Leaders in Pharmaceutical Business Intelligence (LPBI) Group

WordCloud Visualization of LPBI’s Top Sixteen Articles on CANCER in eight categories and by Views at All Time and their Research Categories in the Ontology of PharmaceuticalIntelligence.com

Curator: Stephen J. Williams, PhD and WordCloud Producers: Daniel Menzin, Noam Steiner-Tomer, Zach Day, Ofer Markman, PhD and Aviva Lev-Ari, PhD, RN

Introduction (From Cancer Volume 1): Cancer is the second most cause of medically related deaths in the developed world.  However, concerted efforts among most developed nations to eradicate the disease, such as increased government funding for cancer research and a mandated ‘war on cancer’ in the mid 70’s has translated into remarkable improvements in diagnosis, early detection, and cancer survival rates for many individual cancer.  For example, survival rate for breast and colon cancer have improved dramatically over the last 40 years.  In the UK, overall median survival times have improved from one year in 1972 to 5.8 years for patients diagnosed in 2007.  In the US, the overall 5 year survival improved from 50% for all adult cancers and 62% for childhood cancer  in 1972 to 68% and childhood cancer rate improved to 82% in 2007. However, for some cancers, including lung, brain, pancreatic and ovarian cancer, there has been little improvement in survival rates since the “war on cancer” has started.

Many of the improvements in survival rates are a direct result of the massive increase in the knowledge of tumor biology obtained through ardent basic research.  Breakthrough discoveries regarding oncogenes, cancer cell signaling, survival, and regulated death mechanisms, tumor immunology, genetics and molecular biology, biomarker research, and now nanotechnology and imaging, have directly led to the advances we now we in early detection, chemotherapy, personalized medicine, as well as new therapeutic modalities such as cancer vaccines and immunotherapies and combination chemotherapies.  Molecular and personalized therapies such as trastuzumab and aromatase inhibitors for breast cancer, imatnib for CML and GIST related tumors, bevacizumab for advanced colorectal cancer have been a direct result of molecular discoveries into the nature of cancer.

Purpose:  To Curate a listing of articles in CANCER representative of  the Agora of the LPBI Journal for the purpose of generating WordClouds for eventual Natural Language Processing.

Methods:

For a full description of methodology please contact the LPBI Group at avivalev-ari@alum.berkeley.edu , LinkedIn, or through Twitter @pharma_BI.

Methods in Brief:

 A listing of all Cancer articles which had been viewed at least 131 times was generated.  They could either be authored, curated, written, or reported articles.  The initial list was generated by Daniel, Chief Technology Officer.  This listing was generated as an Excel worksheet.  (A Total of 1555 articles had views of at least 133 total all time views of which 352 were explicitly on Cancer.  Each article was read and verified for cancer-related content).

Each Cancer article was then categorized  according to the STYLE in which it was written as follows

• • Authored; requires original thought, ideas, and multiple references; has a methodology
  • Curated; multiple disparate sources connected by a theme generated by the curator
  • Written: as a writer; only one or two references but having some input into content
  • Reported: an article which only reports on a topic or event; usually a new report or press announcement

After categorizing the STYLE,  the AUTHORED, CURATED, AND WRITTEN articles (263 articles) were further sub-categorized based on the following subject material categories:

• • Therapeutic 
  • Diagnosis 
  • Imaging 
  • Mechanisms of tumorigenesis 
  • Genomics 
  • Resistance and Adverse Events 
  • Patient Care and Personalized Care 
  • Cancer Models and Research 

Each article author or curated was also recorded in the Excel spreadsheet.  A mind map of each of the major authors and curators on the topic of Cancer was generated by curating common themes in the articles as well as opinion pieces written by each of the main editors of the Cancer Volumes (I and II).  The mind-map guided the further selection of 16 articles which were representative of the above sub-categories and reflective of the editor(s) theory of cancer etiology and vision of paradigm changes within the field.  WordClouds were generated from these listing of 16 representative articles of the Agora of Cancer offerings within the LPBI database.

INTERNS PLEASE PUT SOME METHODOLOGY ON HOW YOU GENERATED THE WORDCLOUD

Results:

Article Selection and Categorization

Of the 352 CANCER articles, there were 69 AUTHORED, 178 CURATED, 16 WRITTEN, and 89 REPORTED articles. Sub-categorization of the Authored, Curated, and Written articles yielded the following 

• • Therapeutic (69 articles)
  • Diagnosis (36 articles)
  • Imaging (16 articles)
  • Mechanisms of tumorigenesis (40 articles)
  • Genomics (69 articles)
  • Resistance and Adverse Events (12 articles)
  • Patient Care and Personalized Care (12 articles)
  • Cancer Models and Research (12 articles)

This resulted in 263 article which were either authored, curated or written.  These 263 articles were then used for further sub-selection based on  the Mind Map generated (as described below). 

Generation of a Mind Map of Editors of Cancer Volume 1 and 2

In the Vision of Dr. Larry H. Bernstein:

A multidisciplinary approach has led us to a unique multidisciplinary or systems view of cancer, with different fields of study offering their unique expertise, contributions, and viewpoints on the etiology of cancer.  Diverse fields in immunology, biology, biochemistry, toxicology, molecular biology, virology, mathematics, social activism and policy, and engineering have made such important contributions to our understanding of cancer, that without cooperation among these diverse fields our knowledge of cancer would never had evolved as it has.

 

In the Vision of Dr. Stephen J. Williams

This ebook highlights some of the recent trends and discoveries in cancer research and cancer treatment, with particular attention how new technological and informatics advancements have ushered in paradigm shifts in how we think about, diagnose, and treat cancer.  The book is organized with the 8 hallmarks of cancer in mind, concepts which are governing principles of cancer from Drs. Hanahan and Weinberg (Hallmarks of Cancer).

Maintaining Proliferative Signals

Avoiding Immune Destruction

Evading Growth Suppressors

Resisting Cell Death

Becoming Immortal

Angiogenesis

Deregulating Cellular Energy

Activating Invasion and Metastasis

Therefore the reader is asked to understand how each of these underlying principles are being translated to current breakthrough discoveries, in association with the basic biological knowledge we have amassed through diligent research and how these principals and latest research can be used by the next generation of cancer scientist and oncologist to provide the future breakthroughs.  As the past basic research had provided a new platform for the era of genomics in oncology, it is up to this next generation of scientists and oncologists to provide the basic research for the next platform which will create the future breakthroughs to combat this still deadly disease.

In the Vision of Dr. Dror Nir

The concept of personalized medicine has been around for many years. Recent advances in cancer treatment choice, availability of treatment modalities, including “adaptable” drugs and the fact that patients’ awareness increases, put medical practitioners under pressure to better clinical assessment of this disease prior to treatment decision and quantitative reporting of treatment outcome. In practice, this translates into growing demand for accurate, noninvasive, nonuser-dependent probes for cancer detection and localization. The advent of medical-imaging technologies such as image-fusion, functional-imaging and noninvasive tissue characterisation is playing an imperative role in answering this demand thus transforming the concept of personalized medicine in cancer into practice. The leading modality in that respect is medical imaging. To date, the main imaging systems that can provide reasonable level of cancer detection and localization are: CT, mammography, Multi-Sequence MRI, PET/CT and ultrasound. All of these require skilled operators and experienced imaging interpreters in order to deliver what is required at a reasonable level. It is generally agreed by radiologists and oncologists that in order to provide a comprehensive work-flow that complies with the principles of personalized medicine, future cancer patients’ management will heavily rely on computerized image interpretation applications that will extract from images in a standardized manner measurable imaging biomarkers leading to better clinical assessment of cancer patients.

 

Using these VISIONS of CANCER a mind map was generated for each of these authors/editors. Mind maps consisted of a thematic sentence to describe their individual VISION of CANCER and a second sentence describing what each author/editor saw as greatest PARADIGM SHIFT in their respective sub-disciplines of cancer (basic and clinical).  The MIND MAP is shown below:

 

Category	Article name	Intern Name
Therapeutic (69 articles)	Targeting the Wnt Pathway [7.11]   https://pharmaceuticalintelligence.com/2015/04/10/targeting-the-wnt-pathway-7-11/	Noam
Therapeutic (69 articles)	Warburg Effect and Mitochondrial Regulation- 2.1.3	Daniel
Therapeutic (69 articles)	Cancer Mutations Across the Landscape	Daniel
Therapeutic (69 articles)
Diagnosis (36 articles)	Targeting Cancer Neoantigens and Metabolic Change in T-cells   https://pharmaceuticalintelligence.com/2016/05/19/targeting-cancer-neoantigens-and-metabolic-change-in-t-cells/	Noam
Diagnosis (36 articles)	In Search of Clarity on Prostate Cancer Screening, Post-Surgical Followup, and Prediction of Long Term Remission	Daniel
Diagnosis (36 articles)
Imaging (16 articles)	State of the art in oncologic imaging of Prostate   https://pharmaceuticalintelligence.com/2013/01/28/state-of-the-art-in-oncologic-imaging-of-prostate/	Noam
Imaging (16 articles)
Mechanisms of tumorigenesis (40 articles)	Neuroblastoma: A review   https://pharmaceuticalintelligence.com/2013/06/01/neuroblastoma-a-review/	Noam
Mechanisms of tumorigenesis (40 articles)	Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?	Daniel
Mechanisms of tumorigenesis (40 articles)	How Mobile Elements in “Junk DNA Promote Cancer – Part 1: Transposon-mediated Tumorigenesis”	Daniel
Mechanisms of tumorigenesis (40 articles)
Genomics (69 articles)	Akt inhibition for cancer treatment, where do we stand today?	Daniel
Genomics (69 articles)	Thymosin alpha1 and melanoma	Daniel
Genomics (69 articles)	AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo	Daniel
Genomics (69 articles)	Steroids, Inflammation, and CAR-T Therapy	Daniel
Genomics (69 articles)
Resistance and Adverse Events (12 articles)	Predicting Tumor Response, Progression, and Time to Recurrence	Daniel
Resistance and Adverse Events (12 articles)
Patient Care and Personalized Care (12 articles)	Harnessing Personalized Medicine for Cancer Management, Prospects of Prevention and Cure: Opinions of Cancer Scientific Leaders @ http://pharmaceuticalintelligence.com	Aviva
Patient Care and Personalized Care (12 articles)
Cancer Models and Research (12 articles)	Humanized Mice May Revolutionize Cancer Drug Discovery	Aviva
Cancer Models and Research (12 articles)

Article Title (Live Link)	All Time Views	Categories of Research
#1 Targeting the Wnt Pathway [7.11]	3,233	Academic Publishing, Biochemical pathways, Biological Networks, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Curation, Disease Biology, Gastroenterology, Gene Regulation, Genetics & Innovations in Treatment, Liver & Digestive Diseases Research, Metabolism

#1

Targeting the Wnt Pathway [7.11]

Article #1: Word Cloud by NT

 

Article Title (Live Link)	All Time Views	Categories of Research
#2 Warburg Effect and Mitochondrial Regulation- 2.1.3	~361	Academic Publishing, Amino acids, Anaerobic Glycolysis, Biochemical pathways, Biological Networks, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Chemical Biology and its relations to Metabolic Disease, Clinical Diagnostics, Curation, Cytoskeleton, Developmental biology, Disease Biology, Enzyme Induction, Enzymes and isoenzymes, Fatty acids, Gene Regulation, Genomic Expression, Hexokinase, Inosine nucleotides, Lipid metabolism, Lipids, Liver & Digestive Diseases Research, Loss of function gene, Metabolism, Metabolomics, Methods, mtDNA, Oxidative phosphorylation, Phosphorylation, Proteins, Proteomics, Pyridine nucleotides, Pyruvate Kinase, Signaling, Signaling & Cell Circuits, Small Molecules in Development of Therapeutic Drugs, Warburg effect

#2

Warburg Effect and Mitochondrial Regulation- 2.1.3

Article #2: Word Cloud by DM

• 

Article Title (Live Link)	All Time Views	Categories of Research
#3 Cancer Mutations Across the Landscape	~173	Biological Networks, Gene Regulation and Evolution, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Computational Biology/Systems and Bioinformatics, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Genome Biology, Genomic Testing: Methodology for Diagnosis, Medical and Population Genetics, Molecular Genetics & Pharmaceutical, Personalized and Precision Medicine & Genomic Research

#3

Cancer Mutations Across the Landscape

Article #3: Word Cloud by DM

• 

Article Title (Live Link)	All Time Views	Categories of Research
#4 Targeting Cancer Neoantigens and Metabolic Change in T-cells	~263	Apoptosis, Autophagy, CANCER BIOLOGY & Innovations in Cancer Therapy, Clinical & Translational, Curation, Immunology, Immunotherapy, Inflammasome

#4

Targeting Cancer Neoantigens and Metabolic Change in T-cells

Article #4: Word Cloud by NT

Article Title (Live Link)	All Time Views	Categories of Research
#5 In Search of Clarity on Prostate Cancer Screening, Post-Surgical Followup, and Prediction of Long Term Remission	~134	Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound, Personalized and Precision Medicine & Genomic Research, Pharmaceutical Industry Competitive Intelligence

#5

In Search of Clarity on Prostate Cancer Screening, Post-Surgical Followup, and Prediction of Long Term Remission

Article #5: Word Cloud by DM

Article Title (Live Link)	All Time Views	Categories of Research
#6 State of the art in oncologic imaging of Prostate	~204	Bio Instrumentation in Experimental Life Sciences Research, Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, Ecosystems & Industrial Concentration in the Medical Device Sector, Health Economics and Outcomes Research, Imaging-based Cancer Patient Management, Medical Devices R&D and Inventions, Medical Devices R&D Investment, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound, Personalized and Precision Medicine & Genomic Research

#6

State of the art in oncologic imaging of Prostate

Article #6: Word Cloud by NT

Article Title (Live Link)	All Time Views	Categories of Research
#7 Neuroblastoma: A review	689	Biomarkers & Medical Diagnostics, BioSimilars, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Prevention: Research & Programs, Cell Biology, Signaling & Cell Circuits, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Genome Biology, Personalized and Precision Medicine & Genomic Research, Population Health Management, Genetics & Pharmaceutical

#7

Neuroblastoma: A Review

Article #7: Word Cloud by NT

Article Title (Live Link)	All Time Views	Categories of Research
#8 Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?	17,152	Biological Networks, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Disease Biology, Genome Biology, Imaging-based Cancer Patient Management, International Global Work in Pharmaceutical, Liver & Digestive Diseases Research, Metabolomics, Molecular Genetics & Pharmaceutical, Nutrition, Pharmaceutical Industry Competitive Intelligence, Pharmaceutical R&D Investment, Population Health Management, Proteomics, Stem Cells for Regenerative Medicine, Technology Transfer: Biotech and Pharmaceutical

#8

Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?

Article #8: Word Cloud by DM

Article Title (Live Link)	All Time Views	Categories of Research
#9 How Mobile Elements in “Junk DNA Promote Cancer – Part 1: Transposon-mediated Tumorigenesis”	928	Biological Networks, Gene Regulation and Evolution, CANCER BIOLOGY & Innovations in Cancer Therapy, Computational Biology/Systems and Bioinformatics, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Genome Biology, Health Economics and Outcomes Research, Molecular Genetics & Pharmaceutical, Personalized and Precision Medicine & Genomic Research, Uncategorized

#9

How Mobile Elements in “Junk DNA Promote Cancer – Part 1: Transposon-mediated Tumorigenesis”

Article #9: Word Cloud by DM

Article Title (Live Link)	All Time Views	Categories of Research
#10 Akt inhibition for cancer treatment, where do we stand today?	4,873	CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits

#10

Akt inhibition for cancer treatment, where do we stand today?

Article #10: Word Cloud by DM

Article Title (Live Link)	All Time Views	Categories of Research
#11 Thymosin alpha1 and melanoma	~573	Bio Instrumentation in Experimental Life Sciences Research, Biomarkers & Medical Diagnostics, BioSimilars, CANCER BIOLOGY & Innovations in Cancer Therapy, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Drug Delivery Platform Technology, Health Economics and Outcomes Research, Human Immune System in Health and in Disease, Population Health Management, Genetics & Pharmaceutical, Regulated Clinical Trials: Design, Methods, Components and IRB related issues

#11

Thymosin alpha1 and melanoma

Article #11: Word Cloud by DM

Article Title (Live Link)	All Time Views	Categories of Research
#12 AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo	3,473	Biological Networks, Gene Regulation and Evolution, BioSimilars, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, Chemical Genetics, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Genome Biology, Health Economics and Outcomes Research, Metabolomics, Molecular Genetics & Pharmaceutical, Nutrigenomics, Personalized and Precision Medicine & Genomic Research

#12

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

Article #12: Word Cloud by DM

Article Title (Live Link)	All Time Views	Categories of Research
#13 Steroids, Inflammation, and CAR-T Therapy]	828	Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, FDA, FDA Regulatory Affairs, Immuno-Oncology & Genomics, Innovation in Immunology Diagnostics, Lymphoma, Personal Health Applications: Tech Innovations serves HealhCare, Personalized and Precision Medicine & Genomic Research

#13

Steroids, Inflammation, and CAR-T Therapy

Article #13: Word Cloud by DM

• 

Article Title (Live Link)	All Time Views	Categories of Research
#14 Predicting Tumor Response, Progression, and Time to Recurrence	504	Bio Instrumentation in Experimental Life Sciences Research, Biological Networks, Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Chemical Genetics, Computational Biology/Systems and Bioinformatics, Disease Biology, Gene Regulation and Evolution, Genome Biology, Genomic Testing: Methodology for Diagnosis, Imaging-based Cancer Patient Management, Signaling & Cell Circuits, Small Molecules in Development of Therapeutic Drugs, Technology Transfer: Biotech and Pharmaceutical

#14

Predicting Tumor Response, Progression, and Time to Recurrence

Article #14: Word Cloud by DM

Article Title (Live Link)	All Time Views	Categories of Research
#15 Harnessing Personalized Medicine for Cancer Management, Prospects of Prevention and Cure: Opinions of Cancer Scientific Leaders @ http://pharmaceuticalintelligence.com	~216	CANCER BIOLOGY & Innovations in Cancer Therapy, Interviews with Scientific Leaders

#15

Harnessing Personalized Medicine for Cancer Management, Prospects of Prevention and Cure: Opinions of Cancer Scientific Leaders @ http://pharmaceuticalintelligence.com

Article #15: Word Cloud by ZD

• 

Article Title (Live Link)	All Time Views	Categories of Research
#16 Humanized Mice May Revolutionize Cancer Drug Discovery	~341	BioTechnology – Venture Creation, BioTechnology – Venture Creation, Venture Capital, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Monoclonal Immunotherapy, Patents, Pharmaceutical Drug Discovery, Pharmacodynamics and Pharmacokinetics

#16

Humanized Mice May Revolutionize Cancer Drug Discovery

Article #16: Word Cloud by ZD

• 

CATEGORIZATION OF THE UNIVERSE OF CANCER OFFERINGS IN THE AGORA OF LPBI

Purpose: To Curate a listing of articles in CANCER for the purpose of generating WordClouds for eventual Natural Language Processing

Initial Request: Aviva requested 12 articles in CANCER to be used to generate a WordCloud for AI machine learning

Problem: Only 12 article only represents less than 1% of all CANCER OFFERINGS by LPBI and would severely limit the ability to generate a meaningful WordCloud. Dr Williams then used a methodology to curate a meaningful list which could be repeated on extended offerings and subjects.

Solution: Dr. Williams generated a listing of all Cancer articles which had been viewed at least 131 times. They could either be authored, curated, written, or reported articles. The initial list was generated by Daniel, Chief Technology Officer. This listing was generated as an Excel worksheet. (A Total of 1555 articles had views of at least 133 total all time views of which 352 were explicitly on Cancer. Each article was read for content).

• Williams then categorized each article according to the STYLE in which it was written as follows
  • Authored; requires original thought, ideas, and multiple references; has a methodology
  • Curated; multiple disparate sources connected by a theme generated by the curator
  • Written: as a writer; only one or two references but having some input into content
  • Reported: an article which only reports on a topic or event; usually a new report or press announcement

Of the 352 CANCER articles, there were 69 AUTHORED, 178 CURATED, 16 WRITTEN, and 89 REPORTED articles

• Williams, after categorizing the STYLE, then categorized the AUTHORED, CURATED, AND WRITTEN articles (263 articles) based on the following subject material categories:
  • Therapeutic (69 articles)
  • Diagnosis (36 articles)
  • Imaging (16 articles)
  • Mechanisms of tumorigenesis (40 articles)
  • Genomics (69 articles)
  • Resistance and Adverse Events (12 articles)
  • Patient Care and Personalized Care (12 articles)
  • Cancer Models and Research (12 articles)

The following tables represent the articles in each sub-category

Therapeutic (69 articles)

Akt inhibition for cancer treatment, where do we stand today?

Crucial role of Nitric Oxide in Cancer

Targeting Mitochondrial-bound Hexokinase for Cancer Therapy

The Development of siRNA-Based Therapies for Cancer

Nanotech Therapy for Breast Cancer

Thymosin alpha1 and melanoma

What can we expect of tumor therapeutic response?

β Integrin emerges as an important player in mitochondrial dysfunction associated Gastric Cancer

Personalized Medicine and Colon Cancer

Pancreatic Cancer: a discovery in Toulouse that would slow its progression

Quantitative Systems Pharmacology – Use in Oncology Clinical Development: Anna Georgieva Kondic, PhD

Predicting Tumor Response, Progression, and Time to Recurrence

Usp9x: Promising therapeutic target for pancreatic cancer

Targeting Epithelial To Mesenchymal Transition (EMT) As A Therapy Strategy For Pancreatic Cancer

VEGF activation and signaling, lysine methylation, and activation of receptor tyrosine kinase

Brain Cancer Vaccine in Development and other considerations

Paclitaxel vs Abraxane (albumin-bound paclitaxel)

Mesothelin: An early detection biomarker for cancer (By Jack Andraka)

Confined Indolamine 2, 3 dioxygenase (IDO) Controls the Hemeostasis of Immune Responses for Good and Bad

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

Targeting the Wnt Pathway [7.11]

Monoclonal Antibody Therapy and Market

Non-small Cell Lung Cancer drugs – where does the Future lie?

CD47: Target Therapy for Cancer

Peroxisome proliferator-activated receptor (PPAR-gamma) Receptors Activation: PPARγ transrepression for Angiogenesis in Cardiovascular Disease and PPARγ transactivation for Treatment of Diabetes

Cardio-oncology and Onco-Cardiology Programs: Treatments for Cancer Patients with a History of Cardiovascular Disease

Mitochondrial fission and fusion: potential therapeutic targets?

Heroes in Medical Research: Barnett Rosenberg and the Discovery of Cisplatin

Imatinib (Gleevec) May Help Treat Aggressive Lymphoma: Chronic Lymphocytic Leukemia (CLL)

Lung Cancer (NSCLC), drug administration and nanotechnology

Soft Tissue Sarcoma: an Overview

Steroids, Inflammation, and CAR-T Therapy

14th ANNUAL BIOTECH IN EUROPE FORUM For Global Partnering & Investment 9/30 – 10/1/2014 • Congress Center Basel – SACHS Associates, London

Moderna Therapeutics Deal with Merck: Are Personalized Vaccines here?

Good and Bad News Reported for Ovarian Cancer Therapy

Topoisomerase 1 inhibitors and cancer therapy

J.P. Morgan 34th Annual Healthcare Conference & Biotech Showcase™ January 11 – 15, 2016 in San Francisco

Bisphosphonates and Bone Metabolism

Cancer Immunotherapy

Signaling of Immune Response in Colon Cancer

Oncolytic Virus Immuno-Therapy: New Approach for a New Class of Immunotherapy Drugs

Angiogenesis Inhibitors [9.5]

Novel Approaches to Cancer Therapy [11.1]

Findings on Bacillus Calmette–Guérin (BCG) for Superficial Bladder Cancer

Are CXCR4 Antagonists Making a Comeback in Cancer Chemotherapy?

The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum Promoting Public & Private Sector Collaboration & Investment in Drug Development, 19th March 2014 • New York Academy of Sciences • USA

Bispecific and Trispecific Engagers: NK-T Cells and Cancer Therapy

Immune-Oncology Molecules In Development & Articles on Topic in @pharmaceuticalintelligence.com

Monoclonal Antibody Therapy: What is in the name or clear description?

Nanoparticle Delivery to Cancer Drug Targets

Autophagy-Modulating Proteins and Small Molecules Candidate Targets for Cancer Therapy: Commentary of Bioinformatics Approaches

Immunotherapy in Cancer: A Series of Twelve Articles in the Frontier of Oncology by Larry H Bernstein, MD, FCAP

2014 MassBio Annual Meeting 4/3 – 4/4 2014, Royal Sonesta Hotel, Cambridge, MA

AACR2016 – Cancer immunotherapy

Report on Cancer Immunotherapy Market & Clinical Pipeline Insight

CD-4 Therapy for Solid Tumors

In focus: Melanoma therapeutics

Allogeneic Stem Cell Transplantation [9.3]

Cyclic Dinucleotides and Histone deacetylase inhibitors

Cancer Innovations from across the Web

“””Thymosin alpha1 and melanoma””,168

NGS Market: Trends and Development for Genotype-Phenotype Associations Research”””

Myelodysplastic syndrome and acute myeloid leukemia following adjuvant chemotherapy

Cancer Cell Therapy: Global Start up Acquisitions in Oncolytic Viruses (OV) Therapeutics – a Pipeline of 70 OVs in Clinical Development and another 95 in Preclinical Programs

Cancer Vaccines: Targeting Cancer Genes for Immunotherapy – A Conference by Keystone Symposia on Molecular and Cellular Biology

IDO for Commitment of a Life Time: The Origins and Mechanisms of IDO, indolamine 2, 3-dioxygenase

The Delicate Connection: IDO (Indolamine 2, 3 dehydrogenase) and Cancer Immunology

Advances in Cancer Immunotherapy

COMBAT study: Combination of BL-8040 and KEYTRUDA® (pembrolizumab) for Pancreatic Cancer: Collaboration Agreement Merck, BioLineRx and MD Anderson Cancer Center

DIAGNOSIS (36 articles)

Nanotechnology: Detecting and Treating metastatic cancer in the lymph node

Acute Lymphoblastic Leukemia (ALL) and Nanotechnology

Role of Progesterone in Breast Cancer Progression

Today’s fundamental challenge in Prostate cancer screening

Sensors and Signaling in Oxidative Stress

City of Hope, Duarte, California – Combining Science with Soul to Create Miracles at a Comprehensive Cancer Center designated by the National Cancer Institute – An Interview with the Provost and Chief Scientific Officer of City of Hope, Steven T. Rosen, M.D.

In Focus: Identity of Cancer Stem Cells

Thermodynamic Modeling for Cancer Cells

Glypican-1 identifies cancer exosomes

Ultrasound-based Screening for Ovarian Cancer

Ovarian Cancer and fluorescence-guided surgery: A report

Diagnosing Lung Cancer in Exhaled Breath using Gold Nanoparticles

Pancreatic Cancer at the Crossroads of Metabolism

Virtual Biopsy – is it possible?

Prostate Cancer and Nanotecnology

Metabolomics based biomarker discoveries

Personalized Medicine: Cancer Cell Biology and Minimally Invasive Surgery (MIS)

Pancreatic Cancer Targeted Treatment?

Breast Cancer: Genomic profiling to predict Survival: Combination of Histopathology and Gene Expression Analysis

Targeting Cancer Neoantigens and Metabolic Change in T-cells

Cancer Immunotherapy Conference & Biomarkers for Cancer Immunotherapy Symposium, March 6-11, 2016 | Moscone North Convention Center | San Francisco, CA

New insights in cancer, cancer immunogenesis and circulating cancer cells

Circulating Biomarkers World Congress, March 23-24, 2015, Boston: Exosomes, Microvesicles, Circulating DNA, Circulating RNA, Circulating Tumor Cells, Sample Preparation

Prostate Cancer: Diagnosis and Novel Treatment – Articles of Note @PharmaceuticalIntelligence.com

Cancer Biomarkers

What about PDL-1 in oncotherapy diagnostics for NSCLC?

Novel biomarkers for targeting cancer immunotherapy

Hematological Cancer Classification

Cancer Biomarkers [11.3.2.3]

In Search of Clarity on Prostate Cancer Screening, Post-Surgical Followup, and Prediction of Long Term Remission

Biomarkers identified for recurrence in HBV-related HCC patients post surgery

Recent comprehensive review on the role of ultrasound in breast cancer management

Automated Breast Ultrasound System (‘ABUS’) for full breast scanning: The beginning of structuring a solution for an acute need!

“””The Molecular pathology of Breast Cancer Progression””,296

Medical MEMS BioMEMS and Sensor Applications”””

Battle of Steve Jobs and Ralph Steinman with Pancreatic cancer: How we lost

Metabolic drivers in aggressive brain tumors

IMAGING (16 articles)

Nanotechnology and MRI imaging

The unfortunate ending of the Tower of Babel construction project and its effect on modern imaging-based cancer patients’ management

Improving Mammography-based imaging for better treatment planning

State of the art in oncologic imaging of Colorectal cancers.

State of the art in oncologic imaging of Prostate.

Imaging Technology in Cancer Surgery

State of the art in oncologic imaging of lungs.

Causes and imaging features of false positives and false negatives on 18F-PET/CT in oncologic imaging

Clinical Trials on Schwannoma & Benign Intracranial Tumors Radiosurgery Treatment

Whole-body imaging as cancer screening tool; answering an unmet clinical need?

Improving Mammography-based imaging for better treatment planning

Imaging: seeing or imagining? (Part 1)

Knowing the tumor’s size and location, could we target treatment to THE ROI by applying imaging-guided intervention?

Imaging: seeing or imagining? (Part 2)

Tumor Imaging and Targeting: Predicting Tumor Response to Treatment: Where we stand?

State of the art in oncologic imaging of breast.

Mechanisms of tumorigenesis (40 articles)

Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?

In focus: Circulating Tumor Cells

Summary of Transcription, Translation ond Transcription Factors

Mitochondria: More than just the “powerhouse of the cell”

How Mobile Elements in “Junk DNA Promote Cancer – Part 1: Transposon-mediated Tumorigenesis”

Demythologizing sharks, cancer, and shark fins

A Synthesis of the Beauty and Complexity of How We View Cancer

Neuroblastoma: A review

Refined Warburg Hypothesis -2.1.2

Introduction – The Evolution of Cancer Therapy and Cancer Research: How We Got Here?

Epistemology of the Origin of Cancer: a New Paradigm

Role of Primary Cilia in Ovarian Cancer

Prologue to Cancer – e-book Volume One – Where are we in this journey?

“””The Molecular pathology of Breast Cancer Progression””, 325

Ultrasound-based Screening for Ovarian Cancer”””

The “Cancer establishments examined by James Watson 4/1953”

Lipids link to breast cancer

“””Thymosin alpha1 and melanoma””, 169

Amplifying Information Using S-Clustering and Relationship to Kullback-Liebler Distance: An Application to Myocardial Infarction”””

Wnt/β-catenin Signaling [7.10]

Cancer Signaling Pathways and Tumor Progression: Images of Biological Processes in the Voice of a Pathologist Cancer Expert

Mitochondrial Damage and Repair under Oxidative Stress

Nitric Oxide has a Ubiquitous Role in the Regulation of Glycolysis – with a Concomitant Influence on Mitochondrial Function

Autophagy

Ubiquitin-Proteosome pathway, Autophagy, the Mitochondrion, Proteolysis and Cell Apoptosis: Part III

Pancreatic Cancer and Crossing Roads of Metabolism

Ubiquinin-Proteosome pathway, autophagy, the mitochondrion, proteolysis and cell apoptosis

Warburg Effect Revisited – 2

Prostate Cancer Cells: Histone Deacetylase Inhibitors Induce Epithelial-to-Mesenchymal Transition

Naked Mole Rats Cancer-Free

In focus: Triple Negative Breast Cancer

Heat Shock Proteins (HSP) and Molecular Chaperones

Nonhematologic Cancer Stem Cells [11.2.3]

Mitochondria and Cancer: An overview of mechanisms

Growth Factors, Suppressors and Receptors in Tumorigenesis [7.1]

Upregulate Tumor Suppressor Pathways [7.5]

Nrf2 Role in Blocking DNA Damage

Prostate Cancer: Androgen-driven “Pathomechanism in Early-onset Forms of the Disease”

Cancer Metastasis

Halstedian model of cancer progression

Otto Warburg, A Giant of Modern Cellular Biology

Tang Prize for 2014: Immunity and Cancer

Genomics (69 articles)

Pancreatic Cancer: Genetics, Genomics and Immunotherapy

Summary of Signaling and Signaling Pathways

In focus: Melanoma Genetics

Multiple Lung Cancer Genomic Projects Suggest New Targets, Research Directions for Non-Small Cell Lung Cancer

Multiple Lung Cancer Genomic Projects Suggest New Targets, Research Directions for Non-Small Cell Lung Cancer

Stanniocalcin: A Cancer Biomarker.

The Underappreciated EpiGenome

Li -Fraumeni Syndrome and Pancreatic Cancer

“To Die or Not To Die” – Time and Order of Combination drugs for Triple Negative Breast Cancer cells: A Systems Level Analysis

Genome-Wide Detection of Single-Nucleotide and Copy-Number Variation of a Single Human Cell

Metabolomics and prostate cancer

“The Molecular pathology of Breast Cancer Progression”, 172 Bioinformatic Tools for Cancer Mutational Analysis: COSMIC and Beyond”

Personalized Medicine in NSCLC

Notes On Tumor Heterogeneity: Targets and Mechanisms, from the 2015 AACR Meeting in Philadelphia PA

AstraZeneca’s WEE1 protein inhibitor AZD1775 Shows Success Against Tumors with a SETD2 mutation

A Primer on DNA and DNA Replication

Integrins, Cadherins, Signaling and the Cytoskeleton

The Molecular pathology of Breast Cancer Progression

Signaling transduction tutorial

Hematologic Malignancies [2.4.3]

Sunitinib brings Adult Acute Lymphoblastic Leukemia (ALL) to Remission – RNA Sequencing – FLT3 Receptor Blockade

Hypoxia Inducible Factor 1 (HIF-1)[7.9]

Observations on Human Papilloma Virus and Cancer

The role and importance of transcription factors

Differentiation Therapy – Epigenetics Tackles Solid Tumors

CRISPR-Cas9 Foundational Technology originated at UC, Berkeley & UCSF, Broad Institute is developing Biotech Applications — Intellectual Property emerging as Legal Potential Dispute

Bioinformatic Tools for Cancer Mutational Analysis: COSMIC and Beyond

Issues in Personalized Medicine: Discussions of Intratumor Heterogeneity from the Oncology Pharma forum on LinkedIn

The Human Proteome Map Completed

CRISPR/Cas9 Finds Its Way As an Important Tool For Drug Discovery & Development

Mitochondrial Isocitrate Dehydrogenase and Variants

Pathway Specific Targeting in Anticancer Therapies [7.7]

Protein-binding, Protein-Protein interactions & Therapeutic Implications [7.3]

Gene Editing with CRISPR gets Crisper

Delineating a Role for CRISPR-Cas9 in Pharmaceutical Targeting

RNA and the Transcription the Genetic Code

Role of Calcium, the Actin Skeleton, and Lipid Structures in Signaling and Cell Motility

Finding the Genetic Links in Common Disease: Caveats of Whole Genome Sequencing Studies

LEADERS in Genome Sequencing of Genetic Mutations for Therapeutic Drug Selection in Cancer Personalized Treatment: Part 2

Introduction to Metabolomics

CRACKING THE CODE OF HUMAN LIFE: Recent Advances in Genomic Analysis and Disease – Part IIC

Sirtuins [7.8]

Highlights from 8th Annual Personalized Medicine Conference, November 28-29, 2012, Harvard Medical School, Boston, MA

2019 Trends in Precision Medicine: A Perspective from Foundation Medicine

Loss of Gene Islands May Promote a Cancer Genome’s Evolution: A new Hypothesis on Oncogenesis

Warburg Effect and Mitochondrial Regulation- 2.1.3

Cancer Genomics – Leading the Way by Cancer Genomics Program at UC Santa Cruz

The Magic of the Pandora’s Box : Epigenetics and Stemness with Long non-coding RNAs (lincRNA)

HBV and HCV-associated Liver Cancer: Important Insights from the Genome

PostTranslational Modification of Proteins

Cancer Genomic Precision Therapy: Digitized Tumor’s Genome (WGSA) Compared with Genome-native Germ Line: Flash-frozen specimen and Formalin-fixed paraffin-embedded Specimen Needed

eProceeding 2019 Koch Institute Symposium – 18th Annual Cancer Research Symposium – Machine Learning and Cancer, June 14, 2019, 8:00 AM-5:00 PMET MIT Kresge Auditorium, 48 Massachusetts Ave, Cambridge, MA

Genomics and Epigenetics: Genetic Errors and Methodologies – Cancer and Other Diseases

Genomics and Metabolomics Advances in Cancer

Deciphering the Epigenome

Tumor Ammonia Recycling: How Cancer Cells Use Glutamate Dehydrogenase to Recycle Tumor Microenvironment Waste Products for Biosynthesis

Cancer Mutations Across the Landscape

BRCA1 a tumour suppressor in breast and ovarian cancer – functions in transcription, ubiquitination and DNA repair

2016 World Medical Innovation Forum: CANCER, April 25-27, 2016, Partners HealthCare, Boston, at the Westin Hotel, Boston

Winning Over Cancer Progression: New Oncology Drugs to Suppress Passengers Mutations vs. Driver Mutations

Gene Amplification and Activation of the Hedgehog Pathway

Bioinformatics Tool Review: Genome Variant Analysis Tools

Gastric Cancer: Whole-genome reconstruction and mutational signatures

7th Annual Novel Strategies for Kinase Inhibitors Exploring New Therapeutic Areas September 24-25, 2013 | Boston, MA

Targeting Untargetable Proto-Oncogenes

Salivary Gland Cancer – Adenoid Cystic Carcinoma: Mutation Patterns: Exome- and Genome-Sequencing @ Memorial Sloan-Kettering Cancer Center

Heroes in Medical Research: Dr. Robert Ting, Ph.D. and Retrovirus in AIDS and Cancer

DNA: One man’s trash is another man’s treasure, but there is no JUNK after all

PIK3CA mutation in Colorectal Cancer may serve as a Predictive Molecular Biomarker for adjuvant Aspirin therapy

Resistance and Adverse Events (12 articles)

Tumor Associated Macrophages: The Double-Edged Sword Resolved?

Predicting Tumor Response, Progression, and Time to Recurrence

Development of Chemoresistance to Targeted Therapies: Alterations of Cell Signaling & the Kinome

Can IntraTumoral Heterogeneity Be Thought of as a Mechanism of Resistance?

Rapid regression of HER2 breast cancer

Liver Toxicity halts Clinical Trial of IAP Antagonist for Advanced Solid Tumors

Myc and Cancer Resistance

Mechanisms of Drug Resistance

New Generation of Platinated Compounds to Circumvent Resistance

Breast Cancer, drug resistance, and biopharmaceutical targets

Issues Need to be Resolved With ImmunoModulatory Therapies: NK cells, mAbs, and adoptive T cells

Curation of Recently Halted Oncology Trials Due to Serious Adverse Events – 2015

Patient and Personalized Care (12 articles)

The Experience of a Patient with Thyroid Cancer

Management of Follicular Lymphoma

Acoustic Neuroma, Neurinoma or Vestibular Schwannoma: Treatment Options

Can Mobile Health Apps Improve Oral-Chemotherapy Adherence? The Benefit of Gamification.

The Relation between Coagulation and Cancer affects Supportive Treatments

NIH Considers Guidelines for CAR-T therapy: Report from Recombinant DNA Advisory Committee

Ethical Concerns in Personalized Medicine: BRCA1/2 Testing in Minors and Communication of Breast Cancer Risk

Cancer and Nutrition

Harnessing Personalized Medicine for Cancer Management, Prospects of Prevention and Cure: Opinions of Cancer Scientific Leaders @ http://pharmaceuticalintelligence.com

Environment and Cancer [11.3.4]

Hormonal Therapy, Complementary and Alternative Therapies – 9.4

Relation of Diet and Cancer

Research and Cancer Models (12 articles)

The SCID Pig: How Pigs are becoming a Great Alternate Model for Cancer Research

The SCID Pig II: Researchers Develop Another SCID Pig, And Another Great Model For Cancer Research

The Discovery and Properties of Avemar – Fermented Wheat Germ Extract: Carcinogenesis Suppressor

Zebrafish—Susceptible to Cancer

Humanized Mice May Revolutionize Cancer Drug Discovery

Heroes in Medical Research: Developing Models for Cancer Research

Recent Breakthroughs in Cancer Research at the Technion-Israel Institute of Technology- 2015

Guidelines for the welfare and use of animals in cancer research

Colon cancer and organoids

Organoid Development

New Ecosystem of Cancer Research: Cross Institutional Team Science

Koch Institute for Integrative Cancer Research @MIT – Summer Symposium 2014: RNA Biology, Cancer and Therapeutic Implications, June 13, 2014 8:30AM – 4:30PM, Kresge Auditorium @MIT

In the following now we will pick articles based on an even distribution between the subcategories