Archive for the ‘R&D Expenditure’ Category

2020 World Medical Innovation Forum – COVID-19, AI  – Life Science and Digital Health Investments, MGH & BWH, Virtual Event: Monday, May 11, 8:15 a.m. – 5:15 p.m. ET

Reporter: Aviva Lev-Ari, PhD, RN




Life science and digital health investments have continued at a strong pace during the COVID-19 crisis. Senior investment leaders discuss what to expect. Will:

  • social distancing affect deal making?
  • key asset categories remain strong – venture, private equity, public offerings, acquisitions?
  • valuations hold up in some categories while others fall?

Moderator: Roger Kitterman, VP, Venture and Managing Partner, Partners Innovation Fund, Mass General Brigham

Jan Garfinkle
, Founder & Manager Partner, Arboretum Ventures, Chair NVCA

Phillip Gross, Managing Director, Adage Capital Management

Christopher Viehbacher, Managing Partner, Gurnet Point Capital


VIEW VIDEOS from the event


From: “Coburn, Christopher Mark” <CMCOBURN@PARTNERS.ORG>

Date: Tuesday, May 12, 2020 at 6:48 AM

To: “Coburn, Christopher Mark” <CMCOBURN@PARTNERS.ORG>

Subject: REGISTRANT RECAP | World Medical Innovation Forum  


Dear World Forum Attendee, 

On behalf of Mass General Brigham CEO Anne Klibanski MD and Forum co-Chairs Gregg Meyer MD and Ravi Thadhani MD, many thanks for being among the nearly 11,000 registrants representing 93 countries, 46 states and 3200 organizations yesterday. A community was established around many pressing topics that  will continue long into the future. We hope you have a chance to examine the attached survey results. There are several revealing items that should be the basis for ongoing discussion. We expect to be in touch regularly during the year. Among the plans is a “First Look” video series highlighting top Mass General Brigham Harvard faculty as well as emerging Harvard investigators.  As promised, we  wanted to also share visual Forum session summaries.  You will be able to access the recordings on the Forum’s YouTube page . The first set will go up this morning

We hope you will join us for the 2021 Forum!  

Thanks again, Chris

e-Proceedings 2020 World Medical Innovation Forum – COVID-19, AI and the Future of Medicine, Featuring Harvard and Industry Leader Insights – MGH & BWH, Virtual Event: Monday, May 11, 8:15 a.m. – 5:15 p.m. ET


Tweets & Retweets 2020 World Medical Innovation Forum – COVID-19, AI and the Future of Medicine, Featuring Harvard and Industry Leader Insights – MGH & BWH, Virtual Event: Monday, May 11, 8:15 a.m. – 5:15 p.m. ET


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Research and Development (R&D) Expenditure by Country represent time, capital, and effort being put into researching and designing the products of the future – Data from the UNESCO Institute for Statistics adjusted for purchasing-power parity (PPP).


Reporter: Aviva Lev-Ari, PhD, RN



Measuring R&D spend

Today’s infographic comes to us from HowMuch.net, and it compares R&D numbers for nearly every country in the world. It uses data from the UNESCO Institute for Statistics adjusted for purchasing-power parity (PPP).

As a percentage of GDP

Measuring R&D in absolute terms shows where most of the world’s research happens, but it fails to capture the countries that are spending more in relative terms.

Which countries allocate the highest percentage of their economy to research and development?

As a percentage of GDP

Measuring R&D in absolute terms shows where most of the world’s research happens, but it fails to capture the countries that are spending more in relative terms.

Which countries allocate the highest percentage of their economy to research and development?

As you can see, countries like South Korea and Japan allocate the highest portion of their economies to R&D, which is part of the reason they rank so highly on the list in absolute terms as well.

As you can see, countries like South Korea and Japan allocate the highest portion of their economies to R&D, which is part of the reason they rank so highly on the list in absolute terms as well.

As you can see, R&D expenditures are heavily concentrated at the top of the food chain:

Put together the numbers for the U.S. ($476.5 billion) and China ($370.6 billion), and it amounts to 47.0% of total global R&D expenditures. Add in Japan and Germany, and the total goes to 62.5%.

At same time, the countries left off the above list don’t even combine for 15% of the world’s total R&D expenditures.

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Nature-inspired precisely assembled nanotubes

Reporter: Aviva Lev-Ari, PhD, RN




Berkeley Lab scientists discovered a polymer composed of two chemically distinct blocks (shown in orange and blue) that assembles itself into complex nanotubes.


When placed in water, this new family of nature-inspired polymers spontaneously assemble into hollow crystalline nanotubes up to 100 nanometers long with the same diameter.


“Creating uniform structures in high yield is a goal in nanotechnology,” says Ron Zuckermann, who directs the Biological Nanostructures Facility in Berkeley Lab’s Molecular Foundry, where much of this research was conducted. “For example, if you can control the diameter of nanotubes, and the chemical groups exposed in their interior, then you can control what goes through — which could lead to new filtration and desalination technologies, to name a few examples.”


Creating a large quantity of nanostructures with the same trait, such as millions of nanotubes with identical diameters, has been difficult. For the past several years, the Berkeley Lab scientists studied a polymer that is a member of the peptoid family. Peptoids are rugged synthetic polymers that mimic peptides, which nature uses to form proteins.


The researchers studied a particular type of peptoid, called a diblock copolypeptoid, because it binds with lithium ions and could be used as a battery electrolyte. In their research, they serendipitously found these compounds form nanotubes in water. They don’t know how exactly, but the important thing with this new research is that it sheds light on their structure, and hints at a new design principle that could be used to precisely build nanotubes and other complex nanostructures.


Sourced through Scoop.it from: www.kurzweilai.net

See on Scoop.itCardiovascular and vascular imaging

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Moving Electrical Charges Around Us and Electrical Standards for Human Life

Author: Danut Dragoi, PhD

Since Maxwell time, 1860’s, with its famous equations that apply to any electromagnetic effect of moving electric charges or electrons in free space or conducting materials, the field of electromagnetic effects on human being is taken into consideration by a wide range of organizations that can regulate this electromagnetic aspect in deep detail for the benefit of human kind on our planet. Even if the effect of electromagnetic field, that is a non-ionizing radiation, is not well understood today, the regulators work hard on catching every negative aspect of it that may affect us. It is the public perception that electromagnetic waves are dangerous to human being. It is sufficient to remember the early days of the wireless telephone in 90’s, when public committees took action to stop installing the transmitter towers on elevated hills or just metallic towers in the middle of many communities. Today the radio coverage is everywhere! It is dangerous? Nobody knows! Since the effect on public cannot be systematically known because of HIPAA concerns (patient’s right to privacy on medical records) on one side, or real data missing in the other side that is not representative due to low sensitivity of scientific instruments available! It is our sensors body or our feeling that can work post-effects on electromagnetic waves with small degree of accuracy. A serious analysis require special places free of electromagnetic noise to determine individual equipment electromagnetic emission. At this point I think the noise on measurements is a complicated background that require special attention. The general perception of scientists is that the actual level of electromagnetic energy impeding on us every second is not high enough, so the effect on us must be minimal. Without proof this cannot be taken as granted. In recent years appeared an electromagnetic devices such as TMS (Transcranial Magnetic Stimulation) of human brain to correct or relief some neuronal problems that affect so many. The TMS is a FDA approved instrument that can stimulate a large area of the brain with results that specialists in the field are still working on. At this point in time thinking about “Planning Ahead for IEC 60601-1-2 4th Edition for Medical EMC”  is welcome by everybody and useful for the entire society. It looks to many of us the industry is far ahead of the regulations that the main issue is hard to catch-up. Another important issue on the effects of physical fields effects on human being is that the science/knowledge of these interactions with human body is not matured enough to trace a reasonable conclusion for the benefit of human being. For about 65 years, since the invention of permanent ceramic magnets in 50’s, the effect of non-variable magnetic fields on humans remains unknown, despite the fact that there are attempts and websites to explain the effect of modern magnetotherapy  on human. Today many vendors are offering a large pallet of such devices. As we know, the scientific method has to be applied to all of these unknowns that still persists today. As we know moving electrical charges around us produce electromagnetic fields and vice versa a variable magnetic field can produce a variable electric field that can move electric charges, if they can be moved. As a society we have to impose some restrictions until this practice become dangerous. In this way the IEC 60601-1-2:2014 applies to the basic safety and essential performance of Medical Equipment (ME) that play an important role for public safety. It is our public duty to cooperate with scientists in deciphering one of the modern day challenges, what is the true effect of physical fields on human being.

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Holography inspired 3D free space display allows doctors to see a patient’s heart in mid-air during real time medical procedures

Reporter: Danut Dragot, PhD


An Israeli firm, http://www.realviewimaging.com/, has developed 3D holographic imaging technology that allows doctors to see a patient’s anatomy “floating” in mid-air during real time medical procedures. The company says successful trials of its system demonstrate that science fiction has become science fact. To properly illustrate its three dimensional, holographic technology, Realview Imaging has produced a video demonstrating what it says an observer would see in an operating theatre. The company says the technology gives surgeons an unprecedented look at their patient’s anatomy as they’re operating. Doctor Elchanan Bruckheimer helped develop it. “Doctors deal with patients. Patients are built of tissues and things that move. If we want to intervene and treat those things, looking at them as they actually are in real life, in real time, is definitely going to improve the way we perform our procedures, how successful we are in those procedures and the time it takes to do those procedures,” Bruckheimer said. The system combines two technologies. Realview’s co-founder Shaul Gelman says it begins with data from X-ray, MRI or ultrasound imaging, reproduced as a 3D hologram. And for doctors like Einat Birk, that makes a difference. “Instead of having two dimensional cuts through the heart we are able to see the heart floating in front of us, we are able to cut through it, to touch it, to see the interaction between the device and the tissue around it. And it was really a wonderful, enlightening experience that we’re never exposed to,” Birk said. RealView says it plans to launch its medical imaging system commerically in 2015. Recent progress on holography allows us to understand how 3D holographic imaging technology works [1-6]. As explained by an Atlanta cardiologist Dr. Randy Martin [7] the heart is an extraordinary machine that he passionately talk about the anatomy and physiology of the heart. The addition of the holographic display in the operating room of a heart surgeon is giving to professionals in the field a new display tool that is continously perfected for the best care of humans and for the more understanding of many intricacies of the human heart.
1. V. M. Bove, “Display Holography’s Digital Second Act,” Proc. IEEE, 100, 4, 918–928 (2012).
2. H. I. Bjelkhagen and D. Brotherton-Ratcliffe, Ultra-Realistic Imaging: Advanced Techniques in Analogue and Digital Colour Holography, Taylor & Francis Group, London, England (2013).
3. J. Khan et al., “A low-resolution 3D holographic volumetric display,” Proc. SPIE, 7723, 77231B-7 (2010).
4. J. Khan et al., “A real-space interactive holographic display based on a large-aperture HOE,” Proc. SPIE, 8644, 86440M (2013).
5. http://www.laserfocusworld.com/articles/print/volume-49/issue-07/features/biomedical-imaging-3d-digital-holograms-visualize-biomedical-applications.html
6. http://www.digitalholography.eu/varasto/05709964.pdf
7. https://www.youtube.com/watch?v=nSEbAJFuoRo

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Technology Trends – Singularity Blog: Most Anticipated New Technologies for 2015/2016

Reporter: Aviva Lev-Ari, PhD, RN





Future timeline, a timeline of humanity’s future, based on current trends, long-term environmental changes, advances in technology such as Moore’s Law, the latest medical advances, and the evolving geopolitical landscape.


10TB solid state drives may soon be possibleConsumer virtual reality will grow exponentially 200GB microSD card announced by SanDisk”The Vive” – new VR headset being developed by HTC and ValveTesco becomes first UK retailer to launch a Google Glass-enabled serviceLaying the foundations for 5G mobileClothes that can monitor and transmit biomedical info3-D haptic shapes can be seen and felt in mid-airAI software can identify objects in photos and videos at near-human levelsDARPA circuit achieves speed of 1 terahertz (THz)3D printer which is 10 times faster than current modelsCreating DNA-based electrical circuitsWi-Fi up to five times faster coming in 2015Long-distance virtual telepathy is demonstratedThe Internet of Things: A Trillion Dollar MarketBrain-like supercomputer the size of a postage stampProject Adam: a new deep-learning system

Source: www.futuretimeline.net

See on Scoop.itCardiovascular and vascular imaging

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Quantum Physics Can Fight Fraud By Making Credit Card Verification Unspoofable


Reporter: Aviva Lev-Ari, PhD, RN


Decades of data security research have brought us highly reliable, standardized tools for common tasks such as digital signatures and encryption. But hackers are constantly working to crack data security innovations. Current credit/debit card technologies put personal money at risk because they’re vulnerable to fraud.


Physical security – which deals with anti-counterfeiting and the authentication of actual objects – is part of the problem too. The good guys and bad guys are locked in a never-ending arms race: one side develops objects and structures that are difficult to copy; the other side tries to copy them, and often succeeds.


But we think our new invention has the potential to leave the hackers behind. This innovative security measure uses the quantum properties of light to achieve fraud-proof authentication of objects.


The arms race is fought in secret; revealing your technology helps the enemy. Consequently, nobody knows how secure a technology really is. Remarkably, a recent development called Physical Unclonable Functions (PUFs) has made it possible to be completely open. A PUF is a piece of material that can be probed in many ways and that produces a complex response that depends very precisely on the challenge and the PUF’s internal structure.


The best known examples are Optical PUFs. The PUF is a piece of material – such as white paint with millions of nanoparticles – that will strongly scatter any light beamed at it. The light bounces around inside the paint, creating a unique pattern that can be used for authentication. Optical PUFs could be used on any object, but would be especially useful on credit/debit cards.


In 2012, researchers at Twente University realized they discovered something very important. The magic ingredient is a Spatial Light Modulator (SLM), a programmable device that re-shapes the speckle pattern. In their experiments, they programmed an SLM such that the correct response from an Optical PUF gets concentrated and passes through a pinhole, where a photon detector notices the presence of the photon. An incorrect response, however, is transformed to a random speckle pattern that does not pass through the pinhole. The method was dubbed Quantum-Secure Authentication (QSA).


QSA does not require any secrets, so no money has to be spent on protecting them. QSA can be implemented with relatively simple technology that is already available. The PUF can be as simple as a layer of paint. It turns out that the challenge does not have to be a single photon; a weak laser pulse suffices, as long as the number of photons in the pulse is small enough. Laser diodes, as found in CD players, are widely available and cheap. SLMs are already present in modern projectors. A sensitive photodiode or image sensor can serve as the photon detector. With all these advantages, QSA has the potential to massively improve the security of cards and other physical credentials.

Source: www.iflscience.com

See on Scoop.itCardiovascular Disease: PHARMACO-THERAPY

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