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Immune System Stimulants: Articles of Note @pharmaceuticalintelligence.com Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN   New Approaches to Immunotherapy   New Class of Immune System Stimulants: Cyclic Di-Nucleotides (CDN): Shrink Tumors and bolster Vaccines, re-arm the Immune System’s Natural Killer Cells, which attack Cancer Cells and Virus-infected Cells Three Methods for […]

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Oncolytic Virus Immuno-Therapy: New Approach for a New Class of Immunotherapy Drugs Curator: Larry H. Bernstein, MD, FCAP   Oncolytic viruses represent a promising novel immunotherapy strategy, which may be optimally combined with existing therapeutic modalities Oncolytic viruses: a novel form of immunotherapy Robin J Prestwich, Kevin J Harrington,  Hardev S Pandha, Richard G Vile, Alan […]

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TAVR with Sapien 3: combined all-cause death & disabling stroke rate was 8.4% and 16.6% for the surgery arm Reporter: Aviva Lev-Ari, PhD, RN   UPDATED on 6/24/2020 Sapien 3 TAVR On Par with Surgery at 5 Years — Differences observed in stroke and pacemaker rates by Nicole Lou, Staff Writer, MedPage Today June 21, 2020   […]

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Schizophrenia genomics Larry H. Bernstein, MD, FCAP, Curator LPBI   Histone Methylation at H3K9; Evidence for a Restrictive Epigenome in Schizophrenia Kayla A. Chase,1David P. Gavin,1Alessandro Guidotti,1 and Rajiv P. Sharma1 Schizophr Res. 2013 Sep; 149(0): 15–20.      doi:  10.1016/j.schres.2013.06.021 Epigenetic changes are stable and long-lasting chromatin modifications that regulate genomewide and local gene activity. […]

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UPDATED – Status “Interference — Initial memorandum” – CRISPR/Cas9 – The Biotech Patent Fight of the Century: UC, Berkeley and Broad Institute @MIT Reporter: Aviva Lev-Ari, PhD, RN   UPDATED on 6/30/2019 Patent office renews dispute over patent rights to CRISPR-Cas9 By Public Affairs, UC Berkeley| JUNE 25, 2019   Schematic representation of the CRISPR-Cas9 system. The Cas9 […]

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Perspectives on Anti-metastatic Effects in Cancer Research 2015 Curator: Larry H. Bernstein, MD, FCAP   Combining Kinetic Ligand Binding and 3D Tumor Invasion Technologies to Assess Drug Residence Time and Anti-metastatic Effects of CXCR4 Inhibitors Application Note 3D Cell Culture, ADME/Tox, Cell Imaging, Cell-Based Assays BioTek Instruments, Inc. P.O. Box 998, Highland Park, Winooski, Vermont […]

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Are CXCR4 Antagonists Making a Comeback in Cancer Chemotherapy? Reporter: Stephen J. Williams, Ph.D. Biospace News reported that Massachusetts based X4 Pharmaceuticals is using $34B to launch two clinical trials on its CXCR4 inhibitor X4P-001 in refractory clear cell renal cell carcinoma and refractory epithelial ovarian cancer. The full report is below: X4 Pharma Uses […]

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Serum Folate and Homocysteine, Mood Disorders, and Aging Larry H. Bernstein, MD, FCAP, Curator LPBI   Dietary Folate and the Risk of Depression in Finnish MiddleAged Men Tolmunen T, et al. PSYCHOTHER AND PSYCHOSOM · OCT 2004; 73:334-339    DOI: http://dx.doi.org:/10.1159/000080385   Serum Folate, Vitamin B-12, and Homocysteine and Their Association With Depressive Symptoms Among […]

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Excess Eating, Overweight, and Diabetic Larry H Bernstein, MD, FCAP, Curator LPBI   You Did NOT Eat Your Way to Diabetes! http://www.phlaunt.com/diabetes/14046739.php   The myth that diabetes is caused by overeating also hurts the one out of five people who are not overweight when they contract Type 2 Diabetes. Because doctors only think “Diabetes” when […]

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Quiagen in Molecular Diagnostics Larry H. Bernstein, MD, FCAP, Curator LPBI   QIAGEN Releases GeneReader for Clinical Sequencing in Cancer By Aaron Krol http://www.bio-itworld.com/2015/11/9/qiagen-releases-genereader-clinical-sequencing-cancer.html   November 9, 2015 | QIAGEN’s GeneReader DNA sequencing system was finally unveiled last week in Austin, Tex., at the annual meeting of the Association for Molecular Pathology. The company had […]

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