Funding, Deals & Partnerships: BIOLOGICS & MEDICAL DEVICES; BioMed e-Series; Medicine and Life Sciences Scientific Journal – http://PharmaceuticalIntelligence.com
Genetic scissors: a tool for rewriting the code of life
Emmanuelle Charpentier and Jennifer A. Doudna have discovered one of gene technology’s sharpest tools: the CRISPR/Cas9 genetic scissors. Using these, researchers can change the DNA of animals, plants and microorganisms with extremely high precision. This technology has had a revolutionary impact on the life sciences, is contributing to new cancer therapies and may make the dream of curing inherited diseases come true.
Researchers need to modify genes in cells if they are to find out about life’s inner workings. This used to be time-consuming, difficult and sometimes impossible work. Using the CRISPR/Cas9 genetic scissors, it is now possible to change the code of life over the course of a few weeks.
“There is enormous power in this genetic tool, which affects us all. It has not only revolutionised basic science, but also resulted in innovative crops and will lead to ground-breaking new medical treatments,” says Claes Gustafsson, chair of the Nobel Committee for Chemistry.
As so often in science, the discovery of these genetic scissors was unexpected. During Emmanuelle Charpentier’s studies of Streptococcus pyogenes, one of the bacteria that cause the most harm to humanity, she discovered a previously unknown molecule, tracrRNA. Her work showed that tracrRNA is part of bacteria’s ancient immune system, CRISPR/Cas, that disarms viruses by cleaving their DNA.
Charpentier published her discovery in 2011. The same year, she initiated a collaboration with Jennifer Doudna, an experienced biochemist with vast knowledge of RNA. Together, they succeeded in recreating the bacteria’s genetic scissors in a test tube and simplifying the scissors’ molecular components so they were easier to use.
In an epoch-making experiment, they then reprogrammed the genetic scissors. In their natural form, the scissors recognise DNA from viruses, but Charpentier and Doudna proved that they could be controlled so that they can cut any DNA molecule at a predetermined site. Where the DNA is cut it is then easy to rewrite the code of life.
Since Charpentier and Doudna discovered the CRISPR/Cas9 genetic scissors in 2012 their use has exploded. This tool has contributed to many important discoveries in basic research, and plant researchers have been able to develop crops that withstand mould, pests and drought. In medicine, clinical trials of new cancer therapies are underway, and the dream of being able to cure inherited diseases is about to come true. These genetic scissors have taken the life sciences into a new epoch and, in many ways, are bringing the greatest benefit to humankind.
Emmanuelle Charpentier, born 1968 in Juvisy-sur-Orge, France. Ph.D. 1995 from Institut Pasteur, Paris, France. Director of the Max Planck Unit for the Science of Pathogens, Berlin, Germany.
Jennifer A. Doudna, born 1964 in Washington, D.C, USA. Ph.D. 1989 from Harvard Medical School, Boston, USA. Professor at the University of California, Berkeley, USA and Investigator, Howard Hughes Medical Institute.
Other Articles on the Nobel Prize in this Open Access Journal Include:
On 3/31/2018 was nominated for 2018 Yidan Foundation Prize.
About the Yidan Prize
Founded in 2016 by Dr Charles CHEN Yidan, the Yidan Prize has a mission to create a better world through education. Through a series of initiatives – research, events and multimedia content – alongside the annual award, the prize serves to establish a platform that allows the global community to engage in conversation around education and to play a role in education philanthropy.
On 9/27/2018 The Yidan Prize Announces Laureates 2018:
The Yidan Prize’s laureates this year are Northwestern University’s Professor Larry HEDGES and eDX’s founder and CEO, Professor Anant AGARWAL.
Reflections on a Four-phase Career: Aviva Lev-Ari, PhD, RN, March 2018
Phase 2: Corporate Applied Research in the US, 1985 – 2005
Phase 3: Career Reinvention in Health Care, 2005 – 2012
Phase 4: Electronic Scientific Publishing, 4/2012 to Present
Phase 1: Research, 1973 – 1983
In Israel, Research Track
Masters level in the Urban Studies Department, HUJI, 1973-1976; thesis advisor: Prof. Amiram Gonen
Work and Welfare Research Institute (WWRI), HUJI, 1975-1976, research assistant to Prof. Shalom Reichman, WWRI director: Prof. Rivka W. Bar-Yosef, and
Technion, Transportation Research Center (TRC), 1977-1978, research associate and team leader, in Dr. Moshe Becker’s group, Road Safety Center (RSC).
My education at HUJI was crucial in attaining a Research Associate position at the Technion, 1977-1978. The years of research for my Masters at HUJI and the two years at the Technion contributed to my professional motivation and confidence to pursue a PhD at University of California, Berkeley, 9/1978 – 12/1983.
I arrived at my first research position at the Technion following my Masters at HUJI. I was extremely well prepared for the challenge. I was well versed in research methodologies and mastered advanced skills in scientific and technical oral and written communication. These most important skills served me very well three years later when I started my doctorate at University of California, Berkeley.
My professors at HUJI wrote recommendation letters for me which where critical for admission to the PhD program. I remained in contact with them till some passed away, Prof. Louis Guttman in 1989 and Prof. Shalom Reichman in 1994. I am in contact to this day with Prof. Ruth Kark, Dr. Shlomit Levy, and Dr. Sara Hershkovits. I was one of their very able students. On my annual visit in Israel, I meet with all the three.
In California, Doctoral Program at Berkeley, Industrial Organization Economics, Economic Geography, 9/1978 – 12/1983. Advisor: Prof. Allan Pred
Comments I made on 3/8/2018 to Nathan F. SAYRE, department chairman:
“The death of Allan Pred, was a colossal loss to humanity and to human geography. Like Albert Einstein’s death was an irrecoverable loss to the physics community and to the universe he researched and modeled!!!”
My own dissertation was creative and led to my first job in the US, after graduation, director level at SRI, International in Menlo Park, CA
Without the aura of a Berkeley PhD – I could not have been able to carry the torch that guided me to where I am in 2018, an owner of a knowledge-based venture with significant intellectual property, planning to transfer ownership in 2019/20.
I have expressed my feelings and impressions of my years at Berkeley in the following two articles:
Recollections: Part 1 – My days at Berkeley, 9/1978 – 12/1983 –About my doctoral advisor, Allan Pred, other Professors and other Peers
Phase 2: Corporate Applied Research in the US, 1985 – 2005
Twenty years of top-tier management consulting and as a corporate executive. In the corporate world, I worked for Fortune 50 companies, using the principles of statistical modeling, economic geography, and of industrial organization economics, every day.
Cardiovascular pharmacology-therapy research, development of a combination drug therapy, 2006-2007, Northeastern University, with Prof. Paul Aburjaily, PharmD
Editor-in-Chief of 13 Volumes of a 16-VolumeLPBI’s BioMed e-Series, published, 2013 – 2017, available on Amazon.com shelves in Medicine and Life Sciences. Three additional volumes will be published in 2018/9:
International Award for Human Genome Project, Volume 2 (Volume Two: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS and BioInformatics, Simulations and the Genome Ontology), Part 1: Next Generation Sequencing (NGS)
International Award for Human Genome Project
Reporter and Curator: Dr. Sudipta Saha, Ph.D.
The Thai royal family awarded its annual prizes in Bangkok, Thailand, in late January 2018 in recognition of advances in public health and medicine – through the Prince Mahidol Award Foundation under the Royal Patronage. This foundation was established in 1992 to honor the late Prince Mahidol of Songkla, the Royal Father of His Majesty King Bhumibol Adulyadej of Thailand and the Royal Grandfather of the present King. Prince Mahidol is celebrated worldwide as the father of modern medicine and public health in Thailand.
The Human Genome Project has been awarded the 2017 Prince Mahidol Award for revolutionary advances in the field of medicine. The Human Genome Project was completed in 2003. It was an international, collaborative research program aimed at the complete mapping and sequencing of the human genome. Its final goal was to provide researchers with fundamental information about the human genome and powerful tools for understanding the genetic factors in human disease, paving the way for new strategies for disease diagnosis, treatment and prevention.
The resulting human genome sequence has provided a foundation on which researchers and clinicians now tackle increasingly complex problems, transforming the study of human biology and disease. Particularly it is satisfying that it has given the researchers the ability to begin using genomics to improve approaches for diagnosing and treating human disease thereby beginning the era of genomic medicine.
National Human Genome Research Institute (NHGRI) is devoted to advancing health through genome research. The institute led National Institutes of Health’s (NIH’s) contribution to the Human Genome Project, which was successfully completed in 2003 ahead of schedule and under budget. NIH, is USA’s national medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases.
Building on the foundation laid by the sequencing of the human genome, NHGRI’s work now encompasses a broad range of research aimed at expanding understanding of human biology and improving human health. In addition, a critical part of NHGRI’s mission continues to be the study of the ethical, legal and social implications of genome research.
Nominations for 2016 National Academies Communication Awards For Excellence in Reporting and Communicating Sciences, Engineering, and Medicine, Keck Futures Initiative
Editor-in-Chief: Aviva Lev-Ari, PhD, RN
LPBI’s BioMed e-Series, 15 e-Books Titles in Medicine and Life Sciences on Amazon.com
Online Entry Summary (Please limit to 100 words): *
BioMed e-Series published in 2015 e-Books to popularize the Scientific findings of the frontier in Medicine and Life Sciences focusing on the top two Public HealthCare hazards: Cardiovascular Diseases and Cancer. The e-Series consists of medical interpretations of the most challenging causes of mortality and morbidities in Cancer Biology & Genomics for Disease Diagnosis, Genomics Orientations for Personalized Medicine, Metabolic Genomics and Pharmaceutics, the Milestones in Physiology: Discoveries in Medicine, Genomics and Therapeutics, the Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics. Precision Medicine as in Regenerative and Translational Medicine: The Therapeutics Promise for Cardiovascular Diseases.
ANNOUNCEMENT
Success – Thank You! Reference #: 9076095: The National Academies 2016 Communication Awards Nomination
I AM PROUD TO CONGRATULATE
Larry H Bernstein, MD, FCAP
Stephen J Williams, PhD
Tilda Barliya, PhD
Dror Nir, PhD
They constitute the TEAM that I nominated for
The National Academies 2016 Communication Awards, Keck Futures Initiative – Nomination
Category: Online
Subject for Nomination: BioMed e-Series published in 2015 by Leaders in Pharmaceutical Business Intelligence on Amazon.com
Milestones in Physiology: Discoveries in Medicine, Genomics and Therapeutics,
Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics,
Regenerative and Translational Medicine: The Therapeutics Promise for Cardiovascular Diseases
100 words
BioMed e-Series published in 2015 e-Books to popularize the Scientific findings of the frontier in Medicine and Life Sciences focusing on the top two Public HealthCare hazards: Cardiovascular Diseases and Cancer. The e-Series consists of medical interpretations of the most challenging causes of mortality and morbidities in Cancer Biology & Genomics for Disease Diagnosis, Genomics Orientations for Personalized Medicine, Metabolic Genomics and Pharmaceutics, the Milestones in Physiology: Discoveries in Medicine, Genomics and Therapeutics, the Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics. Precision Medicine as
LPBI’s BioMed e-Series was Submitted on 1/27/2016 for The National Academies of Sciences, Engineering, and Medicine
2016 Communication Awards For Excellence in Reporting and Communicating
Sciences, Engineering, and Medicine
The KeckFutures Initiative – a program of the National Academies of Sciences, Engineering, and Medicine, with the support of the W.M. Keck Foundation – will award four $20,000 prizes in 2016 to individuals or teams (up to four individuals associated with the creation of the work being nominated) who have developed creative, original works that address issues and advances in science, engineering and/or medicine for the general public. Nominations are accepted in four categories: Book; Film/Radio/TV; Magazine/Newspaper; and Online. The winners will be honored in the Fall 2016 and are expected to attend in person.
Magazine/Newspaper Entry Summary (Please limit to 100 words): *
In February 2012, a new venture was launched Doing Business As (DBA) Leaders in Pharmaceutical Business Intelligence. Founder, Pharmaceutical Business Intelligence Services is Aviva Lev-Ari, PhD, RN.
An online scientific EXCHANGE — an Open Access Online Scientific Journal for curation and reporting on frontiers in Biomedical, Genomics, Biological Sciences, Healthcare Economics, Pharmacology, Pharmaceutical & Medicine. The website, http://pharmaceuticalintelligence.com a scientific, medical and business multi expert authoring environment in LIFE SCIENCES, PHARMACEUTICAL, HEALTHCARE & MEDICINE INDUSTRIES.
1,879 are following our Journal, 868,702 views, 7,175 scientific comments 4,068 Scientific Articles, 472 Categories of Research, 8,267 Tags — ALL that is BioTech !!!!!!!!
Success – Thank You! Reference #: 9101075: Category Magazine/Newspaper -The National Academies 2016 Communication Awards Nomination
I AM HAPPY YO SHARE WITH YOU THE NOMINATION OF OUR OPEN ACCESS ONLINE SCIENTIFIC JOURNAL
In February 2012, a new venture was launched Doing Business As (DBA) Leaders in Pharmaceutical Business Intelligence. Founder, Pharmaceutical Business Intelligence Services is Aviva Lev-Ari, PhD, RN.
An online scientific EXCHANGE — an Open Access Online Scientific Journal for curation and reporting on frontiers in Biomedical, Genomics, Biological Sciences, Healthcare Economics, Pharmacology, Pharmaceutical & Medicine. The website, http://pharmaceuticalintelligence.com a scientific, medical and business multi expert authoring environment in LIFE SCIENCES, PHARMACEUTICAL, HEALTHCARE & MEDICINE INDUSTRIES.
1,879 are following our Journal, 868,702 views, 7,175 scientific comments 4,068 Scientific Articles, 472 Categories of Research, 8,267 Tags — ALL that is BioTech !!!!!!!!
2016 Communication Award – Excellence in Reporting and Communicating
Science, Medicine and Engineering
The KeckFutures Initiative – a program of the National Academies of Sciences, Engineering, and Medicine, with the support of the W.M. Keck Foundation – will award four $20,000 prizes in 2016 to individuals or teams (up to four individuals associated with the creation of the work being nominated) who have developed creative, original works that address issues and advances in science, engineering and/or medicine for the general public. Nominations are accepted in four categories: Book; Film/Radio/TV; Magazine/Newspaper; and Online. The winners will be honored in the Fall 2016 and are expected to attend in person.
Nomination of e-Book, Series A: Cardiovascular Diseases, Volume 2, Cases in Development of Scientific Curation Methodology
2016 Communication Awards Nomination Form Result #9143807
The National Academies of Sciences, Engineering, and Medicine
2016 Communication Awards for Excellence in Reporting and Communicating Science, Medicine and Engineering
Nomination Confirmation
Thank you for submitting a nomination for the 2016 National Academies Communication Awards. Below please find the supporting materials necessary for your nomination category, as well as the address to which they should be sent.
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Book
Book Title: *
Volume Two: Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation
Publisher(s): *
Amazon Kindle Direct
Publication Date: (Please select one): *
November 2015
Book Entry Summary (Please limit to 100 words): *
The explosion of scientific information has created difficulties tying together disparate discoveries, ideas, and potential applications. Pharmaceutical Business Intelligence is developing an innovative methodology for Global access to Biomedical knowledge rather than traditional search. To attain this complex goal they disseminate ORIGINAL Research via Content Curation by experts using critical thinking process & interpretation over open access networks, offering better organization and visibility of critical information useful for innovations in academic, clinical, and industrial research. Volume Two: Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation at http://www.amazon.com/dp/B018Q5MCN8 is nominated as an example of this methodology.
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Team
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Third-Party Nomination: I am nominating someone other than myself.
The Keck Futures Initiative – a Program of the National Academies of Sciences, Engineering, and Medicine – Submission of http://pharmaceuticalintelligence.com – Nomination Form Result #9101075 – 2016 Communication Award – Excellence in Reporting in Science, Medicine and Engineering
2016 Communication Award – Excellence in Reporting in Science, Medicine and Engineering
2016 Communication Awards Nomination Form Result #9101075
The KeckFutures Initiative – a program of the National Academies of Sciences, Engineering, and Medicine, with the support of the W.M. Keck Foundation – will award four $20,000 prizes in 2016 to individuals or teams (up to four individuals associated with the creation of the work being nominated) who have developed creative, original works that address issues and advances in science, engineering and/or medicine for the general public. Nominations are accepted in four categories: Book; Film/Radio/TV; Magazine/Newspaper; and Online. The winners will be honored in the Fall 2016 and are expected to attend in person.
Magazine/Newspaper Entry Summary (Please limit to 100 words): *
In February 2012, a new venture was launched Doing Business As (DBA) Leaders in Pharmaceutical Business Intelligence. Founder, Pharmaceutical Business Intelligence Services is Aviva Lev-Ari, PhD, RN.
An online scientific EXCHANGE — an Open Access Online Scientific Journal for curation and reporting on frontiers in Biomedical, Genomics, Biological Sciences, Healthcare Economics, Pharmacology, Pharmaceutical & Medicine. The website, http://pharmaceuticalintelligence.com a scientific, medical and business multi expert authoring environment in LIFE SCIENCES, PHARMACEUTICAL, HEALTHCARE & MEDICINE INDUSTRIES.
1,879 are following our Journal, 868,702 views, 7,175 scientific comments 4,068 Scientific Articles, 472 Categories of Research, 8,267 Tags — ALL that is BioTech !!!!!!!!
Title: *
Cancer Signaling Pathways and Tumor Progression: Images of Biological Processes in the Voice of a Pathologist Cancer Expert
Month of Publication: *
June
Day of Publication:
09
Year of Publication: *
2015
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Yes
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Other (Florence George Graves Founding Director The Schuster Institute for Investigative Journalism & The Justice Brandeis Law Project Brandeis University )
Review Action *
Please take a moment to review your nomination information being submitted. Once you click the “Submit” button your nomination will be submitted. Thank you and best of luck!
2016 Communication Awards Nomination Form Result #9143807
The National Academies of Sciences, Engineering, and Medicine
2016 Communication Awards Nomination Confirmation
Book
Book Title: *
Volume Two: Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation
Publisher(s): *
Amazon Kindle Direct
Publication Date: (Please select one): *
November 2015
Book Entry Summary (Please limit to 100 words): *
The explosion of scientific information has created difficulties tying together disparate discoveries, ideas, and potential applications. Pharmaceutical Business Intelligence is developing an innovative methodology for Global access to Biomedical knowledge rather than traditional search. To attain this complex goal they disseminate ORIGINAL Research via Content Curation by experts using critical thinking process & interpretation over open access networks, offering better organization and visibility of critical information useful for innovations in academic, clinical, and industrial research. Volume Two: Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation at http://www.amazon.com/dp/B018Q5MCN8 is nominated as an example of this methodology.
Are you nominating an individual or team (up to four individuals)? *
Team
Is this a self- or third-party nomination? *
Third-Party Nomination: I am nominating someone other than myself.
2012pharmaceutical
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