&D

Join us for a look at how AI, machine learning and generative technologies are actually being applied inside drugmakers’ labs. We’ll explore how new technologies are being used, their implications, how they intersect with regulatory and IP issues and how this fast-changing field is likely to evolve.

Kailash Swarna

Managing Director & Global Life Sciences Clinical Development Lead

Accenture

Artificial Intelligence is making impact in a grand way on biology in three aspects:

  1. Speeding up target validation: now we can get through 300 molecules a day
  2. Predicition like AlphaFold is doing; molecular simulations
  3. Document submission especially with regulatory and IND submissions

Pamela Carroll

COO

Isomorphic Labs formerly of AlphaFold

We were first with Novartis at last year JPM and was one year old but parnering with them in that initial year was very important for sealing the deal.

They are looking now at neurologic diseases like ALS.  She wondered whether ALS is actually multiple diseases and we need to stratify patients like we do in oncology trials.  Their main competion is the whole tech world like Amazon, Google and other Machine Learning companies so being a tech player in the biotech world means you are not just competing with other biotechs but large tech companies as well.

Jorge Conde

General Partner

Andreessen Horowitz

Need is still great for drug discovery; early adopters show AI tools can be used in big pharma. There are lots of applications of AI in managing care; a lot of back office applications including patient triaging.  He does not see big AI mergers with pharma companies –  this will be mainly partnerships not M&A deals

Alicyn Campbell

Chief Scientific Officer

Evinova, a Healthtech Subsidiary of the AstraZeneca Group

There is a need to turn AI for real world example.  For example AI tools were used in clinical trials to determine patient cohorts with pneumonitis.  At Evinova they are determining how AI can hel[p show clinical benefit with respect to efficacy and safety

Joshua Boger at #JPM24 (Brian Benton Photography)

  January 12, 2024 09:06 AM ESTUpdated 10:00 AM PeopleStartups

Vertex founder Joshua Boger on surviving downturns, ‘painful’ partnerships, and the importance of culture: #JPM24

Andrew Dunn

Biopharma Correspondent

Source: https://endpts.com/jpm24-vertex-founder-joshua-boger-on-surviving-downturns-painful-partnerships-and-the-importance-of-culture/

While the JP Morgan Healthcare Conference was full of voices of measured optimism, rooting for the market to bounce back in 2024, one longtime biotech leader warned against setting any firm expectations.

Instead of predicting when the downturn may end, Vertex Pharmaceuticals founder Joshua Boger said he advises biotech leaders to expect — and plan for — volatility. Speaking Tuesday on an Endpoints News panel alongside OrbiMed’s Carl Gordon and Appia Bio CEO JJ Kang, Boger shared lessons learned on surviving downturns, striking pharma deals, and the importance of keeping a company’s culture based on his two decades of founding and leading Vertex as CEO from 1989 to 2009. The 72-year-old is now serving as executive chairman of Alkeus Pharmaceuticals, a startup developing a rare disease drug.

“I never experienced a straight line up,” Boger said. “Everything had its cycles, and it was how you respond to the cycle, not by predicting when the end is going to be, but just by responding to the present situation.”

At Boger’s first appearance at the JP Morgan conference in 1991, he said the conference’s theme was the end of biotech financing. Just a few months later, Regeneron successfully went public, rapidly changing the outlook for the whole field.

“We had no idea we were ever going to take public money,” he said. “When Regeneron did their IPO, we went, ‘Whoa, there’s something happening here,’ and we pivoted quickly.”

Vertex went public later that year. Throughout his 20-year tenure, Boger said no pharma company ever made an acquisition offer for Vertex, which now commands a market value of $110 billion and recently won the first FDA approval for a CRISPR gene editing therapy.

“We had an uber corporate policy to always make ourselves more expensive than anyone would stomach,” Boger said.

However, Vertex did strike a range of partnerships with Big Pharmas, which Boger described as a painful but necessary part of running a biotech startup.

“It’s impossible for a partnership not to slow you down,” he said. “You can and should try as hard as you can not to do that, but just count on it. They’ll slow you down.”

Boger said startups should insist on being equal partners in pharma deals, at least making sure they have a seat at a partner’s development meetings.

“Realize they’re going to be painful, it’s going to be horrible, and you need to do it,” Boger said.

While Vertex suffered through layoffs, stock price plunges, and trial failures, Boger credited a focus on culture as key to its long-term success.

“It’s the most important ingredient for a successful company,” he said. “Technology is acquirable. Culture is not acquirable. There are 10 companies that will fail because of culture for every one that succeeds, and the successful companies in retrospect will almost always have special cultural aspects that kept them through those downtimes.”

JPM24 opens with ADCs the hottest ticket in San Francisco

By Annalee ArmstrongJan 8, 2024 6:30am

Source: https://www.fiercebiotech.com/biotech/jpm24-opens-adcs-hottest-ticket-san-francisco

The overall deal flow in biopharma tapered off in 2023 but the big companies sure know what they want (what they really, really want), according to a new report from J.P. Morgan.

And that’s antibody-drug conjugates, which drove a fourth-quarter spike in licensing deal proceeds and provided a glimmer of hope to an industry battered by outside forces and grim financing prospects.

J.P. Morgan’s annual 2023 Biopharma Licensing and Venture Report arrived on the eve of the firm’s famous conference, which is set to welcome thousands of attendees in San Francisco today—East Coast weather permitting.

2023 was tough, but clinical biotechs still had a lot of opportunities to wheel and deal, according to J.P. Morgan. While licensing deals, venture investments, M&A and IPOs were down overall in the fourth quarter, deal values stayed fairly high thanks to a flurry of late-stage tie ups.

Follow the Fierce team’s coverage of the 2024 J.P. Morgan Healthcare Conference here

Biopharma licensing partnerships accounted for $63 billion in total value during the fourth quarter from 108 deals. Just one deal—Merck’s ADC partnership with Daiichi Sankyo—accounted for $22 billion of that. Another huge one was another ADC bet, with Bristol Myers Squibb signing on to work with SystImmune for a total value of $8.4 billion. If you exclude the Merck deal, the total value of these partnerships is still higher than the previous quarter, which ended with $32.1 billion.

The total number of licensing deals compares to 149 in the same quarter a year earlier, 195 for Q4 2021 and 223 for Q4 2022.

As for venture investments, the year closed out with $17 billion total across 250 rounds, thanks to $3.5 billion earned through 79 rounds in the last quarter. Aiolos Bio snagged the title of largest venture round of the quarter with $245 million, which also proved to be the largest series A, too.

There was just one IPO in all of the fourth quarter—Cargo Therapeutics making the plunge for $300 million—and 13 overall for the year. It’s a far cry from the heyday of 2021 and experts are still unsure what 2024 will hold. J.P. Morgan reported $2.5 billion raised from 12 completed biopharma IPOs for the year on Nasdaq and NYSE. Nine out of the 12 companies had clinical programs when they took the leap to the public markets. As of December 13, five of the companies were trading above their IPO price.

As for M&A, December saw a rush of Big Pharmas snapping up companies around Christmas. J.P. Morgan tallied the fourth quarter at $37.6 billion and $128.8 billion across 112 total acquisitions for all of 2023.

AbbVie was the top buyer of the quarter with the two largest acquisitions thanks to the $10 billion outlay for ImmunoGen and $8.7 billion buy of Cerevel Therapeutics.

All of this adds up to 270 total deals in the fourth quarter total, which is lower than the third quarter which exceeded 300.

J.P. Morgan sees some big potential for smaller biopharmas looking for licensing partners, as Big Pharmas have been handing out larger upfront payments for the deals they really want.

Cancer was once again the most in-demand therapeutic areas, reaching a new height of $86.1 billion in 2023. Followed by $21.1 billion for neurological disorders.

For More Articles on Real Time Conference Coverage in this Open Access Scientific Journal see:

Part One: The Process of Real Time Coverage using Social Media

Part Two: List of BioTech Conferences 2013 to Present

https://worldmedicalinnovation.org/

https://pharmaceuticalintelligence.com/2022/05/01/2022-world-medical-innovation-forum-gene-cell-therapy-may-2-4-2022-boston-in-person/

 

https://event.technologyreview.com/emtech-digital-2022/agenda-overview

 

Read Full Post »

Revolutionizing Business with Apple Vision Pro: The Ultimate Tool for Enhanced Visual Communication

Reporter: Frason Francis Kalapurackal, BE

Image Source: https://www.trustedreviews.com/versus/apple-vision-pro-vs-meta-quest-3-4333959

In today’s fast-paced business world, effective visual communication is more important than ever. This is where Apple Vision Pro comes in, serving as the ultimate tool for enhancing visual communication in the workplace. With its innovative software solution, it revolutionizes the way businesses communicate by providing new and improved methods for creating, editing, and sharing visual content. Apple Vision Pro boasts a user-friendly interface and advanced features that have made it an indispensable asset for businesses seeking to streamline their visual communication processes and boost productivity. The software empowers businesses to generate professional-looking visuals that are easily shareable and foster collaboration, making it an invaluable tool for staying ahead in today’s competitive landscape.

Apple Vision Pro sets itself apart with cutting-edge features such as augmented reality and machine learning, enabling users to create immersive and informative content. Through this tool, businesses can effortlessly produce and distribute videos, presentations, and other visual materials, making it a must-have for business owners, marketers, and creative professionals alike.

The impact of Apple Vision Pro is transformative, revolutionizing how businesses communicate visually. With its advanced capabilities and intuitive interface, it empowers users to craft visually stunning content that not only captivates but also educates. The tool offers a diverse range of visual elements like charts, graphs, images, and videos, enabling the effective conveyance of complex information to audiences. Furthermore, Apple Vision Pro facilitates real-time collaboration, making it easier for teams to work together, generate content collectively, and share ideas seamlessly. These capabilities enable businesses to enhance their visual communication efforts and create more impactful content, ultimately driving them towards achieving their goals with greater efficiency and effectiveness.

Some of the potential applications of Apple Vision Pro:

  1. Gaming: Vision Pro could be used for gaming by providing a more immersive experience.
  2. Productivity: Vision Pro could be used for productivity applications by providing a more natural way to interact with computers.
  3. Creative applications: Vision Pro could be used for creative applications by providing a more immersive way to create and edit content.
  4. Education: Vision Pro could be used for education by providing a more immersive way to learn.
  5. Training: Vision Pro could be used for training by providing a more immersive way to learn new skills.
  6. Remote collaboration: Vision Pro could be used for remote collaboration by providing a more immersive way to work with others.

Source Link:

https://www.forbes.com/sites/traceyfollows/2023/06/15/apple-vision-pro-signals-another-move-into-digital-identity-for-apple/?sh=36a7cf9b63d8

https://hbr.org/2023/06/what-is-apples-vision-pro-really-for

https://www.zdnet.com/article/apples-vision-pro-a-concept-prototype-with-this-enormous-potential/

https://www.core77.com/posts/123826/What-are-the-Actual-Applications-for-Apples-Vision-Pro-Goggles

Other related articles published in this Open Access Online Scientific Journal include the following:

3 articles in the Category:

‘Wearable Tech + Digital Health’ 

https://pharmaceuticalintelligence.com/category/wearable-tech-digital-health/

Read Full Post »

The Use of ChatGPT in the World of BioInformatics and Cancer Research and Development of BioGPT by MIT

Curator: Stephen J. Williams, Ph.D.

Chatbots are being used in multiple interdisciplanary areas in research and medicine and so it was a natural progression to incorporate artificial intelligence (AI), natural language processing (NLP), and chatbot technology like ChatGPT into bioinformatic analysis.

“In domains like informatics, management and marketing, media and communication science, languages and philosophy, psychology and sociology, engineering, design, and human-computer interaction, the fast expanding body of chatbot study is clearly interdisciplinary.

The field of bioinformatics is a natural fit for incorporting this technology.  The curated information below shows some use examples of this technology in bioinformatics related to cancer research.

The text in this reference source was actually generated by ChatGPT (https://chat.openai.com/chat)

Source: https://omicstutorials.com/using-chatgpt-in-bioinformatics-and-biomedical-research/

How ChatGPT can be used in bioinformatics research?
ChatGPT is a variant of the GPT (Generative Pre-trained Transformer) language model that was designed to generate human-like text in a conversational setting. It is not directly related to bioinformatics, which is the field of study that deals with the storage, retrieval, and analysis of biological data, particularly in the context of genetics and genomics. However, ChatGPT could potentially be used in a bioinformatics context as a tool for generating natural language descriptions of genetic or genomic data, or for generating responses to queries about such data.

For example, a researcher could use ChatGPT to generate descriptions of genetic variants or gene expression patterns based on input data. This could be useful for generating summaries of results for reports or papers, or for generating explanations of complex concepts for non-expert audiences. ChatGPT could also be used to generate responses to queries about genetic or genomic data, such as “What is the function of gene X?” or “What are the potential consequences of variant Y?”

It’s worth noting that ChatGPT is just one of many tools and techniques that can be used in bioinformatics, and it is unlikely to be the most suitable or effective option in every situation. There are many specialized tools and resources available for working with biological data, and it is often necessary to use a combination of these tools to fully analyze and understand the data.

Generating descriptions of genetic or genomic data: ChatGPT could be used to generate natural language descriptions of genetic or genomic data based on input data. For example, suppose a researcher has a dataset containing information about gene expression levels in different tissues. The researcher could use ChatGPT to generate a description of the data, such as:
“Gene X is highly expressed in the liver and kidney, with moderate expression in the brain and heart. Gene Y, on the other hand, shows low expression in all tissues except for the lung, where it is highly expressed.”

 

Thereby ChatGPT, at its simplest level, could be used to ask general questions like “What is the function of gene product X?” and a ChatGPT could give a reasonable response without the scientist having to browse through even highly curated databases lie GeneCards or UniProt or GenBank.  Or even “What are potential interactors of Gene X, validated by yeast two hybrid?” without even going to the curated InterActome databases or using expensive software like Genie.

Summarizing results: ChatGPT could be used to generate summaries of results from genetic or genomic studies. For example, a researcher might use ChatGPT to generate a summary of a study that found a association between a particular genetic variant and a particular disease. The summary might look something like this:
“Our study found that individuals with the variant form of gene X are more likely to develop disease Y. Further analysis revealed that this variant is associated with changes in gene expression that may contribute to the development of the disease.”

It’s worth noting that ChatGPT is just one tool that could potentially be used in these types of applications, and it is likely to be most effective when used in combination with other bioinformatics tools and resources. For example, a researcher might use ChatGPT to generate a summary of results, but would also need to use other tools to analyze the data and confirm the findings.

ChatGPT is a variant of the GPT (Generative Pre-training Transformer) language model that is designed for open-domain conversation. It is not specifically designed for generating descriptions of genetic variants or gene expression patterns, but it can potentially be used for this purpose if you provide it with a sufficient amount of relevant training data and fine-tune it appropriately.

To use ChatGPT to generate descriptions of genetic variants or gene expression patterns, you would first need to obtain a large dataset of examples of descriptions of genetic variants or gene expression patterns. You could use this dataset to fine-tune the ChatGPT model on the task of generating descriptions of genetic variants or gene expression patterns.

Here’s an example of how you might use ChatGPT to generate a description of a genetic variant:

First, you would need to pre-process your dataset of descriptions of genetic variants to prepare it for use with ChatGPT. This might involve splitting the descriptions into individual sentences or phrases, and encoding them using a suitable natural language processing (NLP) library or tool.

Next, you would need to fine-tune the ChatGPT model on the task of generating descriptions of genetic variants. This could involve using a tool like Hugging Face’s Transformers library to load the ChatGPT model and your pre-processed dataset, and then training the model on the task of generating descriptions of genetic variants using an appropriate optimization algorithm.

Once the model has been fine-tuned, you can use it to generate descriptions of genetic variants by providing it with a prompt or seed text and asking it to generate a response. For example, you might provide the model with the prompt “Generate a description of a genetic variant associated with increased risk of breast cancer,” and ask it to generate a response. The model should then generate a description of a genetic variant that is associated with increased risk of breast cancer.

It’s worth noting that generating high-quality descriptions of genetic variants or gene expression patterns is a challenging task, and it may be difficult to achieve good results using a language model like ChatGPT without a large amount of relevant training data and careful fine-tuning.

 

To train a language model like chatGPT to extract information about specific genes or diseases from research papers, you would need to follow these steps:

Gather a large dataset of research papers that contain information about the specific genes or diseases you are interested in. This dataset should be diverse and representative of the types of papers you want the model to be able to extract information from.

Preprocess the text data in the research papers by tokenizing the text and creating a vocabulary. You may also want to consider lemmatizing or stemming the text to reduce the dimensionality of the dataset.

Train the language model on the preprocessed text data. You may want to fine-tune a pre-trained model such as chatGPT on your specific dataset, or you can train a new model from scratch.

ChatGPT could also be useful for sequence analysis

A few examples of sequence analysis a ChatGPT could be useful include:

  1. Protein structure
  2. Identifying functional regions of a protein
  3. Predicting protein-protein interactions
  4. Identifying protein homologs
  5. Generating Protein alignments

All this could be done without having access to UNIX servers or proprietary software or knowing GCG coding

ChatGPT in biomedical research
There are several potential ways that ChatGPT or other natural language processing (NLP) models could be applied in biomedical research:

Text summarization: ChatGPT or other NLP models could be used to summarize large amounts of text, such as research papers or clinical notes, in order to extract key information and insights more quickly.

Data extraction: ChatGPT or other NLP models could be used to extract structured data from unstructured text sources, such as research papers or clinical notes. For example, the model could be trained to extract information about specific genes or diseases from research papers, and then used to create a database of this information for further analysis.

Literature review: ChatGPT or other NLP models could be used to assist with literature review tasks, such as identifying relevant papers, extracting key information from papers, or summarizing the main findings of a group of papers.

Predictive modeling: ChatGPT or other NLP models could be used to build predictive models based on large amounts of text data, such as electronic health records or research papers. For example, the model could be trained to predict the likelihood of a patient developing a particular disease based on their medical history and other factors.

It’s worth noting that while NLP models like ChatGPT have the potential to be useful tools in biomedical research, they are only as good as the data they are trained on, and it is important to carefully evaluate the quality and reliability of any results generated by these models.

 

ChatGPT in text mining of biomedical data
ChatGPT could potentially be used for text mining in the biomedical field in a number of ways. Here are a few examples:

Extracting information from scientific papers: ChatGPT could be trained on a large dataset of scientific papers in the biomedical field, and then used to extract specific pieces of information from these papers, such as the names of compounds, their structures, and their potential uses.

Generating summaries of scientific papers: ChatGPT could be used to generate concise summaries of scientific papers in the biomedical field, highlighting the main findings and implications of the research.

Identifying trends and patterns in scientific literature: ChatGPT could be used to analyze large datasets of scientific papers in the biomedical field and identify trends and patterns in the data, such as emerging areas of research or common themes among different papers.

Generating questions for further research: ChatGPT could be used to suggest questions for further research in the biomedical field based on existing scientific literature, by identifying gaps in current knowledge or areas where further investigation is needed.

Generating hypotheses for scientific experiments: ChatGPT could be used to generate hypotheses for scientific experiments in the biomedical field based on existing scientific literature and data, by identifying potential relationships or associations that could be tested in future research.

 

PLEASE WATCH VIDEO

 

In this video, a bioinformatician describes the ways he uses ChatGPT to increase his productivity in writing bioinformatic code and conducting bioinformatic analyses.

He describes a series of uses of ChatGPT in his day to day work as a bioinformatian:

  1. Using ChatGPT as a search engine: He finds more useful and relevant search results than a standard Google or Yahoo search.  This saves time as one does not have to pour through multiple pages to find information.  However, a caveat is ChatGPT does NOT return sources, as highlighted in previous postings on this page.  This feature of ChatGPT is probably why Microsoft bought OpenAI in order to incorporate ChatGPT in their Bing search engine, as well as Office Suite programs

 

  1. ChatGPT to help with coding projects: Bioinformaticians will spend multiple hours searching for and altering open access available code in order to run certain function like determining the G/C content of DNA (although there are many UNIX based code that has already been established for these purposes). One can use ChatGPT to find such a code and then assist in debugging that code for any flaws

 

  1. ChatGPT to document and add coding comments: When writing code it is useful to add comments periodically to assist other users to determine how the code works and also how the program flow works as well, including returned variables.

 

One of the comments was interesting and directed one to use BIOGPT instead of ChatGPT

 

@tzvi7989

1 month ago (edited)

0:54 oh dear. You cannot use chatgpt like that in Bioinformatics as it is rn without double checking the info from it. You should be using biogpt instead for paper summarisation. ChatGPT goes for human-like responses over precise information recal. It is quite good for debugging though and automating boring awkward scripts

So what is BIOGPT?

BioGPT https://github.com/microsoft/BioGPT

 

The BioGPT model was proposed in BioGPT: generative pre-trained transformer for biomedical text generation and mining by Renqian Luo, Liai Sun, Yingce Xia, Tao Qin, Sheng Zhang, Hoifung Poon and Tie-Yan Liu. BioGPT is a domain-specific generative pre-trained Transformer language model for biomedical text generation and mining. BioGPT follows the Transformer language model backbone, and is pre-trained on 15M PubMed abstracts from scratch.

The abstract from the paper is the following:

Pre-trained language models have attracted increasing attention in the biomedical domain, inspired by their great success in the general natural language domain. Among the two main branches of pre-trained language models in the general language domain, i.e. BERT (and its variants) and GPT (and its variants), the first one has been extensively studied in the biomedical domain, such as BioBERT and PubMedBERT. While they have achieved great success on a variety of discriminative downstream biomedical tasks, the lack of generation ability constrains their application scope. In this paper, we propose BioGPT, a domain-specific generative Transformer language model pre-trained on large-scale biomedical literature. We evaluate BioGPT on six biomedical natural language processing tasks and demonstrate that our model outperforms previous models on most tasks. Especially, we get 44.98%, 38.42% and 40.76% F1 score on BC5CDR, KD-DTI and DDI end-to-end relation extraction tasks, respectively, and 78.2% accuracy on PubMedQA, creating a new record. Our case study on text generation further demonstrates the advantage of BioGPT on biomedical literature to generate fluent descriptions for biomedical terms.

Tips:

  • BioGPT is a model with absolute position embeddings so it’s usually advised to pad the inputs on the right rather than the left.
  • BioGPT was trained with a causal language modeling (CLM) objective and is therefore powerful at predicting the next token in a sequence. Leveraging this feature allows BioGPT to generate syntactically coherent text as it can be observed in the run_generation.py example script.
  • The model can take the past_key_values (for PyTorch) as input, which is the previously computed key/value attention pairs. Using this (past_key_values or past) value prevents the model from re-computing pre-computed values in the context of text generation. For PyTorch, see past_key_values argument of the BioGptForCausalLM.forward() method for more information on its usage.

This model was contributed by kamalkraj. The original code can be found here.

 

This repository contains the implementation of BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining, by Renqian Luo, Liai Sun, Yingce Xia, Tao Qin, Sheng Zhang, Hoifung Poon and Tie-Yan Liu. BioGPT is a github which is being developed by MIT in collaboration with Microsoft. It is based on Python.

License

BioGPT is MIT-licensed. The license applies to the pre-trained models as well.

Contributing

This project welcomes contributions and suggestions. Most contributions require you to agree to a Contributor License Agreement (CLA) declaring that you have the right to, and actually do, grant us the rights to use your contribution. For details, visit https://cla.opensource.microsoft.com.

When you submit a pull request, a CLA bot will automatically determine whether you need to provide a CLA and decorate the PR appropriately (e.g., status check, comment). Simply follow the instructions provided by the bot. You will only need to do this once across all repos using our CLA.

This project has adopted the Microsoft Open Source Code of Conduct. For more information see the Code of Conduct FAQ or contact opencode@microsoft.com with any additional questions or comments.

As of right now this does not seem Open Access, however a sign up is required!

We provide our pre-trained BioGPT model checkpoints along with fine-tuned checkpoints for downstream tasks, available both through URL download as well as through the Hugging Face 🤗 Hub.

Model Description URL 🤗 Hub
BioGPT Pre-trained BioGPT model checkpoint link link
BioGPT-Large Pre-trained BioGPT-Large model checkpoint link link
BioGPT-QA-PubMedQA-BioGPT Fine-tuned BioGPT for question answering task on PubMedQA link
BioGPT-QA-PubMedQA-BioGPT-Large Fine-tuned BioGPT-Large for question answering task on PubMedQA link
BioGPT-RE-BC5CDR Fine-tuned BioGPT for relation extraction task on BC5CDR link
BioGPT-RE-DDI Fine-tuned BioGPT for relation extraction task on DDI link
BioGPT-RE-DTI Fine-tuned BioGPT for relation extraction task on KD-DTI link
BioGPT-DC-HoC Fine-tuned BioGPT for document classification task on HoC link

 

So far as to date (6/12/2023) there are three papers referencing BioGPT on PubMed (abstracts and links below)

 

BioGPT: generative pre-trained transformer for biomedical text generation and mining.

Luo R, Sun L, Xia Y, Qin T, Zhang S, Poon H, Liu TY.Brief Bioinform. 2022 Nov 19;23(6):bbac409. doi: 10.1093/bib/bbac409.PMID: 36156661

We evaluate BioGPT on six biomedical natural language processing tasks and demonstrate that our model outperforms previous models on most tasks. …Our case study on text generation further demonstrates the advantage of BioGPT on biomedical literature to generate fl …

Here they show the advantages of BioGPT over BioBERT and ChatGPT in an example of text extraction and question answer

Table 7. Example of generated text

Input                                           Model                 Text

Bicalutamide                               GPT-2                 Bicalutamide, a synthetic bicalutamide derivative, was found to increase the cellular proliferation

of C. elegans cells. This effect was not observed with the other synthetic bicalutamide derivatives. This is in line with our previous work which showed that bicalutamide increases the proliferation of C. elegans cells but not in the presence of synthetic bicalutamide.

BioGPT             Bicalutamide (Casodex) is an androgen receptor (AR) antagonist approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients who have progressed on or are ineligible for docetaxel chemotherapy, as well as for the treatment of early-stage prostate cancer in men who have not progressed on or are ineligible for docetaxel chemotherapy, as well as for the treatment of metastatic castration-sensitive prostate cancer (mCSPC) in men who have not progressed on or are ineligible for docetaxel chemotherapy.

Janus kinase 3 (JAK-3)                 GPT-2               Janus kinase 3 (JAK-3) mediates the conversion of glucose to glycogen in skeletal muscle. The
increase in glucose uptake by skeletal muscle is believed to be associated with a reduction in muscle protein breakdown and with the release of ketone bodies, which contribute to the metabolism of glucose.

BioGPT             Janus kinase 3 (JAK-3) is a member of the Janus kinase (JAK) family of non-receptor tyrosine kinases and plays an important role in the regulation of cell proliferation, differentiation, survival, migration and angiogenesis.

Apricitabine                                 GPT-2               Apricitabine, duloxetine and citalopram) were investigated in patients with a history of
treatment-resistant depression (n = 10). We found that treatment with the three drugs significantly decreased depressive symptoms, but not depressive symptoms over the next 12 weeks. We conclude that antidepressant drugs that reduce depressive symptoms and reduce depressive symptoms over time may be beneficial in patients with recurrent depression.

BioGPT             Apricitabine is an oral prodrug of 5-aza-2 ’-deoxycytidine (5-aza-CdR), a DNA methyltransferase (DNMT) inhibitor, which has been approved by the US Food and Drug Administration (FDA) for the treatment of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in combination with low-dose cytarabine (Ara-C) and granulocyte colony-stimulating factor (G-CSF) for patients with intermediate-2 or high-risk MDS or AML.

Xylazine                                      GPT-2               Xylazine, the ‘active ingredient’ in ‘bath salts’ (see above) has been linked to numerous deaths,
including those of former University of California, Berkeley, professor Andrew Anglin, who posted

a video of himself having a bath filled with it.

BioGPT             Xylazine is an alpha 2-adrenoceptor agonist which has been used as a sedative and analgesic in veterinary medicine for many years, but its effects on the cardiovascular system have not been extensively studied in the dog, and its effects on the central nervous system (CNS) have not been well characterized in the dog, despite the fact that xylazine has been widely used as a sedative and analgesic in veterinary medicine for more than 30 years.

Psoralen                                      GPT-2               Psoralen, the city of the spiritualist, and had been given to him by God, who wished to show him
the way of salvation, and to draw him back to the true life of Christ, and to bring him into communion with his fellow-man.

BioGPT             Psoralen photochemotherapy (PUVA) is a well-established treatment for psoriasis, but its use is limited by the risk of skin cancer, particularly squamous cell carcinoma (SCC) of the head and neck (H & N), which is the most common site of skin cancer in the United States (US)

CP-673451                                  GPT-2                 CP-673451) and 4-5-6-3-1-2-3-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-

28-29-30-31-32-33-34-35-36-37-38-39-40-41-42-43-44-45-46-47-48-49-50…

BioGPT             CP-673451 is a potent, selective, and orally active inhibitor of human neutrophil elastase (HNE) and human cathepsin G (CatG) with in vitro and in vivo anti-inflammatory activity in a variety of animal models of inflammation and in a model of acute lung injury (ALI) in the rat induced by intratracheal instillation of lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha), a model of acute lung injury (ALI) in which neutrophils play an important role.

BIIB-021                                     GPT-2               BIIB-021A-2-1.pdf. Wright, C. (2002). ‘The War on Terror: A Legal Theory of Terrorist Attacks,’ in
L.E.R. Wright, S.R. Warrick and J.H. Rothman (Eds.), The War on Terror: Essays in Honor of Michael T. Klare (New York: Oxford University Press), 143-57.

BioGPT             BIIB-021 is a novel, orally active, non-peptide bradykinin B2 receptor antagonist with potent and long-lasting anti-inflammatory activity in animal models of acute and chronic inflammation and in a rat model of adjuvant-induced arthritis (AIA), an animal model of rheumatoid arthritis (RA) and in a rat model of collagen-induced arthritis (CIA), an animal model of collagen-induced arthritis (CIA), in which arthritis is induced by immunization with bovine type II collagen (CII).

Note how BioGPT is more descriptive and accurate!

EGFI: drug-drug interaction extraction and generation with fusion of enriched entity and sentence information.

Huang L, Lin J, Li X, Song L, Zheng Z, Wong KC.Brief Bioinform. 2022 Jan 17;23(1):bbab451. doi: 10.1093/bib/bbab451.PMID: 34791012

The rapid growth in literature accumulates diverse and yet comprehensive biomedical knowledge hidden to be mined such as drug interactions. However, it is difficult to extract the heterogeneous knowledge to retrieve or even discover the latest and novel knowledge in an efficient manner. To address such a problem, we propose EGFI for extracting and consolidating drug interactions from large-scale medical literature text data. Specifically, EGFI consists of two parts: classification and generation. In the classification part, EGFI encompasses the language model BioBERT which has been comprehensively pretrained on biomedical corpus. In particular, we propose the multihead self-attention mechanism and packed BiGRU to fuse multiple semantic information for rigorous context modeling. In the generation part, EGFI utilizes another pretrained language model BioGPT-2 where the generation sentences are selected based on filtering rules.

Results: We evaluated the classification part on ‘DDIs 2013’ dataset and ‘DTIs’ dataset, achieving the F1 scores of 0.842 and 0.720 respectively. Moreover, we applied the classification part to distinguish high-quality generated sentences and verified with the existing growth truth to confirm the filtered sentences. The generated sentences that are not recorded in DrugBank and DDIs 2013 dataset demonstrated the potential of EGFI to identify novel drug relationships.

Availability: Source code are publicly available at https://github.com/Layne-Huang/EGFI.

 

GeneGPT: Augmenting Large Language Models with Domain Tools for Improved Access to Biomedical Information.

Jin Q, Yang Y, Chen Q, Lu Z.ArXiv. 2023 May 16:arXiv:2304.09667v3. Preprint.PMID: 37131884 Free PMC article.

While large language models (LLMs) have been successfully applied to various tasks, they still face challenges with hallucinations. Augmenting LLMs with domain-specific tools such as database utilities can facilitate easier and more precise access to specialized knowledge. In this paper, we present GeneGPT, a novel method for teaching LLMs to use the Web APIs of the National Center for Biotechnology Information (NCBI) for answering genomics questions. Specifically, we prompt Codex to solve the GeneTuring tests with NCBI Web APIs by in-context learning and an augmented decoding algorithm that can detect and execute API calls. Experimental results show that GeneGPT achieves state-of-the-art performance on eight tasks in the GeneTuring benchmark with an average score of 0.83, largely surpassing retrieval-augmented LLMs such as the new Bing (0.44), biomedical LLMs such as BioMedLM (0.08) and BioGPT (0.04), as well as GPT-3 (0.16) and ChatGPT (0.12). Our further analyses suggest that: (1) API demonstrations have good cross-task generalizability and are more useful than documentations for in-context learning; (2) GeneGPT can generalize to longer chains of API calls and answer multi-hop questions in GeneHop, a novel dataset introduced in this work; (3) Different types of errors are enriched in different tasks, providing valuable insights for future improvements.

PLEASE WATCH THE FOLLOWING VIDEOS ON BIOGPT

This one entitled

Microsoft’s BioGPT Shows Promise as the Best Biomedical NLP

 

gives a good general description of this new MIT/Microsoft project and its usefullness in scanning 15 million articles on PubMed while returning ChatGPT like answers.

 

Please note one of the comments which is VERY IMPORTANT


@rufus9322

2 months ago

bioGPT is difficult for non-developers to use, and Microsoft researchers seem to default that all users are proficient in Python and ML.

 

Much like Microsoft Azure it seems this BioGPT is meant for developers who have advanced programming skill.  Seems odd then to be paying programmers multiK salaries when one or two Key Opinion Leaders from the medical field might suffice but I would be sure Microsoft will figure this out.

 

ALSO VIEW VIDEO

 

 

This is a talk from Microsoft on BioGPT

 

Other Relevant Articles on Natural Language Processing in BioInformatics, Healthcare and ChatGPT for Medicine on this Open Access Scientific Journal Include

Medicine with GPT-4 & ChatGPT
Explanation on “Results of Medical Text Analysis with Natural Language Processing (NLP) presented in LPBI Group’s NEW GENRE Edition: NLP” on Genomics content, standalone volume in Series B and NLP on Cancer content as Part B New Genre Volume 1 in Series C

Proposal for New e-Book Architecture: Bi-Lingual eTOCs, English & Spanish with NLP and Deep Learning results of Medical Text Analysis – Phase 1: six volumes

From High-Throughput Assay to Systems Biology: New Tools for Drug Discovery

Machine Learning (ML) in cancer prognosis prediction helps the researcher to identify multiple known as well as candidate cancer diver genes

 

20 articles in Natural Language Processing

142 articles in BioIT: BioInformatics

111 articles in BioIT: BioInformatics, NGS, Clinical & Translational, Pharmaceutical R&D Informatics, Clinical Genomics, Cancer Informatics

 

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