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Physiologist, Professor Lichtstein, Chair in Heart Studies at The Hebrew University elected Dean of the Faculty of Medicine at The Hebrew University of Jerusalem

Posted in Bio Instrumentation in Experimental Life Sciences Research, Biological Networks, Gene Regulation and Evolution, Biomarkers & Medical Diagnostics, Biomedical Measurement Science, BioSimilars, Cardiovascular Pharmacogenomics, Cardiovascular Research, Cell Biology, Signaling & Cell Circuits, Cerebrovascular and Neurodegenerative Diseases, Chemical Biology and its relations to Metabolic Disease, Chemical Genetics, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Drug Delivery Platform Technology, Electrophysiology, Frontiers in Cardiology and Cardiovascular Disorders, Human Sensation and Cellular Transduction: Physiology and Therapeutics, Ionic Transporters Na+, Na-K transport, Origins of Cardiovascular Disease, Pharmacotherapy and Cell Activity, Pharmacotherapy of Cardiovascular Disease, Scientist: Career considerations, Technology Transfer: Biotech and Pharmaceutical, Translational Research, Translational Science, Water Transporters, tagged Hebrew University of Jerusalem, pharmacology, Roche Institute of Molecular Biology on December 18, 2013| Leave a Comment »

Physiologist, Professor Lichtstein, Chair in Heart Studies at The Hebrew University elected Dean of the Faculty of Medicine at The Hebrew University of Jerusalem

Reporter: Aviva Lev-Ari, PhD, RN

Professor David Lichtstein Elected Dean of Hebrew University’s Faculty of Medicine

December 2, 2013

Jerusalem — Professor David Lichtstein has been elected dean of the Faculty of Medicine at The Hebrew University of Jerusalem. Professor Lichtstein is the Walter & Greta Stiel Chair in Heart Studies at The Hebrew University. He replaces Professor Eran Leitersdorf, who recently completed his four-year term as dean.

According to Professor Lichtstein, “The Hebrew University’s Faculty of Medicine is devoted to creating innovative teaching, research and patient care programs that will meet the demands of 21st century health care. As global health care moves toward prevention, wellness and cost effectiveness, we are adapting how we train the next generation of physicians, nurses, pharmacists and biomedical researchers. Through fruitful collaborations between preclinical and clinical faculty, we are also translating basic biomedical insights into clinical treatments. Thus, the Faculty of Medicine is well-positioned to maintain its leading role in the scientific community of Israel and the world.”

Professor Lichtstein was born in Lodz, Poland, and immigrated to Israel with his family in 1957. As a student at The Hebrew University, he completed a Bachelor’s degree in Physiology and Zoology in 1970, followed by a Master’s degree in Physiology in 1972 and a Ph.D. in Physiology in 1977. He joined the Department of Physiology of The Hebrew University-Hadassah Medical School in 1980 as a lecturer, and received full professorship in 1994. Prof. Lichtstein has held many roles at The Hebrew University and its Faculty of Medicine, including Chairman of the Neurobiology Teaching Division, Chairman of the Department of Physiology, Chairman of the Institute for Medical Sciences and, until recently, Chairman of the Faculty of Medicine. From 2007 to 2011, Professor Lichtstein was the Jacob Gitlin Chair in Physiology at The Hebrew University. In 2011 he was named the Walter & Greta Stiel Chair in Heart Studies at The Hebrew University. He also served as the President of the Israel Society for Physiology and Pharmacology from 1996 to 1999.

From 1977-1979 Professor Lichtstein was a Postdoctoral Fellow at the Roche Institute of Molecular Biology in New Jersey. He was a visiting scientist at the National Institute of Child Health and Human Development (1985-1986) and the Eye Institute (1997-1998) at the National Institutes of Health in Maryland, and a visiting professor at the Toledo School of Medicine in Ohio (2007).

Professor. Lichtstein’s main research focus is the regulation of ion transport across the plasma membrane of eukaryotic cells. His work led to the discovery that specific steroids that were known to be present in plants and amphibians are actually normal constituents of the human body and have crucial roles, such as the regulation of cell viability, heart contractility, blood pressure and brain function. His research has implications for the fundamental understanding of body functions, as well as for several pathological states such as heart failure, hypertension and neurological and psychiatric diseases.

SOURCE

http://www.afhu.org/professor-david-lichtstein-elected-dean-hebrew-universitys-faculty-medicine

Field of Study

Regulation of ion transport across the plasma membrane:

The primary focus of the research in my laboratory is the regulation of ion transport across the plasma membrane of eukaryotic cells. In particular, we study the main transport system for sodium and potassium, the sodium-potassium-ATPase, and its regulation by cardiac steroids.

Specific areas of interest:

Identification of endogenous cardiac steroids in mammalian tissue; The biological consequences of the interaction of cardiac steroids with the sodium-potassium-ATPase; Biosynthesis of the cardiac steroids in the adrenal gland; Effects of endogenous sodium-potassium-ATPase inhibitors on cell differentiation; Determination of the levels of endogenous sodium-potassium-ATPase inhibitors in pathological states, including hypertension, preeclampsia; malignancies (cancer) and manic depressive illnesses; Involvement of the sodium-potassium–ATPase/cardiac steroids system in depressive disorders; Involvement of the sodium-potassium-ATPase/cardiac steroids system in cardiac function; Involvement of intestinal signals in the regulation of phosphate homeostasis; Volume regulation and its involvement in the mitogenic response.

Cardiac Steroids and the Na+, K+-ATPase and Cardiac Steroids

Cardiac steroids, such as ouabain, digoxin and bufalin are hormones synthesized by and released from the adrenal gland and the hypothalamus. These compounds, the structure of which resembles that of plant and amphibian and butterfly steroids, interact only with the plasma membrane Na+, K+-ATPase (Figure 1). This interaction elicits numerous specific biological responses affecting the function of cells and organs.

Topics Currently under investigation include

Cardiac Steroids

• Ouabain
• Bufalin
• Dogoxin

Involvement of the sodium-potassium–ATPase/cardiac steroids system in depressive disorders

Depressive disorders, including major depression, dysthymia and bipolar disorder, are a serious and devastating group of diseases that have a major impact on the patients’ quality of life, and pose a significant concern for public health. The etiology of depressive disorders remains unclear. The Monoaminergic Hypothesis, suggesting that alterations in monoamine metabolism in the brain are responsible for the etiology of depressive disorders, is now recognized as insufficient to explain by itself the complex etiology of these diseases. Data from our and other laboratories has provided initial evidence that endogenous cardiac steroids and their only established receptor, the Na+, K+-ATPase, are involved in the mechanism underlining depressive disorders, and BD in particular. Our study (Biol. Psychiatry. 60:491-499, 2006) has proven that Na+, K+-ATPase and DLC are involved in depressive disorders particularly in manic-depression. We have also shown that specific genetic alterations in the Na+, K+-ATPase α isoforms are associated with bipolar disorders (Biol. Psychiatry, 65:985-991, 2009). Our recent study in this project (Eur. Neuropsychopharmacol. 22:72-729, 2012) showed that drugs affecting the Na+, K+-ATPase/cardiac steroids system are beneficial for the treatment of depression. Hence our work is in accordance to the proposition that mal functioning of the Na+, K+-ATPase/cardiac steroids system may be involved in manifestation of depressive disorders and identify new compounds as potential drug for the treatment of these maladies.

Involvement of the sodium-potassium-ATPase/cardiac steroids system in cardiac function

The classical and best documented effect of cardiac steroids, as their name implies, is to increase the force of contraction of heart muscle. Indeed, cardiac steroids were widely used in Western and Eastern clinical practices for the treatment of heart failure and atrial fibrillation. Despite extensive research, the mechanism underlying cardiac steroids actions have not been fully elucidated. The dogmatic explanation for cardiac steroids-induced increase in heart contractility is that the inhibition of Na+, K+-ATPase by the steroids causes an increase in intracellular Na+ which, in turn, attenuates the Na+/Ca++ exchange, resulting in an increased intracellular Ca++ concentration, and hence greater contractility. However, recent observations led to the hypothesis that the ability of cardiac steroids to modulate a number of intracellular signaling processes may be responsible for both short- and long-term changes in CS action on cardiac function. We are addressing this hypothesis using the zebrafish model and our ability to quantify heart function in-vivo. Heart contractility measurements were performed using a series of software tools for the analysis of high-speed video microscopic images, allowing the determination of ventricular heart diameter and perimeter during both diastole and systole. The ejection fraction (EF) and fractional area changes (FAC) were calculated from these measurements, providing two independent parameters of heart contractility (see attached movie bellow). We are currently testing the effect of cardiac steroids in the presence and absence of intracellular signaling pathways (MAP, AKT, IP3R) inhibitors. Reduction in the steroids ability to increase the force of contraction will serve as the first evidence, in-vivo, for the participation of the signaling processes in the molecular mechanisms responsible for the action of cardiac steroids on heart muscle.

Laboratory Techniques

We employ a broad range of preparations and techniques. These include isolated organs (arterial rings, smooth and cardiac muscle strips) and isolated nerve endings, as well as primary and established tissue-cultured cells. Our studies involve the application of biochemical and immunological techniques (transport and enzymatic activity measurements, RIA, ELISA), molecular biological techniques (e.g., Western and Northern blotting, and PCR), protein purification (HPLC), cellular techniques muscle contractility, cell proliferation and differentiation’ in-vivo measurements of heart contractility and blood flow in Zebrafish and behavior measurements in rodents.

Biography

Education

1970	B.Sc. in Physiology and Zoology, The Hebrew University, Jerusalem, Israel
1970-1972	M.Sc. in Physiology, Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel.
1973-1977	Ph.D., Department of Physiology, Hebrew University Hadassah Medical School, Jerusalem, Israel. (Thesis: “Increased Production of Gamma Aminobutyryl choline in Cerebral Cortex Caused by Afferent Electrical Stimulation” (Thesis Advisors: Prof. J. Dobkin and Prof. J. Magnes).
1977-1979	Postdoctoral Fellow, Department of Physiological Chemistry and Pharmacology, Roche Institute of Molecular Biology, Nutley, New Jersey, U.S.A.

Positions held

1970-1972	Teaching and Research Assistant, Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
1972-1974	Assistant Instructor, Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
1975-1977	Instructor, Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
1977-1979	Postdoctoral Fellow, Department of Physiological Chemistry and Pharmacology, Roche Institute of Molecular Biology, Nutley, New Jersey, U.S.A.
1979-1983	Lecturer, (REVSON fellowship) Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
1981 (summer)	Visiting Scientist, Department of Physiological Chemistry and Pharmacology, Roche Institute of Molecular Biology, Nutley, New Jersey, USA
1983-1987	Senior Lecturer, Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
1985-1986	Visiting Scientist, Laboratory of Theoretical and Physical Biology, NICHD, National Institutes of Health, Bethesda, Maryland, USA
1988-1994	Associate Professor, Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
1994-present	Professor of Physiology, Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
1997-1998	Visiting Scientist, Laboratory of Mechanisms of Ocular Diseases, NEI, National Institutes of Health, Bethesda, Maryland, USA
2007 (summer)	Visiting Professor, Department of Physiology, Pharmacology, Metabolism and cardiovascular Sciences, Medical Center University of Toledo, Toledo, Ohio, USA
2007-2011	Jacob Gitlin Chair in Physiology, The Hebrew University, Jerusalem, Israel
​2011-present	​Walter & Greta Stiel Chair in Heart Studies, The Hebrew University, Jerusalem

Professional Membership

1979-present	International Society of Neurochemistry
1979-present	Israel Society for Physiological and Pharmacological
1980-present	Society of Neurosciences (Europe)
1986-present	The American Society of Hypertension
1992-present	Israeli Society for Neurosciences
1999-present	The American Physiological Society

Editorial Tasks

Serving as a Reviewer for the scientific journals:
•	American Journal of Hypertension		•	Journal of Neural Transmission
•	American Journal of Physiology		•	Journal of Neurochemistry
•	Apoptosis		•	Journal of Pharmacology and Experimental Therapeutics
•	Biochemical and Biophysical Research Communications		•	Life Sciences
•	Basic Journal of Physiology and Pharmacology		•	NANO
•	Brain Research		•	Neurochemistry International
•	Bioconjugate Chemistry		•	Neuroscience
•	Cell Calcium		•	Neurotoxicity Research
•	Clinical Science		•	Pathophysiology
•	Endocrinology		•	Physiology and Behavior
•	European Neuropsychopharmacology		•	PNAS
•	General and Comparative Endocrinology		•	Psychiatry Research
•	Hypertension		•	Translational Research
•	Journal of Cell Sciences

University and Other Activities

1982-1985	Chairman of the Neurobiology Teaching Division, The Hebrew University, Jerusalem
1988-1994	Elected representative of the Senior Lecturers and Associate Professors for the University Senate
1989-1997	Member of the admission committee of the Medical School, The Hebrew University, Jerusalem
1990-1996	Member of the Committee for cellular biology of the graduate studies, The Hebrew University, Jerusalem
1992-1996	Member of the Teaching Committee, Faculty of Medicine, The Hebrew University, Jerusalem
1992-1996	Chairman, Department of Physiology, The Hebrew University, Hadassah Medical School, Jerusalem
1994-1997	Member of the Committee for graduate studies, The Hebrew University, Jerusalem
1992-2002	Member of the Management Committee of The Institute for Medical Sciences, Faculty of Medicine, The Hebrew University, Jerusalem
1996-1999	President of the Israel Society for Physiology and Pharmacology
1998- 2002	Chairman, Institute of Medical Sciences, The Hebrew University, Hadassah Medical School, Jerusalem
1999-2002	Member of the Planning and Development Committee of the Faculty of Medicine, The Hebrew University, Jerusalem
2007–Present	Elected representative of the Professors for the executive University Senate
2008-2012	Member of the Planning and Development Committee of the Faculty of Medicine, The Hebrew University, Jerusalem
2008-2012	Chairman, Institute for Medical Research Israel-Canada, The Hebrew University, Hadassah Medical School, Jerusalem
2009 – Present	Elected member of the Senate to the Executive Committee of the Hebrew University

 https://medicine.ekmd.huji.ac.il/En/Publications/ResearchersPages/pages/davidli.aspx

PUBLICATIONS 2006 – 2012

Use link below for earlier publications

https://medicine.ekmd.huji.ac.il/En/Publications/publications/Pages/default.aspx?aut=Lichtstein,%20D

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C., Lichtstein, D. Endogenous ouabain regulates cell viability American journal of physiology. Cell physiology, 302(2), C442-52, 2012 JCR Impact FactorAbstract Goldstein, I., Lax, E., Gispan-Herman, I., Ovadia, H., Rosen, H., Yadid, G., Lichtstein, D. Neutralization of endogenous digitalis-like compounds alters catecholamines metabolism in the brain and elicits anti-depressive behavior European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 22(1), 72-9, 2012 JCR Impact FactorAbstract Feldmann, T., Shahar, M., Baba, A., Matsuda, T., Lichtstein, D., Rosen, H. The Na(+)/Ca(2+)-exchanger: an essential component in the mechanism governing cardiac steroid-induced slow Ca(2+) oscillations Cell calcium, 50(5), 424-32, 2011 JCR Impact FactorAbstract Nesher, M., Shpolansky, U., Viola, N., Dvela, M., Buzaglo, N., Cohen Ben-Ami, H., Rosen, H., Lichtstein, D. Ouabain attenuates cardiotoxicity induced by other cardiac steroids British journal of pharmacology, 160(2), 346-54, 2010 JCR Impact FactorAbstract Guttmann-Rubinstein, L., Lichtstein, D., Ilani, A., Gal-Moscovici, A., Scherzer, P., Rubinger, D. Evidence of a parathyroid hormone-independent chronic effect of estrogen on renal phosphate handling and sodium-dependent phosphate cotransporter type IIa expression Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 42(4), 230-6, 2010 JCR Impact FactorAbstract Jaiswal, M. K., Dvela, M., Lichtstein, D., Mallick, B. N. Endogenous ouabain-like compounds in locus coeruleus modulate rapid eye movement sleep in rats Journal of sleep research, 19(1 Pt 2), 183-91, 2010 JCR Impact FactorAbstract Nesher, M., Dvela, M., Igbokwe, V. U., Rosen, H., Lichtstein, D. Physiological roles of endogenous ouabain in normal rats American journal of physiology. Heart and circulatory physiology, 297(6), H2026-34, 2009 JCR Impact FactorAbstract Goldstein, I., Lerer, E., Laiba, E., Mallet, J., Mujaheed, M., Laurent, C., Rosen, H., Ebstein, R. P., Lichtstein, D. Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders Biological psychiatry, 65(11), 985-91, 2009 JCR Impact FactorAbstract Nesher, M., Vachutinsky, Y., Fridkin, G., Schwarz, Y., Sasson, K., Fridkin, M., Shechter, Y., Lichtstein, D. Reversible pegylation prolongs the hypotensive effect of atrial natriuretic peptide Bioconjugate chemistry, 19(1), 342-8, 2008 JCR Impact FactorAbstract Dvela, M., Rosen, H., Feldmann, T., Nesher, M., Lichtstein, D. Diverse biological responses to different cardiotonic steroids Pathophysiology : the official journal of the International Society for Pathophysiology / ISP, 14(3-4), 159-66, 2007 JCR Impact FactorAbstract Feldmann, T., Glukmann, V., Medvenev, E., Shpolansky, U., Galili, D., Lichtstein, D., Rosen, H. Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis American journal of physiology. Cell physiology, 293(3), C885-96, 2007 JCR Impact FactorAbstract Chirinos, J. A., Corrales-Medina, V. F., Garcia, S., Lichtstein, D. M., Bisno, A. L., Chakko, S. Endocarditis associated with antineutrophil cytoplasmic antibodies: a case report and review of the literature Clinical rheumatology, 26(4), 590-5, 2007 JCR Impact FactorAbstract Nesher, M., Shpolansky, U., Rosen, H., Lichtstein, D. The digitalis-like steroid hormones: new mechanisms of action and biological significance Life sciences, 80(23), 2093-107, 2007 JCR Impact FactorAbstract Lichtstein, D. M., Arteaga, R. B. Rhabdomyolysis associated with hyperthyroidism The American journal of the medical sciences, 332(2), 103-5, 2006 JCR Impact FactorAbstract Morla, D., Alazemi, S., Lichtstein, D. Stauffer’s syndrome variant with cholestatic jaundice: a case report Journal of general internal medicine, 21(7), C11-3, 2006 JCR Impact FactorAbstract Chirinos, J. A., Corrales, V. F., Lichtstein, D. M. ANCA-associated large vessel compromise Clinical rheumatology, 25(1), 111-2, 2006 JCR Impact FactorAbstract Deutsch, J., Jang, H. G., Mansur, N., Ilovich, O., Shpolansky, U., Galili, D., Feldman, T., Rosen, H., Lichtstein, D. 4-(3’alpha15’beta-dihydroxy-5’beta-estran-17’beta-yl)furan-2-methyl alcohol: an anti-digoxin agent with a novel mechanism of action Journal of medicinal chemistry, 49(2), 600-6, 2006 JCR Impact FactorAbstract Goldstein, I., Levy, T., Galili, D., Ovadia, H., Yirmiya, R., Rosen, H., Lichtstein, D. Involvement of Na(+) Biological psychiatry, 60(5), 491-9, 2006 JCR Impact FactorAbstract Chirinos, J. A., Garcia, J., Alcaide, M. L., Toledo, G., Baracco, G. J., Lichtstein, D. M. Septic thrombophlebitis: diagnosis and management American journal of cardiovascular drugs : drugs, devices, and other interventions, 6(1), 9-14, 2006 JCR Impact FactorAbstract Rosen, H., Glukmann, V., Feldmann, T., Fridman, E., Lichtstein, D. Short-term effects of cardiac steroids on intracellular membrane traffic in neuronal NT2 cells Cellular and molecular biology (Noisy-le-Grand, France), 52(8), 78-86, 2006 JCR Impact FactorAbstract

SOURCE

https://medicine.ekmd.huji.ac.il/En/Publications/publications/Pages/default.aspx?aut=Lichtstein,%20D

 

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