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Search Results for 'double edged'


Tumor Associated Macrophages: The Double-Edged Sword Resolved? Writer/Curator: Stephen J. Williams, Ph.D. Cell-based immunity is vital for our defense against pathologic insult but recent evidence has shown the role of cell-based immunity, especially macrophages to play an important role in both the development and hindrance of tumor growth, including role in ovarian, hematologic cancers, melanoma, […]

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Interview with the co-discoverer of the structure of DNA: Watson on The Double Helix and his changing view of Rosalind Franklin Curator: Aviva Lev-Ari, PhD. RN As a new edition of The Double Helix hits bookshelves, Boing-Boing‘s Maggie Koerth-Baker takes the opportunity to interview James Watson about his characterization of Rosalind Franklin, who, Koerth-Baker says, “is unfairly maligned in […]

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Protecting Your Biotech IP and Market Strategy: Notes from Life Sciences Collaborative 2015 Meeting


  Protecting Your Biotech IP and Market Strategy: Notes from Life Sciences Collaborative 2015 Meeting Achievement Beyond Regulatory Approval – Design for Commercial Success Stephen J. Williams, Ph.D.: Reporter The Mid-Atlantic group Life Sciences Collaborative, a select group of industry veterans and executives from the pharmaceutical, biotechnology, and medical device sectors whose mission is to […]

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Expedite Use of Agents in Clinical Trials: New Drug Formulary Created – The NCI Formulary is a public-private partnership between NCI, part of the National Institutes of Health, and pharmaceutical and biotechnology companies Reporter: Aviva Lev-Ari, PhD, RN   Wednesday, January 11, 2017 New Drug Formulary Will Help Expedite Use of Agents in Clinical Trials istock/Astakhova […]

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Oncolytic Virotherapy for Pancreatic Cancer: Overcoming Obstacles in Oncolytic Virus Delivery Reporter: Aviva Lev-Ari, PhD, RN   We covered MGH’s Innovation on Tumor targeted therapy in Pancreatic Cancer in Pancreatic Cancer Targeted Treatment? Curator: Larry H. Bernstein, MD, FCAP https://pharmaceuticalintelligence.com/2016/05/18/pancreatic-cancer-targeted-treatment/   Below, we report on the State of the Science for Overcoming Obstacles in Oncolytic Virus […]

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Effect of mitochondrial stress on epigenetic modifiers Larry H. Bernstein, MD, FCAP, Curator LPBI   Early Mitochondrial Stress Alters Epigenetics, Secures Lifelong Health Benefits GEN 5/3/2016  http://www.genengnews.com/gen-news-highlights/early-mitochondrial-stress-alters-epigenetics-secures-lifelong-health-benefits/81252685/ A little adversity builds character, or so the saying goes. True or not, the saying does seem an apt description of a developmental phenomenon that shapes gene expression. […]

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Immune System Stimulants: Articles of Note @pharmaceuticalintelligence.com Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN   New Approaches to Immunotherapy   New Class of Immune System Stimulants: Cyclic Di-Nucleotides (CDN): Shrink Tumors and bolster Vaccines, re-arm the Immune System’s Natural Killer Cells, which attack Cancer Cells and Virus-infected Cells Three Methods for […]

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Oncolytic Virus Immuno-Therapy: New Approach for a New Class of Immunotherapy Drugs Curator: Larry H. Bernstein, MD, FCAP   Oncolytic viruses represent a promising novel immunotherapy strategy, which may be optimally combined with existing therapeutic modalities Oncolytic viruses: a novel form of immunotherapy Robin J Prestwich, Kevin J Harrington,  Hardev S Pandha, Richard G Vile, Alan […]

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Schizophrenia genomics Larry H. Bernstein, MD, FCAP, Curator LPBI   Histone Methylation at H3K9; Evidence for a Restrictive Epigenome in Schizophrenia Kayla A. Chase,1David P. Gavin,1Alessandro Guidotti,1 and Rajiv P. Sharma1 Schizophr Res. 2013 Sep; 149(0): 15–20.      doi:  10.1016/j.schres.2013.06.021 Epigenetic changes are stable and long-lasting chromatin modifications that regulate genomewide and local gene activity. […]

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UPDATED – Status “Interference — Initial memorandum” – CRISPR/Cas9 – The Biotech Patent Fight of the Century: UC, Berkeley and Broad Institute @MIT Reporter: Aviva Lev-Ari, PhD, RN   UPDATED on 6/30/2019 Patent office renews dispute over patent rights to CRISPR-Cas9 By Public Affairs, UC Berkeley| JUNE 25, 2019   Schematic representation of the CRISPR-Cas9 system. The Cas9 […]

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