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Twitter is Becoming a Powerful Tool in Science and Medicine

Posted in Academic Publishing, Clinical Diagnostics, Computational Biology/Systems and Bioinformatics, Conference Coverage with Social Media, Curation, Curation methodology, Digital HealthCare – biotech & internet joint ventures, Drug Toxicity, Evolutionary cognition, FDA, FDA Regulatory Affairs, Global Partnering & Biotech Investment, Health Economics and Outcomes Research, HealthCare IT, Interviews with Scientific Leaders, Investment in Technological Breakthrough, Personal Health Applications: Tech Innovations serves HealhCare, Pharmaceutical Analytics, Pharmaceutical Discovery, Pharmacologic toxicities, Regulated Clinical Trials: Design, Methods, Components and IRB related issues, Scientific & Biotech Conferences: Press Coverage, tagged #mobilehealth, #science2_0, @science 2_0, Adverse event, Aviva Lev-Ari, Cancer - General, cancer patient management, Clinical trial, Conditions and Diseases, Conference Coverage with Social Media, Content Curation, Curation methodology, Food and Drug Administration, health, https://twitter.com/#!/pharma_BI, medical devices and digital health, medicine, mobile applications, patient outcomes, patient-interaction, Pharmacovigilance, research, science, Social media, Social network, Twitter on November 6, 2014| Leave a Comment »

Twitter is Becoming a Powerful Tool in Science and Medicine

 Curator: Stephen J. Williams, Ph.D.

Article ID #159: Twitter is Becoming a Powerful Tool in Science and Medicine. Published on 11/6/2014

WordCloud Image Produced by Adam Tubman

Updated 4/2016

Twitter.com

A recent Science article (Who are the science stars of Twitter?; Sept. 19, 2014) reported the top 50 scientists followed on Twitter. However, the article tended to focus on the use of Twitter as a means to develop popularity, a sort of “Science Kardashian” as they coined it. So the writers at Science developed a “Kardashian Index (K-Index) to determine scientists following and popularity on Twitter.

Now as much buzz Kim Kardashian or a Perez Hilton get on social media, their purpose is solely for entertainment and publicity purposes, the Science sort of fell flat in that it focused mainly on the use of Twitter as a metric for either promotional or public outreach purposes. A notable scientist was mentioned in the article, using Twitter feed to gauge the receptiveness of his presentation. In addition, relying on Twitter for effective public discourse of science is problematic as:

• Twitter feeds are rapidly updated and older feeds quickly get buried within the “Twittersphere” = LIMITED EXPOSURE TIMEFRAME
• Short feeds may not provide the access to appropriate and understandable scientific information (The Science Communication Trap) which is explained in The Art of Communicating Science: traps, tips and tasks for the modern-day scientist. “The challenge of clearly communicating the intended scientific message to the public is not insurmountable but requires an understanding of what works and what does not work.” – from Heidi Roop, G.-Martinez-Mendez and K. Mills

However, as highlighted below, Twitter, and other social media platforms are being used in creative ways to enhance the research, medical, and bio investment collaborative, beyond a simple news-feed.  And the power of Twitter can be attributed to two simple features

1. Ability to organize – through use of the hashtag (#) and handle (@), Twitter assists in the very important task of organizing, indexing, and ANNOTATING content and conversations. A very great article on Why the Hashtag in Probably the Most Powerful Tool on Twitter by Vanessa Doctor explains how hashtags and # search may be as popular as standard web-based browser search. Thorough annotation is crucial for any curation process, which are usually in the form of database tags or keywords. The use of # and @ allows curators to quickly find, index and relate disparate databases to link annotated information together. The discipline of scientific curation requires annotation to assist in the digital preservation, organization, indexing, and access of data and scientific & medical literature. For a description of scientific curation methodologies please see the following links:

Please read the following articles on CURATION

The Methodology of Curation for Scientific Research Findings

Power of Analogy: Curation in Music, Music Critique as a Curation and Curation of Medical Research Findings – A Comparison

Science and Curation: The New Practice of Web 2.0

2. Information Analytics –

Multiple analytic software packages have been made available to analyze information surrounding Twitter feeds, including Twitter feeds from #chat channels one can set up to cover a meeting, product launch etc.. Some of these tools include:

Twitter Analytics – measures metrics surrounding Tweets including retweets, impressions, engagement, follow rate, …

Twitter Analytics – Hashtags.org – determine most impactful # for your Tweets For example, meeting coverage of bioinvestment conferences or startup presentations using #startup generates automatic retweeting by Startup tweetbot @StartupTweetSF.

 

3. Tweet Sentiment Analytics

Examples of Twitter Use

A. Scientific Meeting Coverage

• The 2013 Society of Teachers of Family Medicine Annual Spring Conference. integrated social media with meeting proceedings to enhance conference engagement

In a paper entitled Twitter Use at a Family Medicine Conference: Analyzing #STFM13 authors Ranit Mishori, MD, Frendan Levy, MD, and Benjamin Donvan analyzed the public tweets from the 2013 Society of Teachers of Family Medicine (STFM) conference bearing the meeting-specific hashtag #STFM13. Thirteen percent of conference attendees (181 users) used the #STFM13 to share their thoughts on the meeting (1,818 total tweets) showing a desire for social media interaction at conferences but suggesting growth potential in this area. As we have also seen, the heaviest volume of conference-tweets originated from a small number of Twitter users however most tweets were related to session content.

However, as the authors note, although it is easy to measure common metrics such as number of tweets and retweets, determining quality of engagement from tweets would be important for gauging the value of Twitter-based social-media coverage of medical conferences.

Thea authors compared their results with similar analytics generated by the HealthCare Hashtag Project, a project and database of medically-related hashtag use, coordinated and maintained by the company Symplur.  Symplur’s database includes medical and scientific conference Twitter coverage but also Twitter usuage related to patient care. In this case the database was used to compare meeting tweets and hashtag use with the 2012 STFM conference.

These are some of the published journal articles that have employed Symplur (www.symplur.com) data in their research of Twitter usage in medical conferences.

• The impact of social media on a major international emergency medicine conference.
  Neill, A., Cronin, J. J., Brannigan, D., O’Sullivan, R., & Cadogan, M. (2013). The impact of social media on a major international emergency medicine conference. Emergency Medicine Journal, emermed-2012. Chicago
• Social media in radiology: early trends in Twitter microblogging at radiology’s largest international meeting.
  Hawkins, C. M., Duszak, R., & Rawson, J. V. (2014). Social Media in Radiology: Early Trends in Twitter Microblogging at Radiology’s Largest International Meeting. Journal of the American College of Radiology, 11(4), 387-390.
• International Urology Journal Club via Twitter: 12-Month Experience.
  Thangasamy, I. A., Leveridge, M., Davies, B. J., Finelli, A., Stork, B., & Woo, H. H. (2014). International Urology Journal Club via Twitter: 12-Month Experience. European urology.
• Use of social media in urology: data from the American Urological Association (AUA).
  Loeb, S., Bayne, C. E., Frey, C., Davies, B. J., Averch, T. D., Woo, H. H., … & Eggener, S. E. (2014). Use of social media in urology: data from the American Urological Association (AUA). BJU international, 113(6), 993-998. Chicago.
• Social media: A tool to spread information: A case study analysis of Twitter conversation at the Cardiac Society of Australia & New Zealand 61st Annual Scientific Meeting 2013.
  Ferguson, C., Inglis, S. C., Newton, P. J., Cripps, P. J., Macdonald, P. S., & Davidson, P. M. (2014). Social media: A tool to spread information: A case study analysis of Twitter conversation at the Cardiac Society of Australia & New Zealand 61st Annual Scientific Meeting 2013. Collegian.

• Here, at Leaders in Pharmaceutical Business Intelligence (LBPI) we have integrated our web site, Twitter handle (@pharma_BI), and meeting specific hashtags, with a unique methodology, to monitor and measure meeting participant engagement for various international meetings (please see our Press Coverage section of our site for more information). These meetings included the 2nd Annual Sachs Associates Cancer BioInvestment & Partnering Forum and the 14^th Annual Sachs Associates Global Forum.

B. Twitter Usage for Patient Care and Engagement

Although the desire of patients to use and interact with their physicians over social media is increasing, along with increasing health-related social media platforms and applications, there are certain obstacles to patient-health provider social media interaction, including lack of regulatory framework as well as database and security issues. Some of the successes and issues of social media and healthcare are discussed in the post Can Mobile Health Apps Improve Oral-Chemotherapy Adherence? The Benefit of Gamification.

However there is also a concern if social media truly engages the patient and improves patient education. In a study of Twitter communications by breast cancer patients Tweeting about breast cancer, authors noticed Tweeting was a singular event. The majority of tweets did not promote any specific preventive behavior. The authors concluded “Twitter is being used mostly as a one-way communication tool.” (Using Twitter for breast cancer prevention: an analysis of breast cancer awareness month. Thackeray R¹, Burton SH, Giraud-Carrier C, Rollins S, Draper CR. BMC Cancer. 2013;13:508).

In addition a new poll by Harris Interactive and HealthDay shows one third of patients want some mobile interaction with their physicians.

Some papers cited in Symplur’s HealthCare Hashtag Project database on patient use of Twitter include:

• e-Patients in Twitter Hashtag Communities.
  Harmel M, Young K. e-Patients in twitter hashtag communities . J Participat Med. 2013 Jan 16; 5:e22
• Nurses and Twitter: The good, the bad, and the reluctant.
  Wilson, R., Ranse, J., Cashin, A., & McNamara, P. (2013). Nurses and Twitter: The good, the bad, and the reluctant. Collegian. Chicago.
• Using social media for continuous professional development.
  Moorley, C., & Chinn, T. (2014). Using social media for continuous professional development. Journal of advanced nursing.
• Networking opportunities for learning disability nurses.
  Abdulla, S., Marsden, D., Wilson, S., & Parker, M. (2013). Networking opportunities for learning disability nurses: Samuel Abdulla and colleagues explain why social media offer professionals new opportunities for information sharing, discussion and peer support. Learning Disability Practice, 16(5), 30-32.
• Using Twitter for professional knowledge.
  Kraft, M. A. (2013). Using Twitter for professional knowledge. Journal of the European Association for Health Information and Libraries, 9(4), 10.
• A Study on the Influence of Semantics on the Analysis of Micro-blog Tags in the Medical Domain.
  Vicient, C., & Moreno, A. (2013). A Study on the Influence of Semantics on the Analysis of Micro-blog Tags in the Medical Domain. In Availability, Reliability, and Security in Information Systems and HCI (pp. 446-459). Springer Berlin Heidelberg.
• Twitter for Public Health: An Open-source Data Solution.
  Nghiema, S., Mehtab, P., & Taoc, L. Twitter for Public Health: An Open-source Data Solution. Chicago.

C. Twitter Use in Pharmacovigilance to Monitor Adverse Events

Pharmacovigilance is the systematic detection, reporting, collecting, and monitoring of adverse events pre- and post-market of a therapeutic intervention (drug, device, modality e.g.). In a Cutting Edge Information Study, 56% of pharma companies databases are an adverse event channel and more companies are turning to social media to track adverse events (in Pharmacovigilance Teams Turn to Technology for Adverse Event Reporting Needs). In addition there have been many reports (see Digital Drug Safety Surveillance: Monitoring Pharmaceutical Products in Twitter) that show patients are frequently tweeting about their adverse events.

There have been concerns with using Twitter and social media to monitor for adverse events. For example FDA funded a study where a team of researchers from Harvard Medical School and other academic centers examined more than 60,000 tweets, of which 4,401 were manually categorized as resembling adverse events and compared with the FDA pharmacovigilance databases. Problems associated with such social media strategy were inability to obtain extra, needed information from patients and difficulty in separating the relevant Tweets from irrelevant chatter.  The UK has launched a similar program called WEB-RADR to determine if monitoring #drug_reaction could be useful for monitoring adverse events. Many researchers have found the adverse-event related tweets “noisy” due to varied language but had noticed many people do understand some principles of causation including when adverse event subsides after discontinuing the drug.

However Dr. Clark Freifeld, Ph.D., from Boston University and founder of the startup Epidemico, feels his company has the algorithms that can separate out the true adverse events from the junk. According to their web site, their algorithm has high accuracy when compared to the FDA database. Dr. Freifeld admits that Twitter use for pharmacovigilance purposes is probably a starting point for further follow-up, as each patient needs to fill out the four-page forms required for data entry into the FDA database.

D. Use of Twitter in Big Data Analytics

Published on Aug 28, 2012

http://blogs.ischool.berkeley.edu/i29…

Course: Information 290. Analyzing Big Data with Twitter
School of Information
UC Berkeley

Lecture 1: August 23, 2012

Course description:
How to store, process, analyze and make sense of Big Data is of increasing interest and importance to technology companies, a wide range of industries, and academic institutions. In this course, UC Berkeley professors and Twitter engineers will lecture on the most cutting-edge algorithms and software tools for data analytics as applied to Twitter microblog data. Topics will include applied natural language processing algorithms such as sentiment analysis, large scale anomaly detection, real-time search, information diffusion and outbreak detection, trend detection in social streams, recommendation algorithms, and advanced frameworks for distributed computing. Social science perspectives on analyzing social media will also be covered.

This is a hands-on project course in which students are expected to form teams to complete intensive programming and analytics projects using the real-world example of Twitter data and code bases. Engineers from Twitter will help advise student projects, and students will have the option of presenting their final project presentations to an audience of engineers at the headquarters of Twitter in San Francisco (in addition to on campus). Project topics include building on existing infrastructure tools, building Twitter apps, and analyzing Twitter data. Access to data will be provided.

Other posts on this site on USE OF SOCIAL MEDIA AND TWITTER IN HEALTHCARE and Conference Coverage include:

Methodology for Conference Coverage using Social Media: 2014 MassBio Annual Meeting 4/3 – 4/4 2014, Royal Sonesta Hotel, Cambridge, MA

Strategy for Event Joint Promotion: 14th ANNUAL BIOTECH IN EUROPE FORUM For Global Partnering & Investment 9/30 – 10/1/2014 • Congress Center Basel – SACHS Associates, London

REAL TIME Cancer Conference Coverage: A Novel Methodology for Authentic Reporting on Presentations and Discussions launched via Twitter.com @ The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum in Drug Development, 19th March 2014 • New York Academy of Sciences • USA

PCCI’s 7th Annual Roundtable “Crowdfunding for Life Sciences: A Bridge Over Troubled Waters?” May 12 2014 Embassy Suites Hotel, Chesterbrook PA 6:00-9:30 PM

CRISPR-Cas9 Discovery and Development of Programmable Genome Engineering – Gabbay Award Lectures in Biotechnology and Medicine – Hosted by Rosenstiel Basic Medical Sciences Research Center, 10/27/14 3:30PM Brandeis University, Gerstenzang 121

Tweeting on 14th ANNUAL BIOTECH IN EUROPE FORUM For Global Partnering & Investment 9/30 – 10/1/2014 • Congress Center Basel – SACHS Associates, London

http://pharmaceuticalintelligence.com/press-coverage/

Statistical Analysis of Tweet Feeds from the 14th ANNUAL BIOTECH IN EUROPE FORUM For Global Partnering & Investment 9/30 – 10/1/2014 • Congress Center Basel – SACHS Associates, London

1st Pitch Life Science- Philadelphia- What VCs Really Think of your Pitch

What VCs Think about Your Pitch? Panel Summary of 1st Pitch Life Science Philly

How Social Media, Mobile Are Playing a Bigger Part in Healthcare

Can Mobile Health Apps Improve Oral-Chemotherapy Adherence? The Benefit of Gamification.

Medical Applications and FDA regulation of Sensor-enabled Mobile Devices: Apple and the Digital Health Devices Market

E-Medical Records Get A Mobile, Open-Sourced Overhaul By White House Health Design Challenge Winners

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CRISPR-Cas9 Discovery and Development of Programmable Genome Engineering – Gabbay Award Lectures in Biotechnology and Medicine – Hosted by Rosenstiel Basic Medical Sciences Research Center, 10/27/14 3:30PM Brandeis University, Gerstenzang 121

Posted in Academic Publishing, Conference Coverage with Social Media, Gene Regulation, Gene Regulation and Evolution, Genetics & Pharmaceutical, Genomic Testing: Methodology for Diagnosis, Genomics Pharmacy, Immunodiagnostics, Infectious Disease & New Antibiotic Targets, Infectious Disease Immunodiagnostics, Innovation in Immunology Diagnostics, Intellectual Property, Intellectual Property, Innovations, Commercialization, Investment in technological breakthrough, Interviews with Scientific Leaders, Molecular Genetics & Pharmaceutical, Personalized and Precision Medicine & Genomic Research, Pharmacogenomics, Population Health Management, Genetics & Pharmaceutical, Proteomics, RNA Biology, RNA Biology, Cancer and Therapeutics, Scientific & Biotech Conferences: Press Coverage on October 26, 2014| Leave a Comment »

LIVE – Now –>> CRISPR-Cas9 Discovery and Development of Programmable Genome Engineering – Gabbay Award Lectures in Biotechnology and Medicine – Hosted by Rosenstiel Basic Medical Sciences Research Center, 10/27/14 3:30PM Brandeis University, Gerstenzang 121

Reporter: Aviva Lev-Ari, PhD, RN

Article ID #157: Article ID #159: CRISPR-Cas9 Discovery and Development of Programmable Genome Engineering – Gabbay Award Lectures in Biotechnology and Medicine – Hosted by Rosenstiel Basic Medical Sciences Research Center, 10/27/14 3:30PM Brandeis University, Gerstenzang 121. Published on 10/26/2014

WordCloud Image Produced by Adam Tubman

REAL TIME Conference Coverage by Dr. Aviva Lev-Ari, PhD, RN

For more Biotech Conferences Covered in Real Time by Dr. Aviva Lev-Ari, PhD, RN for Leaders in Pharmaceutical Business Intelligence using Social Media and Open Access Online Scientific Journal http://pharmaceuticalintelligence.com

click on

http://pharmaceuticalintelligence.com/press-coverage/

For articles on CRISPR-Cas9 in Open Access Online Scientific Journal http://pharmaceuticalintelligence.com

click on

http://pharmaceuticalintelligence.com/?s=CRISPR-Cas9

 

LIVE CONTENT from 

Gabbay Award Lecture in Biotechnology and Medicine @Brandeis

is been added 0n 10/27 @3;30PM

InVivo Target Search Mechanism – Fast Cas9 Diffusion in Live Cells

First Speaker

Emmanuelle Charpentier (Dept. of Molecular Biology. Umea University; Dept. of Regulation in Infection Biology, Helmholtz Centre for Infection Research)

CRISPR-Cas9: How a Bacterial Immune System Revolutionizes Life Sciences and Medicine

application in dairy industry basilicum, bacteria

Second Speaker

Jennifer Doudna (Dept. of Biochemistry, Biophysics and Structural Biology, UC Berkeley)CRISPR-Cas9 Discovery and Development of Programmable Genome Engineering

Bacterial/archaeal chromosome

a single gene CAs9m- enzyme single-guide RNAs (sgRNAs)

crRNA

A Programmable Dual-RNA- Genome editing begins with dsDNA cleavange

ZFHs, TALENs, HEs, Cas9:sgRNA

protein DNA recognition

Genome targeting technologies: ZFN & TALEN

/Cas9/targeting RNA bound by a nuclease

2012-RNA-guided DNA endonuclease

1/2013 Church, Zhang

Re-Writing the Genome:

DNA structu

restriction enzymes

PCR

Specific genome editing in cell and in organizmism

robust transcriptional control with ccatalyrtic

In the Lab @Berkeley

Hoe Cas9 find DNA targets with high specificity

Mechanism of DNA interrogation

• high affinity product binding, no substrate turnover
• binding first occur at PAM motifs
• PAM binding triggers Cas9 catalytic activity

CRISPR: Clusters of Regulary

three steps to acquire immunity in bacteria

1. adaptation

2. crRNA biogenesis

3. Interference

CRISPR in Structural Biology

• RNA-induced conversion of Cas9 into an active confrontation – crystal structure morphology

Models for DNA interrogation by Cas9:RNA

Programmed RNA cleavage using Cas9:gRNA in O’Connell at al. (2014) Nature

 

• Therapeutic Applications

1. Delivery of antibiotic small molecule

2. Animal models live cell (catalitic inactive version vs active version)

 

Third Speaker

Feng Zhang (McGovern Inst. for Brain Research, MIT)
Development and Applications of CRISPR-Cas9 for Genome Editing

Brain Research – Applications for CRISPER

• Genetics & epigenetics
• signals – optogenetics Neuromodulation
• optogenetics — fibers — cells

The CRISPR/Cas bacterial

Crispr RNA maturation

E.coli – immunity for using Crispr

Streptococcus thermophilus – CRISPr editing applied

Development of a Technology Platform

• expand modes of Genomic Pertubation

develop efficient co-transduction of primary neurons

multiplex knockout un the denate

• demonstrate uses in biological therapeutic context

CRISPR — Reagents development, protocol developed, discussion forums

targeting of MeCP2 gyrus leads to robust protein depletion and behavior change

toxicity potential researched

Cre-dedendent CAs9 MOUSE FOR CANCER MODELING – mouth lung

• develop an open source for the community

Genome-scale CRISPR knockout (GeCKO) Screen – generate library pool of cell – mutation identification – melanoma treated by BRAF inhibitor – targets for menanoma resistence

Comparison of shRNA vs GeCKO – CRISPR more robust and statisticaly significant, However, GeCKO provides higher sensitivity than shRNA

•  foundational technology development

Crystal structure of Cas9 in complex wiht guided RNA and target DNA

Cre-dependent Cas9 Mouse

 

For Twitter.com

#Cas9
#CRISPR
#molecularbiology
#biotechnology
#GeneEditing
#genetic#engineering (sometimes these two # are put together like this)
#Boston

@BrandeisU
@MIT
@UCBerkeley
@CRISPRpapers
@UmeaUniversity
@mcgovernmit (this is for Feng Zhang)
@pharma_BI

 

CRISPR Service / Cas9

Commercialization by

 http://www.appliedstemcell.com/services/cell-line-models/cell-line-modification/

The CRISPR/Cas9 system uses the Cas9 nuclease to facilitate RNA-guided site-specific DNA cleavage. The system consists of two components:

(1) Mammalian codon-optimized version of the Cas9 protein carrying a nuclear localization signal to ensure nuclear compartmentalization in mammalian cells

(2) Guide RNAs (gRNAs) to direct Cas9 protein to sequence-specifically cleave the targeted DNA

The advantage of CRISPR/Cas9 over ZFNs or TALENs is its scalability and multiplexibility in that multiple sites within the mammalian genome can be simultaneously modified, providing a robust, high-throughput approach for gene editing in mammalian cells.

CRISPR Service (Point mutation, Deletion, Small DNA insertion)

We are experts in CRISPR Service! Applied StemCell is in Nature Biotechnology as one of the select companies for CRISPR-Cas9 tools! Monya Baker, “Gene Editing at CRISPR Speed,” Nature Biotechnology, 32: 309-312, April 2014.

Since Applied Stem Cell started out as a company focused on induced pluripotent stem cells (iPSCs), we have excellent capabilities of correcting mutations in disease-model iPSCs using CRISPR/ Cas9.

 

 

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