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Leaders in Pharmaceutical Business Intelligence Group, LLC, Doing Business As LPBI Group, Newton, MA

Healthcare analytics, AI solutions for biological big data, providing an AI platform for the biotech, life sciences, medical and pharmaceutical industries, as well as for related technological approaches, i.e., curation and text analysis with machine learning and other activities related to AI applications to these industries.

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NEW GENRE Genomics Volume Three, Results of Medical Text Analysis with Natural Language Processing (NLP) – Series B, Volume 3

View on Amazon.com

Results of Medical Text Analysis with Natural Language Processing (NLP): Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS

https://www.amazon.com/dp/B0BRD8JXTL

Results of Medical Text Analysis with Natural Language Processing (NLP): Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS & BioInformatics, … de la investigación genómica Book 3) Kindle Edition

by Madison Davis (Author), Aviva Lev-Ari (Editor), Stephen J. Williams (Editor), Marcus W. Feldman (Editor)  Format: Kindle Edition

Serie B: Fronteras de la investigación genómica 

(3 book series) Kindle Edition

by Larry H. Bernstein (Author) , Stephen J. Williams (Author) , Sudipta Saha (Author) , Ritu Saxena (Author) , Tilda Barliya (Author) , Anamika Sarkar (Author) , Marcus W. Feldman (Author) , Demet Sag (Author) , Prabodh kandala (Author) , Larry H. Bernstein (Author) , Aviva Lev-Ari (Author) , Madison Davis (Author)

https://www.amazon.com/dp/B0BQGZYZVT?binding=kindle_edition&ref=dbs_dp_rwt_sb_pc_tukn

 

  • NEW GENRE Volume Three: Results of Medical Text Analysis with Natural Language Processing (NLP).  It is known in 2022, as Genomics Volume Three in NEW GENRE Series B: Frontiers in Genomics Research

https://pharmaceuticalintelligence.com/audio-english-spanish-biomed-e-series/new-genre-audio-english-spanish-series-b-frontiers-in-genomics-research/genomics-volume-2-results-of-medical-text-analysis-with-natural-language-processing-nlp/

 

NEW GENRE Series B, Genomics Volume Three:

 

Results of Medical Text Analysis with

Natural Language Processing (NLP)

by 

Madison Davis

 

 

NLP Results Interpretation

by

Prof. Stephen J. Williams, Prof. Marcus W. Feldman and

Dr. Aviva Lev-Ari, PhD, RN

 

Leaders in Pharmaceutical Business Intelligence (LPBI) Group, Boston

Aviva Lev-Ari, PhD, RN,

Editor-in-Chief, BioMed E-Series and

NEW GENRE Audio English-Spanish BioMed e-Series

UC, Berkeley, PhD’83

avivalev-ari@alum.berkeley.edu

NEW GENRE Series B, Genomics Volume Three: was known as PART B in NEW GENRE Series B, Volume Two]. Now, it is Volume Three in the NEW GENRE BioMed e-Series, Series B.

 

The Original Text: Genomics VOLUME TWO

Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS & BioInformatics, Simulations and the Genome Ontology

Available on Amazon.com since 12/28/2019

https://www.amazon.com/dp/B08385KF87

 

In 2022, this original Book https://www.amazon.com/dp/B08385KF87

has two additional versions:

· New Genre Volume Two: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS and BioInformatics, Simulations and the Genome Ontology

· PART A (Spanish Audio, Bilingual Text) & PART C (English Audio)

https://pharmaceuticalintelligence.com/audio-english-spanish-biomed-e-series/new-genre-audio-english-spanish-series-b-frontiers-in-genomics-research/new-genre-volume-two-latest-in-genomics-methodologies-for-therapeutics-gene-editing-ngs-and-bioinformatics-simulations-and-the-genome-ontology-series-b-volume-2/

· NEW GENRE Volume Three: Results of Medical Text Analysis with Natural Language Processing (NLP).  It is known in 2022, as Genomics Volume Three in NEW GENRE Series B: Frontiers in Genomics Research. PART B in NEW GENRE Series B, Volume 3

· PART B (Graphics, English Text)

https://pharmaceuticalintelligence.com/audio-english-spanish-biomed-e-series/new-genre-audio-english-spanish-series-b-frontiers-in-genomics-research/genomics-volume-2-results-of-medical-text-analysis-with-natural-language-processing-nlp/

 

Serie B: Fronteras de la investigación genómica

 

Asesor de contenidos de la serie:

Larry H. Bernstein, MD, FCAP, Emeritus CSO, LPBI Group

2012 – 2017

 

Asesor de contenidos del volumen:

Prof. Marcus W. Feldman

2012 – Actualidad

https://www.youtube.com/watch?v=aT-Jb0lKVT8

BURNET C. Y MILDRED FINLEY WOHLFORD, PROFESORA EN LA SCHOOL OF HUMANITIES AND SCIENCES

Universidad de Stanford, codirectora del Center for Computational Evolutionary and Human Genetics

 

SEGUNDO VOLUMEN

 

Traducción a español

Montero Language Services

Lo último en metodologías genómicas para agentes terapéuticos:

edición génica, SMP y bioinformática,

simulaciones y la ontología del genoma


Prof. Marcus W. Feldman, PhD, Editor

Stephen J Williams, PhD, Editor

y

Aviva Lev-Ari, PhD, RN, Editor

 

Disponible en Amazon.com desde el 28/12/2019

https://www.amazon.com/dp/B08385KF87

Series B: Frontiers in Genomics Research

Series Content Consultant:

Larry H. Bernstein, MD, FCAP, Emeritus CSO, LPBI Group

2012 – 2017

Volume Content Consultant:

Prof. Marcus W. Feldman

2012 – Present

https://www.youtube.com/watch?v=aT-Jb0lKVT8

BURNET C. AND MILDRED FINLEY WOHLFORD PROFESSOR IN THE SCHOOL OF HUMANITIES AND SCIENCES

Stanford University, Co-Director, Center for Computational, Evolutionary and Human Genetics

 

VOLUME TWO

Latest in Genomics Methodologies for Therapeutics:

Gene Editing, NGS & BioInformatics,

Simulations and the Genome Ontology


Prof. Marcus W. Feldman, PhD, Editor

Stephen J Williams, PhD, Editor

and

Aviva Lev-Ari, PhD, RN, Editor

 

Available on Amazon.com since 12/28/2019

https://www.amazon.com/dp/B08385KF87

 

ENLACE a otros libros electrónicos sobre genómica en Amazon.com de nuestro equipo

Orientaciones genómicas para la medicina personalizada

PRIMER VOLUMEN

 

Traducción a español

Montero Language Services

 

LINK to other e-Books on Genomics on Amazon.com by Our Team

Genomics Orientations for Personalized Medicine

VOLUME ONE

  

En Amazon.com desde el 23/11/2015

http://www.amazon.com/dp/B018DHBUO6

Aviva Lev-Ari, PhD, RN

UC, Berkeley, PhD’83

Redactor jefe de la serie de libros electrónicos BioMed

Leaders in Pharmaceutical Business Intelligence (LPBI) Group,

Boston

avivalev-ari@alum.berkeley.edu

 

LPBI Group’s New Genre of Scientific Books

 

Genomics Volume 2, PART A:

 

Part A.1: electronic Table of Contents (eTOCs) in Spanish Audio

Part A.2: electronic Table of Contents (eTOCs) in Bilingual Spanish & English Test 

https://pharmaceuticalintelligence.com/audio-english-spanish-biomed-e-series/new-genre-audio-english-spanish-series-b-frontiers-in-genomics-research/new-genre-volume-two-latest-in-genomics-methodologies-for-therapeutics-gene-editing-ngs-and-bioinformatics-simulations-and-the-genome-ontology-series-b-volume-2/

  

This volume covers

only

Genomics Volume 3 was known as Volume 2, PART B

 

Results of Medical Text Analysis with

Natural Language Processing (NLP)

by

Madison Davis

 

NLP Results Interpretation

by

Prof. Stephen J. Williams, Prof. Marcus W. Feldman and

Dr. Aviva Lev-Ari, PhD, RN

   

Genomics Volume 2, PART C:  

Selective Editorials of the original text – English Audio

https://pharmaceuticalintelligence.com/audio-english-spanish-biomed-e-series/new-genre-audio-english-spanish-series-b-frontiers-in-genomics-research/new-genre-volume-two-latest-in-genomics-methodologies-for-therapeutics-gene-editing-ngs-and-bioinformatics-simulations-and-the-genome-ontology-series-b-volume-2/

 

Genomics Volume 3:

 

Results of Medical Text Analysis with

Natural Language Processing (NLP)

by

Madison Davis

 

 

NLP Results Interpretation

by

Prof. SJ Williams, Prof. MW Feldman and

Dr. Aviva Lev-Ari, PhD, RN

 

 Leaders in Pharmaceutical Business Intelligence (LPBI) Group, Boston

Aviva Lev-Ari, PhD, RN,

Editor-in-Chief, BioMed E-Series and

NEW GENRE Audio English-Spanish BioMed e-Series

UC, Berkeley, PhD’83

avivalev-ari@alum.berkeley.edu

NLP Software

 

WOLFRAM FUNCTION REPOSITORY

Instant-use add-on functions for the Wolfram Language

  •  HypergraphPlot – Plot a hypergraph defined by a list of hyperedges

https://resources.wolframcloud.com/FunctionRepository/resources/HypergraphPlot/

and

  •  TreePlot – Plot a tree diagram specified by edge rules

https://reference.wolfram.com/language/ref/TreePlot.html

 

Text Analysis with NLP of Original

Genomics Volume 2, Part 1:

Next Generation Sequencing (NGS)

 

1.1 The NGS Science

 

1.1.1 BioIT Aspect

  

Hypergraph Plot #1 and Tree Diagram #1

for 1.1.1 based on 16 articles & on 12 keywords

protein, cancer, dna, genes, rna, survival, immune,

tumor, patients, human, genome, expression

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 



List of articles included in 1.1.1

 

1.1.1.1   International Award for Human Genome Project

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2018/02/09/international-award-for-human-genome-project/

 

1.1.1.2   Cracking the Genome – Inside the Race to Unlock Human DNA – quotes in newspapers

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/11/20/cracking-the-genome-inside-the-race-to-unlock-human-dna-quotes-in-newspapers/

 

1.1.1.3   mRNA Data Survival Analysis

Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/06/18/mrna-data-survival-analysis/

 

1.1.1.4   Novel Discoveries in Molecular Biology and Biomedical Science

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/30/novel-discoveries-in-molecular-biology-and-biomedical-science/

 

1.1.1.5   Switching on genes

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/19/switching-on-genes/

 

1.1.1.6   The Role of Big Data in Medicine

Author: Gail S. Thornton, M.A.

https://pharmaceuticalintelligence.com/2016/05/16/the-role-of-big-data-in-medicine/

 

1.1.1.7   Disease related changes in proteomics, protein folding, protein-protein interaction

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/13/disease-related-changes-in-proteomics-protein-folding-protein-protein-interaction/

 

1.1.1.8   Bio-IT World 2016 – Reception with Dr. Howard Jacob – Aviva Lev-Ari, PhD, RN will attend

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/03/30/bio-it-world-2016-reception-with-dr-howard-jacob-aviva-lev-ari-phd-rn-will-attend/

 

1.1.1.9   How do we address medical diagnostic errors?

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/03/26/how-do-we-address-medical-diagnostic-errors/

 

1.1.1.10   DNA and Origami

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/03/17/dna-and-origami/

 

1.1.1.11   Phenotypic Screening must evolve to ensure successful Drug Development

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/03/10/phenotypic-screening-must-evolve-to-ensure-successful-drug-development/

 

1.1.1.12   3-D visualization of cancer cells

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/02/28/3-d-visualization-of-cancer-cells/

 

1.1.1.13   Leadership in Genomics: VarElect – Variants in Disease and UCSC Genome Technology Center

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/02/17/leadership-in-genomics-varelect-variants-in-disease-and-ucsc-genome-technology-center/

 

1.1.1.14   Signaling of Immune Response in Colon Cancer

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/09/signaling-of-immune-response-in-colon-cancer/

 

1.1.1.15   Periodic table of protein complexes

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/09/periodic-table-of-protein-complexes/

 

1.1.1.16   AGENDA for Oligonucleotide Therapeutics and Delivery, April 4-5, 2016, HYATT Hotel, Cambridge, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/12/03/agenda-for-oligonucleotide-therapeutics-and-delivery-april-4-5-2016-hyatt-hotel-cambridge-ma/

 

 

1.1.2   BioInformatics-NGS

 

Hypergraph Plot #2 and Tree Diagram #2

for 1.1.2 based on 17 articles & on 10 keywords

 

cancer, mutations, patients, disease, genetic, mutation,

clinical, tumor, genes, protein

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

 List of articles included in 1.1.2

 

1.1.2.1   Extracellular RNA and their carriers in disease diagnosis and therapy

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/05/04/extracellular-rna-and-their-carriers-in-disease-diagnosis-and-therapy/

 

1.1.2.2   Gender affects the prevalence of the cancer type

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/04/02/gender-affects-the-prevalence-of-the-cancer-type/

 

1.1.2.3    Pancreatic cancer survival is determined by ratio of two enzymes

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/03/29/pancreatic-cancer-survival-is-determined-by-ratio-of-two-enzymes/

 

1.1.2.4   Immuno-editing can be a constant defense in the cancer landscape

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/03/16/immunoediting-can-be-a-constant-defense-in-the-cancer-landscape/

 

1.1.2.5   Immunotherapy may help in glioblastoma survival

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/03/16/immunotherapy-may-help-in-glioblastoma-survival/

 

1.1.2.6   Knowing the genetic vulnerability of bladder cancer for therapeutic intervention

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2017/11/21/knowing-the-genetic-vulnerability-of-bladder-cancer-for-therapeutic-intervention/

 

1.1.2.7   SNP-based Study on high BMI exposure confirms CVD and DM Risks – no associations with Stroke

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/07/10/snp-based-study-on-high-bmi-exposure-confirms-cvd-and-dm-risks-no-associations-with-stroke/

 

1.1.2.8   Sperm Analysis by Smart Phone

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2017/03/29/sperm-analysis-by-smart-phone/

 

1.1.2.9   Dr. Doudna: RNA synthesis capabilities of Synthego’s team represent a significant leap forward for Synthetic Biology

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/01/04/dr-doudna-rna-synthesis-capabilities-of-synthegos-team-represent-a-significant-leap-forward-for-synthetic-biology/

 

1.1.2.10   Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics: Request for Book Review Writing on Amazon.com

Editors: Larry H. Bernstein and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/09/11/request-for-book-review-writing-on-amazon-com/

 

1.1.2.11   Cancer detection and therapeutics

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/02/cancer-detection-and-therapeutics/

 

1.1.2.12   Pull at Cancer’s Levers

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/02/pull-at-cancers-levers/

 

1.1.2.13   The world’s most innovative intersection

Reported by: Irina Robu

https://pharmaceuticalintelligence.com/2016/01/02/the-worlds-most-innovative-intersection/

 

1.1.2.14   Complex Cancer Genetics Testing

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/10/complex-cancer-genetics-testing/

 

1.1.2.15   The Need for an Informatics Solution in Translational Medicine

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/06/the-need-for-an-informatics-solution-in-translational-medicine/

 

1.1.2.16   Human Genetics and Childhood Diseases

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/03/human-genetics-and-childhood-diseases/

 

1.1.2.17   GEN Tech Focus: Rethinking Gene Expression Analysis

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/01/gen-tech-focus-rethinking-gene-expression-analysis/

 

 

1.1.3   Computation Biology

 

Hypergraph Plot #3 and Tree Diagram #3

for 1.1.3 based on 21 articles & on 8 keywords

 

protein, dna, cancer, cells, gene, sequence, chemical,

complexes

 

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 1.1.3

 

1.1.3.1   BioInformatic Resources at the Environmental Protection Agency: Tools and Webinars on Toxicity Prediction

Curator: Stephen J. Williams Ph.D.

https://pharmaceuticalintelligence.com/2019/05/11/bioinformatic-resources-at-the-environmental-protection-agency-tools-and-webinars-on-toxicity-prediction/

 

1.1.3.2   Live Conference Coverage @MedCity news Converge 2018 Philadelphia: Early Diagnosis Through Predictive Biomarkers, NonInvasive Testing

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2018/07/11/live-conference-coverage-medcitynews-converge-2018-philadelphia-early-diagnosis-through-predictive-biomarkers-noninvasive-testing/

 

1.1.3.3   DISCUSSION – Genomics-driven personalized medicine for Pancreatic Cancer

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/08/10/discussion-genomics-driven-personalized-medicine-for-pancreatic-cancer/

 

1.1.3.4   CancerBase.org – The Global HUB for Diagnoses, Genomes, Pathology Images: A Real-time Diagnosis and Therapy Mapping Service for Cancer Patients – Anonymized Medical Records accessible to anyone on Earth

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/28/cancerbase-org-the-global-hub-for-diagnoses-genomes-pathology-images-a-real-time-diagnosis-and-therapy-mapping-service-for-cancer-patients-anonymized-medical-records-accessible-to/

 

1.1.3.5   Innovative Gene Families for exploring patterns of Genetic Families applied by Craig Venter’s Team in Deeply Sequencing 10,500 Genomes: an average of 8,579 novel variants found per person –Intolerant sites, might be essential for life or health.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/19/innovative-gene-families-for-exploring-patterns-of-genetic-families-applied-by-craig-venters-team-in-deeply-sequencing-10500-genomes-an-average-of-8579-novel-variants-found-per-person-intoleran/

 

1.1.3.6   First challenge to make use of the new NCI Cloud Pilots – Somatic Mutation Challenge – RNA: Best algorithms for detecting all of the abnormal RNA molecules in a cancer cell

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/17/first-challenge-to-make-use-of-the-new-nci-cloud-pilots-somatic-mutation-challenge-rna-best-algorithms-for-detecting-all-of-the-abnormal-rna-molecules-in-a-cancer-cell/

 

1.1.3.7   Somatic Mutation Theory – Why it’s Wrong for Most Cancers

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/05/03/somatic-mutation-theory-why-its-wrong-for-most-cancers/

 

1.1.3.8   Genomics and epigenetics link to DNA structure

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/11/genomics-and-epigenetics-link-to-dna-structure

 

1.1.3.9   3-D molecular structures

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/02/28/3-d-molecular-structures/

 

 

1.1.3.10   Correspondence on Leadership in Genomics and other Gene Curations: Dr. Williams with Dr. Lev-Ari

Authors: Stephen J Williams, PhD and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/02/18/correspondence-on-leadership-in-genomics-and-other-gene-curations-dr-williams-dr-lev-ari/

 

1.1.3.11   Leadership in Genomics: VarElect – Variants in Disease and UCSC Genome Technology Center

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/02/17/leadership-in-genomics-varelect-variants-in-disease-and-ucsc-genome-technology-center/

 

1.1.3.12   Gene Editing for Exon 51: Why CRISPR Snipping might be better than Exon Skipping for DMD

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/23/gene-editing-for-exon-51-why-crispr-snipping-might-be-better-than-exon-skipping-for-dmd/

 

1.1.3.13   Periodic Table of Protein Complexes

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/09/periodic-table-of-protein-complexes/

 

1.1.3.14   Genomics’ Proprietary Statistical Analysis Tools and Integrated Multi-Phenotype Database to be used to Support Research and Development at Vertex Pharmaceuticals

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/04/genomics-proprietary-statistical-analysis-tools-and-integrated-multi-phenotype-database-to-be-used-to-support-research-and-development-at-vertex-pharmaceuticals/

 

1.1.3.15   N3xt generation carbon nanotubes

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/12/14/n3xt-generation-carbon-nanotubes/

 

1.1.3.16   Biochemistry and Dysmetabolism of Aging and Serious Illness

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/19/biochemistry-and-dysmetabolism-of-aging-and-serious-illness/

 

1.1.3.17   Identifying Cancers and Resistance

Curator: Larry H/ Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/18/identifying-cancers-and-resistance/

 

1.1.3.18   Complexity of Protein-Protein Interactions

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/12/protein-protein-interactions/

 

1.1.3.19   Variability of Gene Expression and Drug Resistance

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/12/variability-of-gene-expression-and-drug-resistance/

 

1.1.3.20   Sequence the Human Genome

Curator: Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/11/sequence-the-human-genome/

 

1.1.3.21   Single Nucleotide Repair and Tunable DNA-directed Assembly of Nanomaterials

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/01/single-nucleotide-repair-and-tunable-dna-directed-assembly-of-nanomaterials/

 

1.1.4   NGS – Discoveries in Medicine Derived from Advanced Sequencing

 

Hypergraph Plot #4 and Tree Diagram #4

for 1.1.4 based on 2 articles & on 11 keywords

 

sequencing, medicine, genes, women, genome, medical,

genetics, disorder, bipolar, autism, variations

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 
TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 1.1.4

 

1.1.4.1   Genomic relationship between autism and bipolar disorder

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/06/genomic-relationship-between-autism-and-bipolar-disorder/

 

1.1.4.2   Sequencing yourself! and Learn more on Genome Sequencing on Tuesday, November 17, 2015 from 8am-5pm in the Joseph B. Martin Conference Center of the Harvard New Research Building at Harvard Medical School

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/07/07/sequencing-yourself-and-learn-more-on-genome-sequencing-on-tuesday-november-17-2015-from-8am-5pm-in-the-joseph-b-martin-conference-center-of-the-harvard-new-research-building-at-harvard-medical-sc/

 

1.2 Technologies and Methodologies

 

1.2.1   BioIT

 

Hypergraph Plot #5 and Tree Diagram #5

for 1.2.1 based on 18 articles & on 9 keywords

 

cancer, cells, signature, genome, variants, gene, genomic,

human, features

 

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 1.2.1

 

1.2.1.1   A Nonlinear Methodology to Explain Complexity of the Genome and Bioinformatic Information

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/05/01/a-nonlinear-methodology-to-explain-complexity-of-the-genome-and-bioinformatic-information/

 

1.2.1.2   18th Annual 2019 BioIT, Conference & Expo, April 16-18, 2019, Boston, Seaport World Trade Center, Track 5 Next-Gen Sequencing Informatics – Advances in Large-Scale Computing

Real Time Coverage with Social Media: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/04/22/18th-annual-2019-bioit-conference-expo-april-16-18-2019-boston-seaport-world-trade-center-track-5-next-gen-sequencing-informatics-advances-in-large-scale-computing/

 

1.2.1.3   2019 Koch Institute Symposium – Machine Learning and Cancer, June 14, 2019, 8:00 AM-5:00 PM ET MIT Kresge Auditorium, 48 Massachusetts Ave, Cambridge, MA

Real Time Coverage with Social Media: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/03/12/2019-koch-institute-symposium-machine-learning-and-cancer-june-14-2019-800-am-500-pmet-mit-kresge-auditorium-48-massachusetts-ave-cambridge-ma/

 

1.2.1.4   Can Blockchain Technology and Artificial Intelligence Cure What Ails Biomedical Research and Healthcare

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2018/12/10/can-blockchain-technology-and-artificial-intelligence-cure-what-ails-biomedical-research-and-healthcare/

 

1.2.1.5   Bioinformatics Tool Review: Genome Variant Analysis Tools

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2018/10/23/bioinformatics-tool-review-genome-variant-analysis-tools/

 

1.2.1.6   2018 CHI’s BioIT World conference THURSDAY, MAY 17 | 8:00 – 9:45 AM – Awards and Keynote

Real Time Coverage with Social Media: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/05/17/2018-chis-bioit-world-conference-thursday-may-17-800-945-am-awards-and-keynote/

 

1.2.1.7   Vyasa Analytics Demos Deep Learning Software for Life Sciences at Bio-IT World 2018 – Vyasa’s booth (#632)

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/05/10/vyasa-analytics-demos-deep-learning-software-for-life-sciences-at-bio-it-world-2018-vyasas-booth-632/

 

1.2.1.8   Synopsis Track 7: NGS in Real Time @pharma_BI 2018 CHI’s BioIT World conference & Expo, May 15 – 17, 2018, Boston, MA – Seaport World Trade Center

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/04/05/2018-chis-bioit-world-conference-expo-may-15-17-2018-boston-ma-seaport-world-trade-center/

 

1.2.1.9   2017 Agenda – BioInformatics: Track 6: BioIT World Conference & Expo ’17, May 23-35, 2017, Seaport World Trade Center, Boston, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/01/12/2017-agenda-bioinformatics-track-6-bioit-world-conference-expo-17-may-23-35-2017-seaport-world-trade-center-boston-ma/

 

1.2.1.10   The 16th annual EmTech MIT – A Place of Inspiration, October 18-20, 2016, Cambridge, MA

Real Time coverage with Social Media: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/05/17/the-16th-annual-emtech-mit-a-place-of-inspiration-october-18-20-2016-cambridge-ma/

 

1.2.1.11   10 Most Successful Big Data Technologies

Guest Author: Gil Press

https://pharmaceuticalintelligence.com/2016/04/25/10-most-successful-big-data-technologies/

 

1.2.1.12   Big Data Self-Delusion

Guest Author: Gil Press

https://pharmaceuticalintelligence.com/2016/04/02/big-data-self-delusion/

 

1.2.1.13   Top 100 Big Data Experts to Follow

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/20/top-100-big-data-experts-to-follow/

 

1.2.1.14   Crystal Resolution in Raman Spetctoscopy for Pharmaceutical Analysis

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/20/crystal-resolution-in-raman-spectcroscopy-for-pharmaceutical-analysis/

 

1.2.1.15   Imaging of Cancer Cells

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/20/imaging-of-cancer-cells/

 

1.2.1.16   Bioinformatic Tools for Cancer Mutational Analysis: COSMIC and Beyond

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2015/12/02/bioinformatic-tools-for-cancer-mutational-analysis-cosmic-and-beyond-2/

 

1.2.1.17   Laboratory Automation Today

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/23/laboratory-automation-today/

 

1.2.1.18   Bioinformatics Tool Review: Genome Variant Analysis Tools

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2018/10/23/bioinformatics-tool-review-genome-variant-analysis-tools/

 

1.2.2   BioInformatics – NGS

 

Hypergraph Plot #6 and Tree Diagram #6

for 1.2.2 based on 18 articles & on 11 keywords

 

cancer, cells, drug, protein, human, bioinformatics, genes,

clinical, medicine, dna, genomics

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 
TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 1.2.2

 

1.2.2.1   A Nonlinear Methodology to Explain Complexity of the Genome and Bioinformatic Information

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/05/01/a-nonlinear-methodology-to-explain-complexity-of-the-genome-and-bioinformatic-information/

 

1.2.2.2   18th Annual 2019 BioIT, Conference & Expo, April 16-18, 2019, Boston, Seaport World Trade Center, Track 5 Next-Gen Sequencing Informatics – Advances in Large-Scale Computing

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/04/22/18th-annual-2019-bioit-conference-expo-april-16-18-2019-boston-seaport-world-trade-center-track-5-next-gen-sequencing-informatics-advances-in-large-scale-computing/

 

1.2.2.3   Thriving at the Survival Calls during Careers in the Digital Age – An AGE like no Other, also known as, DIGITAL

Author and Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/06/11/thriving-at-the-survival-calls-during-careers-in-the-digital-age-an-age-like-no-other-also-known-as-digital/

 

1.2.2.4   Synopsis Track 7: NGS in Real Time @pharma_BI 2018 CHI’s BioIT World conference & Expo, May 15 – 17, 2018, Boston, MA – Seaport World Trade Center

Real Time Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/04/05/2018-chis-bioit-world-conference-expo-may-15-17-2018-boston-ma-seaport-world-trade-center/

 

1.2.2.5   The BioPharma Industry’s Unrealized Wealth of Data, by Ben Szekely, Vice President, Cambridge Semantics

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/06/21/the-biopharma-industrys-unrealized-wealth-of-data-by-ben-szekely-vice-president-cambridge-semantics/

 

1.2.2.6   2017 Agenda – BioInformatics: Track 6: BioIT World Conference & Expo ’17, May 23-35, 2017, Seaport World Trade Center, Boston, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/01/12/2017-agenda-bioinformatics-track-6-bioit-world-conference-expo-17-may-23-35-2017-seaport-world-trade-center-boston-ma/

 

1.2.2.7   A novel 5-gene pancreatic adenocarcinoma classifier: Meta-analysis of transcriptome data – Clinical Genomics Research @BIDMC

Curator: Tilda Barliya, PhD

https://pharmaceuticalintelligence.com/2016/12/28/a-novel-5-gene-pancreatic-adenocarcinoma-classifier-meta-analysis-of-transcriptome-data-clinical-genomics-research-bidmc/

 

1.2.2.8   Recap of Bio-IT World 2016 by Sanjay Joshi  CTO, Healthcare & Life Sciences, EMC Emerging Technologies Division

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/04/21/recap-of-bio-it-world-2016-by-sanjay-joshi-cto-healthcare-life-sciences-emc-emerging-technologies-division/

 

1.2.2.9   Genome Analysis Toolkit (GATK) the Industry Standard will govern the New Tools in Biomedical Research by the Collaboration of Broad Institute and Intel

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/04/06/genome-analysis-toolkit-gatk-the-industry-standard-will-govern-the-new-tools-in-biomedical-research-by-the-collaboration-of-broad-institute-and-intel/

 

1.2.2.10   Curbing Cancer Cell Growth & Metastasis-on-a-Chip’ Models Cancer’s Spread

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/03/19/curbing-cancer-cell-growth/

 

1.2.2.11   Simulation of DNA Sequencing through Graphene Nanopore

Reporter: Danut Dragoi, PhD

https://pharmaceuticalintelligence.com/2016/01/26/simulation-of-dna-sequencing-through-graphene-nanopore/

 

1.2.2.12   2016 BioIT World: Track 5 – April 5 – 7, 2016 Bioinformatics Computational Resources and Tools to Turn Big Data into Smart Data

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/11/30/2016-bioit-world-track-5-april-5-7-2016-bioinformatics-computational-resources-and-tools-to-turn-big-data-into-smart-data/

 

1.2.2.13   Biomarker Development

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/16/biomarker-development/

 

1.2.2.14   Genetically Engineered Algae

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/15/genetically-engineered-algae/

 

1.2.2.15   Sequence the Human Genome

Curator: Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/11/sequence-the-human-genome/

 

1.2.2.16   Atul Butte TALK on YouTube on Big Data, Open Data and Clinical Trials

Reporter: Aviva Lev-Ari, PhD

https://pharmaceuticalintelligence.com/2015/10/17/atul-butte-talks-on-big-data-open-data-and-clinical-trials/

 

1.2.2.17   How to identify Genes associated with Genetic Diseases and Cancer: A Phylogenetic Profiling Evolutionary Approach @ HUJI

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/07/16/how-to-identify-genes-associated-with-genetic-diseases-and-cancer-a-phylogenetic-profiling-evolutionary-approach-huij/

 

1.2.2.18   Tweets by @pharma_BI at 2015 BioIT, Boston, 4/21/2015- 4/23/2015

Live Press Coverage: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/05/12/tweets-by-pharma_bi-at-2015-bioit-boston-4212015-4232015/

 

 

1.2.3   Computation Biology

 

Hypergraph Plot #7 and Tree Diagram #7

for 1.2.3 based on 11 articles & on 11 keywords

 

dna, cancer, protein, gene, search, amino, health, medicine,

cells, genome, editing

 

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 
TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 1.2.3

 

1.2.3.1   A New Computational Method illuminates the Heterogeneity and Evolutionary Histories of cells within a Tumor

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/08/11/a-new-computational-method-illuminates-the-heterogeneity-and-evolutionary-histories-of-cells-within-a-tumor/

 

1.2.3.2   Through Data Science: Stanford Medicine and Google will transform Patient Care and Medical Research

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/08/09/through-data-science-and-cloud-technology-stanford-medicine-and-google-will-transform-patient-care-and-medical-research/

 

1.2.3.3   A New Potential Target for Pancreatic Cancer Treatment: Rapid Screening Technique finds Gene Defending Tumors from DNA Damage @M. D. Anderson Cancer Center

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/28/a-new-potential-target-for-pancreatic-cancer-treatment-rapid-screening-technique-finds-gene-defending-tumors-from-dna-damage-md-anderson-cancer-center/

 

1.2.3.4   Deep Learning for In-silico Drug Discovery and Drug Repurposing: Artificial Intelligence to search for molecules boosting response rates in Cancer Immunotherapy: Insilico Medicine @John Hopkins University

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/17/deep-learning-for-in-silico-drug-discovery-and-drug-repurposing-artificial-intelligence-to-search-for-molecules-boosting-response-rates-in-cancer-immunotherapy-insilico-medicine-john-hopkins-univer/

 

1.2.3.5   Gene Editing: The Role of Oligonucleotide Chips

Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/07/gene-editing-the-role-of-oligonucleotide-chips/

 

1.2.3.6   How Will FDA’s new precision FDA Science 2.0 Collaboration Platform Protect Data?

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2015/12/16/how-will-fdas-new-precisionfda-science2-0-collaboration-platform-protect-data/

 

1.2.3.7   Computer Aided Design

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/17/computer-aided-design/

 

1.2.3.8   Genomic Pathogen Typing

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/16/genomic-pathogen-typing/

 

1.2.3.9   Best Big Data?

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/16/best-big-data/

 

1.2.3.10   Better Bioinformatics

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/09/better-bioinformatics/

 

1.2.3.11   Healthcare conglomeration to access Big Data and lower costs

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/13/healthcare-conglomeration-to-access-big-data-and-lower-costs/

 

1.2.4   NGS – Discoveries Driven by Advanced Sequencing

 

Hypergraph Plot #8 and Tree Diagram #8

for 1.2.4 based on 5 articles & on 10 keywords

 

genetic, sequencing, gene, clinical, genome, reproductive,

disease, diagnostics, medicine, ngs

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 1.2.4

 

1.2.4.1   Crowdsourcing Genetic Data Yields Discovery of DNA loci associated with Major Depressive Disorder (MDD) in European Descendants

Reporter: Kelly Perlman, Life Sciences Student and Research Assistant, McGill University

https://pharmaceuticalintelligence.com/2016/08/09/crowdsourcing-genetic-data-yields-discovery-of-dna-loci-associated-with-mdd-in-european-descendants/

 

1.2.4.2   Using Online Mendelian Inheritance in Man (OMIM) database and the Human Genome Mutation Database (HGMD) Pro 2015.2 for Quantification of the growth in gene-disease and variant-disease associations

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/22/using-online-mendelian-inheritance-in-man-omim-database-and-the-human-genome-mutation-database-hgmd-pro-2015-2-for-quantification-of-the-growth-in-gene-disease-and-variant-disease-associations/

 

1.2.4.3   Roche is developing a high-throughput low cost sequencer for NGS, How NGS Will Revolutionize Reproductive Diagnostics: November Meeting, Boston MA

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2015/12/16/roche-is-developing-a-high-throughput-low-cost-sequencer-for-ngs/

 

1.2.4.4   How NGS Will Revolutionize Reproductive Diagnostics: November Meeting, Boston MA

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2015/09/10/how-ngs-will-revolutionize-reproductive-diagnostics-november-meeting-boston-ma/

 

1.2.4.5   LIVE Plenary Session 2015 BioIT, April 21, 2015, 4:00 – 5:00PM – Cambridge HealthTech Institute’s 14th Annual Meeting BioIT World – Conference & Expo ’15, April 21 – 23, 2015 @Seaport World Trade Center, Boston, MA

Real Time Reporter: Dr. Aviva Lev-Ari will be in attendance on April 21, 22, 23

https://pharmaceuticalintelligence.com/2015/04/21/live-plenary-session-2015-bioit-april-21-2015-400-500pm-cambridge-healthtech-institutes-14th-annual-meeting-bioit-world-conference-expo-15-april-21/

 

1.3 NGS – Clinical Aspects

 

Hypergraph Plot #9 and Tree Diagram #9

for 1.3 based on 11 articles & on 14 keywords

 

cells, medicine, cancer, clinical, gene, medical, patients,

sequencing, health, therapy, pharma, drug, genetic, genome

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

 

1.3.1 BioInformatics – NGS

List of articles included in 1.3.1

 

1.3.1.1   Translation of whole human genome sequencing to clinical practice: The Joint Initiative for Metrology in Biology (JIMB) is a collaboration between the National Institute of Standards & Technology (NIST) and Stanford University.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/12/18/translation-of-whole-human-genome-sequencing-to-clinical-practice-the-joint-initiative-for-metrology-in-biology-jimb-is-a-collaboration-between-nist-and-stanford-university/

 

1.3.1.2   Transparency in Clinical Trials

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/09/transparency-in-clinical-trials/

1.3.2   Computation Biology & NGS

 

List of articles included in 1.3.2

 

1.3.2.1   Topical Solution for Combination Oncology Drug Therapy: Patch that delivers Drug, Gene, and Light-based Therapy to Tumor

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/27/topical-solution-for-combination-oncology-drug-therapy-patch-that-delivers-drug-gene-and-light-based-therapy-to-tumor/

 

1.3.3   NGS – Clinical Aspects

 

List of articles included in 1.3.3

 

1.3.3.1   New NGS Guidances for Laboratory Developed Tests (LDT): FDA’s Liz Mansfield on Audio Podcast

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/19/new-ngs-guidances-fdas-liz-mansfield-on-audio-podcast/

 

1.3.3.2   Next Generation Sequencing in Clinical Laboratory

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/03/22/next-generation-sequencing-in-clinical-laboratory/

 

1.3.3.3    First Cost-Effectiveness Study of Multi-Gene Panel Sequencing in Advanced Non-Small Cell Lung Cancer Shows Moderate Cost-Effectiveness, Exposes Crucial Practice Gap

Guest Author: Press Release by Personalized Medicine Coalition

https://pharmaceuticalintelligence.com/2019/06/27/first-cost-effectiveness-study-of-multi-gene-panel-sequencing-in-advanced-non-small-cell-lung-cancer-shows-moderate-cost-effectiveness-exposes-crucial-practice-gap/

 

1.3.3.4   2019 Warren Alpert Foundation Award goes to Four Scientists for Seminal Discoveries in OptoGenetics – Illuminating the Human Brain

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/18/2019-warren-alpert-foundation-award-goes-to-four-scientists-for-seminal-discoveries-in-optogenetics-illuminating-the-human-brain/

 

1.3.3.5   Broad@15 – In 2004, the Broad Institute of MIT and Harvard launched with a mission to improve human health

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/31/broad15-in-2004-the-broad-institute-of-mit-and-harvard-launched-with-a-mission-to-improve-human-health/

  

1.3.3.6   New Mutant KRAS Inhibitors Are Showing Promise in Cancer Clinical Trials: Hope For the Once ‘Undruggable’ Target

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/11/11/new-mutant-kras-inhibitors-are-showing-promise-in-cancer-clinical-trials-hope-for-the-once-undruggable-target/

 

1.3.3.7   eProceedings 15th Annual Personalized Medicine Conference at Harvard Medical School – THE PARADIGM EVOLVES, November 13 – 14, 2019 • Harvard Medical School, Boston, MA

Real Time Press Coverage: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/19/15th-annual-personalized-medicine-conference-at-harvard-medical-school-the-paradigm-evolves-november-13-14-2019-%e2%80%a2-harvard-medical-school-boston-ma/

 

1.3.3.8   Tweets and Retweets by @AVIVA1950 and by @pharma_BI for 15th Annual Personalized Medicine Conference at Harvard Medical School – THE PARADIGM EVOLVES, November 13 – 14, 2019 • Harvard Medical School, Boston, MA

Real Time Press Coverage: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/11/15/tweets-and-retweets-by-aviva1950-and-by-pharma_bi-for-15th-annual-personalized-medicine-conference-at-harvard-medical-school-the-paradigm-evolves-november-13-14-2019-%e2%80%a2/

  

1.3.3.9   Complex rearrangements and oncogene amplification revealed by long-read DNA and RNA sequencing of a breast cancer cell line

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2019/08/14/complex-rearrangements-and-oncogene-amplification-revealed-by-long-read-dna-and-rna-sequencing-of-a-breast-cancer-cell-line/

  

1.3.3.10   eProceedings – Day 1: Charles River Laboratories – 3rd World Congress, Delivering Therapies to the Clinic Faster, September 23 – 24, 2019, 25 Edwin H. Land Boulevard, Cambridge, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/19/charles-river-laboratories-world-congress-delivering-therapies-to-the-clinic-faster-september-23-24-2019-cambridge-ma/

 

1.3.3.11 Genetic Testing in CVD and Precision Medicine

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/12/16/genetic-testing-in-cvd-and-precision-medicine/

 

1.4 Business and Legal

 

Hypergraph Plot #10 and Tree Diagram #10

for 1.4 based on 18 articles & on 10 keywords

 

oncology, healthcare, cancer, data, cells, sequencing, health,

life, gene, AI

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

 

1.4.1   BioIT

 

List of articles included in 1.4.1

 

1.4.1.1   Japan’s National Cancer Center Adopts Qiagen Bioinformatics Platform for Precision Med Program

https://www.genomeweb.com/informatics/japans-national-cancer-center-adopts-qiagen-bioinformatics-platform-precision-med?utm_source=Sailthru&utm_medium=email&utm_campaign=GW%20Infx%20Wed%202019-06-19&utm_term=Informatics%20Bulletin#.XQqfntNKhhA

 

1.4.1.2   37th Annual J.P. Morgan HEALTHCARE CONFERENCE: #JPM2019 for Jan. 8, 2019; Opening Videos, Novartis expands Cell Therapies, January 7 – 10, 2019, Westin St. Francis Hotel | San Francisco, California

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2019/01/08/37th-annual-j-p-morgan-healthcare-conference-jpm2019-for-jan-8-2019-opening-videos-novartis-expands-cell-therapies/

 

1.4.1.3   Healthcare conglomeration to access Big Data and lower costs

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/13/healthcare-conglomeration-to-access-big-data-and-lower-costs/

 

1.4.1.4   Future of Big Data for Societal Transformation

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/12/14/future-of-big-data-for-societal-transformation/

 

1.4.1.5   Avvinity will have exclusive rights in oncology to use Alphamer therapeutic platform, invented by a Nobel Laureate and developed by Centauri: A Case of a Joint Venture Model

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/03/02/avvinity-will-have-exclusive-rights-in-oncology-to-use-alphamer-therapeutic-platform-invented-by-a-nobel-laureate-and-developed-by-centauri-a-case-of-a-joint-venture-model/

1.4.2   Bioinformatics – NGS

 

List of articles included in 1.4.2

 

1.4.2.1   Role of Informatics in Precision Medicine: Notes from Boston Healthcare Webinar: Can It Drive the Next Cost Efficiencies in Oncology Care?

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/01/03/role-of-informatics-in-precision-medicine-can-it-drive-the-next-cost-efficiencies-in-oncology-care/

 

1.4.2.2   TSUNAMI in HealthCare under the New Name Verily.com

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/12/14/tsunami-in-healthcare-under-the-new-name-verily-com/

 

1.4.3   Computation Biology

 

List of articles included in 1.4.3

 

1.4.3.1   Convergence of Biology, Medicine, and Computing: Biomedical Informatics Entrepreneurs Salon (BIES), HMS, 2/7/19, 4:30 – 6:30PM

Real Time Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/01/23/convergence-of-biology-medicine-and-computing-biomedical-informatics-entrepreneurs-salon-bies-hms-2-7-19-430-630pm/

 

1.4.3.2   On its way for an IPO: mRNA platform, Moderna, Immune Oncology is recruiting 100 new Life Scientists in Cambridge, MA

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/09/07/on-its-way-for-an-ipo-mrna-platform-immune-oncology-is-recruiting-100-new-life-scientists-in-cambridge-ma/

 

1.4.3.3    #JPM19 Conference: Lilly Announces Agreement To Acquire Loxo Oncology

Reporter: Gail S. Thornton

https://pharmaceuticalintelligence.com/2019/01/08/jpm19-conference-lilly-announces-agreement-to-acquire-loxo-oncology/

 

1.4.3.4   JP Morgan Healthcare Day Two: Thermo Fisher; Qiagen; Danaher; Counsyl; Human Longevity; Adaptive Bio, 10X Genomics and Pacific Biosciences

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/13/jp-morgan-healthcare-day-two-thermo-fisher-qiagen-danaher-counsyl-human-longevity-adaptive-bio-10x-genomics-and-pacific-biosciences/

 

1.4.3.5   Day One at #JPM16: Breakout sessions of 23andMe, Myriad Genetics, Genomic Health, and Alere

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/12/day-one-at-jpm16-breakout-sessions-of-23andme-myriad-genetics-genomic-health-and-alere/

 

1.4.3.6   #JPM16: Illumina’s CEO on new genotyping array called Infinium XT and Bio-Rad Partnership for single-cell sequencing workflow

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/12/jpm16-illuminas-ceo-on-new-genotyping-array-called-infinium-xt-and-bio-rad-partnership-for-single-cell-sequencing-workflow/

 

1.4.3.7   Juno Acquires AbVitro for $125M: high-throughput and single-cell sequencing capabilities for Immune-Oncology Drug Discovery

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/12/juno-acquires-abvitro-for-125m-high-throughput-and-single-cell-sequencing-capabilities-for-immune-oncology-drug-discovery/

 

1.4.3.8   #JPM16: Illumina’s CEO on new genotyping array called Infinium XT and Bio-Rad Partnership for single-cell sequencing workflow

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/12/jpm16-illuminas-ceo-on-new-genotyping-array-called-infinium-xt-and-bio-rad-partnership-for-single-cell-sequencing-workflow/

 

1.4.4   NGS

 

List of articles included in 1.4.4

 

1.4.4.1   QIAGEN – International Leader in NGS and RNA Sequencing

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/10/08/qiagen-international-leader-in-ngs-and-rna-sequencing/

 

1.4.4.2   Four patents and one patent application on Nanopore Sequencing and methods of trapping a molecule in a nanopore assigned to Genia, is been claimed in a Law Suit by The Regents of the University of California, should be assigned to UCSC

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/01/05/four-patents-and-one-patent-application-on-nanopore-sequencing-and-methods-of-trapping-a-molecule-in-a-nanopore-assigned-to-genia-is-been-claimed-in-a-law-suit-by-the-regents-of-the-university-of-cal/

 

1.4.4.3   Invivoscribe, Thermo Fisher Ink Cancer Dx Development Deal

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2016/04/16/invivoscribe-thermo-fisher-ink-cancer-dx-development-deal/

 

Text Analysis with NLP of the Original

Genomics Volume 2, Part 2:

CRISPR for Gene Editing and DNA Repair

2.1 CRISPR – Aspects of the Science

 

2.1.1 Basic Biochemical Issues

 

Hypergraph Plot #11 and Tree Diagram #11

for 2.1.1 based on 22 articles & on 14 keywords

 

cells, crispr, cas, gene, beta, dna, protein, editing, genome,

cancer, target, ripk, rna, expression

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 2.1.1

 

2.1.1.1   Breakthrough in Gene Editing CRISPR–Cas systems: First example of a fully programmable, RNA-guided integrase and lays the foundation for genomic manipulations that obviate the requirements for double-strand breaks and homology-directed repair.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/06/13/breakthrough-in-gene-editing-crispr-cas-systems-first-example-of-a-fully-programmable-rna-guided-integrase-and-lays-the-foundation-for-genomic-manipulations-that-obviate-the-requirements-for/

 

2.1.1.2   Alternative to CRISPR/Cas9 – CAST (CRISPR-associated transposase) – A New Gene-editing Approach for Insertion of Large DNA Sequences into a Genome developed @BroadInstitute @MIT @Harvard

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/06/11/alternative-to-crispr-cas9-cast-crispr-associated-transposase-a-new-gene-editing-approach-for-insertion-of-large-dna-sequences-into-a-genome-developed-broadinstitute-mit-harvard/

 

2.1.1.3   Innovations on the CRISPR System for Gene Editing: (1) Cryo-electron microscopy-based visualization of Cas3 Enzyme Cleavage (2) New tool testing an entire genome against a CRISPR molecule to predict potential errors and interactions

Curator and Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/07/03/innovations-on-the-crispr-system-for-gene-editing-1-cryo-electron-microscopy-based-visualization-of-cas3-enzyme-cleavage-2-new-tool-testing-an-entire-genome-against-a-crispr-molecule-to-pred/

 

2.1.1.4   Researchers at Dana-Farber/Boston Children’s: Differences in wiring of “exhausted” and effective T cells indicate possible gene-editing targets

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/10/31/researchers-at-dana-farberboston-childrens-differences-in-wiring-of-exhausted-and-effective-t-cells-indicate-possible-gene-editing-targets/

 

2.1.1.5   “CRISPR-Cas9, bring me a gene”, Encoding for a specific protein: Three words: CRISPR. A Capella

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/10/13/crispr-cas9-bring-me-a-gene-encoding-for-a-specific-protein-three-words-crispr-a-capella/

 

2.1.1.6   Novel Discoveries in Molecular Biology and Biomedical Science

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/30/novel-discoveries-in-molecular-biology-and-biomedical-science/

 

2.1.1.7   A Genetic Switch to Control Female Sexual Behavior

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2016/05/16/a-genetic-switch-to-control-female-sexual-behavior/

 

2.1.1.8   Preliminary Agenda Available and Exclusive Discount to attend Understanding CRISPR: Mechanisms to Applications Symposium in Boston (September 19, 2016)

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/05/12/preliminary-agenda-available-and-exclusive-discount-to-attend-understanding-crispr-mechanisms-to-applications-symposium-in-boston-september-19-2016/

 

2.1.1.9   Gene Editing with CRISPR gets Crisper

Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/05/03/gene-editing-with-crispr-gets-crisper/

 

2.1.1.10   CRISPR-Cas9 Screening by Horizon Discovery, Cambridge, UK – HDx™ Reference Standards

Reporters: David Orchard-Webb, PhD and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/05/03/crispr-cas9-screening-by-horizon-cambridge-uk-hdx-reference-standards/

 

2.1.1.11   Recent Progress in Gene Editing Error Reduction

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/21/recent-progress-in-gene-editing-error-reduction/

 

2.1.1.12   CRISPR/Cas9 and HIV1

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/16/crisprcas9-and-hiv1/

 

2.1.1.13   Rice University researches develop new CRISPR-CAS9 strategy to reduce off-target gene editing effects

Reporter: Stephen J. Williams

https://pharmaceuticalintelligence.com/2016/03/22/rice-university-researches-develop-new-crispr-cas9-strategy-to-reduce-off-target-gene-editing-effects/

 

2.1.1.14   @MIT: New delivery method boosts efficiency of CRISPR genome-editing system

Reporters: Aviva Lev-Ari, PhD, RN and Stephen J Williams, PhD

https://pharmaceuticalintelligence.com/2016/02/08/mit-new-delivery-method-boosts-efficiency-of-crispr-genome-editing-system/

 

2.1.1.15   Alternative CRISPR discovered @MIT

Reporter: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/02/15/alternative-crispr-discovered/

 

2.1.1.16   Shortened Time for Cell Renewal

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/12/15/shortened-time-for-cell-renewal/

 

2.1.1.17   Turning CRISPR/Cas9 On or Off

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/21/turning-crisprcas9-on-or-off/

 

2.1.1.18   Cell Death Pathway Insights

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/09/cell-death-pathway-insights/

 

2.1.1.19   Gene Silencing

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/05/gene-silencing/

 

2.1.1.20   New CRISPR-non Cas9 proteins

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/10/27/new-crispr-non-cas9-proteins/

 

2.1.1.21   Regulatory DNA Engineered

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/02/11/regulatory-dna-engineered/

 

2.1.1.22    At Technical University of Munich (TUM) Successful Genetical modification of a patient’s own immune cells, T cell receptors, using CRISPR-Cas9 gene editing tool. The engineered T cells are very similar to the physiological immune cells.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/17/at-technical-university-of-munich-tum-successful-genetical-modification-of-a-patients-own-immune-cells-t-cell-receptors-using-crispr-cas9-gene-editing-tool-the-engineered-t-cells-are-ver/

 

2.1.2 Drug Discovery

 

Hypergraph Plot #12 and Tree Diagram #12

for 2.1.2 based on 8 articles & on 14 keywords

 

crispr, cas, cells, genome, dna, genes, rna, protein, genetic,

editing, disease, target, human, technology

 

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 2.1.2

 

2.1.2.1   CRISPR/Cas9 Finds Its Way As an Important Tool For Drug Discovery & Development

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2015/09/02/crisprcas9-finds-its-way-as-an-important-tool-for-drug-discovery-development/

 

2.1.2.2   Delineating a Role for CRISPR-Cas9 in Pharmaceutical Targeting

Author & Curator: Larry H. Bernstein, MD, FCAP, Chief Scientific Officer, Leaders in Pharmaceutical Intelligence (LPBI) Group, Boston, MA

https://pharmaceuticalintelligence.com/2015/08/30/delineating-a-role-for-crispr-cas9-in-pharmaceutical-targeting/

 

2.1.2.3   Where is the most promising avenue to success in Pharmaceuticals with CRISPR-Cas9?

Author: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/09/01/where-is-the-most-promising-avenue-to-success-in-pharmaceuticals-with-crispr-cas9/

 

2.1.2.4   Use of CRISPR & RNAi for Drug Discovery, CHI’s World PreClinical Congress – Europe, November 14-15, 2016, Lisbon, Portugal

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/05/24/chis-world-preclinical-congress-europe-november-14-15-2016-lisbon-portugal-use-of-crispr-rnai-for-drug-discovery/

 

2.1.2.5   2nd Annual Translational Gene Editing: Exploiting CRISPR/Cas9 for Building Tools for Drug Discovery & Development: June 16, 2016, Boston, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/03/30/2nd-annual-translational-gene-editing-exploiting-crisprcas9-for-building-tools-for-drug-discovery-development-june-16-2016boston-ma/

 

2.1.2.6   Intestinal Inflammatory Pharmaceutics

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/02/11/intestinal-inflammatory-pharmaceutics/

 

2.1.2.7   Disease Disablers

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/23/disease-disablers/

 

2.1.2.8   Gene-Silencing and Gene-Disabling in Pharmaceutical Development

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/19/gene-silencing-and-gene-disabling-in-pharmaceutical-development/

 

2.1.3 CRISPR as a Therapeutics Modality

 

Hypergraph Plot #13 and Tree Diagram #13

for 2.1.3 based on 15 articles & on 14 keywords

 

crispr, cas, protein, cells, genome, editing, dna, rna, disease,

genes, cancer, human, target, technology

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

 

List of articles included in 2.1.3

 

2.1.3.1   UPDATED – Medical Interpretation of the Genomics Frontier – CRISPR – Cas9:  Gene Editing Technology for New Therapeutics

Authors and Curators: Larry H Bernstein, MD, FCAP and Stephen J Williams, PhD and Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/09/07/medical-interpretation-of-the-genomics-frontier-crispr-cas9-gene-editing-technology-for-new-therapeutics/

 

2.1.3.2   Advances in Gene Editing Technology: New Gene Therapy Options in Personalized Medicine

Curators: Stephen J Williams, PhD and Aviva Lev-Ari, PhD, RN

Recent Advances in Gene Editing Technology Adds New Therapeutic Potential for the Genomic Era

Author and Curator: Stephen J Williams, PhD

https://pharmaceuticalintelligence.com/2015/03/16/advances-in-gene-editing-technology-new-gene-therapy-options-in-personalized-medicine/

 

2.1.3.3   People with two copies of the Δ32 mutation died at rates 21 percent higher than those with one or no copies – application of CRISPR @Berkeley

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/06/03/people-with-two-copies-of-the-%CE%B432-mutation-died-at-rates-21-percent-higher-than-those-with-one-or-no-copies/

 

2.1.3.4   TWEETS by @pharma_BI and @AVIVA1950 at #IESYMPOSIUM – @kochinstitute 2019 #Immune #Engineering #Symposium, 1/28/2019 – 1/29/2019

Real Time Press Coverage: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/01/31/tweets-by-pharma_bi-and-aviva1950-at-iesymposium-kochinstitute-2019-immune-engineering-symposium-1-28-2019-1-29-2019/

 

2.1.3.5   Jennifer Doudna and NPR science correspondent Joe Palca, several interviews

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/11/26/jennifer-doudna-and-npr-science-correspondent-joe-palca-several-interviews/

 

2.1.3.6   Original Tweets Re-Tweets and Likes by @pharma_BI and @AVIVA1950 at #kisymposium for 17th annual Summer Symposium: Breakthrough Cancer Nanotechnologies: Koch Institute, MIT Kresge Auditorium, June 15, 2018, 9AM-4PM

Real Time Press Coverage: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/06/17/original-tweets-re-tweets-and-likes-by-pharma_bi-and-aviva1950-at-kisymposium-for-17th-annual-summer-symposium-breakthrough-cancer-nanotechnologies-koch-institute-mit-kresge-auditorium-june-15/

 

2.1.3.7   Lysyl Oxidase (LOX) gene missense mutation causes Thoracic Aortic Aneurysm and Dissection (TAAD) in Humans because of inadequate cross-linking of collagen and elastin in the aortic wall – Mutation carriers may be predisposed to vascular diseases because of weakened vessel walls under stress conditions.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/19/lysyl-oxidase-lox-gene-missense-mutation-causes-thoracic-aortic-aneurysm-and-dissection-taad-in-humans-because-of-inadequate-cross-linking-of-collagen-and-elastin-in-the-aortic-wall/

 

2.1.3.8   AACR2016 – Cancer immunotherapy

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/19/aacr2016-cancer-immunotherapy/

 

2.1.3.9   CRISPR/Cas9, Familial Amyloid Polyneuropathy (FAP) and Neurodegenerative Disease

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/17/crisprcas9-fap-and-neurodegenerative-disease/

 

2.1.3.10   Can CRISPR/Cas9 Target Multiple Targets?

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/22/can-crisprcas9-target-multiple-targets/

 

2.1.3.11   Genomic Pathogen Typing

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/16/genomic-pathogen-typing/

 

2.1.3.12   Breaking News about Genomic Engineering, T2DM and Cancer Treatments – 9/28/2015

Curator: Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/09/28/breaking-news-about-genomic-engineering-t2dm-and-cancer-treatments/

 

2.1.3.13   Disease related changes in proteomics, protein folding, protein-protein interaction

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/13/disease-related-changes-in-proteomics-protein-folding-protein-protein-interaction/

 

2.1.3.14   @BroadInstitute a shift from Permanently editing DNA to Temporarily revising RNA – An approach with promise for addressing the risk of developing Alzheimer’s by deactivating APOE4 – RESCUE: RNA Editing for Specific C to U Exchange, the platform builds on REPAIR: RNA Editing for Programmable A to I

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/12/broadinstitute-a-shift-from-permanently-editing-dna-to-temporarily-revising-rna-an-approach-with-promise-for-addressing-the-risk-of-developing-alzheimers-by-deactivating-apoe4-rescue-rn/

  

2.1.3.15  At Technical University of Munich (TUM) Successful Genetical modification of a patient’s own immune cells, T cell receptors, using CRISPR-Cas9 gene editing tool. The engineered T cells are very similar to the physiological immune cells.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/17/at-technical-university-of-munich-tum-successful-genetical-modification-of-a-patients-own-immune-cells-t-cell-receptors-using-crispr-cas9-gene-editing-tool-the-engineered-t-cells-are-ver/

 

 

2.1.4 Ethics Issues related to CRISPR Technology

 

 

Hypergraph Plot #14 and Tree Diagram #14

for 2.1.4 based on 6 articles & on 15 keywords

 

gene, crispr, human, editing, cas, genome, technology, cells,

genetic, embryos, genes, dna, cancer, nature, germline

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

 

List of articles included in 2.1.4

 

2.1.4.1   Level of Comfort with Making Changes to the DNA of an Organism

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/08/30/level-of-comfort-with-making-changes-to-the-dna-of-an-organism/

 

2.1.4.2   Opportunities and Ethics of Editing Genomes: A CRISPR-Inspired Conversation, Prof. Jennifer Doudna’s Lecture at Stanford University, JANUARY 24, 2019 – 7:00PM TO 8:30PM, CEMEX AUDITORIUM, GRADUATE SCHOOL OF BUSINESS

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/01/16/opportunities-and-ethics-of-editing-genomes-a-crispr-inspired-conversation-prof-jennifer-doudnas-lecture-at-stanford-university-january-24-2019-700pm-to-830pm-cemex-auditorium-graduate-sc/

 

2.1.4.3   Gene-editing Second International Summit in Hong Kong: George Church, “Let’s be quantitative before we start being accusatory”

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/11/29/gene-editing-summit-in-hong-kong-george-church-lets-be-quantitative-before-we-start-being-accusatory/

 

2.1.4.4   GENE EDITING: Promises and Challenges: HSPH and NBC News Digital, Friday, May 19, 2017  Live webcast: 12:30-1:30pm ET

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/05/15/gene-editing-promises-and-challenges-hsph-and-nbc-news-digital-friday-may-19-2017-live-webcast-1230-130pm-et/

 

2.1.4.5   CRISPR and Human Embryo

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/18/crispr-and-human-embryo/

 

2.1.4.6   Unchecked Spread of Engineered Genes

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/18/unchecked-spread-of-engineered-genes/

 

2.1.5   Other topics related to the advent of CRISPR as a Gene Editing Method

 

Hypergraph Plot #15 and Tree Diagram #15

for 2.1.5 based on 28 articles & on 11 keywords

 

crispr, cells, cas, editing, dna, genome, technology, rna,

genes, human, genetic

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 2.1.5

 

2.1.5.1   A. Richard Newton Distinguished Innovator Lecture Series – Dr. Jennifer Doudna, April 23, 2019, UC, Berkeley

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/05/16/a-richard-newton-distinguished-innovator-lecture-series-dr-jennifer-doudna-april-23-2019-uc-berkeley/

 

2.1.5.2   Top 10 CRISPR Podcasts Every Scientist (& Non-Scientist) by Synthego.com

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/03/09/top-10-crispr-podcasts-every-scientist-non-scientist-by-synthego-com/

 

2.1.5.3   National Academy of Sciences for work in chemical sciences: Jennifer Doudna, University of California, Berkeley

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/02/08/national-academy-of-sciences-for-work-in-chemical-sciences-jennifer-doudna-university-of-california-berkeley/

 

2.1.5.4   CRISPR Based Research Awarded NHGRI Grants, The University of California, Berkeley’s Doudna will receive $2.1 million and The Broad Institute’s Zhang will receive $1.1 million

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/08/25/crispr-based-research-awarded-nhgri-grants-the-university-of-california-berkeleys-doudna-will-receive-2-1-million-and-the-broad-institutes-zhang-will-receive-1-1-million/

 

2.1.5.5   Promising research for a male birth control pill

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2017/03/23/promising-research-for-a-male-birth-control-pill/

 

2.1.5.6   Top 50 Women in CRISPR : Women in CRISPR, Legal Status of Inventions and Declaration of the Heroes in CRISPR

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/01/31/top-50-women-in-crispr-women-in-crispr-legal-status-of-inventions-and-declation-of-the-heroes-in-crispr/

 

2.1.5.7   We Celebrate 5,000 Scientific Articles @pharmaceuticalintelligence.com – 2016 was a GREAT Year – Record Articles on CRISPR !!!!!

Curator and Open Access Journal Editor-in-Chief: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/12/19/we-celebrate-5000-scientific-articles-pharmaceuticalintelligence-com-2016-was-a-great-year/

 

2.1.5.8   LIVE – Day 1, OCTOBER 18 @The 16th annual EmTech MIT – A Place of Inspiration, October 18-20, 2016, Cambridge, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/10/18/live-day-1-october-18-the-16th-annual-emtech-mit-a-place-of-inspiration-october-18-20-2016-cambridge-ma/

 

2.1.5.9   More Awards to Jennifer Doudna: 2016 Warren Alpert Foundation Prize and The 2015 Pfizer Lecture

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/10/09/more-awards-to-jennifer-doudna-2016-warren-alpert-foundation-prize-and-the-2015-pfizer-lecture/

 

2.1.5.10   Federation of European Biochemical Societies FEBS Journal Special Issue on CRISPR/Cas9 Gene Editing by news.wiley.com – State of CRISPR/Cas9 Science on 9/2016

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/10/06/febs-journal-special-issue-on-crispr-by-news-wiley-com/

 

2.1.5.11   Real Time Coverage and eProceedings of Presentations on 9/19-9/21 @CHI’s 14th Discovery On Target, 9/19 – 9/22/2016, Westin Boston Waterfront, Boston

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/09/25/real-time-coverage-and-eproceedings-of-presentations-on-919-922-chis-14th-discovery-on-target-919-9222016-westin-boston-waterfront-boston/

 

2.1.5.12   Genomics Orientations for Personalized Medicine: Request for Book Review Writing on Amazon.com

http://www.amazon.com/dp/B018DHBUO6

 

2.1.5.13   The Roles of Graduate Students and Postdocs in the Emergence of Gene Editing: CRISPR Science and Technology

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/25/the-roles-of-graduate-students-and-postdocs-in-the-emergence-of-gene-editing-crispr-science-and-technology/

 

2.1.5.14   A Conversation with Jennifer Doudna, Interviewer: Jan Witkowski, Executive Director, Banbury Center at Cold Spring Harbor Laboratory

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/17/a-conversation-with-jennifer-doudna-interviewer-jan-witkowski-executive-director-banbury-center-at-cold-spring-harbor-laboratory/

 

2.1.5.15   Women Leaders in Cell and Gene Therapy

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/11/women-leaders-in-cell-and-gene-therapy/

  

2.1.5.16   John Holdren tells Nature about the Highs and Lows of nearly eight years in the White House, Holdren is the longest-serving presidential Science Adviser in US history.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/07/john-holdren-tells-nature-he-is-the-longest-serving-presidential-science-adviser-in-us-history/

 

2.1.5.17   Glassman Lecture “From Bacterial Adaptive Immunity to the Future of Genome Engineering” Jennifer A. Doudna, University of California, Berkeley; Howard Hughes Medical Institute

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/06/glassman-lecture-from-bacterial-adaptive-immunity-to-the-future-of-genome-engineering-jennifer-a-doudna-university-of-california-berkeley-howard-hughes-medical-institute/

 

2.1.5.18   Genome Engineering: The CRISPR-Cas Revolution, August 17 – 20, 2016, Cold Spring Harbor Laboratory

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/05/31/genome-engineering-the-crispr-cas-revolution-august-17-20-2016-cold-spring-harbor-laboratory/

 

2.1.5.19   The 16th annual EmTech MIT – A Place of Inspiration, October 18-20, 2016, Cambridge, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/05/17/the-16th-annual-emtech-mit-a-place-of-inspiration-october-18-20-2016-cambridge-ma/

 

2.1.5.20   CRISPR: Genome Editing and Cancer was ranked 7th on the List of Disruptive Dozen Technologies @2016 World Medical Innovation Forum

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/04/27/crispr-genome-editing-and-cancer-was-ranked-7th-on-the-list-of-disruptive-dozen-technologies-2016-world-medical-innovation-forum/

 

2.1.5.21   Best in Precision Medicine: RNA May Surpass DNA in Precision Medicine

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/03/23/best-in-precision-medicine/

 

2.1.5.22   Jennifer Doudna, Woman of Science Award

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/03/18/jennifer-doudna-woman-of-science-award/

 

2.1.5.23   CRISPR: A Podcast from Nature.com on Gene Editing

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/03/17/crispr-a-podcast-from-nature-com-on-gene-editing/

 

2.1.5.24   Lab Management: About The Doudna Lab, RNA Biology at UC Berkeley, HHMI

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/21/lab-management-about-the-doudna-lab-rna-biology-at-uc-berkeley-hhmi/

 

2.1.5.25   International Summit on Human Gene Editing: A Global Discussion, National Academy of Sciences, WashDC, December 1-3, 2015

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/11/30/international-summit-on-human-gene-editing-a-global-discussion-national-academy-of-sciences-washdc-december-1-3-2015/

 

2.1.5.26   Cambridge Healthtech Institute’s Second Annual New Frontiers in Gene Editing, SF, 3/10-3/11, 2016

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2015/11/16/cambridge-healthtech-institutes-second-annual-new-frontiers-in-gene-editing/

 

2.1.5.27   CRISPR/Cas-mediated Genome Engineering

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/09/08/crisprcas-mediated-genome-engineering/

 

2.1.5.28   Advances in Gene Editing and Gene Silencing | September 20-21, 2016 | Boston, MA

Author and Curator: Stephen J Williams, PhD

https://pharmaceuticalintelligence.com/2016/07/28/advances-in-gene-editing-and-gene-silencing-september-20-21-2016-boston-ma/

 

2.2 Technologies and Methodologies

 

Hypergraph Plot #16 and Tree Diagram #16

for 2.2 based on 27 articles & on 13 keywords

 

cas, crispr, dna, protein, expression, stem, rna, target,

genome, editing, genes, cancer, human

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 2.2

 

2.2.1   Alter the Code of Life – Technologies for Gene Editing from MammothBiosciences, San Francisco, CA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/05/16/alter-the-code-of-life-technologies-for-gene-editing-from-mammothbiosciences-san-francisco-ca/

 

2.2.2   CRISPR on TED Ideas worth spreading – Ellen Jorgensen

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/02/08/crispr-on-ted-ideas-worth-spreading-ellen-jorgensen/

 

2.2.3   CRISPR snips a strand of DNA – Visualization of the Process

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/02/04/crispr-snips-a-strand-of-dna-visualization-of-the-process/

 

2.2.4   Pancreatic Cancer Modeling using Retrograde Viral Vector Delivery and IN-Vivo CRISPR/Cas9-mediated Somatic Genome Editing

Curators: Larry H. Benstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/06/10/pancreatic-cancer-modeling-using-retrograde-viral-vector-delivery-and-in-vivo-crisprcas9-mediated-somatic-genome-editing/

 

2.2.5   Bacterial immune system may be utilized as a tool harboring an impressive recording capacity

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/06/10/bacterial-immune-system-may-be-utilized-as-a-tool-harboring-an-impressive-recording-capacity/

 

2.2.6   CHI’s Inaugural Oligonucleotide Therapeutics & Delivery | April 4-5, 2016 | Hyatt Regency | Cambridge, Massachusetts

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/03/15/chis-inaugural-oligonucleotide-therapeutics-delivery-april-4-5-2016-hyatt-regency-cambridge-massachusetts/

 

2.2.7   Innovative Genomics Initiative (IGI)  2016 CRISPR WORKSHOP: PRACTICAL ASPECTS OF PRECISION BIOLOGY, UC, Berkeley, July 11-15, 2016

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/02/17/innovative-genomics-initiative-igi-2016-crispr-workshop-practical-aspects-of-precision-biology-uc-berkeley-july-11-15-2016/

 

2.2.8   RNA-Based Drugs Turn CRISPR/Cas9 On and Off

Reporter: Stephen J. Williams

https://pharmaceuticalintelligence.com/2016/02/17/rna-based-drugs-turn-crisprcas9-on-and-off/

 

2.2.9   Reengineering Therapeutics

Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/02/06/reengineering-therapeutics/

 

2.2.10   Deciphering the Epigenome

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/28/deciphering-the-epigenome/

 

2.2.11   Gene Editing for Exon 51: Why CRISPR Snipping might be better than Exon Skipping for DMD

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/23/gene-editing-for-exon-51-why-crispr-snipping-might-be-better-than-exon-skipping-for-dmd/

 

2.2.12   Genome Engineering: Genome Editing with CRISPR-Cas9

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/19/genome-engineering-genome-editing-with-crispr-cas9/

 

2.2.13   Enhanced Cas9 for more precise editing

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/12/11/enhanced-cas9-for-more-precise-editing/

 

2.2.14   Genetically Engineered Algae

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/15/genetically-engineered-algae/

 

2.2.15   Cas9 Proofreads

Curator: Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/13/cas9-proofreads/

 

2.2.16   RNAi, CRISPR and Gene Expression

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/02/rnai-crispr-and-gene-expression/

 

2.2.17   Obesity Variant Circuitry

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/10/31/obesity-variant-circuitry/

 

2.2.18   CRISPR-Cas9 and Regenerative Medicine

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/10/31/crispr-cas9-crispr-cas9-and-regenerative-medicine/

 

2.2.19   Gene Editing by Creation of a Complement without Transcription Error

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/10/30/gene-editing-by-creation-of-a-complement-without-transcription-error/

 

2.2.20   Principles of Gene Editing

Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/10/30/principles-of-gene-editing/

 

2.2.21   Top 10 Medical Innovations for 2016 by Cleveland Clinic

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/10/28/top-10-medical-innovations-for-2016-by-cleveland-clinic/

 

2.2.22   NIH to Award Up to $12M to Fund DNA, RNA Sequencing Research: single-cell genomics,  sample preparation, transcriptomics and epigenomics, and  genome-wide functional analysis.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/10/27/nih-to-award-up-to-12m-to-fund-dna-rna-sequencing-research-single-cell-genomics-sample-preparation-transcriptomics-and-epigenomics-and-genome-wide-functional-analysis/

 

2.2.23   CRISPR/Cas9 genome editing tool for Staphylococcus aureus Cas9 complex (SaCas9) @ MIT’s Broad Institute

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/08/30/crisprcas9-genome-editing-tool-for-staphylococcus-aureus-cas9-complex-sacas9-mits-broad-institute/

 

2.2.24   RNAi, CRISPR, and Gene Editing: Discussions on How To’s and Best Practices @14th Annual World Preclinical Congress  June 10-12, 2015 | Westin Boston Waterfront | Boston, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/05/12/rnai-crispr-and-gene-editing-discussions-on-how-tos-and-best-practices-14th-annual-world-preclinical-congress-june-10-12-2015-westin-boston-waterfront-boston-ma/

 

2.2.25   CRISPR/Cas9: Contributions on Endoribonuclease Structure and Function, Role in Immunity and Applications in Genome Engineering

Writer and Curator:Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/03/27/crisprcas9/

 

2.2.26   GUIDE-seq: First genome-wide method of detecting off-target DNA breaks induced by CRISPR-Cas nucleases

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2014/12/22/guide-seq-first-genome-wide-method-of-detecting-off-target-dna-breaks-induced-by-crispr-cas-nucleases/

 

2.2.27   2nd Annual Translational Gene Editing: Exploiting CRISPR/Cas9 for Building Tools for Drug Discovery & Development: June 16, 2016 @Boston, MA

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2016/03/30/2nd-annual-translational-gene-editing-exploiting-crisprcas9-for-building-tools-for-drug-discovery-development-june-16-2016boston-ma/

 

2.3  CRISPR – The Clinical Aspects

 

Hypergraph Plot #17 and Tree Diagram #17

for 2.3 based on 9 articles & on 15 keywords

 

crispr, cas, editing, cells, disease, genome, dna, human,

genetic, target, therapy, ttr, protein, genes, amyloid

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 
TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 2.3

 


2.3.1   Sickle Cell and Beta Thalassemia chosen for first human trial of the gene editing technology, CRISPR by sponsoring companies CRISPR Therapeutics and Vertex Pharmaceuticals, trial at a single site in Germany

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/09/04/sickle-cell-and-beta-thalassemia-chosen-for-first-human-trial-of-the-gene-editing-technology-crispr-by-sponsoring-companies-crispr-therapeutics-and-vertex-pharmaceuticals-trial-at-a-single-site/

 

2.3.2   Updated: First-in-Man: CRISPR, the Genome Editing Technology is Nearing Human Trials: Human T cells will soon be Modified using the CRISPR Technique in a Clinical Trial to attack Cancer Cells

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/06/22/crispr-the-genome-editing-technology-is-nearing-human-trials-human-t-cells-will-soon-be-modified-using-the-crispr-technique-in-a-clinical-trial-to-attack-cancer-cells/

 

2.3.3   The Promise of Gene Editing for Slowing Progression of Disease: Translational Application toward Cure of Disease

Reporters: Gerard Loiseau, ESQ and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/06/the-promise-of-gene-editing-for-slowing-progression-of-disease-translational-application-toward-cure-of-disease/

 

2.3.4   Translational Gene Editing – June 16-17, 2016 in Boston, MA by CHI, Westin Boston Waterfront, Boston, MA

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/12/15/translational-gene-editing-june-16-17-2016-in-boston-ma-by-chi-westin-boston-waterfront-boston-ma/

 

2.3.5   FDA Cellular & Gene Therapy Guidances: Implications for CRSPR/Cas9 Trials

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2015/11/10/fda-cellular-gene-therapy-guidances-implications-for-crsprcas9-trials/

 

2.3.6   CRISPR Gene Editing Trial

Curator: Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/10/crispr-gene-editing-trial/

 

2.3.7   UNESCO Calls for More Regulations on Genome Editing, DTC Genetic Testing

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/10/08/unesco-calls-for-more-regulations-on-genome-editing-dtc-genetic-testing-oct-06-2015-a-genomeweb-staff-reporter-new-york-genomeweb-the-united-nations-educational-scientific-and-cultur/

 

2.3.8   CRISPR/Cas9, Familial Amyloid Polyneuropathy (FAP) and Neurodegenerative Disease

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/17/crisprcas9-fap-and-neurodegenerative-disease/

 

2.3.9   CRISPR cuts turn gels into biological watchdogs

Reporter: Irina Robu, PhD

https://pharmaceuticalintelligence.com/2019/08/30/crispr-cuts-turn-gels-into-biological-watchdogs/

2.4 CRISPR – Business and Legal

 

Hypergraph Plot #18 and Tree Diagram #18

for 2.4 based on 20 articles & on 10 keywords

 

crispr, cas, editing, patents, gene, therapeutics, cells,

interference, genomics, biotech

 

HYPERGRAPH DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 2.4

 

2.4.1   CRISPR – The Business and Legal Aspects of IP Development

Patent on Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription was awarded to UC, Berkeley on October 30, 2018

  • site-specific modification of a target DNA and/or a polypeptide associated with the target DNA, a DNA-targeting RNA
  • genetically modified cells that produce Cas9 and Cas9 transgenic non-human multicellular organisms.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/11/01/patent-on-methods-and-compositions-for-rna-directed-target-dna-modification-and-for-rna-directed-modulation-of-transcription-was-awarded-to-uc-berkeley-on-october-30-2018/

 

2.4.2   Will the Supreme Court accept a UC Berkeley Appeal of the Sep. 10th, US Court of Appeals for the Federal Circuit decision to uphold the patent filed by the Broad Institute on CRISPR/Cas9 gene editing?

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/09/14/will-the-supreme-court-accept-a-uc-berkeley-appeal-of-the-sep-10th-us-court-of-appeals-for-the-federal-circuit-decision-to-uphold-the-patent-filed-by-the-broad-institute-on-crispr-cas9-gen/

 

2.4.3   On June 12, 2018 – Berkeley was granted a patent on using CRISPR/Cas9 to edit single-stranded RNA. On June 19, 2018 – Berkeley was granted a second patent, covering the use of CRISPR-Cas9 gene editing with formats that will be particularly useful in developing human therapeutics and improvements in food security.

Reporter and Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/06/21/on-june-12-2018-berkeley-was-granted-a-patent-on-using-crispr-cas9-to-edit-single-stranded-rna-on-june-19-2018-berkeley-was-granted-a-second-patent-covering-the-use-of-crispr-ca/

 

2.4.4   Developments in CRISPR Patent Dispute: EPO Revokes Broad’s CRISPR Patent

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/01/20/developments-in-crispr-patent-dispute-epo-revokes-broads-crispr-patent/

 

2.4.5   Appellate Brief Seeking Reversal of U.S. Patent Board Decision on CRISPR/Cas9 Gene Editing

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/08/01/appellate-brief-seeking-reversal-of-u-s-patent-board-decision-on-crisprcas9-gene-editing/

 

2.4.6   Doudna and Charpentier and their teams to receive wide-ranging patents in many countries:  European Patent Office (EPO) and UK Intellectual Property Office – broad patent for CRISPR-Cas9 gene-editing technology to the University of California and the University of Vienna

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/04/28/doudna-and-charpentier-and-their-teams-to-receive-wide-ranging-patents-in-many-countries-european-patent-office-epo-and-uk-intellectual-property-office-broad-patent-for-crispr-cas9-gene-editing/

 

2.4.7   UPDATED – Gene Editing Consortium of Biotech Companies: CRISPR Therapeutics $CRSP, Intellia Therapeutics $NTLA, Caribou Biosciences, ERS Genomics, UC, Berkeley (Doudna’s IP) and University of Vienna (Charpentier’s IP), is appealing the decision ruled that there was no interference between the two sides, to the U.S. Court of Appeals for the Federal Circuit, targeting patents from The Broad Institute.

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/04/13/gene-editing-consortium-of-biotech-companies-crispr-therapeutics-crsp-intellia-therapeutics-ntla-caribou-biosciences-and-ers-genomics-uc-berkeley-doudnas-ip-and-university-of-vienna-charpe/

 

2.4.8   CRISPR Patent Battle Determined on 2/15/2017 – USPTO issues a verdict in legal tussle over rights to genome-editing technology

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/02/16/crispr-patent-battle-determined-on-2152017-uspto-issues-a-verdict-in-legal-tussle-over-rights-to-genome-editing-technology/

 

2.4.9   Dr. Doudna: RNA synthesis capabilities of Synthego’s team represent a significant leap forward for Synthetic Biology

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/01/04/dr-doudna-rna-synthesis-capabilities-of-synthegos-team-represent-a-significant-leap-forward-for-synthetic-biology/

 

2.4.10   Dr. Jennifer Doudna (UC Berkeley): PMWC 2017 Luminary Award, January 22, 2017 @PMWC 2017, January 23-25, Silicon Valley

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/12/20/dr-jennifer-doudna-uc-berkeley-pmwc-2017-luminary-award-january-22-2017-pmwc-2017-january-23-25-silicon-valley/

 

2.4.11   CRISPR Therapeutics raises a $56M IPO, but patent battles, potential stock drops loom

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/10/19/crispr-therapeutics-raises-a-56m-ipo-but-patent-battles-potential-stock-drops-loom/

 

2.4.12   Licensing Agreements for CRISPR/Cas9 Genome Editing Technology Patent

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/08/24/licensing-agreements-for-crisprcas9-genome-editing-technology-patent/

 

2.4.13   Licensing deal with Regeneron to accelerate CRISPR biotech Intellia (Jennifer Doudna’s Start Up) for an IPO

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/04/12/licensing-deal-with-regeneron-to-accelerate-crispr-biotech-intellia-jennifer-doudnas-start-up-for-an-ipo/

 

2.4.14   Nine Parties had come forward: Opposition Procedure to the Broad Institute’s first European CRISPR–Cas9 Patent

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/03/17/nine-parties-had-come-forward-opposition-procedure-to-the-broad-institutes-first-european-crispr-cas9-patent/

 

2.4.15   Use of CRISPR/CAS9 to Edit Genome of Pigs: Recominetics announces $10M Funding Round

Reporter: Stephen J. Williams

https://pharmaceuticalintelligence.com/2016/02/12/use-of-crisprcas9-to-edit-genome-of-pigs-recominetics-announces-10m-funding-round/

 

2.4.16   UPDATED – Status “Interference — Initial memorandum” – CRISPR/Cas9 – The Biotech Patent Fight of the Century: UC, Berkeley and Broad Institute @MIT

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/01/06/status-interference-initial-memorandum-crisprcas9-the-biotech-patent-fight-of-the-century/

 

2.4.17   Editas, CEO predicts 2017 to be the Year of Human Gene Editing

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/12/08/editas-ceo-predicts-2017-to-be-the-year-of-human-gene-editing/

 

2.4.18   Anatomy of a $105M Deal for Joint R&D in Genomics: CRISPR Therapeutics & Vertex Pharmaceuticals

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/10/26/anatomy-of-a-105m-deal-for-joint-rd-in-genomics-crispr-therapeutics-vertex-pharmaceuticals/

 

2.4.19   CRISPR companies calling for article retraction from Nature Methods – If the same or similar sequence of letters appears elsewhere in the genome, that can result in an unintentional or off-target edit – Concerns of Harm caused by Gene Editing using CRISPR-Cas9

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/11/12/crispr-companies-calling-for-article-retraction-from-nature-methods-if-the-same-or-similar-sequence-of-letters-appears-elsewhere-in-the-genome-that-can-result-in-an-unintentional-or-off-target-edit/

 

2.4.20   Merck KGaA-owned Sigma-Aldrich has petitioned the US Patent and Trademark Office (USPTO) to open an interference proceeding between its own pending CRISPR-Cas9 patents and patents awarded to the University of California, Berkeley (UC Berkeley).

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/23/on-july-19-2019-merck-kgaa-owned-sigma-aldrich-has-petitioned-the-us-patent-and-trademark-office-uspto-to-open-an-interference-proceeding-between-its-own-pending-crispr-cas9-patents-and/

 

Text Analysis with NLP of the Original

Genomics Volume 2, Part 3:

Artificial Intelligence in Medicine

3.1 The Science

 

Hypergraph Plot #19 and Tree Diagram #19

for 3.1 based on 8 articles & on 9 keywords

 

ai, data, health, medicine, clinical, healthcare, patient,

radiology, innovation

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 3.1

 

3.1.1   World Medical Innovation Forum, Partners Innovations, ARTIFICIAL INTELLIGENCE | APRIL 8–10, 2019 | Westin, BOSTON

Reporter: Aviva Lev-Ari, PhD, RN

https://worldmedicalinnovation.org/agenda/

https://pharmaceuticalintelligence.com/2019/02/14/world-medical-innovation-forum-partners-innovations-artificial-intelligence-april-8-10-2019-westin-boston/

 

 

3.1.2   LIVE Day Three – World Medical Innovation Forum ARTIFICIAL INTELLIGENCE, Boston, MA USA, Monday, April 10, 2019

Real Time Coverage: Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/04/10/live-day-three-world-medical-innovation-forum-artificial-intelligence-boston-ma-usa-monday-april-10-2019/

 

3.1.3   LIVE Day Two – World Medical Innovation Forum ARTIFICIAL INTELLIGENCE, Boston, MA USA, Monday, April 9, 2019

Real Time Coverage: Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/04/09/live-day-two-world-medical-innovation-forum-artificial-intelligence-boston-ma-usa-monday-april-9-2019/

 

3.1.4   LIVE Day One – World Medical Innovation Forum ARTIFICIAL INTELLIGENCE, Boston, MA USA, Monday, April 8, 2019

Real Time Coverage: Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/04/08/live-day-one-world-medical-innovation-forum-artificial-intelligence-westin-copley-place-boston-ma-usa-monday-april-8-2019/

 

3.1.5   2018 Annual World Medical Innovation Forum Artificial Intelligence April 23–25, 2018 Boston, Massachusetts  | Westin Copley Place https://worldmedicalinnovation.org/

Real Time Coverage: Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/01/18/2018-annual-world-medical-innovation-forum-artificial-intelligence-april-23-25-2018-boston-massachusetts-westin-copley-place/

 

3.1.6   Synopsis Days 1,2,3: 2018 Annual World Medical Innovation Forum Artificial Intelligence April 23–25, 2018 Boston, Massachusetts  | Westin Copley Place

Real Time Coverage: Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/04/26/synopsis-days-123-2018-annual-world-medical-innovation-forum-artificial-intelligence-april-23-25-2018-boston-massachusetts-westin-copley-place/

 

3.1.7   Interview with Systems Immunology Expert Prof. Shai Shen-Orr

Reporter: Aviva Lev-Ari, PhD, RN

Interview with Systems Immunology Expert Prof. Shai Shen-Orr

 

3.1.8   Unique immune-focused AI model creates largest library of inter-cellular communications at CytoReason. Used  to predict 335 novel cell-cytokine interactions, new clues for drug development.

Reporter: Aviva Lev-Ari, PhD, RN

  • CytoReason features in hashtag #DeepKnowledgeVentures‘s detailed Report on AIin hashtag #drugdevelopment report
  • https://lnkd.in/dKV2BB6

https://www.eurekalert.org/pub_releases/2018-06/c-uia061818.php

 

3.2 Technologies and Methodologies

 

Hypergraph Plot #20 and Tree Diagram #20

for 3.2 based on 9 articles & on 11 keywords

 

cells, cancer, gene, schizophrenia, protein, brain, frontal,

imaging, patients, disease, dna

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 3.2

 

3.2.1   R&D for Artificial Intelligence Tools & Applications: Google’s Research Efforts in 2018

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/01/16/rd-for-artificial-intelligence-tools-applications-googles-research-efforts-in-2018/

 

3.2.2   Can Blockchain Technology and Artificial Intelligence Cure What Ails Biomedical Research and Healthcare

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2018/12/10/can-blockchain-technology-and-artificial-intelligence-cure-what-ails-biomedical-research-and-healthcare/

 

3.2.3   N3xt generation carbon nanotubes

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/12/14/n3xt-generation-carbon-nanotubes/

 

3.2.4   Mindful Discoveries

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/28/mindful-discoveries/

 

3.2.5   Novel Discoveries in Molecular Biology and Biomedical Science

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/30/novel-discoveries-in-molecular-biology-and-biomedical-science/

 

3.2.6   Imaging of Cancer Cells

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/04/20/imaging-of-cancer-cells/

 

3.2.7   Retrospect on HistoScanning: an AI routinely used in diagnostic imaging for over a decade

Author and Curator: Dror Nir, PhD

https://pharmaceuticalintelligence.com/2019/06/22/retrospect-on-histoscanning-an-ai-routinely-used-in-diagnostic-imaging-for-over-a-decade/

 

3.2.8    Prediction of Cardiovascular Risk by Machine Learning (ML) Algorithm: Best performing algorithm by predictive capacity had area under the ROC curve (AUC) scores: 1st, quadratic discriminant analysis; 2nd, NaiveBayes and 3rd, neural networks, far exceeding the conventional risk-scaling methods in Clinical Use

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/04/prediction-of-cardiovascular-risk-by-machine-learning-ml-algorithm-best-performing-algorithm-by-predictive-capacity-had-area-under-the-roc-curve-auc-scores-1st-quadratic-discriminant-analysis/

 

3.2.9   An Intelligent DNA Nanorobot to Fight Cancer by Targeting HER2 Expression

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/07/24/an-intelligent-dna-nanorobot-to-fight-cancer-by-targeting-her2-expression/

 

3.3   Clinical Aspects

 

Hypergraph Plot #21 and Tree Diagram #21

for 3.3 based on 23 articles & on 12 keywords

 

data, cancer, patients, ai, clinical, exon, gene, splicing, health,

cells, rna, imaging

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 3.3

 

3.3.1   9 AI-based initiatives catalyzing immunotherapy in 2018

By Tanima Bose

https://www.prescouter.com/2018/07/9-ai-based-initiatives-catalyzing-immunotherapy-in-2018/

 

3.3.2   mRNA Data Survival Analysis

Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/06/18/mrna-data-survival-analysis/

 

3.3.3   Medcity Converge 2018 Philadelphia: Live Coverage @pharma_BI

Reporter: Stephen J. Williams

https://pharmaceuticalintelligence.com/2018/07/11/medcity-converge-2018-philadelphia-live-coverage-pharma_bi/

 

3.3.4   Live Coverage: MedCity Converge 2018 Philadelphia: AI in Cancer and Keynote Address

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2018/07/11/live-coverage-medcity-converge-2018-philadelphia-ai-in-cancer-and-keynote-address/

 

3.3.5   VIDEOS: Artificial Intelligence Applications for Cardiology

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/03/11/videos-artificial-intelligence-applications-for-cardiology/

 

3.3.6   Artificial Intelligence in Health Care and in Medicine: Diagnosis & Therapeutics

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/01/21/artificial-intelligence-in-health-care-and-in-medicine-diagnosis-therapeutics/

 

3.3.7   Digital Therapeutics: A Threat or Opportunity to Pharmaceuticals

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/03/18/digital-therapeutics-a-threat-or-opportunity-to-pharmaceuticals/

 

3.3.8   The 3rd STATONC Annual Symposium, April 25-27, 2019, Hilton Hartford, CT, 315 Trumbull St., Hartford, CT 06103

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/02/26/the-3rd-stat4onc-annual-symposium-april-25-27-2019-hilton-hartford-connecticut/

 

3.3.9   2019 Biotechnology Sector and Artificial Intelligence in Healthcare

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/05/10/2019-biotechnology-sector-and-artificial-intelligence-in-healthcare/

 

3.3.10   Artificial intelligence can be a useful tool to predict Alzheimer

Reporter: Irina Robu, PhD

https://pharmaceuticalintelligence.com/2019/01/26/artificial-intelligence-can-be-a-useful-tool-to-predict-alzheimer/

 

3.3.11   Unlocking the Microbiome

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/02/07/unlocking-the-microbiome/

 

3.3.12   Biomarker Development

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/11/16/biomarker-development/

 

3.3.13   AI System Used to Detect Lung Cancer

Reporter: Irina Robu, PhD

https://pharmaceuticalintelligence.com/2019/06/28/ai-system-used-to-detect-lung-cancer/

 

3.3.14   AI App for People with Digestive Disorders

Reporter: Irina Robu, PhD

https://pharmaceuticalintelligence.com/2019/06/24/ai-app-for-people-with-digestive-disorders/

 

3.3.15   Sepsis Detection using an Algorithm More Efficient than Standard Methods

Reporter: Irina Robu, PhD

https://pharmaceuticalintelligence.com/2019/06/25/sepsis-detection-using-an-algorithm-more-efficient-than-standard-methods/

 

3.3.16   How Might Sleep Apnea Lead to Serious Health Concerns like Cardiac and Cancer?

Author: Larry H Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2013/03/20/how-might-sleep-apnea-lead-to-serious-health-concerns-like-cardiac-and-cancers/

 

3.3.17   An Intelligent DNA Nanorobot to Fight Cancer by Targeting HER2 Expression

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/07/24/an-intelligent-dna-nanorobot-to-fight-cancer-by-targeting-her2-expression/

 

3.3.18   Artificial Intelligence and Cardiovascular Disease

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/07/26/artificial-intelligence-and-cardiovascular-disease/

 

3.3.19   Using A.I. to Detect Lung Cancer gets an A!

Reporter: Irina Robu, PhD

https://pharmaceuticalintelligence.com/2019/08/04/using-a-i-to-detect-lung-cancer-gets-an-a/

 

3.3.20   Complex rearrangements and oncogene amplification revealed by long-read DNA and RNA sequencing of a breast cancer cell line

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2019/08/14/complex-rearrangements-and-oncogene-amplification-revealed-by-long-read-dna-and-rna-sequencing-of-a-breast-cancer-cell-line/

 

3.3.21   Multiple Barriers Identified Which May Hamper Use of Artificial Intelligence in the Clinical Setting

Reporter: Stephen J. Williams, PhD.

https://pharmaceuticalintelligence.com/2019/07/21/multiple-barriers-identified-which-may-hamper-use-of-artificial-intelligence-in-the-clinical-setting/

 

3.3.22   Deep Learning–Assisted Diagnosis of Cerebral Aneurysms

Author and Curator: Dror Nir, PhD

https://pharmaceuticalintelligence.com/2019/06/09/deep-learning-assisted-diagnosis-of-cerebral-aneurysms/

 

3.3.23   Artificial Intelligence Innovations in Cardiac Imaging

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/12/17/artificial-intelligence-innovations-in-cardiac-imaging/

 

3.4 Business and Legal

 

Hypergraph Plot #22 and Tree Diagram #22

for 3.4 based on 16 articles & on 8 keywords

 

ai ,data, healthcare, patients, medical, digital,

clinical, access

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 3.4

 

3.4.1   McKinsey Top Ten Articles on Artificial Intelligence: 2018’s most popular articles – An executive’s guide to AI

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/01/21/mckinsey-top-ten-articles-on-artificial-intelligence-2018s-most-popular-articles-an-executives-guide-to-ai/

 

3.4.2   HOTTEST Artificial Intelligence Hub: Israel’s High Tech Industry – Why?

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/09/30/hottest-artificial-intelligence-hub-israels-high-tech-industry-why/

 

3.4.3   The Regulatory challenge in adopting AI

Author and Curator: Dror Nir, PhD

https://pharmaceuticalintelligence.com/2019/04/07/the-regulatory-challenge-in-adopting-ai/

 

3.4.4   HealthCare focused AI Startups from the 100 Companies Leading the Way in A.I. Globally

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/01/18/healthcare-focused-ai-startups-from-the-100-companies-leading-the-way-in-a-i-globally/

 

3.4.5   IBM’s Watson Health division – How will the Future look like?

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/04/24/ibms-watson-health-division-how-will-the-future-look-like/

 

3.4.6   HUBweek 2018, October 8-14, 2018, Greater Boston – “We The Future” – coming together, of breaking down barriers, of convening across disciplinary lines to shape our future

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/10/08/hubweek-2018-october-8-14-2018-greater-boston-we-the-future-coming-together-of-breaking-down-barriers-of-convening-across-disciplinary-lines-to-shape-our-future/

 

3.4.7   Role of Informatics in Precision Medicine: Notes from Boston Healthcare Webinar: Can It Drive the Next Cost Efficiencies in Oncology Care?

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/01/03/role-of-informatics-in-precision-medicine-can-it-drive-the-next-cost-efficiencies-in-oncology-care/

 

3.4.8   Healthcare conglomeration to access Big Data and lower costs

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/13/healthcare-conglomeration-to-access-big-data-and-lower-costs/

 

3.4.9   Linguamatics announces the official launch of its AI self-service text-mining solution for researchers.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/05/10/linguamatics-announces-the-official-launch-of-its-ai-self-service-text-mining-solution-for-researchers/

 

3.4.10   Future of Big Data for Societal Transformation

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2015/12/14/future-of-big-data-for-societal-transformation/

 

3.4.11   Deloitte Analysis 2019 Global Life Sciences Outlook

https://www2.deloitte.com/global/en/pages/life-sciences-and-healthcare/articles/global-life-sciences-sector-outlook.html

https://www.cioapplications.com/news/making-a-breakthrough-in-drug-discovery-with-ai-nid-3114.html

https://healthcare.cioapplications.com/cioviewpoint/leveraging-technologies-to-better-position-the-business-nid-1060.html

 

3.4.12   OpenAI: $1 Billion to Create Artificial Intelligence Without Profit Motive by Who is Who in the Silicon Valley

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/12/26/openai-1-billion-to-create-artificial-intelligence-without-profit-motive-by-who-is-who-in-the-silicon-valley/

 

3.4.13   The Health Care Benefits of Combining Wearables and AI

Reporter: Gail S. Thornton, M.A.

https://pharmaceuticalintelligence.com/2019/07/02/the-health-care-benefits-of-combining-wearables-and-ai/

 

3.4.14   These twelve artificial intelligence innovations are expected to start impacting clinical care by the end of the decade.

Reporter: Gail S. Thornton, M.A.

https://pharmaceuticalintelligence.com/2019/07/02/top-12-artificial-intelligence-innovations-disrupting-healthcare-by-2020/

 

3.4.15   Forbes Opinion: 13 Industries Soon To Be Revolutionized By Artificial Intelligence

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/07/31/forbes-opinion-13-industries-soon-to-be-revolutionized-by-artificial-intelligence/

 

3.4.16   AI Acquisitions by Big Tech Firms Are Happening at a Blistering Pace: 2019 Recent Data by CBI Insights

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/12/11/ai-acquisitions-by-big-tech-firms-are-happening-at-a-blistering-pace-2019-recent-data-by-cbiinsights/

 

3.5 Machine Learning (ML) Algorithms harnessed for Medical Diagnosis: Pattern Recognition & Prediction of Disease Onset

 

Hypergraph Plot #23 and Tree Diagram #23

for 3.5 based on 9 articles & on 12 keywords

 

cancer, risk, brain, breast, mri, data, molecular, density,

women, image, aging, tissue

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 3.5

 

3.5.1 Cases in Pathology

 

3.5.1.1   Deep Learning extracts Histopathological Patterns and accurately discriminates 28 Cancer and 14 Normal Tissue Types: Pan-cancer Computational Histopathology Analysis

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/10/28/deep-learning-extracts-histopathological-patterns-and-accurately-discriminates-28-cancer-and-14-normal-tissue-types-pan-cancer-computational-histopathology-analysis/

 

3.5.2 Cases in Radiology

 

3.5.2.1   Cardiac MRI Imaging Breakthrough: The First AI-assisted Cardiac MRI Scan Solution, HeartVista Receives FDA 510(k) Clearance for One Click™ Cardiac MRI Package

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/10/29/cardiac-mri-imaging-breakthrough-the-first-ai-assisted-cardiac-mri-scan-solution-heartvista-receives-fda-510k-clearance-for-one-click-cardiac-mri-package/

 

3.5.2.2   Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

Reporter: Dror Nir, PhD

https://pharmaceuticalintelligence.com/2019/08/01/disentangling-molecular-alterations-from-water-content-changes-in-the-aging-human-brain-using-quantitative-mri/

 

3.5.2.3   Showcase: How Deep Learning could help radiologists spend their time more efficiently

Reporter and Curator: Dror Nir, PhD

https://pharmaceuticalintelligence.com/2019/08/22/showcase-how-deep-learning-could-help-radiologists-spend-their-time-more-efficiently/

 

3.5.2.4   CancerBase.org – The Global HUB for Diagnoses, Genomes, Pathology Images: A Real-time Diagnosis and Therapy Mapping Service for Cancer Patients – Anonymized Medical Records accessible to anyone on Earth

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/28/cancerbase-org-the-global-hub-for-diagnoses-genomes-pathology-images-a-real-time-diagnosis-and-therapy-mapping-service-for-cancer-patients-anonymized-medical-records-accessible-to/

 

3.5.2.5   Applying AI to Improve Interpretation of Medical Imaging

Author and Curator: Dror Nir, PhD

https://pharmaceuticalintelligence.com/2019/05/28/applying-ai-to-improve-interpretation-of-medical-imaging/

 

3.5.2.6   Imaging: seeing or imagining? (Part 2)

Author and Curator: Dror Nir, PhD

https://pharmaceuticalintelligence.com/2019/04/07/imaging-seeing-or-imagining-part-2-2/

 

3.5.3 Cases in Prediction Cancer Onset

 

3.5.3.1  A Deep Learning Mammography-based Model for Improved Breast Cancer Risk Prediction

Adam Yala
Constance Lehman
Tal Schuster
Tally Portnoi

Regina Barzilay

Author Affiliations

Published Online: May 7 2019 RadiologyVol. 292, No. 1 https://doi.org/10.1148/radiol.2019182716

 

3.5.3.2   Comparison of a Deep Learning Risk Score and Standard Mammographic Density Score for Breast Cancer Risk Prediction

Karin Dembrower , Yue Liu, Hossein Azizpour, Martin Eklund, Kevin Smith, Peter Lindholm, Fredrik Strand

Author Affiliations

Published Online: Dec 17 2019 https://doi.org/10.1148/radiol.2019190872

See editorial by Manisha Bahl

 

 

Text Analysis with NLP of the Original

Genomics Volume 2, Part 4:

Single Cell Genomics

4.1 The Science

 

Hypergraph Plot #24 and Tree Diagram #24

for 4.1 based on 9 articles & on 12 keywords

 

cells, human, atlas, genomics, cellular, cancer,

sequencing, disease, map, immune, biology, body

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 4.1

 

4.1.1   Single-cell biology

Special | 05 July 2017

https://www.nature.com/collections/gbljnzchgg

 

4.1.2   The race to map the human body — one cell at a time, A host of detailed cell atlases could revolutionize understanding of cancer and other diseases

  • by Heidi Ledford  20 February 2017

https://www.nature.com/news/the-race-to-map-the-human-body-one-cell-at-a-time-1.21508

 

4.1.3   Single-cell Genomics: Directions in Computational and Systems Biology – Contributions of Prof. Aviv Regev @Broad Institute of MIT and Harvard, Cochair, the Human Cell Atlas Organizing Committee with Sarah Teichmann of the Wellcome Trust Sanger Institute

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/09/03/single-cell-genomics-directions-in-computational-and-systems-biology-contributions-of-ms-aviv-regev-phd-broad-institute-of-mit-and-harvard-cochair-the-human-cell-atlas-organizing-committee-wit/

 

4.1.4   Cellular Genetics

https://www.sanger.ac.uk/science/programmes/cellular-genetics

 

4.1.5   Cellular Genomics

https://www.garvan.org.au/research/cellular-genomics

 

4.1.6   SINGLE CELL GENOMICS 2019 – sometimes the sum of the parts is greater than the whole, September 24-26, 2019, Djurönäset, Stockholm, Sweden http://www.weizmann.ac.il/conferences/SCG2019/single-cell-genomics-2019

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/05/29/single-cell-genomics-2019-september-24-26-2019-djuronaset-stockholm-sweden/

 

4.1.7   Norwich Single-Cell Symposium 2019, Earlham Institute, single-cell genomics technologies and their application in microbial, plant, animal and human health and disease, October 16-17, 2019, 10AM-5PM

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/06/04/norwich-single-cell-symposium-2019-earlham-institute-single-cell-genomics-technologies-and-their-application-in-microbial-plant-animal-and-human-health-and-disease-october-16-17-2019-10am-5pm/

 

4.1.8   Newly Found Functions of B Cell

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/05/23/newly-found-functions-of-b-cell/

 

4.1.9 RESEARCH HIGHLIGHTS: HUMAN CELL ATLAS

https://www.broadinstitute.org/research-highlights-human-cell-atlas

 

4.2 Technologies and Methodologies

Hypergraph Plot #25 and Tree Diagram #25

for 4.2 based on 6 articles & on 12 keywords

 

cells, ai, sequencing, molecular, expression, fluorescence,

protein, rna, streptavidin, population, surface, magnetic

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 4.2

 

4.2.1   How to build a human cell atlas – Aviv Regev is a maven of hard-core biological analyses. Now she is part of an effort to map every cell in the human body.

Anna Nowogrodzki, 05 July 2017, Article tools

https://www.nature.com/news/how-to-build-a-human-cell-atlas-1.22239

 

4.2.2   Featuring Computational and Systems Biology Program at Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute (SKI), The Dana Pe’er Lab

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/06/16/featuring-computational-and-systems-biology-program-at-memorial-sloan-kettering-cancer-center-sloan-kettering-institute-ski-the-dana-peer-lab/

 

4.2.3   Genomic Diagnostics: Three Techniques to Perform Single Cell Gene Expression and Genome Sequencing Single Molecule DNA Sequencing

Curator: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/07/04/genomic-diagnostics-three-techniques-to-perform-single-cell-gene-expression-and-genome-sequencing-single-molecule-dna-sequencing/

 

4.2.4   Three Technology Leaders in Single Cell Sequencing: 10X Genomics, Illumina and MissionBio

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/05/29/three-technology-leaders-in-single-cell-sequencing-10x-genomics-illumina-and-missionbio/

 

4.2.5   scPopCorn: A New Computational Method for Subpopulation Detection and their Comparative Analysis Across Single-Cell Experiments

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/07/16/scpopcorn-a-new-computational-method-for-subpopulation-detection-and-their-comparative-analysis-across-single-cell-experiments/

 

 

4.2.6   Nano-guided cell networks: new methods to detect intracellular signaling and implications

Curator: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2019/10/15/nano-guided-cell-networks-new-methods-to-detect-intracellular-signaling-and-implications/

 

4.3 Clinical Aspects

 

Hypergraph Plot #26 and Tree Diagram #26

for 4.3 based on 7 articles & on 10 keywords

 

cells, mutation, sequencing, data, cancer, heterogeneity,

tumor, mutations, gene, immune

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 4.3

 

4.3.1 Using single cell sequencing data to model the evolutionary history of a tumor.

Kim KI, Simon R.

BMC Bioinformatics. 2014 Jan 24;15:27. doi: 10.1186/1471-2105-15-27.

 

4.3.2   eProceedings 2019 Koch Institute Symposium – 18th Annual Cancer Research Symposium – Machine Learning and Cancer, June 14, 2019, 8:00 AM-5:00 PM ET MIT Kresge Auditorium, 48 Massachusetts Ave, Cambridge, MA

Real Time Press Coverage: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2019/03/12/2019-koch-institute-symposium-machine-learning-and-cancer-june-14-2019-800-am-500-pmet-mit-kresge-auditorium-48-massachusetts-ave-cambridge-ma/

 

4.3.3   The Impact of Heterogeneity on Single-Cell Sequencing

Samantha L. Goldman 1,2, Matthew MacKay 1,2, Ebrahim Afshinnekoo 1,2,3, Ari M. Melnick4, Shuxiu Wu5,6 and Christopher E. Mason 1,2,3,7*

https://www.frontiersin.org/articles/10.3389/fgene.2019.00008/full

 

4.3.4   Single-cell approaches to immune profiling

https://www.nature.com/articles/d41586-018-05214-w

 

4.3.5   Single-cell sequencing made simple. Data from thousands of single cells can be tricky to analyse, but software advances are making it easier.

by Jeffrey M. Perkel

https://www.nature.com/news/single-cell-sequencing-made-simple-1.22233

 

4.3.6  Single-cell RNA-seq helps in finding intra-tumoral heterogeneity in pancreatic cancer

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/07/21/single-cell-rna-seq-helps-in-finding-intra-tumoral-heterogeneity-in-pancreatic-cancer/

 

4.3.7 Cancer Genomics: Multiomic Analysis of Single Cells and Tumor Heterogeneity

Curator: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2019/10/15/cancer-genomics-multiomic-analysis-of-single-cells-and-tumor-heterogeneity/

 

4.4 Business and Legal

 

Hypergraph Plot #27 and Tree Diagram #27

for 4.4 based on 2 articles & on 10 keywords

 

cells, platform, sequencing, isolation, endotoxin, aging,

lifespan, dna, clonal, cellplate

 

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 4.4

 

4.4.1   iBioChips integrate diagnostic assays and cellular engineering into miniaturized chips that achieve cutting-edge sensitivity and high-throughput. We have resolved traditional biotech challenges with innovative biochip approaches

https://ibiochips.com/?gclid=Cj0KCQjwuLPnBRDjARIsACDzGL0wb6u79VHHkftodfApMYs-oxI-5cOZIBUaELdmd2wDOIk3W0OQg2caAqMyEALw_wcB

 

4.4.2   Targeted Single-Cell Solutions for High Impact Applications – Mission Bio’s Tapestri® Platform is the only technology that provides single-cell targeted DNA sequencing at single-base resolution.

https://missionbio.com/?gclid=Cj0KCQjwuLPnBRDjARIsACDzGL3WvKv_DLMU8Szwqw3172AvKnAhonkEZL04wOKKDW7LlQpowqL7cxQaAoN6EALw_wcB

 

 

Text Analysis with NLP of the Original

Genomics Volume 2, Part 5:

 

Evolution Biology Genomics Modeling

@Feldman Lab, Stanford University

One article is included in Part 5

 

5.1   Human Genomic Variation, Population Diversity, and Genome-Wide Associations

Author: Marcus W. Feldman, PhD

https://pharmaceuticalintelligence.com/biomed-e-books/genomics-orientations-for-personalized-medicine/volume-two-genomics-methodologies-ngs-bioinformatics-simulations-and-the-genome-ontology/

 

5.1 Human Genomic Variation, Population Diversity, Genome-Wide Applications

Hypergraph Plot #28 and Tree Diagram #28

for 5.1 based on 2 articles & on 15 keywords

 

populations, genetic, evolution, variation, gwas, snps,

association, heritability, ancestry, african, variants,

traits, humans, genomic, genes

 

 

 

PART 5.1: HYPER-GRAPH and TREE PLOT DIAGRAM INTERPRETATION by Prof. Marcus Feldman

The hypergraph is in general not very informative concerning the content of the article. The following assessments also apply to the tree plot.

  1. The “humans” branch leading to homo and groups is partly satisfactory because the article did discuss Homo sapiens and genetic similarity and differences between human groups. It also mentioned migration among human populations.
  2. The “evolution” branch is less useful because it is obvious that evolution is a biological process. It can also be a cultural process. The process is descent with modification and includes mutation, natural selection, and migration. Just saying it is a process is rather useless.
  3. “Association”. The secondary links here are quite meaningless; memory and remembering should not be separated, and neither has to do with human genomic variation and/or evolution. Social activity might result in cultural evolution, but it is not a valid secondary link.
  4. “Ancestry” is the only node that makes sense in the context of the article. It is a result of inheritance, it does comprise a hereditary pattern, and it can be quantified by a family tree.
  5. “Variation”. This is the most useless of all the categories. There is no reason for “dance” to be a secondary link. Although variation among individuals and populations does imply that something has changed, making change a secondary to variation is not helpful. Activity is not at all informative as a secondary link.

The remarks above concerning the hypergraph apply equally well to the tree plot, which is, of course, equivalent to the hypergraph.

 

 

The Original Genomics Volume 2, Part 6:

Simulation Modeling in Genomics

Not included in Text Analysis with NLP,

Genomics, Volume 3

 

Text Analysis with NLP of the Original

Genomics Volume 2, Part 7:

 

Applications of Genomics:

Genotypes, Phenotypes and Complex Diseases

7.1 Genome-wide associations with complex diseases (GWAS)

 

Hypergraph Plot #29 and Tree Diagram #29

for 7.1 based on 3 articles & on 13 keywords

 

disease, variants, genetic, risk, sequencing, genome, gene,

loci, diabetes, depression, heart, genetics, variant

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 7.1

 

7.1.1 Crowdsourcing Genetic Data Yields Discovery of DNA loci associated with Major Depressive Disorder (MDD) in European Descendants

Reporter: Kelly Perlman

https://pharmaceuticalintelligence.com/2016/08/09/crowdsourcing-genetic-data-yields-discovery-of-dna-loci-associated-with-mdd-in-european-descendants/

 

7.1.2 Finding the Genetic Links in Common Disease: Caveats of Whole Genome Sequencing Studies

Writer and Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2013/05/15/finding-the-genetic-links-in-common-disease-caveats-of-whole-genome-sequencing-studies/

 

7.1.3   23andMe Genome-Wide Association Study on Human propensity to Get up early or Sleep in the Morning

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/02/02/23andme-genome-wide-association-study-on-human-propensity-to-get-up-early-or-sleep-in-the-morning/

 

7.2 Non-coding DNA and phenotypes—including diseases like cancer

 

Hypergraph Plot #30 and Tree Diagram #30

for 7.2 based on 2 articles & on 12 keywords

 

cells, cancer, protein, dna, genes, tumor, immune, rna,

humans, biology, genome, drug

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

 

List of articles included in 7.2

 

7.2.1 Novel Discoveries in Molecular Biology and Biomedical Science

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/05/30/novel-discoveries-in-molecular-biology-and-biomedical-science/

 

7.2.2 Genomic expression carried over from Neanderthal DNA

Larry H. Bernstein, MD, FCAP, Curator

https://pharmaceuticalintelligence.com/2016/02/13/genomic-expression-carried-over-from-neanderthal-dna/

 

7.2.3 Junk DNA and Breast Cancer

Larry H. Bernstein, MD, FCAP, Curator

https://pharmaceuticalintelligence.com/2016/02/02/junk-dna-and-breast-cancer/

 

7.3  Transcriptomic and ‘omic associations with phenotypes including cancer and rare variant diseases

 

Hypergraph Plot #31 and Tree Diagram #31

for 7.3 based on 4 articles & on 11 keywords

 

cells, variants, cancer, genome, disease, sequencing,

gene, dna, biomarkers, subpopulations, rna

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 7.3

 

7.3.1 scPopCorn: A New Computational Method for Subpopulation Detection and their Comparative Analysis Across Single-Cell Experiments

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/07/16/scpopcorn-a-new-computational-method-for-subpopulation-detection-and-their-comparative-analysis-across-single-cell-experiments/

 

7.3.2 Complex rearrangements and oncogene amplification revealed by long-read DNA and RNA sequencing of a breast cancer cell line

Reporter: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2019/08/14/complex-rearrangements-and-oncogene-amplification-revealed-by-long-read-dna-and-rna-sequencing-of-a-breast-cancer-cell-line/

 

7.3.3  Live Conference Coverage @Medcitynews Converge 2018 Philadelphia: Early Diagnosis Through Predictive Biomarkers, NonInvasive Testing

Curator: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2018/07/11/live-conference-coverage-medcitynews-converge-2018-philadelphia-early-diagnosis-through-predictive-biomarkers-noninvasive-testing/

 

7.3.4 Millions of inherited DNA differences – which ones matter: NIH Grants in Genomics to research Disease Risk

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2015/09/21/millions-of-inherited-dna-differences-which-ones-matter-nih-grants-in-genomics-to-research-disease-risk/

 

7.4 Applications of Bioinformatic Analysis of ‘Omic Data

 

Hypergraph Plot #32 and Tree Diagram #32

for 7.4 based on 3 articles & on 12 keywords

 

thickspace, variants, multifractal, fractal, genomic, genomes,

dna, bioinformatics, variant, sequences, regions, genes

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 7.4

 

7.4.1   A Nonlinear Methodology to Explain Complexity of the Genome and Bioinformatic Information

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/05/01/a-nonlinear-methodology-to-explain-complexity-of-the-genome-and-bioinformatic-information/

 

7.4.2   Bioinformatics Tool Review: Genome Variant Analysis Tools

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2018/10/23/bioinformatics-tool-review-genome-variant-analysis-tools/

 

7.4.3  Bioinformatic Tools for RNA-Seq Analysis

Curator: Stephen J. Williams, Ph.D

https://pharmaceuticalintelligence.com/2019/12/18/bioinformatic-tools-for-rnaseq-a-curation/

7.5 Population-level genomics and the meaning of group differences

 

Hypergraph Plot #33 and Tree Diagram #33

for 7.5 based on 5 articles & on 12 keywords

 

populations, mutation, variation, loci, diversity, chromosome,

genome, inclusion, locus, genetic, differences, snps

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 7.5

 

7.5.1  Genomics and Evolution

Author: Marcus W. Feldman, PhD

https://pharmaceuticalintelligence.com/2013/02/14/genomics-and-evolution/

 

7.5.2 Tandem Repeats, with Application to Human Population-Divergence Time

Larry H. Bernstein, MD, FCAP, Curator

https://pharmaceuticalintelligence.com/2015/11/20/tandem-repeats-with-application-to-human-population-divergence-time/

 

7.5.3 Gender affects the prevalence of the cancer type

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/04/02/gender-affects-the-prevalence-of-the-cancer-type/

 

7.5.4 Access to Precision Medicine: Genomics is failing on Diversity

Reporter: Aviva Lev- Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/10/13/access-to-precision-medicine-genomics-is-failing-on-diversity/

 

7.5.5 Diversity and Health Disparity Issues Need to be Addressed for GWAS and Precision Medicine Studies

Curator: Stephen J. Williams, PhD

https://pharmaceuticalintelligence.com/2019/12/22/diversity-and-health-disparity-issues-need-to-be-addressed-for-gwas-and-precision-medicine-studies/

7.6 Targeting drugs for complex diseases

 

Hypergraph Plot #34 and Tree Diagram #34

for 7.6 based on 2 articles & on 15 keywords

 

mrtx, kras, cells, krasgc, inhibition, tumor, signaling, combination,

erk, treatment, dose, mutant, protein, antitumor, pathway

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

 

 

TREE DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 7.6

 

7.6.1 Anti-tumor necrosis factor drugs (TNF inhibitors) is the treatment for otulipenia, a new inflammatory disease discovered by NIH researchers using NGS

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/08/22/anti-tumor-necrosis-factor-drugs-tnf-inhibitors-is-the-treatment-for-otulipenia-a-new-inflammatory-disease-discovered-by-nih-researchers-using-ngs/

 

7.6.2  New Mutant KRAS Inhibitors Are Showing Promise in Cancer Clinical Trials: Hope For the Once ‘Undruggable’ Target

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2019/11/11/new-mutant-kras-inhibitors-are-showing-promise-in-cancer-clinical-trials-hope-for-the-once-undruggable-target/

 

Text Analysis with NLP of Original

Genomics Volume 2, Part 8:

Epigenomics and Genomic Regulation

 

Introduction to Part 8: Epigenomics and Genomic Regulation – Voice of Professor Williams

See Below

https://pharmaceuticalintelligence.com/biomed-e-books/series-a-e-books-on-cardiovascular-diseases/volume-three-etiologies-of-cardiovascular-diseases-epigenetics-genetics-genomics/

8.1  Genomic Controls on Epigenomics

 

8.1.1 Series A: e-Books on Cardiovascular Diseases, Series A Content Consultant: Justin D Pearlman, MD, PhD, FACC

VOLUME THREE, Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics, Larry H Bernstein, MD, FCAP, Senior Editor, Author and Curator and Aviva Lev-Ari, PhD, RN, Editor and Curator

http://www.amazon.com/dp/B018PNHJ84

 

 

8.2  The ENCODE project and gene regulation

 

Hypergraph Plot #35 and Tree Diagram #35

for 8.2 based on 6 articles & on 18 keywords

 

signature, genome, encode, cancer, dna, types, cells, protein,

genes, mutations, regions, regulatory, transcription,

binding, elements, etiology, sites, functional

 

HYPERGRAPH INTERPRETATION
TREE PLOT DIAGRAM INTERPRETATION

 

 

List of articles included in 8.2

 

8.2.1  Bioinformatic Tools for Cancer Mutational Analysis: COSMIC and Beyond

Curator: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2015/12/02/bioinformatic-tools-for-cancer-mutational-analysis-cosmic-and-beyond-2/

 

8.2.2   ENCODE (Encyclopedia of DNA Elements) Program: ‘Tragic’ Sequestration Impact on NHGRI Programs

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2013/09/18/encode-encyclopedia-of-dna-elements-program-tragic-sequestration-impact-on-nhgri-programs/

 

8.2.3   Reveals from ENCODE project will invite high synergistic collaborations to discover specific targets

Author and Reporter: Anamika Sarkar, Ph.D

https://pharmaceuticalintelligence.com/2012/09/30/reveals-from-encode-project-will-lead-to-confusion-or-specific-target/

 

8.2.4   ENCODE: the key to unlocking the secrets of complex genetic diseases

Author: Ritu Saxena, Ph.D.

https://pharmaceuticalintelligence.com/2012/09/26/encode-the-key-to-unlocking-the-secrets-of-complex-genetic-diseases/

 

8.2.5   Impact of evolutionary selection on functional regions: The imprint of evolutionary selection on ENCODE regulatory elements is manifested between species and within human populations

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2012/09/20/impact-of-evolutionary-selection-on-functional-regions-the-imprint-of-evolutionary-selection-on-encode-regulatory-elements-is-manifested-between-species-and-within-human-populations/

 

8.2.6   ENCODE Findings as Consortium

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2012/09/10/encode-findings-as-consortium/

 

8.3  Small interfering RNAs and gene expression

 

 

Hypergraph Plot #36 and Tree Diagram #36

for 8.3 based on 5 articles & on 12 keywords

 

cancer, mrna, cells, rna, vaccines, protein, micrornas, immune,

dna, therapeutic, tfna, polyneuropathy

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 8.3

 

8.3.1 Moderna Therapeutics Deal with Merck: Are Personalized Vaccines here?

Curator & Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2016/08/11/moderna-therapeutics-deal-with-merck-are-personalized-vaccines-here/

 

8.3.2   IsomicroRNA

Larry H. Bernstein, MD, FCAP, Curator

https://pharmaceuticalintelligence.com/2016/02/18/isomicrorna/

 

8.3.3  An Intelligent DNA Nanorobot to Fight Cancer by Targeting HER2 Expression

Reporter and Curator: Dr. Sudipta Saha, Ph.D.

https://pharmaceuticalintelligence.com/2019/07/24/an-intelligent-dna-nanorobot-to-fight-cancer-by-targeting-her2-expression/

 

8.3.4  Exosomes: Natural Carriers for siRNA Delivery using extracellular vesicles through endocytic pathway.

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2017/04/24/exosomes-natural-carriers-for-sirna-delivery/

 

8.3.5  Alnylam Announces First-Ever FDA Approval of an RNAi Therapeutic, ONPATTRO™ (patisiran) for the Treatment of the Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis in Adults

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2018/08/13/alnylam-announces-first-ever-fda-approval-of-an-rnai-therapeutic-onpattro-patisiran-for-the-treatment-of-the-polyneuropathy-of-hereditary-transthyretin-mediated-amyloidosis-in-adults/

 

8.4  Epigenomics in Cancer

 

Hypergraph Plot #37 and Tree Diagram #37

for 8.4 based on 4 articles & on 15 keywords

 

cells, cancer, protein, methylation, dna, rna, expression,

epigenetic, gene, pyruvate, glutamine, metabolism,

molecules, stem, human

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 8.4

 

8.4.1 Deciphering the Epigenome

Curator: Larry H. Bernstein, MD, FCAP

https://pharmaceuticalintelligence.com/2016/01/28/deciphering-the-epigenome/

 

 8.4.2 Methylation and cancer epigenomics

Larry H. Bernstein, MD, FCAP, Curator

https://pharmaceuticalintelligence.com/2016/02/19/methylation-and-cancer-epigenomics/

 

 8.4.3 A New Potential Target for Pancreatic Cancer Treatment: Rapid Screening Technique finds Gene Defending Tumors from DNA Damage @M. D. Anderson Cancer Center

Reporter: Aviva Lev-Ari, PhD, RN

https://pharmaceuticalintelligence.com/2016/07/28/a-new-potential-target-for-pancreatic-cancer-treatment-rapid-screening-technique-finds-gene-defending-tumors-from-dna-damage-md-anderson-cancer-center/

 

8.4.4 Is the Warburg effect an effect of deregulated space occupancy of methylome?

Larry H. Bernstein and Radoslav Bozov, co-curation

https://pharmaceuticalintelligence.com/2016/02/15/is-the-warburg-effect-is-an-effect-of-deregulated-space-occupancy-of-methylome/

8.5  Environmental Epigenomics

 

Hypergraph Plot #38 and Tree Diagram #38

for 8.5 based on 4 articles & on 11 keywords

 

epa, chemical, toxrefdb, toxicity, toxicology, kes, gene,

environmental, sperm, air, safety

 

HYPERGRAPH INTERPRETATION

 

 

 

 

 

 

 

TREE PLOT DIAGRAM INTERPRETATION

 

 

 

 

 

 

 

 

List of articles included in 8.5

 

8.5.1   BioInformatic Resources at the Environmental Protection Agency: Tools and Webinars on Toxicity Prediction

Curator Stephen J. Williams Ph.D.

https://pharmaceuticalintelligence.com/2019/05/11/bioinformatic-resources-at-the-environmental-protection-agency-tools-and-webinars-on-toxicity-prediction/

 

8.5.2   Live 2:30-4:30 PM  Mediterranean Diet and Lifestyle: A Symposium on Diet and Human Health:  October 19, 2018

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2018/10/20/live-230-430-pm-mediterranean-diet-and-lifestyle-a-symposium-on-diet-and-human-health-october-19-2018/

 

8.5.3   Live 12:00 – 1:00 P.M  Mediterranean Diet and Lifestyle: A Symposium on Diet and Human Health : October 19, 2018

Reporter: Stephen J. Williams, Ph.D.

https://pharmaceuticalintelligence.com/2018/10/19/live-1200-100-p-m-mediterranean-diet-and-lifestyle-a-symposium-on-diet-and-human-health-october-19-2018/

 

8.5.4 Decline in Sperm Count – Epigenetics, Well-being and the Significance for Population Evolution and Demography

Contributors of Co-Curation

Dr. Marc Feldman, Expert Opinion on the significance of Sperm Count Decline on the Future of Population Evolution and Demography

Dr. Sudipta Saha, Effects of Sperm Quality and Quantity on Human Reproduction

Dr. Aviva Lev-Ari, Psycho-Social Effects of Poverty, Unemployment and Epigenetics on Male Well-being, Physiological Conditions affecting Sperm Quality and Quantity

https://pharmaceuticalintelligence.com/2017/08/24/decline-in-sperm-count-epigenetics-well-being-and-the-significance-for-population-evolution-and-demography/

 

In summary to this volume, five comments of note are repeated here from the Original Book and from the New Genre, Genomics Volume 2, PART A & PART C because of their significance:

 

Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS & BioInformatics, Simulations and the Genome Ontology

 

Comment #1: 

  • No other book covers the same topics in a single volume

Comment #2:

  • No other book incorporates 74 e-Proceedings created in real time by the Book’s authors and editors at conferences on Genomics

Comment #3:

  • No other book incorporates four collections of Tweets representing quotes from speakers at global leading conferences on Genomics

Comment #4:

  • No other book has 13 locations of Videos and Audio Podcasts that serve to enrich the e-Reader’s experience

Comment #5:

  • No other book has 326 articles on the topics covered and included in the title of this Book: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS & BioInformatics, Simulations and the Genome Ontology

 

The e-Reader is encouraged to read the Preface, the Introduction and the Epilogue to Genomics Volume 2

 

  • Original Volume Two:

Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS and BioInformatics, Simulations and the Genome Ontology

On Amazon.com since 12/28/2019

https://www.amazon.com/dp/B08385KF87

 

AND

 

the e-Reader is encouraged to continue to Genomics Volume 1

Genomics Orientations for Personalized Medicine

VOLUME ONE

On Amazon.com since 23/11/2015

http://www.amazon.com/dp/B018DHBUO6

NEW GENRE Genomics, Volume Three:

Appendix to this volume

 

Appendix – Wolfram Code

for Hypergraph Plots & for Tree Diagram Plots 

NLP Code writing for Parts 1,2,3,4,5,7,8

by

Madison Davis

 

Code used in production of Hyper-graph Plots at the Book Part Level

 

Hypergraph Plot #1

for 1.1.1 based on 16 articles & on 14 keywords

wordSheet ={

protein,cancer,dna,gene,genes,rna,survival,immune,tumor,research,patients,human,

genome,expression

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #2

for 1.1.2

based on 17 articles & on 12 keywords

wordSheet ={

cancer,mutations,patients,gene,disease,genetic,mutation,data,clinical,tumor,genes,

protein

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #3

for 1.1.3

based on 21 articles & on 14 keywords

wordSheet ={

protein,dna,cancer,cells,information,gene,hdx,mass,sequence,research,chemical,

analysis,approach,complexes

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #4

for 1.1.4

based on 2 articles & on 18 keywords

wordSheet ={

sequencing,medicine,hospital,genes,women,genome,harvard,genetic,conference,

research,rare,medical,genetics,disorder,department,bipolar,autism,variations

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #5

for 1.2.1

based on 18 articles & on 16 keywords

wordSheet ={

data,cancer,cells,signature,analysis,genome,information,variants,gene,research,

genomic,learning,human,frequency,features,system

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #6

for 1.2.2

based on 18 articles & on 19 keywords

wordSheet ={

cancer,cells,genome,analysis,research,drug,protein,human,information,gene,

bioinformatics,genomic,genes,clinical,medicine,development,dna,genomics,world

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #7

for 1.2.3

based on 11 articles & on 12 keywords

wordSheet ={

dna,cancer,protein,source,gene,search,amino,health,medicine,cells,genome,editing

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #8

for 1.2.4

based on 5 articles & on 14 keywords

wordSheet ={

genetic,sequencing,research,gene,clinical,pacbio,genome,reproductive,disease,

diagnostics,medicine,sinai,ngs,results

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #9

for 1.3

based on 11 articles & on 16 keywords

wordSheet ={

cells,medicine,cancer,personalized,clinical,gene,medical,patients,research,sequencing,

health,therapy,pharma,drug,genetic,genome

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #10

for 1.4

based on 18 articles & on 15 keywords

wordSheet ={

oncology,healthcare,cancer,data,cells,verily,research,sequencing,conference,technology,horizon,health,life,gene,AI

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #11

for 2.1.1

based on 22 articles & on 17 keywords

wordSheet ={

cells,crispr,cas,gene,beta,figure,dna,protein,editing,genome,cancer,target,ripk,rna,

system,genes,expression

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #12

for 2.1.2

based on 8 articles & on 18 keywords

wordSheet ={

crispr,cas,cells,gene,genome,dna,rnai,genes,rna,research,protein,genetic,editing,

disease,system,target,human,technology

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #13

for 2.1.3

based on 15 articles & on 17 keywords

wordSheet ={

crispr,cas,protein,cells,gene,genome,editing,dna,rna,disease,genes,doudna,cancer,

human,target,mit,technology

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #14

for 2.1.4 based on 6 articles & on 19 keywords

wordSheet ={

gene,crispr,human,editing,cas,genome,technology,cells,research,doudna,genetic,

embryos,genes,science,engineering,dna,cancer,nature,germline

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #15

for 2.1.5

based on 28 articles & on 16 keywords

wordSheet ={

crispr,cells,gene,cas,editing,dna,genome,technology,rna,research,genes,human,doudna,science,genetic,engineering

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #16

for 2.2

based on 27 articles & on 16 keywords

wordSheet ={

cas,crispr,gene,dna,protein,expression,stem,rna,target,genome,editing,genes,cancer,

system,research,human

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #17

for 2.3

based on 9 articles & on 19 keywords

wordSheet ={

crispr,gene,cas,editing,cells,disease,genome,dna,human,genetic,target,therapy,ttr,

protein,research,genes,system,amyloid,technology

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #18

for 2.4

based on 20 articles & on 16 keywords

wordSheet ={

crispr,patent,cas,editing,institute,patents,gene,berkeley,therapeutics,technology,cells,

interference,intellia,genomics,biotech,doudna

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #19

for 3.1 based on 8 articles & on 13 keywords

wordSheet ={

ai,data,hms,health,mgh,medicine,care,clinical,healthcare,ballroom,patient,radiology,

innovation

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #20

for 3.2

based on 9 articles & on 14 keywords

wordSheet ={

cells,cancer,gene,schizophrenia,research,protein,brain,frontal,imaging,patients,disease,dna,researchers,system

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #21

for 3.3

based on 23 articles & on 16 keywords

wordSheet ={

data,cancer,patients,ai,clinical,exon,patient,gene,learning,analysis,splicing,health,cells,

rna,clinicians,imaging

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #22

for 3.4

based on 16 articles & on 12 keywords

wordSheet ={

ai,data,healthcare,patients,technology,world,partners,medical,digital,clinical,access,

research

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #23

for 3.5

based on 9 articles & on 16 keywords

wordSheet ={

cancer,risk,brain,breast,model,mri,data,molecular,mtv,density,women,mdm,image,

aging,analysis,tissue

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #24

for 4.1

based on 9 articles & on 17 keywords

wordSheet ={

cells,human,single,atlas,genomics,cellular,science,institute,nature,cancer,sequencing,

disease,map,immune,biology,body,researchers

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #25

for 4.2

based on 6 articles & on 16 keywords

wordSheet ={

cells,single,ai,sequencing,molecular,information,expression,fluorescence,protein,rna,

streptavidin,population,surface,output,magnetic,seq

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #26

for 4.3

based on 7 articles & on 12 keywords

wordSheet ={

cells,single,mutation,sequencing,data,cancer,heterogeneity,tumor,analysis,mutations,

gene,immune

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #27

for 4.4

based on 2 articles & on 17 keywords

wordSheet ={

cells,single,platform,analysis,sequencing,products,rare,isolation,endotoxin,aging,view,

tapestri,lifespan,dna,clonal,cellplate,mission

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #28

for 5.1

based on 1 article & on 17 keywords

wordSheet ={

populations,genetic,human,population,variation,heritability,snps,gwas,traits,genome,

african,genomic,ancestry,polygenic,feldman,diversity,data

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #29

for 7.1

based on 3 articles & on 18 keywords

wordSheet ={

disease,variants,genetic,risk,sequencing,genome,gene,studies,rare,loci,genes,diseases,diabetes,depression,heart,genetics,variant,personalized

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #30

for 7.2

based on 2 articles & on 18 keywords

wordSheet ={

cells,cancer,protein,dna,gene,fibonacci,genes,tumor,human,data,immune,research,rna,

structure,humans,biology,genome,drug

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #31

for 7.3

based on 4 articles & on 14 keywords

wordSheet ={

cells,variants,cancer,genome,disease,sequencing,gene,dna,biomarkers,subpopulations,

rna,diseases,researchers,data

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #32

for 7.4

based on 3 articles & on 18 keywords

wordSheet ={

thickspace,genome,variants,gene,information,tools,multifractal,fractal,genomic,

genomes,dna,bioinformatics,variant,sequences,human,regions,data,genes

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #33

for 7.5

based on 5 articles & on 15 keywords

wordSheet ={

populations,mutation,population,variation,loci,human,diversity,data,chromosome,

genome,inclusion,locus,genetic,differences,snps

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #34

for 7.6

based on 2 articles & on 18 keywords

wordSheet ={

mrtx,kras,cells,krasgc,inhibition,tumor,signaling,combination,erk,treatment,dose,

mutant,demonstrated,protein,antitumor,activity,single,pathway

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #35

for 8.2

based on 6 articles & on 23 keywords

wordSheet ={

signature,genome,encode,cancer,dna,human,types,gene,data,cells,mutational,protein,

genes,mutations,regions,regulatory,transcription,binding,elements,associated,aetiology,sites,functional

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #36

for 8.3

based on 5 articles & on 17 keywords

wordSheet ={

cancer,mrna,cells,rna,moderna,vaccines,protein,micrornas,vaccine,immune,treatment,

dna,therapeutic,personalized,merck,tfna,polyneuropathy

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #37

for 8.4

based on 4 articles & on 16 keywords

wordSheet ={

cells,cancer,protein,methylation,dna,rna,expression,epigenetic,gene,pyruvate,

glutamine,metabolism,epigenetics,molecules,stem,human

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

Hypergraph Plot #38

for 8.5

based on 4 articles & on 18 keywords

wordSheet ={

data,epa,chemical,information,toxrefdb,toxicity,toxicology,chemicals,kes,gene,

environmental,national,sperm,air,si,safety,mies,mesh

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

edgeList = Append[edgeList,Prepend[words1, “”]] ;

For[i = 1, i <= Length[words1], i++,  edgeList = Append[edgeList, Append[broadTerms[[i]], words1[[i]]]]];

ResourceFunction[“HypergraphPlot”][edgeList, VertexSize -> 0.01, VertexLabels -> Automatic, PlotTheme -> “Detailed”, SubsetEdge -> False, SubsetBoundaryScale -> 7, VertexStyle ->

Red,”BaseLayout” -> “RadialEmbedding”,”SubsetEdgeStyle” -> ColorData[100, “ColorList”]]

 

 

Code used in production of Tree Diagram Plots

 

Tree Diagram Plot #1

for 1.1.1 based on 16 articles & on 14 keywords

wordSheet ={

protein,cancer,dna,gene,genes,rna,survival,immune,tumor,research,patients,human,

genome,expression

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.1.1” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #2

for 1.1.2

based on 17 articles & on 12 keywords

wordSheet ={

cancer,mutations,patients,gene,disease,genetic,mutation,data,clinical,tumor,genes,

protein

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.1.2” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #3

for 1.1.3

based on 21 articles & on 14 keywords

wordSheet ={

protein,dna,cancer,cells,information,gene,hdx,mass,sequence,research,chemical,

analysis,approach,complexes,

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.1.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #4

for 1.1.4

based on 2 articles & on 18 keywords

wordSheet ={

sequencing,medicine,hospital,genes,women,genome,harvard,genetic,conference,

research,rare,medical,genetics,disorder,department,bipolar,autism,variations

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.1.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #5

for 1.2.1

based on 18 articles & on 16 keywords

wordSheet ={

data,cancer,cells,signature,analysis,genome,information,variants,gene,research,

genomic,learning,human,frequency,features,system

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.2.1” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #6

for 1.2.2

based on 18 articles & on 19 keywords

wordSheet ={

cancer,cells,genome,analysis,research,drug,protein,human,information,gene,

bioinformatics,genomic,genes,clinical,medicine,development,dna,genomics,world

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.2.2” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #7

for 1.2.3

based on 11 articles & on 12 keywords

wordSheet ={

dna,cancer,protein,source,gene,search,amino,health,medicine,cells,genome,editing

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.2.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Hypergraph Plot #8

for 1.2.4

based on 5 articles & on 14 keywords

wordSheet ={

genetic,sequencing,research,gene,clinical,pacbio,genome,reproductive,disease,

diagnostics,medicine,sinai,ngs,results

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.2.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #9

for 1.3

based on 11 articles & on 16 keywords

wordSheet ={

cells,medicine,cancer,personalized,clinical,gene,medical,patients,research,sequencing,

health,therapy,pharma,drug,genetic,genome

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #10

for 1.4

based on 18 articles & on 15 keywords

wordSheet ={

oncology,healthcare,cancer,data,cells,verily,research,sequencing,conference,technology,horizon,health,life,gene,AI

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 1.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #11

for 2.1.1

based on 22 articles & on 17 keywords

wordSheet ={

cells,crispr,cas,gene,beta,figure,dna,protein,editing,genome,cancer,target,ripk,rna,

system,genes,expression

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 2.1.1” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #12

for 2.1.2

based on 8 articles & on 18 keywords

wordSheet ={

crispr,cas,cells,gene,genome,dna,rnai,genes,rna,research,protein,genetic,editing,

disease,system,target,human,technology

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 2.1.2” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #13

for 2.1.3

based on 15 articles & on 17 keywords

wordSheet ={

crispr,cas,protein,cells,gene,genome,editing,dna,rna,disease,genes,doudna,cancer,

human,target,mit,technology

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 2.1.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #14

for 2.1.4 based on 6 articles & on 19 keywords

wordSheet ={

gene,crispr,human,editing,cas,genome,technology,cells,research,doudna,genetic,

embryos,genes,science,engineering,dna,cancer,nature,germline

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 2.1.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #15

for 2.1.5

based on 28 articles & on 16 keywords

wordSheet ={

crispr,cells,gene,cas,editing,dna,genome,technology,rna,research,genes,human,doudna,science,genetic,engineering

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 2.1.5” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #16

for 2.2

based on 27 articles & on 16 keywords

wordSheet ={

cas,crispr,gene,dna,protein,expression,stem,rna,target,genome,editing,genes,cancer,

system,research,human

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 2.2” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #17

for 2.3

based on 9 articles & on 19 keywords

wordSheet ={

crispr,gene,cas,editing,cells,disease,genome,dna,human,genetic,target,therapy,ttr,

protein,research,genes,system,amyloid,technology

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 2.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #18

for 2.4

based on 20 articles & on 16 keywords

wordSheet ={

crispr,patent,cas,editing,institute,patents,gene,berkeley,therapeutics,technology,cells,

interference,intellia,genomics,biotech,doudna

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 2.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #19

for 3.1 based on 8 articles & on 13 keywords

wordSheet ={

ai,data,hms,health,mgh,medicine,care,clinical,healthcare,ballroom,patient,radiology,

innovation

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 3.1” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #20

for 3.2

based on 9 articles & on 14 keywords

wordSheet ={

cells,cancer,gene,schizophrenia,research,protein,brain,frontal,imaging,patients,

disease,dna,researchers,system

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 3.2” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #21

for 3.3

based on 23 articles & on 16 keywords

wordSheet ={

data,cancer,patients,ai,clinical,exon,patient,gene,learning,analysis,splicing,health,cells,

rna,clinicians,imaging

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 3.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #22

for 3.4

based on 16 articles & on 12 keywords

wordSheet ={

ai,data,healthcare,patients,technology,world,partners,medical,digital,clinical,access,

research

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 3.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #23

for 3.5

based on 9 articles & on 16 keywords

wordSheet ={

cancer,risk,brain,breast,model,mri,data,molecular,mtv,density,women,mdm,image,

aging,analysis,tissue

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 3.5” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #24

for 4.1

based on 9 articles & on 17 keywords

wordSheet ={

cells,human,single,atlas,genomics,cellular,science,institute,nature,cancer,sequencing,

disease,map,immune,biology,body,researchers

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 4.1” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #25

for 4.2

based on 6 articles & on 16 keywords

wordSheet ={

cells,single,ai,sequencing,molecular,information,expression,fluorescence,protein,rna,

streptavidin,population,surface,output,magnetic,seq

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 4.2” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #26

for 4.3

based on 7 articles & on 12 keywords

wordSheet ={

cells,single,mutation,sequencing,data,cancer,heterogeneity,tumor,analysis,mutations,

gene,immune

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 4.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #27

for 4.4

based on 2 articles & on 17 keywords

wordSheet ={

cells,single,platform,analysis,sequencing,products,rare,isolation,endotoxin,aging,view,

tapestri,lifespan,dna,clonal,cellplate,mission

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 4.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #28

for 5.1

based on 1 article & on 17 keywords

wordSheet ={

populations,genetic,human,population,variation,heritability,snps,gwas,traits,genome,

african,genomic,ancestry,polygenic,feldman,diversity,data

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 5.1” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #29

for 7.1

based on 3 articles & on 18 keywords

wordSheet ={

disease,variants,genetic,risk,sequencing,genome,gene,studies,rare,loci,genes,diseases,diabetes,depression,heart,genetics,variant,personalized

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 7.1” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #30

for 7.2

based on 2 articles & on 18 keywords

wordSheet ={

cells,cancer,protein,dna,gene,fibonacci,genes,tumor,human,data,immune,research,rna,

structure,humans,biology,genome,drug

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 7.2” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #31

for 7.3

based on 4 articles & on 14 keywords

wordSheet ={

cells,variants,cancer,genome,disease,sequencing,gene,dna,biomarkers,subpopulations,

rna,diseases,researchers,data

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 7.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #32

for 7.4

based on 3 articles & on 18 keywords

wordSheet ={

thickspace,genome,variants,gene,information,tools,multifractal,fractal,genomic,

genomes,dna,bioinformatics,variant,sequences,human,regions,data,genes

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 7.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #33

for 7.5

based on 5 articles & on 15 keywords

wordSheet ={

populations,mutation,population,variation,loci,human,diversity,data,chromosome,

genome,inclusion,locus,genetic,differences,snps

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 7.5” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #34

for 7.6

based on 2 articles & on 18 keywords

wordSheet ={

mrtx,kras,cells,krasgc,inhibition,tumor,signaling,combination,erk,treatment,dose,

mutant,demonstrated,protein,antitumor,activity,single,pathway

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 7.6” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #35

for 8.2

based on 6 articles & on 23 keywords

wordSheet ={

signature,genome,encode,cancer,dna,human,types,gene,data,cells,mutational,protein,

genes,mutations,regions,regulatory,transcription,binding,elements,associated,aetiology,sites,functional

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 8.2” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #36

for 8.3

based on 5 articles & on 17 keywords

wordSheet ={

cancer,mrna,cells,rna,moderna,vaccines,protein,micrornas,vaccine,immune,treatment,

dna,therapeutic,personalized,merck,tfna,polyneuropathy

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 8.3” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #37

for 8.4

based on 4 articles & on 16 keywords

wordSheet ={

cells,cancer,protein,methylation,dna,rna,expression,epigenetic,gene,pyruvate,

glutamine,metabolism,epigenetics,molecules,stem,human

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 8.4” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

Tree Diagram Plot #38

for 8.5

based on 4 articles & on 18 keywords

wordSheet ={

data,epa,chemical,information,toxrefdb,toxicity,toxicology,chemicals,kes,gene,

environmental,national,sperm,air,si,safety,mies,mesh

};

topN = Length[wordSheet];

words = {};

For[i = 1, i <= topN, i++,

words = Append[words, ToString[wordSheet[[i]]]]];

Print[words];

maxN = 3;

broadTerms = {};

words1 = {};

words2 = {};

For[i = 1, i <= topN, i++,If[Length[Position[WordData[], Extract[words, i]]] > 0,

broadTerms = Append[broadTerms, Flatten[Values[WordData[Extract[words, i], “BroaderTerms”]]]];

words1 = Append[words1, Extract[words, i]], words2 = Append[words2, Extract[words, i]]]];

For[i = 1, i <= Length[broadTerms], i++, If[Length[broadTerms[[i]]] > maxN, broadTerms[[i]] = broadTerms[[i]][[1 ;; maxN]]]];

 

edgeList = {};

For[i = 1 , i <= Length[broadTerms], i++,  edgeList = Append[edgeList, broadTerms[[i]]]];

For[i = 1 , i <= Length[broadTerms], i++, For[j = 1, j <= Length[edgeList[[i]]], j++,  edgeList[[i]][[j]] = words1[[i]] -> edgeList[[i]][[j]]]];

For[i = 1 , i <= Length[words1], i++, edgeList = Append[edgeList, {“Chapter 8.5” -> words1[[i]]}]];

TreePlot[Flatten[edgeList], VertexSize -> 0.1, VertexLabels -> Automatic]

 

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