Series E: e-Books on Patient-centered Medicine

VOLUME FOUR

Medical 3D BioPrinting – The Revolution in Medicine

Technologies for Patient-centered Medicine:

From R&D in Biologics to New Medical Devices

@M3DP, LPBI Group

Larry H Bernstein, MD, FCAP

and

Aviva Lev-Ari, PhD, RN

 

Aviva Lev-Ari, PhD, RN

Editor-in-Chief BioMed e-Series of e-Books

Leaders in Pharmaceutical Business Intelligence, Boston

avivalev-ari@alum.berkeley.edu

This e-Book is a comprehensive review of recent Original Research on  Medical 3D BioPrinting – The Revolution in Medicine. Technologies for Patient-Center Medicine: From R&D in Biologics to New Medical Devices @M3DP, a subsidiary of LPBI Group.

The articles were written by Experts, Authors, Writers. The results of Original Research are gaining value added for the e-Reader by the Methodology of Curation. The e-Book’s articles have been published on the Open Access Online Scientific Journal, since April 2012.  All new articles on this subject, will continue to be incorporated, as published with periodical updates.

Open Access Online Journal

http://www.pharmaceuticalIntelligence.com

Is a scientific, medical and business, multi-expert authoring environment for information syndication in several domains of Life Sciences, Medicine, Pharmaceutical and Healthcare Industries, BioMedicine, Medical Technologies & Devices. Scientific critical interpretations and original articles are written by PhDs, MDs, MD/PhDs, PharmDs, Technical MBAs as Experts, Authors, Writers (EAWs) on an Equity Sharing basis.

 

Preface

Medical 3D printing has emerged in the early decades of the 21^st century as a powerful tool for developing new tissues or new organs for use in surgery, diagnostics, and new drugs for medicine. In the first place it offers numerous opportunities in microscale development, and it offers a diagnostic opportunity to visual in 3 dimension scale. There are also emerging opportunities in radiology that will have relevance for diagnostics. The STL volume metric will have an enormous impact on anatomical studies and on teaching the will replace the no longer use of the cadaver.

List of Contributors

Larry H. Bernstein, MD, FCAP

1.1, 1.2, 1.3, 1.4, 1.5, 1.7, 1.9, 2.3, 3.3, 3.10, 4.1, 4.2, 4.3, 4.8, 5.4, 7.1, 7.3, 7.4, 7.5, 7.9, 7.10, 8.1, 8.2, 8.5, 9.1, 12.1, 12.2, 12.3, 12.8, 13.6

Aviva Lev-Ari, PhD, RN

1.8, 1.14, 2.1, 2.2, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 2.10, 2.11, 3.1, 3.2, 3.4, 3.6, 3.7, 3.8, 3.9, 3.10, 4.10, 4.17, 5.2, 5.3, 6.3, 6.4, 6.5, 6.6, 6.11, 7.1, 7.6, 7.7, 8.2, 9.2, 9.3, 9.4, 9.6, 10.1, 10.2, 10.3, 11.4, 11.5, 12.5, 13.1, 13.4, 13.7

Irina Robu, PhD

1.6, 1.12, 1.12.1, 1.12.2, 1.13.1, 1.15, 1.16, 4.4, 4.4.1, 4.5, 4.6, 4.9.1, 4.11, 4.12, 4.14, 4.14.1, 4.15, 4.16, 5.1, 5.5, 6.9, 6.12, 6.13, 7.8, 8.3, 8.4, 9.7, 9.8, 10.4, 12.1.1, 12.1.2, 12.4, 12.8.1, 12.8.2, 12.8.3, 12.9, 12.10, 13.3, 13.5

Stephen J. Williams, PhD

1.10, 6.1, 6.2, 6.7, 6.10, 7.2, 12.7, 13.2

Danut Dragoi, PhD

1.11, 4.7, 4.9, 6.8, 9.5, 10.5, 11.1, 11.6

Tilda Barliya, PhD

1.13

Justin Pearlman MD PhD

3.5, 4.13

Gerard Loiseau, ESQ

5.2, 9.3, 11.3

Stuart Cantor, PhD

11.2

Evelina Cohn, PhD

12.6

Gail S. Thornton, M.A., PhD(c)

4.18, 4.19

 

Abbreviated eTOCs

Chapter 1:  3D Bioprinting: Latest Innovations in a Forty year-old Technology

1.1  What is 3-D Printing

1.2  3-D Printing Overview

1.3  Bioprinting basics 

1.4  3-D Printing

1.5  3-D Printed Organs 

1.6  Low-cost 3-D printer-based organ model production technique

1.7  Augmentation of the ONTOLOGY of the 3D Printing Research

1.8  ‘Pop-up’ fabrication technique trumps 3D printing

1.9  High resolution 3-D optics

1.10  Bio-Inks and 3D BioPrinting

1.11  4D Printing as a Time Dependent 3D Printing

1.12  Platform Technologies for Directly Reconstructing 3D Living Biomaterials

1.12.1  3D Printing Technique with Non-Contact Ultrasonic Manipulation  Technology

1.12.2  3D printed microfibers used to reinforce hydrogels

1.13   Introduction to Tissue Engineering; Nanotechnology applications

1.13.1   Ferritin-cage-enzyme-encapsulation-as-a-new-platform-for-nanotechnology/

1.14   Scientists take “4D printing” a step further

1.15   Chemical Giant BASF Teams With Poietis on 4D Bioprinted Skin Project

1.16  3-D Printing in Water using Novel Hybrid Nanoparticles 

 

Chapter 2: LPBI Initiative on 3D BioPrinting

2.1   Repository for LPBI’s Initiative on Medical 3D Printing

2.2   Ontology Building for Medical 3D Printing: The Team @ Leaders in Pharmaceutical Business Intelligence (LPBI)

2.3   Augmentation of the ONTOLOGY of the 3D Printing Research

2.4   Twelve Lecture Series on Medical 3D Printing Applications & Technologies by LPBI’s Medical 3D Printing Team

2.5   LPBI’s Perspective on Medical and Life Sciences Applications – 3D Printing: BioInks, BioMaterials-BioPolymer

2.6   LPBI’s Perspective on Technologies Platforms & Tools in the Production and Process Control of Components & Systems using BioMaterials, BioPrinting and BioFabrication

2.7   LPBI’s Plan to LAUNCH a US based ’S’ Corporation – A Global Distributorship of 3D Printing and related BioMedical Technologies, DBA, LM-3DP-GD

2.8  Transaction-based Web Site Design Considerations for M3DP

2.9   3D Medical BioPrinting Technology Reporting by Irina Robu, PhD – a forthcoming Article in “Medical 3D BioPrinting – The Revolution in Medicine, Technologies for Patient-centered Medicine: From R&D in Biologics to New Medical Devices”

2.10  Presentation Series by M3DP Team @LPBI Group on Medical Applications of 3D BioPrinting, 8/2015 – 12/2015 and 1/2016 – 3/2016

2.11   Global Technology Conferences on 3D BioPrinting 2015 – 2016

 

Chapter 3: Cardiovascular BioPrinting

3.1  Printing the Human Body: How It Works and Where It Is Headed

3.2  3-D BioPrinting in use to create Cardiac Living Tissue: Print Your Heart Out

3.3   Carnegie Scientists 3-D print a heart

3.4   3D Printed Heart Model Helps Change Prognosis for 5-Year-Old Mia – YouTube

3.5   Advances in 3D Printing of the human heart for surgical planning: MRI vs CT

3.6   From Scans, Doctors 3D Print Custom Heart Wraps to Deliver Treatments

3.7   Hybrid Imaging 3D Model of a Human Heart by Cardiac Imaging Techniques: CT and Echocardiography

3.8   3D Printing Brought to Bear on Cerebral Aneurysms

3.9   Capillaries: A Mapping Geometrical Method using Organ 3D Printing

3.10  Three-Dimensional Fibroblast Matrix Improves Left Ventricular Function Post MI

 

Chapter 4: Medical and Surgical Repairs – Advances in R&D Research

 

4.1  3D revolution and tissue repair

4.2  Huge advance in burn surgery

4.3  3D DNA Images and Nanoscale Design of Printed Vascular Tissue

4.4 New Spinal Cord Repair Strategy using 3D Cell Growth

4.4.1 3D “Squeeze” Helps Adult Cells Become Stem Cells

4.5  3D Printer Breakthrough for Bone Grafts

4.6  3D bioprinted carbon nanotubes used to stimulate bone regrowth

4.7  Medical 3D Printing and Metals in use in Medical Devices

4.8  Drug ‘Chemputer’

4.9  How 3D Printing Can Save a Life

4.9.1 3D prints bacteria to create organically reactive material

4.10  Surgical Separation of Conjoined Twins been Computer-Aided with CT and 3D BioPrinting

4.11  Materialise Partners with University of Michigan and Tissue Regeneration Services for Clinical Trials of 3D Printed Tracheal Splint

4.12 Materialise 3D Software Leads to Successful Jaw Replacement Surgery

4.13  Progress towards 3D Bioprinting of blood supply: steps towards production of functional blood vessels presage production of other viable body part replacements

4.14 Brain Surgeons  Use 3D Printing to Practice   

4.14.1 3D Printing Confirms Physical Model of Brain Folds

4.15   Stratasys Part of New CYBER Team for 3D Printed Orthotic Devices Targeting Veterans

4.16  First 3D Printed Tibia Replacement

4.17  3D Printing for Surgical Planning: The Clinical and Economic Promise using Quantitative Clinical Evidence

4.18  The Future of Hospitals – How Medical Care and Technology Work Together to Advance Patient Care 

4.19  Swiss Paraplegic Centre, Nottwil, Switzerland – A World-Class Clinic for Spinal Cord Injuries

 

Chapter 5: Organ on a Chip

5.1  Organs-on-Chips: An Alternative to 3D Bioprinting?

5.2  Artificial Dentures: The Revolution of 3D Printing – Printed via Stereolithography (SLA), the resin dentures can be made directly from 3D models, instead of through Casts

5.3  Printing Cancer Tumors in 3D for Identification of Response to Drugs – Teleconference by Prof. Satchi-Fainaro, TAU, Medical School, 4/5/2016 noon EST

5.4  Curbing Cancer Cell Growth & Metastasis-on-a-Chip’ Models Cancer’s Spread

5.5  Google Glass Meets Organs-on-Chips

 

Chapter 6: FDA Regulatory Technology Issues

6.1  FDA Guidance on Use of Xenotransplanted Products in Human: Implications in 3D Printing

6.2  Update on FDA Policy Regarding 3D Bioprinted Material

6.3  NIH and FDA on 3D Printing in Medical Applications: Views for On-demand Drug Printing, in-Situ direct Tissue Repair and Printed Organs for Live Implants

6.4  FDA approves a drug manufactured using 3D printing

6.5  FDA-Approved 3D Printed Face Implant is a First

6.6  FDA’s “510(k)” given to 85 Medical Devices manufactured through 3D Printing Technology

6.7  New FDA Draft Guidance On Homologous Use of Human Cells, Tissues, and Cellular and Tissue-Based Products – Implications for 3D BioPrinting of Regenerative Tissue

6.8  GE’s $40 Million Center for Additive Technology Advancement (CATA)

6.9  Aprecia Pharmaceuticals Set to Advance 3D Printed Drug Pipeline

6.10  Twitter Analytics on the Inside 3DPrinting Conference #I3DPConf

6.11  Pharmacotyping Pancreatic Cancer Patients in the Future: Two Approaches – ORGANOIDS by David Tuveson and Hans Clevers and/or MICRODOSING Devices by Robert Langer

6.12 Development of 3D Human Tissue Models Awarded NIH Grants Worth $15M

6.13 Clinical Trials Could Lead to FDA Approval for Artificial Pancreas

Chapter 7: DNA Origami

7.1  Gene Editing: The Role of Oligonucleotide Chips

7.2  The Binding of Oligonucleotides in DNA and 3-D Lattice Structures

7.3  3D DNA Images and Nanoscale Design of Printed Vascular Tissue

7.4  New DNA replication mechanism

7.5  DNA and Origami

7.6  Researchers Combine Ideas of 3D Printing With Molecular Self-assembly – Is Molecular Manufacturing Next?

7.7  @MIT, Biological Engineering : new computer model that allows to design the most complex three-dimensional DNA shapes ever produced

7.8  Nanoparticles Used to Levitate Cells in Tissue Culture

7.9  Dialysis alternative

7.10  Biofabrication with Stem Cells

 

Chapter 8: Aptamers and 3D Scaffold Binding

8.1  Antibody alternatives in specific aptamer 3-D scaffold binding

8.2  Neoangiogenic Effect of Grafting an Acellular 3-Dimensional Collagen Scaffold Onto Myocardium

8.3  3D-printed organ research enhanced with programmable DNA “smart glue”

8.4  New Scaffold-Free 3D Bioprinting Method Available to Researchers

8.5  Aptamers and Scaffolds

 

Chapter 9: Advances and Future Prospects

9.1  The Scientist Who Is Making 3D Printing More Human

9.2  Stratasys Groundbreaking Multi-Color, Multi-Material 3D Printing Now Available

9.3  Neri Oxman and her Mediated Matter group @MIT Media Lab have developed a technique for 3D-printing Molten Glass

9.4  MIT researchers invent process for 3D-printing complex transparent glass forms

9.5  Sound of Music and Fancy Lights with 3D Printing

9.6  A 3D-printed mini jet engine that performs at 33,000 RPM

9.7 3D-Printed Body Parts Could Replace Cadavers for Medical Training

9.8 BioP3 technology could be an alternative to bioprinting organs

Chapter 10: BioInks and MEMS

10.1  Medical MEMS, Sensors and 3D Printing: Frontier in Process Control of BioMaterials

10.2  3D Printing Options: Printing 3D plastic structures in macroscopic scale or Printing in DNA at the Nanoscale

10.3  Classification of 3D BioPrinters used for Bioengineering and Biomaterials research or other Medical Applications

10.4  3D prints bacteria to create organically reactive material

10.5  Nano metal inks

 

Chapter 11: BioMedical MEMS

11.1  BioMEMS based Optical Sensors

11.2  Bio-MEMS Technologies: Devices, Tissue Engineering & Drug Delivery, Presentation by Stuart Cantor, Ph.D. on 2/4/16

11.3  BioMEMS The Market aspects of Oligonucleotide-Chips, Products, Applications and Competition, January 21, 2016

11.4  BioMEMS – Biological microelectromechanical systems

11.5  Medical MEMS, BioMEMS and Sensor Applications

11.6  Applications in Medicine of Piezoelectric Mini Cantilever Beam

 

Chapter 12: 3D Solid Organ Printing

12.1   3-D printed liver

12.1.1 Liver on the chip devices with the capacity to replace animal experiments

12.1.2 Newly discovered cells regenerate liver tissue without forming tumors

12.2   3-D Thyroid Bioprinted

12.3   3-D printed ear

12.4    Silk Biomaterials Produced from 3D Bone Marrow Generate Platelets

12.5   Retina cells 3D printed for the first time

12.6   Adipocyte Derived Stroma Cells: Their Usage in Regenerative Medicine and Reprogramming into Pancreatic Beta-Like Cells

12.7   Lab Grown Brains and more from Twittersphere on 3D Bio-Printing News

12.8   Organoid Development

12.8.1 New technology for printing new tissues with living cellular bioink kits

12.8.2 Mini-kidney organoids re-create disease in lab dishes

12.8.3 How to Feed Engineered Organs using a 3D Printed Sugar Network

12.9  3-D Printed Ovaries Produce Healthy Offspring

12.10 World’s First 3D-printed ‘Sneezeometer’ Will Help Asthma Patients 

Chapter 13: Medical 3D Printing: Sources and Trade Groups – List of Secondary Material

13.1   SOURCES on 3D Printing for Medical Applications

13.2   Join These Medical 3D Printing Groups on Twitter and LinkedIn

13.3   BioP3 technology could be an alternative to bioprinting organs

13.4   Medical 3D Printing Market Opportunities and 2024 Forecasts

13.5   Global 3D Bioprinting Market: Industry Size, Share and Segments Analysis to 2015 – 2021

13.6   GE’s large scale 3D cookbook

13.7  LIVE 11/16 1:15PM – 2:45PM – The 12th Annual Personalized Medicine Conference, HARVARD MEDICAL SCHOOL, Joseph B. Martin Conference Center, 77 Avenue Louis Pasteur, Boston

Preface

This e-Book establishes M3DP Team @LPBI Group as a Key Opinion Leader (KOL) in Patient-Center Medicine focusing on 3D BioPrinting as an agent in Personalized and Precision Medicine. 

 

The potential implications of Nanoscribe’s Photonic Professional GT point to much more important developments then micro-replicated artifacts and figures. This printing technology is being used to develop advanced medical practices that will help with previously difficult processes such as delivering drugs via micro-robots, targeting specific cancer cells, and even assisting in difficult eye operations.

 

Chapter 1

3D BioPrinting: Latest Innovations in a Forty year-old Technology

1.1  What is 3-D Printing

Curator: Larry H. Bernstein, MD, FCAP

 

1.2  3-D Printing Overview

Curator: Larry H. Bernstein, MD, FCAP

 

1.3  Bioprinting basics 

Curator: Larry H. Bernstein, MD, FCAP

 

1.4  3-D Printing

Curator: Larry H. Bernstein, MD, FCAP

 

1.5  3-D Printed Organs 

Curator: Larry H. Bernstein, MD, FCAP

 

1.6  Low-cost 3-D printer-based organ model production technique

Reporter: Irina Robu, PhD

 

1.7  Augmentation of the ONTOLOGY of the 3D Printing Research

Curator: Larry H. Bernstein, MD, FCAP

 

1.8  ‘Pop-up’ fabrication technique trumps 3D printing

Reporter: Aviva Lev-Ari, PhD, RN

 

1.9  High resolution 3-D optics

Curator: Larry H. Bernstein, MD, FCAP

 

1.10  Bio-Inks and 3D BioPrinting

Curator: Stephen J. Williams, PhD

 

1.11  4D Printing as a Time Dependent 3D Printing

Curator: Danut Dragoi, PhD

 

1.12  Platform Technologies for Directly Reconstructing 3D Living Biomaterials

Reporter: Irina Robu, PhD

 

1.12.1  3D Printing Technique with Non-Contact Ultrasonic Manipulation  Technology

Reporter: Irina Robu, PhD

 

1.12.2  3D printed microfibers used to reinforce hydrogels

Reporter: Irina Robu, PhD

 

1.13   Introduction to Tissue Engineering; Nanotechnology applications

Author, Editor and Curator:  Tilda Barliya, PhD

 

1.13.1   Ferritin-cage-enzyme-encapsulation-as-a-new-platform-for-nanotechnology/

Reporter: Irina Robu, PhD

 

1.14   Scientists take “4D printing” a step further

Reporter: Aviva Lev-Ari, PhD, RN

 

1.15   Chemical Giant BASF Teams With Poietis on 4D Bioprinted Skin Project

Reporter: Irina Robu, PhD 

 

1.16  3-D Printing in Water using Novel Hybrid Nanoparticles 

Reporter: Irina Robu, PhD 

 

 

Chapter 2

LPBI Initiative on 3D Printing

  

2.1   Repository for LPBI’s Initiative on Medical 3D Printing

Reporter: Aviva Lev-Ari, PhD, RN

 

2.2   Ontology Building for Medical 3D Printing: The Team @ Leaders in Pharmaceutical Business Intelligence (LPBI)

Curator: Aviva Lev-Ari, PhD, RN

 

2.3   Augmentation of the ONTOLOGY of the 3D Printing Research

Curator: Larry H. Bernstein, MD, FCAP

 

2.4   Twelve Lecture Series on Medical 3D Printing Applications & Technologies by LPBI’s Medical 3D Printing Team

Curator: Aviva Lev-Ari, PhD, RN

 

2.5   LPBI’s Perspective on Medical and Life Sciences Applications – 3D Printing: BioInks, BioMaterials-BioPolymer

Curator: Aviva Lev-Ari, PhD, RN

 

2.6   LPBI’s Perspective on Technologies Platforms & Tools in the Production and Process Control of Components & Systems using BioMaterials, BioPrinting and BioFabrication

Curator: Aviva Lev-Ari, PhD, RN

 

2.7   LPBI’s Plan to LAUNCH a US based ’S’ Corporation – A Global Distributorship of 3D Printing and related BioMedical Technologies, DBA, LM-3DP-GD

Curator: Aviva Lev-Ari, PhD, RN

 

2.8  Transaction-based Web Site Design Considerations for M3DP

Curator: Aviva Lev-Ari, PhD, RN

 

2.9   3D Medical BioPrinting Technology Reporting by Irina Robu, PhD – a forthcoming Article in “Medical 3D BioPrinting – The Revolution in Medicine, Technologies for Patient-centered Medicine: From R&D in Biologics to New Medical Devices”

Curator: Aviva Lev-Ari, PhD, RN

 

2.10  Presentation Series by M3DP Team @LPBI Group on Medical Applications of 3D BioPrinting, 8/2015 – 12/2015 and 1/2016 – 3/2016

Curator: Aviva Lev-Ari, PhD, RN

 

2.11   Global Technology Conferences on 3D BioPrinting 2015 – 2016

Curator: Aviva Lev-Ari, PhD, RN

 

 

Chapter 3

Cardiovascular BioPrinting

 

3.1  Printing the Human Body: How It Works and Where It Is Headed

Reporter: Aviva Lev-Ari, PhD, RN

 

3.2  3-D BioPrinting in use to create Cardiac Living Tissue: Print Your Heart Out

Reporter: Aviva Lev-Ari, PhD, RN

 

3.3   Carnegie Scientists 3-D print a heart

Curator: Larry H. Bernstein, MD, FCAP

 

3.4   3D Printed Heart Model Helps Change Prognosis for 5-Year-Old Mia – YouTube

Reporter: Aviva Lev-Ari, PhD, RN

 

3.5   Advances in 3D Printing of the human heart for surgical planning: MRI vs CT

Curator and Writer: Justin Pearlman MD PhD

 

3.6   From Scans, Doctors 3D Print Custom Heart Wraps to Deliver Treatments

Reporter: Aviva Lev-Ari, PhD, RN

 

3.7   Hybrid Imaging 3D Model of a Human Heart by Cardiac Imaging Techniques: CT and Echocardiography

Reporter: Aviva Lev-Ari, PhD, RN

 

3.8   3D Printing Brought to Bear on Cerebral Aneurysms

Reporter: Aviva Lev-Ari, PhD, RN

 

3.9   Capillaries: A Mapping Geometrical Method using Organ 3D Printing

Reporter: Aviva Lev-Ari, PhD, RN

 

3.10  Three-Dimensional Fibroblast Matrix Improves Left Ventricular Function Post MI

Curators: Larry H. Bernstein, MD. FCAP and Aviva Lev-Ari, PhD, RN

Chapter 4

Medical and Surgical Repairs

 

3-D Printing and its applications is a new endeavor that includes nonmedical invention as well as medical applications. The work is rapidly evolving and it constitutes an arena for tissue engineering, drug dosing and printing and artificial organ production and design.

 

4.1  3D revolution and tissue repair

Curator: Larry H. Bernstein, MD, FCAP

 

4.2  Huge advance in burn surgery

Curator: Larry H. Bernstein, MD, FCAP

 

4.3  3D DNA Images and Nanoscale Design of Printed Vascular Tissue

Curator: Larry H. Bernstein, MD, FCAP

 

4.4 New Spinal Cord Repair Strategy using 3D Cell Growth

Reporter: Irina Robu, PhD

 

4.4.1 3D “Squeeze” Helps Adult Cells Become Stem Cells

Reporter: Irina Robu, PhD

 

4.5  3D Printer Breakthrough for Bone Grafts

Reporter: Irina Robu, PhD

 

4.6  3D bioprinted carbon nanotubes used to stimulate bone regrowth

Reporter: Irina Robu, PhD

 

4.7  Medical 3D Printing and Metals in use in Medical Devices

Curator: Danut Dragoi, PhD

 

4.8  Drug ‘Chemputer’

Curator: Larry H. Bernstein, MD, FCAP

 

4.9  How 3D Printing Can Save a Life

Curator: Danut Dragoi, PhD

 

4.9.1 3D prints bacteria to create organically reactive material

Reporter: Irina Robu, PhD

 

4.10  Surgical Separation of Conjoined Twins been Computer-Aided with CT and 3D BioPrinting

Reporter: Aviva Lev-Ari, PhD, RN

 

4.11  Materialise Partners with University of Michigan and Tissue Regeneration Services for Clinical Trials of 3D Printed Tracheal Splint

Reporter: Irina Robu, PhD

 

4.12 Materialise 3D Software Leads to Successful Jaw Replacement Surgery

Reporter: Irina Robu, PhD

 

4.13  Progress towards 3D Bioprinting of blood supply: steps towards production of functional blood vessels presage production of other viable body part replacements

Curator and Writer: Justin Pearlman MD PhD

 

4.14 Brain Surgeons  Use 3D Printing to Practice   

Reporter: Irina Robu, PhD

 

4.14.1 3D Printing Confirms Physical Model of Brain Folds

Reporter: Irina Robu, PhD

 

4.15   Stratasys Part of New CYBER Team for 3D Printed Orthotic Devices Targeting Veterans

Reporter: Irina Robu, PhD

 

4.16  First 3D Printed Tibia Replacement

Reporter: Irina Robu, PhD

 

4.17  3D Printing for Surgical Planning: The Clinical and Economic Promise using Quantitative Clinical Evidence

Reporter: Aviva Lev-Ari, PhD, RN

 

4.18  The Future of Hospitals – How Medical Care and Technology Work Together to Advance Patient Care 

Curator: Gail S. Thornton, M.A., PhD(c)

 

4.19  Swiss Paraplegic Centre, Nottwil, Switzerland – A World-Class Clinic for Spinal Cord Injuries

Author: Gail S. Thornton, M.A., PhD(c)

 

We have reviewed the development of a whole new field of tissue engineering that will have a role in the future of medical treatment. Developments in this endeavor will also involve a science of nanotechnology.

Chapter 5

Organ on a Chip

 

5.1  Organs-on-Chips: An Alternative to 3D Bioprinting?

Reporter: Irina Robu, PhD

 

5.2  Artificial Dentures: The Revolution of 3D Printing – Printed via Stereolithography (SLA), the resin dentures can be made directly from 3D models, instead of through Casts

Curators: Gerard Loiseau, ESQ and Aviva Lev-Ari, PhD, RN

 

5.3  Printing Cancer Tumors in 3D for Identification of Response to Drugs – Teleconference by Prof. Satchi-Fainaro, TAU, Medical School, 4/5/2016 noon EST

Reporter: Aviva Lev-Ari, PhD, RN

 

5.4  Curbing Cancer Cell Growth & Metastasis-on-a-Chip’ Models Cancer’s Spread

Curator: Larry H. Bernstein, MD, FCAP

 

5.5 Google Glass Meets Organs-on-Chips 

Reporter: Irina Robu, PhD

 

Chapter 6

FDA Regulatory Technology Issues

 

6.1  FDA Guidance on Use of Xenotransplanted Products in Human: Implications in 3D Printing

Reporter: Stephen J. Williams, PhD

 

6.2  Update on FDA Policy Regarding 3D Bioprinted Material

Curator: Stephen J. Williams, PhD

 

6.3  NIH and FDA on 3D Printing in Medical Applications: Views for On-demand Drug Printing, in-Situ direct Tissue Repair and Printed Organs for Live Implants

Reporter: Aviva Lev-Ari, PhD, RN

 

6.4  FDA approves a drug manufactured using 3D printing

Reporter: Aviva Lev-Ari, PhD, RN

 

6.5  FDA-Approved 3D Printed Face Implant is a First

Reporter: Aviva Lev-Ari, PhD, RN

 

6.6  FDA’s “510(k)” given to 85 Medical Devices manufactured through 3D Printing Technology

Reporter: Aviva Lev-Ari, PhD, RN

 

6.7  New FDA Draft Guidance On Homologous Use of Human Cells, Tissues, and Cellular and Tissue-Based Products – Implications for 3D BioPrinting of Regenerative Tissue

Reporter: Stephen J. Williams, PhD

 

6.8  GE’s $40 Million Center for Additive Technology Advancement (CATA)

Reporter: Danut Dragoi, PhD

 

6.9  Aprecia Pharmaceuticals Set to Advance 3D Printed Drug Pipeline

Reporter: Irina Robu, PhD

 

6.10  Twitter Analytics on the Inside 3DPrinting Conference #I3DPConf

Reporter and Curator: Stephen J. Williams, PhD

 

6.11  Pharmacotyping Pancreatic Cancer Patients in the Future: Two Approaches – ORGANOIDS by David Tuveson and Hans Clevers and/or MICRODOSING Devices by Robert Langer

Curator: Aviva Lev-Ari, PhD, RN

 

6.12 Development of 3D Human Tissue Models Awarded NIH Grants Worth $15M 

Reporter: Irina Robu, PhD

 

6.13 Clinical Trials Could Lead to FDA Approval for Artificial Pancreas

Reporter: Irina Robu, PhD

Chapter 7

DNA Origami

 

7.1  Gene Editing: The Role of Oligonucleotide Chips

Curators: Larry H Bernstein, MD, FCAP and Aviva Lev-Ari, PhD, RN

 

7.2  The Binding of Oligonucleotides in DNA and 3-D Lattice Structures

Curator: Stephen J. Williams, PhD

 

7.3  3D DNA Images and Nanoscale Design of Printed Vascular Tissue

Curator: Larry H. Bernstein, MD, FCAP

 

7.4  New DNA replication mechanism

Curator: Larry H. Bernstein, MD, FCAP

 

7.5  DNA and Origami

Curator: Larry H. Bernstein, MD, FCAP

 

7.6  Researchers Combine Ideas of 3D Printing With Molecular Self-assembly – Is Molecular Manufacturing Next?

Reporter: Aviva Lev-Ari, PhD, RN

 

7.7  @MIT, Biological Engineering : new computer model that allows to design the most complex three-dimensional DNA shapes ever produced

Reporter: Aviva Lev-Ari, PhD, RN

 

7.8  Nanoparticles Used to Levitate Cells in Tissue Culture

Reporter: Irina Robu, PhD

 

7.9  Dialysis alternative

Curators: Larry Bernstein, MD and Jennifer Schwartz, Ursulin College and Cleveland Clinic

 

7.10  Biofabrication with Stem Cells

Curator: Larry H. Bernstein, MD, FCAP

 

 

Chapter 8

Aptamers and 3D Scaffold Binding

 

8.1  Antibody alternatives in specific aptamer 3-D scaffold binding

Curator: Larry H. Bernstein, MD, FCAP

 

8.2  Neoangiogenic Effect of Grafting an Acellular 3-Dimensional Collagen Scaffold Onto Myocardium

Author: Larry H. Bernstein, MD, FCAP and Curator: Aviva Lev-Ari, PhD, RN

 

8.3  3D-printed organ research enhanced with programmable DNA “smart glue”

Reporter: Irina Robu, PhD

 

8.4  New Scaffold-Free 3D Bioprinting Method Available to Researchers 

Reporter: Irina Robu, PhD

 

8.5  Aptamers and Scaffolds

Curator: Larry H. Bernstein, MD, FCAP

 

 

Chapter 9

Advances and Future Prospects

 

9.1  The Scientist Who Is Making 3D Printing More Human

Curator: Larry H. Bernstein, MD, FCAP

 

9.2  Stratasys Groundbreaking Multi-Color, Multi-Material 3D Printing Now Available

Reporter: Aviva Lev-Ari, PhD, RN

 

9.3  Neri Oxman and her Mediated Matter group @MIT Media Lab have developed a technique for 3D-printing Molten Glass

Curators: Gerard Loiseau, ESQ and Aviva Lev-Ari, PhD, RN

 

9.4  MIT researchers invent process for 3D-printing complex transparent glass forms

Reporter: Aviva Lev-Ari, PhD, RN

 

9.5  Sound of Music and Fancy Lights with 3D Printing

Reporter: Danut Dragoi, PhD

 

9.6  A 3D-printed mini jet engine that performs at 33,000 RPM

Reporter: Aviva Lev-Ari, PhD, RN

 

9.7  3D Printing Technique with Non-Contact Ultrasonic Manipulation Technology

Reporter: Irina Robu, PhD

 

9.8 BioP3 technology could be an alternative to bioprinting organs

Reporter: Irina Robu, PhD

 

Chapter 10

Bioinks and MEMS

 

10.1  Medical MEMS, Sensors and 3D Printing: Frontier in Process Control of BioMaterials

Curators: Aviva Lev-Ari, PhD, RN and Adam Sonnenberg, BSc

 

10.2  3D Printing Options: Printing 3D plastic structures in macroscopic scale or Printing in DNA at the Nanoscale

Reporter: Aviva Lev-Ari, PhD, RN

 

10.3  Classification of 3D BioPrinters used for Bioengineering and Biomaterials research or other Medical Applications

Reporter: Aviva Lev-Ari, PhD, RN

 

10.4  3D prints bacteria to create organically reactive material

Reporter: Irina Robu, PhD

 

10.5  Nano metal inks

Reporter: Danut Dragoi, PhD

 

Chapter 11

Biomedical MEMS

 

11.1  BioMEMS based Optical Sensors

Author: Danut Dragoi, PhD

 

11.2  Bio-MEMS Technologies: Devices, Tissue Engineering & Drug Delivery, Presentation by Stuart Cantor, Ph.D. on 2/4/16

Curator: Stuart Cantor, PhD

 

11.3  BioMEMS The Market aspects of Oligonucleotide-Chips, Products, Applications and Competition, January 21, 2016

Curator: Gérard LOISEAU, ESQ

 

11.4  BioMEMS – Biological microelectromechanical systems

Curator and Reporter: Aviva Lev-Ari, PhD, RN

 

11.5  Medical MEMS, BioMEMS and Sensor Applications 

Curator and Reporter: Aviva Lev-Ari, PhD, RN

 

11.6  Applications in Medicine of Piezoelectric Mini Cantilever Beam

Curator: Danut Dragoi, PhD

 

Chapter 12

3D Solid Organ Printing

 

12.1   3-D printed liver

Curator: Larry H. Bernstein, MD, FCAP

 

12.1.1 Liver on the chip devices with the capacity to replace animal experiments

Reporter: Irina Robu, PhD

 

12.1.2 Newly discovered cells regenerate liver tissue without forming tumors

Reporter: Irina Robu, PhD

 

12.2   3-D Thyroid Bioprinted

Curator: Larry H. Bernstein, MD, FCAP

 

12.3   3-D printed ear

Curator: Larry H. Bernstein, MD, FCAP

 

12.4    Silk Biomaterials Produced from 3D Bone Marrow Generate Platelets

Reporter: Irina Robu, PhD

 

12.5   Retina cells 3D printed for the first time

Reporter: Aviva Lev-Ari, PhD, RN

 

12.6   Adipocyte Derived Stroma Cells: Their Usage in Regenerative Medicine and Reprogramming into Pancreatic Beta-Like Cells

Curator: Evelina Cohn, PhD

 

12.7   Lab Grown Brains and more from Twittersphere on 3D Bio-Printing News

Curator: Stephen J. Williams, PhD

 

12.8   Organoid Development

Curator: Larry H. Bernstein, MD, FCAP

 

12.8.1 New technology for printing new tissues with living cellular bioink kits

Reporter: Irina Robu, PhD

 

12.8.2 Mini-kidney organoids re-create disease in lab dishes

Reporter: Irina Robu, PhD

 

12.8.3 How to Feed Engineered Organs using a 3D Printed Sugar Network

Reporter: Irina Robu, PhD

 

12.9  3-D Printed Ovaries Produce Healthy Offspring

Reporter: Irina Robu, PhD

 

12.10 World’s First 3D-printed ‘Sneezeometer’ Will Help Asthma Patients

Reporter: Irina Robu, PhD

Chapter 13

Medical 3D Printing: Sources and Trade Groups

List of Secondary Material

 

13.1   SOURCES on 3D Printing for Medical Applications

Curator: Aviva Lev-Ari, PhD, RN

 

13.2   Join These Medical 3D Printing Groups on Twitter and LinkedIn

Curator: Stephen J. Williams, PhD

 

13.3   BioP3 technology could be an alternative to bioprinting organs

Reporter: Irina Robu, PhD

 

13.4   Medical 3D Printing Market Opportunities and 2024 Forecasts

Reporter: Aviva Lev-Ari, PhD, RN

 

13.5   Global 3D Bioprinting Market: Industry Size, Share and Segments Analysis to 2015 – 2021

Reporter: Irina Robu, PhD

 

13.6 GE’s large scale 3D cookbook

Reporter: Larry H. Bernstein, MD, FCAP

 

13.7  LIVE 11/16 1:15PM – 2:45PM – The 12th Annual Personalized Medicine Conference, HARVARD MEDICAL SCHOOL, Joseph B. Martin Conference Center, 77 Avenue Louis Pasteur, Boston

Reporter: Aviva Lev-Ari, PhD, RN

 

 

Volume Summary and Conclusions

We have covered a broad range of topics in medicine, surgical repair, anatomical presentation and teaching, diagnostics, and even pharmaceutical development. In order to achieve this level of progress the dependence of 2D visualization had to be supplanted by 3D images, even at the molecular level. Examples of this at the macro level are organ replacement, tissue grafts, and introduction of organoids. Examples of this at the micro level are MEMS and sensors in their design, prototyping and manufacturing. In addition, there is an impact on drug development and targeting, nanotechnology, and in drug delivery, and organ transplants (heart, kidney).

 

EPILOGUE

The previous series of articles showed a remarkable development of techniques involving tissue and organ remodeling or replacement, a new scale of pharma engineering, an increasing load of FDA approved bioengineering products, the development of biological glue, the application of DNA to polymer engineering, and a new scale of funding for bioengineering. This is the beginning and the continuation of a new age of medical bioengineering.