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Posted in Bio Instrumentation in Experimental Life Sciences Research, Biomarkers & Medical Diagnostics, BioSimilars, Cardiac & Vascular Repair Tools Subsegment, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, Disease Biology, Small Molecules in Development of Therapeutic Drugs, Ecosystems & Industrial Concentration in the Medical Device Sector, FDA Regulatory Affairs, Frontiers in Cardiology and Cardiovascular Disorders, Health Economics and Outcomes Research, HTN, Medical Devices R&D and Inventions, Medical Devices R&D Investment, Origins of Cardiovascular Disease, Pharmaceutical Industry Competitive Intelligence, Pharmaceutical R&D Investment, Pharmacotherapy of Cardiovascular Disease, Regulated Clinical Trials: Design, Methods, Components and IRB related issues | Tagged Cardiology, Cardiovascular disease, Columbia University Medical Center, Craig Smith, Eugene Braunwald, Implantable Synchronized Cardiac Assist Device, New England Journal of Medicine, Triple Antihypertensive Combination Therapy | 10 Comments

10 Responses

1. on April 27, 2013 at 1:12 AM | Reply Drug Eluting Stents: On MIT’s Edelman Lab’s Contributions to Vascular Biology and its Pioneering Research on DES | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
   Open Journals vs. Subscription-based « Pharmaceutical Intelligence”, very compelling plus the blog post ended up being a good read.
   Many thanks,Annette

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2. on May 4, 2013 at 1:24 PM | Reply Stents, biologically active implants and vascular repair | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
   Open Journals vs. Subscription-based « Pharmaceutical Intelligence”, very compelling plus the blog post ended up being a good read.
   Many thanks,Annette

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3. on May 5, 2013 at 5:54 PM | Reply Bioengineering of Vascular and Tissue Models | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
   Open Journals vs. Subscription-based « Pharmaceutical Intelligence”, very compelling plus the blog post ended up being a good read.
   Many thanks,Annette

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4. on May 31, 2013 at 3:45 PM | Reply Transposon-mediated Gene Therapy improves Pulmonary Hemodynamics and attenuates Right Ventricular Hypertrophy: eNOS gene therapy reduces Pulmonary vascular remodeling and Arterial wall hyperplasia | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
   Open Journals vs. Subscription-based « Pharmaceutical Intelligence”, very compelling plus the blog post ended up being a good read.
   Many thanks,Annette

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5. on June 17, 2013 at 11:43 AM | Reply Transcatheter Aortic Valve Replacement (TAVR): Postdilatation to Reduce Paravalvular Regurgitation During TAVR with a Balloon-expandable Valve | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
   Open Journals vs. Subscription-based « Pharmaceutical Intelligence”, very compelling plus the blog post ended up being a good read.
   Many thanks,Annette

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6. on June 17, 2013 at 11:46 AM | Reply On Devices and On Algorithms: Prediction of Arrhythmia after Cardiac Surgery and ECG Prediction of an Onset of Paroxysmal Atrial Fibrillation | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
   Open Journals vs. Subscription-based « Pharmaceutical Intelligence”, very compelling plus the blog post ended up being a good read.
   Many thanks,Annette

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7. on June 17, 2013 at 4:05 PM | Reply Trans-apical Transcatheter Aortic Valve Replacement in a Patient with Severe and Complex Left Main Arterial (LMA) Disease | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
   Open Journals vs. Subscription-based « Pharmaceutical Intelligence”, very compelling plus the blog post ended up being a good read.
   Many thanks,Annette

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8. on June 23, 2013 at 4:51 PM | Reply Comparison of cardiothoracic bypass and percutaneous interventional catheterization survivals | Pharmaceutical Intelligence

   I actually consider this amazing blog , “SAME SCIENTIFIC IMPACT: Scientific Publishing –
   Open Journals vs. Subscription-based « Pharmaceutical Intelligence”, very compelling plus the blog post ended up being a good read.
   Many thanks,Annette

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9. on January 26, 2014 at 4:14 PM | Reply Transcatheter Valve Competition in the United States: Medtronic CoreValve infringes on Edwards Lifesciences Corp. Transcatheter Device Patents | Pharmaceutical Intelligence

   This is very insightful. There is no doubt that there is the bias you refer to. 42 years ago, when I was postdocing in biochemistry/enzymology before completing my residency in pathology, I knew that there were very influential mambers of the faculty, who also had large programs, and attracted exceptional students. My mentor, it was said (although he was a great writer), could draft a project on toilet paper and call the NIH. It can’t be true, but it was a time in our history preceding a great explosion. It is bizarre for me to read now about eNOS and iNOS, and about CaMKII-á, â, ã, ä – isoenzymes. They were overlooked during the search for the genome, so intermediary metabolism took a back seat. But the work on protein conformation, and on the mechanism of action of enzymes and ligand and coenzyme was just out there, and became more important with the research on signaling pathways. The work on the mechanism of pyridine nucleotide isoenzymes preceded the work by Burton Sobel on the MB isoenzyme in heart. The Vietnam War cut into the funding, and it has actually declined linearly since.

   A few years later, I was an Associate Professor at a new Medical School and I submitted a proposal that was reviewed by the Chairman of Pharmacology, who was a former Director of NSF. He thought it was good enough. I was a pathologist and it went to a Biochemistry Review Committee. It was approved, but not funded. The verdict was that I would not be able to carry out the studies needed, and they would have approached it differently. A thousand young investigators are out there now with similar letters. I was told that the Department Chairmen have to build up their faculty. It’s harder now than then. So I filed for and received 3 patents based on my work at the suggestion of my brother-in-law. When I took it to Boehringer-Mannheim, they were actually clueless.

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10. on April 17, 2014 at 10:11 AM | Reply Cardiovascular Diseases and Pharmacological Therapy: Curations by Aviva Lev-Ari, PhD, RN | Pharmaceutical Intelligence

    This is very insightful. There is no doubt that there is the bias you refer to. 42 years ago, when I was postdocing in biochemistry/enzymology before completing my residency in pathology, I knew that there were very influential mambers of the faculty, who also had large programs, and attracted exceptional students. My mentor, it was said (although he was a great writer), could draft a project on toilet paper and call the NIH. It can’t be true, but it was a time in our history preceding a great explosion. It is bizarre for me to read now about eNOS and iNOS, and about CaMKII-á, â, ã, ä – isoenzymes. They were overlooked during the search for the genome, so intermediary metabolism took a back seat. But the work on protein conformation, and on the mechanism of action of enzymes and ligand and coenzyme was just out there, and became more important with the research on signaling pathways. The work on the mechanism of pyridine nucleotide isoenzymes preceded the work by Burton Sobel on the MB isoenzyme in heart. The Vietnam War cut into the funding, and it has actually declined linearly since.

    A few years later, I was an Associate Professor at a new Medical School and I submitted a proposal that was reviewed by the Chairman of Pharmacology, who was a former Director of NSF. He thought it was good enough. I was a pathologist and it went to a Biochemistry Review Committee. It was approved, but not funded. The verdict was that I would not be able to carry out the studies needed, and they would have approached it differently. A thousand young investigators are out there now with similar letters. I was told that the Department Chairmen have to build up their faculty. It’s harder now than then. So I filed for and received 3 patents based on my work at the suggestion of my brother-in-law. When I took it to Boehringer-Mannheim, they were actually clueless.

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