Breast Cancer and Mitochondrial Mutations

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Breast Cancer and Mitochondrial Mutations

March 4, 2013 by larryhbern

Breast Cancer and Mitochondrial Mutations

Author: Larry H Bernstein, MD, FCAP

Word Cloud By Danielle Smolyar

How Aggressive Breast Tumors and Mitochondrial Mutations Are Linked

Feb 18, 2013 Brunhilde H. Felding, Ph.D., Scripps Research Institute (TSRI)
Mitochondrial complex I critically determines the energy output of cellular respiration. The Felding team discovered that the balance of key metabolic cofactors processed by complex I—specifically,

nicotinamide adenine dinucleotide (NAD+) and NADH,

the form it takes after accepting a key electron in the energy production cycle—

was disturbed in aggressive breast cancer cells.

The team altered genes tied to NAD+ production. The resulting shift again showed that

higher NADH levels meant more aggressive tumors,
while increased NAD+ had the opposite effect.

The scientists found that enhancing the NAD+/NADH balance through the nicotinamide treatment inhibited metastasis, and the mice lived longer.

http://www.geneng.com/gennewsHighlights/How_Aggressive_Breast_Tumors_and_Mitochondrial_Mutations_Are_Linked/

http://www.JCl.org/Mitochondrial_Complex1_activity_and_NAD+_NADH_balance_regulate_breast_cancer_progression

Reduction and oxidation of the NAD. Created using ACD/ChemSketch 10.0 and . (Photo credit: Wikipedia)

Comparison of the absorbance spectra of NAD+ and NADH (Photo credit: Wikipedia)

English: By Richard Wheeler (Zephyris) 2006. The structure of the peripheral domain of an NADH dehydrogenase (mitochondrial complex I) related protein; bacterial FMN dehygrogenase PDB 2FUG. (Photo credit: Wikipedia)

http://pharmaceuticalintelligence.com/2012/10/31/mitochondrial-fission-and-fusion-potential-therapeutic-target/

http://pharmaceuticalintelligence.com/2013/02/03/mit-scientists-on-proteomics-all-the-proteins-in-the-mitochondrial-matrix-identified/

http://pharmaceuticalintelligence.com/2012/10/28/mitochondrial-damage-and-repair-under-oxidative-stress/

http://pharmaceuticalintelligence.com/2012/09/26/mitochondria-origin-from-oxygen-free-environment-role-in-aerobic-glycolysis-metabolic-adaptation/

http://pharmaceuticalintelligence.com/2012/09/16/nitric-oxide-has-a-ubiquitous-role-in-the-regulation-of-glycolysis-with-a-concomitant-influence-on-mitochondrial-function/

http://pharmaceuticalintelligence.com/2012/09/10/%CE%B2-integrin-emerges-as-an-important-player-in-mitochondrial-dysfunction-associated-gastric-cancer/

http://pharmaceuticalintelligence.com/2012/09/01/mitochondria-and-cancer-an-overview/

http://pharmaceuticalintelligence.com/2012/07/09/mitochondria-more-than-just-the-powerhouse-of-the-cell/

http://pharmaceuticalintelligence.com/2013/02/14/ubiquinin-proteosome-pathway-autophagy-the-mitochondrion-proteolysis-and-cell-apoptosis-reconsidered/

http://pharmaceuticalintelligence.com/2013/01/26/remembering-a-great-scientist-among-mentors/

http://pharmaceuticalintelligence.com/2013/01/26/portrait-of-a-great-scientist-and-mentor-nathan-oram-kaplan/

http://pharmaceuticalintelligence.com/2012/10/17/is-the-warburg-effect-the-cause-or-the-effect-of-cancer-a-21st-century-view/

Promising New Approach To Preventing Progression Of Breast Cancer (medicalnewstoday.com)
misshapen chemo drug particles may be better at targeting breast cancer (fiercebiotechresearch.com)
Key Enzyme Missing From Triple-Negative Breast Cancer (medicalnewstoday.com)

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Genome Biology, International Global Work in Pharmaceutical, Molecular Genetics & Pharmaceutical, Nutrigenomics, Personalized and Precision Medicine & Genomic Research, Pharmaceutical Industry Competitive Intelligence, Population Health Management, Genetics & Pharmaceutical, Population Health Management, Nutrition and Phytochemistry | Tagged breast cancer, Cancer - General, Conditions and Diseases, Energy development, health, NADH dehydrogenase, Nicotinamide adenine dinucleotide, Scripps Research Institute | 1 Comment

One Response

on March 12, 2013 at 1:33 PM | Reply AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo | Pharmaceutical Intelligence

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