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SNP-based Study on high BMI exposure confirms CVD and DM Risks – no associations with Stroke

The “genetically instrumented” measure of high BMI exposure — calculated based on 93 single-nucleotide polymorphisms associated with BMI in prior genome-wide association studies — was associated with the following risks (odds ratios given per standard deviation higher BMI):

• Hypertension (OR 1.64, 95% CI 1.48-1.83)
• Coronary heart disease (CHD; OR 1.35, 95% CI 1.09-1.69)
• Type 2 diabetes (OR 2.53, 95% CI 2.04-3.13)
• Systolic blood pressure (β 1.65 mm Hg, 95% CI 0.78-2.52 mm Hg)
• Diastolic blood pressure (β 1.37 mm Hg, 95% CI 0.88-1.85 mm Hg)

• Primary Source

  JAMA Cardiology

  Source Reference: Lyall DM, et al “Association of body mass index with cardiometabolic disease in the UK biobank: A Mendelian randomization study” JAMA Cardiol 2017; doi:10.1001/jamacardio.2016.5804.

• Secondary Source

  JAMA Cardiology

  Source Reference: O’Donnell CJ “Harnessing genomic biobanks to understand obesity in cardiometabolic disease prospects and pitfalls” JAMA Cardiol 2017; doi:10.1001/jamacardio.2016.5805.

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