Bioenergetic Mechanism: The Inverse Association of Cancer and Alzheimer’s

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Bioenergetic Mechanism: The Inverse Association of Cancer and Alzheimer’s

June 12, 2013 by 2012pharmaceutical

Reporter: Aviva Lev-Ari, PhD, RN

J R Soc Interface. 2013 Feb 20;10(82):20130006. doi: 10.1098/rsif.2013.0006. Print 2013 May 6.

The inverse association of cancer and Alzheimer’s: a bioenergetic mechanism.

Demetrius LA, Simon DK.

Source

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. ldemetr@oeb.harvard.edu

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Abstract

The sporadic forms of cancer and Alzheimer’s disease (AD) are both age-related metabolic disorders. However, the molecular mechanisms underlying the two diseases are distinct: cancer is described by essentially limitless replicative potential, whereas neuronal death is a key feature of AD. Studies of the origin of both diseases indicate that their sporadic forms are the result of metabolic dysregulation, and a compensatory increase in energy transduction that is inversely related. In cancer, the compensatory metabolic effect is the upregulation of glycolysis-the Warburg effect; in AD, a bioenergetic model based on the interaction between astrocytes and neurons indicates that the compensatory metabolic alteration is the upregulation of oxidative phosphorylation-an inverse Warburg effect. These two modes of metabolic alteration could contribute to an inverse relation between the incidence of the two diseases. We invoke this bioenergetic mechanism to furnish a molecular basis for an epidemiological observation, namely the incidence of sporadic forms of cancer and AD is inversely related. We furthermore exploit the molecular mechanisms underlying the diseases to propose common therapeutic strategies for cancer and AD based on metabolic intervention.

PMID: 23427097

PMCID: PMC3627084: [Available on 2014/5/6]; http://www.ncbi.nlm.nih.gov/pubmed/23427097?goback=%2Egde_2171620_member_248103990

Posted in Alzheimer's Disease, CANCER BIOLOGY & Innovations in Cancer Therapy, Etiology | Tagged Alzheimer, Alzheimers Disease, Cancer - General, Evolutionary Biology, Harvard University, Warburg Effect | 5 Comments

5 Responses

on June 12, 2013 at 2:58 PM | Reply larryhbern

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on June 12, 2013 at 3:01 PM | Reply larryhbern

I actually consider this amazing blog , âSAME SCIENTIFIC IMPACT: Scientific Publishing –
Open Journals vs. Subscription-based « Pharmaceutical Intelligenceâ, very compelling plus the blog post ended up being a good read.
Many thanks,Annette

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on June 12, 2013 at 3:23 PM | Reply larryhbern

I actually consider this amazing blog , âSAME SCIENTIFIC IMPACT: Scientific Publishing –
Open Journals vs. Subscription-based « Pharmaceutical Intelligenceâ, very compelling plus the blog post ended up being a good read.
Many thanks,Annette

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- on June 12, 2013 at 3:53 PM | Reply 2012pharmaceutical
  
  I actually consider this amazing blog , âSAME SCIENTIFIC IMPACT: Scientific Publishing –
  Open Journals vs. Subscription-based « Pharmaceutical Intelligenceâ, very compelling plus the blog post ended up being a good read.
  Many thanks,Annette
  
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on June 12, 2013 at 4:15 PM | Reply larryhbern

I actually consider this amazing blog , âSAME SCIENTIFIC IMPACT: Scientific Publishing –
Open Journals vs. Subscription-based « Pharmaceutical Intelligenceâ, very compelling plus the blog post ended up being a good read.
Many thanks,Annette

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