Leaders in Pharmaceutical Business Intelligence (LPBI) Group

LIVE – Day 1, OCTOBER 18 @The 16th annual EmTech MIT – A Place of Inspiration, October 18-20, 2016, Cambridge, MA

Leaders in Pharmaceutical Business Intelligence (LPBI) Group, Boston

will cover in REAL TIME

The 16th annual EmTech MIT – A Place of Inspiration, October 18-20, 2016, Cambridge, MA

http://events.technologyreview.com/emtech/16/

In attendance, streaming LIVE using Social Media

Aviva Lev-Ari, PhD, RN

Editor-in-Chief

http://pharmaceuticalintelligence.com

@pharma_BI

@AVIVA1950

#emtechmit

2.1.5.8   LIVE – Day 1, OCTOBER 18 @The 16th annual EmTech MIT – A Place of Inspiration, October 18-20, 2016, Cambridge, MA, Volume 2 (Volume Two: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS and BioInformatics, Simulations and the Genome Ontology), Part 2: CRISPR for Gene Editing and DNA Repair

TUESDAY, OCTOBER 18, 2016

SOURCE

http://events.technologyreview.com/emtech/16/#section-schedule

• 8:00

  Registration & Breakfast
• 9:00

  Opening Remarks

  Emerging technologies, including:

  – Rethinking Energy

  — Rewrite Biology

  – Virtual Reality, Augmented Life

  – Artificial intelligence

  – Global Connectivity

  – Engineering a Healthy Planet

  – Spotlight talks on the 10 Breakthrough Technologies

  – Celebration of the 2016 Innovators Under 35
• 9:15

  Connecting for Greater Opportunity: Defining the Digital Era – from FaceBook 1.2 Billion customers around the World.
   – awareness affordability and infrastructure

  – 4G in US, Scandenavia, Japan, 3G in Europe, India 2G network, distribution of World population, Density of 1 sq Km, 1.6 Billion do not have mobile connections. Terragraph in Urban center to leapfrog UAVs to be used for connectivity. Terragraph Overview – ETHERNET CONNECTIVITY – GIGABIT – unlicensed 60GHz Spectrum, cloud computing, Open/R: IPv6 – Laser communication: comparable to fiber optics, 10s of Gbps per second, atmosphere absorbs and scatter: pointing and tracking system, Satellite. FACEBOOK Priorities: Density of Population, Gov’t will be favorable, population have not enough — #1 is INDIA, CHINA

• 9:45

  Innovators Under 35 Introduction – Brian Bergstein, Editor of Technology Review
• 10:00

  Meet Young Inventors

   – Blendoor – Stephanie Lampkin

  – MACH – Eshan Hoque Social Skills Trainer – My Automated Conversation Coach – ROCspeak.com

  – HandTalk – Ronaldo Tenorio – Deaf People 6 million people in Brazil, barrier between Hearing and Deaf people – sign language

  – Energy Systems Requires Water, Lake Mead by Kelly Sanders – energy vs bottle water
• 10:30

  Break & Networking
• 11:00 Antolio Regalado, Editor Biotech at MIT Technology Review

  Gene Therapy- A New Era of Medicine

  CEO & Founder, Intellia Therapeutics, Nessan Bermingham, PhD, 2018 there will be the product in Clinics

  – Gene Editing,

  – CRISPR Cas9 – immune system of Bacteria, using the mechanism in Bacteria for Human cells, Cellular level

  – cut DNA, coopting and shut down  – cut a piece of DNA convert a mutation,

  – injection of cRISPR protein – correction and the existing malformed is repaired no longer expressed

  – stem cells modifies and re-injected

  – KO: ATTR, AATD, HBV

  – Repair: AATD, HSCs

  – CAR-T cells

  – genetic engineering vs gene repair

  – equal access to therapy

  MGH – Cellular Immunotherapy Program – Marcella Maus, PhD on T-Cell research

  – blocking the checkpoints by antibo- dies, Use Tcells as drugs, scale the process, manufacturing process, recover T cell from Blood, from biopsy, who is responding and who does not respond? – Leukemia, CAR- T cells, multiple Myeloma, CURE is early to use but now it can be used COMBINATION of gen therapy follwoing gene editing and immunotherapy, CAR T- cell products for leukemia and lymphoma

• Katheirne High, Spark Therapeutics

• bring therapeutics to people – research to clinic
• DNA defective, engineered from AAV: Vector, DNA, Target tissue to delivery
• conjenetive blindness – investigational trial – get vector to retina by surgeon – clinical gain of function notices in 30 days group injected vs control group – impproved light sensitivity and mobility
• first gene therapy for blindness
• Himophilia – vector injected in the Liver where blood factors are produced
• models of therapeuitcs: Bone marrow transplantation,
• clinical cell therapy – low efficacy in adverse events – academic medical center and NIH interested vs Biotech
• as Clinical Trials were successful Biotech and Pharma got interested
• Access, pricing, reimbursement – How gene therapy is ONCE in a life time not an an infusion on a reccurent basis over many years – Hymophillia,  no pharmacological treatment to blindness
• duration of expression 5 years and counting in UK, follwoing gene therapy
• premature for cure

• 2:00

  The Robots Among Us –

  Stephanie Tellex, Brown University
  – 35 cm lens – Robots Distributive Lab @MIT – movie

  Sangbae Kim – Robots at Work – Robotics Mobility of the Future @MIT Mechanical Engineering

  – Physical interaction – BMW i3 Factory – automotive production

  – Robot design paradigms: Manufacturing (lack of compliance) vs construction (lack of efficiency)

  – Robot design for mobility – a robot that runs – MIT Cheeta Model

  – MIT  meche Biomimetic Robotics Lab – high torque, high impact mitigation

  – Hermes project:

  Karl Iagnemma – Intellignet Machines – nuTonomy – Singapore  – Autonomous machines deliver parcels and car is never distracted – driverless car

  – Robotics Lab at MIT – smart car, self driven cars, ability to learn from experience – 2017 – double fleet of drivers

• 12:30

  Lunch & Networking

  Meet Young Inventors under 35

• Jagdish Chaturvedi – ENTraview – device was licensed to Medtronic and to an Indian company, developed two more product InnAccel – Bangalor — product design company
• Wei Gao – Wearable Tech – Wearable Human Sweat Sensors
• Imaging Technologies by Muyinatu BiSI Bell Sounds – Amplitude vs Coherence
• Heather Bowerman – Hormonal Disease: Endometriosis 10% of Woman – microRNA DotLab

• 12:00

• 3:00 Meet the 2016 Innovators Under 35

1. Break & Networking

XPrize

• Google Lunar
• Qualcomm Tricorder
• Casio Cardon
• Shell Ocean Discovery