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Oncolytic Virus Immuno-Therapy: New Approach for a New Class of Immunotherapy Drugs

Posted in Immunology, Immunotherapy, Innovation in Immunology Diagnostics, Innovations, Intellectual Property, Innovations, Commercialization, Investment in technological breakthrough, Virology, tagged adaptive, Clinical trial, immune response, Immunotherapy, innate, Oncolytic virus & OncoViro-Therapy on April 12, 2016| Leave a Comment »

Oncolytic Virus Immuno-Therapy: New Approach for a New Class of Immunotherapy Drugs Curator: Larry H. Bernstein, MD, FCAP Oncolytic viruses represent a promising novel immunotherapy strategy, which may be optimally combined with existing therapeutic modalities Oncolytic viruses: a novel form of immunotherapy Robin J Prestwich, Kevin J Harrington, Hardev S Pandha, Richard G Vile, Alan […]

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Principles of Gene Editing

Posted in Clinical & Translational, Clinical Genomics, CRISPR/Cas9 & Gene Editing, Curation, Genome Biology, Genomic Testing: Methodology for Diagnosis, tagged CRISPR/Cas9, DNA repair, DNA synthesis, gene editing on October 30, 2015| Leave a Comment »

Principles of Gene Editing Larry H. Bernstein, MD, FCAP, Curator LPBI EDITING Researchers are learning how to use synthetic RNA sequences to control the cutting of any piece of DNA they choose. The cell will repair the cut, but an imperfect repair may disable the gene. Or a snippet of different DNA can be inserted […]

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T cell-mediated immune responses & signaling pathways activated by Toll-like Receptors

Posted in Cell Biology, Signaling & Cell Circuits, Clinical & Translational, Curation, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Gene Regulation, Human Immune System in Health and in Disease, tagged cell-mediated immunity, Toll-like receptor on September 7, 2015| Leave a Comment »

T cell-mediated immune responses & signaling pathways activated by Toll-like Receptors Curator: Larry H. Bernstein, MD, FCAP Series E. 2; 6.10 Bruce A. Beutler, Jules A. Hoffmann, Ralph M. Steinman Bruce Beutler, MD Regental Professor; Raymond and Ellen Willie Distinguished Chair in Cancer Research, in Honor of Laverne and Raymond Willie, Sr. Department Center for […]

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Protecting Your Biotech IP and Market Strategy: Notes from Life Sciences Collaborative 2015 Meeting

Posted in Academic Publishing, Affordable Care Act, Bio Instrumentation in Experimental Life Sciences Research, BioSimilars, BioTechnology - Venture Creation, Venture Capital, Commercialization, Conference Coverage with Social Media, Diagnostics and Lab Tests, Drug Delivery Platform Technology, Ecosystems & Industrial Concentration in the Medical Device Sector, FDA, FDA Regulatory Affairs, Global Partnering & Biotech Investment, Health Economics and Outcomes Research, Health Law & Patient Safety, Healthcare costs and reimbursement, HealthCare IT, Healthcare Reform, Intellectual Property, Intellectual Property, Innovations, Commercialization, Investment in technological breakthrough, Interviews with Scientific Leaders, Investment in Technological Breakthrough, Medical Devices R&D and Inventions, Medical Devices R&D Investment, Medicare and Medicaid, Patents, Personal Health Applications: Tech Innovations serves HealhCare, Pharmaceutical Discovery, Pharmaceutical Industry Competitive Intelligence, Pharmaceutical R&D Investment, Population Health Management, Prescription Drugs Costs, Scientific & Biotech Conferences: Press Coverage, Scientist: Career considerations, Technology Capital Expenses, Uncategorized, Venture Capital, tagged angel investors, Aviva Lev-Ari, bioinvestment, biotech incubator, biotech startup, Biotechnology and Pharmaceuticals, competetive intelligence, Conditions and Diseases, crowd-funding, diabetes foundaion, Drug discovery, Food and Drug Administration, health, Health Care Delivery, health care spending, Innovation, Intellectual property, Medicare, medicare costs, Patent portfolio, patents, pharmacy benefit managers, philadelphia, Princeton University, Reimbursement, research, science funding, startup, United States Patent and Trademark Office, Venture capital on March 11, 2015| Leave a Comment »

Protecting Your Biotech IP and Market Strategy: Notes from Life Sciences Collaborative 2015 Meeting Reporter: Stephen J. Williams, PhD WordCloud Image Produced by Adam Tubman Achievement Beyond Regulatory Approval – Design for Commercial Success Stephen J. Williams, Ph.D.: Reporter The Mid-Atlantic group Life Sciences Collaborative, a select group of industry veterans and executives from […]

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The Significant Burden of Childhood Malnutrition and Stunting

Posted in Blindness, Cell Biology, Childhood malnutrition, Fat soluble vitamins, Micronutrients, Nutrition, Protein-energy malnutrition, tagged children's health, Kwashiorkor, muscle wasting, Nutrition, Protein-energy malnutrition, Stunting on October 24, 2015| Leave a Comment »

The Significant Burden of Childhood Malnutrition and Stunting Curator: Larry H. Bernstein, MD, FCAP Micronutrients Quite a few trace elements or micronutrients—vitamins and minerals—are important for health. Three very important micronutrient deficiencies in terms of health consequences for poor people in developing countries are: Iron In developing countries every second pregnant woman and about 40% […]

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Keeping Stem Cells in Check

Posted in Cell Biology, Curation, Developmental biology, Innovations, Innovations in Neurophysiology & Neuropsychology, Intellectual Property, Investment in Technological Breakthrough, Neurological Diseases, Neuroscience, Regenerative Biology and Medicine, tagged Broad Institute, regenerative medicine, stem cell biology, USC on November 5, 2015| Leave a Comment »

Keeping Stem Cells in Check Larry H. Bernstein, MD, FCAP, Curator LPBI Researchers track gene that keeps stem cells in check “Prkci” influences whether stem cells self-renew or differentiate into more specialized cell types http://news.usc.edu/88168/researchers-probe-a-gene-that-keeps-stem-cells-in-check/ http://news.usc.edu/files/2015/10/nestin_tuj_ratreated_escells_WEB-824×549.jpg When it comes to stem cells, too much of a good thing isn’t wonderful: Producing too […]

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Radiation and Chemotherapy Therapy: The Pharmacological Risk for Developing Cardiovascular Disease

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Frontiers in Cardiology and Cardiovascular Disorders on January 8, 2014| Leave a Comment »

Radiation and Chemotherapy Therapy: The Pharmacological Risk for Developing Cardiovascular Disease Reporter: Aviva Lev-Ari, PhD, RN Cancer treatments may harm the heart August 2012 Doctors strive to prevent the cure for one disease from causing another. Cancer treatment can be the proverbial double-edged sword. Radiation therapy and chemotherapy are increasing the number of people who […]

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DNA mutagenesis and DNA repair

Posted in Genome Biology, tagged Cancer - General, DNA repair, Mutagenesis, radiation damage on September 5, 2015| Leave a Comment »

DNA mutagenesis and DNA repair Larry H. Bernstein, MD, FCAP, Curator Leaders in Pharmaceutical Intelligence – Series E (2; 2.11) Evelyn M. Witkin, born Evelyn Maisel is an American geneticist who was awarded the National Medal of Science for her work on DNA mutagenesis and DNA repair. She earned her Ph.D. in 1947 with Theodosius […]

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Genes, proteomes, and their interaction

Posted in Alzheimer's Disease, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Cerebrovascular and Neurodegenerative Diseases, Chemical Biology and its relations to Metabolic Disease, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Enzyme Induction, Evolutionary cognition, Gene Regulation, Genome Biology, Genomic Expression, Human Immune System in Health and in Disease, Ionic Transporters Na+, Metabolomics, Placenta, Proteomics, Reproductive Andrology, Embryology, Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics, Signaling, Technology Advance Assessment of, Transcriptomics, tagged genomics, Na-transporter, PARC, Proteomics, signaling pathways, thyroid hormone, transcrition on July 28, 2014| Leave a Comment »

Larry H. Bernstein, MD, FCAP, Author and Curator http://pharmaceuticalintelligence.com/7/17/2014/Genes, proteomes, and their interaction This is the third discussion of a several part series leading from the genome, to protein synthesis (1), posttranslational modification of proteins (2), examples of protein effects on metabolism and signaling pathways (3), and leading to disruption of signaling pathways in […]

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RAbD Biotech Presents at 1st Pitch Life Sciences-Philadelphia

Posted in Advanced Drug Manufacturing Technology, Bio Instrumentation in Experimental Life Sciences Research, Bioengineering & reverse engineering design, Biological Networks, BioSimilars, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Commercialization, Computational Biology/Systems and Bioinformatics, Conference Coverage with Social Media, Disease Biology, Drug Delivery Platform Technology, FDA, Health Economics and Outcomes Research, Innovations, Pharmaceutical Drug Discovery, Pharmaceutical Industry Competitive Intelligence, Pharmaceutical R&D Investment, Scientific & Biotech Conferences: Press Coverage, tagged Antibodies, bioangel, bioinvestment, Biomimic systems, Biosimilar, biosimilars, biotech startup, Biotechnology, computational algorithms, computational biology, Fox Chase Cancer Center, mimetic, ovarian cancer, rational drug design on September 17, 2014| Leave a Comment »

RAbD Biotech Presents at 1st Pitch Life Sciences-Philadelphia-September 16, 2014 Reporter: Stephen J. Williams, PhD UPDATE 12/09/2022 The following is background material of RAbD technology, bispecific antibodies: Current landscape and future directions of bispecific antibodies in cancer immunotherapy Jing Wei1†, Yueyao Yang2†, Gang Wang2 and Ming Liu1* 1Gastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, China 2National […]