Series E: e-Books on Patient-centered Medicine
Series E: Content Consultant: Larry H Bernstein, MD, FCAP
VOLUME FOUR
Medical 3D BioPrinting – The Revolution in Medicine
Technologies for Patient-centered Medicine:
From R&D in Biologics to New Medical Devices
@M3DP, LPBI Group
Editors
Larry H Bernstein, MD, FCAP
and
Aviva Lev-Ari, PhD, RN
Editor-in-Chief BioMed e-Series of e-Books
Leaders in Pharmaceutical Business Intelligence, Boston
avivalev-ari@alum.berkeley.edu
Available on Kindle Store @ Amazon.com since 12/30/2017
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- Publisher: Leaders in Pharmaceutical Business Intelligence; 1 edition (December 30, 2017)
- Publication Date: December 30, 2017
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- Language: English
- ASIN: B078QVDV2W
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Other e-Books in the BioMedicine e-Series
Series A: e-Books on Cardiovascular Diseases
Content Consultant: Justin D Pearlman, MD, PhD, FACC
Volume One: Perspectives on Nitric Oxide
Sr. Editor: Larry Bernstein, MD, FCAP, Editor: Aviral Vatsa, PhD and Content Consultant: Stephen J Williams, PhD
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B00DINFFYC
Volume Two: Cardiovascular Original Research: Cases in Methodology Design for Content Co-Curation
Curators: Justin D Pearlman, MD, PhD, FACC, Larry H Bernstein, MD, FCAP and
Aviva Lev-Ari, PhD, RN
- Causes
- Risks and Biomarkers
- Therapeutic Implication
Available on Kindle Store @ Amazon.com
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Volume Three: Etiologies of Cardiovascular Diseases: Epigenetics, Genetics and Genomics
Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
- Causes
- Risks and Biomarkers
- Therapeutic Implications
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B018PNHJ84
Volume Four: Regenerative and Translational Medicine: The Therapeutics Promise for Cardiovascular Diseases
Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
- Causes
- Risks and Biomarkers
- Therapeutic Implications
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B019UM909A
Volume Five: Pharmaco-Therapies of Cardiovascular Diseases
Volume Curators: Larry H. Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
Work-in-Progress
Volume Six: Interventional Cardiology and Cardiac Surgery for Disease Diagnosis and Guidance of Treatment
Volume Curators: Justin D Pearlman, MD, PhD, FACC and Aviva Lev-Ari, PhD, RN
Work-in-Progress
In addition to the Seven Volumes of SERIES A: Cardiovascular Diseases, Not included in SERIES A is a Four Volume Series by Dr. Pearlman, Editor, on Cardiovascular Diseases, positioned as Academic Textbooks for Training Residents in Cardiology and Texts for CEU Courses in Cardiology [Hardcover, Softcover, e-Books].
- CVD 1: Causes of Cardiovascular Diseases
- CVD 2: Risk Assessment of Cardiovascular Diseases
- CVD 3: Management of Cardiovascular Diseases
- CVD 4: Volume Seven: Cardiac Imaging
Series B: e-Books on Genomics & Medicine
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One: Genomics Orientations for Personalized Medicine
Sr. Editor: Stephen J Williams, PhD
Editors: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
Available on Kindle Store @ Amazon.com
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Volume Two: Latest in Genomics Methodologies for Therapeutics: Gene Editing, NGS & BioInformatics, Simulations and the Genome Ontology
Editors: TBA
Work-in-Progress
INACTIVE – Volume Three: Institutional Leadership in Genomics
Editors: Aviva Lev-Ari, PhD, RN and TBA
Series C: e-Books on Cancer & Oncology
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One: Cancer Biology & Genomics for Disease Diagnosis
Sr. Editor: Stephen J Williams, PhD, Editors: Ritu Saxena, PhD, Tilda Barliya, PhD
Available on Kindle Store @ Amazon.com
http://www.amazon.com/dp/B013RVYR2K
Volume Two: Cancer Therapies: Metabolic, Genomics, Interventional, Immunotherapy and Nanotechnology in Therapy Delivery
Authors, Curators and Editors:
Larry H Bernstein, MD, FCAP and Stephen J Williams, PhD
Guest Authors:
Dror Nir, PhD and Tilda Barliya, PhD, Demet Sag, PhD, Ziv Raviv, PhD and Aviva Lev-Ari, PhD, RN
Available on Kindle Store @ Amazon.com
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INACTIVE – Volume Three: Cancer Patients’ Resources on Therapies
Sr. Editor: TBA
Series D: Metabolomics and BioMedicine, The Immune System, Infectious Diseases and Therapeutic Implications
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One: Metabolic Genomics and Pharmaceutics
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Available on Kindle Store @ Amazon.com
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Author, Curator and Editor: Sudipta Saha, PhD
VOLUME 3: The Immune System and Therapeutics
Author, Curator and Editor: Larry H Bernstein, MD, FCAP
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Series E: Patient-centered Medicine
Content Consultant: Larry H Bernstein, MD, FCAP
Volume One: The VOICES of Patients, Hospitals CEOs, Health Care Providers, Caregivers and Families: Personal Experience with Critical Care and Invasive Medical Procedures
Author, Curator and Editor: Larry H Bernstein, MD, FCAP and Co-Editor: Gail Thornton, Msc, PhD(c)
Available on Amazon.com since 10/16/2017
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Volume Two: Medical Scientific Discoveries for the 21st Century & Interviews with Scientific Leaders
Author, Curator and Editor: Larry H Bernstein, MD, FCAP
Available on Kindle Store @ Amazon.com since 12/9/2017
https://www.amazon.com/dp/B078313281
Volume Three: Milestones in Physiology & Discoveries in Medicine and Genomics
Author, Curator and Editor: Larry H Bernstein, MD, FCAP
Available on Kindle Store @ Amazon.com since 12/27/15
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Volume Four: Medical 3D BioPrinting – The Revolution in Medicine, Technologies for Patient-centered Medicine: From R&D in Biologics to New Medical Devices
Editors: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
Available on Kindle Store @ Amazon.com since 12/30/2017
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Our DOMAINS in Scientific Media
I. Pharmaceutical: Biologics, Small Molecules, Diagnostics
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III. Patient-centered Medicine: Focus on #1: Cardiovascular, #2: Cancer, #3: Physiology Metabolomics, Immunology
IV. Biomedicine, BioTech, and MedTech (Medical Devices)
V. HealthCare: Patient-centered Medicine and Personalized/Precision Medicine
This e-Book is a comprehensive review of recent Original Research on Medical 3D BioPrinting – The Revolution in Medicine. Technologies for Patient-Center Medicine: From R&D in Biologics to New Medical Devices @M3DP, a subsidiary of LPBI Group.
The articles were written by Experts, Authors, Writers. The results of Original Research are gaining value added for the e-Reader by the Methodology of Curation. The e-Book’s articles have been published on the Open Access Online Scientific Journal, since April 2012. All new articles on this subject, will continue to be incorporated, as published with periodical updates.
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Is a scientific, medical and business, multi-expert authoring environment for information syndication in several domains of Life Sciences, Medicine, Pharmaceutical and Healthcare Industries, BioMedicine, Medical Technologies & Devices. Scientific critical interpretations and original articles are written by PhDs, MDs, MD/PhDs, PharmDs, Technical MBAs as Experts, Authors, Writers (EAWs) on an Equity Sharing basis.
Preface
Medical 3D printing has emerged in the early decades of the 21st century as a powerful tool for developing new tissues or new organs for use in surgery, diagnostics, and new drugs for medicine. In the first place it offers numerous opportunities in microscale development, and it offers a diagnostic opportunity to visual in 3 dimension scale. There are also emerging opportunities in radiology that will have relevance for diagnostics. The STL volume metric will have an enormous impact on anatomical studies and on teaching the will replace the no longer use of the cadaver.
List of Contributors
1.1, 1.2, 1.3, 1.4, 1.5, 1.7, 1.9, 2.3, 3.3, 3.10, 4.1, 4.2, 4.3, 4.8, 5.4, 7.1, 7.2, 7.3, 7.4, 7.5, 7.9, 7.10, 8.1, 8.2, 8.5, 9.1, 12.1, 12.2, 12.3, 12.8, 13.6
1.8, 1.14, 2.1, 2.2, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 2.10, 2.11, 3.1, 3.2, 3.4, 3.6, 3.7, 3.8, 3.9, 3.10, 4.10, 4.17, 5.2, 5.3, 6.3, 6.4, 6.5, 6.6, 6.11, 7.1, 7.6, 7.7, 8.2, 9.2, 9.3, 9.4, 9.6, 10.1, 10.2, 10.3, 11.4, 11.5, 12.5, 13.1, 13.4, 13.7
1.6, 1.12, 1.12.1, 1.12.2, 1.13.1, 1.15, 1.16, 4.4, 4.4.1, 4.5, 4.6, 4.9.1, 4.11, 4.12, 4.14, 4.14.1, 4.15, 4.16, 5.1, 5.5, 6.9, 6.12, 6.13, 7.8, 8.3, 8.4, 9.7, 9.8, 10.4, 12.1.1, 12.1.2, 12.4, 12.8.1, 12.8.2, 12.8.3, 12.9, 12.10, 13.3, 13.5
1.10, 6.1, 6.2, 6.7, 6.10, 12.7, 13.2
1.11, 4.7, 4.9, 6.8, 9.5, 10.5, 11.1, 11.6
1.13
3.5, 4.13
5.2, 9.3, 11.3
11.2
12.6
Gail S. Thornton, M.A., PhD(c)
4.18, 4.19
Abbreviated eTOCs
Chapter 1: 3D Bioprinting: Latest Innovations in a Forty year-old Technology
1.4 3-D Printing
1.6 Low-cost 3-D printer-based organ model production technique
1.7 Augmentation of the ONTOLOGY of the 3D Printing Research
1.8 ‘Pop-up’ fabrication technique trumps 3D printing
1.9 High resolution 3-D optics
1.10 Bio-Inks and 3D BioPrinting
1.11 4D Printing as a Time Dependent 3D Printing
1.12 Platform Technologies for Directly Reconstructing 3D Living Biomaterials
1.12.1 3D Printing Technique with Non-Contact Ultrasonic Manipulation Technology
1.12.2 3D printed microfibers used to reinforce hydrogels
1.13 Introduction to Tissue Engineering; Nanotechnology applications
1.13.1 Ferritin-cage-enzyme-encapsulation-as-a-new-platform-for-nanotechnology/
1.14 Scientists take “4D printing” a step further
1.15 Chemical Giant BASF Teams With Poietis on 4D Bioprinted Skin Project
1.16 3-D Printing in Water using Novel Hybrid Nanoparticles
Chapter 2: LPBI Initiative on 3D BioPrinting
2.1 Repository for LPBI’s Initiative on Medical 3D Printing
2.3 Augmentation of the ONTOLOGY of the 3D Printing Research
2.8 Transaction-based Web Site Design Considerations for M3DP
2.11 Global Technology Conferences on 3D BioPrinting 2015 – 2016
Chapter 3: Cardiovascular BioPrinting
3.1 Printing the Human Body: How It Works and Where It Is Headed
3.2 3-D BioPrinting in use to create Cardiac Living Tissue: Print Your Heart Out
3.3 Carnegie Scientists 3-D print a heart
3.4 3D Printed Heart Model Helps Change Prognosis for 5-Year-Old Mia – YouTube
3.5 Advances in 3D Printing of the human heart for surgical planning: MRI vs CT
3.6 From Scans, Doctors 3D Print Custom Heart Wraps to Deliver Treatments
3.7 Hybrid Imaging 3D Model of a Human Heart by Cardiac Imaging Techniques: CT and Echocardiography
3.8 3D Printing Brought to Bear on Cerebral Aneurysms
3.9 Capillaries: A Mapping Geometrical Method using Organ 3D Printing
3.10 Three-Dimensional Fibroblast Matrix Improves Left Ventricular Function Post MI
Chapter 4: Medical and Surgical Repairs – Advances in R&D Research
4.1 3D revolution and tissue repair
4.2 Huge advance in burn surgery
4.3 3D DNA Images and Nanoscale Design of Printed Vascular Tissue
4.4 New Spinal Cord Repair Strategy using 3D Cell Growth
4.4.1 3D “Squeeze” Helps Adult Cells Become Stem Cells
4.5 3D Printer Breakthrough for Bone Grafts
4.6 3D bioprinted carbon nanotubes used to stimulate bone regrowth
4.7 Medical 3D Printing and Metals in use in Medical Devices
4.8 Drug ‘Chemputer’
4.9 How 3D Printing Can Save a Life
4.9.1 3D prints bacteria to create organically reactive material
4.10 Surgical Separation of Conjoined Twins been Computer-Aided with CT and 3D BioPrinting
4.12 Materialise 3D Software Leads to Successful Jaw Replacement Surgery
4.14 Brain Surgeons Use 3D Printing to Practice
4.14.1 3D Printing Confirms Physical Model of Brain Folds
4.15 Stratasys Part of New CYBER Team for 3D Printed Orthotic Devices Targeting Veterans
4.16 First 3D Printed Tibia Replacement
4.18 The Future of Hospitals – How Medical Care and Technology Work Together to Advance Patient Care
4.19 Swiss Paraplegic Centre, Nottwil, Switzerland – A World-Class Clinic for Spinal Cord Injuries
Chapter 5: Organ on a Chip
5.1 Organs-on-Chips: An Alternative to 3D Bioprinting?
5.4 Curbing Cancer Cell Growth & Metastasis-on-a-Chip’ Models Cancer’s Spread
5.5 Google Glass Meets Organs-on-Chips
Chapter 6: FDA Regulatory Technology Issues
6.1 FDA Guidance on Use of Xenotransplanted Products in Human: Implications in 3D Printing
6.2 Update on FDA Policy Regarding 3D Bioprinted Material
6.4 FDA approves a drug manufactured using 3D printing
6.5 FDA-Approved 3D Printed Face Implant is a First
6.6 FDA’s “510(k)” given to 85 Medical Devices manufactured through 3D Printing Technology
6.8 GE’s $40 Million Center for Additive Technology Advancement (CATA)
6.9 Aprecia Pharmaceuticals Set to Advance 3D Printed Drug Pipeline
6.10 Twitter Analytics on the Inside 3DPrinting Conference #I3DPConf
6.12 Development of 3D Human Tissue Models Awarded NIH Grants Worth $15M
6.13 Clinical Trials Could Lead to FDA Approval for Artificial Pancreas
Chapter 7: DNA Origami
7.1 Gene Editing: The Role of Oligonucleotide Chips
7.2 The Binding of Oligonucleotides in DNA and 3-D Lattice Structures
7.3 3D DNA Images and Nanoscale Design of Printed Vascular Tissue
7.4 New DNA replication mechanism
7.5 DNA and Origami
7.8 Nanoparticles Used to Levitate Cells in Tissue Culture
7.10 Biofabrication with Stem Cells
Chapter 8: Aptamers and 3D Scaffold Binding
8.1 Antibody alternatives in specific aptamer 3-D scaffold binding
8.2 Neoangiogenic Effect of Grafting an Acellular 3-Dimensional Collagen Scaffold Onto Myocardium
8.3 3D-printed organ research enhanced with programmable DNA “smart glue”
8.4 New Scaffold-Free 3D Bioprinting Method Available to Researchers
Chapter 9: Advances and Future Prospects
9.1 The Scientist Who Is Making 3D Printing More Human
9.2 Stratasys Groundbreaking Multi-Color, Multi-Material 3D Printing Now Available
9.4 MIT researchers invent process for 3D-printing complex transparent glass forms
9.5 Sound of Music and Fancy Lights with 3D Printing
9.6 A 3D-printed mini jet engine that performs at 33,000 RPM
9.7 3D Printing Technique with Non-Contact Ultrasonic Manipulation Technology
9.8 BioP3 technology could be an alternative to bioprinting organs
Chapter 10: BioInks and MEMS
10.1 Medical MEMS, Sensors and 3D Printing: Frontier in Process Control of BioMaterials
10.4 3D prints bacteria to create organically reactive material
10.5 Nano metal inks
Chapter 11: BioMedical MEMS
11.1 BioMEMS based Optical Sensors
11.4 BioMEMS – Biological microelectromechanical systems
11.5 Medical MEMS, BioMEMS and Sensor Applications
11.6 Applications in Medicine of Piezoelectric Mini Cantilever Beam
Chapter 12: 3D Solid Organ Printing
12.1 3-D Printed Liver
12.1.1 Liver on the chip devices with the capacity to replace animal experiments
12.1.2 Newly discovered cells regenerate liver tissue without forming tumors
12.3 3-D Printed Ear
12.4 Silk Biomaterials Produced from 3D Bone Marrow Generate Platelets
12.5 Retina cells 3D printed for the first time
12.7 Lab Grown Brains and more from Twittersphere on 3D Bio-Printing News
12.8 Organoid Development
12.8.1 New technology for printing new tissues with living cellular bioink kits
12.8.2 Mini-kidney organoids re-create disease in lab dishes
12.8.3 How to Feed Engineered Organs using a 3D Printed Sugar Network
12.9 3-D Printed Ovaries Produce Healthy Offspring
12.10 World’s First 3D-printed ‘Sneezeometer’ Will Help Asthma Patients
Chapter 13: Medical 3D Printing: Sources and Trade Groups – List of Secondary Material
13.1 SOURCES on 3D Printing for Medical Applications
13.2 Join These Medical 3D Printing Groups on Twitter and LinkedIn
13.3 BioP3 technology could be an alternative to bioprinting organs
13.4 Medical 3D Printing Market Opportunities and 2024 Forecasts
13.5 Global 3D Bioprinting Market: Industry Size, Share and Segments Analysis to 2015 – 2021
13.6 GE’s large scale 3D cookbook
Preface
This e-Book establishes M3DP Team @LPBI Group as a Key Opinion Leader (KOL) in Patient-Center Medicine focusing on 3D BioPrinting as an agent in Personalized and Precision Medicine.
Introduction by Larry H Bernstein, MD, FCAP
This volume is focused only on the emerging field of 3D medical discovery and its impact on teaching physicians and surgeons, surgical procedures and on potential pharmaceutical applications. It is resident in medical devices and applications at the micro- and the macro- scale. The chapters that follow provide insight into how this development will fuel new drug development, diagnostics, and joint or tissue replacement. This would have applications in joint replacement, burn and trauma surgery, and even possibly cancer treatment.
The potential implications of Nanoscribe’s Photonic Professional GT point to much more important developments then micro-replicated artifacts and figures. This printing technology is being used to develop advanced medical practices that will help with previously difficult processes such as delivering drugs via micro-robots, targeting specific cancer cells, and even assisting in difficult eye operations.
Chapter 1
3D BioPrinting: Latest Innovations in a Forty year-old Technology
Curator: Larry H. Bernstein, MD, FCAP
Curator: Larry H. Bernstein, MD, FCAP
Curator: Larry H. Bernstein, MD, FCAP
1.4 3-D Printing
Curator: Larry H. Bernstein, MD, FCAP
Curator: Larry H. Bernstein, MD, FCAP
1.6 Low-cost 3-D printer-based organ model production technique
Reporter: Irina Robu, PhD
1.7 Augmentation of the ONTOLOGY of the 3D Printing Research
Curator: Larry H. Bernstein, MD, FCAP
1.8 ‘Pop-up’ fabrication technique trumps 3D printing
Reporter: Aviva Lev-Ari, PhD, RN
1.9 High resolution 3-D optics
Curator: Larry H. Bernstein, MD, FCAP
1.10 Bio-Inks and 3D BioPrinting
Curator: Stephen J. Williams, PhD
1.11 4D Printing as a Time Dependent 3D Printing
Curator: Danut Dragoi, PhD
1.12 Platform Technologies for Directly Reconstructing 3D Living Biomaterials
Reporter: Irina Robu, PhD
1.12.1 3D Printing Technique with Non-Contact Ultrasonic Manipulation Technology
Reporter: Irina Robu, PhD
1.12.2 3D printed microfibers used to reinforce hydrogels
Reporter: Irina Robu, PhD
1.13 Introduction to Tissue Engineering; Nanotechnology applications
Author, Editor and Curator: Tilda Barliya, PhD
1.13.1 Ferritin-cage-enzyme-encapsulation-as-a-new-platform-for-nanotechnology/
Reporter: Irina Robu, PhD
1.14 Scientists take “4D printing” a step further
Reporter: Aviva Lev-Ari, PhD, RN
1.15 Chemical Giant BASF Teams With Poietis on 4D Bioprinted Skin Project
Reporter: Irina Robu, PhD
1.16 3-D Printing in Water using Novel Hybrid Nanoparticles
Reporter: Irina Robu, PhD
Chapter 2
LPBI Initiative on 3D Printing
2.1 Repository for LPBI’s Initiative on Medical 3D Printing
Reporter: Aviva Lev-Ari, PhD, RN
Curator: Aviva Lev-Ari, PhD, RN
2.3 Augmentation of the ONTOLOGY of the 3D Printing Research
Curator: Larry H. Bernstein, MD, FCAP
Curator: Aviva Lev-Ari, PhD, RN
Curator: Aviva Lev-Ari, PhD, RN
Curator: Aviva Lev-Ari, PhD, RN
Curator: Aviva Lev-Ari, PhD, RN
2.8 Transaction-based Web Site Design Considerations for M3DP
Curator: Aviva Lev-Ari, PhD, RN
Curator: Aviva Lev-Ari, PhD, RN
Curator: Aviva Lev-Ari, PhD, RN
2.11 Global Technology Conferences on 3D BioPrinting 2015 – 2016
Curator: Aviva Lev-Ari, PhD, RN
Chapter 3
Cardiovascular BioPrinting
3.1 Printing the Human Body: How It Works and Where It Is Headed
Reporter: Aviva Lev-Ari, PhD, RN
3.2 3-D BioPrinting in use to create Cardiac Living Tissue: Print Your Heart Out
Reporter: Aviva Lev-Ari, PhD, RN
3.3 Carnegie Scientists 3-D print a heart
Curator: Larry H. Bernstein, MD, FCAP
3.4 3D Printed Heart Model Helps Change Prognosis for 5-Year-Old Mia – YouTube
Reporter: Aviva Lev-Ari, PhD, RN
3.5 Advances in 3D Printing of the human heart for surgical planning: MRI vs CT
Curator and Writer: Justin Pearlman MD PhD
3.6 From Scans, Doctors 3D Print Custom Heart Wraps to Deliver Treatments
Reporter: Aviva Lev-Ari, PhD, RN
3.7 Hybrid Imaging 3D Model of a Human Heart by Cardiac Imaging Techniques: CT and Echocardiography
Reporter: Aviva Lev-Ari, PhD, RN
3.8 3D Printing Brought to Bear on Cerebral Aneurysms
Reporter: Aviva Lev-Ari, PhD, RN
3.9 Capillaries: A Mapping Geometrical Method using Organ 3D Printing
Reporter: Aviva Lev-Ari, PhD, RN
3.10 Three-Dimensional Fibroblast Matrix Improves Left Ventricular Function Post MI
Curators: Larry H. Bernstein, MD. FCAP and Aviva Lev-Ari, PhD, RN
Chapter 4
Medical and Surgical Repairs
3-D Printing and its applications is a new endeavor that includes nonmedical invention as well as medical applications. The work is rapidly evolving and it constitutes an arena for tissue engineering, drug dosing and printing and artificial organ production and design.
4.1 3D revolution and tissue repair
Curator: Larry H. Bernstein, MD, FCAP
4.2 Huge advance in burn surgery
Curator: Larry H. Bernstein, MD, FCAP
4.3 3D DNA Images and Nanoscale Design of Printed Vascular Tissue
Curator: Larry H. Bernstein, MD, FCAP
4.4 New Spinal Cord Repair Strategy using 3D Cell Growth
Reporter: Irina Robu, PhD
4.4.1 3D “Squeeze” Helps Adult Cells Become Stem Cells
Reporter: Irina Robu, PhD
4.5 3D Printer Breakthrough for Bone Grafts
Reporter: Irina Robu, PhD
4.6 3D bioprinted carbon nanotubes used to stimulate bone regrowth
Reporter: Irina Robu, PhD
4.7 Medical 3D Printing and Metals in use in Medical Devices
Curator: Danut Dragoi, PhD
4.8 Drug ‘Chemputer’
Curator: Larry H. Bernstein, MD, FCAP
4.9 How 3D Printing Can Save a Life
Curator: Danut Dragoi, PhD
4.9.1 3D prints bacteria to create organically reactive material
Reporter: Irina Robu, PhD
4.10 Surgical Separation of Conjoined Twins been Computer-Aided with CT and 3D BioPrinting
Reporter: Aviva Lev-Ari, PhD, RN
Reporter: Irina Robu, PhD
4.12 Materialise 3D Software Leads to Successful Jaw Replacement Surgery
Reporter: Irina Robu, PhD
Curator and Writer: Justin Pearlman MD PhD
4.14 Brain Surgeons Use 3D Printing to Practice
Reporter: Irina Robu, PhD
4.14.1 3D Printing Confirms Physical Model of Brain Folds
Reporter: Irina Robu, PhD
4.15 Stratasys Part of New CYBER Team for 3D Printed Orthotic Devices Targeting Veterans
Reporter: Irina Robu, PhD
4.16 First 3D Printed Tibia Replacement
Reporter: Irina Robu, PhD
Reporter: Aviva Lev-Ari, PhD, RN
4.18 The Future of Hospitals – How Medical Care and Technology Work Together to Advance Patient Care
Curator: Gail S. Thornton, M.A., PhD(c)
4.19 Swiss Paraplegic Centre, Nottwil, Switzerland – A World-Class Clinic for Spinal Cord Injuries
Author: Gail S. Thornton, M.A., PhD(c)
We have reviewed the development of a whole new field of tissue engineering that will have a role in the future of medical treatment. Developments in this endeavor will also involve a science of nanotechnology.
Chapter 5
Organ on a Chip
5.1 Organs-on-Chips: An Alternative to 3D Bioprinting?
Reporter: Irina Robu, PhD
Curators: Gerard Loiseau, ESQ and Aviva Lev-Ari, PhD, RN
Reporter: Aviva Lev-Ari, PhD, RN
5.4 Curbing Cancer Cell Growth & Metastasis-on-a-Chip’ Models Cancer’s Spread
Curator: Larry H. Bernstein, MD, FCAP
5.5 Google Glass Meets Organs-on-Chips
Reporter: Irina Robu, PhD
Chapter 6
FDA Regulatory Technology Issues
6.1 FDA Guidance on Use of Xenotransplanted Products in Human: Implications in 3D Printing
Reporter: Stephen J. Williams, PhD
6.2 Update on FDA Policy Regarding 3D Bioprinted Material
Curator: Stephen J. Williams, PhD
Reporter: Aviva Lev-Ari, PhD, RN
6.4 FDA approves a drug manufactured using 3D printing
Reporter: Aviva Lev-Ari, PhD, RN
6.5 FDA-Approved 3D Printed Face Implant is a First
Reporter: Aviva Lev-Ari, PhD, RN
6.6 FDA’s “510(k)” given to 85 Medical Devices manufactured through 3D Printing Technology
Reporter: Aviva Lev-Ari, PhD, RN
Reporter: Stephen J. Williams, PhD
6.8 GE’s $40 Million Center for Additive Technology Advancement (CATA)
Reporter: Danut Dragoi, PhD
6.9 Aprecia Pharmaceuticals Set to Advance 3D Printed Drug Pipeline
Reporter: Irina Robu, PhD
6.10 Twitter Analytics on the Inside 3DPrinting Conference #I3DPConf
Reporter and Curator: Stephen J. Williams, PhD
Curator: Aviva Lev-Ari, PhD, RN
6.12 Development of 3D Human Tissue Models Awarded NIH Grants Worth $15M
Reporter: Irina Robu, PhD
6.13 Clinical Trials Could Lead to FDA Approval for Artificial Pancreas
Reporter: Irina Robu, PhD
Chapter 7
DNA Origami
7.1 Gene Editing: The Role of Oligonucleotide Chips
Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN
7.2 The Binding of Oligonucleotides in DNA and 3-D Lattice Structures
Curator: Larry H Bernstein, MD, FCAP
7.3 3D DNA Images and Nanoscale Design of Printed Vascular Tissue
Curator: Larry H. Bernstein, MD, FCAP
7.4 New DNA replication mechanism
Curator: Larry H. Bernstein, MD, FCAP
7.5 DNA and Origami
Curator: Larry H. Bernstein, MD, FCAP
Reporter: Aviva Lev-Ari, PhD, RN
Reporter: Aviva Lev-Ari, PhD, RN
7.8 Nanoparticles Used to Levitate Cells in Tissue Culture
Reporter: Irina Robu, PhD
Curators: Larry Bernstein, MD and Jennifer Schwartz, Ursulin College and Cleveland Clinic
7.10 Biofabrication with Stem Cells
Curator: Larry H. Bernstein, MD, FCAP
Chapter 8
Aptamers and 3D Scaffold Binding
8.1 Antibody alternatives in specific aptamer 3-D scaffold binding
Curator: Larry H. Bernstein, MD, FCAP
8.2 Neoangiogenic Effect of Grafting an Acellular 3-Dimensional Collagen Scaffold Onto Myocardium
Author: Larry H. Bernstein, MD, FCAP and Curator: Aviva Lev-Ari, PhD, RN
8.3 3D-printed organ research enhanced with programmable DNA “smart glue”
Reporter: Irina Robu, PhD
8.4 New Scaffold-Free 3D Bioprinting Method Available to Researchers
Reporter: Irina Robu, PhD
Curator: Larry H. Bernstein, MD, FCAP
Chapter 9
Advances and Future Prospects
9.1 The Scientist Who Is Making 3D Printing More Human
Curator: Larry H. Bernstein, MD, FCAP
9.2 Stratasys Groundbreaking Multi-Color, Multi-Material 3D Printing Now Available
Reporter: Aviva Lev-Ari, PhD, RN
Curators: Gerard Loiseau, ESQ and Aviva Lev-Ari, PhD, RN
9.4 MIT researchers invent process for 3D-printing complex transparent glass forms
Reporter: Aviva Lev-Ari, PhD, RN
9.5 Sound of Music and Fancy Lights with 3D Printing
Reporter: Danut Dragoi, PhD
9.6 A 3D-printed mini jet engine that performs at 33,000 RPM
Reporter: Aviva Lev-Ari, PhD, RN
9.7 3D Printing Technique with Non-Contact Ultrasonic Manipulation Technology
Reporter: Irina Robu, PhD
9.8 BioP3 technology could be an alternative to bioprinting organs
Reporter: Irina Robu, PhD
Chapter 10
Bioinks and MEMS
10.1 Medical MEMS, Sensors and 3D Printing: Frontier in Process Control of BioMaterials
Curators: Aviva Lev-Ari, PhD, RN and Adam Sonnenberg, BSc
Reporter: Aviva Lev-Ari, PhD, RN
Reporter: Aviva Lev-Ari, PhD, RN
10.4 3D prints bacteria to create organically reactive material
Reporter: Irina Robu, PhD
10.5 Nano metal inks
Reporter: Danut Dragoi, PhD
Chapter 11
Biomedical MEMS
11.1 BioMEMS based Optical Sensors
Author: Danut Dragoi, PhD
Curator: Stuart Cantor, PhD
Curator: Gérard LOISEAU, ESQ
11.4 BioMEMS – Biological microelectromechanical systems
Curator and Reporter: Aviva Lev-Ari, PhD, RN
11.5 Medical MEMS, BioMEMS and Sensor Applications
Curator and Reporter: Aviva Lev-Ari, PhD, RN
11.6 Applications in Medicine of Piezoelectric Mini Cantilever Beam
Curator: Danut Dragoi, PhD
Chapter 12
3D Solid Organ Printing
12.1 3-D Printed Liver
Curator: Larry H. Bernstein, MD, FCAP
12.1.1 Liver on the chip devices with the capacity to replace animal experiments
Reporter: Irina Robu, PhD
12.1.2 Newly discovered cells regenerate liver tissue without forming tumors
Reporter: Irina Robu, PhD
Curator: Larry H. Bernstein, MD, FCAP
12.3 3-D Printed Ear
Curator: Larry H. Bernstein, MD, FCAP
12.4 Silk Biomaterials Produced from 3D Bone Marrow Generate Platelets
Reporter: Irina Robu, PhD
12.5 Retina cells 3D printed for the first time
Reporter: Aviva Lev-Ari, PhD, RN
Curator: Evelina Cohn, PhD
12.7 Lab Grown Brains and more from Twittersphere on 3D Bio-Printing News
Curator: Stephen J. Williams, PhD
12.8 Organoid Development
Curator: Larry H. Bernstein, MD, FCAP
12.8.1 New technology for printing new tissues with living cellular bioink kits
Reporter: Irina Robu, PhD
12.8.2 Mini-kidney organoids re-create disease in lab dishes
Reporter: Irina Robu, PhD
12.8.3 How to Feed Engineered Organs using a 3D Printed Sugar Network
Reporter: Irina Robu, PhD
12.9 3-D Printed Ovaries Produce Healthy Offspring
Reporter: Irina Robu, PhD
12.10 World’s First 3D-printed ‘Sneezeometer’ Will Help Asthma Patients
Reporter: Irina Robu, PhD
Chapter 13
Medical 3D Printing: Sources and Trade Groups
List of Secondary Material
13.1 SOURCES on 3D Printing for Medical Applications
Curator: Aviva Lev-Ari, PhD, RN
13.2 Join These Medical 3D Printing Groups on Twitter and LinkedIn
Curator: Stephen J. Williams, PhD
13.3 BioP3 technology could be an alternative to bioprinting organs
Reporter: Irina Robu, PhD
13.4 Medical 3D Printing Market Opportunities and 2024 Forecasts
Reporter: Aviva Lev-Ari, PhD, RN
13.5 Global 3D Bioprinting Market: Industry Size, Share and Segments Analysis to 2015 – 2021
Reporter: Irina Robu, PhD
13.6 GE’s large scale 3D cookbook
Reporter: Larry H. Bernstein, MD, FCAP
Reporter: Aviva Lev-Ari, PhD, RN
Volume Summary and Conclusions
We have covered a broad range of topics in medicine, surgical repair, anatomical presentation and teaching, diagnostics, and even pharmaceutical development. In order to achieve this level of progress the dependence of 2D visualization had to be supplanted by 3D images, even at the molecular level. Examples of this at the macro level are organ replacement, tissue grafts, and introduction of organoids. Examples of this at the micro level are MEMS and sensors in their design, prototyping and manufacturing. In addition, there is an impact on drug development and targeting, nanotechnology, and in drug delivery, and organ transplants (heart, kidney).
EPILOGUE
The previous series of articles showed a remarkable development of techniques involving tissue and organ remodeling or replacement, a new scale of pharma engineering, an increasing load of FDA approved bioengineering products, the development of biological glue, the application of DNA to polymer engineering, and a new scale of funding for bioengineering. This is the beginning and the continuation of a new age of medical bioengineering.