WordCloud Visualization of LPBI’s Top Sixteen Articles on GENOMICS by Views at All Time and their Research Categories in the Ontology of PharmaceuticalIntelligence.com
Curators: Stephen J. Williams, Aviva Lev-Ari, PhD, RN and WordCloud Producers: Daniel Menzin, Noam Steiner-Tomer, Zach Day, Ofer Markman, PhD
Now we will do the same for Genomics Volume I so for your pre class homework first read the following electronic Table of Contents
and then determine some themes around the table of contents into a mind map of what you think are the scientists/clinicians main themes on the field of Genomics
Genomics eTOC at
https://pharmaceuticalintelligence.com/biomed-e-books/genomics-orientations-for-personalized-medicine/volume-one-genomics-orientations-for-personalized-medicine/
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One
Image Collage by SJ Williams, PhD, Google Images in Assembly
Larry H Bernstein, MD, FCAP, Senior Editor
Triplex Medical Science, Trumbull, CT
Larry.bernstein@gmail.com
and
Stephen J. Williams, PhD , Editor
Leaders in Pharmaceutical Business Intelligence , Philadelphia
sjwilliamspa@comcast.net
and
Aviva Lev-Ari, PhD, RN , Editor
Editor-in-Chief BioMed E-Book Series
Leaders in Pharmaceutical Business Intelligence, Boston
avivalev-ari@alum.berkeley.edu
Article Title (Live Link )All Time Views Categories of Research #1Big Data in Genomic Medicine 696 Bio Instrumentation in Experimental Life Sciences Research , Chemical Biology and its relations to Metabolic Disease , Chemical Genetics , Computational Biology/Systems and Bioinformatics , Genome Biology , Genomic Testing: Methodology for Diagnosis , Molecular Genetics & Pharmaceutical , Personalized and Precision Medicine & Genomic Research , Population Health Management, Genetics & Pharmaceutical , Statistical Methods for Research Evaluation , Technology Transfer: Biotech and Pharmaceutical
#1
Big Data in Genomic Medicine
Article #1: Word Cloud by NT
Article Title (Live Link )All Time Views Categories of Research #2Unraveling Retrograde Signaling Pathways ~57 Biological Networks, Gene Regulation and Evolution , Cell Biology, Signaling & Cell Circuits , Computational Biology/Systems and Bioinformatics , Disease Biology, Small Molecules in Development of Therapeutic Drugs , Genome Biology , International Global Work in Pharmaceutical , Personalized and Precision Medicine & Genomic Research , Pharmaceutical Industry Competitive Intelligence
#2
Unraveling Retrograde Signaling Pathways
Article #2: Word Cloud by NT
Article Title (Live Link )All Time Views Categories of Research #3Genomics of Bacterial and Archaeal Viruses ~69 Biological Networks, Gene Regulation and Evolution , Computational Biology/Systems and Bioinformatics , Disease Biology, Small Molecules in Development of Therapeutic Drugs , Genome Biology , Infectious Disease & New Antibiotic Targets , International Global Work in Pharmaceutical , Molecular Genetics & Pharmaceutical , Pharmaceutical Industry Competitive Intelligence , Population Health Management, Genetics & Pharmaceutical , Scientist: Career considerations , Technology Transfer: Biotech and Pharmaceutical
#3
Genomics of Bacterial and Archaeal Viruses
Article #3: Word Cloud by NT
Article Title (Live Link )All Time Views Categories of Research #4Genetics and Male Endocrinology ~103 Biological Networks, Gene Regulation and Evolution , Genome Biology , Genomic Testing: Methodology for Diagnosis , Molecular Genetics & Pharmaceutical , Personalized and Precision Medicine & Genomic Research , Population Health Management, Genetics & Pharmaceutical , Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics
#4
Genetics and Male Endocrinology
Article #4: Word Cloud by NT
#5
Genomics and Evolution
Article #5: Word Cloud by DM
Article Title (Live Link )All Time Views Categories of Research #6Directions for Genomics in Personalized Medicine 668 Biological Networks, Gene Regulation and Evolution , CANCER BIOLOGY & Innovations in Cancer Therapy , Cell Biology, Signaling & Cell Circuits , Chemical Biology and its relations to Metabolic Disease , Genome Biology , International Global Work in Pharmaceutical , Metabolomics , Molecular Genetics & Pharmaceutical , Personalized and Precision Medicine & Genomic Research , Pharmacogenomics
#6
Directions for Genomics in Personalized Medicine
Article #6: Word Cloud by DM
Article Title (Live Link )All Time Views Categories of Research #7FDA Warning for the Leader of Consumer Market for Personal DNA Sequencing: Part 4 ~353 Biomarkers & Medical Diagnostics , Cardiovascular Pharmacogenomics , Chemical Genetics , Computational Biology/Systems and Bioinformatics , Genome Biology , Genomic Testing: Methodology for Diagnosis , Medical and Population Genetics , Metabolomics , Molecular Genetics & Pharmaceutical , Personalized and Precision Medicine & Genomic Research , Pharmaceutical R&D Investment , Pharmacogenomics , Population Health Management, Genetics & Pharmaceutical , Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics , Stem Cells for Regenerative Medicine , Technology Transfer: Biotech and Pharmaceutical
#7
FDA Warning for the Leader of Consumer Market for Personal DNA Sequencing: Part 4
Article #7: Word Cloud by DM
Article Title (Live Link )All Time Views Categories of Research #8Sunitinib brings Adult Acute Lymphoblastic Leukemia (ALL) to Remission – RNA Sequencing – FLT3 Receptor Blockade 983 Bio Instrumentation in Experimental Life Sciences Research , Biological Networks, Gene Regulation and Evolution , Bone Disease and Musculoskeletal Disease , CANCER BIOLOGY & Innovations in Cancer Therapy , Cell Biology, Signaling & Cell Circuits , Chemical Biology and its relations to Metabolic Disease , Chemical Genetics , Computational Biology/Systems and Bioinformatics , Disease Biology, Small Molecules in Development of Therapeutic Drugs , Genome Biology , Health Economics and Outcomes Research , Interviews with Scientific Leaders , Medical and Population Genetics , Nephrology , Nephrology & Regenerative medicine , Personalized and Precision Medicine & Genomic Research , Pharmaceutical Analytics , Pharmaceutical Industry Competitive Intelligence , Pharmaceutical R&D Investment , Population Health Management, Genetics & Pharmaceutical
#8
Sunitinib brings Adult Acute Lymphoblastic Leukemia (ALL) to Remission – RNA Sequencing – FLT3 Receptor Blockade
Article #8: Word Cloud by DM
Article Title (Live Link )All Time Views Categories of Research #9Advances in Separations Technology for the “OMICs” and Clarification of Therapeutic Targets ~267 Alzheimer’s Disease , Bio Instrumentation in Experimental Life Sciences Research , Biological Networks, Gene Regulation and Evolution , Biomarkers & Medical Diagnostics , CANCER BIOLOGY & Innovations in Cancer Therapy , Cell Biology, Signaling & Cell Circuits , Chemical Biology and its relations to Metabolic Disease , Computational Biology/Systems and Bioinformatics , Disease Biology, Small Molecules in Development of Therapeutic Drugs , Genome Biology , Imaging-based Cancer Patient Management , International Global Work in Pharmaceutical , Metabolomics , Molecular Genetics & Pharmaceutical , Nanotechnology for Drug Delivery , Nutrigenomics , Nutrition , Personalized and Precision Medicine & Genomic Research , Pharmaceutical Industry Competitive Intelligence , Pharmaceutical R&D Investment , Pharmacotherapy and Cell Activity , Population Health Management, Genetics & Pharmaceutical , Population Health Management, Nutrition and Phytochemistry , Proteomics , Technology Transfer: Biotech and Pharmaceutical
#9
Advances in Separations Technology for the “OMICs” and Clarification of Therapeutic Targets
Article #9: Word Cloud by ZD
Article Title (Live Link )All Time Views Categories of Research #10Computational Genomics Center: New Unification of Computational Technologies at Stanford ~141 Biological Networks, Gene Regulation and Evolution , Biomarkers & Medical Diagnostics , Cardiovascular Pharmacogenomics , Chemical Genetics , Computational Biology/Systems and Bioinformatics , Genome Biology , Genomic Testing: Methodology for Diagnosis , Medical and Population Genetics , Metabolomics , Molecular Genetics & Pharmaceutical , Personalized and Precision Medicine & Genomic Research , Population Health Management, Genetics & Pharmaceutical , Proteomics , Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics , Scientist: Career considerations , Statistical Methods for Research Evaluation , Technology Transfer: Biotech and Pharmaceutical
#10
Computational Genomics Center: New Unification of Computational Technologies at Stanford
Article #10: Word Cloud by ZD
Article Title (Live Link )All Time Views Categories of Research #11DNA structure and Oligonucleotides 2,290 Chemical Biology and its relations to Metabolic Disease , Chemical Genetics , Computational Biology/Systems and Bioinformatics , Disease Biology, Small Molecules in Development of Therapeutic Drugs , Genome Biology , Genomic Testing: Methodology for Diagnosis , International Global Work in Pharmaceutical , Metabolomics , Molecular Genetics & Pharmaceutical , Personalized and Precision Medicine & Genomic Research , Pharmaceutical Industry Competitive Intelligence , Pharmacogenomics , Population Health Management, Genetics & Pharmaceutical , Technology Transfer: Biotech and Pharmaceutical
#11
DNA structure and Oligonucleotides
Article #11: Word Cloud by ZD
#12
Drugging the Epigenome
Article #12: Word Cloud by ZD
Article Title (Live Link )All Time Views Categories of Research #13Genome-Wide Detection of Single-Nucleotide and Copy-Number Variation of a Single Human Cell ~73 Bio Instrumentation in Experimental Life Sciences Research , Biological Networks, Gene Regulation and Evolution , CANCER BIOLOGY & Innovations in Cancer Therapy , Cell Biology, Signaling & Cell Circuits , Computational Biology/Systems and Bioinformatics , Genome Biology , Genomic Testing: Methodology for Diagnosis , Health Economics and Outcomes Research , Medical and Population Genetics , Personalized and Precision Medicine & Genomic Research , Population Health Management, Genetics & Pharmaceutical
#13
Genome-Wide Detection of Single-Nucleotide and Copy-Number Variation of a Single Human Cell
Article #13: Word Cloud by ZD
Article Title (Live Link )All Time Views Categories of Research #14Genetic Basis of Complex Human Diseases: Dan Koboldt’s Advice to Next-Generation Sequencing Neophytes ~113 Biological Networks, Gene Regulation and Evolution , Chemical Genetics , Computational Biology/Systems and Bioinformatics , Genome Biology , Genomic Testing: Methodology for Diagnosis , Medical and Population Genetics , Personalized and Precision Medicine & Genomic Research , Population Health Management, Genetics & Pharmaceutical , Proteomics , Statistical Methods for Research Evaluation , Technology Transfer: Biotech and Pharmaceutica l
#14
Genetic Basis of Complex Human Diseases: Dan Koboldt’s Advice to Next-Generation Sequencing Neophytes
Article #14: Word Cloud by DM
Article Title (Live Link )All Time Views Categories of Research #15Personal Tale of JL’s Whole Genome Sequencing ~143 Bio Instrumentation in Experimental Life Sciences Research , Chemical Genetics , Computational Biology/Systems and Bioinformatics , Genome Biology , Genomic Testing: Methodology for Diagnosis , Medical and Population Genetics , Molecular Genetics & Pharmaceutical , Patient Experience: Personal Memories of Invasive Medical Intervantion , Personalized and Precision Medicine & Genomic Research , Population Health Management, Genetics & Pharmaceutical , Technology Transfer: Biotech and Pharmaceutical
#15
Personal Tale of JL’s Whole Genome Sequencing
Article #15: Word Cloud by DM
Article Title (Live Link )All Time Views Categories of Research #16Nobel Laureate Jack Szostak Previews his Plenary Keynote for Drug Discovery Chemistry ~222 Advanced Drug Manufacturing Technology , Biological Networks, Gene Regulation and Evolution , Biomarkers & Medical Diagnostics , BioSimilars , Chemical Biology and its relations to Metabolic Disease , Chemical Genetics , Computational Biology/Systems and Bioinformatics , Disease Biology, Small Molecules in Development of Therapeutic Drugs , Drug Delivery Platform Technology , Genome Biology , Genomic Testing: Methodology for Diagnosis , Interviews with Scientific Leaders , Molecular Genetics & Pharmaceutical , Personalized and Precision Medicine & Genomic Research , Pharmaceutical Industry Competitive Intelligence , Pharmaceutical R&D Investment , Proteomics , Scientist: Career considerations , Systemic Inflammatory Response Related Disorders
#16
Nobel Laureate Jack Szostak Previews his Plenary Keynote for Drug Discovery Chemistry
Article #16: Word Cloud by DM
List of Contributors to Volume One
Larry Bernstein, MD, FCAP, Senior Editor
Introduction 1.1, 1.2, 1.4, 1.5, 2.2, 2.6, 3.1, 3.2, 3.3, 3.6, 4.6, 4.8, 5.8, 5.9, 5.10, 6.1, 6.2, 6.3, 6.5, 6.7, 6.8, 6.9, 6.10, 6.11, 6.12, 6.13, 6.14, 6.16, 6.17, 8.5, 8.6, 9.6, 10.4, 10.5, 10.6, 10.7, 11.1, 11.7, 11.10, 11.11, 12.2, 12.3, 12.4, 12.6, 12.8, 13.8, 13.9, 14.3, 14.4, 14.5, 14.6, 14.7, 14.8, 14.9, 15.5, 15.8, 15.9, 15.9.4, 15.11, 16.1, 16.2, 16.3, 16.4, 16.5, 17.2, 18.1, 18.2, 18.5, 18.6, 20.2, 20.3, 20.4, 20.5, 20.6, Introduction-21, Summary-21, Volume Summary, Epilogue
Stephen J. Williams, PhD, Editor
2.3, 2.7, 6.15, 7.6, 8.8, 11.8, 12.5, 12.7, 15.3, 20.7, Introduction-21
Aviva Lev-Ari, PhD, RN, Editor-in-Chief, BioMed e-Books Series
1.6, 2.1, 2.5, 3.4, 3.5, 3.7, 3.8, 4.1, 4.4, 4.5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 6.18, 7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 8.2, 8.3, 8.7, 8.9, 9.1, 9.2, 9.3, 9.4, 9.5, 9.8, 10.1, 10.2, 10.3, 10.8, 11.2, 11.3, 11.4, 11.5, 11.9, 12.1, 13.5 13.7, 15.1, 15.2, 15.4, 15.6, 15.7, 15.9.1, 15.9.2, 15.9.3, 15.9.5, 15.10, 17.1, 18.3, 18.4, 19.4, 19.5, 20.1, 20.8, 21.1.1, 21.1.2, 21.1.3, 21.1.4, 21.2.1, 21.2.2, 21.2.3, 21.2.4, 21.3.1, 21.3.2, 21.4.2
Sudipta Saha, PhD 1.3, 6.6, 11.6, 13.2, 13.3, 13.4, 19.1, 19.2, 19.6, 19.7, 19.8, 19.9, 19.10
Ritu Saxena, PhD 4.2, 6.4, 9.7, 13.6, 14.1, 17.3, 17.4, 17.5, 19.3
Tilda Barlyia, PhD 8.4, 13.1, 14.2
Anamika Sarkar, PhD 4.3
Marcus W Feldman, PhD , Professor of Computational Biology , Stanford University , Department of Biology
2.4
Demet Sag, PhD
4.7, 4.9, 4.10
electronic Table of Contents
Chapter 1
1.1 Advances in the Understanding of the Human Genome The Initiation and Growth of Molecular Biology and Genomics – Part I
1.2 CRACKING THE CODE OF HUMAN LIFE: Milestones along the Way – Part IIA
1.3 DNA – The Next-Generation Storage Media for Digital Information
1.4 CRACKING THE CODE OF HUMAN LIFE: Recent Advances in Genomic Analysis and Disease – Part IIC
1.5 Advances in Separations Technology for the “OMICs” and Clarification of Therapeutic Targets
1.6 Genomic Analysis: FLUIDIGM Technology in the Life Science and Agricultural Biotechnology
Chapter 2
2.1 2013 Genomics: The Era Beyond the Sequencing of the Human Genome: Francis Collins, Craig Venter, Eric Lander, et al.
2.2 DNA structure and Oligonucleotides
2.3 Genome-Wide Detection of Single-Nucleotide and Copy-Number Variation of a Single Human Cell
2.4 Genomics and Evolution
2.5 Protein-folding Simulation: Stanford’s Framework for Testing and Predicting Evolutionary Outcomes in Living Organisms – Work by Marcus Feldman
2.6 The Binding of Oligonucleotides in DNA and 3-D Lattice Structures
2.7 Finding the Genetic Links in Common Disease: Caveats of Whole Genome Sequencing Studies
Chapter 3
3.1 Big Data in Genomic Medicine
3.2 CRACKING THE CODE OF HUMAN LIFE: The Birth of Bioinformatics & Computational Genomics – Part IIB
3.3 Expanding the Genetic Alphabet and linking the Genome to the Metabolome
3.4 Metabolite Identification Combining Genetic and Metabolic Information: Genetic Association Links Unknown Metabolites to Functionally Related Genes
3.5 MIT Scientists on Proteomics: All the Proteins in the Mitochondrial Matrix identified
3.6 Identification of Biomarkers that are Related to the Actin Cytoskeleton
3.7 Genetic basis of Complex Human Diseases: Dan Koboldt’s Advice to Next-Generation Sequencing Neophytes
3.8 MIT Team Researches Regulatory Motifs and Gene Expression of Erythroleukemia (K562) and Liver Carcinoma (HepG2) Cell Lines
Chapter 4
4.1 ENCODE Findings as Consortium
4.2 ENCODE: The Key to Unlocking the Secrets of Complex Genetic Diseases
4.3 Reveals from ENCODE Project will Invite High Synergistic Collaborations to Discover Specific Targets
4.4 Human Variome Project: encyclopedic catalog of sequence variants indexed to the human genome sequence
4.5 Human Genome Project – 10th Anniversary: Interview with Kevin Davies, PhD – The $1000 Genome
4.6 Quantum Biology And Computational Medicine
4.7 The Underappreciated EpiGenome
4.8 Unraveling Retrograde Signaling Pathways
4.9 “The SILENCE of the Lambs” Introducing The Power of Uncoded RNA
4.10 DNA: One man’s trash is another man’s treasure, but there is no JUNK after all
Chapter 5
5.1 Paradigm Shift in Human Genomics – Predictive Biomarkers and Personalized Medicine – Part 1
5.2 Computational Genomics Center: New Unification of Computational Technologies at Stanford
5.3 Personalized Medicine: An Institute Profile – Coriell Institute for Medical Research: Part 3
5.4 Cancer Genomics – Leading the Way by Cancer Genomics Program at UC Santa Cruz
5.5 Genome and Genetics: Resources @Stanford, @MIT, @NIH’s NCBCS
5.6 NGS Market: Trends and Development for Genotype-Phenotype Associations Research
5.7 Speeding Up Genome Analysis: MIT Algorithms for Direct Computation on Compressed Genomic Datasets
5.8 Modeling Targeted Therapy
5.9 Transphosphorylation of E-coli Proteins and Kinase Specificity
5.10 Genomics of Bacterial and Archaeal Viruses
Chapter 6
6.1 Directions for Genomics in Personalized Medicine
6.2 Ubiquinin-Proteosome pathway, Autophagy, the Mitochondrion, Proteolysis and Cell Apoptosis: Part III
6.3 Mitochondrial Damage and Repair under Oxidative Stress
6.4 Mitochondria: More than just the “Powerhouse of the Cell”
6.5 Mechanism of Variegation in Immutans
6.6 Impact of Evolutionary Selection on Functional Regions: The imprint of Evolutionary Selection on ENCODE Regulatory Elements is Manifested between Species and within Human Populations
6.7 Cardiac Ca2+ Signaling: Transcriptional Control
6.8 Unraveling Retrograde Signaling Pathways
6.9 Reprogramming Cell Fate
6.10 How Genes Function
6.11 TALENs and ZFNs
6.12 Zebrafish—Susceptible to Cancer
6.13 RNA Virus Genome as Bacterial Chromosome
6.14 Cloning the Vaccinia Virus Genome as a Bacterial Artificial Chromosome
6.15 Telling NO to Cardiac Risk- DDAH Says NO to ADMA(1); The DDAH/ADMA/NOS Pathway(2)
6.16 Transphosphorylation of E-coli proteins and kinase specificity
6.17 Genomics of Bacterial and Archaeal Viruses
6.18 Diagnosing Diseases & Gene Therapy: Precision Genome Editing and Cost-effective microRNA Profiling
Chapter 7
7.1 Harnessing Personalized Medicine for Cancer Management, Prospects of Prevention and Cure: Opinions of Cancer Scientific Leaders @ http://pharmaceuticalintelligence.com
7.2 Consumer Market for Personal DNA Sequencing: Part 4
7.3 GSK for Personalized Medicine using Cancer Drugs Needs Alacris Systems Biology Model to Determine the In Silico Effect of the Inhibitor in its “Virtual Clinical Trial”
7.4 Drugging the Epigenome
7.5 Nation’s Biobanks: Academic institutions, Research institutes and Hospitals – vary by Collections Size, Types of Specimens and Applications: Regulations are Needed
7.6 Personalized Medicine: Clinical Aspiration of Microarrays
Chapter 8
8.1 Personalized Medicine as Key Area for Future Pharmaceutical Growth
8.2 Inaugural Genomics in Medicine – The Conference Program, 2/11-12/2013, San Francisco, CA
8.3 The Way With Personalized Medicine: Reporters’ Voice at the 8th Annual Personalized Medicine Conference, 11/28-29, 2012, Harvard Medical School, Boston, MA
8.4 Nanotechnology, Personalized Medicine and DNA Sequencing
8.5 Targeted Nucleases
8.6 Transcript Dynamics of Proinflammatory Genes
8.7 Helping Physicians identify Gene-Drug Interactions for Treatment Decisions: New ‘CLIPMERGE’ program – Personalized Medicine @ The Mount Sinai Medical Center
8.8 Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing[1]
8.9 Diagnosing Diseases & Gene Therapy: Precision Genome Editing and Cost-effective microRNA Profiling
Chapter 9
9.1 Personal Tale of JL’s Whole Genome Sequencing
9.2 Inspiration From Dr. Maureen Cronin’s Achievements in Applying Genomic Sequencing to Cancer Diagnostics
9.3 Inform Genomics Developing SNP Test to Predict Side Effects, Help MDs Choose among Chemo Regimens
9.4 SNAP: Predict Effect of Non-synonymous Polymorphisms: How Well Genome Interpretation Tools could Translate to the Clinic
9.5 LEADERS in Genome Sequencing of Genetic Mutations for Therapeutic Drug Selection in Cancer Personalized Treatment: Part 2
9.6 The Initiation and Growth of Molecular Biology and Genomics – Part I
9.7 Personalized Medicine-based Cure for Cancer Might Not Be Far Away
9.8 Personalized Medicine: Cancer Cell Biology and Minimally Invasive Surgery (MIS)
Chapter 10
10.1 Pfizer’s Kidney Cancer Drug Sutent Effectively caused REMISSION to Adult Acute Lymphoblastic Leukemia (ALL)
10.2 Imatinib (Gleevec) May Help Treat Aggressive Lymphoma: Chronic Lymphocytic Leukemia (CLL)
10.3 Winning Over Cancer Progression: New Oncology Drugs to Suppress Passengers Mutations vs. Driver Mutations
10.4 Treatment for Metastatic HER2 Breast Cancer
10.5 Personalized Medicine in NSCLC
10.6 Gene Sequencing – to the Bedside
10.7 DNA Sequencing Technology
10.8 Nobel Laureate Jack Szostak Previews his Plenary Keynote for Drug Discovery Chemistry
Chapter 11
11.1 mRNA Interference with Cancer Expression
11.2 Angiogenic Disease Research Utilizing microRNA Technology: UCSD and Regulus Therapeutics
11.3 Sunitinib brings Adult acute lymphoblastic leukemia (ALL) to Remission – RNA Sequencing – FLT3 Receptor Blockade
11.4 A microRNA Prognostic Marker Identified in Acute Leukemia
11.5 MIT Team: Microfluidic-based approach – A Vectorless delivery of Functional siRNAs into Cells.
11.6 Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4
11.7 When Clinical Application of miRNAs?
11.8 How mobile elements in “Junk” DNA promote cancer. Part 1: Transposon-mediated tumorigenesis,
11.9 Potential Drug Target: Glycolysis Regulation – Oxidative Stress-responsive microRNA-320
11.10 MicroRNA Molecule May Serve as Biomarker
11.11 What about Circular RNAs?
Chapter 12
12.1 The “Cancer Establishments” Examined by James Watson, Co-discoverer of DNA w/Crick, 4/1953
12.2 Otto Warburg, A Giant of Modern Cellular Biology
12.3 Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?
12.4 Hypothesis – Following on James Watson
12.5 AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
12.6 AKT signaling variable effects
12.7 Rewriting the Mathematics of Tumor Growth; Teams Use Math Models to Sort Drivers from Passengers
12.8 Phosphatidyl-5-Inositol signaling by Pin1
Chapter 13
13.1 Nanotech Therapy for Breast Cancer
13.2 BRCA1 a tumour suppressor in breast and ovarian cancer – functions in transcription, ubiquitination and DNA repair
13.3 Exome sequencing of serous endometrial tumors shows recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
13.4 Recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes in serous endometrial tumors
13.5 Prostate Cancer: Androgen-driven “Pathomechanism” in Early onset Forms of the Disease
13.6 In focus: Melanoma Genetics
13.7 Head and Neck Cancer Studies Suggest Alternative Markers More Prognostically Useful than HPV DNA Testing
13.8 Breast Cancer and Mitochondrial Mutations
13.9 Long noncoding RNA network regulates PTEN transcription
Chapter 14
14.1 HBV and HCV-associated Liver Cancer: Important Insights from the Genome
14.2 Nanotechnology and HIV/AIDS treatment
14.3 IRF-1 Deficiency Skews the Differentiation of Dendritic Cells
14.4 Sepsis, Multi-organ Dysfunction Syndrome, and Septic Shock: A Conundrum of Signaling Pathways Cascading Out of Control
14.5 Five Malaria Genomes Sequenced
14.6 Rheumatoid Arthritis Risk
14.7 Approach to Controlling Pathogenic Inflammation in Arthritis
14.8 RNA Virus Genome as Bacterial Chromosome
14.9 Cloning the Vaccinia Virus Genome as a Bacterial Artificial Chromosome
Chapter 15
15.1 Personalized Cardiovascular Genetic Medicine at Partners HealthCare and Harvard Medical School
15.2 Congestive Heart Failure & Personalized Medicine: Two-gene Test predicts response to Beta Blocker Bucindolol
15.3 DDAH Says NO to ADMA(1); The DDAH/ADMA/NOS Pathway(2)
15.4 Peroxisome Proliferator-Activated Receptor (PPAR-gamma) Receptors Activation: PPARγ Transrepression for Angiogenesis in Cardiovascular Disease and PPARγ Transactivation for Treatment of Diabetes
15.5 BARI 2D Trial Outcomes
15.6 Gene Therapy Into Healthy Heart Muscle: Reprogramming Scar Tissue In Damaged Hearts
15.7 Obstructive coronary artery disease diagnosed by RNA levels of 23 genes – CardioDx, a Pioneer in the Field of Cardiovascular Genomic Diagnostics
15.8 Ca2+ signaling: transcriptional control
15.9 Lp(a) Gene Variant Association
15.9.1 Two Mutations, in the PCSK9 Gene: Eliminates a Protein involved in Controlling LDL Cholesterol
15.9.2. Genomics & Genetics of Cardiovascular Disease Diagnoses: A Literature Survey of AHA’s Circulation Cardiovascular Genetics, 3/2010 – 3/2013
15.9.3 Synthetic Biology: On Advanced Genome Interpretation for Gene Variants and Pathways: What is the Genetic Base of Atherosclerosis and Loss of Arterial Elasticity with Aging
15.9.4 The Implications of a Newly Discovered CYP2J2 Gene Polymorphism Associated with Coronary Vascular Disease in the Uygur Chinese Population
15.9.5 Gene, Meis1, Regulates the Heart’s Ability to Regenerate after Injuries.
15.10 Genetics of Conduction Disease: Atrioventricular (AV) Conduction Disease (block): Gene Mutations – Transcription, Excitability, and Energy Homeostasis
15.11 How Might Sleep Apnea Lead to Serious Health Concerns like Cardiac and Cancers?
Chapter 16
16.1 Can Resolvins Suppress Acute Lung Injury?
16.2 Lipoxin A4 Regulates Natural Killer Cell in Asthma
16.3 Biological Therapeutics for Asthma
16.4 Genomics of Bronchial Epithelial Dysplasia
16.5 Progression in Bronchial Dysplasia
Chapter 17
17.1 Breakthrough Digestive Disorders Research: Conditions Affecting the Gastrointestinal Tract.
17.2 Liver Endoplasmic Reticulum Stress and Hepatosteatosis
17.3 Biomarkers-identified-for-recurrence-in-hbv-related-hcc-patients-post-surgery
17.4 Usp9x: Promising Therapeutic Target for Pancreatic Cancer
17.5 Battle of Steve Jobs and Ralph Steinman with Pancreatic cancer: How We Lost
Chapter 18
18.1 Ubiquitin Pathway Involved in Neurodegenerative Disease
18.2 Genomic Promise for Neurodegenerative Diseases, Dementias, Autism Spectrum, Schizophrenia, and Serious Depression
18.3 Neuroprotective Therapies: Pharmacogenomics vs Psychotropic Drugs and Cholinesterase Inhibitors
18.4 Ustekinumab New Drug Therapy for Cognitive Decline Resulting from Neuroinflammatory Cytokine Signaling and Alzheimer’s Disease
18.5 Cell Transplantation in Brain Repair
18.6 Alzheimer’s Disease Conundrum – Are We Near the End of the Puzzle?
Chapter 19
19.1 Genetics and Male Endocrinology
19.2 Genomic Endocrinology and its Future
19.3 Commentary on Dr. Baker’s post “Junk DNA Codes for Valuable miRNAs: Non-coding DNA Controls Diabetes”
19.4 Therapeutic Targets for Diabetes and Related Metabolic Disorders
19.5 Secondary Hypertension caused by Aldosterone-producing Adenomas caused by Somatic Mutations in ATP1A1 and ATP2B3 (adrenal cortical; medullary or Organ of Zuckerkandl is pheochromocytoma)
19.6 Personal Recombination Map from Individual’s Sperm Cell and its Importance
19.7 Gene Trap Mutagenesis in Reproductive Research
19.8 Pregnancy with a Leptin-Receptor Mutation
19.9 Whole-genome Sequencing in Probing the Meiotic Recombination and Aneuploidy of Single Sperm Cells
19.10 Reproductive Genetic Testing
Chapter 20
20.1 Genomics & Ethics: DNA Fragments are Products of Nature or Patentable Genes?
20.2 Understanding the Role of Personalized Medicine
20.3 Attitudes of Patients about Personalized Medicine
20.4 Genome Sequencing of the Healthy
20.5 Genomics in Medicine – Tomorrow’s Promise
20.6 The Promise of Personalized Medicine
20.7 Ethical Concerns in Personalized Medicine: BRCA1/2 Testing in Minors and Communication of Breast Cancer Risk
20.8 Genomic Liberty of Ownership, Genome Medicine and Patenting the Human Genome
Chapter 21
Recent Advances in Gene Editing Technology Adds New Therapeutic Potential for the Genomic Era: Medical Interpretation of the Genomics Frontier – CRISPR – Cas9
Introduction
21.1 Introducing CRISPR/Cas9 Gene Editing Technology – Works by Jennifer A. Doudna
21.1.1 Ribozymes and RNA Machines – Work of Jennifer A. Doudna
21.1.2 Evaluate your Cas9 gene editing vectors: CRISPR/Cas Mediated Genome Engineering – Is your CRISPR gRNA optimized for your cell lines?
21.1.3 2:15 – 2:45, 6/13/2014, Jennifer Doudna “The biology of CRISPRs: from genome defense to genetic engineering”
21.1.4 Prediction of the Winner RNA Technology, the FRONTIER of SCIENCE on RNA Biology, Cancer and Therapeutics & The Start Up Landscape in BostonGene Editing – New Technology The Missing link for Gene Therapy?
21.2 CRISPR in Other Labs
21.2.1 CRISPR @MIT – Genome Surgery
21.2.2 The CRISPR-Cas9 System: A Powerful Tool for Genome Engineering and Regulation
Yongmin Yan and Department of Gastroenterology, Hepatology & Nutrition, University of Texas M.D. Anderson Cancer, Houston, USADaoyan Wei*
21.2.3 New Frontiers in Gene Editing: Transitioning From the Lab to the Clinic, February 19-20, 2015 | The InterContinental San Francisco | San Francisco, CA
21.2.4 Gene Therapy and the Genetic Study of Disease: @Berkeley and @UCSF – New DNA-editing technology spawns bold UC initiative as Crispr Goes Global
21.2.5 CRISPR & MAGE @ George Church’s Lab @ Harvard
21.3 Patents Awarded and Pending for CRISPR
21.3.1 Litigation on the Way: Broad Institute Gets Patent on Revolutionary Gene-Editing Method
21.3.2 The Patents for CRISPR, the DNA editing technology as the Biggest Biotech Discovery of the Century
2.4 CRISPR/Cas9 Applications
21.4.1 Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells using a bacterial CRISPR/Cas
21.4.2 CRISPR: Applications for Autoimmune Diseases @UCSF
21.4.3 In vivo validated mRNAs
21.4.6 Level of Comfort with Making Changes to the DNA of an Organism
21.4.7 Who will be the the First to IPO: Novartis bought in to Intellia (UC, Berkeley) as well as Caribou (UC, Berkeley) vs Editas (MIT)??
21.4.8 CRISPR/Cas9 Finds Its Way As an Important Tool For Drug Discovery & Development
Summary
Like this: Like Loading...
Leave a Reply