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microRNA Biomarker

Reporter: Larry H Bernstein, MD, FCAP

MicroRNA Molecule May Serve as Biomarker

miRNA molecule called miR-7 decreased in highly metastatic cancer stem-like cells.

February 18, 2013

Researchers have identified two molecules that could potentially serve as biomarkers in

• predicting brain metastases in patients with breast cancer.

MicroRNAs are involved in

• tumor initiation and
• progression, and
• may play a role in metastasis, particularly in relation to
• cancer stem-like cells.

miR-7 is a metastasis

• suppressor in cancer stem-like cells, and when they
• increased expression of miR-7 in cancer stem-like cells from
  • metastatic human breast cancer cell lines,
  • it suppressed their metastatic properties.

miR-7 suppressed ………….expression of KLF4.
However, miR-7 significantly suppressed the ability of cancer stem-like cells to metastasize to the brain but not the bone.

http://CancerResearch.com/miRNA-decreased-in-highly-metastatic-cancer-stem-like-cells/Watabe/

A gram illustrating the disctinction between cancer stem cell targeted (above) and conventional (below) cancer therapies (Photo credit: Wikipedia)

Related articles

• The Era of MicroRNAs (ajkdblog.org)
• MicroRNA Molecule May Serve As Biomarker, Target For Brain Metastases In Breast Cancer Patients (medicalnewstoday.com)
• In Ovarian Cancer MiR-506 Works By Blocking Epithelial-To-Mesenchymal Cell Transition (medicalnewstoday.com)
• Insights on the Functional Impact of MicroRNAs Present in Autism-Associated Copy Number Variants (plosone.org)
• MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients (sciencedaily.com)
• Emerging Pharmaceutical Technologies – Stem Cells to Play a Significant Role in the Pharmaceutical Industry of the Future (prweb.com)
• MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients (eurekalert.org)
• Using MicroRNA To Identify Triple-Negative Breast Cancer Subtypes (medicalnewstoday.com)
• Transcriptome Profiling of microRNA by Next-Gen Deep Sequencing Reveals Known and Novel miRNA Species in the Lipid Fraction of Human Breast Milk (plosone.org)
• Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients (plosone.org)
• ERCC1 Isoform Expression and DNA Repair in Non–Small-Cell Lung Cancer

 

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Posted in Biological Networks, Gene Regulation and Evolution, Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Genome Biology, Genomic Testing: Methodology for Diagnosis, International Global Work in Pharmaceutical, Molecular Genetics & Pharmaceutical, Personalized and Precision Medicine & Genomic Research, Pharmacogenomics, Scientist: Career considerations, Technology Transfer: Biotech and Pharmaceutical | Tagged biomarker, Breast, breast cancer, Cancer - General, Cell Biology, Cell culture, metastasis, MicroRNA, RNA, Stem cell | 2 Comments

2 Responses

1. on March 4, 2013 at 10:16 AM | Reply When Clinical Application of miRNAs? | Pharmaceutical Intelligence

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2. on March 4, 2013 at 10:46 AM | Reply What about Circular RNAs? | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
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