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Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

January 25, 2016 by 2012pharmaceutical

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

Biochem Biophys Res Commun. 2015 Jan 16;456(3):707-13. doi: 10.1016/j.bbrc.2014.12.051. Epub 2014 Dec 16.

De novo design based pharmacophore query generation and virtual screening for the discovery of Hsp-47 inhibitors.

Katarkar A¹, Haldar PK², Chaudhuri K³.

Author information

Abstract

Heat shock protein-47 (Hsp-47) is exclusive collagen specific molecular chaperone involved in the maturation, processing and secretion of procollagen. Hsp-47 is consistently upregulated in several fibrotic diseases. Till date there is no potential antifibrotic small molecule drug available and Hsp-47 is known to be potential therapeutic target for fibrotic disorder and drug designing. We used the de novo drug design approach followed by pharmacophore generation and virtual screening to propose Hsp-47 based antifibrotic molecules. We used e-LEAD server for de novo drug design and ZINCPharmer for 3D pharmacophore generation and virtual screening. The virtually screened molecule may inhibit direct recruitment of collagen triple helix to interact with Hsp-47 and act as antifibrotic drug.

KEYWORDS:

De novo drug designing; Heat shock protein 47; Pharmacophore; Virtual screening

PMID:: 25522881; [PubMed – indexed for MEDLINE]

SOURCE

http://www.ncbi.nlm.nih.gov/pubmed/25522881

REFERENCES

1.	Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn’s disease.
	Honzawa Y, Nakase H, Shiokawa M, Yoshino T, Imaeda H, Matsuura M, Kodama Y, Ikeuchi H, Andoh A, Sakai Y, Nagata K, Chiba T.
	Gut. 2014 Dec;63(12):1902-12. doi: 10.1136/gutjnl-2013-305632. Epub 2014 Feb 17.
	PMID: 24534724 [PubMed – indexed for MEDLINE]
	Similar articles

2.	Role of heat shock protein 47 in intestinal fibrosis of experimental colitis.
	Kitamura H, Yamamoto S, Nakase H, Matsuura M, Honzawa Y, Matsumura K, Takeda Y, Uza N, Nagata K, Chiba T.
	Biochem Biophys Res Commun. 2011 Jan 14;404(2):599-604. doi: 10.1016/j.bbrc.2010.12.006. Epub 2010 Dec 6.
	PMID: 21144841 [PubMed – indexed for MEDLINE]
	Similar articles

3.	Interstitial expression of heat shock protein 47 and alpha-smooth muscle actin in renal allograft failure.
	Abe K, Ozono Y, Miyazaki M, Koji T, Shioshita K, Furusu A, Tsukasaki S, Matsuya F, Hosokawa N, Harada T, Taguchi T, Nagata K, Kohno S.
	Nephrol Dial Transplant. 2000 Apr;15(4):529-35.
	PMID: 10727549 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

4.	Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats.
	Nishino T, Miyazaki M, Abe K, Furusu A, Mishima Y, Harada T, Ozono Y, Koji T, Kohno S.
	Kidney Int. 2003 Sep;64(3):887-96.
	PMID: 12911538 [PubMed – indexed for MEDLINE]
	Similar articles

5.	Involvement of heat shock protein 47 in Schistosoma japonicum-induced hepatic fibrosis in mice.
	Huang JQ, Tao R, Li L, Ma K, Xu L, Ai G, Fan XX, Jiao YT, Ning Q.
	Int J Parasitol. 2014 Jan;44(1):23-35. doi: 10.1016/j.ijpara.2013.08.009. Epub 2013 Dec 1.
	PMID: 24295791 [PubMed – indexed for MEDLINE]
	Similar articles

6.	The collagen-specific molecular chaperone HSP47: is there a role in fibrosis?
	Taguchi T, Razzaque MS.
	Trends Mol Med. 2007 Feb;13(2):45-53. Epub 2006 Dec 13.
	PMID: 17169614 [PubMed – indexed for MEDLINE]
	Similar articles

7.	Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement.
	Truchetet ME, Brembilla NC, Montanari E, Lonati P, Raschi E, Zeni S, Fontao L, Meroni PL, Chizzolini C.
	Arthritis Rheum. 2013 May;65(5):1347-56. doi: 10.1002/art.37860.
	PMID: 23335253 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

8.	[Effect of heat shock protein 47 on the expression of collagen I induced by TGF-beta(1) in hepatic stellate cell-T6 cells].
	Li Y, Wu W, Jiang YF, Wang KK.
	Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Aug;32(4):650-5. Chinese.
	PMID: 17767059 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

23.	Tumor budding, myofibroblast proliferation, and fibrosis in obstructing colon carcinoma: the roles of Hsp47 and basic fibroblast growth factor.
	Xu CJ, Mikami T, Nakamura T, Tsuruta T, Nakada N, Yanagisawa N, Jiang SX, Okayasu I.
	Pathol Res Pract. 2013 Feb 15;209(2):69-74. doi: 10.1016/j.prp.2012.10.008. Epub 2012 Dec 21.
	PMID: 23265436 [PubMed – indexed for MEDLINE]
	Similar articles

24.	The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease.
	Sugihara T, Kobori A, Imaeda H, Tsujikawa T, Amagase K, Takeuchi K, Fujiyama Y, Andoh A.
	Clin Exp Immunol. 2010 Jun;160(3):386-93. doi: 10.1111/j.1365-2249.2010.04093.x. Epub 2010 Jan 19.
	PMID: 20089077 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

25.	Effect of heat shock protein 47 on collagen accumulation in keloid fibroblast cells.
	Chen JJ, Zhao S, Cen Y, Liu XX, Yu R, Wu DM.
	Br J Dermatol. 2007 Jun;156(6):1188-95.
	PMID: 17535221 [PubMed – indexed for MEDLINE]
	Similar articles

26.	Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn’s disease and analysis of the IL17F p.His161Arg polymorphism in IBD.
	Seiderer J, Elben I, Diegelmann J, Glas J, Stallhofer J, Tillack C, Pfennig S, Jürgens M, Schmechel S, Konrad A, Göke B, Ochsenkühn T, Müller-Myhsok B, Lohse P, Brand S.
	Inflamm Bowel Dis. 2008 Apr;14(4):437-45.
	PMID: 18088064 [PubMed – indexed for MEDLINE]
	Similar articles

27.	Induction of heat shock protein 47 synthesis by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1.
	Sasaki H, Sato T, Yamauchi N, Okamoto T, Kobayashi D, Iyama S, Kato J, Matsunaga T, Takimoto R, Takayama T, Kogawa K, Watanabe N, Niitsu Y.
	J Immunol. 2002 May 15;168(10):5178-83.
	PMID: 11994473 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

28.	Increased activation of latent TGF-β1 by αVβ3 in human Crohn’s disease and fibrosis in TNBS colitis can be prevented by cilengitide.
	Li C, Flynn RS, Grider JR, Murthy KS, Kellum JM, Akbari H, Kuemmerle JF.
	Inflamm Bowel Dis. 2013 Dec;19(13):2829-39. doi: 10.1097/MIB.0b013e3182a8452e.
	PMID: 24051933 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

29.	Distinct profiles of effector cytokines mark the different phases of Crohn’s disease.
	Zorzi F, Monteleone I, Sarra M, Calabrese E, Marafini I, Cretella M, Sedda S, Biancone L, Pallone F, Monteleone G.
	PLoS One. 2013;8(1):e54562. doi: 10.1371/journal.pone.0054562. Epub 2013 Jan 17.
	PMID: 23349929 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

30.	CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts.
	Johnson LA, Sauder KL, Rodansky ES, Simpson RU, Higgins PD.
	Exp Mol Pathol. 2012 Aug;93(1):91-8. doi: 10.1016/j.yexmp.2012.04.014. Epub 2012 Apr 18.
	PMID: 22542712 [PubMed – indexed for MEDLINE]
	Similar articles

31.	TAK1 is a key modulator of the profibrogenic phenotype of human ileal myofibroblasts in Crohn’s disease.
	Grillo AR, Scarpa M, D’Incà R, Brun P, Scarpa M, Porzionato A, De Caro R, Martines D, Buda A, Angriman I, Palù G, Sturniolo GC, Castagliuolo I.
	Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G443-54. doi: 10.1152/ajpgi.00400.2014. Epub 2015 Jul 16.
	PMID: 26185333 [PubMed – indexed for MEDLINE]
	Similar articles

32.	IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation.
	Tan Z, Qian X, Jiang R, Liu Q, Wang Y, Chen C, Wang X, Ryffel B, Sun B.
	J Immunol. 2013 Aug 15;191(4):1835-44. doi: 10.4049/jimmunol.1203013. Epub 2013 Jul 10.
	PMID: 23842754 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

33.	Epithelial expression of interleukin-37b in inflammatory bowel disease.
	Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Ban H, Bamba S, Sonoda H, Shimizu T, Fujiyama Y, Andoh A.
	Clin Exp Immunol. 2013 Jun;172(3):410-6. doi: 10.1111/cei.12061.
	PMID: 23600829 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

34.	Matrix stiffness corresponding to strictured bowel induces a fibrogenic response in human colonic fibroblasts.
	Johnson LA, Rodansky ES, Sauder KL, Horowitz JC, Mih JD, Tschumperlin DJ, Higgins PD.
	Inflamm Bowel Dis. 2013 Apr;19(5):891-903. doi: 10.1097/MIB.0b013e3182813297.
	PMID: 23502354 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

35.	Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis.
	Ishida Y, Kubota H, Yamamoto A, Kitamura A, Bächinger HP, Nagata K.
	Mol Biol Cell. 2006 May;17(5):2346-55. Epub 2006 Mar 8.
	PMID: 16525016 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

36.	IL-10 treatment is associated with prohibitin expression in the Crohn’s disease intestinal fibrosis mouse model.
	Yuan C, Chen WX, Zhu JS, Chen NW, Lu YM, Ou YX, Chen HQ.
	Mediators Inflamm. 2013;2013:617145. doi: 10.1155/2013/617145. Epub 2013 Apr 14.
	PMID: 23690666 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

37.	Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts.
	Sponheim J, Pollheimer J, Olsen T, Balogh J, Hammarström C, Loos T, Kasprzycka M, Sørensen DR, Nilsen HR, Küchler AM, Vatn MH, Haraldsen G.
	Am J Pathol. 2010 Dec;177(6):2804-15. doi: 10.2353/ajpath.2010.100378. Epub 2010 Oct 29.
	PMID: 21037074 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

38.	The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts.
	Oguro A, Sakurai T, Fujita Y, Lee S, Kubota H, Nagata K, Atomi Y.
	Genes Cells. 2006 Nov;11(11):1253-65.
	PMID: 17054723 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

39.	HSP47 siRNA conjugated with cationized gelatin microspheres suppresses peritoneal fibrosis in mice.
	Obata Y, Nishino T, Kushibiki T, Tomoshige R, Xia Z, Miyazaki M, Abe K, Koji T, Tabata Y, Kohno S.
	Acta Biomater. 2012 Jul;8(7):2688-96. doi: 10.1016/j.actbio.2012.03.050. Epub 2012 Apr 6.
	PMID: 22487929 [PubMed – indexed for MEDLINE]
	Similar articles

40.	Antisense oligonucleotide inhibition of heat shock protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats.
	Hagiwara S, Iwasaka H, Matsumoto S, Noguchi T.
	Respir Res. 2007 May 15;8:37.
	PMID: 17504519 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

41.	Interleukin-17A plays a pivotal role in cholestatic liver fibrosis in mice.
	Hara M, Kono H, Furuya S, Hirayama K, Tsuchiya M, Fujii H.
	J Surg Res. 2013 Aug;183(2):574-82. doi: 10.1016/j.jss.2013.03.025. Epub 2013 Mar 28.
	PMID: 23578751 [PubMed – indexed for MEDLINE]
	Similar articles

42.	Involvement of interleukin-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut motor dysfunction.
	Akiho H, Tokita Y, Nakamura K, Satoh K, Nishiyama M, Tsuchiya N, Tsuchiya K, Ohbuchi K, Iwakura Y, Ihara E, Takayanagi R, Yamamoto M.
	PLoS One. 2014 May 5;9(5):e92960. doi: 10.1371/journal.pone.0092960. eCollection 2014.
	PMID: 24796324 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

43.	Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2.
	Theiss AL, Simmons JG, Jobin C, Lund PK.
	J Biol Chem. 2005 Oct 28;280(43):36099-109. Epub 2005 Sep 1.
	PMID: 16141211 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

44.	Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress collagen accumulation in experimental glomerulonephritis.
	Sunamoto M, Kuze K, Tsuji H, Ohishi N, Yagi K, Nagata K, Kita T, Doi T.
	Lab Invest. 1998 Aug;78(8):967-72.
	PMID: 9714184 [PubMed – indexed for MEDLINE]
	Similar articles

45.	Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn’s disease.
	Burke JP, Ferrante M, Dejaegher K, Watson RW, Docherty NG, De Hertogh G, Vermeire S, Rutgeerts P, D’Hoore A, Penninckx F, Geboes K, Van Assche G, O’Connell PR.
	Inflamm Bowel Dis. 2008 Sep;14(9):1197-204. doi: 10.1002/ibd.20482.
	PMID: 18452219 [PubMed – indexed for MEDLINE]
	Similar articles

46.	The change of HSP47, collagen specific molecular chaperone, expression in rat skeletal muscle may regulate collagen production with gravitational conditions.
	Oguro A, Sakurai T, Okuno M, Nagata K, Atomi Y.
	Biol Sci Space. 2004 Nov;18(3):150-1.
	PMID: 15858365 [PubMed – indexed for MEDLINE]
	Similar articles

47.	IL-23/IL-17A axis correlates with the nitric oxide pathway in inflammatory bowel disease: immunomodulatory effect of retinoic acid.
	Rafa H, Saoula H, Belkhelfa M, Medjeber O, Soufli I, Toumi R, de Launoit Y, Moralès O, Nakmouche M, Delhem N, Touil-Boukoffa C.
	J Interferon Cytokine Res. 2013 Jul;33(7):355-68. doi: 10.1089/jir.2012.0063. Epub 2013 Mar 8.
	PMID: 23472658 [PubMed – indexed for MEDLINE]
	Similar articles

48.	[Therapeutic strategy for fibrotic diseases by regulating the expression of collagen-specific molecular chaperone HSP47].
	Nagata K.
	Nihon Yakurigaku Zasshi. 2003 Jan;121(1):4-14. Review. Japanese.
	PMID: 12617032 [PubMed – indexed for MEDLINE]
	Similar articles

49.	Functional linkage between the endoplasmic reticulum protein Hsp47 and procollagen expression in human vascular smooth muscle cells.
	Rocnik EF, van der Veer E, Cao H, Hegele RA, Pickering JG.
	J Biol Chem. 2002 Oct 11;277(41):38571-8. Epub 2002 Aug 5.
	PMID: 12163502 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

50.	Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn’s disease.
	Ogino T, Nishimura J, Barman S, Kayama H, Uematsu S, Okuzaki D, Osawa H, Haraguchi N, Uemura M, Hata T, Takemasa I, Mizushima T, Yamamoto H, Takeda K, Doki Y, Mori M.
	Gastroenterology. 2013 Dec;145(6):1380-91.e1. doi: 10.1053/j.gastro.2013.08.049. Epub 2013 Aug 29.
	PMID: 23993972 [PubMed – indexed for MEDLINE]
	Similar articles

51.	The possible role of colligin/HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases.
	Razzaque MS, Taguchi T.
	Histol Histopathol. 1999 Oct;14(4):1199-212. Review.
	PMID: 10506936 [PubMed – indexed for MEDLINE]
	Similar articles

52.	Heat shock protein 47 is expressed in fibrous regions of human atheroma and Is regulated by growth factors and oxidized low-density lipoprotein.
	Rocnik E, Chow LH, Pickering JG.
	Circulation. 2000 Mar 21;101(11):1229-33.
	PMID: 10725279 [PubMed – indexed for MEDLINE] Free Article
	Similar articles

53.	Can we influence fibrosis in Crohn’s disease?
	Assche GV.
	Acta Gastroenterol Belg. 2001 Apr-Jun;64(2):193-6.
	PMID: 11475134 [PubMed – indexed for MEDLINE]
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54.	Role of MutS homolog 2 (MSH2) in intestinal myofibroblast proliferation during Crohn’s disease stricture formation.
	Floer M, Binion DG, Nelson VM, Manley S, Wellner M, Sadeghi S, Behmaram B, Sewell C, Otterson MF, Kucharzik T, Rafiee P.
	Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G581-90. doi: 10.1152/ajpgi.90311.2008. Epub 2008 Jul 17.
	PMID: 18635600 [PubMed – indexed for MEDLINE] Free PMC Article
	Similar articles

55.	Prostaglandin E₂ and polyenylphosphatidylcholine protect against intestinal fibrosis and regulate myofibroblast function.
	Baird AC, Lloyd F, Lawrance IC.
	Dig Dis Sci. 2015 Jun;60(6):1603-16. doi: 10.1007/s10620-015-3552-9. Epub 2015 Jan 29.
	PMID: 25630423 [PubMed – indexed for MEDLINE]
	Similar articles

56.	Contribution of intestinal smooth muscle to Crohn’s disease fibrogenesis.
	Severi C, Sferra R, Scirocco A, Vetuschi A, Pallotta N, Pronio A, Caronna R, Di Rocco G, Gaudio E, Corazziari E, Onori P.
	Eur J Histochem. 2014 Dec 17;58(4):2457. doi: 10.4081/ejh.2014.2457.
	PMID: 25578979 [PubMed – indexed for MEDLINE] Free PMC Article
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57.	Interleukin-17A contributes to the development of post-operative atrial fibrillation by regulating inflammation and fibrosis in rats with sterile pericarditis.
	Fu XX, Zhao N, Dong Q, Du LL, Chen XJ, Wu QF, Cheng X, Du YM, Liao YH.
	Int J Mol Med. 2015 Jul;36(1):83-92. doi: 10.3892/ijmm.2015.2204. Epub 2015 May 8.
	PMID: 25955429 [PubMed – in process] Free PMC Article
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58.	Hallmarks of epithelial to mesenchymal transition are detectable in Crohn’s disease associated intestinal fibrosis.
	Scharl M, Huber N, Lang S, Fürst A, Jehle E, Rogler G.
	Clin Transl Med. 2015 Feb 7;4:1. doi: 10.1186/s40169-015-0046-5. eCollection 2015.
	PMID: 25852817 [PubMed] Free PMC Article
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59.	Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn’s disease.
	Zorzi F, Calabrese E, Monteleone G.
	Clin Sci (Lond). 2015 Dec;129(12):1107-13. doi: 10.1042/CS20150472. Review.
	PMID: 26494636 [PubMed – indexed for MEDLINE]
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60.	Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis.
	Morry J, Ngamcherdtrakul W, Gu S, Goodyear SM, Castro DJ, Reda MM, Sangvanich T, Yantasee W.
	Biomaterials. 2015 Oct;66:41-52. doi: 10.1016/j.biomaterials.2015.07.005. Epub 2015 Jul 10.
	PMID: 26196532 [PubMed – in process]
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61.	Mechanisms that mediate the development of fibrosis in patients with Crohn’s disease.
	Li C, Kuemmerle JF.
	Inflamm Bowel Dis. 2014 Jul;20(7):1250-8. doi: 10.1097/MIB.0000000000000043. Review.
	PMID: 24831560 [PubMed – indexed for MEDLINE] Free PMC Article
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	Borrelli M, Gianfrani C, Lania G, Aitoro R, Ferrara K, Nanayakkara M, Ponticelli D, Zanzi D, Discepolo V, Vitale S, Barone MV, Troncone R, Auricchio R, Maglio M.
	Am J Gastroenterol. 2016 Jan;111(1):134-44. doi: 10.1038/ajg.2015.390. Epub 2016 Jan 12.
	PMID: 26753888 [PubMed – in process]
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	Pillai JP, Parmar GJ, Rawal R, Shaikh F, Chauhan GR, Pillai RJ.
	Indian J Dent Res. 2014 Sep-Oct;25(5):580-5. doi: 10.4103/0970-9290.147094.
	PMID: 25511055 [PubMed – in process] Free Article
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64.

De novo design based pharmacophore query generation and virtual screening for the discovery of Hsp-47 inhibitors.

Katarkar A, Haldar PK, Chaudhuri K.

Biochem Biophys Res Commun. 2015 Jan 16;456(3):707-13. doi: 10.1016/j.bbrc.2014.12.051. Epub 2014 Dec 16.

PMID: 25522881 [PubMed – indexed for MEDLINE]

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Funding, Deals & Partnerships: BIOLOGICS & MEDICAL DEVICES; BioMed e-Series; Medicine and Life Sciences Scientific Journal – http://PharmaceuticalIntelligence.com

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

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Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Funding, Deals & Partnerships: BIOLOGICS & MEDICAL DEVICES; BioMed e-Series; Medicine and Life Sciences Scientific Journal – http://PharmaceuticalIntelligence.com

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

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Abstract

KEYWORDS:

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