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CRISPR-Cas9 Screening by Horizon Discovery, Cambridge, UK – HDx™ Reference Standards

May 3, 2016 by 2012pharmaceutical

CRISPR-Cas9 Screening by Horizon Discovery, Cambridge, UK – HDx™ Reference Standards

Reporters: David Orchard-Webb, PhD and Aviva Lev-Ari, PhD, RN

VIEW VIDEO

https://www.horizondiscovery.com/resources/webinars/how-crispr-cas9-screening-will-revolutionise-your-drug-development-programs?_cldee=ZC5vcmNoYXJkLXdlYmJAYmF0aC5lZHU%3d&utm_source=ClickDimensions&utm_medium=email&utm_campaign=201605%20Email%20-%207%20must-read%20CRISPR%20screening%20papers&urlid=3

Seven essential CRISPR screening papers

https://www.horizondiscovery.com/knowledge-base/essential-crispr-screening-papers?_cldee=ZC5vcmNoYXJkLXdlYmJAYmF0aC5lZHU%3d&utm_source=ClickDimensions&utm_medium=email&utm_campaign=201605%20Email%20-%207%20must-read%20CRISPR%20screening%20papers&urlid=1

CRISPR Screens… the beginning!
…moving beyond DNA cleavage
…changing the way we think about library design
…in primary immune cells
…pushing the technology in vivo
…improving screen resolution
So where next?

Read our short guide to CRISPR Screening	CLICK HERE
Watch our short introductory video to Horizon’s CRISPR screening platform	CLICK HERE
Explore our collection of ready-made sgRNA libraries available as part of our CRISPR screening service	CLICK HERE
Read about how we’ve combined KRAS isogenic cell lines, 3D cell culture and CRISPR screening for more definitive target validation	CLICK HERE

SOURCE

Immuno-Oncology Platform at Horizon Discovery

They have leveraged our cutting-edge technologies to build a ground-breaking platform for Immuno-Oncology drug discovery.
Their collection of high throughput assays allows you to rapidly identify single agents or combinations that affect T cell and natural killer (NK) cell function.

Gene-Editing in Immune Cells

Gene-editing in immune cells for your Immuno-Oncology project is now even faster than before. Leveraging the latest genome engineering tools, including CRISPR-Cas9, we’re able to precisely edit over 10 pre-characterized T-cell, B-cell, and monocytes lines.

CLICK HERE TO LEARN MORE

Gene-Editing for Immuno-Oncology

Power Your Immune-Oncology Projects with Custom Engineered Immune Cells

Gene-editing in immune cell lines can be challenging due to low targeting efficiency and difficulties in single cell derivation of suspension cells. Horizon has validated 10+ immune cell lines including THP-1, Jurkat and NALM-6 cells for gene-editing projects. CRISPR, rAAV and ZFN gene-editing technologies are available depending on project requirements.

Take advantage of the largest panel of pre-characterized immune cell lines available and benefit from Horizon’s exceptional knowhow and experience in completing over 2,000 gene-editing projects.

REQUEST MORE INFORMATION

SOURCE

https://www.horizondiscovery.com/research-services/immuno-oncology