@BroadInstitute a shift from Permanently editing DNA to Temporarily revising RNA – An approach with promise for addressing the risk of developing Alzheimer’s by deactivating APOE4 – RESCUE: RNA Editing for Specific C to U Exchange, the platform builds on REPAIR: RNA Editing for Programmable A to I
Reporter: Aviva Lev-Ari, PhD, RN
- The RNA editors converted “the nucleotide base adenine to inosine, or letters A to I. Zhang and colleagues took the REPAIR fusion and evolved it in the lab until it could change cytosine to uridine, or C to U.”
- Using Cas13, Zhang’s team was able to take the APOE4 gene — believed to carry the added risk of spurring Alzheimer’s — and changed it to a benign APOE2.
RNA-guided DNA insertion with CRISPR-associated transposases
Other related articles on CRISPR derived Gene Editing for Gene Therapy published in this Open Access on Online Scientific Journal include the following:
Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS & BioInformatics, Simulations and the Genome Ontology
Forthcoming 12/2019, Volume Two
by
Prof. Marcus W. Feldman, PhD, Editor, Stanford University
Prof. Stephen J. Williams, PhD, Editor, Temple University
and Aviva Lev-Ari, PhD, RN, Editor, LPBI Group
Part 2: CRISPR for Gene Editing and DNA Repair
2.1 The Science – 77 articles
2.2 Technologies and Methodologies – 27 articles
2.3 Clinical Aspects – 9 articles
2.4 Business and Legal – 18 articles
Series B: Frontiers in Genomics Research
- VOLUME 1: Genomics Orientations for Personalized Medicine. On Amazon.com since 11/23/2015
Leave a Reply