microRNA Biomarker
Reporter: Larry H Bernstein, MD, FCAP
MicroRNA Molecule May Serve as Biomarker
February 18, 2013
Researchers have identified two molecules that could potentially serve as biomarkers in
- predicting brain metastases in patients with breast cancer.
MicroRNAs are involved in
- tumor initiation and
- progression, and
- may play a role in metastasis, particularly in relation to
- cancer stem-like cells.
miR-7 is a metastasis
- suppressor in cancer stem-like cells, and when they
- increased expression of miR-7 in cancer stem-like cells from
- metastatic human breast cancer cell lines,
- it suppressed their metastatic properties.
miR-7 suppressed ………….expression of KLF4.
However, miR-7 significantly suppressed the ability of cancer stem-like cells to metastasize to the brain but not the bone.
A gram illustrating the disctinction between cancer stem cell targeted (above) and conventional (below) cancer therapies (Photo credit: Wikipedia)
Related articles
- The Era of MicroRNAs (ajkdblog.org)
- MicroRNA Molecule May Serve As Biomarker, Target For Brain Metastases In Breast Cancer Patients (medicalnewstoday.com)
- In Ovarian Cancer MiR-506 Works By Blocking Epithelial-To-Mesenchymal Cell Transition (medicalnewstoday.com)
- Insights on the Functional Impact of MicroRNAs Present in Autism-Associated Copy Number Variants (plosone.org)
- MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients (sciencedaily.com)
- Emerging Pharmaceutical Technologies – Stem Cells to Play a Significant Role in the Pharmaceutical Industry of the Future (prweb.com)
- MicroRNA molecule may serve as biomarker, target for brain metastases in breast cancer patients (eurekalert.org)
- Using MicroRNA To Identify Triple-Negative Breast Cancer Subtypes (medicalnewstoday.com)
- Transcriptome Profiling of microRNA by Next-Gen Deep Sequencing Reveals Known and Novel miRNA Species in the Lipid Fraction of Human Breast Milk (plosone.org)
- Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients (plosone.org)
- ERCC1 Isoform Expression and DNA Repair in Non–Small-Cell Lung Cancer
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