Tumor Associated Macrophages: The Double-Edged Sword Resolved? Writer/Curator: Stephen J. Williams, Ph.D. Cell-based immunity is vital for our defense against pathologic insult but recent evidence has shown the role of cell-based immunity, especially macrophages to play an important role in both the development and hindrance of tumor growth, including role in ovarian, hematologic cancers, melanoma, […]
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Tumor Associated Macrophages: The Double-Edged Sword Resolved?
Posted in Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Immuno-Oncology & Genomics, tagged Adaptive immune system, Biology, breast cancer, Cancer - General, Cancer immunology, Cell Biology, Conditions and Diseases, gene expression, genomics, macrophages, modulation of tumor tolerance, research, Stem cell, tumor associated macrophage, tumor microenvironment, Weill Cornell on September 15, 2015| 3 Comments »
Interview with the co-discoverer of the structure of DNA: Watson on The Double Helix and his changing view of Rosalind Franklin
Posted in Biological Networks, Gene Regulation and Evolution, Genome Biology, Interviews with Scientific Leaders, tagged DNA, Double Helix, Francis Crick, James D. Watson, Maurice Wilkins, Rosalind Franklin on November 9, 2012| 8 Comments »
Interview with the co-discoverer of the structure of DNA: Watson on The Double Helix and his changing view of Rosalind Franklin Curator: Aviva Lev-Ari, PhD. RN As a new edition of The Double Helix hits bookshelves, Boing-Boing‘s Maggie Koerth-Baker takes the opportunity to interview James Watson about his characterization of Rosalind Franklin, who, Koerth-Baker says, “is unfairly maligned in […]
Expedite Use of Agents in Clinical Trials: New Drug Formulary Created – The NCI Formulary is a public-private partnership between NCI, part of the National Institutes of Health, and pharmaceutical and biotechnology companies
Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Pharmaceutical Drug Discovery, Pharmaceutical Industry Competitive Intelligence, Pharmaceutical R&D Informatics, Pharmaceutical R&D Investment, Pharmacodynamics and Pharmacokinetics, The NCI Formulary on January 12, 2017| Leave a Comment »
Expedite Use of Agents in Clinical Trials: New Drug Formulary Created – The NCI Formulary is a public-private partnership between NCI, part of the National Institutes of Health, and pharmaceutical and biotechnology companies Reporter: Aviva Lev-Ari, PhD, RN Wednesday, January 11, 2017 New Drug Formulary Will Help Expedite Use of Agents in Clinical Trials istock/Astakhova […]
Oncolytic Virotherapy for Pancreatic Cancer: Overcoming Obstacles in Oncolytic Virus Delivery
Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Immuno-Oncology & Genomics on July 24, 2016| Leave a Comment »
Oncolytic Virotherapy for Pancreatic Cancer: Overcoming Obstacles in Oncolytic Virus Delivery Reporter: Aviva Lev-Ari, PhD, RN We covered MGH’s Innovation on Tumor targeted therapy in Pancreatic Cancer in Pancreatic Cancer Targeted Treatment? Curator: Larry H. Bernstein, MD, FCAP https://pharmaceuticalintelligence.com/2016/05/18/pancreatic-cancer-targeted-treatment/ Below, we report on the State of the Science for Overcoming Obstacles in Oncolytic Virus […]
Oncolytic Virus Immuno-Therapy: New Approach for a New Class of Immunotherapy Drugs
Posted in Immunology, Immunotherapy, Innovation in Immunology Diagnostics, Innovations, Intellectual Property, Innovations, Commercialization, Investment in technological breakthrough, Virology, tagged adaptive, Clinical trial, immune response, Immunotherapy, innate, Oncolytic virus & OncoViro-Therapy on April 12, 2016| Leave a Comment »
Oncolytic Virus Immuno-Therapy: New Approach for a New Class of Immunotherapy Drugs Curator: Larry H. Bernstein, MD, FCAP Oncolytic viruses represent a promising novel immunotherapy strategy, which may be optimally combined with existing therapeutic modalities Oncolytic viruses: a novel form of immunotherapy Robin J Prestwich, Kevin J Harrington, Hardev S Pandha, Richard G Vile, Alan […]
Schizophrenia genomics
Posted in Genome Biology, Mutant Gene Expression, Neurological Diseases, Neuroscience, Schizophrenia, tagged Akt/PKB, autism spectrum disorders (ASDs), Chromatin, copy number variation (CNV), Epigenetics, histone methylation, Lymphocyte, methyl-CpG-binding domain (MBD), PDK2, PI3K/PTEN, Postmortem Brain, Rett syndrome, Schizophrenia, single nucleotide polymorphism (SNP) on March 15, 2016| Leave a Comment »
Schizophrenia genomics Larry H. Bernstein, MD, FCAP, Curator LPBI Histone Methylation at H3K9; Evidence for a Restrictive Epigenome in Schizophrenia Kayla A. Chase,1David P. Gavin,1Alessandro Guidotti,1 and Rajiv P. Sharma1 Schizophr Res. 2013 Sep; 149(0): 15–20. doi: 10.1016/j.schres.2013.06.021 Epigenetic changes are stable and long-lasting chromatin modifications that regulate genomewide and local gene activity. […]
UPDATED – Status “Interference — Initial memorandum” – CRISPR/Cas9 – The Biotech Patent Fight of the Century
Posted in CRISPR/Cas9 & Gene Editing, Intellectual Property, Intellectual Property, Innovations, Commercialization, Investment in technological breakthrough on January 6, 2016| Leave a Comment »
UPDATED – Status “Interference — Initial memorandum” – CRISPR/Cas9 – The Biotech Patent Fight of the Century: UC, Berkeley and Broad Institute @MIT Reporter: Aviva Lev-Ari, PhD, RN UPDATED on 6/30/2019 Patent office renews dispute over patent rights to CRISPR-Cas9 By Public Affairs, UC Berkeley| JUNE 25, 2019 Schematic representation of the CRISPR-Cas9 system. The Cas9 […]
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