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Archive for the ‘REAL TIME Conference Coverage Twitter’s Hashtags and Handles per Presentation/session’ Category

AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class III: 100 e-Proceedings and 50 Tweet Collections of Top Biotech and Medical Global Conferences, 2013-2025

Curator: Aviva Lev-Ari, PhD, RN

We had researched the topic of AI Initiatives in Big Pharma in the following article:

  • Authentic Relevance of LPBI Group’s Portfolio of IP as Proprietary Training Data Corpus for AI Initiatives at Big Pharma

https://pharmaceuticalintelligence.com/2025/11/15/authentic-relevance-of-lpbi-groups-portfolio-of-ip-as-proprietary-training-data-corpus-for-ai-initiatives-at-big-pharma/

 

We are publishing a Series of Five articles that demonstrate the Authentic Relevance of Five of the Ten Digital IP Asset Classes in LPBI Group’s Portfolio of IP for AI Initiatives at Big Pharma.

  • For the Ten IP Asset Classes in LPBI Group’s Portfolio, See

https://pharmaceuticalintelligence.com/portfolio-of-ip-assets/

The following Five Digital IP Asset classes are positioned as Proprietary Training Data and Inference for Foundation Models in Health care.
This Corpus comprises of Live Repository of Domain Knowledge Expert-Written Clinical Interpretations of Scientific Findings codified in the following five Digital IP ASSETS CLASSES:
 IP Asset Class I: Journal: PharmaceuticalIntelligence.com
6,250 scientific articles (70% curations, creative expert opinions.  30% scientific reports).
2.4MM Views, equivalent of $50MM if downloading an article is paid market rate of $30.

https://pharmaceuticalintelligence.com/vision/pharmaceuticalintelligence-com-journal-projecting-the-annual-rate-of-article-views/

 

• IP Asset Class II: 48 e-Books: English Edition & Spanish Edition.
152,000 pages downloaded under pay-per-view. The largest number of downloads for one e-Publisher (LPBI)
• IP Asset Class III: 100 e-Proceedings and 50 Tweet Collections of Top Biotech and Medical Global Conferences, 2013-2025
Article Summary by @Grok
Conclusions and Implications
LPBI Group’s IP Asset Class III assets are “rare, defensible” for Big Pharma AI, powering from R&D acceleration to equitable care. Technical Implications: Enables theme-specific models (e.g., oncology conferences) for diagnostics/trials. Business Implications: Boosts ROI on $500M investments; licensing for symposia/webinars. Unique Insight: As the sole record of speaker insights, these outpace public data for “frontier” inference—key in series for holistic pharma AI moats.Promotional with resource links (e.g., IP portfolio, biotech conference lists). Complements prior pieces by adding temporal/event depth.

• IP Asset Class V: 7,500 Biological Images in our Digital Art Media Gallery, as prior art. The Media Gallery resides in WordPress.com Cloud of LPBI Group’s Web site

• IP Asset Class X: +300 Audio Podcasts: Interviews with Scientific Leaders
BECAUSE THE ABOVE ASSETS ARE DIGITAL ASSETS they are ready for use as Proprietary TRAINING DATA and INFERENCE for AI Foundation Models in HealthCare.
Expert‑curated healthcare corpus mapped to a living ontology, already packaged for immediate model ingestion and suitable for safe pre-training, evals, fine‑tuning and inference. If healthcare domain data is on your roadmap, this is a rare, defensible asset.
The article TITLE of each of the five Digital IP Asset Classes matched to AI Initiatives in Big Pharma, an article per IP Asset Class are:
  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class I: PharmaceuticalIntelligence.com Journal, 2.5MM Views, 6,250 Scientific articles and Live Ontology

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-data-training-and-inference-by-lpbi-groups-ip-asset-class-i-pharmaceuticalintelligence-com-journal-2-5mm-views-6250-scientific-article/

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class II: 48 e-Books: English Edition & Spanish Edition. 152,000 pages downloaded under pay-per-view

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-training-data-and-inference-by-lpbi-groups-ip-asset-class-ii-48-e-books-english-edition-spanish-edition-152000/

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class III: 100 e-Proceedings and 50 Tweet Collections of Top Biotech and Medical Global Conferences, 2013-2025

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-training-data-and-inference-by-lpbi-groups-ip-asset-class-iii-100-e-proceedings-and-50-tweet-collections-of-top-biotech/

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class V: 7,500 Biological Images in LPBI Group’s Digital Art Media Gallery, as Prior Art

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-training-data-and-inference-by-lpbi-groups-ip-asset-class-v-7500-biological-images-in-lpbi-groups-digital-art/

 

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class X: +300 Audio Podcasts Library: Interviews with Scientific Leaders

https://pharmaceuticalintelligence.com/2025/11/22/ai-initiatives-in-big-pharma-grog-prompt-proprietary-training-data-and-inference-by-lpbi-groups-ip-asset-class-x-300-audio-podcasts-library-interviews-with-scientific-leaders/

 

In the series of five articles, as above, we are presenting the key AI Initiatives in Big Pharma as it was created by our prompt to @Grok on 11/18/2025:

  • What are PFIZER’s AI INITIATIVES?

@Grok Response:

x.com/i/grok/share/0ol5VOJsEYs11baXq4xkzNb0h

Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D timelines
Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker /Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable access to care and tools for community care

Partnerships and Education

–       Collaborations: IMI Big Picture for 3M – sample disease database

–       AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

–       Webinars of AI for biomedical data integration

–       Webinar on AI in Manufacturing

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

  • AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class III: 100 e-Proceedings and 50 Tweet Collections of Top Biotech and Medical Global Conferences, 2013-2025

The Left Column was written @Grok

The Right Column was written by Aviva Lev-Ari, PhD, RN

 

AI Initiative at Big Pharma

i.e., Pfizer

e-Proceedings: N = +100

and

Tweet Collections: N = +50

Generative AI tools that save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery and Development Acceleration Pfizer uses AI, supercomputing, and ML to streamline R&D timelines e-Proceeding of +100 TOP Conferences in Biotech, in Medicine, in Genomics, in Precision Medicine

https://pharmaceuticalintelligence.com/press-coverage/part-two-list-of-biotech-conferences-2013-to-present/

In these conferences the Frontier of Science was presented. These Proceedings are the ONLY written record of the events.

The tweet Collection are QUOTES of speakers on record. NOT ELSEWHERE available by name of speaker and affiliation

Clinical Trials and Regulatory Efficiency AI:

-Predictive Regulatory Tools

-Decentralize Trials

-inventory management

Disease Detection and Diagnostics:

–       ATTR-CM Initiative

–       Rare diseases

Generative AI and Operational Tools:

–       Charlie Platform

–       Scientific Data Cloud AWS powered ML on centralized data

–       Amazon’s SageMaker/Bedrock for Manufacturing efficiency

–       Global Health Grants:

Pfizer Foundation’s AI Learning Lab for equitable  access to care and tools for community care

Ingest to Charlie Platform ALL e-Proceedings of ALL Conferences

 

Apply GPT:

Training Data:

–       One conference at a time

–       All Conference on ONE subject matter, i.e., Immunotherapy, Oncolytic Virus Immunotherapy, Immune Oncology

Partnerships and Education

–       Collaborations: IMI Big Picture for 3M – sample disease database

–       AI in Pharma AIPM Symposium: Drug discovery and Precision Medicine

–       Webinars of AI for biomedical data integration

–       Webinar on Ai in Manufacturing

Use Past agendas to build Future Conference Agendas

Use Speakers Lists

Use topics covered in Employee training & and in Leadership development

Strategic Focus:

–       $500M R&D reinvestment by 2026 targets AI for Productivity

–       Part of $7.7B cost savings

–       Ethical AI, diverse DBs

–       Global biotech advances: China’s AI in CRISPR

Having access to +100 e-Proceedings vs Not having access to this resource is a make or break in Branding

 

CONCLUSIONS: The Voice of Dr. Stephen J. Williams PhD

PENDING

Article Summary of the ArticleTitle:

AI Initiatives in Big Pharma @Grok prompt & Proprietary Training Data and Inference by LPBI Group’s IP Asset Class III: 100 e-Proceedings and 50 Tweet Collections of Top Biotech and Medical Global Conferences, 2013-2025

Publication Date: November 22, 2025

Author/Curator: Aviva Lev-Ari, PhD, RN
(Curator; Posted by 2012pharmaceutical)
@Grok SOURCE:


Overview: Third in LPBI Group’s five-article series on AI-ready digital IP assets for Pharma companies. This installment highlights IP Asset Class III—100 e-proceedings and 50 tweet collections from top global biotech/medical conferences (2013-2025)—as a proprietary, expert-curated corpus of frontier science insights. Using a November 18, 2025, Grok prompt on Pfizer’s AI efforts, it maps these assets to pharma applications, stressing their role in training/inference for foundation models. Unlike prior classes (journal articles, e-books), this focuses on real-time event captures (e.g., speaker quotes, agendas) as unique, non-replicable data for efficiency, education, and branding in AI-driven R&D.

Main Thesis and Key Arguments

  • Core Idea: LPBI’s IP Asset Class III assets provide the “only written record” of +100 top conferences, with tweet collections as verbatim speaker quotes/affiliations—ideal for ingesting into AI platforms to amplify human expertise in combinatorial predictions. This supports Pfizer’s goals like 16,000-hour savings via generative AI, enabling subject-specific training (e.g., immunotherapy) and future agenda building.
  • Value Proposition: 150 total assets (100 e-proceedings + 50 tweet collections) form a live repository of domain knowledge, mapped to ontology for immediate AI use. Equivalent to $50MM value (aligned with series benchmarks); unique for branding (“make or break”) as no other source offers such curated event intel. Part of five AI-ready classes (I, II, III, V, X) for healthcare models.
  • Broader Context: Builds on series by emphasizing event-based data for partnerships/education; contrasts generic datasets with defensible, ethical expert interpretations for global equity (e.g., Pfizer’s AI Learning Lab).

AI Initiatives in Big Pharma (Focus on Pfizer)Reuses Grok prompt highlights, presented in a verbatim table:

Initiative Category
Description
Generative AI Tools
Save scientists up to 16,000 hours annually in literature searches and data analysis.
Drug Discovery Acceleration
Uses AI, supercomputing, and ML to streamline R&D timelines.
Clinical Trials & Regulatory Efficiency
Predictive Regulatory Tools; Decentralize Trials; Inventory management.
Disease Detection & Diagnostics
ATTR-CM Initiative; Rare diseases.
Generative AI & Operational Tools
Charlie Platform; Scientific Data Cloud (AWS-powered ML on centralized data); Amazon’s SageMaker/Bedrock for Manufacturing efficiency; Pfizer Foundation’s AI Learning Lab for equitable access to care and community tools.
Partnerships & Education
IMI Big Picture (3M-sample disease database); AI in Pharma AIPM Symposium (Drug discovery and Precision Medicine); Webinars on AI for biomedical data integration; Webinar on AI in Manufacturing.
Strategic Focus
$500M R&D reinvestment by 2026 for AI productivity; Part of $7.7B cost savings; Ethical AI with diverse DBs; Global biotech advances (e.g., China’s AI in CRISPR).
Mapping to LPBI’s Proprietary DataCore alignment table (verbatim extraction, linking Pfizer initiatives to Class III assets):
Pfizer AI Initiative
Class III Alignment (100 e-Proceedings + 50 Tweet Collections)
Generative AI Tools (16,000 hours saved)
(No specific mapping.)
Drug Discovery Acceleration
e-Proceedings of +100 TOP Conferences in Biotech, Medicine, Genomics, Precision Medicine (2013-2025). Frontier of Science presented; ONLY written record of events. Tweet Collections: Speaker QUOTES on record (not elsewhere available by name/affiliation).
Clinical Trials & Regulatory Efficiency
(No specific mapping.)
Disease Detection & Diagnostics (ATTR-CM, rare diseases)
(No specific mapping.)
Generative AI & Operational Tools (Charlie, AWS, etc.)
Ingest ALL e-Proceedings into Charlie Platform. Apply GPT: Training Data—one conference at a time; OR All Conferences on ONE subject (e.g., Immunotherapy, Oncolytic Virus Immunotherapy, Immune Oncology).
Partnerships & Education (IMI, AIPM, webinars)
Use Past Agendas/Speakers Lists/Topics for: Employee Training & Leadership Development; Build Future Conference Agendas.
Strategic Focus ($500M reinvestment, ethics)
Access to +100 e-Proceedings vs. None = Make or Break in Branding.

Examples: Subject clusters like Immunotherapy; resources include conference lists (2013-present) and e-proceedings deliverables.Methodologies and Frameworks

  • AI Training Pipeline: Ingest proceedings/tweets into Charlie/AWS (e.g., SageMaker); GPT processing per conference or theme for pre-training/fine-tuning/inference. Use ontology for semantic mapping; tweets for quote-based evals.
  • Productivity Model: Enhances Pfizer’s savings ($7.7B total) via event intel for education/partnerships; ethical diverse data for global grants (e.g., CRISPR AI).
  • Insights: Quote from Dr. Stephen J. Williams, PhD: Emphasizes strategic branding via access. Predicts revolution in AI education/leadership from historical agendas.

Conclusions and Implications

LPBI Group’s IP Asset Class III assets are “rare, defensible” for Big Pharma AI, powering from R&D acceleration to equitable care. Technical Implications: Enables theme-specific models (e.g., oncology conferences) for diagnostics/trials. Business Implications: Boosts ROI on $500M investments; licensing for symposia/webinars. Unique Insight: As the sole record of speaker insights, these outpace public data for “frontier” inference—key in series for holistic pharma AI moats.Promotional with resource links (e.g., IP portfolio, biotech conference lists). Complements prior pieces by adding temporal/event depth.
Let me know if you want series comparisons or dives into specific conferences!

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Real Time Conferecence Coverage: Advancing Precision Medicine Conference Philadelphia PA November 1,2 2024  Deliverables

Curator: Stephen J. Williams, Ph.D.

Below are deliverables in form of real Time conference coverage from the Advancing Precision Medicine Confererence held this year in Philadelphia, PA.  The meeting brought together scientists and clinicians to discuss the challenges faced in implementing genomics and proteomics into precision medicine decision making workflow.  As summarized by a future release at the 2025 ASCO, there are many issues and hindrances to incorporating data obtained from sequencing to make a personalized medicine strategy.  The meeting focused on two main disease states: oncology and cardiovascular however most of  the live meeting notes are from the oncology tract.  In general it was discussed there are three areas which need to be addressed to correctly and more frequently incorporate precision medicine and genomic panel testing into clinical decision making workflow:

  1.  access to testing panels and testing methodology for both doctors and patients
  2. expert interpretation of results including algorithms needed to analyze the data
  3. more education of molecular biology and omics data and methodology in medical school to address knowledge gaps between clinicians and scientists

The issues can be summarized by a JCO report to ASCO in 2022:

 Helen Sadik, PhDDaryl Pritchard, PhD https://orcid.org/0000-0003-2675-0371 dpritchard@personalizedmedicinecoalition.orgDerry-Mae Keeling, BScFrank Policht, PhDPeter Riccelli, PhDGretta Stone, BSKira Finkel, MSPHJeff Schreier, MBA, and Susanne Munksted, MS.  Impact of Clinical Practice Gaps on the Implementation of Personalized Medicine in Advanced Non–Small-Cell Lung Cancer. 2022: JCO Precision Oncology; Volume 6. https://doi.org/10.1200/PO.22.00246

Personalized medicine presents new opportunities for patients with cancer. However, many patients do not receive the most effective personalized treatments because of challenges associated with integrating predictive biomarker testing into clinical care. Patients are lost at various steps along the precision oncology pathway because of operational inefficiencies, limited understanding of biomarker strategies, inappropriate testing result usage, and access barriers. We examine the impact of various clinical practice gaps associated with diagnostic testing-informed personalized medicine strategies on the treatment of advanced non–small-cell lung cancer (aNSCLC).

The authors used a  Diaceutics’ Data Repository, a multisource database including commercial and Medicare claims and laboratory data from over 500,000 patients with non–small-cell lung cancer in the United States. They  analyzed the number of patients with newly diagnosed aNSCLC who could have, but did not, benefit from a personalized treatment. The analysis was focused on identifying the gaps and at which steps during care did gaps existed which precipitated either lack of use of precision medicine testing or incorrect interpretation of results.

Their conclusions were alarming:

Most patients with aNSCLC eligible for precision oncology treatments do not benefit from them because of clinical practice gaps. This finding is likely reflective of similar gaps in other cancer types. An increased understanding of the impact of each practice gap can inform strategies to improve the delivery of precision oncology, helping to fully realize the promise of personalized medicine.

The links to the live meeting notes are given below and collection of tweets follow (please note this meeting did not have a Twitter hashtag)

Real Time Coverage Advancing Precision Medicine Annual Conference, Philadelphia PA November 1,2 2024

https://pharmaceuticalintelligence.com/2024/11/01/real-time-coverage-advancing-precision-medicine-annual-conference-philadelphia-pa-november-12-2024/

Real Time Coverage Morning Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 1 2024

https://pharmaceuticalintelligence.com/2024/11/01/real-time-coverage-morning-session-on-precision-oncology-advancing-precision-medicine-annual-conference-philadelphia-pa-november-1-2024/

Real Time Coverage Afternoon Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 1 2024

https://pharmaceuticalintelligence.com/2024/11/01/real-time-coverage-afternoon-session-on-precision-oncology-advancing-precision-medicine-annual-conference-philadelphia-pa-november-1-2024/ 

Real Time Coverage Morning Session on Precision Oncology: Advancing Precision Medicine Annual Conference, Philadelphia PA November 2 2024

https://pharmaceuticalintelligence.com/2024/11/04/real-time-coverage-morning-session-on-precision-oncology-advancing-precision-medicine-annual-conference-philadelphia-pa-november-2-2024/ 

Tweet Collection

Tweet Collection Advancing Precision Medicine Conference November 1,2 2024 Philadelphia PA

 

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Real Time Conference Coverage: Advancing Precision Medicine Conference, Philadelphia, October 3–4, 2025 – DELIVERABLES

Conference Press Coverage and Scientific Reporting

Reporter: Stephen J. Williams, PhD

Leaders in Pharmaceutical Business Intellegence will be covering this conference

LIVE over X.com at

@pharma_BI

@StephenJWillia2

@AVIVA1950

@AdvancingPM

using the following meeting hashtags:

@AdvancingPM  #WINSYMPO2025

Post #1

Select Conference Coverage 2025 Advancing Precision Medicine Conference, Philadelphia PA October 3-4 2025

https://pharmaceuticalintelligence.com/2025/10/02/conference-coverage-2025-advancing-precision-medicine-conference-philadelphia-pa-october-3-4-2025/

 

Post #2

Select Real Time Conference Coverage: Advancing Precision Medicine Conference,Morning Session Track 1 October 3 2025

https://pharmaceuticalintelligence.com/2025/10/03/real-time-conference-coverage-advancing-precision-medicine-conferencemorning-session-track-1-october-3-2025/

 

Post #3

Select Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Session Track 1 October 3 2025

https://pharmaceuticalintelligence.com/2025/10/03/real-time-conference-coverage-advancing-precision-medicine-conference-afternoon-session-track-1-october-3-2025/

 

Post #4

Select Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Omics Session Track 2 October 3 2025

https://pharmaceuticalintelligence.com/2025/10/03/real-time-conference-coverage-advancing-precision-medicine-conference-afternoon-omics-session-track-2-october-3-2025/

 

Post #5

Select Real Time Conference Coverage: Advancing Precision Medicine Conference, Early Morning Session Track 1 October 4 2025

https://pharmaceuticalintelligence.com/2025/10/04/real-time-conference-coverage-advancing-precision-medicine-conference-early-morning-session-track-1-october-4-2025/

 

Post #6

Select Real Time Conference Coverage: Advancing Precision Medicine Conference, MidMorning Session Track 1 October 3 2025

https://pharmaceuticalintelligence.com/2025/10/04/real-time-conference-coverage-advancing-precision-medicine-conference-midmorning-session-track-1-october-3-2025/

 

Post #7

Select Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Session Track 1 October 3 2025

https://pharmaceuticalintelligence.com/2025/10/04/real-time-conference-coverage-advancing-precision-medicine-conference-afternoon-session-track-1-october-3-2025-2/

 

Post #8

Select Real Time Conference Coverage: Advancing Precision Medicine Conference, Late Morning Session Track 1 October 4 2025

https://pharmaceuticalintelligence.com/2025/10/04/real-time-conference-coverage-advancing-precision-medicine-conference-late-morning-session-track-1-october-4-2025/

 

Post #9

Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Session, October 4 2025

https://pharmaceuticalintelligence.com/2025/10/04/real-time-conference-coverage-advancing-precision-medicine-conference-afternoon-session-october-4-2025/

 

 

 

 

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Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Session October 4 2025

Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Session  October 4 2025

Reporter: Stephen J. Williams, PhD

Leaders in Pharmaceutical Business Intellegence will be covering this conference LIVE over X.com at

@pharma_BI

@StephenJWillia2

@AVIVA1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine #WINSYMPO2025

1:40 – 2:30

AI in Precision Medicine

Dr. Ganhui Lan
Dr. Xiaoyan Wang
Dr. Ahmad P. Tafti
Jen Gilburg

Jen Gilburg (moderator)Deputy Secretary of Technology and Entrepreneurship, Dept. of Community and Economic Development, Commonwealth of Pennsylvania

  • AI will help reduce time for drug development especially in early phase of discovery but eventually help in all phases
  • Ganhui: for drug regulators might be more amenable to AI in clinical trials; AI may be used differently by clinicians
  • nonprofit in Philadelphia using AI to repurpose drugs (this site has posted on this and article will be included here)
  • Ganhui: top challenge of AI in Pharma; rapid evolution of AI and have to have core understanding of your needs and dependencies; realistic view of what can be done; AI has to have iterative learning; also huge vertical challenge meaning how can we allign the use of AI through the healthcare vertical layer chain like clinicians, payers, etc.
  • Ganhui sees a challenge for health companies to understand how to use AI in business to technology; AI in AI companies is different need than AI in healthcare companies
  • 95% of AI projects not successful because most projects are very discrete use

2:00-2:20

Building Precision Oncology Infrastructure in Low- and Middle-Income Countries

Razelle Kurzrock, MD

Sewanti Limaye, MD, Director, Medical & Precision Oncology; Director Clinical and Translational Oncology Research, Sir HN Reliance Foundation Hospital & Research Centre, Mumbai, India; Founder, Nova Precision AI; Co-Founder, Iylon Precision Oncology; Co-Chair, Asia Pacific Coalition Against Lung Cancer; Co-Chair,  Asia Pacific Immuno-Oncology; Member,  WIN Consortium

  • globally 60 precision initiatives but there really are because many in small countries
  • three out of five individuals in India die of cancer
  • precision medicine is a must and a hub and spoke model is needed in these places; Italy does this hub and spoke; spokes you enable the small places and bring them into the network so they know how and have access to precision medicine
  • in low income countries the challenge starts with biopsy: then diagnosis and biomarker is issue; then treatment decision a problem as they may not have access to molecular tumor boards
  • prevention is always a difficult task in LMICs (low income)
  • you have ten times more patients in India than in US (triage can be insurmountable)
  • ICGA Foundation: Indian Cancer Genome Atlas
  • in India mutational frequencies vary with geographical borders like EGFR mutations or KRAS mutations
  • genomic landscape of ovarian cancer in India totally different than in TCGA data
  • even different pathways are altered in ovarian cancer seen in North America than in India
  • MAY mean that biomarker panels need to be adjusted based on countries used in
  • the molecular data has to be curated for the India cases to be submitted to a tumor board
  • twenty diagnostic tests in market like TruCheck for Indian market; uses liquid biopsy
  • they are also tailoring diagnostic and treatment for India getting FDA fast track approvals

2:20-2:40

Co-targeting KIT/PDGRFA and Genomic Integrity in Gastrointestinal Stromal Tumors

Razelle Kurzrock, MD

Lori Rink, PhD, Associate ProfessorFox Chase Cancer Center

  • GIST are most common nesychymal tumor in GI tract
  • used to be misdiagnosed; was considered a leimyosarcoma
  • very asymptomatic tumors and not good prognosis
  • very refractory to genotoxic therapies
  • RTK KIT/PDGFRA gain of function mutations
  • Gleevec imatinib for unresectable GIST however vast majority of even responders become resistant to therapy and cancer returns
  • there is a mutation map for hotspot mutations and sensitivity for gleevec
  • however resistance emerged to ripretinib; in ATP binding pocket
  • over treatment get a polyclonal resistance
  • performed a kinome analysis; Wee1 looked like a potential target
  • mouse studies (80 day) showed good efficacy
  • avapiritinib ahs some neurotox and used in PDGFRA mut GIST model which is resistant to imitinib
  • but if use Wee1 inhibitor with TKI can lower dose of avapiritinib
  • cotargeting KIT/PDGFRA and WEE1 increases replicative stress
  • they are using PDX models to test these combinations
  • combination creates genomic instability

 

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Real Time Conference Coverage: Advancing Precision Medicine Conference, Late Morning Session Track 1 October 4 2025

Reporter: Stephen J. Williams, PhD

Leaders in Pharmaceutical Business Intellegence will be covering this conference LIVE over X.com at

@pharma_BI

@StephenJWillia2

@AVIVA1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine #WINSYMPO2025

SESSION 3

Advances in Precision Oncology:
From Genomics to Targeted Therapies

11:10-11:55

Breaking the Glass Ceiling: Targeting KRAS in Pancreatic Cancer

Razelle Kurzrock, MD
Razelle Kurzrock, MD

11:55-12:15

Charting the Future of Cancer Care: Precision Oncology and the Power of Genomics

Razelle Kurzrock, MD

12:15-12:35

Molecular Pathology as a Driver of Precision in Urological Cancers

Razelle Kurzrock, MD

12:30-12:40

Non – CME – dSTRIDE™-HR: A Functional Biomarker for In Situ, ‘real-time’ Detection and Quantification of Homologous Recombination Activity.

Magda Kordon-Kiszala, PhD

Magda Kordon-Kiszala, PhDCEO and co-founder, intoDNA

12:35-12:55

Epigenetic Plasticity and Tumor Evolution: Mechanisms of Resistance in Precision Oncology

Johnathan R. Whetstine, PhD

Johnathan R. Whetstine, PhDDirector, Cancer Epigenetics Institute, Director, Geonomics Resource, Fox Chase Cancer Center

  • Title: Epigenetic plasticity a gatekeeper to generating extrachromosomal DNA amplification and rearrangements
  • genetic events in cancer are actually controlled not random as he says
  • Fox Chase Cancer Center Epigenetics Institute; 5th year goal to understand epigenetic mechanisms to understand resistance and biomarker development; bring others and break down silos;  they are expanding and hiring and bringing into a network; March 5 2026 5th Annual Symposium Philadelphia Franklin Institute
  • DNA amplification is also chromosomal: integrated same locus or different regions or chromosomal duplication
  • KDM4A epigenetic demethylase controls transiet site specific DNA re-replication; can have focal control of DNA regions
  • you can control regional control of like EGFR amplification
  • can use Cy3 to find local regions
  • KDM3B inhibitor promotes transiet copy gains in KMT2A/MLL
  • EHMT2 is lysine demethylase is a driver of this copy amplification
  • this demethylase can change expression locally in one hour.. very fast
  • demethylases are very specific for their gene locus they control and so this demethylase only controls MLL gene
  • doxorubicin topoisomerase inhibitor can cause LOH in MLL locus and methylase inhibitor can reverse this
  • over twenty combinatorial regulators so this field is just budding

11:30-12:30

Companion Diagnostics in Hereditary and Chronic Diseases – Development, Regulatory Approval, and Commercialization – Non-CME Discussion

Huw Ricketts

Huw Ricketts PhDSenior Director, CLIA Business Development, QIAGEN

Tricia Carrigan

Tricia Carrigan, PhDBC Biosolutions

Arushi Agarwal

Arushi Agarwal, MS,  Partner, Health Advances

Melissa Reuter

Melissa Reuter, MS, MBADirector, Precision Medicine Program Strategy, GSK

  • This is a session panel Discussion on the current state of companion diagnostic development, not just in oncology.  Regulatory aspects will be discussed
  • Arushi: There are alot of opportunities in non-oncology areas for companion diagnostics, and time to development may be an obstacle
  • Huw Rickets:  From a development standpoint most people are not looking at the diagnostic side but more on the therapeutic side.
  • Tricia:  There needs to be a shift in oncology drug development world, and pharma sees developing diagnostic is too expensive.
  • Meliisa: They try to engage early with the agencies to understand the regulatory landscape; GSK is very strong in their oncology platform but there are gaps in diagnostics and non-oncology programs
  • Arushi: seems in Pharma oncology and non-oncology programs seems siloed
  • for non-oncology many of the biomarkers may be rare… well under 25% of population
  • Huw: Qiagen trying to develop diagnostics for Parkinson’s but those rare genetic diseases are easier to develop
  • Arushi: neurodegenerative, NASH, and immuno diseases are big areas where companies are looking to make companion diagnostics
  • Huw: kidney  disease is a big focus to develop companion diagnostics for

 

12:30-12:40

Non – CME – dSTRIDE™-HR: A Functional Biomarker for In Situ, ‘real-time’ Detection and Quantification of Homologous Recombination Activity.

Magda Kordon-Kiszala, PhD

Magda Kordon-Kiszala, PhDCEO and co-founder, intoDNA

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WMIF25 – World Medical Innovation Forum, Sept. 15-17, 2025, Boston

Clinical experts, industry, investment leaders

https://2025.worldmedicalinnovation.org/

 

I, Aviva Lev-Ari, PhD, RN had covered the WMIF Conference since it was launched 11 years ago, including WMIF24.

 

#WMIF19 was a special conference with the focus on AI in Medicine

The #WMIF19 Influencers via ‘s  Hashtags http://bit.ly/WMIF19 – By Mentions and By Tweets Ranked #4: @pharma_BI and #2: @AVIVA1950, respectively. Ranked #3 via NodeXL’s Betweenness Centrality http://bit.ly/2KB6cPN

https://pharmaceuticalintelligence.com/2019/04/13/the-wmif19-influencers-via-symplurs-healthcare-hashtags-http-bit-ly-wmif19-by-mentions-and-by-tweets-ranked-4-pharma_bi-and-2-aviva1950-respectively-ranked-3-via-node/

 

9/15/2025 – 9/17/2025 – I did not attended In-person WMIF25.

  • I was invited to cover the event in real time, as follows:

From: “Doyle, Tracy” <tdoyle5@mgb.org>
Date: Wednesday, August 20, 2025 at 11:07 AM
Cc: “Yiannacopoulos, John” <john.yiannacopoulos@bofa.com>, “Doyle, Tracy” <tdoyle5@mgb.org>
Subject: Media Invite: World Medical Innovation Forum, Sept. 15-17, Boston — Clinical experts, industry, investment leaders

Media Invite: World Medical Innovation Forum: Monday, Sept. 15 — Wednesday, Sept. 17, Boston – Innovation at Scale

 

VIDEOS from this Conference on Youtube.com

https://www.youtube.com/results?search_query=WMIF

 

Selected Speakers:

Peter Arduini

CEO, GE HealthCare

 

Eliav Barr, MD

 

SVP, Chief Medical Officer and Head of Global Clinical Development, Merck

Meredith Fisher, PhD

 

Partner, Mass General Brigham Ventures

Jean-François Formela, MD

 

Partner, Atlas Venture

Adele Gulfo

 

President & CEO, Biopharma Strategies and Insights

Jason Hafler, PhD

 

Managing Director, Sanofi Ventures

Rajiv Kaul

 

Portfolio Manager, Fidelity Investments

Paul LaViolette

 

Managing Partner, SV Health Investors

David Liu, PhD

 

Richard Merkin Professor; Director, Merkin Institute of Transformative Technologies in Healthcare, Broad Institute

Paul Matsen

 

Chief Marketing and Communications Officer, Cleveland Clinic

Michael Mihm, PhD

 

Asset Lead, Astellas Pharma

Bernd Montag, PhD

 

CEO, Siemens Healthineers

Michael Quigley, PhD

 

Chief Scientific Officer, Global Head of Research, Sanofi

John Reed, MD, PhD

 

Executive Vice President, Innovation Medicine, R&D, Johnson & Johnson

David Reese, MD

 

EVP & Chief Technology Officer, Amgen

David Rhew, MD

 

Global Chief Medical Officer & VP Healthcare, Microsoft

Jay Rughani

 

Investing Partner, Andreessen Horowitz

Gaurav Singal, MD

 

Independent advisor and investor

Ariel Stern, PhD

 

Alexander von Humboldt Professor, Hasso Plattner Institute

Ricky Sun, PhD

 

Partner, Bain Capital

Andrew Trister, MD, PhD

 

Chief Medical and Scientific Officer, Verily [Google]

Christopher Viehbacher

 

CEO, Biogen

Erin Xie, PhD

 

Managing Director, BlackRock

 

1:1 firesides and panels with top experts including:

Amy Abernethy MD, PhD, Cofounder, Highlander Health

Peter Arduini, CEO, GE HealthCare

Jeffrey Balser MD, PhD, CEO, Vanderbilt University Medical Center

Eliav Barr MD, Chief Medical Officer, Merck

Tom Frohlich, CEO, Jade Biosciences

David Hyman MD, Chief Medical Officer, Eli Lilly

Rajiv Kaul, Portfolio Manager, Fidelity

Anne Klibanski MD, CEO, Mass General Brigham

Robert Langer ScD, Institute Professor, MIT

Anu Madgavkar, Partner, McKinsey Global Institute

Kevin Mahoney, CEO, UPenn Health System

Paul Matsen, Chief Marketing and Communications Officer, Cleveland Clinic

Bernd Montag PhD, CEO, Siemens Healthineers

Dinesh Patel, PhD, CEO, Protagonist Therapeutics

Xiayang Qiu, PhD, CEO, Regor Therapeutics

Mike Quigley, CSO, Sanofi

David Rhew, Global Chief Medical Officer & VP Healthcare, Microsoft

Ken Song, MD, CEO, Candid Therapeutics

David Sontag PhD, CEO, Layer Health

Chris Viehbacher, CEO, Biogen

 

Government and regulatory experts including:

Larry Bucshon MD, Senior Policy Advisor, Holland & Knight; Former U.S. Representative (Indiana, 2011–2025)

Robert Califf MD, Instructor in Medicine, Duke University; Former Commissioner, U.S. Food and Drug Administration

Susan Collins, Senior U.S. Senator from Maine

Maura Healey, Governor of the Commonwealth of Massachusetts

Susan Monarez PhD, Director, Centers for Disease Control and Prevention

 

Deep-Dive KOL and Focused Sessions including:

  • Emerging Treatments: Cancer, Cardiovascular Disease, Obesity & Metabolic Diseases
  • AI at the Bedside — Physician Co-Pilots
  • Upending the U.S. Care Model
  • Antimicrobial Resistance – An Urgent, Global Crisis
  • The Silver Tsunami – Unprecedented and Unceasing
  • Institutional Investor Perspectives
  • Innovations in Disability Technology
  • Consumerism in Healthcare
  • Tackling High-Priority Health Challenges in Under-Served Communities
  • Sleep – the Future of a Busy Market
  • Gene Editing – Precision Medicine in Practice
  • Hospital Venture Investing

 

Leading biotech and venture execs from companies such as:

  • Andreessen Horowitz
  • ArrePath
  • Bain Capital Life Sciences
  • Caris Life Sciences
  • Enable Ventures
  • Fidelity Investments
  • Intellia Therapeutics
  • Layer Health
  • Lightspeed Venture Capital
  • Novo Holdings Venture Investments
  • Viz.ai

Exclusive programming:  

  • First Look – 19 rapid-fire presentations on the latest research from leading Mass General Brigham scientists
  • Big Ideas – 100+ key opinion leaders in healthcare weigh in on solving the top un-met clinical needs in medicine today
  • Emerging Tech Zone – Hands-on exploration of some of the latest digital and AI-based healthcare technologies

 

 

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Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Session Track 1 October 3 2025

Reporter: Stephen J. Williams, PhD

Leaders in Pharmaceutical Business Intellegence will be covering this conference LIVE over X.com at

@pharma_BI

@StephenJWillia2

@AVIVA1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine #WINSYMPO2025

1:00 – 1:50

Lunch & Exhibits

TRACK 1  204BC

TRACK 2  204A

WIN SYMPOSIUM

MULTI-OMICS

1:50-4:05

SESSION 4

From Targets to Trials:
Translating Discovery into Impact

1:50-2:10

Beyond Checkpoint Inhibitors: Targeted Immunotherapeutic Approaches for the Management of Solid Tumors

Andrea Ferreira-Gonzalez

2:10-2:30

Implementing Molecular Profiling in Early Phase Clinical Trials: Precision from Bench to Bedside

Andrea Ferreira-Gonzalez

2:30-2:40

Q&A

Andrea Ferreira-Gonzalez
Andrea Ferreira-Gonzalez

2:40-3:20

Non- CME Session: Venture Philanthropy

Andrea Ferreira-Gonzalez

Eric Heil, MBAManaging PartnerMedical Excellence Capital

John Lehr, President & CEO, Parkinson's Foundation

John LehrPresident & CEOParkinson’s Foundation

Dr. Blaine Robinson

Dr. Blaine Robinson, PhDVice President of the Therapy Acceleration Program (TAP)Blood Cancer United

3:20-4:10

eNSCLC Testing

Andrea Ferreira-Gonzalez

4:10 – 4:25

Break and Exhibits

TRACK 1  204BC

TRACK 2  204A

WIN SYMPOSIUM

MULTI-OMICS

4:25-6:45

4:25-5:15

Transforming Pediatric Oncology: The Power of Precision Medicine

Andrea Ferreira-Gonzalez

Giselle L. Sholler, MD, Division Chief, Pediatric Hematology/Oncology/BMT, Penn State Hershey Children’s Hospital; Professor, Pediatrics and Pharmacology; Founder & Chair, Beat Childhood Cancer Consortium

Andrea Ferreira-Gonzalez

Wei Zhang, PhD, Hanes and Willis Family Professor in Cancer; Director, Cancer Genomics and Precision Oncology, Wake Forest Baptist Comprehensive Cancer Center

Andrea Ferreira-Gonzalez

Elias Sayour, MD, PhD, Professor, Neurosurgery and Pediatrics;  Assistant Dean,  Clinical Research, UF College of Medicine, Program Co-leader,  UF Health Cancer Center Immuno-Oncology and Microbiome (IOM) Program

Andrea Ferreira-Gonzalez

Milan Radovich, PhDSenior Vice President, Chief Scientific OfficerCaris Life Sciences

Andrea Ferreira-Gonzalez

Pei Wang, PhDProfessor, Genetic and Genomic SciencesIcahn School of Medicine at Mount Sinai

Abigail Moore

5:15-5:25

Informing therapy decisions for improved patient care

Ashley Varghese, PharmD, RPh

5:25-5:50

Liquid Biopsies and Resistance Monitoring in Targeted Therapies 

Andrea Ferreira-Gonzalez

Pashtoon Kasi, MD, MS, Medical Director, GI Medical Oncology, City of Hope

5:50-6:10

Liquid Biopsies in Clinical Practice: Transforming Precision Oncology Through Molecular Monitoring

Andrea Ferreira-Gonzalez

Hatim Husain, MD, Associate ProfessorUniversity of California, San Diego 

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Real Time Conference Coverage: Advancing Precision Medicine Conference, MidMorning Session Track 1 October 3 2025

Reporter: Stephen J. Williams, PhD

Leaders in Pharmaceutical Business Intellegence will be covering this conference LIVE over X.com at

@pharma_BI

@StephenJWillia2

@AVIVA1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine #WINSYMPO2025

0:40 – 11:10

Break and Exhibits

TRACK 1  204BC

TRACK 2  204A

WIN SYMPOSIUM

MULTI-OMICS

11:10 – 1:10

SESSION 2

The Evolution of Precision Oncology:

Integrating MRD, AI, and Beyond

11:10-12:00

Precision Cancer Consortium

Andrea Ferreira-Gonzalez
Andrea Ferreira-Gonzalez

Shruti Mathur, MSPharma Diagnostic Strategy Leader, Global Product Strategy (GPS), Genentech

Andrea Ferreira-Gonzalez

Daryl Pritchard, PhD, Interim President, Personalized Medicine Coalition

Andrea Ferreira-Gonzalez

Keith T. Flaherty, MD, FAACR, Director of Clinical Research, Massachusetts General Cancer CenterProfessor of Medicine, Harvard Medical School;
President-Elect: 2025-2026, American Association for Cancer Research (AACR) 

SESSION 3

The Shifting Landscape:

Tumor Plasticity and Resistance

12:00-12:20

Mathematical and Evolutionary Modeling in Precision Radiation Oncology

Andrea Ferreira-Gonzalez

Jacob Scott, MD, DPhil, Professor and Staff Physician-Scientist, CWRU School of Medicine and Cleveland Clinic

12:20-12:40

Plasticity and Persistence: The Role of EMT in Cancer Progression and Therapy Resistance

Andrea Ferreira-Gonzalez

Sendurai A. Mani, PhD, Professor of Pathology and Laboratory Medicine, Brown University; Associate Director of Translational Oncology, Brown University Legorreta Cancer Center

12:40-1:00

Targeting Molecularly Defined Subsets: Challenges in Translational Oncology

Andrea Ferreira-Gonzalez

Benedito A. Carneiro, MD, MS, Director, Clinical Research
Director, Cancer Drug Development; Associate Director, Division of Hematology/Oncology
Legorreta Cancer Center, Brown University Health

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Real Time Conference Coverage: Advancing Precision Medicine Conference, Early Morning Session Track 1 October 4 2025

Reporter: Stephen J. Williams, PhD

Leaders in Pharmaceutical Business Intellegence will be covering this conference LIVE over X.com at

@pharma_BI

@StephenJWillia2

@AVIVA1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine #WINSYMPO2025

 

8:55 – 10:35

SESSION 1

Precision For All:

Global Access, Real Cases, and Implementation Science

 

8:55-9:15

Results and Future Direction from WIN’s Data Science Paper

Razelle Kurzrock, MD

9:15-9:55

When Precision Gets Personal: WIN Consortium International Molecular Tumor Board Live

Andrea Ferreira-Gonzalez
Razelle Kurzrock, MD

Razelle Kurzrock, MD, FACP, Chief Medical Officer, WIN Consortium; Professor of Medicine, Associate Director, Clinical Research, Linda T. and John A. Mellowes Endowed Chair of Precision Oncology, MCW Cancer Center and Linda T. & John A. Mellowes Center for Genomic Sciences and Precision Medicine

Notes from Live Tumor Board from Live Tweets

Tumor board Live… Molecular profiling great for identifying synthetic lethal combinations work very well… Many oncologist not accepting recommendations of molec tumor board

Tumor board Live . Oncologists don’t always accept tumor board recommendations based on molecular profiling… Dr Baptiste at first felt constrained to use single agent but WINTER combo trial with molec profiling better

Tumor board Live… Oncologist may give pushback when molecular therapeutic targets identified.. like when methylomics give a result and tumor board suggest temazolamide

Tumor board Live… Oncologist may give pushback when molecular therapeutic targets identified.. like when methylomics give a result and tumor board suggest temazolamide

Tumor board Live… Oncologist may give pushback when molecular therapeutic targets identified.. like when methylomics give a result and tumor board suggest temazolamide

Pemetrexemed not always working but MTAP inhibitions may work

Tumor board Live… Discussion of ovarian cancer case women first presented with CRC BRCA mut but failed PARP inhibitor board is looking at immunotherapy NGS IHC performed

#WINconsortium

Fusions being detected by RNAseq at rate of 100 per month

Tumor board Live…. Theranostics are becoming part of molec tumor board … Radio labeled dual diagnostic therapeutic antibodies

Tumor board Live… Molecular profiling great for identifying synthetic lethal combinations work very well… Many oncologist not accepting recommendations of molec tumor board

SESSION 2

Expanding the Precision Frontier

9:55-10:25

Precision Oncology in the Immunotherapy Era: Biomarkers and Clinical Trial Innovation

Razelle Kurzrock, MD

Lillian Siu, MD, President, AACR 2025-2026; Director, Phase I Clinical Trials Program; Co-Director, Robert and Maggie Bras and Family Drug Development Program Clinical Lead, Tumor Immunotherapy Program; BMO Chair, Precision Cancer Genomics, Princess Margaret Cancer Centre Professor of Medicine, University of Toronto

  • Princess Margaret CC went to Merck got pembrolizumab from them but built a team platform of clinicians and scientists to work on INSPIRE trial
  • $11 million of grants, 13 major papers, great team science
  • did ctDNA from liquid biopsy and also looked at methylation patterns in cfDNA
  • looked at IFN stimulation and outcome to pembrolizumab
  • retro transposable elements found in INSPIRE program, maybe a predictor of immune sensitivity
  • they were able to correlate some of their findings with spatial omics
  • using spatial data they could look at hot versus cold head and neck cancer
  •  factors for response to immunotherapy: TMB, t cell infiltrate,  PDL1 etc
  • using AI with IHC slides as well as NGS data sets
  • as clinical trials become multiomics and AI with multiomics platforms data sharing will be critical for success

10:25 – 10:35

The Microbiome and Its Role in Cancer Development and Treatment Response

Razelle Kurzrock, MD

Sabine Hazan, MD, CEO, Ventura Clinical Trials; CEO, Progenabiome

  • microbiome research at the infancy so we don’t know much when comes to oncology
  • we need to compare microbiome between persons using NGS and other omics
  • we all have different microbiome even though microbiome ‘healthy’
  • lots of factors affect microbiome including surgery
  • families are similar in their microbiome but when looking at Alzheimers there are differences
  • first lab to find whole COVID in the stools
  • virus was different in different people, difference spike proteins. Virus mutates from lung to stool (gut)
  • in intrafamily patients had different microbiome upon COVID infection
  • bifodobacteria was found as a major part of microbiome altered in COVID but also lots of other diseases
  • lots of examples of host microbial symbiosis
  • they had an instance with throat tumor treated with microbiome and tumor receded without chemo
  • in a glioblastoma microbiome adjustment helped but changed positive response to immunotherapy

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Real Time Conference Coverage: Advancing Precision Medicine Conference, Afternoon Omics Session Track 2 October 3 2025

Reporter: Stephen J. Williams, PhD

Leaders in Pharmaceutical Business Intellegence will be covering this conference LIVE over X.com at

@pharma_BI

@StephenJWillia2

@AVIVA1950

@AdvancingPM

using the following meeting hashtags

#AdvancingPM #precisionmedicine #WINSYMPO2025

4:20-4:40

Andrea Ferreira-Gonzalez

 

  • APOE was marker for defining a long term survivor and short term survivor for ovarian cancer patients; the markers were in the stroma
  • there is spatial communication between tumor and underlying stroma
  • it is imperative to understand how your multiomics equipment images a tumor area before it laser captures and send to the MS system; can lose a lot of tissue and information based on differences in resolution
  • many of these multiomics systems are validated for the clinic in EU not US
  • multiomics spatial analysis allows you to image protein, metabolite, mRNA expression in the 3 dimensional environment of the tumor (tumor cells and stroma)
  • they are making a human tumor atlas
  • they say a patient who had tumor went home during COVID and took vaccine but got ill with vaccine; but came back to check tumor and tumor had greatly regressed because prevaccine the tumor was immunologically cold and post COVID vaccine any left over tumor showed great infiltration of immune cells

4:40-4:55

Andrea Ferreira-Gonzalez

Aruna Ayer, PhDVP, Multiomics, Innovation and Scientific AffairsBD Biosciences

  • BD Bioscience multiomics platform is modular and can add more omics levels in the platorm
  • for example someone wanted to look at T cells
  • people have added CRISPR screens on the omics platform
  • most people are using single cell spatial omics
  • they have a FACS on their platform too so you can look at single cell spatial omics and sort different cellular populations
  • very comparative to 10X Genomics platform
  • their proteomics is another layer you can add on their platform however with proteomics you can high background notice with spatial proteomics or a limited panel of biomarkers
  • Their OMICS Protein One panels are optimized for biology and tumor type.
  • get high quality multiomics data and proteomics data but in a 3D spatial format
  • developed Cellismo Data Visualization software tool

4:55-5:10

Andrea Ferreira-Gonzalez

Harsha Gowda, PhDSenior Principal Scientist, Director, Research & Lab Operations, Signios Bio

Signios Biosciences (Signios Bio) is the US-based arm of MedGenome, a global leader in genetic testing services, genomics research, and drug discovery solutions.

Signios Bio is a multiomics and bioinformatics company dedicated to revealing the intricate signals within biological data. We leverage the power of multiomics—integrating data from genomics, transcriptomics, proteomics, epigenomics, metabolomics, and microbiomics—to gain a comprehensive understanding of disease biology. Our AI-powered bioinformatics platform allows us to efficiently analyze these complex datasets, uncovering hidden patterns and accelerating the development of new therapies and diagnostics.

Through the integration of cutting-edge multiomics technologies, advanced bioinformatics, and the expertise of world-class scientists, we enable researchers and clinicians with comprehensive, end-to-end solutions to improve drug discovery and development and advance precision medicine.

As part of MedGenome, we have access to real-world evidence (RWE) from global research networks across the US, Europe, Asia, Africa, Middle East, and Latin America. This access enables us to work with our partners to uncover insights that can lead to new biomarkers and drug targets, ensuring that precision medicine is inclusive and effective for all.

https://www.signiosbiolcom 

  • their platform can do high throughput analysis of patient tumors (like gallbladder cancer) analyzing mutational spectrum with high dimensionality
  • they can integrate genomic and transcriptomics data to reveal multiple pathways affected in patient data
  • have used their platform to investigate spatial omics in lung cancer

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