Roles at http://pharmaceuticalintelligence.com
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Inactive – Chief Scientific Officer
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Past Member of the Board
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Inactive Research Categories Owner & Contributing Curator:
- Biomarkers & medical diagnosis in Pathology (Co-Owner)
- Clinical Trials and IRB related Issues
- Acute and Chronic Disease Classifications
- Biomarker Discovery and Validation
- Cardiovascular Research
- Clinical Laboratory-Related Issues
- Healthcare and Hospital Costs
- Health Information Technology and Workflow Redesign
- Metabolomics
- Metabolic Derangements
- Nutraceuticals
- Nutrigenomics
- Nutrition
- Nutrition and Phytochemistry
- Proteomics
- Statistical Methods for Research Evaluation
- Systemic Inflammatory Response Related Disorders
UPDATED on 10/12/2020
Interview with Dr. Larry H. Bernstein, an icon in the medical field, by Dr. Stephen Williams
Welcome to E-Voices, our podcast series exploring cutting-edge science and medical topics, sponsored by the Leaders in Pharmaceutical Business Intelligence. I’m Dr. Stephen Williams, your host for this podcast.
Today’s guest is Dr. Larry H. Bernstein, M.D., FACP, who has had a stellar career in medicine. He is a retired pathologist, pathophysiologist, histologist, bacteriologist, chemical geneticist, biochemist, enzymologist, molecular biologist and mathematical statistician.
Since Dr. Bernstein is not available to record this audio podcast with us, he provided us with answers to several questions plus gave us a biographic review of his life.
Most recently, Dr. Bernstein served as Chief of the Division of Clinical Pathology at New York Methodist Hospital-Weill Cornell Affiliate in Brooklyn, New York, followed by an interim consultancy at Norwalk Hospital in Connecticut. Previously, he was Chief of Clinical Chemistry and Chief of the Blood Bank at Bridgeport Hospital also in Connecticut and Acting Chairperson of Yale University’s Department of Pathology at Bridgeport Hospital.
For many years, he was the Chief Scientific Officer and Member of the Board of Leaders in Pharmaceutical Business Intelligence (LPBI) Group, a pharmaceutical media venture with several cloud-based products, such as an open-access online scientific journal called PharmaceuticalIntelligence.com, a BioMed e-Series of 16 volumes in Medicine, real-time press coverage of biotech and medical conferences, and a podcast library of Interviews with key opinion leaders, all involving a team of experts, authors and writers in science and medicine.
Dr. Bernstein had contributed 1,400 curated articles to LPBI’s Journal and served as an Editor and Content Consultant to each of the 16 volumes in LPBI’s BioMed e-Series. Examples of the top articles in the Journal by e-Reader views shows the cardinal positioning of Dr. Bernstein’s publications. The small sample reflects a glimpse of the topics that he had covered in his writing.
In addition, in 2020, the Journal ontology has 700 categories of research, at least 50 percent were created by Dr. Bernstein to allow precise classification of the wide range of topics his body of research had covered, namely Cancer, Genomics, Pathology, Coagulation, Cardiovascular, Nutrition, Cell Biology and biochemistry processes.
Dr. Bernstein served on the Board of Directors of NAACLS and the American Library Association Commission on Accreditation and he is listed in the America’s Top Physicians. He has three patents in the areas of malate dehydrogenase, an enzyme which plays an important role in the body’s metabolic pathway. He also co-chaired the First International Transthyrein Congress in Strasbourg, at the invitation of Yves Ingenbleek, M.D., PH.D., Professor of Pharmacology at the University of Louis Pasteur in Strasbourg. Additionally, he chaired the 14th Ross Roundtable on Nutrition and was an invited participant at the 17th Ross Roundtable and chaired the Beckman Roundtable on Prealbumin in Los Angeles, California. He was responsible for the American Association for Clinical Chemistry’s first document of Standards of Clinical Laboratory Practice with Lawrence Kaplan and he was the recipient of the Labbe/Garry award of the Nutrition Division of AACC.
We asked Dr. Bernstein if he…Could you tell us about the research project that had the most significance in his career?
He responded by saying…The mechanism of action of mitochondrial malate dehydrogenase (MDH) isonzyme and the inhibition by the combination of the reduced coenzyme (NAD+), MDH and the substrate oxaloacetate (OAA) as the forward reaction proceeds, which is similar to the reaction of lactate dehydrogenase (LDH), NAD+ and pyruvate, except for the lack of inhibition of the muscle type LDH. The role of this reaction in cancer cells, with implication for the Warburg effect…suppressed oxidation of cancer cells.
Dr. Bernstein worked with two noted researchers – Prof. Gil David, who was a postdoctoral student under Prof. Ronald Coifman, who was past Chairman of Mathematics at Yale University – to develop a software system which is today’s equivalent of electronic health records. He commented on this breakthrough and its value to patients and physicians by saying…
Prof. Gil David and Dr. Bernstein had developed, in consultation with Prof. Ronald Coifman, in the Yale University Applied Mathematics Program, a software system that is the equivalent of an Electronic Health Records Dashboard, that provides empirical medical reference and suggests quantitative diagnostics options. Their dashboard was a visual display of essential metrics.
The primary purpose of their research was to gather medical information, generate metrics, analyze the data in real-time and provide a health diagnosis for an individual’s medical condition, meeting the highest standard of accuracy. The medical diagnosis then provides a risk assessment to the patient’s medical condition, while locating and presenting similar cases of other patients with the same anomalous profile and their corresponding treatment and follow-up. Given medical information of a patient, the system builds its unique characterization and provides a list of other patients that share this unique profile, therefore utilizing the vast aggregated knowledge, such as diagnosis, analysis, treatment) of the medical community.
The main mathematical breakthroughs in creating this software system are provided by accurate patient profiling and inference methodologies in which anomalous sub-profiles are extracted and compared to potentially relevant cases. Their methodologies organize numerical medical data profiles into demographics and characteristics relevant for inference and case tracking. As the model grows and its knowledge database is extended, the diagnostic capabilities become more accurate and precise.
They anticipated that the effect of implementing this diagnostic amplifier would result in higher physician productivity at a time of great human resource limitations, safer prescribing practices, rapid identification of unusual patients, better assignment of patients to observation, inpatient beds, intensive care, or referral to clinic, shortened length of patients’ ICU and bed days.
Dr. Bernstein’s research in nutrition was extensive. He shared his early work in the Burn and Wound Care Unit at Bridgeport Hospital along with Dr. Walter Pleban, a leading physician in burn and wound care by saying…
Dr. Bernstein began the studies after reviewing the work in Boston on the evaluation of patients for malnutrition prior to surgery by an observation of arm muscle circumference weight loss and serum albumin. This was preceded by the work in Philadelphia, and later in Houston by Stanley Dudrick on malnutrition in children and in surgical patients. Dr. Dudrick became the Chairman of Surgery at Bridgeport Hospital before his retirement.
The problem that Dr. Bernstein was concerned with was the inadequacy of serum albumin, the half-life being too long. He studied the protein transthyretin (then referred to as prealbumin) after following the work by Yves Ingenbleek at the University of Louis Pasteur in France.
We asked Dr. Bernstein about his opinion on the future of cancer therapeutics.
He responded by saying…The progress has been good and has varied depending on type. There has been enormous progress in genomics, but much work on metabolic pathways is needed.
We asked Dr. Bernstein about the promise of precision medicine and what needed to be accomplished in the coming decade.
He responded by saying…that he thinks that more than a decade will be needed.
We asked Dr. Bernstein about his interpretation of COVID-19, a complex disease.
He responded by saying…It is not more complex than other viral diseases. It has come at a time that good science is not valued.
Enjoy the podcast!
Please click here to listen to an expanded life and times of Larry H. Bernstein, M.D.
My Life in Medicine: Larry H. Bernstein, M.D.
www.linkedin.com/pub/larry-h-bernstein/a/599/50
I retired from a five year position as Chief of the Division of Clinical Pathology (Laboratory Medicine) at New York Methodist Hospital-Weill Cornell Affiliate, Park Slope, Brooklyn in 2008 folowed by an interim consultancy at Norwalk Hospital in 2010. I then became engaged with a medical informatics project called “Second Opinion” with Gil David and Ronald Coifman, Emeritus Professor and Chairman of the Department of Mathematics in the Program in Applied Mathematics at Yale. I went to Prof. Coifman with a large database of 30,000 hemograms that are the most commonly ordered test in medicine because of the elucidation of red cell, white cell and platelet populations in the blood. The problem boiled down to a level of noise that exists in such data, and developing a primary evidence-based classification that technology did not support until the first decade of the 21st century.
Realtime Clinical Expert Support and Validation System
Gil David and Larry Bernstein have developed, in consultation with Prof. Ronald Coifman, in the Yale University Applied Mathematics Program, a software system that is the equivalent of an intelligent Electronic Health Records Dashboard that provides empirical medical reference and suggests quantitative diagnostics options.
Our dashboard is a visual display of essential metrics. The primary purpose is to gather medical information, generate metrics, analyze them in realtime and provide a differential diagnosis, meeting the highest standard of accuracy. The diagnosis provides a risk assessment to the patient’s medical condition, while locating and presenting similar cases of other patients with the same anomalous profile and their corresponding treatment and followup. Given medical information of a patient, the system builds its unique characterization and provides a list of other patients that share this unique profile, therefore utilizing the vast aggregated knowledge (diagnosis, analysis, treatment, etc.) of the medical community.
The main mathematical breakthroughs are provided by accurate patient profiling and inference methodologies in which anomalous subprofiles are extracted and compared to potentially relevant cases. Our methodologies organize numerical medical data profiles into demographics and characteristics relevant for inference and case tracking. As the model grows and its knowledge database is extended, the diagnostic and the prognostic become more accurate and precise.
We anticipate that the effect of implementing this diagnostic amplifier would result in higher physician productivity at a time of great human resource limitations, safer prescribing practices, rapid identification of unusual patients, better assignment of patients to observation, inpatient beds, intensive care, or referral to clinic, shortened length of patients ICU and bed days.
[Second Opinion 2009-2011 Proprietary]
As an example, inputs from test data such as Hematology results are processed for anomaly characterization and compared with similar anomalies in a data base of 30,000 patients, provide diagnostic statistics, warning flags , and risk assessment . These are based on past prior experience , including ,diagnostics and treatment outcomes (collective experience). The system was trained on this database of patients, built the learning knowledge base and used to analysis and diagnosis 5,000 new patients. Our system identified successfully the main risks with very high accuracy (more than 96%) and very low false rate (less than 0.5%).
The main benefit is a real time assessment as well as diagnostic options based on
comparable cases, flags for risk and potential problems as illustrated in the following case acquired on 04/21/10. The patient was diagnosed by our system with severe SIRS at a grade of .61 .
The patient was treated for SIRS and the blood tests were repeated during the following week. Following treatment, the SIRS risk as a major concern was eliminated and the system provides a positive feedback for the treatment of the physician.
To experiment with our demo system using our existing database or your own data it resides online at:
http://netlab2.math.yale.edu:30049/cgi-bin/second opinion.py
[Second Opinion 2009-2011 Proprietary]
I have been reviewing manuscripts somewhat frequently for Nutrition, Clin Chem Lab Med, Clin Biochem, and J Ped Hem Oncol., and serve on the Editorial Advisory Board of Nutrition.
I was the Chief, Clinical Pathology at NY Methodist Hospital, a 600+ bed hospital in Park Slope, Brooklyn, 2 hours from Bridgeport, CT, where I worked for 5 years, and was previously Chief of Clinical Chemistry and Chief of Blood Bank at Bridgeport Hospital for 20 years, and Acting Chairman of Yale University Department of Pathology at Bridgeport Hospital for one year prior to my experience at NY Methodist Hospital Weill-Cornell.
My work with nutrition is extensive as a consulting pathologist on the Nutritional Support Team and I worked closely with the Burn Unit at Bridgeport Hospital, led by Dr. Walter Pleban, the first physician expert in burn and wound care to use TPN in Connecticut. I rejected the dependence on serum albumin and implemented the first use of prealbumin (transthyretin)(half-life of 2 days) to follow the return to anabolic status of severely stressed patients, starting with Immunodiffusion plates from Behring Diagnostics, then converting to running batch turbidimetric assays on the Roche centrifugal analyzer, and finally running on a Beckman. My lab was the only one to get down to reliable measurements of 20 mg/L. I co-chaired the First International Transthyretin Congress in Strasbourg, chaired the 14th and was an invited participant in the 17th Ross Roundtable on Nutrition, Organized and Chaired the Beckman Roundtable on Prealbumin in Los Angeles, was responsible for the AACC first document of Standards of Clinical Laboratory Practice with Lawrence Kaplan, and was recipient of the Labbe/Garry award of the Nutrition Division of AACC). I did some of the earliest work on point of care diagnostics in neonatal care. My work with Creatine kinase isoenzyme MB and the isonze 1 of LD goes back to my residency and my long term contact with Burton Sobel. The improved use of troponins and NT-proBNP and have been ongoing projects for the last 10 years, some of which was supported by Roche Diagnostics on the recommendation of Pauline Lau and Bernard Statland. The projects in normalizing the NT-proBNP for age and estimated glomerular filtration rate (eGFR), was successful, but widespread implementation is even more gradual than was TTR.
I have served on the Board of Directors of NAACLS and the American Library Association Commission on Accreditation, am listed in America’s Top Physicians, Marquis Who’s Who in Science and Engineering and Marquis’ Who’s Who in Medicine, Who’s Who in Pathology, Continental Who’s Who, Strathmore’s Who’s Who, and have 3 patents.
Keywords:
Special Interests:
| Biomarkers Clinical outcomes research |
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| Evidence based research- medical informatics- predictive analytics- information technology-Anomaly Classification- Applied statistics -Multivariate, Neural Networks and Latent Class applications- Medical Statistics and Biostatistics, Quality control and Reliability- Heart Failure, Congestive — blood- Heart Failure, Congestive — diagnosis- Heart Failure, Congestive — physiopathology- Metabolic Syndrome X — blood- Metabolic Syndrome X — metabolism
– Metabolic Syndrome X — physiopathology – Myocardial Infarction — blood – Myocardial Infarction — diagnosis – Myocardial Infarction — physiopathology – Prealbumin — analysis – Prealbumin — biosynthesis – Protein–Energy Malnutrition — blood – Protein–Energy Malnutrition — metabolism – Sepsis Syndrome — blood – Sepsis Syndrome – diagnosis Laboratory Economics Technology Impact |
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GENERAL INFORMATION
| Office address: | 232 Fitch’s Pass, Trumbull, CT |
| Office telephone: | (203) 261-8671 |
| Office fax: | (203) 261-8671 |
| Home address: | 232 Fitch’s PassTrumbull, CT 06611 |
| Home telephone: | 203-261-8671 |
| Cell phone: | 203-257-0486 |
| Beeper: | na |
| Email: | plbern@yahoo.com; larryberns@earthlink.net |
| Country of Citizenship: | U.S.A. |
Optional Information:
| Birth date: | December 28, 1941 | ||||||
| Birth place: | Highland Park, MI | ||||||
| Marital status: | Married | ||||||
| Spouse’s name: | Audrey | ||||||
| Children’s name and ages: | Rachel Naomi | ||||||
| Race/Ethnicity: | W/j | ||||||
| Scientific titles and degrees Wayne State University, Detroit, MI- BS in Chemistry – Bachelor of ScienceReceiving or nomination date: 1963-07-22 | |||||||
| -MS in Anatomy – Master of Science Receiving or nomination date: 1966-06-03 – Title of dissertation:”Ontogeny of the Crystallins of the Lens of the Eye. (Thesis)Bernstein LH, Kerrigan M, Maisel H:Lactic dehydrogenase isoenzymes in lens and cornea. Exptl Eye Res 1966; 5:309Mentor: HarryMaisel | |||||||
| – MD – Doctor of Medicine Receiving or nomination date: 1968-05-10 – | |||||||
| Grants and Research Projects – Malate dehydrogenase and cancer | |||||||
| Grant type: individual (local) 1975-02-17 : 1976-10-22 | |||||||
| – Patentspatent: Malate dehydrogenase methodcontinuation patent : Malate dehydrogenase cancer methodpatent: The lactate dehydrogenase method | |||||||
Publications –
Recent
– . Generating Evidence Based Interpretation of Hematology Screens via Anomaly characterization.
Gil David, Larry H Bernstein, Ronald Coifman
Open Clinical Chemistry Journal 2011; 4(1):10-16
ICID: 939928
Article type: Original article
Larry H. Bernstein, Gil David, James Rucinski and Ronald R. Coifman (2012). Converting Hematology Based Data into an Inferential Interpretation, Hematology – Science and Practice, Charles H. Lawrie (Ed.), ISBN: 978-953-51-0174-1, InTech, Available from:http://www.intechopen.com/articles/show/title/converting-hematology-based-data-to-useful-information
<a href=”http://www.intechopen.com/articles/show/title/converting-hematology-based-data-to-useful-information” title=”Converting Hematology Based Data into an Inferential Interpretation”>Converting Hematology Based Data into an Inferential Interpretation</a>
– C-Reactive Protein for the Enhanced Evaluation of the Systemic Inflammatory Response Syndrome (SIRS)
Gitta Pancer, Ester Engelman, Farhana Hoque, Mohammed Alam, James Rucinski, Larry H Bernstein
Open Clinical Chemistry Journal 2010; 3(3):90-98
ICID: 939929
Article type: Original article
– Calorimetry and metabolic knowledge.
Larry H Bernstein
Nutrition 2010; 26(10):0-951
ICID: 939933
Article type: Editorial
– Reducing pressure ulcer risks in activity-restricted patients: a national imperative.
Larry H Bernstein
Nutrition 2010; 26(9):0-861
ICID: 939935
Article type: Editorial
– Effect of renal function loss on NT-proBNP level variations.
Larry H Bernstein, Michael Y Zions, Salman A Haq, Stuart Zarich, James Rucinski, Bette Seamonds, Stanley Berger, Daniel Y Lesley, William Fleischman, John F Heitner
Clin Biochem 2009; 42(10-11):1091-1098
ICID: 937529
Article type: Original article
– The Automated Nutrition Score is a data-driven extension of continuous quality improvement.
Larry H Bernstein
Nutrition 2009; 25(3):316-317
ICID: 939934
Article type: Editorial
– Enhancing the diagnostic performance of troponins in the acute care setting.
Salman A Haq, Morteza Tavakol, Steven Silber, Larry Bernstein, Jerard Kneifati-Hayek, Madeleine Schleffer, Lesan T Banko, John F Heitner, Terrence J Sacchi, Joseph A Puma
J Emerg Med 2008; 0 0
ICID: 937619
Article type: Original article
– Transthyretin as a marker to predict outcome in critically ill patients.
Arun Devakonda, Liziamma George, Suhail Raoof, Adebayo Esan, Anthony Saleh, Larry H Bernstein
Clin Biochem 2008; 41(14-15):1126-1130
ICID: 939927
Article type: Original article
– The effect of mechanical ventilation on NT-ProBNP Level: A pilot study
A Bishay, A Esan, A Amchentsev, L Irugulapati, R Patel, S Adoni, LH Bernstein,
L George, S Raoof
Chest 2007; 132(4):S456-456
ICID: 939944
Article type: Other
– A model for automated screening of thalassemia in hematology.
Jerard Kneifati-Hayek, William Fleischman, Larry H Bernstein, Anthony Riccioli, Rita Bellevue
Lab Hematol 2007; 13(4):119-123
ICID: 843950
Article type: Original article
– The systemic inflammatory response syndrome C-reactive protein and transthyretin conundrum.
Larry H Bernstein
Clin Chem Lab Med 2007; 45(11):0
ICID: 939932
Article type: Editorial
– Critical Care: Outcomes. Transthyretin as a marker to assess malnutrition in critically ill patients
Arun Devakonda, A Esan, Liziamma George, Suhail Raoof, Larry H Bernstein
Chest 2006; 130(4):S216-216
ICID: 939945
Article type: Original Article
– Anemia as an independent predictor of elevated Pro-BNP levels in patients without evidence of heart failure and normal renal function.
Salman Haq, Mohammed Alam, LarryH Bernstein, L Banko, B Saul, L Lee, Terrence Sacchi, John Heitner
Circulation 2006; 114(18):II771-772
ICID: 939946
Article type: Other
– Serum cortisol level and coronary artery bypass surgery patients. Abstract of poster presentation at meeting of ACCP, Salt Lake City, Utah, October 25, 2006. 230; Abstract no.188S. http://meeting.chestjournal.org/cgi/reprint/130/4/188S- Accessed April 9, 2007. N Mansuroglu, M Ali, Charles Oribabor, V Matatov, Larry H Bernstein, W Elzomoor, W Tinker, M Nazares, D Koloyian, L Lee, Anthony Tortolani
Chest 2006; 130(4):S188-188
ICID: 939966
Article type: Other
– Comparison of test characteristics of cardiac troponin T in patients with normal renal function and chronic renal failure evaluated in the emergency department.
Steve Silber, Lawrence Melniker, Elizabeth Haines, Larry H Bernstein
Academic Emergency Medicine 2006; 13(5):S1186-187
ICID: 939943
Article type: Other
– Cardiac Surgery Variables Affecting Outcomes: Perioperative use of amiodarone in cardiac surgery patients to achieve normal sinus rhythm upon discharge. Abstract of presentation at meeting of ACCP,Montreal, Canada, 2005.
N Mansuroglu, Charles Oribabor, A Tinker, A Mariano, R Slepian, F Gebreab, Larry H Bernstein, L Lee, Anthony Tortolani
Chest 2005; 128(4):S180-180
ICID: 939967
Article type: Other
– The ACC/ESC Recommendation for 99th Percentile of the Reference Normal
Troponin I Overestimates the Risk of an Acute Myocardial Infarction: a novel enhancement in the diagnostic performance of troponins. “6th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke.”
Salman Haq, M Tavakol, Larry H Bernstein, Jerard Kneifati-Hayek, Madeleine Schlefer, Steven Silber, Terrence Sacchi, Joseph Pima
Circulation 2005; 111(20):e313-313
ICID: 939931
Article type: Original article
Earlier Articles
1. A simplified nutrition screen for hospitalized patients using readily available laboratory and patient information.
Linda Brugler, Ana K Stankovic, Madeleine Schlefer, Larry Bernstein
Nutrition 2005; 21(6):650-658
ICID: 825623
Article type: Original article
2. Minor elevations in troponin T values enhance risk assessment in emergency department patients with suspected myocardial ischemia: analysis of novel troponin T cut-off values.
Stuart W Zarich, Keith Bradley, Inder Dip Mayall, Larry H Bernstein
Clin Chim Acta 2004; 343(1-2):223-229
ICID: 825515
Article type: Original article
3. The role of visceral protein markers in protein calorie malnutrition.
Linda Brugler, Ana Stankovic, Larry Bernstein, Frederick Scott, Julie O’Sullivan-Maillet
Clin Chem Lab Med 2002; 40(12):1360-1369
ICID: 636207
Article type: Original article
4. GOLDmineR: improving models for classifying patients with chest pain.
Larry Bernstein, Keith Bradley, Stuart Zarich
2002; 75(4):183-198
ICID: 825624
Article type: Original article
5. Transthyretin: its response to malnutrition and stress injury. clinical usefulness and economic implications.
L Bernstein, Y Ingenbleek
Clin Chem Lab Med 2002; 40(12):1344-1348
ICID: 636205
Article type: Original article
6. Prediction of respiratory distress syndrome using the Abbott FLM-II amniotic fluid assay.
Lawrence A Kaplan, John F Chapman, Jay L Bock, Edward Santa Maria, Sanda Clejan, David J Huddleston, Roberta G Reed, Larry H Bernstein, Jonathan Gillen-Goldstein
Clin Chim Acta 2002; 326(1-2):61-68
ICID: 825512
Article type: Original article
7. Impact of troponin T determinations on hospital resource utilization and costs in the evaluation of patients with suspected myocardial ischemia.
S Zarich, K Bradley, J Seymour, W Ghali, A Traboulsi, I D Mayall, L Bernstein
Am J Cardiol 2001; 88(7):732-736
ICID: 825626
Article type: Original article
8. Nutrition and metabolism: the essentials for health vs illness.
Larry Bernstein
JOURNAL OF CLINICAL LIGAND ASSAY 2000; 23(2):96-97
ICID: 845478
Article type: Editorial
9. The five-year evolution of a malnutrition treatment program in a community hospital.
L Brugler, M J DiPrinzio, L Bernstein
Jt Comm J Qual Improv 1999; 25(4):191-206
ICID: 562389
Article type: Original article
10. Evaluating a new graphical ordinal logit method (GOLDminer) in the diagnosis of myocardial infarction utilizing clinical features and laboratory data.
L H Bernstein, A Qamar, C McPherson, S Zarich
1999; 72(4):259-268
ICID: 825617
Article type: Original article
11. The nutritionally dependent adaptive dichotomy (NDAD) and stress hypermetabolism
Yves Ingenbleek, Larry Bernstein
JOURNAL OF CLINICAL LIGAND ASSAY 1999; 22(3):259-267
ICID: 841561
Article type: Original article
12. Diagnosis of myocardial infarction: integration of serum markers and clinical descriptors using information theory.
L H Bernstein, A Qamar, C McPherson, S Zarich, R Rudolph
1999; 72(1):5-13
ICID: 825618
Article type: Original article
13. Nutrition-disease interactions : malnutrition and stress hypermetabolism
Larry Bernstein, Yves Ingenbleek
J Clin Ligand Assay 1999; 22(3):253-258
ICID: 841579
Article type: Editorial
14. The stressful condition as a nutritionally dependent adaptive dichotomy.
Y Ingenbleek, L Bernstein
Nutrition 1999; 15(4):305-320
ICID: 627568
Article type: Original article
15. The Goldman algorithm revisited: prospective evaluation of a computer-derived algorithm versus unaided physician judgment in suspected acute myocardial infarction.
A Qamar, C McPherson, J Babb, L Bernstein, M Werdmann, D Yasick, S Zarich
Am Heart J 1999; 138(4 Pt 1):705-709
ICID: 825629
Article type: Original article
16. Outcomes research is the fifth discipline of the fifth generation of managed care: utility of a single troponin-T.
A Qamar, L H Bernstein, S Zarich
1998; 12(2):80-86
ICID: 825620
Article type: Original article
17. Practice guideline for cardiac profiling.
L H Bernstein
Am J Clin Pathol 1997; 108(6):695-6
ICID: 224663
Article type: Letter/Correspondence
18. The Bridgeport Hospital experience with autologous transfusion in orthopedic surgery.
L H Bernstein, M Coles, A Granata
Orthopedics 1997; 20(8):677-680
ICID: 825509
Article type: Review article
19. Disease treatment or disease management? A misleading dichotomy.
L H Bernstein
Am Clin Lab 1997; 16(10):6-8
ICID: 825510
Article type: Editorial
20. Interpretation of Diagnostic Tests: A Synopsis of Laboratory Medicine, 5th ed., Jacques Wallach. Boston. Little, Brown and Company. (Book Review).
Larry Bernstein
Clin Chem 1993; 39(3):922-923
ICID: 845483
Article type: Letter/Correspondence
21. Determination of malnutrition in hospitalized patients with the use of a group-based reference.
A M Spiekerman, R A Rudolph, L H Bernstein
Arch Pathol Lab Med 1993; 117(2):184-186
ICID: 825521
Article type: Original Article
22. Diagnostic efficiency of carcinoembryonic antigen and CA125 in the cytological evaluation of effusions.
M M Pinto, L H Bernstein, R A Rudolph, D A Brogan, M Rosman
Arch Pathol Lab Med 1992; 116(6):626-631
ICID: 825503
Article type: Original article
23. Medically significant concentrations of prostate-specific antigen in serum assessed.
L H Bernstein, R A Rudolph, M M Pinto, N Viner, H Zuckerman
Clin Chem 1990; 36(3):515-518
ICID: 825497
Article type: Original article
24. What constitutes a laboratory quality monitoring program?
L H Bernstein
Qual Assur Util Rev 1990; 5(3):95-99
ICID: 825501
Article type: Original article
25. Diagnosis of acute myocardial infarction from two measurements of creatine kinase isoenzyme MB with use of nonparametric probability estimation.
L H Bernstein, I J Good, G I Holtzman, M L Deaton, J Babb
Clin Chem 1989; 35(3):444-447
ICID: 825570
Article type: Original article
26. Usefulness of data on albumin and prealbumin concentrations in determining effectiveness of nutritional support.
L H Bernstein, C J Leukhardt-Fairfield, W Pleban, R Rudolph
Clin Chem 1989; 35(2):271-274
ICID: 825610
Article type: Original article
27. Anion-exchange chromatographic determination of LD-1 and LD-2.
E Sachs, L H Bernstein
Clin Chem 1988; 34(10):0-2167
ICID: 825495
Article type: Letter/Correspondence
28. The lab’s role in nutritional assessment of patients.
L H Bernstein
MLO Med Lab Obs 1988; 20(4):25-27
ICID: 825567
Article type: Letter/Correspondence
29. Information induction for predicting acute myocardial infarction.
R A Rudolph, L H Bernstein, J Babb
Clin Chem 1988; 34(10):2031-2038
ICID: 825568
Article type: Review article
30. Performance evaluation: Lytening 1 analyzer compared with the Astra 8.
E Sachs, B Sachs, L H Bernstein
Clin Chem 1988; 34(7):0-1515
ICID: 825604
Article type: Letter/Correspondence
31. Analytical evaluation of the Ministat-s analyzer.
E Sachs, B Sachs, L H Bernstein
Clin Chem 1988; 34(10):2162-2163
ICID: 825608
Article type: Letter/Correspondence
32. Carcinoembryonic antigen in effusions. A diagnostic adjunct to cytology.
M M Pinto, L H Bernstein, D A Brogan, E M Criscuolo
Acta Cytologica 1987; 31(2):113-118
ICID: 825557
Article type: Original article
33. Enteral nutrition practices: similarities and differences between dietitians and physicians in Connecticut.
M Feitelson, P Fitz, S Rovezzi-Carroll, L H Bernstein
J Am Diet Assoc 1987; 87(10):1363-1368
ICID: 825651
Article type: Original article
34. Tube feeding utilization: a quality of care review.
M Feitelson, L H Bernstein, W E Pleban
J Am Diet Assoc 1987; 87(1):73-74
ICID: 825489
Article type: Letter/Correspondence
35. Correlation studies for whole blood vs plasma with the “Vision” analyzer.
E Sachs, B Sachs, L H Bernstein
Clin Chem 1987; 33(7):0-1268
ICID: 825491
Article type: Letter/Correspondence
36. Immunoradiometric assay of CA 125 in effusions. Comparison with carcinoembryonic antigen.
M M Pinto, L H Bernstein, D A Brogan, E Criscuolo
Cancer 1987; 59(2):218-222
ICID: 825555
Article type: Original article
37. Two methods compared for measuring LD-1/total LD activity in serum.
L H Bernstein, P Scinto
Clin Chem 1986; 32(5):792-796
ICID: 825581
Article type: Original article
38. Protein markers of nutrition status as related to sex and age.
E Sachs, L H Bernstein
Clin Chem 1986; 32(2):339-341
ICID: 825535
Article type: Original article
39. Statistical analysis of the stability of the standard curve for some Syva EMIT assays.
G V Zvaigzne, D A Brogan, L H Bernstein
Clin Chem 1986; 32(3):437-440
ICID: 825537
Article type: Original article
40. Lactate dehydrogenase isoenzyme-1/total ratio: accurate for determining the existence of myocardial infarction.
J Adan, L H Bernstein, J Babb
Clin Chem 1986; 32(4):624-628
ICID: 825540
Article type: Original article
41. Part A reimbursement: what is your role in medical quality assurance?
L H Bernstein, G M Kleinman, G L Davis, M Chiga
Pathologist 1986; 40(4):24-29
ICID: 825519
Article type: Letter/Correspondence
42. Moving lab revenues and costs outside the hospital.
L H Bernstein, G Davis
MLO Med Lab Obs 1985; 17(8):70-73
ICID: 825612
Article type: Editorial
43. Predicting the costs of laboratory testing.
L H Bernstein
Pathologist 1985; 39(2):19-21
ICID: 825584
Article type: Original article
44. An analysis of laboratory workload and physician test use.
L H Bernstein
Pathologist 1985; 39(6):35-39
ICID: 825561
Article type: Original article
45. Reorganizing for optimum efficiency.
L H Bernstein
Pathologist 1985; 39(6):25-30
ICID: 825586
Article type: Review article
46. The unordered test: cost of the benefit vs. benefit of the cost.
J W Winkelman, L H Bernstein
Pathologist 1985; 39(7):12-16
ICID: 825563
Article type: Original article
47. Urinary adenylate kinase activity as a predictor of renal allograft crises.
L H Bernstein, P J Russell, J M Horenstein
Clin Chem 1985; 31(7):1151-1154
ICID: 825588
Article type: Original article
48. Can peak CK-MB segregate patients with acute myocardial infarction into different outcome classes?
John Adan, Larry Bernstein, Joseph Babb
Clin Chem 1985; 31(2):996-997
ICID: 844986
Article type: Short communication
49. Product lines: the new world of DRG testing.
L H Bernstein
MLO Med Lab Obs 1985; 17(7):34-39
ICID: 825564
Article type: Letter/Correspondence
50. Linearity of results by low-concentration glucose strips evaluated.
R Herzlinger, S Eustice, L H Bernstein
Clin Chem 1985; 31(11):0-1925
ICID: 825566
Article type: Short communication
51. Managing and reducing lab costs.
L H Bernstein, G Davis, T Pelton
MLO Med Lab Obs 1984; 16(2):53-56
ICID: 825613
Article type: Editorial
52. Cutting laboratory costs: where we are most likely to succeed.
L H Bernstein, E Sachs
Pathologist 1984; 38(12):795-798
ICID: 825614
Article type: Editorial
53. Urinary adenylate kinase and urinary tract infections.
L H Bernstein, J M Horenstein, P J Russell
J Clin Microbiol 1983; 18(3):578-584
ICID: 825559
Article type: Original article
54. Training pathologist consultants
Larry Bernstein
Am J Clin Pathol 1983; 79(1):270-270
ICID: 844984
Article type: Letter/Correspondence
55. Diseconomies of scale: An analysis of hospital laboratories
Larry Bernstein
Clin Chem 1983; 29(2):1257-1258
ICID: 844985
Article type: Short communication
56. Serum lactate dehydrogenase isoenzyme-1: effect of time of sampling and total serum LD activity on diagnostic efficacy.
L H Bernstein, G Reynoso
Clin Chem 1983; 29(3):589-590
ICID: 825547
Article type: Letter/Correspondence
57. Creatine kinase B-subunit activity in serum in cases of suspected myocardial infarction: a prediction model based on the slope of MB increase and percentage CK-MB activity.
L H Bernstein, G Reynoso
Clin Chem 1983; 29(3):590-592
ICID: 825549
Article type: Letter/Correspondence
58. The cytoplasmic malate dehydrogenase in neoplastic tissues; presence of a novel isoenzyme?
M B Grisham, L H Bernstein, J Everse
Br J Cancer 1983; 47(5):727-731
ICID: 825551
Article type: Original article
59. Preliminary use of linear discriminant function to predict success or failure of kidney transplant.
L H Bernstein, P J Russell, W D Foster
Ann Clin Lab Sci 1982; 12(1):60-67
ICID: 825545
Article type: Original article
60. Reserve bilirubin binding capacity measured by absorbance deviation at saturation of primary albumin binding sites.
R C Banagale, L H Bernstein
Res Commun Chem Pathol Pharmacol 1982; 38(3):463-479
ICID: 825600
Article type: Original article
61. Reserve albumin capacity for bilirubin measured by Sephadex absorption (SA) and by absorbance deviation (AD) at saturation of primary albumin-binding sites
Raul Banagale, Larry Bernstein, JJ Bray
Pediatr Res 1981; 15(1):476-476
ICID: 844982
Article type: Short communication
62. An evaluation of the immunochemical LD1 method in routine clinical practice.
R Belding, Larry Bernstein, Gustavo Reynoso
Clin Chem 1981; 27(10):1027-1028
ICID: 844981
Article type: Short communication
63. Nonparametric detection scheme for myocardial infarction
Larry Bernstein, Chris Tsokos, John Turner
J Med Syst 1978; 2(3):203-212
ICID: 825655
Article type: Original article
64. Substrate inhibition of the mitochondrial and cytoplasmic malate dehydrogenases.
L H Bernstein, M B Grisham, K D Cole, J Everse
J Biol Chem 1978; 253(24):8697-8701
ICID: 825513
Article type: Original article
65. Studies on the mechanism of the malate dehydrogenase reaction.
L H Bernstein, J Everse
J Biol Chem 1978; 253(24):8702-8707
ICID: 825518
Article type: Original article
66. Automated kinetic determination of lactate dehydrogenase isoenzymes in serum.
L H Bernstein
Clin Chem 1977; 23(10):1928-1930
ICID: 825616
Article type: Original article
67. Determination of the isoenzyme levels of lactate dehydrogenase.
L H Bernstein, J Everse
Methods Enzymol 1975; 41: 47-52
ICID: 825516
Article type: Original article
68. Detection of cardiac damage using a steady state assay for lactate dehydrogenase isoenzymes in serum.
L H Bernstein, J Everse, N Shioura, P J Russell
J Mol Cell Cardiol 1974; 6(4):297-315
ICID: 825597
Article type: Original article
69. Methoxyfluorane nephrotoxicity: report of a case with electron microscopic observations
Harry Powell, R Garrett, Larry Bernstein, R Mazze
Human Pathology 1974; 3(1):359-363
ICID: 844980
Article type: Case report
70. Adenylate kinase in human tissue. II. Serum adenylate kinase and myocardial infarction.
L H Bernstein, J M Horenstein, H D Sybers, P J Russell
J Mol Cell Cardiol 1973; 5(1):71-85
ICID: 825590
Article type: Original article
71. Lacticdehydrogenase isoenzymes in lens and cornea
Larry Bernstein, Michael Kerrigan, Harry Maisel
Exp Eye Res 1965; 5(3):999-1005
ICID: 844979
Article type: Original article
72. At the bedside: Measuring patient outcomes.
Fisher, W. P., Jr., Bernstein, L. H., Qamar, A., Babb, J., Rypka, E. W., & Yasick, D. (2002, February). Advance for Administrators of the Laboratory, 11(2), 8, 10.
73. Linking costs and quality improvement to clinical outcomes through added value.
Castaneda-Mendez K, Bernstein LH.
J Healthcare Quality 1997;19:11-16.
Original article
List of my books
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Major Presentations
Name of conference / location
1. Dartmouth-Hitchcock Department of Pathology Seminar
2008-02-11
Lebanon, NH, USA
Participation:
active – invited speaker: Clinical Pathology and Clinical Outcomes Evaluation for Evidence Based Decision Support
2. Society of Critical Care Medicine’s Annual Meeting
2008-02-08
xxxxx, USA
Participation:
active – other: Validation of cardiac output measurements utilizing arterial pulse contour
active – other: C-Reactive protein as a prognostic tool for patients with systemic inflammatory response syndrome secondary to sepsis
active – other: Procalcitonin as a marker for early identification of sepsis—a pilot study.
3. American College of Chest Physicians
2007-10-07
XXX, USA
Participation:
active – other: The effect of mechanical ventilation on NT-ProBNP Level: A pilot study. Chest 2007 Oct;132(4):456S.
4. 2007 American Society for Clinical Pathology Meeting
2007-09-07
New Orleans, LA, USA
Participation:
active – poster presentation: Renal Insufficiency in Predicting NT-ProBNP level elevation (RIPPLE): A TriHospital Study
active – poster presentation: Effects of Comorbidities on Cardiac Troponin-T Levels
active – poster presentation: A NOVEL ENHANCEMENT IN THE DIAGNOSTIC PERFORMANCE OF TROPONINS
active – poster presentation: C-Reactive Protein and SIRS
5. 2007 Annual Meeting of American Association for Clinical Chemistry (AACC)
2007-07-15 – 2008-03-20
San Diego, CA, USA
Participation:
active – poster presentation: Renal Insufficiency in Predicting NT-ProBNP level elevation (RIPPLE): A TriHospital Study
active – poster presentation: Effective use of C-reactive protein in the diagnosis of sepsis
active – poster presentation: Anemia as a Predictor of NT-ProBNP level elevation (APPLE) without RenalInsufficiency: A TriHospital Study
active – poster presentation: What is the best approximation of reference normal for NT-proBNP? Clinical Levels for Enhanced Assessment of NT-proBNP (CLEAN)
active – poster presentation: Evaluation of D-dimer in diagnosing DVTs
active – poster presentation: Predicting Outcome in the Critically Ill with Transthyretin (POCIT) Study
active – poster presentation: A Model for Automated-Screening of Thalassemia in Hematology (MATH study)
6. Annual Scientific Assembly, American College of Chest Physicians
2006-10-06
XXX, USA
Participation:
active – other: Transthyretin as a marker to assess malnutrition in critically ill patients. Chest 2006 Oct;130(4):216S.
active – other: Serum cortisol level and coronary artery bypass surgery patients. Abstract of poster presentation at meeting of ACCP, Salt Lake City, Utah, October 25, 2006. 230; Abstract no.188S. http://meeting.chestjournal.org/cgi/reprint/130/4/188S- Accessed April 9, 2007.
7. 2006 Scientific Sessions of American Heart Association
2006-03-08
XXXX, USA
Participation:
active – other: Anemia as an independent predictor of elevated Pro-BNP levels in patients without evidence of heart failure and normal renal function. Circulation 2006 Oct
8. Academy of Emergency Medicine
2006-03-08
xxxx, USA
Participation:
active – other: Comparison of test characteristics of cardiac troponin T in patients with normal renal function and chronic renal failure evaluated in the emergency department. Acad Emerg Med. 2006
9. American College of Chest Physicians
2005-10-08
Montreal, Canada
Participation:
active – other: Perioperative use of amiodarone in cardiac surgery patients to achieve normal sinus rhythm upon discharge. Abstract of
10. Annual Scientific Session American College of Cardiology 2006
2005-10-04
XXX, USA
Participation:
active – poster presentation: Anemia as an independent predictor of elevated N-terminal proBNP
11. Toward an Electronic Patient Record
2001-05-12
Boston, MA, USA
Participation:
active – invited speaker: Goldminer: improving models for classifying data. Chest pain example.
12. 2000 Scientific Sessions of American Heart Association
2000-11-12 – 2000-11-15
New Orleans, USA
Participation:
active – oral presentation: Value of troponin T in improving hospital resource utilization in suspected myocardial ischemia
13. Toward an Electronic Patient Record (TEPR)
2000-05-11
San Francisco, CA, USA
Participation:
active – invited speaker: Laboratory integration with the HER for clinical outcomes.
14. 20th Annual Congress of Quebec Society of Clinical Biochemists
1999-10-23 – 1999-10-26
Saint-Adele, Canada
Participation:
active – oral presentation: Malnutrition and Health outcomes
15. Clinical Laboratory Management Association
1997-08-16
Toronto, Canada
Participation:
active – invited speaker: Outcomes research is the fifth discipline on the fifth generation of managed care. CLMA Outcomes Symposium.
active – oral presentation: Hospital laboratories: An untapped gold mine for combining positive outcomes, efficacious cost savings, and increased net income in the managed care environment. INCSTAR
16. NATIONAL MEETING OF THE AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY
1997-07-29
Atlanta, GA, USA
Participation:
active – chairperson of the session: Outcomes nutritional measurement and management using current lab analytical technology. Nutrition Chemistry \’97: Effective use of the hospital laboratory for positive outcomes and cost savings through nutrition screening programs.
17. 1997 Frontiers in Diagnostics Conference
1997-06-22 – 1997-06-24
Atlanta, USA
Participation:
active – oral presentation: The impact of managed care on diagnostic testing
18. 17th Ross Roundtable
1996-06-13 – 2008-03-15
Sanibel Island, FL, USA
Participation:
active – other: Outcomes Seminar in Nutrition Management
19. Toward an Electronic Patient Record
1996-05-16
San Diego, CA, USA
Participation:
active – invited speaker: Communication requirements for laboratory information systems integrated with medical information systems, in Laboratory information systems, Arden Forrey, Chair, TEPR \’96
20. Consortium of Laboratory Professionals
1996-04-27
Indianapolis, IN, USA
Participation:
active – invited speaker: Lab assessment of nutritional status
21. Wayne State University Department of Pathology Seminar
1996-04-23
Detroit, MI, USA
Participation:
active – invited speaker: Clinical pathologist\’s role in managed care
22. American Society for Parenteral and Enteral Nutrition
1995-01-07
San Diego, Ca, USA
Participation:
active – invited speaker: Postgraduate course #12: Incorporating the laboratory into quality management programs;
active – invited speaker: Pharmacy workshop: Nutrition therapy: LOS and outcome predictors
23. 10th World Congress of Gastroenterologists
1994-10-04
Los Angeles, USA
Participation:
active – oral presentation: Skeleton in the Closet – 20 years later, Oct 1, 1994 (10th World GI Congress) – Relationship of nutrition status indicators to length of hospital stay (symposium);
active – poster presentation: An information approach to malnutrition (P-24); & Prealbumin in nutrition evaluation (P-16).
24. American College of Nutrition Meeting
1993-05-22
XXX, USA
Participation:
active – oral presentation: Evaluating and monitoring nutrition status
25. American Association for Clinical Chemistry
1993-03-16
New York, NY, USA
Participation:
active – chairperson of the session: Workshop- Converting laboratory data to information (with Eugene W. Rypka and Rosser A. Rudolph)
26. 14th Ross Roundtable
1993-03-07
Savannah, GA, USA
Participation:
active – chairperson of the session: Financial impact of hospital malnutrition
27. Seminar, University of New Mexicao
1993-02-20
Albuquerque, NM, USA
Participation:
active – other: Truth table comprehension: A seminar (with R. Rudolph, E. Rypka, M. Chiga).
28. AHSR/FSHR Annual Meeting
1992-06-07
Chicago, IL, USA
.
active – poster presentation: Getting the most out of data. Expectations for Outcomes Research and Guidelines: Can they be met?
| Generating Evidence Based Interpretation of Hematology Screens via Anomaly Characterization.Gil David, Larry H Bernstein, Ronald CoifmanOpen Clinical Chemistry Journal 2011; 4 (1):10-16. 1874-2416/11 2011 Bentham OpenICID: 939928We propose a simple, workable algorithm that provides assistance for interpreting any set of data from the screen of a blood analysis with high accuracy, reliability, and inter-operability with an electronic medical record. This has been made possible at least recently as a result of advances in mathematics, low computational costs, and rapid transmission of the necessary data for computation.The Transthyretin Inflammatory State ConundrumLarry H. BernsteinCurrent Nutrition & Food Science, 2012, 8, 00-00Keywords: Tranthyretin (TTR), systemic inflammatory response syndrome (SIRS), protein-energy malnutrition (PEM), C- reactive protein, cytokines, hypermetabolism, catabolism, repair.There are a number of physiologic changes associated with SIRS and the injury/repair process that will affect TTR and will be put in the context of this review. In the context of an ICU setting, the contribution of TTR is significant. Despite the complexity of the situation, TTR is not to be considered a test “for all seasons”. In the context of age, prolonged poor meal intake, chronic or acute illness, TTR needs to be viewed in a multivariable lens, along with estimated lean body mass, C-reactive protein, the absolute lymphocyte count, presence of neutrophilia, and perhaps procalcitonin if there is remaining uncertainty. Furthermore, the reduction of risk of associated complication requires a systematized approach to timely identification, communication, and implementation of a suitable treatment plan.
Manuscript Number: NUT-12-8802 (31 May 2012 ■ 1-9) Title: The Automated Malnutrition Assessment Article Type: Original Article Accepted 29 April 2012. www.nutritionjrnl.com. Nutrition (2012), doi:10.1016/j.nut.2012.04.017. Keywords: Network Algorithm; unsupervised classification; malnutrition screening; protein energy malnutrition (PEM); malnutrition risk; characteristic metric; characteristic profile; data characterization; non-linear differential diagnosis Corresponding Author: Dr Larry Howard Bernstein, MD First Author: Gil David, PhD Order of Authors: Gil David, PhD; Larry Howard Bernstein, MD; Ronald R Coifman, PhD We propose an automated nutritional assessment (ANA) algorithm that provides a method for malnutrition risk prediction with high accuracy and reliability. The problem of rapidly identifying risk and severity of malnutrition is crucial for minimizing medical and surgical complications. These are not easily performed or adequately expedited. We characterized for each patient a unique profile and mapped similar patients into a classification. We also found that the laboratory parameters were sufficient for the automated risk prediction. Metabolomics, Metabonomics and Functional Nutrition: The Next Step in Nutritional Metabolism and Biotherapeutics Larry H. Bernstein 2012 Lifescience Global. ISSN: 2223-3806 / E-ISSN: 1927-5951/12 Keywords: Genomics, Functional genomics, Proteomics, Metabolic Pathways, Metabolome, Metabonomics, Metabolic Syndrome, Inflammatory Process, Cancer, Iron Metabolism, Obesity, Fat Metabolism. Metabolomics is a part of an integrated approach to biological sciences that is grouped with an “OMICS” family of genomics, proteomics, transcriptomics, translational medicine, and pharmacogenomics. This is a challenge to our knowledge comprehension with an explosive development in the computational technology for modeling biological systems and studying the interaction between the genome, the ribosome, protein synthesis, protein folding, and metabolic regulation |
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Publications
| Converting Hematology Based Data into an Inferential InterpretationLarry H. Bernstein, Gil David, James Rucinski and Ronald R. Coifman In Hematology – Science and Practice, Chapter 22, pp 541-552 2012. InTech Open Access Publ. Croatia.Manuscript Number: CLB-12- (in press)Title: The Increasing Role for the Laboratory in Nutritional AssessmentArticle Type: EditorialSection/Category: Clinical Investigation Accepted 22 May 2012. http://www.elsevier.com/locate/clinbiochem. Clin Biochem (2012), doi:10.1016/j.clinbiochem.2012.05.024Keywords: Protein Energy Malnutrition; Nutritional Screening; Laboratory TestingCorresponding Author: Dr. Larry Howard Bernstein, MDCorresponding Author’s Institution: New York Methodist HospitalFirst Author: Larry Howard Bernstein, MDOrder of Authors: Larry Howard Bernstein, MDAbstract: The laboratory role in nutritional management of the patient has seen remarkable growthwhile there have been dramatic changes in technology over the last 25 years, and it is bound to betransformative in the near term. This editorial is an overview of the importance of the laboratory as an active participant in nutritional care. Manuscript Number: CLB-12-008.. (in press) Keywords: Registered dietitian, length of stay, nutritionally high-risk, protein-energy malnutrition, coordinated nutritional care-plan, early identification Corresponding Author: Dr. Larry Howard Bernstein, MD Corresponding Author’s Institution: New York Methodist Hospital First Author: Christopher Lee, MS Authors: Christopher Lee, MS; James Rucinski, MD; Larry Howard Bernstein, MD Abstract: Objective: This study investigated identification and treatment of patients at-risk for malnutrition and extended inpatient length of stay. Design: Data were collected retrospectively from the medical records for a period of six months. The records were reviewed for: (1) adherence to RD recommendation, (2) decreasing serum albumin during hospital stay, (3) length of hospital stay, (4) readmission within 30 days, (5) age, (6) gender, (7) past medical history, (8) primary and secondary diagnoses, (9) the presence or absence of a diet order and (10) medications. Subjects and participants: Medical records were reviewed for diagnoses associated with nutrition-related complications. Patient’s records were excluded for length of stay less than four days, or in-hospital death. Results: The mean LOS was ten days shorter when the advice was followed (p = 0.0074). Conclusions: Patients at high nutritional risk have a shorter LOS and have fewer complications when the RD advice is followed.
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| – C-Reactive Protein for the Enhanced Evaluation of the Systemic Inflammatory Response Syndrome (SIRS) Gitta Pancer, Ester Engelman, Farhana Hoque, Mohammed Alam, James Rucinski, LarryH BernsteinOpen Clinical Chemistry Journal 2010; 3(3):90-98ICID: 939929Article type: Original article |
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| – Calorimetry and metabolic knowledge. Larry H BernsteinNutrition 2010; 26(10):0-951ICID: 939933Article type: Editorial |
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| – Reducing pressure ulcer risks in activity-restricted patients: a national imperative. Larry H BernsteinNutrition 2010; 26(9):0-861ICID: 939935Article type: Editorial |
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| – Effect of renal function loss on NT-proBNP level variations. | ||||
Larry H Bernstein, Michael Y Zions, Salman A Haq, Stuart Zarich, James Rucinski, Bette Seamonds,
Stanley Berger, Daniel Y Lesley, William Fleischman, John F Heitner
Clin Biochem 2009; 42(10-11):1091-1098
ICID: 937529
Article type: Original article
-The Automated Nutrition Score is a data-driven extension of continuous quality improvement.
Larry H Bernstein
Nutrition 2009; 25(3):316-317
ICID: 939934
Validation and Calibration of the Relationship between Granulocyte Maturation and the Septic State
Larry H Bernstein and James Rucinski
accepted July 29, 2011
Clin Chem Lab Med 2011;49(x):xxx-xxx _ 2011 by Walter de Gruyter • Berlin • Boston.
DOI 10.1515/CCLM.2011.688
Article Type: Original Article
| – Enhancing the diagnostic performance of troponins in the acute care setting. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Salman A Haq, Morteza Tavakol, Steven Silber, Larry Bernstein, Jerard Kneifati-Hayek, MadeleineSchleffer, Lesan T Banko, John F Heitner, Terrence J Sacchi, Joseph A PumaJ Emerg Med 2008; 0 0ICID: 937619Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Transthyretin as a marker to predict outcome in critically ill patients. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Arun Devakonda, Liziamma George, Suhail Raoof, Adebayo Esan, Anthony Saleh, Larry H Bernstein | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Clin Biochem 2008; 41(14-15):1126-1130ICID: 939927Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The effect of mechanical ventilation on NT-ProBNP Level: A pilot study | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| A Bishay, A Esan, A Amchentsev, L Irugulapati, R Patel, S Adoni, Larry H Bernstein, LiziammaGeorge, Suhail RaoofChest 2007; 132(4):S456-456ICID: 939944Article type: Other | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – A model for automated screening of thalassemia in hematology (math study). | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Jerard Kneifati-Hayek, William Fleischman, Larry H Bernstein, Anthony Riccioli, Rita BellevueLab Hematol 2007; 13(4):119-123ICID: 843950Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The systemic inflammatory response syndrome C-reactive protein and transthyretin conundrum. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Larry H BernsteinClin Chem Lab Med 2007; 45(11):0ICID: 939932Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Critical Care: Outcomes. Transthyretin as a marker to assess malnutrition in critically ill patients | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Arun Devakonda, A Esan, Liziamma George, Suhail Raoof, LarryH BernsteinChest 2006; 130(4):S216-216ICID: 939945Article type: Other | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Anemia as an independent predictor of elevated Pro-BNP levels in patients without evidence ofheart failure and normal renal function. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Salman Haq, Mohammed Alam, LarryH Bernstein, L Banko, B Saul, L Lee, Terrence Sacchi, JohnHeitnerCirculation 2006; 114(18):II771-772ICID: 939946Article type: Other | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – . Serum cortisol level and coronary artery bypass surgery patients. Abstract of poster presentation at | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| meeting of ACCP, Salt Lake City, Utah, October 25, 2006. 230; Abstract no.188S.http://meeting.chestjournal.org/cgi/reprint/130/4/188S- Accessed April 9, 2007. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| N Mansuroglu, M Ali, Charles Oribabor, V Matatov, LarryH Bernstein, W Elzomoor, W Tinker, MNazares, D Koloyian, L Lee, Anthony TortolaniChest 2006; 130(4):S188-188ICID: 939966Article type: Other | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – . Comparison of test characteristics of cardiac troponin T in patients with normal renal function andchronic renal failure evaluated in the emergency department. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Steve Silber, Lawrence Melniker, Elizabeth Haines, LarryH BernsteinAcademic Emergency Medicine 2006; 13(5):S1186-187ICID: 939943Article type: Other | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Cardiac Surgery Variables Affecting Outcomes: Perioperative use of amiodarone in cardiac surgerypatients to achieve normal sinus rhythm upon discharge. Abstract of presentation at meeting of ACCP,Montreal, Canada, 2005. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| N Mansuroglu, Charles Oribabor, A Tinker, A Mariano, R Slepian, F Gebreab, LarryH Bernstein, LLee, Anthony TortolaniChest 2005; 128(4):S180-180ICID: 939967Article type: Other | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The ACC/ESC Recommendation for 99th Percentile of the Reference NormalTroponin IOverestimates the Risk of an Acute Myocardial Infarction: a novel enhancement in the diagnosticperformance of troponins. “6th Scientific Forum on Quality of Care and Outcomes Research inCardiovascular Disease and Stroke.” | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Salman Haq, M Tavakol, LarryH Bernstein, Jerard Kneifati-Hayek, Madeleine Schlefer, Steven Silber,Terrence Sacchi, Joseph PimaCirculation 2005; 111(20):e313-313ICID: 939931Article type: Other | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – A simplified nutrition screen for hospitalized patients using readily available laboratory and patientinformation. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Linda Brugler, Ana K Stankovic, Madeleine Schlefer, Larry BernsteinNutrition 2005; 21(6):650-658ICID: 825623Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Minor elevations in troponin T values enhance risk assessment in emergency department patientswith suspected myocardial ischemia: analysis of novel troponin T cut-off values. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stuart W Zarich, Keith Bradley, Inder Dip Mayall, Larry H BernsteinClinica Chimica Acta 2004; 343(1-2):223-229ICID: 825515Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Effectiveness of a multidisciplinary quality improvement initiative in reducing door-to-balloon times inprimary angioplasty. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stuart W Zarich, Rajesh Sachdeva, Robert Fishman, Michael J Werdmann, Margaret Parniawski,Lawrence Bernstein, Michelle DilellaJ Interv Cardiol 2004; 17(4):191-195ICID: 845715Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The role of visceral protein markers in protein calorie malnutrition. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Linda Brugler, Ana Stankovic, Larry Bernstein, Frederick Scott, Julie O’Sullivan-MailletClin Chem Lab Med 2002; 40(12):1360-1369ICID: 636207Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – GOLDmineR: improving models for classifying patients with chest pain. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Larry Bernstein, Keith Bradley, Stuart Zarich2002; 75(4):183-198ICID: 825624Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Transthyretin: its response to malnutrition and stress injury. clinical usefulness and economicimplications. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LH Bernstein, Y IngenbleekClin Chem Lab Med 2002; 40(12):1344-1348ICID: 636205Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Value of a single troponin T at the time of presentation as compared to serial CK-MB determinationsin patients with suspected myocardial ischemia. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Stuart W Zarich, Asad U Qamar, Michael J Werdmann, Lori S Lizak, Craig A McPherson, Larry HBernsteinClinica Chimica Acta 2002; 326(1-2):185-192ICID: 939930Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Prediction of respiratory distress syndrome using the Abbott FLM-II amniotic fluid assay. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lawrence A Kaplan, John F Chapman, Jay L Bock, Edward Santa Maria, Sanda Clejan, David JHuddleston, Roberta G Reed, Larry H Bernstein, Jonathan Gillen-GoldsteinClinica Chimica Acta 2002; 326(1-2):61-68ICID: 825512Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Impact of troponin T determinations on hospital resource utilization and costs in the evaluation ofpatients with suspected myocardial ischemia. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| S Zarich, K Bradley, J Seymour, W Ghali, A Traboulsi, I D Mayall, L BernsteinAm J Cardiol 2001; 88(7):732-736ICID: 825626Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| 1 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Nutrition and metabolism: the essentials for health vs illness. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH BernsteinJOURNAL OF CLINICAL LIGAND ASSAY 2000; 23(2):96-97ICID: 845478Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The five-year evolution of a malnutrition treatment program in a community hospital. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L Brugler, M J DiPrinzio, L BernsteinJt Comm J Qual Improv 1999; 25(4):191-206ICID: 562389Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The nutritionally dependent adaptive dichotomy (NDAD) and stress hypermetabolism | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Yves Ingenbleek, LarryH BernsteinJOURNAL OF CLINICAL LIGAND ASSAY 1999; 22(3):259-267ICID: 841561Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Nutrition-disease interactions : malnutrition and stress hypermetabolism | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH Bernstein, Yves IngenbleekJOURNAL OF CLINICAL LIGAND ASSAY 1999; 22(3):253-258ICID: 841579Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The stressful condition as a nutritionally dependent adaptive dichotomy. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Y Ingenbleek, LH BernsteinNutrition 1999; 15(4):305-320ICID: 627568Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Evaluating a new graphical ordinal logit method (GOLDminer) in the diagnosis of myocardialinfarction utilizing clinical features and laboratory data. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, A Qamar, C McPherson, S Zarich1999; 72(4):259-268ICID: 825617Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Diagnosis of myocardial infarction: integration of serum markers and clinical descriptors usinginformation theory. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, A Qamar, C McPherson, S Zarich, R Rudolph1999; 72(1):5-13ICID: 825618Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The Goldman algorithm revisited: prospective evaluation of a computer-derived algorithm versusunaided physician judgment in suspected acute myocardial infarction. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| A Qamar, C McPherson, J Babb, L Bernstein, M Werdmann, D Yasick, S ZarichAm Heart J 1999; 138(4 Pt 1):705-709 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| ICID: 825629Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Outcomes research is the fifth discipline of the fifth generation of managed care: utility of a singletroponin-T. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| A Qamar, L H Bernstein, S Zarich1998; 12(2):80-86ICID: 825620Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Practice guideline for cardiac profiling. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinAm J Clin Pathol 1997; 108(6):695-6ICID: 224663Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Time and muscle: A disease management perspective: Report of a conference on markers ofmyocardial damage. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH BernsteinAm Clin Lab 1997; 16(1):7-7ICID: 845481Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The Bridgeport Hospital experience with autologous transfusion in orthopedic surgery. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, M Coles, A GranataOrthopedics 1997; 20(8):677-680ICID: 825509Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Disease treatment or disease management? A misleading dichotomy. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinAm Clin Lab 1997; 16(10):6-8ICID: 825510Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Strategic considerations in clinical laboratory management: a laboratory leadership role in clinicalpathways. Establishing the laboratory’s direct contribution to the institution’s performance. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, F I Scott1997; 11(2):116-124ICID: 825554Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Bridgeport Hospital autologous blood donation experience from 1992 to 1996. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, M Coles, N Viner1996; 68(5-6):207-213ICID: 825506Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Effective resource management using a clinical and laboratory algorithm for chest pain triage. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L Bernstein, A M Spiekerman, A Qamar, J Babb1996; 10(2):143-152ICID: 825630Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Cholecystokinin-stimulated monocytes produce inflammatory cytokines and eicosanoids. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| M E Cunningham, T A Shaw-Stiffel, L H Bernstein, T J Tinghitella, R E Claus, D A Brogan, M AMcMillenAm J Gastroenterol 1995; 90(4):621-626ICID: 825533Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Relationship of nutritional markers to length of hospital stay. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinNutrition 1995; 11(2 Suppl):205-209ICID: 825505Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Amniotic fluid polarization of fluorescence and lecithin/sphingomyelin ratio decision criteriaassessed. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, R Stiller, C Menzies, M McKenzie, C Rundell1995; 68(3-4):101-117ICID: 825579Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Utilizing laboratory parameters to monitor effectiveness of nutritional support. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinNutrition 1994; 10(1):58-60ICID: 825576Article type: Short communication | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Effect of nutrition status and other factors on length of hospital stay after major gastrointestinalsurgery. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| T A Shaw-Stiffel, L A Zarny, W E Pleban, D D Rosman, R A Rudolph, L H BernsteinNutrition 1993; 9(2):140-145ICID: 825643Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Interpretation of Diagnostic Tests: A Synopsis of Laboratory Medicine, 5th ed., Jacques Wallach.Boston. Little, Brown and Company. (Book Review). | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH BernsteinClin Chem 1993; 39(3):922-923ICID: 845483Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Determination of malnutrition in hospitalized patients with the use of a group-based reference. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| A M Spiekerman, R A Rudolph, L H BernsteinArch Pathol Lab Med 1993; 117(2):184-186 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| ICID: 825521Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Financial implications of malnutrition. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, T A Shaw-Stiffel, M Schorow, R BrouilletteClin Lab Med 1993; 13(2):491-507ICID: 825530Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Diagnostic efficiency of carcinoembryonic antigen and CA125 in the cytological evaluation ofeffusions. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| M M Pinto, L H Bernstein, R A Rudolph, D A Brogan, M RosmanArch Pathol Lab Med 1992; 116(6):626-631ICID: 825503Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Medically significant concentrations of prostate-specific antigen in serum assessed. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, R A Rudolph, M M Pinto, N Viner, H ZuckermanClin Chem 1990; 36(3):515-518ICID: 825497Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – What constitutes a laboratory quality monitoring program? | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinQual Assur Util Rev 1990; 5(3):95-99ICID: 825501Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Usefulness of data on albumin and prealbumin concentrations in determining effectiveness ofnutritional support. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, C J Leukhardt-Fairfield, W Pleban, R RudolphClin Chem 1989; 35(2):271-274ICID: 825610Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Diagnosis of acute myocardial infarction from two measurements of creatine kinase isoenzyme MBwith use of nonparametric probability estimation. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, I J Good, G I Holtzman, M L Deaton, J BabbClin Chem 1989; 35(3):444-447ICID: 825570Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Performance evaluation: Lytening 1 analyzer compared with the Astra 8. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| E Sachs, B Sachs, L H BernsteinClin Chem 1988; 34(7):0-1515ICID: 825604Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Analytical evaluation of the Ministat-s analyzer. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| E Sachs, B Sachs, L H BernsteinClin Chem 1988; 34(10):2162-2163ICID: 825608Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Anion-exchange chromatographic determination of LD-1 and LD-2. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| E Sachs, L H BernsteinClin Chem 1988; 34(10):0-2167ICID: 825495Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The lab’s role in nutritional assessment of patients. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinMLO Med Lab Obs 1988; 20(4):25-27ICID: 825567Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Information induction for predicting acute myocardial infarction. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| R A Rudolph, L H Bernstein, J BabbClin Chem 1988; 34(10):2031-2038ICID: 825568Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Carcinoembryonic antigen in effusions. A diagnostic adjunct to cytology. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| M M Pinto, L H Bernstein, D A Brogan, E M CriscuoloActa Cytologica 1987; 31(2):113-118ICID: 825557Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Enteral nutrition practices: similarities and differences between dietitians and physicians inConnecticut. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| M Feitelson, P Fitz, S Rovezzi-Carroll, L H BernsteinJ Am Diet Assoc 1987; 87(10):1363-1368ICID: 825651Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Tube feeding utilization: a quality of care review. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| M Feitelson, L H Bernstein, W E PlebanJ Am Diet Assoc 1987; 87(1):73-74ICID: 825489Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Correlation studies for whole blood vs plasma with the “Vision” analyzer. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| E Sachs, B Sachs, L H BernsteinClin Chem 1987; 33(7):0-1268ICID: 825491Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Practice guideline for cardiac profiling (letter). | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH BernsteinAm J Clin Pathol 1987; 108(1):695-695ICID: 844983Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Immunoradiometric assay of CA 125 in effusions. Comparison with carcinoembryonic antigen. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| M M Pinto, L H Bernstein, D A Brogan, E CriscuoloCancer 1987; 59(2):218-222ICID: 825555Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Part A reimbursement: what is your role in medical quality assurance? | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, G M Kleinman, G L Davis, M ChigaPathologist 1986; 40(4):24-29ICID: 825519Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Protein markers of nutrition status as related to sex and age. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| E Sachs, L H BernsteinClin Chem 1986; 32(2):339-341ICID: 825535Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Statistical analysis of the stability of the standard curve for some Syva EMIT assays. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| G V Zvaigzne, D A Brogan, L H BernsteinClin Chem 1986; 32(3):437-440ICID: 825537Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Lactate dehydrogenase isoenzyme-1/total ratio: accurate for determining the existence ofmyocardial infarction. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| J Adan, L H Bernstein, J BabbClin Chem 1986; 32(4):624-628ICID: 825540Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Two methods compared for measuring LD-1/total LD activity in serum. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, P ScintoClin Chem 1986; 32(5):792-796ICID: 825581Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – An analysis of laboratory workload and physician test use. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinPathologist 1985; 39(6):35-39ICID: 825561Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The unordered test: cost of the benefit vs. benefit of the cost. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| J W Winkelman, L H BernsteinPathologist 1985; 39(7):12-16ICID: 825563Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Product lines: the new world of DRG testing. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinMLO Med Lab Obs 1985; 17(7):34-39ICID: 825564Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Linearity of results by low-concentration glucose strips evaluated. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| R Herzlinger, S Eustice, L H BernsteinClin Chem 1985; 31(11):0-1925ICID: 825566Article type: Short communication | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Moving lab revenues and costs outside the hospital. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, G DavisMLO Med Lab Obs 1985; 17(8):70-73ICID: 825612Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Predicting the costs of laboratory testing. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinPathologist 1985; 39(2):19-21ICID: 825584Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Reorganizing for optimum efficiency. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinPathologist 1985; 39(6):25-30ICID: 825586Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Urinary adenylate kinase activity as a predictor of renal allograft crises. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, P J Russell, J M HorensteinClin Chem 1985; 31(7):1151-1154ICID: 825588Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Can peak CK-MB segregate patients with acute myocardial infarction into different outcomeclasses? | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| John Adan, Larry H Bernstein, Joseph BabbClin Chem 1985; 31(2):996-997ICID: 844986Article type: Short communication | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Managing and reducing lab costs. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, G Davis, T PeltonMLO Med Lab Obs 1984; 16(2):53-56ICID: 825613Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Cutting laboratory costs: where we are most likely to succeed. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, E SachsPathologist 1984; 38(12):795-798ICID: 825614Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Urinary adenylate kinase and urinary tract infections. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, J M Horenstein, P J RussellJ Clin Microbiol 1983; 18(3):578-584ICID: 825559Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Serum lactate dehydrogenase isoenzyme-1: effect of time of sampling and total serum LD activityon diagnostic efficacy. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, G ReynosoClin Chem 1983; 29(3):589-590ICID: 825547Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Creatine kinase B-subunit activity in serum in cases of suspected myocardial infarction: a predictionmodel based on the slope of MB increase and percentage CK-MB activity. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, G ReynosoClin Chem 1983; 29(3):590-592ICID: 825549Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – The cytoplasmic malate dehydrogenase in neoplastic tissues; presence of a novel isoenzyme? | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| M B Grisham, L H Bernstein, J EverseBr J Cancer 1983; 47(5):727-731ICID: 825551Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Training pathologist consultants | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH BernsteinAm J Clin Pathol 1983; 79(1):270-270ICID: 844984Article type: Letter/Correspondence | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Diseconomies of scale: An analysis of hospital laboratories | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH BernsteinClin Chem 1983; 29(2):1257-1258ICID: 844985Article type: Short communication | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Reserve bilirubin binding capacity measured by absorbance deviation at saturation of primaryalbumin binding sites. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| R C Banagale, L H BernsteinRes Commun Chem Pathol Pharmacol 1982; 38(3):463-479ICID: 825600Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Preliminary use of linear discriminant function to predict success or failure of kidney transplant. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, P J Russell, W D FosterAnn Clin Lab Sci 1982; 12(1):60-67ICID: 825545Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – An evaluation of the immunochemical LD1 method in routine clinical practice. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| R Belding, LarryH Bernstein, Gustavo ReynosoClin Chem 1981; 27(10):1027-1028ICID: 844981Article type: Short communication | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Reserve albumin capacity for bilirubin measured by Sephadex absorption (SA) and by absorbancedeviation (AD) at saturation of primary albumin-binding sites | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Raul Banagale, Larry Bernstein, JJ BrayPediatric Research 1981; 15(1):476-476ICID: 844982Article type: Short communication | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Studies on the mechanism of the malate dehydrogenase reaction. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, J EverseJ Biol Chem 1978; 253(24):8702-8707ICID: 825518Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Nonparametric detection scheme for myocardial infarction | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH Bernstein, Chris Tsokos, John TurnerJ Med Syst 1978; 2(3):203-212ICID: 825655Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Substrate inhibition of the mitochondrial and cytoplasmic malate dehydrogenases. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, M B Grisham, K D Cole, J EverseJ Biol Chem 1978; 253(24):8697-8701ICID: 825513Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Automated kinetic determination of lactate dehydrogenase isoenzymes in serum. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H BernsteinClin Chem 1977; 23(10):1928-1930ICID: 825616 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Article type: Review article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Determination of the isoenzyme levels of lactate dehydrogenase. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, J EverseMethods Enzymol 1975; 41 47-52ICID: 825516Article type: Short communication | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Detection of cardiac damage using a steady state assay for lactate dehydrogenase isoenzymes inserum. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, J Everse, N Shioura, P J RussellJ Mol Cell Cardiol 1974; 6(4):297-315ICID: 825597Article type: Short communication | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Methoxyfluorane nephrotoxicity: report of a case with electron microscopic observations | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Harry Powell, R Garrett, LarryH Bernstein, R MazzeHuman Pathology 1974; 3(1):359-363ICID: 844980Article type: Case report | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Adenylate kinase in human tissue. II. Serum adenylate kinase and myocardial infarction. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| L H Bernstein, J M Horenstein, H D Sybers, P J RussellJ Mol Cell Cardiol 1973; 5(1):71-85ICID: 825590Article type: Editorial | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – Lactic dehydrogenase isoenzymes in lens and cornea | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| LarryH Bernstein, Michael Kerrigan, Harry MaiselExp Eye Res 1965; 5(3):999-1005ICID: 844979Article type: Original article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publications – Books | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Title: Clinical Chemistry: Principles, Procedures, CorrelationsEdited by: Michael L Bishop, Edward P Fody, Larry E SchoeffPublished by: 2004, Lippincott Williams & Wilkins, Philadelphia, USAISBN: 9780781746113Authorship: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – author – chapter only: Chapter Title: Geriatric Clinical Chemistry | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – author – chapter only: Chapter Title: Nutritional Assessment | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Title: Biology and Practice of Current Nutritional SupportEdited by: R Latifi, S J DudrickPublished by: 2003, LANDES BIOSCIENCE PUBLISHERS, Georgetown, USAISBN: 9781570595950Authorship: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| 2 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – author – chapter only: Chapter Title: Clinical Biochemistry of Carbohydrate, Proteins, Lipids,Vitamins and Trace Elements | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Authors: Michael G BissellTitle: Laboratory-Related Measures of Patient Outcomes: An IntroductionPublished by: 2000, American Association Clinical Chemistry, Washington, USAISBN: 9781890883263Authorship: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – author – chapter only: Chapter Title: Outcomes-based Decision Support: How to Link LaboratoryUtilization to Clinical Endpoints | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Authors: Larry H BernsteinTitle: Realization of the projected impact of a workflow management system at Bridgeport HospitalEdited by: Milton J Kowalewsky JrPublished by: 1994, American Society for Testing and Materials, Philadelphia, USAISBN: 0803118724Authorship: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – author – chapter only: Chapter Title: Realization of the Projected Impact of a Chemistry WorkflowManagement System at Bridgeport Hospital | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Authors: V Marks, K AlbertiTitle: Clinical Biochemistry Nearer the PatientPublished by: 1986, W.B. Saunders Company, London, United KingdomISBN: 9780702011801Authorship: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – author – chapter only: Chapter Title: Decentralized testing: Cost implications and benefits | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Authors: Larry H Bernstein, Johannes EverseTitle: Methods in EnzymologyEdited by: Nathan O Kaplan, Sidney P Colowick, W WoodPublished by: 1975, Academic Press, Inc, New York, USAISBN: 0121819752Authorship: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| – co-author – chapter only: Chapter Title: Determination of the isoenzyme levels of lactatedehydrogenase | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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