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Live 2:30-4:30 PM Mediterranean Diet and Lifestyle: A Symposium on Diet and Human Health: October 19, 2018

Posted in Acute coronary syndrome, Cancer - General, Cancer Prevention: Research & Programs, congestive heart failure, Epigenetics and Cardiovascular Risks, Heart Failure (HF), interventional oncology, Obesity, Scientific & Biotech Conferences: Press Coverage, Scientific Publishing, tagged application to nutrition, balanced life, dietician, healthy diet, healthy eating, lifestyle, mediteranean diet, Mediterranean Diet, New York University, Nutrition, phytochemicals, preventive healthcare, wellness on October 20, 2018| Leave a Comment »

Live 2:30-4:30 PM Mediterranean Diet and Lifestyle: A Symposium on Diet and Human Health: October 19, 2018

Reporter: Stephen J. Williams, Ph.D.

2:30 Mediterranean Diet, Intangible Heritage and Sustainable Tourism?

Prof. Fabio Parasecoli, PhD.

Nutrition and Food Department, New York University

We focus on more of the cultural aspects and the relevance of this diet to tourism in Italy where there is a high rate of unemployment. The diet is interesting from a touristic standpoint as the diet have the perspective of the different ingredients inherent in Italy. The mediterranean diet food pyramid totally different than US. How do we explain to consumers these medical concepts; for example in China, Germany they are using different ways to explain the benefits of this diet.

A Cultural Formation

a way of life, for tourism there is the way of life people want to adopt (easiest way to do this is go to the Mediterranean and learn the lifestyle)
so for example Olive Garden for marketing purposes sent a few chefs for half a day training so the image of learning to cook in the mediterranean diet style can be very powerful communicative tool
2003 UNESCO Convention for Safeguarding the Culturing Heritage: protecting landscapes but then decided to protect other intangible heritage like oral, language, oral traditions like transmitting recipes, social and festive events (how do we cook how do we grow tomatoes, wheat etc)
UNESCO: promoted France Gastronomic, Mediterranean Diet, and traditional Mexican Cuisine (Mayan)
defined Greece, Italy, Morroco then included Cyprus Crotia and Portugal in the Mediterranean diet
has it been used for promotion: no UNESCO did not use this since does not safeguard the culture
(gastrodiplomacy); like Korea and kimchie; included in the list of cultural cuisine but can create tourist bubbles as you tourism places like hotels don’t always use; for reasons of economy or safety or accessibility , local food
Centrality of Territorio: food consumed from tourist should come from the area

Sustainable Tourism: a form of tourism where have the intention to get to know the place;

have to think in three ways

environmental
social
cultural

how do we make a circular economy so no waste; for example certain companies using food waste to make other products

Tourism clusters made of many groups; he is working on a way to jump start these networks in Nigeria;

Sustainable Food Supply Chain Tourism can be used as way to engage people and promote the diet

Question: are there regions where people are not adopting the diet because of taste, preferences

Yes there is always a problem with accessibility, affordability, trade issues and regional acceptance. For instance in Australia a big push back against the Mediterranean diet. Medical professionals need to work with communication experts and media experts in developing ways to communicate the benefits since “no one wants to be preached at” and “as economies get richer people want to be more modern and try new things”

In Nigeria we are working with many different industries like transportation, engineers, the IT industry and chefs to build a scalable model

3.00 Italy as a Case Study: Increasing Students’ Level of Awareness of the Historical, Cultural, Political and Culinary Significance of Food

Prof. Lisa Sasson

Nutrition and Food Department, New York University

Started a program at NYU to understand food from a nutritionist and historical point of view as a cultural heritage in Italy, but when students came back students mentioned it changed their food shopping habits

they described diet as wine, pasta, and olive oil

Artisional Production: understanding the taste and flavor; she wanted them to learn about the food culture and educate their tastes

Food Memories: how we pass on recipes and food aromas, food tastes. The students were experienced food in a unique way for the first time, experiencing what cheese, quality oil other foods when fresh tastes like. Artisional foods may be expensive but need only a little of it because the tastes and flavors are so potent due to the phytochemicals

Within six months students:

increased consumption of weekly wine consumption with meals
increased consuming satisfying meals
increased time consuming meals

In the womb the fetus is actually acquiring sense of taste (amniotic fluid changes with mother diet; can detect flavor chemicals)

Student Perceptions after a study Abroad Program

eating foods local and seasonal
replacing butter with quality olive oil
using herbs
very little sugar
unsweetened beverages
limiting red meats
fish a couple of times a week
dairy in moderation
no processed foods

Eating and Dining for Americans is a Challenge: The students ate well and satisfying meals but ate alot but did not gain weight

3:30 Italian Migration and Global Diaspora

Dr. Vincenzo Milione, PhD

Director of Demographics Studies, Calandra Institute, City University of New York

for a PDF of this presentation please click here: sbarro handout.

Dr. Millione used the U.S. Census Bureau Data to estimate the growth of the Italian diaspora descendants in host countries in the Americas and to determine the mixed global ancestry of Italian descendants.

Italian emigration to the US happened in two waves

Wave 1: early 1900 peaking between 1901 and 1911 (turn of century)
Wave 2: 1951-1971 (post WWII)

This pattern was similar between North and South America although South American had first Italian immigration; in 1860 we got rid of slavery so many jobs not filled new orleans

Developing a mathematical model of Italian diaspora: the model is centered on the host country population dynamics but descendants are separated into first generation and multi generation

Model dependent on:

birth and death rates
first generation population growth
multi generational population growth
emigration from host country over time

He was able to calculate an indices he termed Year of Italianization Change (YIC): the year the growth of the multi generation supercedes the first generation immigrant population

Country	Year of Italianlization Change (YIC)
Brazil	1911
Uruguay	1915
Argentina	1918
USA	1936
Venezuela	1963
Canada	1968
Australia	1988

note: as a result there is an increasing loss of language and traditional customs with host country cultural adaptation among the native born descendants

In addition, over the last 20 years Italian-American population growth demonstrates that Italian-American self-identity in the United States has increased. The census data identified two ancestries of the respondent. In mixed ancestry Italian-American respondents to the extent they identify Italian first demonstrating the strong Italian-American identity.

The foreign born Italian Americans mirror the immigration pattern of Italian immigration from Italy until 1980 where more Italian Americans self identify as foreign born in other countries and not in Italy

Summary

over 5 million Italians have emigrated from Italy from 1980 to present
most went to North and South America but many went to other global countries
the Italian immigration to the different countries in the Americas varies over the period of mass emigration when the growth of multi generational Italian descendants is greater then first generation Italians (Year of Italianization Change) goes from 1911 in Brazil to 1988 in Australia
Immigrants to the USA was not just from Italy but from almost all nations globally over all geographical continents
Italina immigrants descendants greatly grew after 1930 with appreciable increase with other ethnicities such that 61% of Italian Americans are mixed ancestry in 2014: to date mixed ancestry represents 98% of Italian Americans
younger italian americans more likely to have mixed ancestry with Central and South America, Asian and African ethnicities

over time during immigration eating habits has changed but more research is needed if and how the italian recipes and diet has changed as well

4:15 Conclusions

Prof. Antonio Giordano, MD, PhD.

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Cancer drugs proving worth

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, tagged Chemotherapy, Clinical trial, Crizotinib, New York University, Pfizer, Reuters, Robert Schneider, Vemurafenib on March 2, 2013| Leave a Comment »

Cancer drugs proving worth

Reporter: Larry H. Bernstein, MD, FCAP

INSIGHT – Cancer drugs proving worth earlier in testing
By Bill Berkrot and Ransdell Pierson | Reuters – Mon, Feb 25, 20

http://ph.news.yahoo.com/insight-cancer-drugs-proving-worth-earlier-testing-060402726–finance.html?goback=%2Egde_72923_member_217729560/

NEW YORK (Reuters) – Michael Weitz was out of options. The Californian had endured chemotherapy, radiation and surgery but his lung cancer still spread to his bones and brain. He was entered into a Phase I study – the earliest stage of human testing for a new medicine – of crizotinib. The drug works for about 4 percent of advanced lung cancer patients with a mutated form of a protein called ALK.

Weitz, now 55, is cancer-free after three years of taking the drug now sold by Pfizer as Xalkori after an unusually swift development process.

It typically has taken a decade and $1 billion to bring a new treatment to market. But in the last two years a handful of cancer drugs – including Onyx Pharmaceutical Inc’s Kyprolis for multiple myeloma, Roche’s Zelboraf for melanoma, and Pfizer’s Xalkori – were approved in about half that time because of improved genetic screening, more definitive Phase I trials and the dire need for new, effective treatments.

“We hope to be able to shave years off the time it takes to get final approval and save hundreds of millions of dollars per drug,” said Robert Schneider, director of translational cancer research at New York University Cancer Institute.

Smoking lung cancer (Photo credit: Wikipedia)

High rates of lung cancer (indicated in this map by brown colors) are highly correlated with the Stroke Belt. (Photo credit: Wikipedia)

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Memory Insights

Posted in Biological Networks, Gene Regulation and Evolution, Cell Biology, Signaling & Cell Circuits, Genome Biology, Innovations in Neurophysiology & Neuropsychology, tagged California sea hare, Long-term memory, Mitogen-activated protein kinase, New York University, Proceedings of the National Academy of Sciences of the United States of America, Protein kinase A, Thomas Carew, University of California Irvine on October 20, 2012| Leave a Comment »

Larry H. Bernstein, MD, Reporter

This is another very interesting contribution. I submit without change.

Neuroscientists find the molecular “when”, “where” of memory formation

Fri, 10/19/2012 – 11:30am

Neuroscientists from New York University and the University of California, Irvine have isolated the “when” and “where” of molecular activity that occurs in the formation of short-, intermediate-, and long-term memories. Their findings, which appear the Proceedings of the National Academy of Sciences, offer new insights into the molecular architecture of memory formation and, with it, a better roadmap for developing therapeutic interventions for related afflictions.

“Our findings provide a deeper understanding of how memories are created,” explains the research team leader Thomas Carew, a professor in NYU’s Center for Neural Science and dean of NYU’s Faculty of Arts and Science. “Memory formation is not simply a matter of turning molecules on and off; rather, it results from a complex temporal and spatial relationship of molecular interaction and movement.”

Neuroscientists have previously uncovered different aspects of molecular signaling relevant to the formation of memories. But less understood is the spatial relationship between molecules and when they are active during this process.

To address this question, the researchers studied the neurons inAplysia californica, the California sea slug. Aplysia is a model organism that is quite powerful for this type of research because its neurons are 10 to 50 times larger than those of higher organisms, such as vertebrates, and it possesses a relatively small network of neurons—characteristics that readily allow for the examination of molecular signaling during memory formation. Moreover, its coding mechanism for memories is highly conserved in evolution, and thus is similar to that of mammals, making it an appropriate model for understanding how this process works in humans.

The scientists focused their study on two molecules, MAPK and PKA, which earlier research has shown to be involved in many forms of memory and synaptic plasticity—that is, changes in the brain that occur after neuronal interaction. But less understood was how and where these molecules interacted.

English: Figure 1: A possible mechanism of cAMP/PKA inhibition of ERK activation (MAPK pathway). cAMP activation of PKA activates Rap1 via Src. Rap1 then phosphorylates Ras and inhibits signaling to Raf-1. (Photo credit: Wikipedia)

To explore this, the researchers subjected the sea slugs to sensitization training, which induces increased behavioral reflex responsiveness following mild tail shock, or in this study, mild activation of the nerve form the tail. They then examined the subsequent molecular activity of both MAPK and PKA. Both molecules have been shown to be involved in the formation of memory for sensitization, but the nature of their interaction is less clear.

What they found was MAPK and PKA coordinate their activity both spatially and temporally in the formation of memories. Specifically, in the formation of intermediate-term (for example, hours) and long-term (for example, days) memories, both MAPK and PKA activity occur, with MAPK spurring PKA action. By contrast, for short-term memories (for example, less than 30 min), only PKA is active, with no involvement of MAPK.

Source: New York University