Live Notes from @AACR’s #cbi16 Meeting on Precision Medicine: 3:45PM Big Idea Dr. Hait and Premalignancy
Big Idea: Interception: Search for therapies that can tackle pre-malignancies to prevent cancer by Dr. Williams Hait, Global Head Drug Discovery Jansenn
Reporter: Stephen J. Williams, Ph.D.
- We accumulate diseases over our lifetime
- Jannsen decided to come up with the term “immorbidity” living longer without fear of disease
- genetic complexity of cancers increase over time Nature 2012 paper
- with Gleevec different relapse picture with early than advanced disease (see my post on Gleevec resistance)
- cancer prevention screens have been important (Pap smears, colonoscopies)
- MGuS (myeloma precursor) to SMM then full blown disease
- huge knowledge gap in premalignant myeloma disease and karyotypic changes
- Jannsen is focusing on disease prevention
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