Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Posts Tagged ‘Antibodies’

Affymetrix to Stick With Thermo Fisher’s Takeover Proposal

Posted in Computational Biology/Systems and Bioinformatics, Exosomes, Gene Regulation and Evolution, Genetics & Innovations in Treatment, Genetics & Pharmaceutical, Genome Biology, Genomic Testing: Methodology for Diagnosis, Investment in Technological Breakthrough, Mutagenesis, tagged AgBio, and proteins, Antibodies, clinical markets, cytogenetics, ELISAs, gene expression, GeneChip, genetic analysis, genotyping, life sciences research, microarray technology, multiplex RNA, multiplexed and parallel analysis of biological systems at the cell, protein and genetic level, protein assay, reproductive health, single-cell assays, single-cell biology on January 12, 2016| 2 Comments »

UPDATED on 3/28/2016

Affymetrix to Stick With Thermo Fisher’s Takeover Proposal

By MICHAEL J. de la MERCED MARCH 28, 2016

SAN FRANCISCO — What briefly appeared to be a potential bidding war for Affymetrix, a genetics analysis technology maker, fizzled out on Monday after the company chose to stick with a takeover bid from Thermo Fisher Scientific over a higher bid from a Chinese-backed suitor.

In a statement, Affymetrix reiterated its support for the $14-a-share offer from Thermo Fisher that it accepted in January.

http://www.nytimes.com/2016/03/29/business/dealbook/affymetrix-to-stick-with-thermo-fishers-takeover-proposal.html?&moduleDetail=section-news-3&action=click&contentCollection=DealBook&region=Footer&module=MoreInSection&version=WhatsNext&contentID=WhatsNext&pgtype=article 

UPDATED on 3/23/2016

Affymetrix Postpones Stockholder Meeting as Origin Ups Acquisition Offer; Board Backs Thermo Bid

Mar 23, 2016

In a statement, Affy said that based on the terms of the new offer, it determined that failure to engage with Origin on its bid could reasonably be expected to be “inconsistent with the board’s duties under Delaware law.”

However, Affy said that its board continues to recommend that its stockholders vote in favor of the adoption of the merger agreement with Thermo Fisher, explaining that it “has not determined that the Origin proposal is in fact a ‘superior proposal’ for purposes of the merger agreement with Thermo Fisher and is not making an adverse recommendation change.

“We fully expect that the Affymetrix board of directors will promptly conclude that our transaction remains the only bona fide alternative for Affymetrix stockholders and, as contemplated by the terms of our merger agreement, will definitively recommend against the Origin Technologies proposal and in favor of the Thermo Fisher transaction prior to the upcoming stockholder meeting,” Thermo Fisher President and CEO Marc Casper said in a statement this morning.

“Origin Technologies has still not addressed the fundamental flaws of its proposal, which has remained from its first announcement highly contingent, uncertain, and insufficient,” he added.

SOURCE

a GenomeWeb staff reporter

https://www.genomeweb.com/microarrays-multiplexing/affymetrix-postpones-stockholder-meeting-origin-ups-acquisition-offer-board?utm_source=SilverpopMailing&utm_medium=email&utm_campaign=Daily%20News:%20Affymetrix%20Postpones%20Stockholder%20Meeting%20as%20Origin%20Ups%20Acquisition%20Offer;%20Board%20Backs%20Thermo%20Bid%20-%2003/23/2016%2010:45:00%20AM

UPDATED on 3/21/2016

Former Affymetrix Execs Offer to Buy Company in Alternative to Thermo Fisher Deal

Mar 18, 2016

 

a GenomeWeb staff reporter

NEW YORK (GenomeWeb) – Origin Technologies Corporation, founded by former Affymetrix executives for the purpose of purchasing the company, proposed today to acquire Affy for $16.10 per share in an all-cash transaction valued at approximately $1.5 billion.

The proposal comes about a week before Affy shareholders are scheduled to vote on a different deal, Thermo Fisher Scientific’s proposed acquisition of Affy for approximately $1.3 billion, which the boards of directors of both firms unanimously approved in January.

According to a letter sent by Origin to Affymetrix today, its proposal represents a 75 percent premium to Affymetrix’s unaffected closing share price of $9.21 on the last trading day prior to the announcement of Thermo Fisher’s proposed acquisition.

Fully financed by SummitView Capital, Origin said its all-cash offer represents a 15 percent premium for Affy stockholders relative to the proposed transaction with Thermo, under which stockholders would receive $14.00 per share in cash.

As part of the offer, Origin also pledged to fund payment of the $55 million termination fee that would be due to Thermo under the terms of Thermo and Affy’s January agreement.

Wei Zhou, president of the newly formed Origin, wrote in the letter to Affy today that Origin strongly believes that its offer is superior to Thermo’s based on several criteria.

First, it offers substantially higher value to Affy’s stockholders, he said. Additionally, Origin believes it is in a better position to help Affy achieve its potential as a standalone, global company focused on genomics and proteomics. The deal would also offer an opportunity to acquire new technologies in the complete human genome sequencing space, Zhou wrote.

If the Origin-Affy merger goes through, Origin would have a separate option of combining with another company founded by Zhou in 2009, Centrillion Technology Holdings Corporation.

SOURCE

https://www.genomeweb.com/business-news/former-affymetrix-execs-offer-buy-company-alternative-thermo-fisher-deal

 

Affymetrix: Sales $350 million, Acquisition Price $1.3 billion – Advantages: Cytogenetics, Genotyping and Gene Expression Analysis

Reporter: Aviva Lev-Ari, PhD, RN

Thermo Fisher Scientific Inc.

NYSE: TMO – Jan 12 1:13 PM EST

136.601.72 (1.28%)

Thermo Fisher Scientific to acquire Affymetrix for $1.3 billion

WALTHAM, Mass. – Thermo Fisher Scientific Inc., announced Jan. 8 that it has agreed to acquire Affymetrix Inc. for $14.00 per share in cash, or roughly $1.3 billion. The transaction, approved by the boards of directors of both companies is pending shareholder approval and is expected to close in the second quarter this year.

Santa Clara, Calif.-based Affymetrix was founded in 1992 and is a pioneer in the field of

• microarray technology, launching its
• GeneChip line in 1994. Today, the company serves both the

1. life sciences research and
2. clinical markets

Over the past ten years, the company has broadened its portfolio of tools that enable both

• multiplexed and
• parallel analysis of
• biological systems at the cell, protein and genetic level.

Notable acquisitions for Affymetrix have included genetic tools company ParAllele Bioscience (2005), genetic, protein and cellular analysis provider Panomics (2008), and eBioscience (2012), which included one of the world’s largest selections of

• antibodies,
• ELISAs, and
• proteins

for life science research and diagnostics.

“The acquisition of Affymetrix will strengthen our leadership in biosciences and create new market opportunities for us in genetic analysis,” said Marc N. Casper, president and CEO of Thermo Fisher Scientific. “In biosciences, the company’s antibody portfolio will significantly expand our offering in the fast-growing flow cytometry market, and customers will have greater access to these products through our global scale and commercial reach. In genetic analysis, Affymetrix’s technologies are highly complementary and present new opportunities for us in targeted

• clinical and
• applied markets.”

According to Frank Whitney, president and CEO of Affymetrix, the acquisition will allow the company to continue to build upon the close relationships it has created with customers, while deepening its reach into the biopharma market. “We are excited about the opportunity to combine our portfolios and strengthen our position in high-growth markets such as

• single-cell biology
• reproductive health and
• AgBio

According to information provided by Thermo Fisher, benefits of the acquisition include expanding its offerings of its antibody portfolio via the eBioscience line of products, which also includes

• multiplex RNA,
• protein assay
• single-cell assays
• genetic analysis capabilities via complementary products used in

1. cytogenetics
2. genotyping and
3. gene expression.

Thermo expects Affymetrix will add $0.10 in adjusted earnings per share in the first full year of ownership, while creating $70 million in operational savings by year three. Affymetrix has annual revenues of approximately $350 million and will be integrated within Thermo Fisher’s Life Sciences Solutions business unit.

SOURCE

http://www.thejournalofprecisionmedicine.com/thermo-fisher-scientific-to-acquire-affymetrix-for-1-3-billion/

 

Other related articles published in this Open Access Online Scientific Journal include the following:

 

Gene Editing: The Role of Oligonucleotide Chips

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/07/gene-editing-the-role-of-oligonucleotide-chips/

 

Articles on Immune-Oncology Molecules In Development @pharmaceuticalintelligence.com

Curators: Stephen J Williams, PhD and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/11/articles-on-immune-oncology-molecules-in-development-pharmaceuticalintelligence-com/

 

 

Advertisements

Read Full Post »

Biological Therapeutics for Asthma

Posted in Advanced Drug Manufacturing Technology, Biological Networks, Gene Regulation and Evolution, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Genome Biology, Human Immune System in Health and in Disease, International Global Work in Pharmaceutical, Pharmaceutical Industry Competitive Intelligence, tagged Allergy, Antibodies, Asthma, Biology, Food and Drug Administration, Immunoglobulin E, Immunology, Johns Hopkins School of Medicine, Monoclonal antibodies, Therapy on March 8, 2013| 1 Comment »

Biological Therapeutics for Asthma

Curator: Larry H Bernstein, MD, FCAP

 

Update on Biological Therapeutics for Asthma

Marisha L. Cook, MD, and Bruce S. Bochner, MD
Department of Medicine, Division of Allergy and Clinical Immunology
Johns Hopkins University School of Medicine, Baltimore, MD

BASIC AND CLINICAL TRANSLATIONAL SCIENCE IN ALLERGY, ASTHMA AND IMMUNOLOGY
WAO Journal 2010; 3:188–194
Difficulty in managing severe asthma has encouraged research about its pathobiology and treatment options. Novel biologic therapeutics are being developed for the treatment of asthma and are of potential use for severe refractory asthma, especially where the increased cost of such agents is more likely justified. This review summarizes currently approved (omalizumab) and investigational biologic agents for asthma, such as

• antibodies,
• soluble receptors,
•  other protein-based antagonists,

and highlight recent published data on efficacy and safety of these therapies in humans. As these newer agents with highly targeted pharmacology are tested in asthma,

• we are also poised to learn more about the role of cytokines and other molecules in the pathophysiology of asthma.

Key Words: asthma, biologic therapies, cytokines, monoclonal antibodies

Despite the well-known and fairly consistent efficacy of

drugs such as inhaled corticosteroids, leukotriene modifiers

and
2 agonists for the majority of asthmatics, as many as

10% suffer from severe disease inadequately controlled by

conventional therapy. Severe and sustained symptoms lead to

poor quality of life, disproportionate use of health care

resources, and significant adverse effects. Novel biologic therapeutics are being developed for the treatment of asthma and are of potential use for severe refractory asthma, especially where the increased cost of such agents is more likely justified.
This review will briefly summarize what is meant by “biologic therapies” and then highlight recent published data on efficacy and safety of these therapies for asthma.

WHAT ARE BIOLOGIC THERAPIES?

Biologic therapies have revolutionized the treatment of many diseases including asthma. By definition, the term “biologics” or “biologicals” include a variety of protein based therapeutics, such as antibodies, soluble receptors (eg,etanercept), recombinant protein-based receptor antagonists (eg, pitrakinra) and other related structures. Their main advantages include the duration of action and highly specific and strong binding to the target of interest; their main disadvantages are the cost and need for parenteral administration. Most biologicals in clinical use are antibodies, and their generic names contain standard nomenclature as a suffix to

indicate their origins (Fig. 1). Initially, pure murine antibodies were created with hybridoma technology, generating therapies that were 100% mouse with generic names given the suffix “momab” (eg, ibritumomab); however, immunogenicity of mouse antibodies in human subjects caused reduced efficacy and increased risk of infusion reactions including anaphylaxis and death. To reduce immunogenicity, chimeric antibodies

(“ximabs” like rituximab) were engineered. These antibodies are a marriage of murine variable regions combined with human constant regions, creating antibodies that are
80% human. These were a step forward but still had the potential for being immunogenic. Humanized monoclonal antibodies (“zumabs” such as omalizumab) go one step further, where now only the hypervariable regions of the mouse antibody are retained,

while the remaining 95% of the antibody is molecularly replaced by human sequences.

In the latest approach, fully human antibodies (“umabs” such as adalimumab) can be created by using phage display technology and molecular biology or more directly by immunizing mice that have had their immunoglobulin genes replaced with human versions. Newer artificial antibody structures such as bispecific antibodies, mix 2 separate arms with 2 different binding specificities to target 2 different types of antigens [eg, a single antibody where one arm binds interleukin (IL)-4 and the other arm binds IL-13]. Standard nomenclature for mAbs identifies their source with the last 4 or 5 letters: -omab, murine: –ximab, chimeric: -zumab, humanized: and –umab, human. The middle part of the name reflects the disease indication for which the mAb was initially intended: -lim for immune and inflammatory diseases, -cir for cardiovascular disorders, and -tu for tumors or neoplastic conditions. The first 3 or 4 letters may be chosen by the sponsor. Modified (by adding the structure of a bispecific antibody) . In general, FDA-approved mAbs have emerged between 10 and 12 years after the date that the new technologies on which they were based were reported in the scientific literature. None of these newer antibody structures have been tried in asthma, so the remainder of this review will focus on available data with standard biologicals.
Here is a listing of the key focus on biomolecules for therapeutics:
IL-4    

It induces the IgE isotype switch and up-regulates expression of vascular cell adhesion molecule-1 on endothelium and a variety of TH2 chemokines, thus promoting recruitment of T lymphocytes, monocytes,                 basophils, and eosinophils to sites of allergic inflammation.  A clinical trial studied the soluble recombinant human IL-4 receptor (IL-4R), Nuvance in asthma. Nuvance inhibited a decline in FEV1 during inhaled corticosteroid withdrawal and was overall well tolerated.2,3 However, in subsequent clinical trials in patients taking only beta agonist, soluble IL-4R failed to demonstrate significant clinical efficacy. A phase I randomized double blind placebo controlled study evaluated the effects of pascolizumab, a humanized anti-IL-4 antibody, in 24 patients with mild to moderate asthma. Pascolizumab was well tolerated and no serious adverse events occurred.5 However, a phase IIa clinical trial in steroid-naive, mild to moderate asthmatics, did not demonstrate clinical efficacy. Because the IL-4 targeting studies have failed to demonstrate clinical efficacy, one can justify concluding that either IL-4R is not an effective therapeutic target in asthma.

TNF
a

Tumor necrosis factor (TNF) is a multifunctional proinflammatory cytokine produced by inflammatory cells including monocytes, macrophages, mast cells, smooth muscle cells, and epithelial cells. TNF may initiate airway inflammation by up-regulating adhesion molecules, mucin hypersecretion, and airway remodeling, and by synergizing with TH2 cytokines. Berry et al demonstrated that severe refractory asthmatics have evidence of up-regulation of TNF as compared with healthy controls and mild asthmatics.  Entanercept was evaluated in a small, randomized, double-blind placebo-controlled crossover study in 10 patients with severe refractory asthma and elevated TNF levels, 10 patients with mild to moderate asthma, and 10 control patients. Entanercept treatment was associated with improved FEV1, asthma related quality of life, and the concentration of methacholine needed to provoke a 20% decrease in FEV1. No serious adverse reactions were noted. In another double-blind, placebo-controlled, parallel group study, 38 patients with moderate asthma on inhaled corticosteroids were treated with infliximab. Although infliximab treatment did not improve the primary end point of morning peak expiratory flow, it decreased diurnal variation of the peak expiratory flow rate and asthma exacerbations. No serious adverse events were noted. Golimumab was recently evaluated in the largest randomized, double-blind, placebo-controlled study in 309 patients with severe, uncontrolled asthma. No significant differences were observed for the change in FEV1 or exacerbations. However, several serious adverse events occurred. There is no clear role for TNF in perpetuating asthma or asthma exacerbations.

CD4

CD4 T cells are likely to be involved as a source of proinflammatory cytokines in asthma. Keliximab is a monoclonal antibody that causes a transient reduction in the number of CD4 T cells. A double blind, randomized, placebo controlled study with 22 severe oral corticosteroid dependent asthmatics patients was completed. A subset of patients received the highest dose of keliximab (3.0 mg/kg). There was significant improvement of peak expiratory flow rates in the high dose treatment arm. However, CD4 T cells remained transiently reduced 14 days postinfusion, raising safety concerns.

CD23  

CD23 is a low-affinity immunoglobulin E receptor (FcRII) and is important in regulating IgE production. IDEC-152 is a chimeric monoclonal antibody directed against CD23. CD23 is expressed on

• T and B cells,
• neutrophils,
• monocytes, and
• macrophages.

CD23 is overexpressed in allergic disease and may be involved in IgE overproduction,

• which can lead to mast cell degranulation.

A phase I dose escalating placebo-controlled study in 30 asthmatics demonstrated that

• IDEC-152 caused a dose-dependent reduction in serum IgE concentrations.
  • No significant adverse events were reported

CD25

Airway inflammation is associated with activated CD25 T cells, IL-2, and soluble IL-2 receptors. Daclizumab is a humanized monoclonal antibody directed against the alpha subunit of the high affinity IL-2 receptor (CD25). This inhibits IL-2 binding and release of inflammatory cytokines. A randomized, double-blind, placebo-controlled, parallel group study was performed (115 patients, 88 to the treatment arm, 27 to placebo)to evaluate the efficacy of daclizumab in patients with moderate to severe asthma poorly controlled on inhaled corticosteroids. Treatment with daclizumab led to improvements in FEV1, daytime asthma symptoms, and rescue
2 agonist use,but the effects were modest.

IgE

Omalizumab is a humanized monoclonal anti-IgE antibody that binds free circulating IgE and prevents the interaction between IgE and high affinity (FcRI) and low affinity (FcRII) IgE receptors on inflammatory cells. Omalizumab also down-regulates the surface expression of FcRI on basophils, mast cells, and dendritic cells.  Omalizumab decreases free IgE levels and reduces FcRI receptor expression on mast cells and basophils. This results in decreased mast cell activation and sensitivity, leading to a reduction in eosinophil influx and activation. Anti-IgE treatment with omalizumab might result in decreased mast cell survival. Omalizumab also reduces dendritic cell FcRI receptor expression.  The primary end point in a phase III randomized prospective trial was the number of exacerbation episodes during the steroid reduction period and the stable steroid period. During the stable steroid phase, fewer omalizumab subjects than placebo subjects experienced one or more exacerbations (14.6 vs. 23.3%; P  0.009). During the steroid reduction phase, the omalizumab group had fewer subjects with exacerbations (21.3 vs. 32.3%; P  0.04). The median reduction in inhaled corticosteroid dose was significantly greater in the omalizumab group than in the placebo group (75 vs. 50%; P  0.001).  The efficacy of omalizumab was demonstrated in other clinical trials including INNOVATE.  INNOVATE was a double-blind, parallel-group study in which 419 subjects were randomized to receive omalizumab or placebo for 28 weeks. The omalizumab group had a 26% reduction in the rate of clinically significant exacerbations compared with placebo (.68 vs. .91, P  0.042).  A recent omalizumab observational study of 280 subjects demonstrates similar findings. After 6 months, they found a reduction in daily symptoms by 80%, nocturnal symptoms by 86%, asthma exacerbations by 82%, hospitalizations by 76%, unscheduled health care visits by 81%, and improvement in quality of life (Mini Asthma Quality of Life Questionnaire increased from 2.9 to 4.5 after 6 months of treatment).

Examining the effects of biologic agents provides unique and valuable insight into the pathobiology of asthma. Furthermore, it is an ideal opportunity to identify mechanisms inherent to severe refractory asthma. The development of biologic agents has been a slow and arduous process; however, a substantial amount of progress has been achieved. Although omalizumab is an expensive medical treatment, therapy may be cost effective in patients with uncontrolled severe persistent allergic asthma because the majority of the economic burden is in this population. Hopefully ongoing efforts with biologicals will lead to improved management options for our most severe asthma patients.

More information is available from the article:    World Allergy Organ J. 2010;3(6):188–194.    http://dx.doi.org/10.1097/WOX.0b013e3181e5ec5a
PMCID: PMC2922052 NIHMSID: NIHMS221446
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922052/figure/F2/  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922052/bin/waoj-3-188-g002.gif  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922052/figure/F3/  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922052/bin/waoj-3-188-g003.gif
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922052/

Related articles

• #Shopping# : Therapeutic antibody engineering: Current and future advances driving the strongest growth area in the pharmaceutical industry (Woodhead Publishing Series in Biomedicine) (lacking29inv.wordpress.com)
• Novartis has been confirmed as key speaker for SMi Group’s 9th Asthma & COPD event (prweb.com)
• Research and Markets: Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 – Market … (biomedreports.com)
• BioLineRx’s EDP-14, for Treatment of Severe and Persistent Asthma, to Enter the Company’s Main Thera (dailyfinance.com)

English: Overview of hybridoma technology and monoclonal antibody creation (Photo credit: Wikipedia)

Mast cells are involved in allergy. Allergies such as pollen allergy are related to the antibody known as IgE. Like other antibodies, each IgE antibody is specific; one acts against oak pollen, another against ragweed. (Photo credit: Wikipedia)

Emil von Behring (Photo credit: Wikipedia)

Diagram showing the production of monoclonal antibodies via hybridoma technology (Photo credit: Wikipedia)

 

0.000000 0.000000

Read Full Post »

• Follow Blog via Email

  Enter your email address to follow this blog and receive notifications of new posts by email.

  Join 2,514 other followers

  Follow

• Recent Posts

  • 15th Annual Personalized Medicine Conference at Harvard Medical School – THE PARADIGM EVOLVES, November 13 – 14, 2019 • Harvard Medical School, Boston, MA July 19, 2019
  • Charles River Laboratories – World Congress, Delivering Therapies to the Clinic Faster, September 23 – 24, 2019, Cambridge, MA July 19, 2019
  • 2019 Warren Alpert Foundation Award goes to Four Scientists for Seminal DIscoveries in OptoGenetics – Illuminating the Human Brain July 18, 2019
  • At Technical University of Munich (TUM) Successful Genetical modification of a patient’s own immune cells, T cell receptors, using CRISPR-Cas9 gene editing tool. The engineered T cells are very similar to the physiological immune cells. July 17, 2019
  • scPopCorn: A New Computational Method for Subpopulation Detection and their Comparative Analysis Across Single-Cell Experiments July 16, 2019
  • Engineered Bacteria used as Trojan Horse for Cancer Immunotherapy July 13, 2019
  • @BroadInstitute a shift from Permanently editing DNA to Temporarily revising RNA – An approach with promise for addressing the risk of developing Alzheimer’s by deactivating APOE4 – RESCUE: RNA Editing for Specific C to U Exchange, the platform builds on REPAIR: RNA Editing for Programmable A to I July 12, 2019
  • FIVE Forthcoming Books on CRISPR in 2019-2020: Flooded market or CRISPR-fatigued readers – Not to Worry !!!!! July 4, 2019
  • Prediction of Cardiovascular Risk by Machine Learning (ML) Algorithm: Best performing algorithm by predictive capacity had area under the ROC curve (AUC) scores: 1st, quadratic discriminant analysis; 2nd, NaiveBayes and 3rd, neural networks, far exceeding the conventional risk-scaling methods in Clinical Use July 4, 2019
  • The Health Care Benefits of Combining Wearables and AI July 2, 2019

• Archives

  Archives Select Month July 2019  (11) June 2019  (47) May 2019  (41) April 2019  (27) March 2019  (29) February 2019  (17) January 2019  (50) December 2018  (14) November 2018  (17) October 2018  (18) September 2018  (17) August 2018  (8) July 2018  (20) June 2018  (22) May 2018  (17) April 2018  (12) March 2018  (20) February 2018  (26) January 2018  (16) December 2017  (6) November 2017  (20) October 2017  (13) September 2017  (16) August 2017  (16) July 2017  (19) June 2017  (20) May 2017  (32) April 2017  (21) March 2017  (10) February 2017  (24) January 2017  (21) December 2016  (43) November 2016  (8) October 2016  (40) September 2016  (67) August 2016  (59) July 2016  (75) June 2016  (37) May 2016  (95) April 2016  (152) March 2016  (176) February 2016  (196) January 2016  (139) December 2015  (90) November 2015  (287) October 2015  (237) September 2015  (115) August 2015  (96) July 2015  (63) June 2015  (44) May 2015  (53) April 2015  (76) March 2015  (95) February 2015  (83) January 2015  (75) December 2014  (75) November 2014  (88) October 2014  (135) September 2014  (117) August 2014  (88) July 2014  (88) June 2014  (109) May 2014  (60) April 2014  (85) March 2014  (58) February 2014  (72) January 2014  (107) December 2013  (104) November 2013  (136) October 2013  (62) September 2013  (32) August 2013  (46) July 2013  (74) June 2013  (110) May 2013  (112) April 2013  (86) March 2013  (92) February 2013  (63) January 2013  (63) December 2012  (46) November 2012  (71) October 2012  (84) September 2012  (82) August 2012  (122) July 2012  (59) June 2012  (34) May 2012  (46) April 2012  (2)

• Categories

  Categories Select Category 3D Printing for Medical Application  (186)    3D Plotting Scaffolds  (37)    BioInks  (29)       Biopolymer Blend Open Porous  (13)       Dental Applications  (9)    BioPrinting in Regenerative Medicine  (49)       Cell Level  (7)       MicroEngineering Cell-Tissue & Systems  (21)       Tissue Engineering  (22)    Cardiovascular and Vascular Systems  (18)       Artificial Vascular Structures  (6)       Cardiovascular Tissue  (4)    Drug Development using MultiOrgan Chip  (10)    Drug Development/Formulation using 3D Printing  (5)    MEMS  (13)       Bio-MEMS  (9)    Organ-on-a-Chip  (8)    Programmable Sensors (Carbon Nano Tubes)  (4) 3rd Party IP: Drug DIscovery  (2) 4D Printing and Meta Materials  (8) Academic Publishing  (201) Advanced Drug Manufacturing Technology  (86)    Antimalarial Preparation  (7)    Autologous Cell Therapy  (10)    Automated Cell Processing  (10) AI  (4)    AI in healthcare  (3)    AI in Medical-Imaging  (4) Allergy and Infectious Diseases  (7) Alzheimer’s Disease  (145)    Etiology  (70)    Medical Device Therapies for Altzheimer’s Disease  (12)    Pharmacotherapy and Cell Activity  (47) Anticancer Resistance  (25) Aortic Valve: TAVR  (3) Art Exhibits on the Human Condition  (1) Art Inspires Science  (2) Artificial Heart  (2) Artificial Intelligence – General  (72)    An executive’s guide to AI  (3)    Artificial Intelligence – Breakthroughs in Theories and Technologies  (43)    Artificial Intelligence Applications in Health Care  (23)       Artificial Intelligence in CANCER  (1)       Artificial Intelligence in Health Care – Tools & Innovations  (14)    Artificial Intelligence in Medicine – Application for Diagnosis  (13)       Artificial intelligence applications for cardiology  (9)       Artificial Intelligence in Psychiatry  (1)    Artificial Intelligence in Medicine – Applications in Therapeutics  (13) Auditory and vision  (11) Autism Spectrum Disorders  (10) Autoimmune Inflammatory DIseases  (16)    Crohn’s disease  (4)    Tolerance-inducing Autoimmune Disease Therapeutics  (2)    Ulcerative Colitis  (3) Autophagosome  (2) Bacterial Resistance  (23) Behavior  (21) Behavioral Genetics  (17) Big Data  (49)    Intelligent Information Systems  (29) Bio Instrumentation in Experimental Life Sciences Research  (353)    Analytical Instruments Industry  (3)    Microfuidics  (4) Bio-Ethics  (2) BioBanking  (24) Biodegradable Drug-eluting Material  (3) Bioengineering & reverse engineering design  (27) BioIT: BioInformatics  (103) BioIT: BioInformatics, NGS, Clinical & Translational, Pharmaceutical R&D Informatics, Clinical Genomics, Cancer Informatics  (75)    Advanced Computing Platform  (2)    Pancreatic adenocarcinoma classifier  (2)    Simulation Modeling in NGS  (1) Biological Engineering  (10) Biological Networks  (160) Biological Networks, Gene Regulation and Evolution  (443) Biomarkers & Medical Diagnostics  (544)    VOC – Volatile Organic Compounds as BioMarkers  (1) Biomedical Measurement Science  (164) BioSimilars  (105) BioTechnology – Venture Creation  (104)    Foundations for supporting Science and Education  (11)    Philanthropy to Academic Institution  (2) BioTechnology – Venture Creation, Venture Capital  (89)    Seeking Talent  (2) BiVAD  (1) Blindness  (6) Bone Disease and Musculoskeletal Disease  (76) Brain Basis of Emotion  (3) Business Career Consideration  (1) Ca2+ triggered activation  (57) Calcium  (16) Calcium Signaling  (64) Calmodulin Kinase and Contraction  (31) Cancer – General  (122) Cancer and Current Therapeutics  (344)    interventional oncology  (23)       Breast Cancer – impalpable breast lesions  (10)       Prostate Cancer: Monitoring vs Treatment  (4) CANCER BIOLOGY & Innovations in Cancer Therapy  (1,014)    Anaerobic Glycolysis  (49)    Cachexia  (18)    Cancer Genomics  (33)       Circulating Tumor Cells (CTC)  (12)          Liquid Biopsy Chip detects an array of metastatic cancer cell markers in blood  (9)             mRNA  (3)          MagSifter chip  (1)       KRAS Mutation  (2)       Li-fraumeni syndrome.  (2)       TP53 – Germline mutations  (2)    cancer metabolism  (10)    Funding Opportunities for Cancer Research  (4)    Genomic Expression  (129)    Glioblastoma  (4)    Hexokinase  (14)    Loss of function gene  (14)    Metabolic Immuno-Oncology  (9)    Metastasis Process  (6)    Methylation  (28)    Microbiome and Responses to Cancer Therapy  (5)    Monoclonal Immunotherapy  (23)    mtDNA  (12)    Oxidative phosphorylation  (53)    Pancreatic cancer  (7)    Pyruvate Kinase  (27)    The NCI Formulary  (1)    tumor microenvironment  (5)    Warburg effect  (48) Cancer Informatics  (79) Cancer Prevention: Research & Programs  (111) Cancer Screening  (82) Cancer Vaccines: Targeting Cancer Genes for Immunotherapy  (17)    Engineering Enhanced Cancer Vaccines  (3) Cardiac and Cardiovascular Surgical Procedures  (281)    Aortic Valve: TAVR, TAVI vs Open Heart Surgery  (77)       Prosthesis-Patient Mismatch (PPM) in TAVI vs SAVR  (1)       TAVI vs Open Heart Surgery  (4)       Valve-in-Valve Procedure  (3)    Atrial Fibrilation (a-Fib), Cardiac Pacing and Arrhythmias  (12)    BackBeat’s Cardiac Neuromodulation Therapy (CNT) bioelectronic therapy  (1)    CABG  (42)    Cancer Surgery of the Heart  (10)    Cardiovascular Fluid Management: algorithms  (1)    Heart Transplant  (13)    Heart-Lung Transplant  (8)    Implantation  (1)    Left Main Coronary Artery Disease (LMCAD)  (3)    Mechanical Assist Devices: LVAD, RVAD, BiVAD, Artificial Heart  (19)    Mitral Valve: Repair and Replacement  (58)       TMVR – Transcatheter Mitral Valve Repair  (2)    PCI  (92)       Bioresorbable Vascular Scaffold (BVS)  (2)       Robotic-assisted percutaneous coronary intervention  (1)       Stent Retriever in endovascular thrombectomy  (1)    Peripheral Arterial Disease & Peripheral Vascular Surgery  (54)       Abdominal Aorta  (19)       Carotid Artery  (15)       Thoracic Aorta  (15)    Pulmonary Valve Replacement and Repair  (1)    Renal Denervation  (20)    Replacement  (1)    Tricuspid Valve Repair  (5)    Vena Caval Filters: Device for Prevention of Pulmonary Embolism and Thrombosis  (1) Cardiovascular Pharmacogenomics  (167) Cargo  (3) Cell Biology  (277) Cell Biology, Signaling & Cell Circuits  (616)    Apoptosis  (8)    Autophagy-Modulating Proteins  (2)    “Antibody–enzyme conjugates”  (1)    Cell Processing System in Cell Therapy Process Development  (12)    Endoplasmic reticulum  (2)    Enzymatic mechanism underlying the synthesis of adenosine triphosphate (ATP)  (1)    Ubiquitin  (3) Cerebrovascular and Neurodegenerative Diseases  (106)    Stroke  (2) Chemical Biology and its relations to Metabolic Disease  (451)    #BIGAxisSummit  (1)    Gut Microbiome and Obesity  (6) Chemical Genetics  (343) Child and Adolescent Psychiatry  (13) Childhood cancer  (9) Childhood malnutrition  (3) Circulating Progenitor Cells  (26)    Bone marrow derived cells  (16)    Endothelial cells  (7)    Umbilical cord cells  (6) Clinical & Translational  (229) Clinical Diagnostics  (203)    Mass automation of plasma proteins  (12) Clinical Genomics  (126) Coagulation Therapy and Internal Bleeding  (79) Cognition  (41) Commercialization  (18) Components and IRB related issues  (4) Computational Biology/Systems and Bioinformatics  (449)    Meta-analysis of transcriptome data  (5) Conference Coverage with Social Media  (405)    MassBio  (1) CRISPR/Cas9 & Gene Editing  (161)    CRISPR alternative for editing genes without cutting  (3)       CAST – Alternative to CRISPR/Cas9  (1)       Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration  (2)    CRISPR applied to Human Germ Line  (5)       Gene Editing Impact on Longevity  (2) CT  (18) Cytokines  (19) Cytoskeleton  (82) Developmental biology  (103) Diabetes Mellitus  (137)    Artificial Pancreas for Type1 Diabetes  (3)    Gestational diabetes  (1) Diagnostic Immunology  (48) Diagnostics and Lab Tests  (106)    Liquid Biopsy: Circulating Tumor Cells in Urine and Blood  (7) Digital HealthCare – biotech & internet joint ventures  (34) Disease Biology  (309) Disease Biology, Small Molecules in Development of Therapeutic Drugs  (473) DNA repair  (52)    Apoptosis  (10)    Autophagy  (10)    Cell death pathways  (14)    Proteolysis  (5)    Proteosome  (4) Drug Delivery Platform Technology  (127)    Drug Carrier Design  (7)       Medication Remote Compliance Monitoring  (3)    Exosomes: Natural Carriers for siRNA Delivery  (6) Drug Toxicity  (73) Ecosystems & Industrial Concentration in the Medical Device Sector  (172)    Cardiac & Vascular Repair Tools Subsegment  (128)    Exec Compensation in the Cardiac & Vascular Repair Tools Subsegment  (14)    Massachusetts Niche Suppliers and National Leaders  (20) Electronic Health Record  (7) Embryology  (23) Empathy  (6) Endocrine Diseases  (57) Enzyme Induction  (41)    ion-transporting enzyme  (1)    K + -ATPase.  (1)    Na +  (1) Epigenetics and Environmental Factors  (22) Ethics and Leadership  (4) Executive Compensation – Big Pharma  (3) Fat soluble vitamins  (4) FDA  (58) FDA Regulatory Affairs  (341)    FDA, CE Mark & Global Regulatory Affairs: process management and strategic planning – GCP, GLP, ISO 14155  (48)    ISO 10993 for Product Registration: FDA & CE Mark for Development of Medical Devices and Diagnostics  (30) Fiction and medicine  (4) Frontiers in Cardiology and Cardiovascular Disorders  (794)    Acute Myocardial Infarction  (47)       Cardiogenic Shock  (3)    Anemia in CVD Patients  (6)    Cardio-Oncology  (1)    Cardiomyopathy  (50)    Cardiovascular Research  (158)       Myocardial metabolism, Myocardial ischemia, Myocardial adenine nucleotide metabolism  (43)       Pre-Clinical Animal Model Development  (22)    Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Pulmonary Arterial Hypertension (PAH)  (18)    Cost of Inpatient Stay for Cardiovascular Diagnosis for Admission  (1)    Electrophysiology  (94)       Ablation Procedure vs Drug Therapy  (1)       Arrhythmia Detection with Machine Learning Algorithms  (3)       Genomic Analysis of EKG Electrophysiology Genomics  (2)       implantable cardioverter defibrillator (ICD) and External Defibrillation  (1)       implantable pacemaker  (1)       Rare heart rhythm disorders and Long QT syndrome (LQTS)  (3)    Epigenetics and Cardiovascular Risks  (53)    Heart Failure (HF)  (30)       Acute coronary syndrome  (5)       congestive heart failure  (15)    Medical Devices R&D and Inventions  (197)       Assist Devices: LV  (2)       RV  (1)       Stents & Tools  (85)       Valves & Tools  (63)    Origins of Cardiovascular Disease  (393)       Atherogenic Processes & Pathology  (162)       Congenital Heart DIsease  (33)          Genetic Mutations in Congenital Heart DIsease  (4)       inflammation independent of lipid levels  (9)       Systemic Inflammatory Diseases as CVD Risk  (5)    Pharmacotherapy of Cardiovascular Disease  (324)       HTN  (155)       HTN in Youth  (7)       Resident-cell-based  (41)       Subarachnoid Hemorrhage (SAH)  (1)    Spontaneous Coronary Artery Dissection (SCAD)  (6)    Stroke  (5)       endovascular thrombectomy  (2)    Vascular Diseases  (9) Future Pandemics Inform-graphics  (1) Gastroenterology  (35) Gene Regulation  (208) Gene Regulation and Evolution  (126) Genetics & Innovations in Treatment  (149) Genetics & Pharmaceutical  (181) Genome Biology  (880)    Exosomes  (22)    Gene Therapy & Gene Editing Development  (16)    mRNA Therapeutics  (8)    Mutagenesis  (22)    Single Cell Genomics  (10)    Single-cell sequencing  (6)    Variation in human protein-coding regions  (13) Genomic Endocrinology  (37) Genomic Testing: Methodology for Diagnosis  (401) Genomics Pharmacy  (34) Global Market of Medical Devices Technology  (1) Global Medical Publishers by Country  (1) Global Partnering & Biotech Investment  (43) GLP  (4) Glycobiology: Biopharmaceutical Production  (9) Glycobiology: Biopharmaceutical Production, Pharmacodynamics and Pharmacokinetics  (22) Health Care System by Country  (22)    Centers for Medicare & Medicaid Services  (4)    Health in Israel  (1)    United States  (10)       Hospital-based Medical Innovations  (3)       Medical Recertification and Maintenance of Certification (MOC)  (1) Health Economics and Outcomes Research  (355)    Women Health  (4)       Heart and Brain Disease in Women  (3) Health Law & Patient Safety  (143)    and Bioethics  (4)    Biotechnology  (4)    Health Law Policy  (3) HealthCare IT  (118) Healthcare Reform  (95)    Accountable Care Organizations  (22)    Affordable Care Act  (28)       Repair  (1)       Repeal ACA  (1)       Replace  (1)    Federal Budget Appropriations  (21)    Healthcare costs and reimbursement  (48)    Indigent Nutrition  (13)    Medicare and Medicaid  (20)    Prescription Drugs Costs  (18)    Skilled Nursing Facilities  (6)    Technology Capital Expenses  (13)    Uninsured and Underinsured  (18) Hematology  (96)    Acute lymphocytic leukemia  (18)    Acute myelocytic leukemia  (21)    Hematopoiesis  (48)    Lymphoma  (21) History and physical exam  (6) Human aging  (26) Human Immune System in Health and in Disease  (226) Human Sensation and Cellular Transduction: Physiology and Therapeutics  (19) Image Processing/Computing  (34) Imaging-based Cancer Patient Management  (114) Immuno-Oncology & Genomics  (113)    mRNA platform in Drug DIscovery  (4) Immunodiagnostics  (110)    Cancer-Immune Interactions  (11)    CNS-Immune Interface  (3)    Neuronal Circuits  (3) Immunology  (85)    Adaptive Immune Response to Biomaterials and Tissue Repair  (6)    Antibody Responses Predict Antigen Exposure  (5)    Cytokine Receptor Structure  (4)    Human Antibody Response  (7)    Human Circulating Antibody Repertoire  (5)    Human Naive B Cell Repertoire  (5)    MHC Repertoires for Antigen Prediction  (5)    Protection Against Autoimmune Disease  (5)    Synthetic Immunology: Hacking Immune Cells  (8) Immunotherapy  (93)    CAR-T  (8)    combination immunotherapies.  (6)    Efficacy of Anti-Tumor T Cells  (8)    Engineering Better T Cells  (7)    Immune Engineering  (9)    Immune Modulatory  (8)    Integrin-targeted Combination Immunotherapy  (5)    Modulating Macrophages in Cancer Immunotherapy  (7)    NK Cell-Based Cancer Immunotherapy  (13)    Synergistic Innate and Adaptive Immunotherapy  (9) Income Disparity  (1) Infectious Disease & New Antibiotic Targets  (132)    Antibiotic resistance  (4)    Viral diseases  (16) Infectious Disease Immunodiagnostics  (31)    Virology – Vector-borne DIsease  (4) Inflammasome  (24)    Anti-tumor necrosis factor drugs (TNF inhibitors)  (2) Innovation in Immunology Diagnostics  (94)    Universal Immune Cell Therapies (uICT)  (6) Innovations  (169)    R&D Expenditure  (1) Innovations in Neurophysiology & Neuropsychology  (125)    autism spectrum disorder  (1)    Circadian Rhythm and Sleep  (3)    hNPCs  (1)    Relapsing Multiple Sclerosis  (1) Intellectual Property  (67)    Disputes and Settlements  (8)    IP Valuation Models – Pricing Intangible Assets  (1)    Patent Law in Biotech  (11) Intellectual Property, Innovations, Commercialization, Investment in technological breakthrough  (98) International Global Work in Pharmaceutical  (187) Interventional Oncology: Radiofrequency Ablation, Transarterial Chemoembolization, Microwave Ablation and Irreversible Electroporation (IRE)  (11) Interviews with Scientific Leaders  (265)    Albany Medical Center Prize in Medicine and Biomedical Research  (1)    Annual Breakthrough Prize  (2)    Awards in Cardiology and Cardiovascular Medicine  (3)    Gerald D Aurbach Award for Outstanding Translational Research  (1)    Jessie Stevenson Kovalenko Medal – Medical Sciences  (1)    Lemelson-MIT Prize  (1)    Life Sciences Breakthrough Prize  (2)    Mosteller Statistician of the Year Award  (1)    Mourning the Loss of a Scientific Leader  (1)    National Academy of Sciences AWARDS  (1)    Nobel Prize WInners  (10)    Paul Marks Prize for Cancer Research  (1)    Russ Prize recognizes bioengineering achievements worldwide  (1)    The Dan David Prize  (5)    Warren Alpert Foundation Prize Recipients  (3)    Wolf Prize  (1)    Wolf Prize in Medicine  (1)    women in science  (2) Investment in Technological Breakthrough  (53) Ionic Transporters Na+  (25) IP Development by LPBI Group Team  (6) IP Development by LPBI Group Team & Other Organizations  (5) ISO 14155  (3) Joint Venture – SBH & M3DP: SOP and Arrangements  (1) Justice & Law  (1) K  (15) Lab-on-a-chip  (1) Landscape  (1) Lasers and photonics  (18)    Midrange IR spectroscopy  (1) Law and Medicine Conflicts  (11) Leadership, Power, Social Interlocking Connections  (10) Lipid metabolism  (108)    Fatty acids  (37)    Lipids  (37)    PCSK9 Inhibitor Therapy  (19) Lipidomics  (10) Liposome  (3) Liver & Digestive Diseases Research  (116) LPBI Group, e-Scientific Media, DFP, R&D-M3DP, R&D-Drug Discovery, US Patents: SOPs and Team Management  (80)    Award Nominations  (4)    BioMed e-Books e-Series by LPBI Group  (5)    Feedback from Investors: LPBI Portfolio of Five Businesses  (2)    LPBI Group Founder – Aviva Lev-Ari  (8) Massachusetts Academy of Sciences (MAS)    (1) Materials Science & Engineering  (26) Math  (12)    Great Discoveries  (7) Mechanical Assist Devices: LVAD  (3) Medical and Population Genetics  (190) Medical Devices R&D Investment  (232)    21st Century Cures Act  (2)    CE Mark & Global Regulatory Affairs: process management and strategic planning – GCP  (13)    Rhythm management device hardware: dual-chamber pacemakers  (1)       Systolic HTN  (1) Medical Imaging Technology  (45) Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound  (140)    Circumferential-Intravascular-Radioluminescence-Photoacoustic-Imaging (CIRPI)  (1)    Invasive FFR for PCI  (2)    MRI  (9)    Noninvasive Diagnostic Fractional Flow Reserve (FFR) CT  (2)    Ultra Sound  (5) Melatonin & Circadian Regulation  (7) Metabolism  (221)    Biochemical pathways  (132)       Enzymes and isoenzymes  (68)          Dehydrogenase  (14)          Kinase  (27)          Phosphatase  (8)          Phosphorylase  (21)          tyrosine decarboxylases  (2)    Inosine nucleotides  (8)    Leloir pathway  (6)    microbiome  (5)    Pentose monophosphate shunt  (14)    Pyridine nucleotides  (28)       Pyridine nucleotide transhydrogenase  (7) Metabolomics  (314) Methods  (36) Mg++  (10) Microbiologial genetics  (30) Microbiology  (56)    Virology  (9) Micronutrients  (15) Microvesicle  (6) Microwave Ablation and Irreversible Electroporation (IRE)  (1) Mobile Healthcare  (1) Molecular Genetics & Pharmaceutical  (367)    Organoids  (3) Monoclonal antibody therapy  (6) Mutant Gene Expression  (38) Myocardial adenine nucleotide metabolism  (5) Myocardial Ischemia  (24) Myocardial Metabolism  (34) Na-K transport  (39) Na-K-ATPase  (26) Nanotechnology for Drug Delivery  (84) Nephrology  (45) Nephrology & Regenerative medicine  (8) Neurodegenerative Diseases  (75)    hNPCs  (2)    MS  (4) Neurohumoral Transmission  (60)    Ca2+ triggered activation  (17)    Calmodulin  (11)    Parkinson’s disease dyskinesia levodopa  (1)    PKC  (13)    Synaptic vesicle  (18) Neurological Diseases  (105) Neuroscience  (115) Next Generation Sequencing (NGS)  (17)    Nanopore sequencing  (1) NIH Common Fund  (1) Nitric Oxide in Health and Disease  (134) Nuclear Medicine  (11) Nutrigenomics  (67) Nutrition  (192)    Nutritional Supplements: Atherogenesis, lipid metabolism  (47) Nutrition and Phytochemistry  (59)    Minerals in Medicine  (4)    Plant extract  (21) Nutrition Disorders  (28) Nutritional Supplements: Atherogenesis  (30) Obesity  (16) Oligonucleotide Therapeutics & Delivery  (4) Oncolytic virus & OncoViro-Therapy  (17)    Synthetic Virology  (1) Organ-on-a-Chip & 3D Printing in Life Sciences  (5) Pain: Etiology, Genetics & Innovations in Treatment  (22) Parasitology  (5)    Malaria  (4)    Tropical diseases  (1) Patents  (31) Patient Experience  (50)    Art therapy  (1)    Hospital reputation  (6)    Humor  (1)    Music therapy  (2)    Pain Alleviation  (7)    Patient Outlook  (19)    Reputation of Interventionist  (4)    Support Staff  (8)    Supportive therapies  (3)       laughfter  (1)    Surgical Procedure  (5) Patient Experience: Personal Memories of Invasive Medical Intervantion  (23) Patient’s Voice: Personal Experience with Invasive Medical Procedures  (15) Perioperative Statins at Noncardiac Surgery  (1) Personal Health Applications: Tech Innovations serves HealhCare  (29) Personalized and Precision Medicine & Genomic Research  (682)    Longevity  (1)    Patient-centered Medicine  (23)       cell-based therapy  (5)       stem cell biology and patient-specific  (5)    Personalized Medicine Coalition  (5)    Precision Cancer Medicine  (8) Phagophore  (1) Pharmaceutical Analytics  (254)    Pharmacologic toxicities  (61) Pharmaceutical Discovery  (90)    Rapid automation of plasma protein pools  (14) Pharmaceutical Drug Discovery  (164)    Drug Development Process  (27)       Drug Discovery Chemistry  (15)    drug repurposing  (3) Pharmaceutical Industry Competitive Intelligence  (321)    Pharmacovigilance  (2)    Value-based Drug Pricing  (7) Pharmaceutical R&D Informatics  (37) Pharmaceutical R&D Investment  (289) Pharmacodynamics and Pharmacokinetics  (19) Pharmacogenomics  (150) Photography Collection  (1) Physics  (11) Placenta  (4) Population genetics  (15) Population Health Management  (122)    U.S. Employment-to-Population Ratio  (1) Population Health Management, Genetics & Pharmaceutical  (445)    Evolution of Biology Through Culture  (4) Population Health Management, Nutrition and Phytochemistry  (141) Preimplantation Genetic Diagnosis and Reproductive Genomics  (8) Protein-energy malnutrition  (11) Proteomics  (349)    Amino acids  (49)    Proteins  (127) Pulmonary diseases  (12)    Lung and pulmonology  (11) Pulmonary pathology  (5) Radio Frequency (RF)-based Surgical Solutions  (2) REAL TIME Conference Coverage Twitter’s Hashtags and Handles per Presentation/session  (10) Regenerative Biology and Medicine  (75) Regulated Clinical Trials: Design, Methods, Components and IRB related issues  (263) Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics  (98) Reproductive Biology & Bio Instrumentation  (64) RNA Biology  (68)    RNA interference (RNAi) therapeutic  (2) RNA Biology, Cancer and Therapeutics  (51) RVAD  (1) SBIR, SBA, NIH, NSF  (2) Schizophrenia  (14) Scientific & Biotech Conferences: Press Coverage  (154) Scientific Publishing  (588)    Curation  (573)       Curation methodology  (34)       De novo synthesis  (15)       Dialectic  (17)       Discovery process  (69)       Evolutionary cognition  (53)       Experimental validation  (90)       Explanatory  (92)       Historical relevance  (71)       Technology Advance Assessment of  (66)       Theoretic convergence  (26)    Open Access Journals  (25) Scientist: Career considerations  (184)    Big Data & Analytics  (9)    Data Science  (6)    Women in Life Sciences  (8) Scoop.it  (17) Sensors & Analytics  (16) Sepsis  (2) Severe Autism  (3) Signaling  (92)    Phosphorylation  (39)    S-nitrosylation  (11)    Ubiquitinylation  (30) Signaling & Cell Circuits  (117) Small Molecules in Development of Therapeutic Drugs  (60) Social Development  (13) Specialized 3D BioPrinters (Cornea  (1) Statistical Methods for Research Evaluation  (136) Stem Cells for Regenerative Medicine  (162)    Cardiac muscle regeneration  (16)    Competition in regenerative stem cell science  (15)    Human neural progenitor sells  (5)    Skeletal muscle regeneration  (7) STORM  (1) Stress Disorders  (18) Substance Abuse  (4) Systemic Inflammatory Response Related Disorders  (153)    Inflammatory Pathophysiology  (2) Technology Transfer: Biotech and Pharmaceutical  (347) Tissue Engineering and Regenerative Medicine  (16) Tissue Microenvironment  (3) Transarterial Chemoembolization  (2) Transcriptomics  (37) Transformative Technologies in Healthcare  (6) Translational Science  (211)    Best evidence  (52)    Bias measurement tools  (2)    Evidence-based decision-making  (24)    Inferential analysis  (25)    Intra-rater error  (1)    Quality Assurance  (8)    Random Error  (2)    Systematic Error (Bias)  (5)    Total error  (2)    Translational Effectiveness  (49)    Translational Research  (84) Trends in Global Economy  (2) Uncategorized  (1,351) Unfolded Protein Response (UPR)  (4) US and Global Economy: Trends and Findings  (6) Venture Capital  (41)    Income Geographic Distribution  (2)    Institutional Capital Raised by Female Founders  (4) Vision  (6) Voices of Patients and Healthcare Providers  (14) Water Transporters  (7) Wearable Tech + Digital Health  (3) Anemia  (21) Neutropenia  (7) Neutrophilia  (8) Platelet count disorder  (8) Folate and B12  (7) Iron deficiency  (5) Myelodysplasia  (12) Myelofibrosis  (10)

• Meta

  • Register
  • Log in
  • Entries RSS
  • Comments RSS
  • WordPress.com

• • 2012pharmaceutical
  • Aashir Awan, Phd
  • Alan F. Kaul, PharmD., MS, MBA, FCCP
  • alexcrystal6
  • amnondanzig1724
  • anamikasarkar
  • apreconasia
  • aviralvatsa
  • David Orchard-Webb, PhD
  • danutdaagmailcom
  • Demet Sag, Ph.D., CRA, GCP
  • Dror Nir
  • evelinacohn
  • Gail S Thornton
  • Irina Robu
  • jdpmd
  • kellyperlman
  • Ed Kislauskis
  • larryhbern
  • lmulligan13gmailcom
  • marzankhan
  • megbaker58
  • pkandala
  • Rosalind Codrington, PhD
  • ritusaxena
  • Rick Mandahl
  • sjwilliamspa
  • stuartlpbi
  • Dr. Sudipta Saha
  • tildabarliya
  • zraviv06
  • zs22
Advertisements