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Tumor Associated Macrophages: The Double-Edged Sword Resolved? Writer/Curator: Stephen J. Williams, Ph.D. Cell-based immunity is vital for our defense against pathologic insult but recent evidence has shown the role of cell-based immunity, especially macrophages to play an important role in both the development and hindrance of tumor growth, including role in ovarian, hematologic cancers, melanoma, […]

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Interview with the co-discoverer of the structure of DNA: Watson on The Double Helix and his changing view of Rosalind Franklin Curator: Aviva Lev-Ari, PhD. RN As a new edition of The Double Helix hits bookshelves, Boing-Boing‘s Maggie Koerth-Baker takes the opportunity to interview James Watson about his characterization of Rosalind Franklin, who, Koerth-Baker says, “is unfairly maligned in […]

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Protecting Your Biotech IP and Market Strategy: Notes from Life Sciences Collaborative 2015 Meeting


  Protecting Your Biotech IP and Market Strategy: Notes from Life Sciences Collaborative 2015 Meeting Achievement Beyond Regulatory Approval – Design for Commercial Success Stephen J. Williams, Ph.D.: Reporter The Mid-Atlantic group Life Sciences Collaborative, a select group of industry veterans and executives from the pharmaceutical, biotechnology, and medical device sectors whose mission is to […]

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Voices of Global Citizens: Impact of The Coronavirus Pandemic Gail S. Thornton, M.A. Richard A. Mandahl, MBA and Sudipta Saha, PhD Lead Curators – e–mail Contacts:  gailsthornton@yahoo.com and  rmandahl@gmail.com and  sudiptasaha1977@gmail.com Voices of Patients Tested Positive to Coronavirus Infections in the US Voices of Nurses and Allied Health Care Professionals in the US in the Coronavirus Pandemic Voices of Physicians at Hospitals Caring for Coronavirus Pandemic Voices […]

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Expedite Use of Agents in Clinical Trials: New Drug Formulary Created – The NCI Formulary is a public-private partnership between NCI, part of the National Institutes of Health, and pharmaceutical and biotechnology companies Reporter: Aviva Lev-Ari, PhD, RN   Wednesday, January 11, 2017 New Drug Formulary Will Help Expedite Use of Agents in Clinical Trials istock/Astakhova […]

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Oncolytic Virotherapy for Pancreatic Cancer: Overcoming Obstacles in Oncolytic Virus Delivery Reporter: Aviva Lev-Ari, PhD, RN   We covered MGH’s Innovation on Tumor targeted therapy in Pancreatic Cancer in Pancreatic Cancer Targeted Treatment? Curator: Larry H. Bernstein, MD, FCAP https://pharmaceuticalintelligence.com/2016/05/18/pancreatic-cancer-targeted-treatment/   Below, we report on the State of the Science for Overcoming Obstacles in Oncolytic Virus […]

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Effect of mitochondrial stress on epigenetic modifiers Larry H. Bernstein, MD, FCAP, Curator LPBI   Early Mitochondrial Stress Alters Epigenetics, Secures Lifelong Health Benefits GEN 5/3/2016  http://www.genengnews.com/gen-news-highlights/early-mitochondrial-stress-alters-epigenetics-secures-lifelong-health-benefits/81252685/ A little adversity builds character, or so the saying goes. True or not, the saying does seem an apt description of a developmental phenomenon that shapes gene expression. […]

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Immune System Stimulants: Articles of Note @pharmaceuticalintelligence.com Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN   New Approaches to Immunotherapy   New Class of Immune System Stimulants: Cyclic Di-Nucleotides (CDN): Shrink Tumors and bolster Vaccines, re-arm the Immune System’s Natural Killer Cells, which attack Cancer Cells and Virus-infected Cells Three Methods for […]

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Oncolytic Virus Immuno-Therapy: New Approach for a New Class of Immunotherapy Drugs Curator: Larry H. Bernstein, MD, FCAP   Oncolytic viruses represent a promising novel immunotherapy strategy, which may be optimally combined with existing therapeutic modalities Oncolytic viruses: a novel form of immunotherapy Robin J Prestwich, Kevin J Harrington,  Hardev S Pandha, Richard G Vile, Alan […]

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Schizophrenia genomics Larry H. Bernstein, MD, FCAP, Curator LPBI   Histone Methylation at H3K9; Evidence for a Restrictive Epigenome in Schizophrenia Kayla A. Chase,1David P. Gavin,1Alessandro Guidotti,1 and Rajiv P. Sharma1 Schizophr Res. 2013 Sep; 149(0): 15–20.      doi:  10.1016/j.schres.2013.06.021 Epigenetic changes are stable and long-lasting chromatin modifications that regulate genomewide and local gene activity. […]

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