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Posts Tagged ‘JNJ’


 Live Notes from @AACR’s #cbi16 Meeting on Precision Medicine: 3:45PM Big Idea Dr. Hait and Premalignancy

Big Idea: Interception: Search for therapies that can tackle pre-malignancies to prevent cancer by Dr. Williams Hait, Global Head Drug Discovery Jansenn

Reporter: Stephen J. Williams, Ph.D.

  • We accumulate diseases over our lifetime
  • Jannsen decided to come up with the term “immorbidity” living longer without fear of disease
  • genetic complexity of cancers increase over time Nature 2012 paper
  • with Gleevec different relapse picture with early than advanced disease (see my post on Gleevec resistance)
  • cancer prevention screens have been important (Pap smears, colonoscopies)
  • MGuS (myeloma precursor) to SMM then full blown disease
  • huge knowledge gap in premalignant myeloma disease and karyotypic changes
  • Jannsen is focusing on disease prevention

 

 

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