Malaria Genomes
Curator: Larry H Bernstein, MD, FCAP
Five Malaria Genomes Sequenced
Zimmerman et al.
Whole Genome Sequencing of Field Isolates Provides Robust Characterization of Genetic Diversity in Plasmodium vivax.
Scientists have sequenced the entire genomes of five Plasmodium vivax strains taken from the blood of patients on different continents, providing
- a wealth of new data to help in the future mapping of malarial parasite traits such as
- drug resistance, and
determine how different strains are geographically distributed.
The work, by researchers at Case Western Reserve University and the Cleveland Clinic Lerner Research Institute, has
- identified over 80,000 SNPs that can form the basis of association studies and
- population surveys to study the diversity of P. vivax in a single region.
Malaria. (Photo credit: maestro garabito/escuela potosina)
Malaria distribution map. Most countries with a high distribution of malaria also have a high distribution of parasitic worm infections. (Photo credit: Wikipedia)
English: This thin film Giemsa stained micrograph reveals a mature Plasmodium vivax trophozoite. P. vivax trophozoites show amoeboid cytoplasm, large chromatin dots, and fine, yellowish-brown pigment. RBCs are enlarged 1 1/2 – 2X, and may be distorted. If visible, Schüffner’s dots may appear finer than those seen in P. vivax. (Photo credit: Wikipedia)
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