For UPDATES on this Cardinal Conference and for REGISTRATION, go to

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005559/

Posted in Biological Engineering, Biomarkers & Medical Diagnostics, Cancer Prevention: Research & Programs, Disease Biology, Drug Delivery Platform Technology, Great Discoveries, Innovations, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound, Physics, tagged brain, Focused Ultrasound, MRI, surgery, tumor, uterine fibroids on November 15, 2018| Leave a Comment »

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

MRI-guided focused ultrasound (MRgFUS) surgery is a noninvasive thermal ablation method that uses magnetic resonance imaging (MRI) for target definition, treatment planning, and closed-loop control of energy deposition. Ultrasound is a form of energy that can pass through skin, muscle, fat and other soft tissue so no incisions or inserted probes are needed. High intensity focused ultrasound (HIFU) pinpoints a small target and provides a therapeutic effect by raising the temperature high enough to destroy the target with no damage to surrounding tissue. Integrating FUS and MRI as a therapy delivery system allows physicians to localize, target, and monitor in real time, and thus to ablate targeted tissue without damaging normal structures. This precision makes MRgFUS an attractive alternative to surgical resection or radiation therapy of benign and malignant tumors.

Hypothalamic hamartoma is a rare, benign (non-cancerous) brain tumor that can cause different types of seizures, cognitive problems or other symptoms. While the exact number of people with hypothalamic hamartomas is not known, it is estimated to occur in 1 out of 200,000 children and teenagers worldwide. In one such case at Nicklaus Children’s Brain Institute, USA the patient was able to return home the following day after FUS, resume normal regular activities and remained seizure free. Patients undergoing standard brain surgery to remove similar tumors are typically hospitalized for several days, require sutures, and are at risk of bleeding and infections.

MRgFUS is already approved for the treatment of uterine fibroids. It is in ongoing clinical trials for the treatment of breast, liver, prostate, and brain cancer and for the palliation of pain in bone metastasis. In addition to thermal ablation, FUS, with or without the use of microbubbles, can temporarily change vascular or cell membrane permeability and release or activate various compounds for targeted drug delivery or gene therapy. A disruptive technology, MRgFUS provides new therapeutic approaches and may cause major changes in patient management and several medical disciplines.

References:

https://www.mayoclinic.org/tests-procedures/focused-ultrasound-surgery/about/pac-20384707

https://www.mdtmag.com/news/2017/04/nicklaus-childrens-hospital-performs-worlds-first-focused-ultrasound-surgery-hypothalamic-hamartoma?et_cid=5922034&et_rid=765461457&location=top&et_cid=5922034&et_rid=765461457&linkid=https%3a%2f%2fwww.mdtmag.com%2fnews%2f2017%2f04%2fnicklaus-childrens-hospital-performs-worlds-first-focused-ultrasound-surgery-hypothalamic-hamartoma%3fet_cid%3d5922034%26et_rid%3d%%subscriberid%%%26location%3dtop

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097768/

https://stanfordhealthcare.org/medical-treatments/m/mr-guided-focused-ultrasound.html

Posted in Drug Carrier Design, Drug Delivery Platform Technology, Medical Devices R&D and Inventions, Nanotechnology for Drug Delivery, Physics, tagged dielectric elastomer, lens, metalens, nanostructures, optical on September 8, 2018| Leave a Comment »

Reporter: Irina Robu, PhD

Metalens, flat surface that use nanostructures to focus light promise to transform optics by replacing the bulky, curved lenses presently used in optical devices with a simple, flat surface.

Scientists at the Harvard John A. Paulson School of Engineering and Applied Sciences designed metalens who are mainly focused on light and minimizes spherical aberrations through a dense pattern of nanostructures, since the information density in each lens will be high due to nanostructures being small.

According to Federico Capasso, “This demonstrates the feasibility of embedded optical zoom and auto focus for a wide range of applications, including cell phone cameras, eyeglasses, and virtual and augmented reality hardware. It also shows the possibility of future optical microscopes, which operate fully electronically and can correct many aberrations simultaneously.”

However, when scientists tried to scale up the lens, the file size of the design alone would balloon up to gigabytes or even terabytes. And as a result, create a new algorithm in order to shrivel the file size to make the metalens flawless with the innovation currently used to create integrated circuits. Afterward, scientists follow the large metalens to an artificial muscle without conceding its ability to focus light. In the human eye, the lens is enclosed by ciliary muscle, which stretches or compresses the lens, changing its shape to adjust its focal length. Scientists at that moment choose a thin, transparent dielectric elastomer with low to attach to the lens.

Within the experiment, when the voltage is applied to elastomers, it stretches, the position of nanopillars on the surface of the lens shift. The scientists as a result show that the lens can focus instantaneous, control abnormalities triggered by astigmatisms, and achieve image shift. Since the adaptive metalens is flat, you can correct those deviations and assimilate diverse optical capabilities onto a single plane of control.

SOURCE

Breakthroughs seen in artificial eye and muscle technology

http://med.stanford.edu/news/all-news/2018/07/magnetized-wire-could-be-used-to-detect-cancer-in-people.html

Posted in Cancer - General, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Drug Delivery Platform Technology, Tissue Engineering, tagged Cancer, cancer blood tests, cancerous cells, genetics, magnetic wire, tumor cells on September 2, 2018| Leave a Comment »

Reporter: Irina Robu, PhD

Stanford University scientists developed a magnetic wire which doctors can use to detect cancer before symptoms are detected in patients. The device is threaded into a vein, screens for the disease by attracting scarce and hard to capture tumor cells just like a magnet. The wire would be predominantly valuable to detect ‘silent killers’ such as pancreatic, ovarian and kidney cancer where symptoms only seem in the late stages when it has spread too far to treat. The magnetic wire can save thousands of lives by catching the disease at a time when drugs would be effective. Cells that have broken off a tumor to wander the bloodstream easily can assist as cancer biomarkers signaling the presence of the disease.

Dr. Gambhir’s team published the results in Nature Biomedical Engineering which described how using a wire that has magnetic nano-particles engineered to stick to cancerous cells. The original experiment is on pigs, which are structurally alike to humans and suffer from the same genetic malfunctions that cause cancer. The wire captured 10 to 80 times more tumor cells and was placed in a vein near the pig’s ear which can be removed from and the cells can be used for analysis. In real standings it chosen up 500 to 5,000 more cancerous cells than normal blood samples.

The circulating tumor cells were magnetized with nanoparticles containing an antibody that latch onto them. When attached, the cell carries the tiny magnet around with it and flows past the wire to veer from its regular path in the bloodstream and stick to the wire. Professor Gambhir hopes that this approach will enrich detection capability and give insight how circulating tumor cells are and how early on they exist once the cancer is present. Once the technology is accepted for humans, the goal is to mature it into a multi-pronged tool that will increase detection, diagnosis, treatment and evaluation of cancer therapy.

It can also be used to gather genetic information about tumors located in places from where it’s hard to take biopsies.

Source

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198596

Posted in Biological Engineering, Cancer - General, Childhood cancer, Drug Carrier Design, Drug Delivery Platform Technology, Regenerative Biology and Medicine, Stem Cells for Regenerative Medicine, tagged Cell therapy, cytotoxic agent, genetic engineering, medulloblastoma, skin cells on September 2, 2018| Leave a Comment »

Reporter: Irina Robu, PhD

Medulloblastoma, common brain cancer in children has been very difficult to treat therapeutically with traditional interventions which relies on surgical techniques to remove the bulk of the cancerous tissue. The researchers seen the need for novel treatments of medulloblastomas that have recurred, as well as for treatments that are less toxic overall. For this reason, data from University of North Carolina (UNC) Lineberger Comprehensive Cancer Center and Eshelman School of Pharmacy published a study in PLOS named “Intra-cavity stem cell therapy inhibits tumor progression in a novel murine model of medulloblastoma surgical resection”, validates how cancer-hunting stem cells can track down and deliver a drug to terminate medulloblastoma cells hiding after surgery.

The technology in the research is an extension of a discovery that won researchers a Nobel Prize in 2012 and showed they could transform skin cells into stem cells. The research team started by reprogramming skin cells into stem cells and genetically engineered them to manufacture a substance that becomes toxic to other cells when exposed to another drug. Inserting the drug carries the stem cells into the brain of laboratory models after surgery decreased the size of tumors by 15 times and extended median survival in mice by 133%.

In this study, the scientists indicated they could shrink tumors in murine models of medulloblastoma, hence extending the rodents life. The approach holds promise for reducing side effects and helping more children with medulloblastoma. Amazingly the researchers also developed a laboratory model of medulloblastoma that allowed them to simulate the way standard care is currently delivered—surgery followed by drug therapy. Using this model, they discovered that after surgically removing a tumor, the cancer cells that remained grew faster.

According to the study investigator, Shawn Hingtgen, PhD, the cells are like a FedEx truck that will deliver cytotoxic agents directly into the tumor to a particular location. In earlier studies, Dr. Hingtgen and his colleagues showed that they could flip skin cells into stem cells that hunt and transport cancer-killing drugs to glioblastoma, the deadliest malignant brain tumor in adults.

Medulloblastoma is cancer that happens mostly in kids between ages of three and eight, and while current therapy has changed survival pretty dramatically, it can still be pretty toxic. The ability to use a patient’s own cells to target the tumor directly would be “the holy grail” of therapy, the investigators trust it could hold capacity for other rare, and sometimes fatal, brain cancer types that occur in children as well.

Source

Press Conference: Exosome-based Drug Delivery Systems

Posted in Conference Coverage with Social Media, Drug Delivery Platform Technology, Exosomes: Natural Carriers for siRNA Delivery on June 5, 2018| Leave a Comment »

Reporter: Aviva Lev-Ari, PhD, RN

ALXERION

2007 IDE for Exosome-based drug delivery system in 2018 in Phase III clinical system

In Argentina – Biobank of Exosomes 35,000 sequensed for new drugs in Partnership with MIT

Speakers

Mercedes Balcells, PhD Principal Research Scientist atMIT Institute for Medical Engineering and Science

PI working with Prof. Edelman

Elazer Edelman, MD, PhD Director of the Harvard-MIT Biomedical Engineering Center, Director of MIT’s Institute for Medical Engineering & Science at Harvard-MIT

NOT Attended

Dr. Javier Pedreño, LLM,MD,MSc, PhD Founder & CEO at Alxerion Biotech Corporation

DNA samples can be collected for RNA sequences best conditions in lab are needed
EXOKIT Cartilege – personalized exosome-based medicines – drug delivery device & system technology for PM
High throughput for screening exosomes for genetic drugs,
Conflict among species: Fungus and Bacteria – cross communication
incubate samples in invitro conditiond as in nature and the Medium has the entire ecosystem – a sample of – basal conditions technologies
intra extra viscicles
strong discovery and strong delivery
In a month – launch of Cancer new drug, lung, use isolated exosome

Venue Website Get Directions

Posted in Conference Coverage with Social Media, Drug Carrier Design, Drug Delivery Platform Technology, Medical Devices R&D Investment, Medication Remote Compliance Monitoring on April 5, 2018| Leave a Comment »

Reporter: Aviva Lev-Ari, PhD, RN

Westin Waltham Boston

70 3rd Avenue Waltham MA US 02451

@pharma_BI

@AVIVA1950

MassBio’s second annual Medical Device Event will focus on opportunities and advances in drug delivery, including the unique developmental and regulatory challenges these products face, the many scientific advances in the space and new opportunities for funding. Panelists will discuss innovation and commercialization strategies.

Advances in drug delivery technologies are improving the safety and efficacy of new and existing therapies. The success of many new therapies in development is contingent on the development of effective delivery systems. Traditional drug delivery methods won’t work for some compounds and biologics. Stability issues create challenges for storage and transport. There are opportunities for combination drug delivery products to extend the patent life of drugs on the market. From diffusion based polymer systems to complex delivery devices utilizing diagnostic sensors and sophisticated control systems for precise and timely delivery of life-saving agents, a diverse set of scientific and engineering disciplines are being brought to bear within this space. However, combination products involve components that would normally be developed under different types of regulations, design criteria, and controls. This symposium will explore many of the diverse aspects impacting drug delivery products.

This event will feature an active exhibit hall, panel discussions, a keynote speaker and networking sessions. This is an excellent opportunity for companies to reach a diverse audience that represents nearly every aspect of the life sciences industry, including academic researchers, entrepreneurs, device engineers and biopharma executives.

Clinicians will discuss the medical challenges for which drug delivery innovations have provided a unique solution. Academic researchers will discuss scientific advances which may lead to breakthrough products. Entrepreneurs will discuss strategies for funding new product ventures, and development issues specific to drug delivery products. Corporate speakers will discuss the challenges across the value chain of manufacturing and selling combination products globally. Regulatory speakers will address current thinking and approaches to drug delivery products within government agencies, both US and internationally.

SOURCE

https://www.massbio.org/events/the-convergence-of-medical-devices-and-drugs-advances-in-drug-delivery-2624?utm_campaign=med-device-18&utm_medium=email&utm_source=email-signature&utm_content=&utm_term=

Registration

12:00 pm – 12:30 pm

Opening Remarks

12:30 pm – 12:45 pm

Keynote Presentation

12:45 pm – 1:15 pm

Innovation & Development Panel

1:30 pm – 2:45 pm

Networking Break

2:45 pm – 3:15 pm

Commercialization Pathways Panel

3:15 pm – 4:30 pm

Networking Reception

4:30 pm – 5:30 pm

Bob Coughlin, President & CEO, MassBio

Intraperiotneal Chemotherapy needed to remove the few cells left after surgery _ delivery of drugs to a single compartment
Hyperthermic Intraperiotneal Chemotherapy
Tumor burden – stage 3 women ovarian cancer
Extended IP drug exposure
device for drug delivery to the bladder (cancer): Inflammatory bladder disease, overactive Bladder, bladder (cancer); bladder removal (radical cystectomy – residual tumor size 3 cm tumor)
Local Drug delivery for stone disease in ureter
Change the pharmacology and change the lesion in the bladder – lesion disappeared in a single compartment
Mutation burden in Brain Cancer and in Ovarian Cancer much smaller than in Lung cancer
local drug delivery to one location in the brain and the drug will be carried to the entire body – pathology of the brain leads to different disease related to the Human Brain. Treatment of hemorrhage
Cervical cancer under MRI deliver drug to the tumor hypoxy of the tumor, guide the drug dosage using imaging MRI is Radiation therapy not drug therapy

Basic research to clinical development: Drug delivery System

Benjamin S. Bleier, MD, FACS, FARS, Associate Professor, Director of Endoscopic Skull Base Surgery, Co-Director Center for Thyroid Eye Disease and Orbital Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School

BBB – Invasive, Non-invasive, Drug modification
Platform technology , Enabling technology to pass BBB Scalable technology: SAfe
Nasal bleed
Nasal Cavity – ENTRY point to the brain use vascularized tissue
nasal mucosa more permeable that any other tissue – diffuse drugs into the brain
Autologous tissue – Nasal Mucosa: Proteins Oligonucleotides,

Maria Palasis, President and CEO, 480 Biomedical, Inc.
Maria Berkman, MD, MBA, Director and Head of MedTech practice, Broadview Ventures
Evan Sherr

Brent Buchine, Ph.D., Co-Founder and CTO, Windgap Medical, Inc.

Moderator: Harry Glorikian, General Partner, New Ventures Funds

Paul Just, PharmD, Senior Principal, Medical Device Health Economics, ICON plc

VALUE (outcome achieved per $) is the currency for market ACCESS knock down barriers Care COST
Physician choose product that they wish to use while providing therapy as the lowest cost
Assessing Differentiating Value and Reimbursement
No guidance for combination products: New method of treating patients: Drug-Device
Value: Who benefits from the Value – Target stakeholders: 90 days vs 18-24 month, long term value

Pamela J. Weagraff, Director, MedTech Regulatory, IQVIA [Quantile merged IMS]

MedTech meet BioPharma
Clinical data requirements for medical devices on the increase but not not necessarily in many cases
Combination Products: Microfluidics, micronization – not chemistry but features of the drug delivery device
Option 1,2,3 for Combination Product Pathways: Draft Guidance –>> FINAL immediately in effect

Jessica Ballinger, Chief Operating Officer, Lyndra

Lyndra’s Ultra-long drug release – Extended Release Oral Capsule: 7 days
Dosage Form – Safety
Drug delivery – material manufacturing for long term resident inside the human body
Candidates: AD, Diabetes
Encapsulation automated – 3 partners assembly in several int’l locations in the supply chain: complications in making tablets – three years before the launch, freeze design 1st generation, 2nd generation

Steven Rosenberg, Otsuka Pharmaceutical

http://pharmaceuticalintelligence.com

Posted in Conference Coverage with Social Media, Drug Delivery Platform Technology, Drug Development Process, Drug Discovery Chemistry, Personalized and Precision Medicine & Genomic Research, Pharmaceutical Analytics, Pharmaceutical Discovery, Pharmaceutical Drug Discovery, Pharmaceutical Industry Competitive Intelligence, Pharmaceutical R&D Informatics, Pharmaceutical R&D Investment, Pharmacodynamics and Pharmacokinetics, Pharmacogenomics, Pharmacologic toxicities on February 21, 2018| Leave a Comment »

Reporter: Aviva Lev-Ari, PhD, RN

Dr. Aviva Lev-Ari, PhD, RN, Editor-in-Chief, PharmaceuticalIntelligence.com will be in attendance covering this event for the Press using Social Media via 12 Channels

LOGO of LPBI Group

Our Journal has 1,373,977 eReaders on 1/29/2018, for All Time and 7,283 Scientific Comments

Aviva’s – +6,430 BIOTECH Followers on LinkedIn

http://www.linkedin.com/in/avivalevari

Aviva is a Member of +60 LinkedIn Groups in Biotech related fields

https://www.linkedin.com/groups/my-groups

LPBI Group’s FaceBook Page

http://www.facebook.com/LeadersInPharmaceuticalBusinessIntelligence

https://pharmaceuticalintelligence.com/2016/05/12/preliminary-agenda-available-and-exclusive-discount-to-attend-understanding-crispr-mechanisms-to-applications-symposium-in-boston-september-19-2016

LPBI Group’s Twitter Account

http://twitter.com/pharma_BI

LinkedIn (LI) Group Launcher and Manager of Three LI Groups

Cardiovascular Biotech & Pharma UK & US Networking Group

918 members (1/2018)

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342 members (1/2018)

Innovation in Israel

188 members (1/2018)

LPBI Group’s Company’s Page on LinkedIn

https://www.linkedin.com/company/9325543?trk=tyah&trkInfo=clickedVertical%3Acompany%2CclickedEntityId%3A9325543%2Cidx%3A1-1-1%2CtarId%3A1439226813927%2Ctas%3ALeaders%20in%20Pharmaceutica

For PROGRAMS, go to

September 26-27

September 27-28

September 26-27

September 27-28

September 26-27

September 27-28

September 26-27

September 27-28

September 25

Leadership we provide on curation of scientific findings in the eScientific publishing for Medical Education contents.

In Section 1, the Leadership we provide on curation of scientific findings in the eScientific publishing for Medical Education contents is demonstrated by a subset of several outstanding curations with high electronic Viewer volume. Each article included presents unique content contribution to Medical Clinical Education.

· These articles are extracted from the list of all Journal articles with >1,000 eReaders, 4/28/2012 to 1/29/2018.

Article Title, # of electronic Viewers, Author(s) Name

Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?

16,114

Larry H. Bernstein, MD, FCAP

Do Novel Anticoagulants Affect the PT/INR? The Cases of XARELTO (rivaroxaban) and PRADAXA (dabigatran)		11,606	Vivek Lal, MBBS, MD, FCIR, Justin D. Pearlman, MD, PhD, FACC and Aviva Lev-Ari, PhD, RN
Clinical Indications for Use of Inhaled Nitric Oxide (iNO) in the Adult Patient Market: Clinical Outcomes after Use, Therapy Demand and Cost of Care		5,865	Aviva Lev-Ari, PhD, RN
Peroxisome proliferator-activated receptor (PPAR-gamma) Receptors Activation: PPARγ transrepression for Angiogenesis in Cardiovascular Disease and PPARγ transactivation for Treatment of Diabetes	1,919			Aviva Lev-Ari, PhD, RN

Bystolic’s generic Nebivolol – Positive Effect on circulating Endothelial Progenitor Cells Endogenous Augmentation

1,059

Aviva Lev-Ari, PhD, RN

Triple Antihypertensive Combination Therapy Significantly Lowers Blood Pressure in Hard-to-Treat Patients with Hypertension and Diabetes

1,339

Aviva Lev-Ari, PhD, RN

Clinical Trials Results for Endothelin System: Pathophysiological role in Chronic Heart Failure, Acute Coronary Syndromes and MI – Marker of Disease Severity or Genetic Determination?	1,472		Aviva Lev-Ari, PhD, RN
Treatment of Refractory Hypertension via Percutaneous Renal Denervation	1,085		Aviva Lev-Ari, PhD, RN

Select

Aviva Lev-Ari, PhD, RN 2012pharmaceutical

3,064 Articles

· All (5,288)

avivalev-ari@alum.berkeley.edu

Administrator

3064

2.1 Volume of Articles in the Journal and in the 16 Volume-BioMed e-Series

1. Volume of Articles in the Journal since Journal inception on 4/28/2012:

· Total articles by ALL authors in Journal Archive on 1/29/2018 = 5,288

· ALL articles/posts Authored, Curated, Reported by Aviva Lev-Ari, PhD, RN = 3,064

2. Volume of Articles in the 16 Volume-BioMed e-Series

· Editorial & Publication of Articles in e-Books by Leaders in Pharmaceutical Business Intelligence: Contributions of Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2014/10/16/editorial-publication-of-articles-in-e-books-by-leaders-in-pharmaceutical-business-intelligence-contributions-of-aviva-lev-ari-phd-rn/

· LPBI Group’s Founder: Biography and Bibliographies – Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/founder/

2.2 Digital Presence measured by eViews: Clicks on article by Author Name

Top Authors for all days ending 2018-01-29 (Summarized)

All Time

Author Name		electronic Views
Aviva Lev-Ari, PhD, RN [2012pharmaceutical]		352,153

LPBI Group

1,201

2.3 Digital KOL Parameters

Key Opinion Leader (KOL) – Aviva Lev-Ari, PhD, RN, as Evidenced by

https://pharmaceuticalintelligence.com/2016/07/21/key-opinion-leader-kol-aviva-lev-ari-phd-rn-as-evidenced-by/

L.H. Bernstein, MD, FCAP

Editorial & Publication of Articles in e-Books by Leaders in Pharmaceutical Business Intelligence: Contributions of Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2014/10/16/editorial-publication-of-articles-in-e-books-by-leaders-in-pharmaceutical-business-intelligence-contributions-of-larry-h-bernstein-md-fcap/

As BioMed e-Series Editor–in-Chief, I was responsible for the following functions of product design and product launch

· 16 Title creations for e-Books

· Designed 16 Cover Pages for a 16-Volume e-Books e-Series in BioMed

· Designed Series A eTOCs and approved of all 16 electronic Table of Contents (eTOCs), working in tandem with all the Editors of each volume and all the Author contributors of article contents in the Journal.

· Commissioned Articles by Authors/Curators per Author’s expertise on a daily basis

Below, see Volume Titles and Cover Pages:

13 LIVE results for Kindle Store: “Aviva Lev-Ari”

Oct 16, 2017 | Kindle eBook

by Larry H. Bernstein and Aviva Lev-Ari

Subscribers read for free.

$49.00^$ 49 ⁰⁰ to buy Kindle Edition

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

May 13, 2017 | Kindle eBook

by Larry H. Bernstein and Demet Sag

Subscribers read for free.

$100.00^$ 100 ⁰⁰ to buy Kindle Edition

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

Sep 4, 2017 | Kindle eBook

by Larry H. Bernstein and Aviva Lev-Ari

Subscribers read for free.

$115.00^$ 115 ⁰⁰ to buy Kindle Edition

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

Jun 20, 2013 | Kindle eBook

by Margaret Baker PhD and Tilda Barliya PhD

Subscribers read for free.

Get it TODAY, Jan 29

5 out of 5 stars 6

Sold by: Amazon Digital Services LLC

Dec 9, 2017 | Kindle eBook

by Larry H. Bernstein and Aviva Lev-Ari

Subscribers read for free.

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

Nov 28, 2015 | Kindle eBook

by Justin D. Pearlman MD ME PhD MA FACC and Stephen J. Williams PhD

Subscribers read for free.

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

Nov 29, 2015 | Kindle eBook

by Larry H. Bernstein MD FCAP and Aviva Lev-Ari PhD RN

Subscribers read for free.

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

Dec 30, 2017 | Kindle eBook

by Larry H. Bernstein and Irina Robu

Subscribers read for free.

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

Jul 21, 2015 | Kindle eBook

by Larry H. Bernstein MD FCAP and Prabodah Kandala PhD

Subscribers read for free.

Get it TODAY, Jan 29

5 out of 5 stars 1

Sold by: Amazon Digital Services LLC

Aug 10, 2015 | Kindle eBook

by Larry H Bernstein MD FCAP and Prabodh Kumar Kandala PhD

Subscribers read for free.

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

Nov 22, 2015 | Kindle eBook

by Sudipta Saha PhD and Ritu Saxena PhD

Subscribers read for free.

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Sold by: Amazon Digital Services LLC

Dec 26, 2015 | Kindle eBook

by Larry H. Bernstein MD FACP and Aviva Lev-Ari PhD RN

Subscribers read for free.

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

Dec 26, 2015 | Kindle eBook

by Justin D. Pearlman MD ME PhD MA FACC and Ritu Saxena PhD

Subscribers read for free.

Get it TODAY, Jan 29

Sold by: Amazon Digital Services LLC

As BioMed e-Series Editor–in-Chief, Aviva Lev-Ari, PhD, RN was responsible for

· All the documentation (Instruction manuals) on Style setting, and for

· Training all team members

· Journal Articles Format

· Journal Comment Exchange Format

· e-Books Production Process:

1. Volume creation from Journal’s Article Archive,

2. Format Translation from HTML to .mobi for Kindle devices,

3. Proof reading process,

4. Title release,

5. Book electronic Upload to Amazon.com Cloud.

6. Connection of all articles and e-Books to Social Media, Ping back generation by mentioning other related articles published in the Journal

Lastly, 6, below

Title	Date of Publication	Number of Pages
Perspectives on Nitric Oxide in Disease Mechanisms	6/21/2013	895
Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation	11/30/2015	11039 KB
Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics	11/29/2015	12333 KB
Regenerative and Translational Medicine: The Therapeutics Promise for Cardiovascular Diseases	12/26/2015	11668 KB
Genomics Orientations for Personalized Medicine	11/23/2015	11724 KB
Cancer Biology & Genomics for Disease Diagnosis	8/11/2015	13744 KB
Cancer Therapies: Metabolic, Genomics, Interventional, Immunotherapy and Nanotechnology in Therapy Delivery	5/18/2017	5408 pages
Metabolic Genomics and Pharmaceutics	7/21/2015	13927 KB
The Immune System, Stress Signaling, Infectious Diseases and Therapeutic Implications	9/4/2017	3747 pages
The VOICES of Patients, Hospitals CEOs, Health Care Providers, Caregivers and Families: Personal Experience with Critical Care and Invasive Medical Procedures	10/16/2017	826 pages
Medical Scientific Discoveries for the 21st Century & Interviews with Scientific Leaders	12/9/2017	2862 pages
Milestones in Physiology: Discoveries in Medicine, Genomics and Therapeutics	12/27/2015	11125 KB
Medical 3D BioPrinting – The Revolution in Medicine, Technologies for Patient-centered Medicine: From R&D in Biologics to New Medical Devices	12/30/2017	1005 pages
Pharmacological Agents in Treatment of Cardiovascular Disease	Work-in-Progress, Expected Publishing date in 2018	???
Interventional Cardiology and Cardiac Surgery for Disease Diagnosis and Guidance of Treatment	Work-in-Progress, Expected Publishing date in 2018	???

https://www.bloomberg.com/news/articles/2017-11-14/fda-approves-a-digital-pill-that-can-track-when-you-swallowed-it

Posted in Medication Remote Compliance Monitoring on November 14, 2017| Leave a Comment »

Reporter: Aviva Lev-Ari, PhD, RN

The so-called digital pill is a version of Otsuka Pharmaceutical Co.’s Abilify, which treats depression, bipolar disorder and schizophrenia. The sensor, developed by Proteus Digital Health, is activated by stomach fluids, sending a signal to a patch worn on the patient’s torso and transmitting the information to a smartphone app.

Sensor in depression pill transmits data to a smartphone app

Lets doctors track patient’s use, prevent missing medicines

SOURCE