Lp(a) Gene Variant Association
Reporter: Larry H Bernstein, MD, FCAP
Lp(a) Gene Variant Associated With Aortic Stenosis
Reported by Lisa Nainggolan Feb 06, 2013; GThanassoulis et al. NEJM http://www.theheart.org/article/1503525.do
People carrying this single nucleotide polymorphism (SNP) had a doubling of the risk of valve calcification on computer tomography (CT) compared with those without the variation. The same SNP has previously been identified as a risk factor for increased Lp(a) levels and coronary artery disease (CAD). Findings Could Reawaken Interest in Therapies Targeting Lp(a)
Related articles
- Genetic Study Identifies Strong Links To Aortic Valve Disease (forbes.com)
- Researchers Find Gene Variant Linked To Aortic Valve Disease (medicalnewstoday.com)
- MGH’s Largest-ever Genetic Study of Five Psychiatric Disorders: Variation in SNPs in Two Genes involved in Calcium-Channel Signaling (pharmaceuticalintelligence.com)
- Link Between Most Common Form Of Heart Valve Disease And Unusual Cholesterol (medicalnewstoday.com)
A Single Nucleotide Polymorphism is a change of a nucleotide at a single base-pair location on DNA. Created using Inkscape v0.45.1. (Photo credit: Wikipedia)
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