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Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

Posted in Autoimmune Inflammatory DIseases, tagged Proinflammatory cytokines on January 25, 2016| Leave a Comment »

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

Biochem Biophys Res Commun. 2015 Jan 16;456(3):707-13. doi: 10.1016/j.bbrc.2014.12.051. Epub 2014 Dec 16.

De novo design based pharmacophore query generation and virtual screening for the discovery of Hsp-47 inhibitors.

Katarkar A¹, Haldar PK², Chaudhuri K³.

Author information

Abstract

Heat shock protein-47 (Hsp-47) is exclusive collagen specific molecular chaperone involved in the maturation, processing and secretion of procollagen. Hsp-47 is consistently upregulated in several fibrotic diseases. Till date there is no potential antifibrotic small molecule drug available and Hsp-47 is known to be potential therapeutic target for fibrotic disorder and drug designing. We used the de novo drug design approach followed by pharmacophore generation and virtual screening to propose Hsp-47 based antifibrotic molecules. We used e-LEAD server for de novo drug design and ZINCPharmer for 3D pharmacophore generation and virtual screening. The virtually screened molecule may inhibit direct recruitment of collagen triple helix to interact with Hsp-47 and act as antifibrotic drug.

KEYWORDS:

De novo drug designing; Heat shock protein 47; Pharmacophore; Virtual screening

PMID:: 25522881; [PubMed – indexed for MEDLINE]

SOURCE

http://www.ncbi.nlm.nih.gov/pubmed/25522881

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64.

De novo design based pharmacophore query generation and virtual screening for the discovery of Hsp-47 inhibitors.

Katarkar A, Haldar PK, Chaudhuri K.

Biochem Biophys Res Commun. 2015 Jan 16;456(3):707-13. doi: 10.1016/j.bbrc.2014.12.051. Epub 2014 Dec 16.

PMID: 25522881 [PubMed – indexed for MEDLINE]

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Leaders in Pharmaceutical Business Intelligence Group, LLC, Doing Business As LPBI Group, Newton, MA

Posts Tagged ‘Proinflammatory cytokines’

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

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Leaders in Pharmaceutical Business Intelligence Group, LLC, Doing Business As LPBI Group, Newton, MA

Posts Tagged ‘Proinflammatory cytokines’

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

Collagen-binding Molecular Chaperone HSP47: Role in Intestinal Fibrosis – colonic epithelial cells and subepithelial myofibroblasts

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Abstract

KEYWORDS:

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