Medical Scientific Discoveries for the 21st Century & Interviews with Scientific Leaders at https://www.amazon.com/dp/B078313281 – electronic Table of Contents
Author, Curator and Editor: Larry H Bernstein, MD, FCAP
Available on Kindle Store @ Amazon.com since 12/9/2017
List of Contributors & Contributors’ Biographies
Volume Author, Curator and Editor
Larry H Bernstein, MD, FCAP
Preface, all Introductions, all Summaries and Epilogue
Part One:
1.4, 1.5, 1.6, 2.1.1, 2.1.2, 2.1.3, 2.1.4, 2.2.1, 2.2.2, 2.2.3, 2.3, 2.4, 2.4.1, 2.4.2, 2.5, 2.6.1, 2.6.2, 2.6.3, 2.6.4, 2.7, 2.8, 2.9, 2.10, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 4.3
Part Two:
5.2, 5.3, 5.6, 6.1.2, 6.1.4, 6.2.1, 6.2.2, 6.3.2, 6.3.4, 6.3.5, 6.3.6, 6.3.8, 6.3.10, 6.4.1, 6.4.2, 6.5.1.2, 6.5.1.3, 6.5.2.2, 7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8, 8.9, 8.9.1, 8.9.3, 8.9.4, 8.9.5, 8.9.6, 8.10.1, 8.10.2, 8.10.3, 8.10.4, 9.2, 9.3, 9.5, 9.6, 9.7, 9.8, 9.9, 9.10, 9.11, 9.12, 9.13, 9.14, 9.15, 9.16, 10.2, 10.5, 10.6, 10.7, 10.8, 10.10, 10.11, 11.1, 11.2, 11.3, 11.5, 11.6, 11.7, 12.1, 12.2, 12.3, 12.4, 12.5, 12.7, 12.8, 12.9, 12.10, 12.11, 12.12, 13.1, 13.2, 13.3, 13.6, 13.12, 13.13, 14.1, 14.2
Guest Authors:
Pnina Abir-Am, PhD Part Two: 6.1.1
Stephen J Williams, PhD: Part Two: 6.2.6, 6.5.2.2, 10.4, 10.9, 13.4
Aviva Lev-Ari, PhD, RN:
Part One:
1.1, 1.2, 1.3, 1.4, 1.5, 1.7, 2.2.1, 2.3
Part Two:
5.1, 5.4, 5.5, 5.7, 5.8, 5.9, 5.10, 5.11, 6.1.3, 6.2.3, 6.2.4, 6.2.5, 6.3.1, 6.3.3, 6.3.7, 6.3.9, 6.4.3, 6.5.1.1, 6.5.2.1, 6.5.2.2, 6.5.3.1, 6.5.4, 6.5.5, 6,5,6, 8.9.2, 8.10.2, 9.1, 9.4, 10.1, 10.3, 11.4, 12.6, 13.5, 13.7, 13.8, 13.9, 13.10, 13.11
Adam Sonnenberg, BSC, MSc(c): Part Two: 13.9
electronic Table of Contents
PART ONE:
Physician as Authors, Writers in Medicine and Educator in Public Health
Chapter 1: Physicians as Authors
Introduction
1.1 The Young Surgeon and The Retired Pathologist: On Science, Medicine and HealthCare Policy – Best writers Among the WRITERS
1.2 Atul Gawande: Physician and Writer
1.3 Editorial & Publication of Articles in e-Books by Leaders in Pharmaceutical Business Intelligence: Contributions of Larry H Bernstein, MD, FCAP
1.4 Abraham Verghese, MD, Physician and Notable Author
1.5 Eric Topol, M.D.
1.6 Gregory House, MD
1.7 Peter Mueller, MD Professor of Radiology @MGH & HMS – 2015 Synergy’s Honorary Award Recipient
Summary
Chapter 2: Professional Recognition
Introduction
2.1 Proceedings
2.1.1 Research Presentations
2.1.2 Proceedings of the NYAS
2.1.3 Cold Spring Harbor Conference Meetings
2.1.4 Young Scientist Seminars
2.2 Meet Great Minds
2.2.1 Meet the Laureates
2.2.2 Richard Feynman, Genius and Laureate
2.2.3 Fractals and Heat Energy
2.3 MacArthur Foundation Awards
2.4 Women’s Contributions went beyond Rosie the Riveter
2.4.1 Secret Maoist Chinese Operation Conquered Malaria
2.4.2 Antiparasite Drug Developers Win Nobel
2.5 Impact Factors and Achievement
2.6 RAPsodisiac Medicine
2.6.1 Outstanding-achievements-in-radiology-or-radiotherapy
2.6.2 Outstanding-achievement-in-anesthesiology
2.6.3 Outstanding-achievement-in-pathology
2.6.4 Topics in Pathology – Special Issues from Medscape Pathology
2.7 How to win the Nobel Prize
2.8 Conversations about Medicine
2.9 Current Advances in Medical Technology
2.10 Atul Butte, MD, PhD
Summary
Chapter 3: Medical and Allied Health Sciences Education
Introduction
3.1 National Outstanding Medical Student Award Winners
3.2 Outstanding Awards in Medical Education
3.3 Promoting Excellence in Physicians and Nurses
3.4 Excellence in mentoring
Summary
Chapter 4: Science Teaching in Math and Technology (STEM)
Introduction
4.1 Science Teaching in Math and Technology
4.2 Television as a Medium for Science Education
4.2.1 Science Discovery TV
4.3 From Turing to Watson
Summary
PART TWO:
Medical Scientific Discoveries & Interviews with Scientific Leaders
Chapter 5: Cardiovascular System
Introduction
5.1 Physiologist, Professor Lichtstein, Chair in Heart Studies at The Hebrew University elected Dean of the Faculty of Medicine at The Hebrew University of Jerusalem
5.2 Mitochondrial Dysfunction and Cardiac Disorders
5.3 Notable Contributions to Regenerative Cardiology
5.4 For Accomplishments in Cardiology and Cardiovascular Diseases: The Arrigo Recordati International Prize for Scientific Research
5.5 Becoming a Cardiothoracic Surgeon: An Emerging Profile in the Surgery Theater and through Scientific Publications
5.6 Diagnostics and Biomarkers: Novel Genomics Industry Trends vs Present Market Conditions and Historical Scientific Leaders Memoirs
5.7 CVD Prevention and Evaluation of Cardiovascular Imaging Modalities: Coronary Calcium Score by CT Scan Screening to justify or not the Use of Statin
5.8 2013 as A Year of Revolutionizing Medicine and Top 11 Cardiology Stories
5.9 Bridging the Gap in Medical Innovations – Elazer Edelman @ TEDMED 2013
5.10 Development of a Pancreatobiliary Chemotherapy Eluting Stent for Pancreatic Ductal Adenocarcinoma PIs: Jeffrey Clark (MGH), Robert Langer (Koch), Elazer Edelman (Harvard:MIT HST Program)
5.11 Publications on Heart Failure by Prof. William Gregory Stevenson, M.D., BWH
Summary
Chapter 6: Genomics
Introduction
6.1 Genetics before the Human Genome Project
6.1.1 Why did Pauling Lose the “Race” to James Watson and Francis Crick? How Crick Describes his Discovery in a Letter to his Son
6.1.2 John Randall’s MRC Research Unit and Rosalind Franklin’s role at Kings College
6.1.3 Interview with the co-discoverer of the structure of DNA: Watson on The Double Helix and his changing view of Rosalind Franklin
6.1.4 The Initiation and Growth of Molecular Biology and Genomics, Part I
6.2 The Human Genome Project: Articles of Note @ pharmaceuticalintelligence.com by multiple authors
6.2.1 CRACKING THE CODE OF HUMAN LIFE: The Birth of BioInformatics & Computational Genomics
6.2.2 What comes after finishing the Euchromatic Sequence of the Human Genome?
6.2.3 Human Genome Project – 10th Anniversary: Interview with Kevin Davies, PhD – The $1000 Genome
6.2.4 University of California Santa Cruz’s Genomics Institute will create a Map of Human Genetic Variations
6.2.5 Exceptional Genomes: The Process to find them
6.2.6 Multiple Lung Cancer Genomic Projects Suggest New Targets, Research Directions for Non-Small Cell Lung Cancer
6.3 The Impact of Genome Sequencing on Biology and Medicine
6.3.1 Genomics in Medicine – Establishing a Patient-Centric View of Genomic Data
6.3.2 Modification of genes by homologous recombination – Mario Capecchi, Martin Evans, Oliver Smithies
6.3.3 AAAS February 14-18, 2013, Boston: Symposia – The Science of Uncertainty in Genomic Medicine
6.3.4 The Metabolic View of Epigenetic Expression
6.3.5 Pharmacogenomics
6.3.6 Neonatal Pathophysiology
6.3.7 Genetics of Conduction Disease: Atrioventricular (AV) Conduction Disease (block): Gene Mutations – Transcription, Excitability, and Energy Homeostasis
6.3.8 3D mapping of genome in combine FISH and RNAi
6.3.9 Human Variome Project: encyclopedic catalog of sequence variants indexed to the human genome sequence
6.3.10 DNA mutagenesis and DNA repair
6.4 Scientific Leadership Recognition for Contributions to Genomics
6.4.1 Interview with Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak (44 minutes)
6.4.2 DNA Repair Pioneers Win Nobel – Tomas Lindahl, Paul Modrich, and Aziz Sancar 2015 Nobel Prize in Chemistry for the mechanisms of DNA repair
6.4.3 Richard Lifton, MD, PhD of Yale University and Howard Hughes Medical Institute: Recipient of 2014 Breakthrough Prizes Awarded in Life Sciences for the Discovery of Genes and Biochemical Mechanisms that cause Hypertension
6.5 Contemporary Field Leaders in Genomics
6.5.1 ROBERT LANGER
6.5.1.1 2014 Breakthrough Prizes Awarded in Fundamental Physics and Life Sciences for a Total of $21 Million – MIT’s Robert Langer gets $3 Million
6.5.1.2 National Medal of Science – 2006 Robert S. Langer
6.5.1.3 Confluence of Chemistry, Physics, and Biology
6.5.2 JENNIFER DOUDNA
6.5.2.1 Jennifer Doudna, cosmology teams named 2015 Breakthrough Prize winners
6.5.2.2 UPDATED – Medical Interpretation of the Genomics Frontier – CRISPR – Cas9: Gene Editing Technology for New Therapeutics
6.5.3 ERIC LANDER
6.5.3.1 2012 Harvey Prize in April 30: at the Technion-Israel Institute of Technology to Eric S. Lander @MIT & Eli Yablonovitch @UC, Berkeley
6.5.4 2013 Genomics: The Era Beyond the Sequencing of the Human Genome: Francis Collins, Craig Venter, Eric Lander, et al.
6.5.5 Recognitions for Contributions in Genomics by Dan David Prize Awards
6.5.6 65 Nobel Laureates meet 650 young scientists covering the fields of physiology and medicine, physics, and chemistry, 28 June – 3 July, 2015, Lindau & Mainau Island, Germany
Summary
Chapter 7: The RNAs
Introduction
7.1 RNA polymerase – molecular basis for DNA transcription – Roger Kornberg, MD
7.2 One gene, one protein – Charles Yanofsky
7.3 Turning genetic information into working proteins – James E. Darnell Jr.
7.4 Small but mighty RNAs – Victor Ambros, David Baulcombe, and Gary Ruvkun, Phillip A. Sharp
7.5 Stress-response gene networks – Nina V. Fedoroff
Summary
Chapter 8: Proteomics, Protein-folding, and Cell Regulation
Introduction.
8.1 The Life and Work of Allan Wilson
8.2 Proteomics
8.3 More Complexity in Protein Evolution
8.4 Proteins: An evolutionary record of diversity and adaptation
8.5 Heroes in Basic Medical Research – Leroy Hood
8.6 Ubiquitin researchers win Nobel – Ciechanover, Hershko, and Rose awarded for discovery of ubiquitin-mediated proteolysis
8.7 Buffering of genetic modules involved in tricarboxylic acid cycle metabolism provides homeostatic regulation
8.8 Dynamic Protein Profiling
8.9 Protein folding
8.9.1 Protein misfolding and prions – Susan L. Lindquist, Stanley B. Prusiner
8.9.2 A Curated Census of Autophagy-Modulating Proteins and Small Molecules Candidate Targets for Cancer Therapy
8.9.3 Voluntary and Involuntary S-Insufficiency
8.9.4 Transthyretin and Lean Body Mass in Stable and Stressed State
8.9.5 The matter of stunting in the Ganges Plains
8.9.6 Proteins, Imaging and Therapeutics
8.10 Protein Folding and Vesicle Cargo
8.10.1 Heat Shock Proteins (HSP) and Molecular Chaperones
8.10.2 Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and sub epithelial myofibroblasts
8.10.3 Biology, Physiology and Pathophysiology of Heat Shock Proteins
8.10.4 The Role of Exosomes in Metabolic Regulation
Summary
Chapter 9: Neuroscience
Introduction
9.1 Nobel Prize in Physiology or Medicine 2013 for Cell Transport: James E. Rothman of Yale University; Randy W. Schekman of the University of California, Berkeley; and Dr. Thomas C. Südhof of Stanford University
9.2 Proteins that control neurotransmitter release – Richard H. Scheller
9.3 Heroes in Basic Medical Research – Robert J. Lefkowitz
9.4 MIND AND MEMORY: BIOLOGICAL AND DIGITAL – 2014 Dan David Prize Symposium
9.5 A new way of moving – Michael Sheetz, James Spudich, Ronald Vale
9.6 Role the basal ganglia
9.7 The Neurogenetics of Language – Patricia Kuhl – 2015 George A. Miller Award
9.8 The structure of our visual system
9.9 Outstanding Achievement in Schizophrenia Research
9.10 George A. Miller, a Pioneer in Cognitive Psychology, Is Dead at 92
9.11 – To understand what happens in the brain to cause mental illness
9.12 Brain and Cognition
9.13 – To reduce symptoms of mental illness and retrain the brain
9.14 Behavior
9.15 Notable Papers in Neurosciences
9.16 Pyrroloquinoline quinone (PQQ) – an unproved supplement
Summary
Chapter 10: Microbiology & Immunology
Introduction
10.1 Reference Genes in the Human Gut Microbiome: The BGI Catalogue
10.2 Malnutrition in India, high newborn death rate and stunting of children age under five years
10.3 In His Own Words: Leonard Herzenberg, The Immunologist Who Revolutionized Research, Dies at 81
10.4 Heroes in Medical Research: Dr. Robert Ting, Ph.D. and Retrovirus in AIDS and Cancer
10.5 Tang Prize for 2014: Immunity and Cancer
10.6 Halstedian model of cancer progression
10.7 The History of Hematology and Related Sciences
10.8 Pathology Emergence in the 21st Century
10.9 Heroes in Medical Research: Barnett Rosenberg and the Discovery of Cisplatin
10.10 T cell-mediated immune responses & signaling pathways activated by TLRs – Bruce A. Beutler, Jules A. Hoffmann, Ralph M. Steinman
10.11 Roeder – the coactivator OCA-B, the first cell-specific coactivator, discovered by Roeder in 1992, is unique to immune system B cells
Summary
Chapter 11: Endocrine Hormones
Introduction
11.1 Obesity – 2010 Douglas L. Coleman, Jeffrey M. Friedman
11.2 Lonely Receptors: RXR – Jensen, Chambon, and Evans – Nuclear receptors provoke RNA production in response to steroid hormones
11.3 The Fred Conrad Koch Lifetime Achievement Award—the Society’s highest honor—recognizes the lifetime achievements and exceptional contributions of an individual to the field of endocrinology
11.4 Gerald D Aurbach Award for Outstanding Translational Research
11.5 Roy O. Greep Award for Outstanding Research in Endocrinology – Martin M. Matzuk
11.6 American Physiology Society Awards
11.7 Solomon Berson and Rosalyn Yalow
Summary
Chapter 12. Stem Cells
Introduction
12.1 Mature cells can be reprogrammed to become pluripotent – John Gurdon and Shinya Yamanaka
12.2 Observing the spleen colonies in mice and proving the existence of stem cells – Till and McCulloch
12.3 McEwen Award for Innovation: Irving Weissman, M.D., Stanford School of Medicine, and Hans Clevers, M.D., Ph.D., Hubrecht Institute
12.4 Developmental biology
12.5 CRISPR/Cas-mediated genome engineering – Rudolf Jaenisch
12.6 Ribozymes and RNA Machines – Work of Jennifer A. Doudna
12.7 Ralph Brinster, ‘Father of Transgenesis’
12.8 Targeted gene modification
12.9 Stem Cells and Cancer
12.10 ALPSP Awards
12.11 Eppendorf Award for Young European Investigators
12.12 Breaking news about genomic engineering, T2DM and cancer treatments
Summary
Chapter 13: 3D Printing and Medical Application
Introduction
13.1 3D Printing
13.2 What is 3D printing?
13.3 The Scientist Who Is Making 3D Printing More Human
13.4 Join These Medical 3D Printing Groups on Twitter and LinkedIn for great up to date news
13.5 Neri Oxman and her Mediated Matter group @MIT Media Lab have developed a technique for 3D-printing Molten Glass
13.6 The ‘chemputer’ that could print out any drug
13.7 3-D-Bioprinting in use to Create Cardiac Living Tissue: Print your Heart out
13.8 LPBI’s Perspective on Medical and Life Sciences Applications – 3D Printing: BioInks, BioMaterials-BioPolymer
13.9 Medical MEMS, Sensors and 3D Printing: Frontier in Process Control of BioMaterials
13.10 NIH and FDA on 3D Printing in Medical Applications: Views for On-demand Drug Printing, in-Situ direct Tissue Repair and Printed Organs for Live Implants
13.11 ‘Pop-up’ fabrication technique trumps 3D printing
13.12 Augmentation of the ONTOLOGY of the 3D Printing Research
13.13 Superresolution Microscopy
Summary
Chapter 14: Synthetic Medicinal Chemistry
Introduction
14.1 Insights in Biological and Synthetic Medicinal Chemistry
14.2 Breakthrough work in cancer
Summary to Part Two
Volume Summary and Conclusions
EPILOGUE
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