Posted in Cardiac and Cardiovascular Surgical Procedures, Limb ischemia, Peripheral Arterial Disease & Peripheral Vascular Surgery on August 8, 2015| Leave a Comment »
More amputations, less revascularization among blacks with critical limb ischemia
Reporter: Aviva Lev-Ari, PhD, RN
Blacks with critical limb ischemia are disproportionately more likely to undergo limb amputation, according to a report presented at the Society for Vascular Surgery Annual Meeting. Researchers fro…
Sourced through Scoop.it from: diabeticfootonline.com
See on Scoop.it – Cardiovascular and vascular imaging
Posted in Academic Publishing, Biological Networks, Bone Disease and Musculoskeletal Disease, Ca2+ triggered activation, Calcium, Calcium Signaling, Cancer and Current Therapeutics, Cancer Prevention: Research & Programs, Cardiac & Vascular Repair Tools Subsegment, Cell Biology, Diabetes Mellitus, Drug Toxicity, Endocrine Diseases, Health Economics and Outcomes Research, Peripheral Arterial Disease & Peripheral Vascular Surgery, Population Health Management, tagged Calcium in biology, Cancer - General, Conditions and Diseases, Essential nutrient, health, Heart disease, medical information, nutirition, Nutritional Supplements, research, science, scientific reporting, toxicity, vitamin D on April 14, 2015| Leave a Comment »
Reporter: Stephen J. Williams, Ph.D.
A recent posting by a group called the Vitamin D Council (and put on this site) had referred to, and misquoted, the Mayo Clinic site on the role of vitamin D on various diseases. At first I was curious if this was actually reported on the Mayo site on claims of prevention of various cancers (as results from retrospective studies had been conflicting) and originally had made some strong comments. From comments made from this post I do agree that there is strong evidence about vitamin D supplementation for the prevention of rickets but as Mayo reviewed claims about vitamin D supplementation and prevention of certain diseases such as cancers and heart disease may not be as strong as some suggest. My main concern was : is the clinical evidence strong enough for the role of vitamin D supplementation in a wide array of diseases and did Mayo make the claims as suggested in some media reports? Actually Mayo does a very thorough job of determining the clinical evidence and the focus of vitamins and cancer risk will be a point of further discussion.
After consulting the Mayo clinic website it appears that the Vitamin D Council site had indeed misquoted and misrepresented the medical information contained within the Mayo Clinic website.
The site had made numerous claims on role of vitamin D3 (cholecalciferol) in numerous diseases; making it appear there were definitive links between low vitamin D3 and risk of hypertension, cancer, depression and diabetes.
Vitamin D refers to a group of fat-soluble secosteroids responsible for enhancing intestinal absorption of calcium, iron, magnesium, phosphate and zinc. In humans, the most important compounds in this group are vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol).[1] Cholecalciferol and ergocalciferol can be ingested from the diet and from supplements.[1][2][3] Very few foods contain vitamin D; synthesis of vitamin D (specifically cholecalciferol) in the skin is the major natural sources of the vitamin. Dermal synthesis of vitamin D from cholesterol is dependent on sun exposure (specifically UVB radiation).Vitamin D has a significant role in calcium homeostasis and metabolism. Its discovery was due to effort to find the dietary substance lacking in rickets (the childhood form of osteomalacia).[4]
also from Widipedia on Vitamin D toxicity
Vitamin D toxicity
Vitamin D toxicity is rare.[20] It is caused by supplementing with high doses of vitamin D rather than sunlight. The threshold for vitamin D toxicity has not been established; however, the tolerable upper intake level (UL), according to some research, is 4,000 IU/day for ages 9–71.[7] Whereas another research concludes that in healthy adults, sustained intake of more than 1250 μg/day (50,000 IU) can produce overt toxicity after several months and can increase serum 25-hydroxyvitamin D levels to 150 ng/ml and greater;[20][56] those with certain medical conditions, such as primary hyperparathyroidism,[57] are far more sensitive to vitamin D and develop hypercalcemia in response to any increase in vitamin D nutrition, while maternal hypercalcemia during pregnancy may increase fetal sensitivity to effects of vitamin D and lead to a syndrome of mental retardation and facial deformities.[57][58]
After being commissioned by the Canadian and American governments, the Institute of Medicine (IOM) as of 30 November 2010, has increased the tolerable upper limit (UL) to 2,500 IU per day for ages 1–3 years, 3,000 IU per day for ages 4–8 years and 4,000 IU per day for ages 9–71+ years (including pregnant or lactating women).[7]
Published cases of toxicity involving hypercalcemia in which the vitamin D dose and the 25-hydroxy-vitamin D levels are known all involve an intake of ≥40,000 IU (1,000 μg) per day.[57] Recommending supplementation, when those supposedly in need of it are labeled healthy, has proved contentious, and doubt exists concerning long-term effects of attaining and maintaining high serum 25(OH)D by supplementation.[61]
From the Mayo Clinic Website on Vitamin D
The Mayo Clinic has done a wonderful job curating the uses and proposed uses of vitamin D for various diseases and rates the evidence using a grading system A-F (as shown below):
A STRONG scientific evidence FOR THIS USE
B GOOD scientific evidence FOR THIS USE
C UNCLEAR scientific evidence for this use
D Fair scientific evidence AGAINST THIS USE (it may not work)
F Strong scientific evidence AGAINST THIS USE (it likely does not work)
Mayo has information for other natural products as well. As described below (and on the Mayo site here) most of the supposed evidence fails their criteria for a strong clinical link between diseases such as heart disease, hypertension, cancer and vitamin D (either parental or D3) levels.
The important take-home from the Mayo site is that there is strong evidence for the use of vitamin D in diseases related to the known mechanism of vitamin D such as low serum phosphate either due to kidney disease (Fanconi syndrome) or familial hypophosphatemia or in diseases surrounding bone metabolism like osteomalacia, rickets, dental cavities and even as a treatment for psoriasis or underactive parathyroid.
However most indications like hypertension, stroke, cancer prevention or treatment (other than supportive therapy for low vitamin D levels) get a poor grade (C or D) for clinical correlation from Mayo Clinic.
Below is taken from the Mayo Site:
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
| Evidence grade | Condition to which grade level applies |
| A |
Deficiency (phosphate)Familial hypophosphatemia is a rare, inherited condition in which there are low blood levels of phosphate and problems with vitamin D metabolism. It is a form of rickets. Taking calcitriol or dihydrotachysterol by mouth along with phosphate supplements is effective for treating bone disorders in people with this disease. Those with this disorder should be monitored by a medical professional. |
| A |
Kidney disease (causing low phosphate levels)Fanconi syndrome is a kidney disease in which nutrients, including phosphate, are lost in the urine instead of being reabsorbed by the body. Taking ergocalciferol by mouth is effective for treating low phosphate levels caused by Fanconi syndrome. |
| A |
Osteomalacia (bone softening in adults)Adults who have severe vitamin D deficiency may experience bone pain and softness, as well as muscle weakness. Osteomalacia may be found among the following people: those who are elderly and have diets low in vitamin D; those with problems absorbing vitamin D; those without enough sun exposure; those who undergo stomach or intestine surgery; those with bone disease caused by aluminum; those with chronic liver disease; or those with bone disease associated with kidney problems. Treatment for osteomalacia depends on the cause of the disease and often includes pain control and surgery, as well as vitamin D and phosphate-binding agents. |
| A |
Psoriasis (disorder causing skin redness and irritation)Many different approaches are used to treat psoriasis, including light therapy, stress reduction, moisturizers, or salicylic acid. For more severe cases, calcipotriene (Dovonex®), a man-made substance similar to vitamin D3, may help control skin cell growth. This agent is a first-line treatment for mild-to-moderate psoriasis. Calcipotriene is also available with betamethasone and may be safe for up to one year. Vitamin D3 (tacalcitol) ointment or high doses of becocalcidiol applied to the skin are also thought to be safe and well-tolerated. |
| A |
Rickets (bone weakening in children)Rickets may develop in children who have vitamin D deficiency caused by a diet low in vitamin D, a lack of sunlight, or both. Babies fed only breast milk (without supplemental vitamin D) may also develop rickets. Ergocalciferol or cholecalciferol is effective for treating rickets caused by vitamin D deficiency. Calcitriol should be used in those with kidney failure. Treatment should be under medical supervision. |
| A |
Thyroid conditions (causing low calcium levels)Low levels of parathyroid hormone may occur after surgery to remove the parathyroid glands. Taking high doses of dihydrotachysterol, calcitriol, or ergocalciferol by mouth, with or without calcium, may help increase calcium levels in people with this type of thyroid problem. Increasing calcium intake, with or without vitamin D, may reduce the risk of underactive parathyroid glands. |
| A |
Thyroid conditions (due to low vitamin D levels)Some people may have overactive parathyroid glands due to low levels of vitamin D, and vitamin D is the first treatment for this disorder. For people who have overactive parathyroid glands due to other causes, surgery to remove the glands is often recommended. Studies suggest that vitamin D may help reduce the risk of further thyroid problems after undergoing partial or total removal of the parathyroid glands. |
| A |
Vitamin D deficiencyVitamin D deficiency is associated with many conditions, including bone loss, kidney disease, lung disorders, diabetes, stomach and intestine problems, and heart disease. Vitamin D supplementation has been found to help prevent or treat vitamin D deficiency. |
| B |
Dental cavitiesMuch evidence has shown that vitamin D helps prevent cavities; however, more high-quality research is needed to further support this finding. |
| B |
Renal osteodystrophy (bone problems due to chronic kidney failure)Renal osteodystrophy refers to the bone problems that occur in people with chronic kidney failure. Calcifediol or ergocalciferol taken by mouth may help prevent this condition in people with chronic kidney failure who are undergoing treatment. |
| C |
Autoimmune diseasesVitamin D may reduce inflammation and help prevent autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and Crohn’s disease. However, further high-quality research is needed to confirm these results. |
| C |
Bone density (children)Vitamin D improves bone density in children who are vitamin D deficient. However, results are unclear and more research is needed. |
| C |
Bone diseases (kidney disease or kidney transplant)Vitamin D has been studied for people with chronic kidney disease. The use of substances similar to vitamin D has been found to increase bone density in people with kidney disease. The effect of vitamin D itself is unclear. Further research is needed before conclusions can be made. |
| C |
Cancer prevention (breast, colorectal, prostate, other)Many studies have looked at the effects of vitamin D on cancer. Positive results have been reported with the use of vitamin D alone or with calcium. Vitamin D intake with or without calcium has been studied for colorectal, cervical, breast, and prostate cancer. A reduced risk of colorectal cancer has been shown with vitamin D supplementation. However, there is a lack of consistent or strong evidence. Further study is needed. |
| C |
Fibromyalgia (long-term, body-wide pain)Vitamin D has been studied for the treatment of fibromyalgia, but evidence is lacking in support of its effectiveness. Further study is needed. |
| C |
Fractures (prevention)Conflicting results have been found on the use of vitamin D for fracture prevention. The combination of alfacalcidol and alendronate has been found to reduce the risk of falls and fractures. However, further high-quality research is needed before firm conclusions can be made. |
| C |
Hepatic osteodystrophy (bone disease in people with liver disease)Metabolic bone disease is common among people with chronic liver disease, and osteoporosis accounts for the majority of cases. Varying degrees of poor calcium absorption may occur in people with chronic liver disease due to malnutrition and vitamin D deficiency. Vitamin D taken by mouth or injected may play a role in the management of this condition. |
| C |
High blood pressureLow levels of vitamin D may be linked to high blood pressure. Blood pressure is often higher during the winter season, at a further distance from the equator, and in people with dark skin pigmentation. However, the evidence is unclear. More research is needed in this area. People who have high blood pressure should be managed by a medical professional. |
| C |
Immune functionEarly research suggests that vitamin D and similar compounds, such as alfacalcidol, may impact immune function. Vitamin D added to standard therapy may benefit people with infectious disease. More studies are needed to confirm these results. |
| C |
Seasonal affective disorder (SAD)SAD is a form of depression that occurs during the winter months, possibly due to reduced exposure to sunlight. In one study, vitamin D was found to be better than light therapy in the treatment of SAD. Further studies are necessary to confirm these findings. |
| C |
StrokeHigher levels of vitamin D may decrease the risk of stroke. However, further study is needed to confirm the use of vitamin D for this condition. |
| C |
Type 1 diabetesSome studies suggest that vitamin D may help prevent the development of type 1 diabetes. However, there is a lack of strong evidence to support this finding. |
| C |
Type 2 diabetesVitamin D has mixed effects on blood sugar and insulin sensitivity. It is often studied in combination with calcium. Further research is needed to confirm these results. |
| D |
Cancer treatment (prostate)Evidence suggests a lack of effect of vitamin D as a part of cancer treatment for prostate cancer. Further study is needed using other formulations of vitamin D and other types of cancer. |
| D |
Heart diseaseVitamin D is recognized as being important for heart health. Overall, research is not consistent, and some studies have found negative effects of vitamin D on heart health. More high-quality research is needed to make a firm conclusion. |
| D |
High cholesterolMany studies have looked at the effects of vitamin D alone or in combination with other agents for high cholesterol, but results are inconsistent. Some negative effects have been reported. More research is needed on the use of vitamin D alone or in combination with calcium. |
Posted in Cardiac and Cardiovascular Surgical Procedures, Limb ischemia, Peripheral Arterial Disease & Peripheral Vascular Surgery on March 4, 2015| Leave a Comment »
Endovascular therapy for critical limb ischemia: Expert Review of Cardiovascular Therapy, Ahead of Print. (Sou…
Source: informahealthcare.com
Posted in Cardiac and Cardiovascular Surgical Procedures, Electrophysiology, Frontiers in Cardiology and Cardiovascular Disorders, Origins of Cardiovascular Disease, Peripheral Arterial Disease & Peripheral Vascular Surgery on February 16, 2015| Leave a Comment »
Reporter: Aviva Lev-Ari, PhD, RN
Endovascular therapy for acute ischemic stroke increased modestly in use before dropping last year, analysis of Get With The Guidelines-Stroke hospitals showed. A big boost is expected after the recent spate of positive trials.
The American Heart Association is teaming up with Medtronic on a recurrent cryptogenic stroke reduction initiative.
In related news, Medtronic featured real-world use of its Reveal LINQ insertable cardiac monitor for atrial fibrillation detection in cryptogenic stroke patients at the AHA’s International Stroke Conference.
Venous thromboembolism prophylaxis is recommended for all stroke patients with weakness in new recommendations released at the ISC from the nonprofit Physician-Patient Alliance for Health and Safety.
CardioBreak is a guide to what’s new and interesting on the Web for cardiologists and other healthcare professionals with an interest in cardiovascular disease, powered by the MedPage Today community. Got a tip? Send it to us: c.phend@medpagetoday.com.
SOURCE
Other articles published in this Open Access Online Scientific Journal include the following:
Stroke – Ten Big Factors, Heart Rate No Predictor of Second Stroke
Posted in Frontiers in Cardiology and Cardiovascular Disorders, Limb ischemia, Vascular Diseases on December 15, 2014| Leave a Comment »
Reporter: Aviva Lev-Ari, PhD, RN
Describes the definition of critical limb ischemia, main Trials over the last 2 years and different techniques for critical limb ischemia rescue.- Name of the …
Source: es.slideshare.net
Posted in Abdominal Aorta, Academic Publishing, Artificial Heart, BiVAD, CABG, Cancer Surgery of the Heart, Cardiac & Vascular Repair Tools Subsegment, Cardiac and Cardiovascular Surgical Procedures, Cardiovascular Pharmacogenomics, Carotid Artery, Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Pulmonary Arterial Hypertension (PAH), Clinical Diagnostics, Coagulation Therapy and Internal Bleeding, Conference Coverage with Social Media, CT, Curation, Curation methodology, De novo synthesis, Dialectic, Discovery process, Evolutionary cognition, Exec Compensation in the Cardiac & Vascular Repair Tools Subsegment, Experimental validation, Explanatory, Frontiers in Cardiology and Cardiovascular Disorders, Heart Transplant, Heart-Lung Transplant, Historical relevance, Mechanical Assist Devices: LVAD, Mitral Valve: Repair and Replacement, PCI, Peripheral Arterial Disease & Peripheral Vascular Surgery, Renal Denervation, RVAD, TAVI vs Open Heart Surgery, Technology Advance Assessment of, Thoracic Aorta, tagged Aviva Lev-Ari, Biology, Cardiovascular disease, Cardiovascular Disorders, ebook, health, Heart disease, Heart Failure, Hypertension, Larry H. Bernstein, medical breakthrough, medical education, nitric oxide, Personalized medicine, research on September 27, 2014| Leave a Comment »
Reporter: Aviva Lev-Ari, PhD, RN
Volume II can be found at http://pharmaceuticalintelligence.com/biomed-e-books/series-a-e-books-on-cardiovascular-diseases/volume-two-cardiovascular-original-research-cases-in-methodology-design-for-content-co-curation/
Volume III can be found at http://pharmaceuticalintelligence.com/biomed-e-books/series-a-e-books-on-cardiovascular-diseases/volume-three-etiologies-of-cardiovascular-diseases-epigenetics-genetics-genomics/
Volume IV can be found at http://pharmaceuticalintelligence.com/biomed-e-books/series-a-e-books-on-cardiovascular-diseases/volume-four-therapeutic-promise-cvd-regenerative-translational-medicine/
http://www.sachsforum.com/basel14/index.html
ON TWITTER Follow atPosted in Cardiac and Cardiovascular Surgical Procedures, PCI, Peripheral Arterial Disease & Peripheral Vascular Surgery on September 26, 2014| Leave a Comment »
ESVS e-Learning sur Twitter : “The Transatlantic debate started: surgery vs. percutaneous intervention for critical limb ischemia
Reporter: Aviva Lev-Ari, PhD, RN
The Transatlantic debate started: surgery vs. percutaneous intervention for critical limb ischemia #ESVS2014
Source: twitter.com
Posted in Cardiac & Vascular Repair Tools Subsegment, Cardiac and Cardiovascular Surgical Procedures, CE Mark & Global Regulatory Affairs: process management and strategic planning - GCP, Ecosystems & Industrial Concentration in the Medical Device Sector, FDA, GLP, ISO 14155, Medical Devices R&D Investment, PCI, Peripheral Arterial Disease & Peripheral Vascular Surgery on August 22, 2014| Leave a Comment »
Reporter: Aviva Lev-Ari, PhD, RN
Covidien Acquires Reverse Medical Corporation
Fri, 08/22/2014 – 9:12am
Business Wire
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Generates Opportunity to Leverage Existing Vascular Technologies and Customer Relationships to Drive Increased Market Penetration
Covidien plc has announced it has acquired Reverse Medical Corporation, a privately held medical device company focused on expanding the management of vascular disease. Financial terms of the transaction were not disclosed.
“Covidien is focused on technologies that deliver improved patient care through clinically relevant and economically valuable solutions,” said Brett Wall, president, Neurovascular, Covidien. “The acquisition of Reverse Medical is complementary to our existing portfolio and will allow us to leverage existing vascular technologies to compete in the worldwide vascular embolization market, which is growing at a double digit rate.”
Covidien will report the Reverse Medical business as part of its Neurovascular product line in the Medical Devices segment. Annualized dilution is not expected to be material.
Reverse Medical is currently commercializing its vascular embolization plugs, MVP Micro Vascular Plug System and UNO™ Neurovascular Embolization System. MVP and UNO are self-expanding vessel occlusion devices, which close blood vessels for vascular embolization. A number of clinical applications require occlusion of the vasculature to rapidly, effectively and safely provide blood flow cessation.
Other Reverse Medical products include ReVerse Microcatheter for device delivery and Barrel™ Vascular Reconstruction Device (VRD), a self-expandable bifurcation aneurysm bridging device. All the devices have received CE Mark approval and are commercially available in Europe. Additionally, MVP-3 and MVP-5 are 510(k) cleared in the U.S.
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