Lp(a) Gene Variant Association

March 6, 2013 by larryhbern

Lp(a) Gene Variant Association

Reporter: Larry H Bernstein, MD, FCAP

Lp(a) Gene Variant Associated With Aortic Stenosis

Reported by Lisa Nainggolan Feb 06, 2013; GThanassoulis et al. NEJM http://www.theheart.org/article/1503525.do

People carrying this single nucleotide polymorphism (SNP) had a doubling of the risk of valve calcification on computer tomography (CT) compared with those without the variation. The same SNP has previously been identified as a risk factor for increased Lp(a) levels and coronary artery disease (CAD). Findings Could Reawaken Interest in Therapies Targeting Lp(a)

Genetic Study Identifies Strong Links To Aortic Valve Disease (forbes.com)
Researchers Find Gene Variant Linked To Aortic Valve Disease (medicalnewstoday.com)
MGH’s Largest-ever Genetic Study of Five Psychiatric Disorders: Variation in SNPs in Two Genes involved in Calcium-Channel Signaling (pharmaceuticalintelligence.com)
Link Between Most Common Form Of Heart Valve Disease And Unusual Cholesterol (medicalnewstoday.com)

A Single Nucleotide Polymorphism is a change of a nucleotide at a single base-pair location on DNA. Created using Inkscape v0.45.1. (Photo credit: Wikipedia)

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