Personalized Medicine & Diagnostics, June 5, 11-12, BIO 2018! Boston, BCEC
Reporter: Aviva Lev-Ari, PhD, RN
11:00 AM–12:00 PM Jun 5, 2018
Personalized Medicine & Diagnostics
Precision Medicine Coming of Age with Dr. Raju Kucherlapati, Paul C. Cabot Professor of Genetics and Professor of Medicine, Harvard Medical School
- Ed Abrams, President PMC – 13% of American are adequately informed on Personalized Medicine. Supporting infrastructure, Scientific and public
Speakers
- Precision Medicine & Personalized Medicine (PM-PM)
- cloning gene for CF took 10 years
- 1990 – Human Genome Program – NIH – sequence the entire Human Genome – for improving disease
- completed in 2000 at $2.5 Billion cost – NIH
- Illumina – second company to sequence CHinese company will be able to sequence Human Genome for $600
- Physicians were excited about the Human genome sequencing for PM-PM
- Millenium , Celera,
- Genetech – 1998 – Receptin – subset of women Breast Cancer over expression of a gene BR
- Cancer drug 2001 – Reva – Novartis, CML – only patients with good outocme increased from 30% to 98%
- Gleevac – is a Blockbuster drug – encouraged development of drugs for rare disease
- Prevention of Disease – detect at-risk patients, i.e., CF
- Meryad Genetics acquired a company that developed technology to detect at-risk in multiple genes not one at a time
- Amniotic fluid carry fetal DNA — Testing developed to detect fetal disorders
- Detection at pre-natal stages of multiple fetal disorders, abnormality, diagnosis drive treatment – genetic testing critical in cost containment
- Cardiomayopaty: in Young athlete genetic disorder, other are related to increased age, 100 genes are involved in right side heart enlargement
- 10% of Lung Cancer Patients responded to treatment in 2004 – genetic based drug is prescribed only to Patient with EGFR – all positively respond
- Immune therapies initially in melanoma, improvement in progression pre-survival – if free of Cancer over 5 yeras, patient considered ot be cured
- Mutation burden measures – drug approved based on probability of positive response
- Reimbursement – CMS – determineat the National level appproved test in Cancers for reimbursement – it was a challenge
- Database with million of people with genetic and medical information — searches of profile too group patients for optimal drug matching, integration of EMR with DB of genetics – IBM technologies, Google, Amazon, Microsoft – integrate information
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Amandeep Kaur
Aashir Awan, Phd
Abhisar Anand
Adina Hazan
Alan F. Kaul, PharmD., MS, MBA, FCCP
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David Orchard-Webb, PhD
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Demet Sag, Ph.D., CRA, GCP
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Ethan Coomber
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