Metabolic Genomics & Pharmaceutics
2015
http://www.amazon.com/dp/B012BB0ZF0
Author, Curator and Editor
Larry H Bernstein, MD, FCAP
Chief Scientific Officer
Leaders in Pharmaceutical Business Intelligence
Chapter 1: Metabolic Pathways
1.2 Studies of Respiration Lead to Acetyl CoA
1.3 Pentose Shunt, Electron Transfer, Galactose, more Lipids in brief
1.4 The Multi-step Transfer of Phosphate Bond and Hydrogen Exchange Energy
1.6 Glycosaminoglycans, Mucopolysaccharides, L-iduronidase, Enzyme Therapy
Chapter 2: Lipid Metabolism
2.1 Lipid Classification System
2.3 Lipid Oxidation and Synthesis of Fatty Acids
2.4 Cholesterol and Regulation of Liver Synthetic Pathways
2.5 Sex hormones, Adrenal cortisol, Prostaglandins
2.6 Cytoskeleton and Cell Membrane Physiology
2.7 Pharmacological Action of Steroid hormone
Chapter 3: Cell Signaling
3.1 Signaling and Signaling Pathways
3.2 Signaling Transduction Tutorial
3.3 Selected References to Signaling and Metabolic Pathways in Leaders in Pharmaceutical Intelligence
3.4 Integrins, Cadherins, Signaling and the Cytoskeleton
3.5 Complex Models of Signaling: Therapeutic Implications
3.6 Functional Correlates of Signaling Pathways
Chapter 4: Protein Synthesis and Degradation
4.1 The Role and Importance of Transcription Factors
4.2 RNA and the Transcription of the Genetic Code
4.4 Transcriptional Silencing and Longevity Protein Sir2
4.5 Ca2+ Signaling: Transcriptional Control
4.6 Long Noncoding RNA Network regulates PTEN Transcription
4.7 Zinc-Finger Nucleases (ZFNs) and Transcription Activator–Like Effector Nucleases (TALENs)
4.8 Cardiac Ca2+ Signaling: Transcriptional Control
4.9 Transcription Factor Lyl-1 Critical in Producing Early T-Cell Progenitors
4.10 Human Frontal Lobe Brain: Specific Transcriptional Networks
4.11 Somatic, Germ-cell, and Whole Sequence DNA in Cell Lineage and Disease
Chapter 5: Sub-cellular Structure
5.2 Mitochondrial Metabolism and Cardiac Function
5.3 Mitochondria: More than just the “Powerhouse of the Cell”
5.4 Mitochondrial Fission and Fusion: Potential Therapeutic Targets?
5.5 Mitochondrial Mutation Analysis might be “1-step” Away
5.7 Chromatophagy, A New Cancer Therapy: Starve The Diseased Cell Until It Eats Its Own DNA
5.9 Role of Calcium, the Actin Skeleton, and Lipid Structures in Signaling and Cell Motility
Chapter 6: Proteomics
6.1 Proteomics, Metabolomics, Signaling Pathways, and Cell Regulation: a Compilation of Articles in the Journal http://pharmaceuticalintelligence.com
6.2 A Brief Curation of Proteomics, Metabolomics, and Metabolism
6.3 Using RNA-seq and Targeted Nucleases to Identify Mechanisms of Drug Resistance in Acute Myeloid Leukemia, SK Rathe in Nature, 2014
6.4 Proteomics – The Pathway to Understanding and Decision-making in Medicine
6.5 Advances in Separations Technology for the “OMICs” and Clarification of Therapeutic Targets
6.6 Expanding the Genetic Alphabet and Linking the Genome to the Metabolome
6.7 Genomics, Proteomics and Standards
6.8 Proteins and Cellular Adaptation to Stress
6.9 Genes, Proteomes, and their Interaction
6.10 Regulation of Somatic Stem Cell Function
6.11 Scientists discover that Pluripotency factor NANOG is also active in Adult Organism
Chapter 7: Metabolomics
7.1 Extracellular Evaluation of Intracellular Flux in Yeast Cells
7.2 Metabolomic Analysis of Two Leukemia Cell Lines Part I
7.3 Metabolomic Analysis of Two Leukemia Cell Lines Part II
7.6 Isoenzymes in Cell Metabolic Pathways
7.7 A Brief Curation of Proteomics, Metabolomics, and Metabolism
7.8 Metabolomics is about Metabolic Systems Integration
7.9 Mechanisms of Drug Resistance
7.10 Development Of Super-Resolved Fluorescence Microscopy
7.11 Metabolic Reactions Need Just Enough
Chapter 8. Impairments in Pathological States: Endocrine Disorders; Stress Hypermetabolism and CAncer
8.1 Omega3 Fatty Acids, Depleting the Source, and Protein Insufficiency in Renal Disease
8.2 Liver Endoplasmic Reticulum Stress and Hepatosteatosis
8.3 How Methionine Imbalance with Sulfur Insufficiency Leads to Hyperhomocysteinemia
8.4 AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth InVivo
8.5 A Second Look at the Transthyretin Nutrition Inflammatory Conundrum
8.6 Mitochondrial Damage and Repair under Oxidative Stress
8.7 Metformin, Thyroid Pituitary Axis, Diabetes Mellitus, and Metabolism
8.8 Is the Warburg Effect the Cause or the Effect of Cancer: A 21st Century View?
8.9 Social Behavior Traits Embedded in Gene Expression
8.10 A Future for Plasma Metabolomics in Cardiovascular Disease Assessment
Chapter 9: Genomic Expression in Health and Disease
9.3 Metabolic Drivers in Aggressive Brain Tumors
9.4 Modified Yeast Produces a Range of Opiates for the First time
9.5 Parasitic Plant Strangleweed Injects Host With Over 9,000 RNA Transcripts
9.6 Plant-based Nutrition, Neutraceuticals and Alternative Medicine: Article Compilation the Journal
9.7 Reference Genes in the Human Gut Microbiome: The BGI Catalogue
9.8 Two Mutations, in the PCSK9 Gene: Eliminates a Protein involved in Controlling LDL Cholesterol
9.9 HDL-C: Target of Therapy – Steven E. Nissen, MD, MACC, Cleveland Clinic vs Peter Libby, MD, BWH
Summary
Epilogue
Leave a Reply