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Archive for March, 2014

Basel2014

14th ANNUAL
BIOTECH IN EUROPE FORUM
For Global Partnering & Investment

30th September – 1st October 2014 • Congress Center Basel

SACHS Associates, London

Conference website

http://www.sachsforum.com/basel14/index.html

 #Sachs14thBEF

Conference AGENDA

http://www.sachsforum.com/basel14/basel14-agenda.html

UPDATED on 8/4/2014 – SEE BELOW

http://www.sachsforum.com/basel14/Basel14-agenda.pdf

Sachs Associates is a London-based company, which organises and produces securities and emerging markets conferences in association with major exchanges and news agencies. Sachs Associates is dedicated to the highest quality standards in conferencing and, as a result, produces only a limited number of events each year. Sachs Associates investment conferences focus on Emerging Markets, European Equities and Technology, and are held in major financial centres such as London, New York and Zurich. Sachs Associates is focused on the practical benefits accruing from conference participation, the exchange of ideas and information, and the facilitating of business transactions.

 

  Financial/Advisory
Investors attending
the 2014 Forum
include:
AbbVie Biotech Ventures, Inc.
Advent Life Sciences
Aescap Venture Management BV
Aglaia Biomedical Ventures B.V.
Amgen Ventures
AmorChem
apo Asset Management GmbH
Aravis AG
Aurum Ventures MKI Ltd.
Bay City Capital
BB Biotech Ventures
Bergmann zur Hausen & Cie. GmbH
BioMedPartners AG
Boehringer Ingelheim Venture Fund
Breslin AG
Capricorn Venture Partners
CD-Venture GmbH
Cederberg GmbH
CFP BioConnect AG
Citi Group
Creathor Ventures
Cukierman & Co. Life Sciences
Deutsche Bank AG
Edison Investment Research
Edmond de Rothschild Investment Partners
Ernst & Young
European Investment Fund
Excellentia Gloabl Partners
F. Hoffmann-La Roche AG Roche Venture Fund
Forbion Capital Partners
Fraser Finance
Global Life Science Ventures
HBM Partners AG
HealthCap
High-Tech Gruenderfonds Management GmbH
IBB: Venture Capital Berlin
Imperial Innovations
Industrifonden
JSB Partners LP
Knoll Capital Management
Kreos Capital
Life Sciences Partners
Lundbeckford Ventures
LSP
Medical Strategy GmbH
MedVenture Partners GmbH
MRL Ventures, Merck & Co., Inc.
MS Ventures
Nextech Invest Ltd
NGN Captial
Novartis Venture Fund
Novo A/S
NRW Bank
Omega Funds
Oriel Securities Limited
Osprey Capital Partners Inc.
Percipient Capital
Pfizer Venture Investments
Piper Jaffray
Privateq Advisors AG
Remaco AG
RMI Partners
Rosetta Capital Limited
S.R.One, Limited
SBS Investments
Seroba Kernel Life Sciences Ltd.
Siemens Technology Accelerator GmbH
Silicon Valley Bank
Sofinnova Partners
Spinnovator – Ascenion GmbH
Takeda Ventures, Inc.
TEL Venture Capital, Inc
Teralys Capital
The Welcome Trust
Torreya Partners (Europe) LLC
TVM Capital
Ventac Partners
Vesalius Biocapital
VI Partners
Vinci Capital
Visium Asset UK LLP
Warwick Ventures Ltd
Wellington Partners
XOventure GmbH
Yorkville Advisors, LLC
Ysios Capital Partners

Pharma_BI-background0238

Announcement

LEADERS IN PHARMACEUTICAL BUSINESS INTELLIGENCE

will cover the event for the Scientific Media

Dr. Lev-Ari will be in attendance on 9/30 and 10/1/2014 at 

Congress Center Basel, Switzerland

by

SACHS Associates, London

http://www.sachsforum.com/basel14/Basel14-agenda.pdf

 

Basel2014

14th ANNUAL
BIOTECH IN EUROPE FORUM
For Global Partnering & Investment

30th September – 1st October 2014 • Congress Center Basel

SACHS Associates, London

http://www.sachsforum.com/basel14/basel14-agenda.html

With an exciting new location, Basel, and expanded programme, we would like to invite you to join The 14th Annual Biotech in Europe Forum for Global Partnering & Investment. The Forum is recognised as the leading international stage for those interested in investing & partnering with the biotech and life science industry in Europe. There are numerous networking opportunities including a reception in the city on the evening of 30th, online 1-2-1 meeting system with meeting facilities and exhibition.

WE WOULD ALSO LIKE TO HIGHLIGHT:

  • New Panels Added for 2014

– Drug Development and Manufacturing

– Pricing and Reimbursement.

Forum Agenda Now Online – click here to view

  • Financial, Advisory and Investors Attending include:

AbbVie Biotech Ventures, Inc. • Advent Life Sciences • Aescap Venture Management BV • Aglaia Biomedical Ventures B.V. • Amgen Ventures

To view full list – click HERE  

  • Attendees:

AbbVie • Abingworth LLP • Actelion Pharmaceuticals, Ltd • ActoGeniX NV • Advent Life Sciences

To view full list – click HERE  

  • Confirmed Presenting Companies:

Actogenix NV • AFreeze GmbH • AIDD • Akron Molecules AG • AM-Pharma • AnaptysBio, Inc. • Anergis SA • APEIRON Biologics AG • APEPTICO • Arisgen SA • Asceneuron SA • B-Cell Design • BioCrea • BiolineRx • Biomay • Canbex Therapeutics Ltd. • CAP-CMV GmbH • Dana Farber Cancer Institute • Epigenomics AG • F-star Biotechnology Ltd. • Heptares Therapeutics Limited • Idera • InnoMedica Holding AG • Isarna Therapeutics • Karus Therapeutics • Lanthio Pharma • Lorus Therapeutics • MaxCyte, Inc. • Minoryx Therapeutics s.l. • Mucosis B.V. • Mymetics S.A. • NBE-Therapeutics • Neovacs • Novogen Ltd • Numab AG • Oncos Therapeutics • Opexa • Oryzon • OticPharma Ltd. • PCI Biotech • Pharmaco-Kinesis Corporation • Piqur Therapeutics AG • Re-pharm • Russian Pharmaceutical Technologies • Scancell Limited • Scil Proteins • Spectrum Pharmaceuticals • Synthena AG • Synthon Biopharma • Ugichem • VBI Vaccines • and more TBA. 

FORUM PANELS WILL INCLUDE:

  • Public Markets and M&A
  • Future of Specialty Pharma
  • Investment
  • Partnering
  • Early Stage Investment
  • Scientific Collaborations
  • Pricing and Reimbursement
  • Drug Development and Manufacturing
  • Israel
  • Specific Therapeutic Panels:

– Autoimmune & Inflammatory

– CV & Metabolic Diseases

– Infectious Diseases

– Microbiome & Nutrition

– Neuroscience – Oncology

– Personalised Medicine & Diagnostics

– Platform Technologies & Novel Therapeutics

– Vaccines

Opportunities are available for you to join the event either as a delegate, presenter or exhibitor.

Please note we have limited presenting and exhibiting opportunities available.

♦ To enquire about Attending as a delegate click HERE.

♦ To enquire about Presenting click HERE.

♦ To enquire about Exhibiting click HERE.

We have reserved a number of complimentary places for accredited investors.

♦ To enquire about an accredited investor complimentary place click HERE

_______________________________

Please find information about special negotiated rates for events attendees at the local hotels at: https://hotel.basel.com/bpf2014/E 

Confirmed Speakers & Chairs include:

Keynote Speakers:

  • Anthony Rosenberg, Head of Global M&A and Licensing, Novartis Pharma AG
  • Iris Welten, CEO, Basel Area
  • Reinhard J. Ambros, Global Head, Novartis Venture Fund

Speakers:

  • Alain Huriez, Venture Partner, Advent Life Sciences
  • Andre Hoekema, Senior Vice President Corporate Development, Galapagos
  • Andrew Macpherson, Professor Immunology, University of Bern
  • Avi Spier, Director, Strategic Alliances, Novartis Institute for BioMedical Research, Inc.
  • Barbara Dalton, VP Venture Capital, Pfizer Inc.
  • Bernard Coulie, CEO, ActoGeniX NV
  • Bernard Sixt, CEO, ImmunID
  • Bernd Goergen, Investment Director, High-Tech Gruenderfonds Management GmbH
  • Björn Odlander, Founding Partner, HealthCap
  • Carlos Buesa, CEO, ORYZON
  • Carole Nuechterlein, Head of Roche Venture Fund Basel, Roche Venture Fund
  • Chris Britten, Head, Business Development, Sanofi Pasteur MSD
  • Chris Maggos, Business Development, Alpine Institute for Drug Discovery
  • Christina Takke, Partner, Forbion Capital Partners
  • Christoph Pittius, VP, Head of Transactions, Business Development, Global Product and Portfolio Strategy, AstraZeneca
  • Corrine Savill, Head Business Development & Licensing, Novartis Pharma AG
  • Daniel Dornbusch, Chief Commercial Officer, Nodality, Inc.
  • Dan J. Gelvin, Managing Director, Life Sciences, Aurum Ventures MKI Ltd.
  • David Alderson, EU Practice Lead, Global Market Access Consulting, Evidera
  • David Colpman, Head of Global Business Development, Shire
  • Deborah Harland, General Partner, SR One
  • Dirk Beher, CEO, ASCENEURON SA
  • Prof. Edwin Constable, Head of Research, University of Basel
  • Erik van den Berg, CEO, AM-Pharma B.V.
  • Esteban Pombo-Villar, Chief Operating Officer, Oxford BioTherapeutics AG
  • Dr Fintan Walton, Founder and CEO, PharmaVentures
  • Florian Schödel, Owner, Philimmune, LLC
  • Dr Frank Grams, VP, Head R&D Alliance Management & Contracting, Sanofi
  • Frank Kalkbrenner, Vice President, Head of the Boehringer Ingelheim Venture Fund, Boehringer Ingelheim GmbH
  • Genghis Lloyd-Harris, Partner, Abingworth LLP

To view the full list of speakers please click HERE  

Presenting Opportunities

Presenting at the forum offers excellent opportunities to showcase your company to some of the leading global investors and corporates. It will offer you the opportunity to communicate your projected capital raising plans or simply help you in finding the right partner for your business.

Sponsorship and Exhibition

Sachs Associates has developed an extensive knowledge of the key individuals operating within the European and global biotech industry. This together with a growing reputation for excellence puts Sachs Associates at the forefront of the industry and provides a powerful tool by which to increase the position of your company in this market. Raise your company’s profile directly with your potential clients. All of our sponsorship packages and exhibition packages are tailor made to each client, allowing your organisation to gain the most out of attending our industry driven events.

To learn more about presenting, exhibition or sponsorship opportunities, please click the links at the top of the email or contact Mina Orda + 44 (0)203 463 4890

or by email: Mina Orda.

Warm Regards The Sachs Associates Team 27 Belsize Lane, London NW3 5AS Tel: +44 (0)203 463 4890 • Fax: +44 (0)207 691 7919 • www.SachsForum.com

To UNSUBSCRIBE click HERE

Follow us on Twitter @SachsAssociates   Sponsored and supported by:

SOURCE

From: Ann Harris <ann@sachsforum.com>
Reply-To: <ann@sachsforum.com>
Date: Tue, 17 Jun 2014 15:08:59 +0100
To: <avivalev-ari@alum.berkeley.edu>
Subject: Agenda Now Online for the 14th Annual Biotech in Europe Investor Forum

About the 14th Annual Biotech in Europe Forum

The forum is recognised as the leading international stage for those interested in investing and partnering in the biotech and life science industry and is highly transactional. The Forum draws together an exciting cross-section of early-stage/pre-IPO, late-stage and public companies with leading investors, analysts, money managers and pharma licensing executives. Supported and designed by leading figures within Europe’s pharmaceutical and biotech industry, this event will once again be covered by our regular media partners. We expect over 600 delegates and 100 presenting companies.

The 14th Annual is held for the first time in Basel to be close to the largest biopharma hub in Europe and the Congress Center provides meeting space capable of handling several thousand one- to- one meetings as well as significant exhibition space. The Programme will feature twelve plenary panels/workshops covering BD & Licensing in the main therapeutic areas. There will be significant networking opportunities at the Forum and receptions.

Forum Panels will include:

  • Public Markets and M&A
  • Investment
  • Partnering
  • Early Stage Investment
  • Regional Clusters
  • Future of Specialty Pharma in Europe
  • Israel
  • Scientific Collaborations
  • Pricing and Reimbursement
  • Drug Discovery and Development
  • Specific Therapeutic Panels:
    • Autoimmune & Inflammatory
    • CV & Metabolic Diseases
    • Microbiome & Nutrition
    • Infectious Diseases
    • Neuroscience
    • Oncology
    • Personalised Medicine & Diagnostics
    • Platform Technologies & Novel Therapeutics
    • Vaccines

Confirmed Speakers include:

Keynote Speakers:

  • Anthony RosenbergHead of Global M&A and LicensingNovartis Pharma AG
  • Iris WeltenCEOBasel Area
  • Reinhard J. AmbrosGlobal HeadNovartis Venture Fund

Speakers:

  • Alain HuriezVenture PartnerAdvent Life Sciences
  • Andre HoekemaSenior Vice President Corporate DevelopmentGalapagos
  • Andrew MacphersonProfessor ImmunologyUniversity of Bern
  • Avi SpierDirector, Strategic AlliancesNovartis Institute for BioMedical Research, Inc.
  • Barbara DaltonVP Venture CapitalPfizer Inc.
  • Bernard CoulieCEOActoGeniX NV
  • Bernard SixtCEOImmunID
  • Bernd GoergenInvestment DirectorHigh-Tech Gruenderfonds Management GmbH
  • Björn OdlanderFounding PartnerHealthCap
  • Carlos BuesaCEOORYZON
  • Carole NuechterleinHead of Roche Venture Fund BaselRoche Venture Fund
  • Chris BrittenHead, Business Development, Sanofi Pasteur MSD
  • Chris MaggosBusiness Development, Alpine Institute for Drug Discovery
  • Christina TakkePartner, Forbion Capital Partners
  • Christoph PittiusVP, Head of Transactions, Business Development, Global Product and Portfolio Strategy, AstraZeneca
  • Corrine SavillHead Business Development & Licensing, Novartis Pharma AG
  • Daniel DornbuschChief Commercial OfficerNodality, Inc.
  • David ColpmanHead of Global Business DevelopmentShire
  • Deborah HarlandGeneral PartnerSR One
  • Dirk BeherCEOASCENEURON SA
  • Prof. Edwin ConstableHead of ResearchUniversity of Basel
  • Erik van den BergCEOAM-Pharma B.V.
  • Esteban Pombo-VillarChief Operating OfficerOxford BioTherapeutics AG
  • Dr Fintan WaltonFounder and CEOPharmaVentures
  • Dr Frank GramsVP, Head R&D Alliance Management & ContractingSanofi
  • Frank KalkbrennerVice President, Head of the Boehringer Ingelheim Venture Fund,
    Boehringer Ingelheim GmbH
  • Genghis Lloyd-HarrisPartnerAbingworth LLP
  • Graeme MartinPresident and CEO, Takeda Research Investment
  • Graham KellyChief Executive Officer, Novogen Ltd
  • Graziano SeghezziPartner, Sofinnova Partners
  • Guillaume VignonDirector Business Development Oncology – Global Business Development and LicensingEMD Serono
  • Hakan GokerInvestment DirectorMS Ventures
  • Hamza SuriaPresident & CEOAnaptysBio, Inc.
  • Jane DancerChief Business OfficerF-star Biotechnology Ltd.
  • Janet HammondVice President, Translational Medicine – Virology in Pharmaceutical Research and Early Development (pRED)F.Hoffmann La Roche AG
  • Janis NaeveManaging DirectorAmgen Ventures
  • Jason ColomaGlobal Head Venture & Innovation at Roche Partnering,
    F.Hoffmann La Roche AG
  • Jeff BaxterCEOVBI Vaccines
  • Jesse SchulmanCEOCanbex Therapeutics Ltd.
  • Johan VerbeeckSenior Director of Partnership Management, Johnson & Johnson Innovation CenterJanssen Pharmaceutical Companies of Johnson & Johnson
  • Johannes F. ZanzingerGlobal Head, CardioMetabolic Business Development and Licensing,Boehringer Ingelheim Pharma GmbH & Co. KG
  • John GustofsonSenior Director, Venture and Early Stage ColaborationAbbVie
  • Kai BrüningSenior Portfolio Managerapo Asset Management GmbH
  • Katya SmirnyaginaPartnerCapricorn Venture Partners
  • Laurent ChoppeManaging PartnerCukierman & Co. Life Sciences
  • Laurenz KellenbergerCSOBasilea
  • Lorenza CastellonBusiness Development ConsultantSuda Ltd.
  • Lothar SteidlerVice President TechnologyActoGeniX
  • Lubor GaalHead of Europe, Strategic Transactions GroupBMS
  • Luca BolligerVP and Group Licensing DirectorRECORDATI S.A.
  • Madhusudan V. PeshwaExecutive Vice President, Cellular TherapeuticsMaxCyte, Inc.
  • Maina BhamanDirector, Healthcare VenturesImperial Innovations
  • Malcolm WeirCo-Founder and Chief Executive OfficerHeptares Therapeutics
  • Markus EwertEVP Business DevelopmentGE Healthcare
  • Matthieu CoutetManaging PartnerInserm Transfert Initiative
  • Michael J. HanewichManaging Director, Healthcare and Life Science Venture Capital,
    Silicon Valley Bank
  • Michael ShalmiSenior PartnerNovo A/S
  • N. Roa MovvaNovartis Distinguished Scientist, Executive Director,
    DMP/NIBR/Novartis Pharma AG
  • Nicholas FrancoExecutive Vice President & Chief Business Development Officer,
    Actelion Pharmaceuticals, Ltd
  • O. Prem DasChief Research Business Development Officer and Heads DFCI’s Office of Research and Technology Ventures (ORTV)Dana-Farber Cancer Institute (DFCI)
  • Oliver MiddendorpCo-CEO & CBONumab AG
  • Peter BurckhardtChief Executive OfficerEVA – the Basel life sciences start-up agency
  • Philip A. SerlinChief Financial and Operating OfficerBioLineRx, Ltd.
  • Philippe CalaisCEOIsarna Therapeutics GmbH
  • Philippe Lopes-FernandesSenior Vice-President, Head of Global Licensing & Business DevelopmentMERCK KGaA / EMD
  • Pierre VandepapeliereCMONeovacs
  • Rainer HenningCEOBiomay AG
  • Rainer MetzgerVP Global Business Development PharmaQIAGEN GmbH
  • Rainer StrohmengerGeneral PartnerWellington Partners
  • Reid J. LeonardManaging DirectorMRL Ventures, Merck & Co., Inc.
  • Richard GoodfellowCEOScancell Holdings plc
  • Robin DavisonDirector, HealthcareEdison Investment Research
  • Søren MøllerManaging Investment DirectorNovo Seeds
  • Stefan FringsGlobal Head, Oncology Immunology Therapeutic AreaRoche
  • Stephanie LéouzonPrincipal and Head of Torreya Partners EuropeTorreya Partners
  • Stewart KayDirector Transactions, Worldwide Business DevelopmentGSK
  • Susan HillDirector of Global Business DevelopmentAlexion Pharma International Sarl
  • Thomas StockmanDirector, Healthcare Investment BankingCiti Group
  • Tim HerpinVice President, Head of Transactions (UK), Business DevelopmentAstraZeneca
  • Tim KnotnerusDirector Business DevelopmentAm-Pharma
  • Tom JohnstonCEOMucosis B.V.
  • Tom KronbachCEOBioCrea
  • Tomas LandhDirector, Strategy and Innovation SourcingNovo Nordisk
  • Ulf GrawunderCEONBE-Therapeutics Ltd
  • Vincent CharlonCEOAnergis SA
  • Vladimir CmiljanovicCEOPIQUR Therapeutics AG
  • Wilder FulfordPrincipalTorreya Partners (Europe) LLC
  • And More TBA…

Presenting Opportunities

Presenting at the forum offers excellent opportunities to showcase your company to some of the leading global investors and corporates. It will offer you the opportunity to communicate your projected capital raising plans or simply help you in finding the right partner for your business.

Presenting companies from Europe and the US will benefit from specially designed panels and keynote addresses from leading industry figures as well as access to some of the leading analysts and investors from Europe and beyond. This year, we aim to expand the audience and provide once again, opportunities for executive-level networking, deal-making and strategic partnering.

The forum is recognised as the leading international stage for those interested in investing in the biotech and life science industry and is highly transactional, drawing together an exciting cross-section of early-stage/pre-IPO, late-stage and public companies with leading investors, analysts, money managers and pharmas. Supported and designed by leading figures within Europe’s bio industry, this event will once again be covered by our regular media partners.

Sponsorship

Sachs Associates has developed an extensive knowledge of the key individuals operating within the European and global biotech industry. This together with a growing reputation for excellence puts Sachs Associates at the forefront of the industry and provides a powerful tool by which to increase the position of your company in this market.

Raise your company’s profile directly with your potential clients. All of our sponsorship packages are tailor made to each client, allowing your organisation to gain the most out of attending our industry driven events.

To learn more about presenting, exhibition or sponsorship opportunities, please contact
Mina Orda + 44 (0)203 463 4890 or by email: Mina Orda.

 

SOURCE

http://www.sachsforum.com/basel14/index.html

Editorials of event coverage via our Open Access Scientific Journal

http://pharmaceuticalintelligence.com

Scientific Journal Site Statistics

Date |Views to Date |# of articles |NIH Clicks |Nature Clicks

07/29/2013   217,356 1,138 1,389 705
12/01/2013   287,645 1,428 1,676 828
02/09/2014   325,039 1,665 1,793 892
03/05/2014   338,958 1,717 1,830 965
03/21/2014   347,667 1,750 1,838 974

03/31/2014  352,683 1,768 1,869 991

05/12/2014  373.696  1,878  1,944  1,035

06/18/2014  393,111  1,992  1,982  1,087

7/27/2014  418,570  2,098  2.050  1,124

9/2/2014  444,222  2,226  2,104  1,170

09/02/2014  

444.222 Views  

2,226 Articles  

NATURE clicks 1,170

ncbi.nlm.nih.gov clicks  2,104

fda.gov  clicks 198

cancer.gov  clicks  162

 

Pre e-Pub e-Books Flyers

 

Series C: e-Books on Cancer & Oncology

Volume One: Cancer Biology and Genomics for Disease Diagnosis

http://pharmaceuticalintelligence.com/biomed-e-books/series-c-e-books-on-cancer-oncology/cancer-biology-and-genomics-for-disease-diagnosis/

Volume Two: Therapies in Cancer – Surgery, Radiation, Chemo and Immunotherapies

http://pharmaceuticalintelligence.com/biomed-e-books/series-c-e-books-on-cancer-oncology/volume-2-immunotherapy-in-oncology/

Series B: Frontiers in Genomics Research

Volume One: Genomics Orientations for Individualized Medicine

http://pharmaceuticalintelligence.com/biomed-e-books/genomics-orientations-for-personalized-medicine/volume-one-genomics-orientations-for-personalized-medicine/

GENOMICS related articles in the JOURNAL

  • Cardiovascular Pharmacogenomics – 134 articles
  • Genomic Endocrinology, Preimplantation Genetic Diagnosis and Reproductive Genomics – 55 articles
  • Nutrigenomics – 43 articles
  • Pharmacogenomics – 88 articles
  • Genomic Testing: Methodology for Diagnosis – 241 articles
  • Personalized Medicine & Genomic Research – 390 articles
  • Genome Biology – 421 articles

Genomics Orientations for Individualized Medicine

Volume One

genomicsebook31

Read Full Post »

Exploring the Impact of Content Curation on Business Goals in 2013

Reporter: Aviva Lev-Ari, PhD, RN

 

Full Account:

http://stuff.scoop.it/nl/upload/pdf/Impact_of_Content_Curation_on_Business_Goals_in_2013.pdf

 

www.scoop.it

 

Exploring the impact of content curation on business goals in 2013

Content curation seems to have been one of the biggest marketing buzzwords of 2013. Hundreds of experts are telling businesses both small and large that content curation is the secret to success in content marketing and it’s time to get

Almost an entire quarter into 2014, it’s time to take “getting started” to the next level. Scoop.it surveyed professionals who have been using content curation as a part of their marketing strategy for the past year in order to discover its impact on business goals.

It just works

Scoop.it surveyed 1,550 professionals between October of 2013 and January of 2014 in order to gain a better understanding of their most important business goals as well as the challenges that these professionals are facing in accomplishing these

It’s been established many times that modern day professionals struggle to find the time to create original content, maintain their online presences, and keep track of the ever-increasing amount of information available on various topics. When taken a step further though, the findings demonstrate that more than half of professionals find solutions to these and other pain points through the use of content curation.

Many reports have emphasized the perceived importance of content curation, but for the first time ever, we’ve got quantitative proof that it works.

Overall, the findings demonstrate measurable business results as a result of content curation, and an even higher perceived value of curation for the upcoming business year.

 

What does it all mean?

The industry has reached a point in time where professionals no longer have to guess about the impact that content curation will have on reaching business goals and solving the issues faced by a vast majority of content marketers.

There is strong evidence in support of the business benefits of adding content curation to the content marketing mix. This report has taken the guesswork out of evaluating curation as a potential tool for accomplishing common goals like building engaged audiences, brand awareness, SEO, thought leadership and educating audiences by organizing large amounts of relevant content in a meaningful way.

93% of digital professionals surveyed plan on seeing a measurable impact from content curation in the upcoming year simply based upon the successes they saw during their first year using it.

 

Take the next step

There are endless resources available for professionals to begin learning about content curation, and it still isn’t too late to launch a curation-based strategy for 2014.

Begin feeding your content marketing needs today for better results tomorrow. Say bye to the buzzword and find out how Scoop.it can help you get the ball rolling.

SOURCE

From: “<Ally Greer>” , “Scoop.it” <contact@scoop.it>
Reply-To: “<Ally Greer>” , “Scoop.it” <contact@scoop.it>
Date: Tue, 25 Mar 2014 19:53:21 +0000
To: <avivalev-ari@alum.berkeley.edu>
Subject: FREE REPORT: Impact of curation on business goals

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See on Scoop.itCardiotoxicity

Shared with Dropbox (RT @MoveTheMedian: Health pros often need to help clients with medication compliance. health coaches can help.

See on www.dropbox.com

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See on Scoop.itCardiotoxicity

Family Medicine – Focus on…Medical Article: Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults (Antihypertensive medications and serious fall injuries in a nationally representative sample…

See on www.mdlinx.com

Read Full Post »

See on Scoop.itCardiovascular and vascular imaging

El Aidi H, Adams A, Moons KG, Den Ruijter HM, Mali WP, Doevendans PA, Nagel E, Schalla S, Bots ML, Leiner T.
J Am Coll Cardiol. 2014; 63(11):1031-1045.

See on www.thepreparedminds.com

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Technology: With a unique program, the US government has managed to drive the cost of genome sequencing down to $1,000

Reporter: Aviva Lev-Ari, PhD, RN

 

See on Scoop.itCardiovascular and vascular imaging

With a unique program, the US government has managed to drive the cost of genome sequencing down towards a much-anticipated target.

 

The quest to sequence the first human genome was a massive undertaking. Between 1990 and the publication of a working draft in 2001, more than 200 scientists joined forces in a $3-billion effort to read the roughly 3 billion bases of DNA that comprise our genetic material (International Human Genome Sequencing Consortium Nature 409, 860–921; 2001).

 

It was a grand but sobering success. The project’s advocates had said that it would reveal ‘life’s instruction book’, but in fact it did not make it possible to interpret how the instructions encoded in DNA were transformed into biology. Understanding how DNA actually influences health and disease would require studying examples of the links between genes and biology in thousands, perhaps millions, more people. The dominant technology at the time was Sanger sequencing, an inherently slow, labour-intensive process that works by making copies of the DNA to be sequenced that include chemically modified and fluorescently tagged versions of the molecule’s building blocks. One company, Applied Biosystems in Foster City, California, provided the vast majority of the sequencers to a limited number of customers — generally, large government-funded laboratories — and there was little incentive for it to reinvent its core technology.

 

A $7-million award from the NHGRI allowed the company to commercialize a technology called pyrosequencing, which was the first to begin chipping away at Applied Biosystems’ monopoly. The funding commitments also ultimately helped to convince private investors to enter the market. Stephen Turner, founder and chief technology officer of Pacific Biosciences in Menlo Park, California, says that his company’s 2005 NHGRI grant of $6.6 million helped to attract subsequent venture-capital funding.

 

The government program has invested $88 million in technologies based on nanopores and nanogaps. The form of this technology closest to the market involves reading bases as they are threaded through a pore (see Nature 456, 23–25; 2008), a method that has long promised to save costs and time by reading DNA while it is processed. It would negate the need for expensive and slow reactions to make lots of copies of the molecule. But solving basic issues, including how to move the DNA through the pore slowly enough, has been a major challenge. The NHGRI has funded work to overcome these hurdles — including $9.3 million given to collaborators of the company now ushering the concept to market, UK-based Oxford Nanopore Technologies (Nature http://doi.org/rvm; 2014).

 

Sequencing still needs much improvement, especially in terms of quality. For all of Sanger sequencing’s high cost, it remains the benchmark for accuracy. And sequencing costs are no longer dropping as quickly as they were a few years ago.

 

But researchers are optimistic that another technology will emerge to challenge Illumina. Most think, in fact, that the crucial questions for the field will shift away from technology. Now that sequencing is cheap enough to talk about scanning every patient’s genome, or at least the protein-coding portion of it, it is still not clear how that information will translate into improved care (Nature http://doi.org/rvq; 2014). These more complex issues will require another great leap in genomic science — one that could make the trouncing of Moore’s law seem easy

 

See on www.nature.com

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See on Scoop.itCardiovascular and vascular imaging

Studies have demonstrated that mesenchymal stromal cells (MSCs) could reverse acute and chronic kidney injury by a paracrine or endocrine mechanism, and microvesicles (MVs) have been regarded as a crucial means of intercellular communication.

See on stemcellres.com

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Natural Drug Target Discovery and Translational Medicine in Human Microbiome

Author and Curator: Demet Sag, PhD

 

Remember Ecology 101, simple description of ecosystem includes both living, biotic, and non-living, abiotic, that response to differentiation based on external and internal factors.  Hence, biodiversity changes since living systems are open systems and always try to reach stability. Both soil and human body are rich in microbial life against ever changing conditions. Previously, discovery of marine microorganisms for treatment of complex diseases especially cancer and drug discovery for pharmaceutical applications was discussed. (http://pharmaceuticalintelligence.com/2014/03/20/without-the-past-no-future-but-learn-and-move-genomics-of-microorganisms-to-translational-medicine/)

Here, the focus will be given to clinical drug discovery based on how lactose intolerance and human microbiome related to treat cancer patients or other diseases. In sum, creating clinical relevance with human microbiome require knowledge of both of the worlds to make best of it to solve complex diseases naturally.

The huge undertake as a roadmap to biomedical research originated by NIH under The Human Microbiome Project (HMP) (http://nihroadmap.nih.gov) with 250 healthy individuals as a starting point.  Recent developments opened the doors to pursue us to understand how human microbiome reflects on metabolism, drug interactions and numerous diseases.  Finally, association between clinical states and microbiome are improving with advanced algorithms, bioinformatics and genomics. In classical reading tests questions finding the simile between two groups of words can well relate how microbiome- human and soil-earth relates.  Both are rich in microbial life with quite changing characters to survive through commensal living.

Thus, it is also good to talk about how we can synthesize existing info on interactions between soil microorganisms and decomposers for human diseases and human microbiome. Epidemiology of living organisms is diverse but they all share common interest. In soil, for example, radioactively contaminated soil can’t support plant growth well so Nitrosomonas may support to bring the life to soil through supplying nitrogen. And others can be added to bring a favorable enriched soil.

In human microbiome nutrition-diseases interacts in such a harmony with genetic make up (the information received at time of birth germline- or acquired later in life due to mutations by various reasons). For example, the simplest example is lactose intolerance and the other is development of diabetes.  Generally, it is described as If person is missing a gene to metabolize lactose (sugar) this person become Lactose intolerant yet this can be gained before birth or after. The fix is easy since avoiding certain food groups i.e. milk products.

Yet, this is not that simple!

In human microbiome, the rich gastrointestinal (GI) tract contains many organisms and one of the most important ones is Enterococci that are often simply described as lactic-acid–producing bacteria—by under- appreciation of their power of microbial physiology and outcomes as well as their ubiquitous nature of enterococci.  Schleifer & Kilpper-Bälz, 1984 also reported that the Group D streptococci, such as Streptococcus faecalis and Streptococcus faecium, were included in the new genus called Enterococcus.

The importance of this genius, consists of 37 species, coming from their spectrum of  habitats that include the gastrointestinal microbiota of nearly every animal phylum and flexibility with ability to widely colonize, intrinsic resistance to many inhabitable conditions even though they don’t have spores but they can survive against desiccation and can persist for months on dried surfaces.  Furthermore, they can tolerate extreme conditions such as pH changes, ionizing radiation, osmotic and oxidative stresses, high heavy metal concentrations, and antibiotics.

There is a double sword application as these organisms used as probiotics to improve immune system of the host.  If it is human to prevent contaminated food related diseases or in animals prevent transmitting them to the consumers. Thus, E. faecium and E. faecalis strains are used as probiotics and are ingested in high numbers, generally in the form of pharmaceutical preparations to treat diarrhea, antibiotic-associated diarrhea or irritable bowel syndrome, to lower cholesterol levels or to improve host immunity.

When it comes to human body within each system specific organs may create distinct values.  For example the pH values of GI tract vary and during diseases since pH levels are not at at correct levels.  As a result, due to mal-absorption of nutrients and elements such as food, vitamins and minerals body can’t heal itself. This changing microbial genomics on the surface of GI reflects on general health.  Entrococcus family among the other GI’s natural flora has the microbial physiology adopt these various pH conditions well. 

 

Our body has its own standards to function, such as  pH, temperature, oxygen etc these are basics so that enzymatic reactions may happen to metabolize,synthesizing (making) or catalyzing (breaking) what we eat.  The pH is the measure of hydrogen-ion concentration  in solution.  For example, human blood has a narrow pH (7.35 – 7.45 ) and below or above this range means symptoms and disease yet if blood pH moves to much below 6.8 or above 7.8, cells stop functioning and the patient dies since the ideal pH for blood is 7.4.  This value is unified.  On the other hand, the pH in the human digestive tract or GI changes tremendously to adopt and carry on its function, the pH of saliva (6.5 – 7.5), upper portion of the stomach (4.0 – 6.5) where “predigestion” occurs, the lower portion of the stomach is secreting hydrochloric acid (HCI) and pepsin until it reaches a pH between 1.5 – 4.0; duodenum, small intestine, (7.0 – 8.5) where 90% of the absorption of nutrients is taken in by the body while the waste products are passed out through the colon (pH 4.0 – 7.0).

 

Why is pH important and how related to anything?

Development and presence of cancer always require an acid pH and lack of oxygen.  Thus, prevention of these two factors may be the key for treatment of cancer as it progress the acidity increases such that the level raises even up to 1000 more than normal levels.

Mainly, due to Warburg effect body opt to get its energy from fermentation of glucose and produce lactic acid that decreases the body pH from 7.3 down to 7 then to 6.5 in advanced stages of cancer.  Furthermore, during metastases this level even reaches to 6.0 and even 5.7 where body can’t fight back with the disease. (Warburg effect is well explained previously by Dr. Larry Berstein (www.linkedin.com/pub/larry-bernstein/38/94b/3aa).

How to bypass the lack of oxygen naturally?

One of the many solution can be a natural solution. The nature made the hemoglobin carrying bacteria, Vitreoscilla hemoglobin (VHb), which is first described by Dale Webster in 1966. The gram negative and obligate aerobic bacterium, Vitreoscilla synthesizes elevated quantities of a homodimeric hemoglobin (VHb) under hypoxic growth conditions.   The main role is likely the binding of oxygen at low concentrations and its direct delivery to the terminal respiratory oxidase(s) such as cytochrome o.  Then, after 1986 with detailed description of the molecule other hemoglobins and flavohemoglobins were identified in a variety of microbes, indicating the widespread occurrence of Hb-like proteins.   Currently, it is the most studied bacterial hemoglobin with application potentials in biotechnology.

It is a plausible solution to integrate Vitroscilla and Enterobacter powers for cancer detection and treatment naturally with body’s own microbiome.

However, there are many microbial organisms and differ person to person based on gender, age, background, genetic make-up, food intake, habits, location etc.  The huge undertake as a roadmap to biomedical research originated by NIH under The Human Microbiome Project (HMP) (http://nihroadmap.nih.gov) with 250 healthy individuals as a starting point.

There were three goals in the agenda of The Human Microbiome Project (HMP) simply:

 1. Utilize advanced high throughput technology,

2. Identify any association between microbiome and disease/health stages,

3. Initiate scientific studies to collect more data.

In sum, creating clinical relevance with human microbiome require knowledge of both of the worlds to make best of it to solve complex diseases naturally.

Previously  Discussed:

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Reporter-Curator: Stephen J. Williams, Ph.D.
http://pharmaceuticalintelligence.com/2013/03/12/ampk-is-a-negative-regulator-of-the-warburg-effect-and-suppresses-tumor-growth-in-vivo/

Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?
Author: Larry H. Bernstein, MD, FCAP
http://pharmaceuticalintelligence.com/2012/10/17/is-the-warburg-effect-the-cause-or-the-effect-of-cancer-a-21st-century-view/

Otto Warburg, A Giant of Modern Cellular Biology
Reporter: Larry H Bernstein, MD, FCAP
http://pharmaceuticalintelligence.com/2012/11/02/otto-warburg-a-giant-of-modern-cellular-biology/

Targeting Mitochondrial-bound Hexokinase for Cancer Therapy
Author: Ziv Raviv, PhD
http://pharmaceuticalintelligence.com/2013/04/06/targeting-mito…cancer-therapy

Nitric Oxide has a ubiquitous role in the regulation of glycolysis -with a concomitant influence on mitochondrial function
Curator, Larry H. Bernstein, MD, FCAP
http://pharmaceuticalintelligence.com/2012/09/16/nitric-oxide-has-a-ubiquitous-role-in-the-regulation-of-glycolysis-with-a-concomitant-influence-on-mitochondrial-function/

Potential Drug Target: Glucolysis Regulation – Oxidative stress-responsive microRNA-320
Reporter: Aviva Lev-Ari, PhD, RN
http://pharmaceuticalintelligence.com/2012/07/25/potential-drug-target-glucolysis-regulation-oxidative-stress-responsive-microrna-320/

Differentiation Therapy – Epigenetics Tackles Solid Tumors
Author-Writer: Stephen J. Williams, Ph.D.
http://pharmaceuticalintelligence.com/2013/01/03/differentiation-therapy-epigenetics-tackles-solid-tumors/

Prostate Cancer Cells: Histone Deacetylase Inhibitors Induce Epithelial-to-Mesenchymal Transition
Reporter-Curator: Stephen J. Williams, Ph.D.
http://pharmaceuticalintelligence.com/2012/11/30/histone-deacetylase-inhibitors-induce-epithelial-to-mesenchymal-transition-in-prostate-cancer-cells/

Mitochondrial Damage and Repair under Oxidative Stress
Curator: Larry H Bernstein, MD, FCAP
http://pharmaceuticalintelligence.com/2012/10/28/mitochondrial-damage-and-repair-under-oxidative-stress/

Mitochondria: Origin from oxygen free environment, role in aerobic glycolysis, metabolic adaptation
Curator: Larry H Bernsatein, MD, FCAP
http://pharmaceuticalintelligence.com/2012/09/26/mitochondria-origin-from-oxygen-free-environment-role-in-aerobic-glycolysis-metabolic-adaptation/

Expanding the Genetic Alphabet and Linking the Genome to the Metabolome
Reporter& Curator: Larry Bernstein, MD, FCAP
http://pharmaceuticalintelligence.com/2012/09/24/expanding-the-genetic-alphabet-and-linking-the-genome-to-the-metabolome/

What can we expect of tumor therapeutic response?
Author: Larry H. Bernstein, MD, FCAP
http://pharmaceuticalintelligence.com/2012/12/05/what-can-we-expect-of-tumor-therapeutic-response/

A Second Look at the Transthyretin Nutrition Inflammatory Conundrum
Larry H. Bernstein, MD, FACP
http://pharmaceuticalintelligence.com/2012/12/03/a-second-look-at-the-transthyretin-nutrition-inflammatory-conundrum/

 

Further  Readings and References:

Palmer KL, van Schaik W, Willems RJL, Gilmore MS. “Enterococcal Genomics Enterococci: From Commensals to Leading Causes of Drug Resistant Infection.” 2014-.2014 Feb 8

Franz CM, Holzapfel WH, Stiles ME. Enterococci at the crossroads of food safety?

Int J Food Microbiol.” 1999 Mar 1; 47(1-2):1-24.

Franz CM, Huch M, Abriouel H, Holzapfel W, Gálvez A.Int J Food Microbiol. “Enterococci as probiotics and their implications in food safety.” 2011 Dec 2; 151(2):125-40. Epub 2011 Sep 8.

Kayser FH.”Safety aspects of enterococci from the medical point of view.” Int J Food Microbiol. 2003 Dec 1; 88(2-3):255-62.

Webster DA, Hackett DP (1966). “The purification and properties of cytochrome o fromVitreoscilla“. J Biol Chem 241 (14): 3308–3315

Stark BC, Dikshit KL, Pagilla KR (2011). “Recent advances in understanding the structure, function, and biotechnological usefulness of the hemoglobin from the bacterium Vitreoscilla“. Biotechnol Lett 33 (9): 1705–1714

Stark BC, Dikshit KL, Pagilla KR (2012). “The Biochemistry  of Vitreoscillahemoglobin“. Computational and Structural Biotechnology Journal 3 (4): e201210002.

Brenner K, You L, Arnold F. (2008). “Engineering microbial consortia: A new frontier in synthetic biology.” Trends in Biotechnology 26: 483489.

Dunbar J, White S, Forney L. (1997). “Genetic diversity through the looking glass: Effect of enrichment bias.Applied and Environmental Microbiology 63: 13261331.

Foster J. (2001). “Evolutionary computation Nature Reviews Genetics 2: 428436.

Dinsdale EA, et al. 2008. “Functional metagenomic profiling of nine biomes.” Nature452: 629632.

Gudelj I, Beardmore RE, Arkin SS, MacLean RC. (2007). “Constraints on microbial metabolism drive evolutionary diversification in homogeneous environments.” Journal of Evolutionary Biology 20: 1882–1889.

Haack SK, Garchow H, Klug MJ, Forney L. (1995). “Analysis of factors affecting the accuracy, reproducibility, and interpretation of microbial community carbon source utilization patterns.” Applied and Environmental Microbiology 61: 14581468.

Lozupone C, Knight R. (2007). “Global patterns in bacterial diversity.” Proceedings of the National Academy of Sciences 104: 1143611440.

Thurnheer T, Gmr R, Guggenheim B,  (2004). “Multiplex FISH analysis of a six-species bacterial biofilm. “Journal of Microbiological Methods 56: 3747.

VijayKumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S,Sitaraman S, Knight R, Ley RE, Gewirtz AT. (2010). “Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5.” Science 328: 228231

Williams HTP, Lenton TM. (2007). “Artificial selection of simulated microbial ecosystems.” Proceedings of the National Academy of Sciences 104: 89188923.

 

 

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REAL TIME Cancer Conference Coverage: A Novel Methodology for Authentic Reporting on Presentations and Discussions launched via Twitter.com @ The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum in Drug Development, 19th March 2014 • New York Academy of Sciences • USA

Author, Curator, Life Sciences Reporter: Aviva Lev-Ari, PhD, RN

Article ID #123: REAL TIME Cancer Conference Coverage: A Novel Methodology for Authentic Reporting on Presentations and Discussions launched via Twitter.com @ The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum in Drug Development, 19th March 2014 • New York Academy of Sciences • USA. Published on 3/21/2014

WordCloud Image Produced by Adam Tubman

This article is by the same Curator as the following published on 1/4/2014:

conceived: NEW Definition for Co-Curation in Medical Research

RELATED ARTICLES

Cancer Biology and Genomics for Disease Diagnosis, Volume One Pre-ePub Announcement

Volatile Organic Compounds (VOCs) as Biomarkers in Cancer Detection: • Alnion Ranked #1 in “Top 10 Israeli medical advances to watch in 2014”.

Investing and inventing: Is the Tango of Mars and Venus Still on

Curator’s Position Statement

The complexity of presentations in Scientific Conferences requires a different Reporting methodology than the idea summarization by Science Journalists.

A Novel Methodology was applied @ The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum Promoting Public & Private Sector Collaboration & Investment in Drug Development, 19th March 2014 • New York Academy of Sciences • USA

Launched a novel methodology for Authentic Reporting on Presentations and Discussions in my quest to achieve REAL TIME Cancer Conference Coverage of content and Q&A.

Of all Social Media modalities I used the following:

  • Primary: Tweeting key idea by EVERY SPEAKER
  • Secondary: Tweeting all Q&A and Discussions
  • FaceBook posting
  • LinkedIn posting
  • WordPress.com e-Publishing @ http://pharmaceuticalinteligence.com

Below I present ALL the Tweets and the Retweets for 3/19/2014

Public and Private Partnership @ The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum Promoting Public & Private Sector Collaboration & Investment in Drug Development, 19th March 2014 • New York Academy of Sciences • USA

March 19, 2014 by 2012pharmaceutical

March 19, 2014 5PM
Public & Private Partnerships
Co-Chaired by:
  • Louis J. DeGennaro, Interim President and CEO, Chief Mission Ocer, The Leukemia and Lymphoma Society
  • Beth Jacobs, Managing Partner, Excellentia Global Partners Featuring:
  • Darryl Mitteldorf, Executive Director, Global Prostate Cancer Alliance
  • Dov Hass, Associate, Morgan, Lewis & Bockius LLP
  • Kristina Khodova, Head of Oncology Projects, Biomed Cluster, Skolkovo Foundation
  • Louise M. Perkins, Chief Science Ocer, Melanoma Research Alliance
  • Peter L. Hoang, Managing Director, Oce of Innovations, Technology Based Ventures, The University of Texas MD Anderson Cancer Center
  • Steven Young, President & COO, Addario Lung Cancer Medical Institute
  • Walter M. Capone, President, Multiple Myeloma Research Foundation
Public & Private Partnership
  • Foundation are playing a new role: The enable Cancer Research, links to biopharma, Scientific staff, understanding of the commercial landscape
  • Universities: Public & Private

Question #1: Difficulties in working with small biotech companies Non-Profits are disease focus, Biotech have expectation to gain capital funding from the Non-Profits Non-Profit has access to Patients information and disease condition in the pre-approval period, Consortia: addresses access to Resources do not invest or fund pharma companies, they fund diagnostics lab, stem cell companies Foundations  have right to publish data, IP ownership is still unresolved an issue, Dana Farber can’t be encouraged to give away its IP but a Foundation can accelerate the process.

IP Licensing Academic institution as LICENSORS WHILE HAVING having bond obligation, Tax exempt status is exclusive, while the bond owner status is non-exclusive Appetite for Risk – Venture Capital vs Foundation

  • Louis J. DeGennaro, Interim President and CEO, Chief Mission Ocer, The Leukemia and Lymphoma Society – provides $60 millions a year for R&D – they do take significant Risk. Size of population of patients is not a factor, serving all is. No detection, No screening, Patients present with full blown disease
  • Darryl Mitteldorf, Executive Director, Global Prostate Cancer Alliance — Risk does not belong to this organization. Foundation funded research on the disparity between Black and White patients.
  • Louise M. Perkins, Chief Science Officer, Melanoma Research Alliance – UV cause, funding research for personalized. medicine. Foundation has educated FDA, Sequencing of melanoma larger that sequencing of the Genome
  • Steven Young, President & COO, Addario Lung Cancer Medical Institute 70% of Lung Cancer Patients were not Smokers

__________________

8:00 AM –

On the 40th Floor of 7 World Trade Center in NYC @  The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum Promoting Public & Private Sector Collaboration & Investment in Drug Development, 19th March 2014 • New York Academy of Sciences • USA

Follow me @pharma_BI and @AVIVA1950

  • Event Coverage
  • Cancer & Genomic – Volume One in LPBI’s BioMed e-Series C: Cancer
  • Alnion Venture Funding Prospecting & Negotiation

Aviva Lev-Ari, PhD, RN Founder and Director Leaders in Pharmaceutical Business Intelligence

Editor-in-Chief http://pharmaceuticalintelligence.com

 TWEET LOG for 3/19/2014

  1. TODAY follow my Tweets @pharma_BI coverage for The 2nd ANNUAL Sachs Cancer Bio Partnering &… http://fb.me/1dvGXjXQC 

  2. Checkpoint inhibitors: Portfolio of antigens for a small # Tumors. Adjuvant combinations Risks: immune disease vs Cancer

  3. Argos Therapeutics: Leader in immunotherapy for Advanced Kidney cancer, vaccine development effort

  4. Tumor blockade via immunotherapy: active therapy, autologos, T cells depleted by kidney and tumor removal, healthy kidney was protected

  5. Precursors of breast lesions, target antigen, vaccine for cancer MAY or not evolve into immune event in the future

  6. Immunotherapy in Cancer: Tolerance of Cancer, central (thymus) breast/ovarian vs peripheral by checkpoint: skin, lungs, kidney vs

  7. Florian Schodel, Philimmune, immunotherapy in Cancer Development: vaccine for Cancer for secondary prevention breast/ovarian cancer

  8. All Options on the table when financing, best package requires flexibility. Outcome, Output, Process originality do clinical trial, find what kills

  9. Partnering in Phase I is dangerous vs Stage IV, companion diagnostics, not enough money in the product to share.

  10. Future Trends in Oncology: preclinical going IPO, China for clinical trial at different standard of care than US or Europe

  11. Carole Nuechterlein, Head Roche Venture Fund: Big Pharma offers to biotech knowledge on combination drugs to select for development. Biotech tend to overestimate value of the assets

  12. Tim Herpin, Head Transactions (UK) BD AstraZeneca: Acquisition is preferred to partnership

  13. Stuart Barich, Oppenheimer & Co. Holding to assets vs. Partnering – HOLD as long as a biotech can

  14. Anne Altmeyer, VP Oncology, Novartis: Only 5% of all Cancer drugs move from Phase I to phase II – Oncology drugs 36% of all current cancer drugs are in Phase II

  15. Commercialization is only one factor in Transforming Patient life’s by drug response in clinical trials – repurposed drugs vs generic

  16. Regulatory affairs: 30% of applications are approved, most cancer indications requires orphan drug development – niche of patient

  17. Celgene partners with Foundation Medicine or Diagnostics development, Roche has own Diagnostics – small biotech vs big Pharma

  18. Guillaume Vignon, Dir BD, EMD Serono: Finding the right patient by selection for obtaining response – key for clinical study success & Translational Team

  19. Anne Altmeyer, VP Oncology Novartis: Strategies for Small Molecule and Biologicals Drug Development, 1/3 of top 100 drugs and 22% of drug approval are Biologicals this is the future

  20. Moffitt Total Cancer Care DB Solid Tumor signature – Cancer Vaccine, genotype—>>>>phenotype demographic histology over expression of genes

  21. M2GEN – Concortium with Community Hospitals: WORLD largest biorepository Moffitt/Merck/Community Hospital, Genomic Marker

  22. J. Mule, Moffitt Cancer Center: Translational Research for Personalized Medicine: M2GEN collaboration StateMerck/Moffitt 3rd largest in US

  23. BRAF inhibition: not enough patients for genetic mutation based clinical trial, BiomarkersDiagnostics in collaboration w/academia is optimal

  24. TODAY follow my Tweets @pharma_BI coverage for The 2nd ANNUAL Sachs Cancer Bio Partnering &… http://fb.me/1jxkUHMlJ 

  25. N.C. Dracopoli of Janssen R&D: Biomarkers for Diagnosis – Prognosis, Predicative test, pharmacodygnostic test FDA 32 genomics biomarkers approved

  26. Tx w/anti-IL-6 for ALL – Great Prognosis, Novartis and UPenn collaboration most promising big Pharma and Academia case

  27. Philip Gotwals, Oncology Novartis, Translational Research, collaboration with UPenn – Org clarity challenging

  28. TODAY follow my Tweets @pharma_BI coverage for The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum Promoti…http://lnkd.in/dbHd85U

  29. TODAY follow my Tweets @pharma_BI coverage for The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum… http://wp.me/p2kEDv-5AX 

  30. Cancer Biology and Genomics for Disease Diagnosis, Volume One Pre-ePub Announcement http://lnkd.in/d83gUrY 

  31. Power of Analogy: Curation in Music, Music Critique as a Curation and Curation of Medical Research Findings – A Comp…http://lnkd.in/dBbahTf 

  32. Aviva Lev-Ari ‏@AVIVA1950  Mar 19

 Re-TWEETS

1. @pharma_BI@Pharma_BI Mar 19

Future Trends in Oncology: preclinical gong IPO, China for clinical trial at different standard of care than US or Europe

  • Retweet 1: Gil Press
  • Favorite 1: Kimberly Ha
  • 8:23 AM – 19 Mar 2014 · Details

2. @pharma_BI@Pharma_BI Mar 19

Big Pharma offers to biotech knowledge on combination drugs to select for development. Biotech tend to overestimate value of the assets

  • Retweet 1: Gil Press

8:35 AM – 19 Mar 2014 · Details

3. @pharma_BI@Pharma_BI Mar 19

Only 5% of all Cancer drugs move from Phase I to phase II -Oncology drugs 36% of all current cancer drugs are in Phase II

7:51 AM – 19 Mar 2014 · Details

4. @pharma_BI@Pharma_BI Mar 19

Commercial only one factor in Transforming Patient life’s by drug response in clinical trials – repurposed drugs vs generic

  • Retweet 1 – Gil Press

5. @pharma_BI@Pharma_BI Mar 19

Celgene partners with Foundation Medicine or Diagnostics development, Roche has own Diagnostics – small biotech vs big Pharma

  • Retweet 1 – Gil Press

7:03 AM – 19 Mar 2014 · Details

6. @pharma_BI@Pharma_BI Mar 19

TODAY follow my Tweets @pharma_BI coverage for The 2nd ANNUAL Sachs Cancer Bio Partnering &… http://fb.me/1jxkUHMlJ 

  • Retweet 1 – Gil Press

6:16 AM – 19 Mar 2014 · Details

7.  @pharma_BI@Pharma_BI Mar 14

The 2nd ANNUAL Sachs Cancer Bio Partnering & Investment Forum Promoting Public & Private Sector Col… http://wp.me/p2kEDv-55i  via @Pharma_BI

Retweeted by @pharma_BI

8. Sachs Associates Ltd@SachsAssociates Dec 10

2nd Annual SachsCancerBioPartnering Forum, 19th March, New York. Info: http://goo.gl/GLD3Dg  Early Bird Registration:http://goo.gl/rX0RpW 

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 What is the key method to harness Inflammation to close the doors for many complex diseases?

 

Author and Curator: Larry H Bernstein, MD, FCAP

 

The main goal is to  have a quality of a healthy life.

When we look at the picture 90% of main fluid of life, blood, carried by cardiovascular system with two main pumping mechanisms, lung with gas exchange and systemic with complex scavenger actions, collection of waste, distribution of nutrition and clean gases etc.  Yet without lymphatic system body can’t make up the 100% fluid.  Therefore, 10% balance is completed by lymphatic system as a counter clockwise direction so that not only the fluid balance but also mass balance is  maintained. Finally, the immune system patches the  remaining mechanism by providing cellular support to protect the body because it contains 99% of white cells to fight against any kinds of invasion, attack, trauma.

These three musketeers, ccardiovascular, lyphatic and immune systems, create the core mechanism of survival during human life.

However, there is a cellular balance between immune and cardiovascular system since blood that made up off 99% red cells and 1% white blood cells that are used to scavenger hunt circulating foreign materials.   These three systems are acting with a harmony not only defend the body but provide basic needs of life.  Thus, controlling angiogenesis and working mechanisms in blood not only helps to develop new diagnostic tools but more importantly establishes long lasting treatments that can harness Immunomodulation.

The word inflammation comes from the Latin “inflammo”, meaning “I set alight, I ignite”.

Medical Dictionary description is:

“A fundamental pathologic process consisting of a dynamic complex of histologically apparent cytologic changes, cellular infiltration, and mediator release that occurs in the affected blood vessels and adjacent tissues in response to an injury or abnormal stimulation caused by a physical, chemical, or biologic agent, including the local reactions and resulting morphologic changes; the destruction or removal of the injurious material; and the responses that lead to repair and healing.”

The five elements makes up the signature of  inflammation:  rubor, redness; calor, heat (or warmth); tumor swelling; and dolor, pain; a fifth sign, functio laesa, inhibited or lost function.   However, these indications may not be present at once.

Please click on to the following link for genetic association of autoimmune diseases (Cho Et al selected major association signals in autoimmune diseases) from Cho JH, Gregersen PK. N Engl J Med 2011;365:1612-1623.

Inflammatory diseases grouped under two classification: the immune system related due to  inflammatory disorders, such as both allergic reactions  and some myopathies, with many immune system disorders.  The examples of inflammatory disorders  include Acne vulgaris, asthma, autoimmune disorders, celiac disease, chronic prostatitis, glomerulonepritis, hypersensitivities, inflammatory bowel diseases, pelvic inflammatory diseases, reperfusion diseases, rheumatoid arthritis, sarcoidosis, transplant rejection, vasculitis, interstitial cyctitis, The second kind of inflammation are related to  non-immune diseases such as cancer, atherosclerosis, and ischaemic heart disease.

This seems simple yet at molecular physiology and gene activation levels this is a complex response as an innate immune response from body.  There can be acute lasting few days after exposure to bacterial pathogens, injured tissues or chronic inflammation continuing few months to years after unresolved acute responses such as non-degradable pathogens, viral infection, antigens or any  foreignmaterials, or autoimmune responses.

As the system responses arise from plasma fluid, blood vessels, blood plasma through vasciular changes, differentiation in plasma cascade systems like coagulation system, fibrinolysis, complement system and kinin system.  Some of the various mediators include bradykinin produced by kinin system, C3, C5, membrane attack system (endothelial cell activation or endothelial coagulation activation mechanism) created by the complement system; factor XII that can activate kinin, fibrinolysys and coagulation systems at the same time produced in liver; plasmin from fibrinolysis system to inactivate factor Xii and C3 formation, and thrombin of coagulation system with a reaction through protein activated receptor 1 (PAR1), which is a seven spanning membrane protein-GPCR.   This system is quite fragile and well regulated.  For example activation of inactive Factor XII by collagen, platelets, trauma such as cut, wound, surgery that results in basement membrane changes since it usually circulate in inactive form in plasma automatically initiates and alerts kinin, fibrinolysis and coagulation systems.

Furthermore, the changes reflected through receptors and create gene activation by cellular mediators to establish system wide unified mechanisms. These factors (such as IFN-gamma, IL-1, IL-8, prostaglandins, leukotrene B4,  nitric oxide, histamines,TNFa) target immune cells and redesign their responses, mast cells, macrophages, granulocytes, leukocytes, B cells, T cells) platelets, some neuron cells and endothelial cells.  Therefore, immune system can react with non-specific or specific mechanisms either for a short or a long term.

As a result, controlling of mechanisms in blood and prevention of angiogenesis answer to cure/treat many diseases  Description of angiogenesis is simply formation of new blood vessels without using or changing pre-existing capillaries.  This involves serial numbers of events play a central role during physiologic and pathologic processes such as normal tissue growth, such as in embryonic development, wound healing, and the menstrual cycle.  However this system requires three main elements:  oxygen, nutrients and getting rid of waste or end products.

Genome Wide Gene Association Studies, Genomics and Metabolomics, on the other hand, development of new technologies for diagnostics and non-invasive technologies provided better targeting systems.

In this token recent genomewide association studies showed a clear view on a disease mechanism, or that suggest a new diagnostic or therapeutic approach particularly these disorders are related to  genes within the major histocompatibility complex (MHC) that predisposes the most significant genetic effect.  Presumably, these genes are reflecting the immunoregulatory effects of the HLA molecules themselves. As a result, the working mechanism of pathological conditions are revisited or created new assumptions to develop new targets for diagnosis and treatments.

Even though B and T cells are reactive to initiate responses there are several level of mechanisms control the cell differentiation for designing rules during health or diseases. These regulators are in check for both T and B cells.  For example, during Type 1 diabetes there are presence of more limited defects in selection against reactivity with self-antigens like insulin, thus, T cell differentiation is in jeopardy.  In addition, B cells have many active checkpoints to modulate the immune responses like  pre-B cells in the bone marrow are highly autoreactive yet they prefer to stay  in naïve-B cell forms in the periphery through tyrosine phosphatase nonreceptor type 22 (PTPN22) along with many genes play a role in autoimmunity.  In a nut shell this is just peeling the first layer of the onion at the level of Mendelian Genetics.

There is a great work to be done but if one can harness the blood and immune responses many complex diseases patients may have a big relief and have a quality of life.  When we look at the picture 90% of main fluid of life, blood, carried by cardiovascular system with two main pumping mechanisms, lung with gas exchange and systemic with complex scavenger actions, collection of waste, distribution of nutrition and clean gases.  Yet, without lymphatic system body can’t make up the 100% fluid.  Therefore, 10% balance is completed by lymphatic system as a counter clockwise direction so that not only the fluid balance but also mass balance is  maintained. Finally, the immune system patches the  remaining mechanism by providing cellular support to protect the body because it contains 99% of white cells to fight against any kinds of invasion, attack, trauma.

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