Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Cold Spring Harbor Conference Meetings

Larry H. Bernstein, MD, FCAP, Curator

LPBI

Cold Spring Harbor Meetings

1. “MicroRNAs in aging” from the Molecular Basis of Aging and Disease meeting CSHL ASIA 9/17/2015

CSHL Keynote; Dr. Frank Slack, Harvard Medical School

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/YuRUBBSOZxw/mqdefault.webp

2. Dorcus Cummings Lecture “The Genetic Legacy of Neanderthals” from the 80th Symposium: 21st Century Genetics – Genes at Work 5/30/15

CSHL Keynote, Dr Svante Paabo, Max-Planck-Institute

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/GS8CT92rL4A/mqdefault.webp

3. “Neuron-glia metabolic coupling—Relevance for neuronal plasticity and functional brain imaging” from the New Insights into Glia Function and Dysfunction meeting, Suzhou China

CSHL Keynote Series; Dr. Pierre J Magistretti, University of Lausanne

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/eaWiElwsof0/mqdefault.webp

4. 2015 Cold Spring Harbor Symposium
   21st Century Genetics:

CSHL 2015 Symposium Interview Series with Emmanuelle Charpentier

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/H5Xaa1T4GB0/mqdefault.webp

5. 2015 Cold Spring Harbor Symposium
   21st Century Genetics:

 13:33

CSHL 2015 Symposium Interview Series with Joanna Wysocka

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/MDOL2SaI5-M/mqdefault.webp

6. 2015 Cold Spring Harbor Symposium
   21st Century Genetics:

CSHL 2015 Symposium Interview Series wth Wolf Reik

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/hROna-Wyz7Y/mqdefault.webp

7. 2015 Cold Spring Harbor Symposium
   21st Century Genetics:

CSHL 2015 Symposium Interview Series with Susan Lindquist

by CSHL Leading Strand
https://i.ytimg.com/vi_webp/OC3l1UI9CZg/mqdefault.webp

8. 2015 Cold Spring Harbor Symposium
   21st Century Genetics:

CSHL 2015 Symposium Interview Series with Richard Young

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/z7jNOeo4DNU/mqdefault.webp

9. 2015 Cold Spring Harbor Symposium
   21st Century Genetics:

CSHL 2015 Symposium Interviews with Svante Pääbo

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/qMkKWovOYkY/mqdefault.webp

10. 2015 Cold Spring Harbor Symposium
    21st Century Genetics:

CSHL 2015 Interview Series with Anne Ferguson-Smith

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/trwQ71bAW7o/mqdefault.webp

11. 2015 Cold Spring Harbor Symposium
    21st Century Genetics:

CSHL 2015 Symposium Interview Series with Jennifer Doundna

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/xwXBmsGOp-M/mqdefault.webp

12. 2015 Cold Spring Harbor Symposium
    21st Century Genetics:

CSHL 2015 Symposium Interview Series with Job Dekker

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/d6sYIfxu9bI/mqdefault.webp

13. 2015 Cold Spring Harbor Symposium
    21st Century Genetics:

CSHL 2015 Symposium Interview Series with Julius Brennecke

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/4e9LpoxqnuA/mqdefault.webp

14. “Mendelian randomization: Harnessing genocopy/phenocopy to identify modifiable causes of disease” from the Biology of Genomes meeting 5/8/2015

CSHL Keynote; Dr George Davey Smith, University of Bristol

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/PvHKBCYwMnY/mqdefault.webp

15. 2015 Cold Spring Harbor Symposium
    21st Century Genetics:

CSHL 2015 Symposium Interview Series with Titia de Lange

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/YOGLD2Iz02k/mqdefault.webp

16. “Ubiquitin and Autophagy Networks” from the The Ubiquitin Family meeting April 24, 2015

CSHL Keynote; Dr Ivan Dikic, Goethe University Medical School

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/UsKZiZWPr8w/mqdefault.webp

17. “How biology optimizes both specificity and efficiency—Single molecule studies of ubiquitylation” from the Cellular Dynamics & Models meeting 3/4/2015

CSHL Keynote; Dr. Marc Kirschner, Harvard Medical School

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/xhRhkYxroT4/mqdefault.webp

18. The Glymphatic System” from the Blood Brain Barrier meeting 12/12/2014

CSHL Keynote, Dr. Maiken Nedergaard, University of Rochester Medical Center

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/S-JXgPUmd3A/mqdefault.webp

19. Pushing the scale of genetic engineering” from the Synthetic Biology meeting in Suzhou China, CSHL-Asia 12/2/2014

CSHL Keynote Series, Dr. Christopher Voight, Massachusetts Institute of Technology

by CSHL Leading Strand

https://i.ytimg.com/vi_webp/tRXS7xMvep0/mqdefault.webp

Quantitative Biology

2012 Cold Spring Harbor Asia Conference on Synthetic Biology

Hongyu Zhao*

http://dx.doi.org/10.1007/s40484-013-0010-6

Keynote speeches

In the first keynote speech, Birger Lindberg Møller presented a lecture on “Plant power: the ultimate way to go green”. Plant can produce bioactive defense compounds when attacked by insects and microbes. Several of these compounds are used in the treatment of human diseases including cancer. They use the “share-your-parts” principle of synthetic biology to

promote the production of bioactive compounds that are difficult or impossible to synthesize using chemical methods. The second keynote speaker, Lars K. Nielsen presented “Metabolic and regulatory models for synthetic biology design”. He reviewed the status of rational in-silico strain design, providing a cost effective way of constructing metabolic pathways for making biocompounds. The last keynote speaker Sven Panke provided promises and ambition on technical advances as well as on a conceptual rethinking of how we design biocatalysts. He illustrated principles of designing biocatalysts with examples from his own work on nanoand pico-liter reactor design for screening purposes, on real-time mass spectrometry for pathway analysis and optimization, and protein switching for orthogonal in vitro pathways.

Prokaryotic genome engineering

Yu-Sin Jang (KAIST, Korea) reported that the direct butanol-forming pathway is a better channel for optimization of butanol production. An interesting topic was shared by Akio Kawahara-Kobayash (Tokyo Institute of Technology, Japan). At earlier stages in the evolution of the universal genetic code, fewer than 20 amino acids were considered for use. They made artificial genetic codes involving a reduced alphabet to provide not only new insights into primordial genetic codes, but also an essential protein engineering tool for the assessment of the early stages of protein evolution and for the improvement of pharmaceuticals. To meet the demands of industrial production, microbes should maintain a maximized and fixed carbon flux towards target metabolites regardless of fluctuations in intracellular or extracellular environments.