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Hybrid Imaging 3D Model of a Human Heart by Cardiac Imaging Techniques: CT and Echocardiography

Posted in 3D Printing for Medical Application, Artificial Vascular Structures, Cardiovascular and Vascular Systems, Cardiovascular Research, Cardiovascular Tissue, Frontiers in Cardiology and Cardiovascular Disorders, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound on August 3, 2015| Leave a Comment »

Hybrid Imaging 3D Model of a Human Heart by Cardiac Imaging Techniques: CT and Echocardiography

Reporter: Aviva Lev-Ari, PhD, RN

 

Group creates 3D printed heart with CT, echo data

By Eric Barnes, AuntMinnie.com staff writer

June 29, 2015 — In what they are calling a major advance, researchers from Michigan have created a 3D model of a human heart using data from two separate cardiac imaging techniques: CT and echocardiography. They believe that such hybrid 3D models will be more accurate than those created from just one imaging modality.

The study team from Spectrum Health Helen DeVos Children’s Hospital in Grand Rapids, MI, hailed the proof-of-concept study as the first use of hybrid imaging in the creation of a 3D heart.

3D image of heart model

3D image of heart model. Image courtesy of Spectrum Health.

Hybrid 3D printing integrates the best aspects of two or more imaging modalities, potentially enhancing diagnosis and improving interventional and surgical planning, said lead author Jordan Gosnell, a cardiac sonographer at the hospital. Previous 3D printing models used only a single modality, which is less accurate than merging two or more datasets.

The study also opens the way for hybrid 3D printing techniques to be used in combination with a third modality: cardiac MR, the study team said in a statement accompanying the results.

First, the researchers used software to register images from CT and 3D transesophageal echocardiography (TEE) scans; they then selectively integrated the datasets to produce the anatomic model of the heart. The results provide more detailed and anatomically accurate 3D renderings and printed models than are available from a single modality, which may allow clinicians to improve their diagnosis and treatment of heart disease.

Each imaging modality has different strengths, and combining the modalities leads to improved results, according to the researchers:

  • CT enhances the outside anatomy of the heart.
  • MRI is superior for the interior of the heart, including the right and left ventricles and the heart’s muscular tissue.
  • 3D TEE offers the best visualization of valve anatomy.

The work was presented at the 2015 Catheter Interventions in Congenital, Structural, and Valvular Heart Disease (CSI) meeting in Frankfurt, Germany, by study co-author Dr. Joseph Vettukattil, who has performed research with 3D and 4D echocardiography. Vettukattil developed the use of multiplanar reformatting (MPR) in echocardiography to evaluate complex heart defects.

“This is a huge leap for individualized medicine in cardiology and congenital heart disease,” Vettukattil said in the statement. “The technology could be beneficial to cardiologists and surgeons. The model will promote better diagnostic capability and improved interventional and surgical planning, which will help determine whether a condition can be treated via transcatheter route or if it requires surgery.”

Related Reading

3D printing from MRI untangles congenital heart surgery, November 21, 2014

Dassault unveils 3D virtual heart model, May 20, 2014

Researchers launch library of 3D heart models, April 18, 2013

Giant virtual reality chamber boosts 3D echo accuracy, August 2, 2007

 

SOURCE

http://www.auntminnie.com/index.aspx?Sec=sup&Sub=adv&Pag=dis&ItemId=111319

 

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Carotid ultrasound maximum plaque height: A sensitive imaging biomarker for the assessment of significant coronary artery disease

Posted in Echocardiography, Vascular Diseases on July 18, 2015| Leave a Comment »

Carotid ultrasound maximum plaque height: A sensitive imaging biomarker for the assessment of significant coronary artery disease

Reporter: Aviva Lev-Ari, PhD, RN

 

 

Echocardiography

Sourced through Scoop.it from: www.mdlinx.com

See on Scoop.it – Cardiovascular and vascular imaging

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Diffuse optics detects spinal cord ischemia – Optics.org

Posted in Circumferential-Intravascular-Radioluminescence-Photoacoustic-Imaging (CIRPI), Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound on May 7, 2015| Leave a Comment »

Diffuse optics detects spinal cord ischemia – Optics.org

Reporter: Aviva Lev-Ari, PhD, RN

 

 

 

Stony Brook Medicine probe measures both blood flow and oxygenation directly in real-time.

Source: optics.org

See on Scoop.it – Cardiovascular and vascular imaging

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Digital Imaging and Afirma gene expression classifier (GEC) tests: New Diagnostics in R&D by Veracyte and GE

Posted in Diagnostics and Lab Tests, Digital HealthCare – biotech & internet joint ventures, Genetics & Innovations in Treatment, Genome Biology, Image Processing/Computing, Imaging-based Cancer Patient Management, Medical Imaging Technology, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound on April 14, 2015| Leave a Comment »

Digital Imaging and Afirma gene expression classifier (GEC) tests: New Diagnostics in R&D by Veracyte and GE

Reporter: Aviva Lev-Ari, PhD, RN

Veracyte will collaborate with GE Ventures, GE Healthcare, and the GE Global Research Center

Apr 14, 2015

 

a GenomeWeb staff reporter

NEW YORK (GenomeWeb) – Veracyte today announced that it has signed a research collaboration agreement with GE to develop new diagnostic approaches based on GE Healthcare’s digital imaging technology.

The partners will “explore the concept of deriving innovative diagnostic approaches from a combination of digital imaging and genomic technologies,” Veracyte CEO Bonnie Anderson said in a statement.

The firms will look to identify features from raw imaging data that, when combined with genomic information, have the potential to inform disease diagnosis.

Veracyte has amassed a large database of clinical, imaging, and genomic information from clinical trials to validate its Afirma gene expression classifier (GEC) tests, the firm said in a statement.

Under the terms of the agreement, Veracyte will collaborate with GE Ventures, GE Healthcare, and the GE Global Research Center to assess the feasibility of combining the two firms’ technologies.

Financial and other terms of the agreement were not disclosed.

Last month, Veracyte expanded a co-promotion deal for the Afirma GEC test in Brazil and Singapore with Genzyme

 

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Blue Shield of California Issues Positive Coverage Policy for Veracyte’s Afirma GEC

 

 

SOURCE

https://www.genomeweb.com/molecular-diagnostics/veracyte-inks-research-collaboration-ge?utm_source=SilverpopMailing&utm_medium=email&utm_campaign=Daily%20News:%20Veracyte%20Inks%20Research%20Collaboration%20with%20GE%20-%2004/14/2015%2010:45:00%20AM

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3-D BioPrinting in use to create Cardiac Living Tissue: Print Your Heart Out

Posted in Frontiers in Cardiology and Cardiovascular Disorders, Medical Devices R&D Investment, Medical Imaging Technology, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound, Uncategorized on March 16, 2015| Leave a Comment »

3-D BioPrinting in use to create Cardiac Living Tissue: Print Your Heart Out

Reporter: Aviva Lev-Ari, PhD, RN

 

3rd International Conference on Tissue Engineering, ICTE2013

3D hybrid bioprinting of macrovascular structures

Can Kucukgula, Burce Ozlera, H. Ezgi Karakasb, Devrim Gozuacikb, Bahattin Koca*

aSabanci University, Manufacturing and Industrial Engineering, Faculty of Engineering and Naturel Sciences, Istanbul,34956, Turkey

bSabanci University, Bioengineering, Faculty of Engineering and Naturel Sciences, Istanbul,34956, Turkey

Abstract

Thousands of people die each year due the cardiovascular health problems. The most common treatments for cardiovascular health diseases are autografts and blood vessel transplantations which has limitations due to lack of donors and the patient’s conditions. Although there are several scaffold based studies about vascular tissue engineering, scaffold-based vascular grafts have some side effects including chronic inflammation, thrombosis and rejection after in-vivo implantation. Additionally, there are some problems with cell to cell interaction, the assembly and alignment of ECM components and the host response to scaffolds. Therefore, vascular tissue engineering studies tend towards scaffold- free techniques.

In this paper, novel computer aided algorithms and methods are developed for 3D printing of scaffold-free macrovascular structures. An example aorta model is generated using imaging and segmentation software. The developed algorithms are implemented using Rhinoscript. In order to support printed cell aggregates, support structures with ‘Cake’ and ‘Zigzag’ patterns are developed and 3D printed.

© 2013 The Authors. Published by Elsevier Ltd. Open access under CC BY-NC-ND license.

Selection and peer-review under responsibility of the Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Centro Empresarial da Marinha Grande.

Keywords: scaffold free vascular tissue engineering, computer aided biomodeling, 3D bioprinting , hybrid cell-biomaterial printing.

* Corresponding author. Tel.: +90-216-4839557; fax: +90-216-483-9550.

E-mail address: bahattıinkoc@sabanciuniv.edu

SOURCE

© 2013 The Authors. Published by Elsevier Ltd. Open access under CC BY-NC-ND license.

Print Your Heart Out

3-D bioprinting can already create living tissue, but it’s unclear whether it will ever replicate organs
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Materials SCENE, Organic SCENE
Keywords: Bioprint, 3-D print, organ, tissue, engineering
Disappearing Ink
C&EN takes a look inside Jennifer Lewis’s lab to see her team’s technique for 3-D printing tissue with artificial blood vessels.
Credit: Matt Davenport/C&EN/Adv. Mater.

VIEW VIDEO

http://cen.acs.org/articles/93/i10/Print-Heart.html?h=-265035111 

It was an honest question. But the way Stuart K. Williams asked it sounded like the prelude to a wager: Which organ will researchers first replicate with three-dimensional bioprinting?

Williams, the director of the Bioficial Organs Program at the University of Louisville, posed the question to Gabor Forgacs of the University of Missouri at last month’s Select Biosciences Tissue Engineering & Bioprinting Conference in Boston. Forgacs, having just delivered the keynote speech, mulled the question over.

Some believe 3-D printers will one day create viable organ transplants using a patient’s own cells. This would alleviate complications that arise when a patient’s immune system rejects a donor organ. And it would put an end to growing transplant wait lists. For every organ donor in 2012, there were more than eight patients on the transplant wait list, according to the U.S. Department of Health & Human Services.

Williams’s question hung in the air for a moment. The conference hall overlooking the Charles River was packed even though the latest in a series of record-setting snowstorms kept many would-be attendees away. The crowd waited silently for Forgacs’s answer, but everyone there had an inkling of what it would be.

Forgacs, a pioneer in bioengineering who’s printed 3-D structures with “inks” made of living cells, hedged the question, reminding the audience of comments he made during his talk. “Everybody’s dream is the 3-D printed organ. Are we ever going to get there?” he asked himself. “I’m not so sure.”

Bioprinting’s more immediate impact will be in making small patches of tissue for screening drugs or for better understanding biology, Forgacs said. Before researchers can even hope to tackle the far more complex problem of printing an entire organ, he added, they will need to confront some daunting challenges, such as figuring out how to print blood vessels capable of supplying artificial organs with essential nutrients.

[+]Enlarge

09310-scitech1-Livertissuecxd

LIVER DELIVERY
Organovo’s 3-D printed liver tissue contains three different types of cells. The dominant cells, stained blue, are roughly 20 μm in diameter.
Credit: Organovo

These challenges influence the decisions researchers make in every phase of the printing process: from concocting a suitable bioink to printing the ink to goading the printed cells to act like an organ. This last bit, Forgacs said, is the most important and most difficult challenge.

He’s not convinced that researchers will ever duplicate an organ with bioprinting, but he doesn’t believe that they should try to copy organs exactly. “There’s no reason we can’t make something that functions exactly the same, if not better, than the natural organ,” Forgacs told C&EN. The day when an improved heart or liver can be printed on demand is several decades away, but Forgacs is optimistic it’s coming. “We are fantastic engineers.”

Researchers’ engineering ingenuity is evidenced by how far bioprinting has come since its birth about 15 years ago. It’s tough to pin down an exact starting point for the field, but many researchers point to the early-2000s work of Thomas Boland, who was then working as a bioengineer at Clemson University.

Boland swapped out the contents of an ink-jet printer cartridge for a bioink containing bovine cells suspended in a mixture of serum and cell-culture medium. After installing the cartridge in a modified Hewlett-Packard desktop printer, his team printed a 2-D pattern of the ink on a biopaper—a substrate that makes cells feel more at home outside the body. In this case, the biopaper was a gelatinous mixture of collagen and a protein matrix to help anchor cells. Within a few years, the ink-jet technology could print stacks of these cellular patterns to make 3-D structures.

Boland’s experiments would essentially define the criteria needed for a method to truly be considered bioprinting. First, the bioink must contain cells. Metals, plastics, and ceramics have been printed without cells to repair or replace biological structures such as teeth, windpipes, and skulls. Many consider these uses to be examples of conventional 3-D printing with biological applications rather than bioprinting.

Second, the bioprinter must be able to pattern a user-defined 3-D structure on demand. This means that organs made from cells cultured in molds don’t get the “bioprinted” label. This method has been used by researchers at Wake Forest University toproduce bladders for transplantation.

And finally, the cells must survive the printing process and remain viable. In other words, a printer shouldn’t murder cells with heat, laser light, or mechanical stress. Cells also need a print medium that fosters a nurturing biological environment, which can be provided by the bioink, the biopaper, or some combination thereof.

Since Boland’s ink-jet innovation, researchers have developed a variety of inks, papers, and printers that work together to satisfy the basic requirements of bioprinting. Some of these products have even been commercialized.

There are currently more than a dozen 3-D bioprinting companies, according to a list provided by Select Biosciences.Organovo, a company founded in 2007 based on technology developed by Forgacs, is the most notable among these, according to many in the field.

In November of last year, Organovo started selling a 3-D bioprinted liver tissue called exVive3D. The tissue accurately predicts human response to drugs that are toxic to the liver, according to the company’s chief executive officer, Keith Murphy.

Pharmaceutical companies could thus use the tissue to test drugs at a stage between preclinical animal trials and clinical human trials. Catching adverse effects in human tissue before moving a drug into clinical trials would not only better protect patients but also save companies time and money in drug development.

So far, the response to the exVive product has been good, Murphy said. The printed tissue accounted for nearly $140,000 of Organovo’s revenue between its November launch date and the end of the calendar year, according to the company’s most recent quarterly report.

Continue Reading

SOURCE

http://cen.acs.org/articles/93/i10/Print-Heart.html?h=-265035111

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Aortic Valve Area Calculation in Aortic Stenosis by CT and Doppler Echocardiography

Posted in Aortic Valve: TAVR, TAVI vs Open Heart Surgery, Cardiac and Cardiovascular Surgical Procedures, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound on March 12, 2015| Leave a Comment »

Aortic Valve Area Calculation in Aortic Stenosis by CT and Doppler Echocardiography

Reporter: Aviva Lev-Ari, PhD, RN

MA Clavel, J Malouf, D Messika-Zeitoun, PA Araoz, HI Michelena, M Enriquez-Sarano.
J Am Coll Cardiol Img. 2015; 8(3):248-257.

Abstract

Objectives

The aim of this study was to verify the hypothesis that multidetector computed tomography (MDCT) is superior to echocardiography for measuring the left ventricular outflow tract (LVOT) and calculating the aortic valve area (AVA) with regard to hemodynamic correlations and survival outcome prediction after a diagnosis of aortic stenosis (AS).

Background

MDCT demonstrated that the LVOT is noncircular, casting doubt on the AVA measurement by 2-dimensional (2D) echocardiography.

Methods

A total of 269 patients (76 ± 11 years of age, 61% men) with isolated calcific AS (mean gradient 44 ± 18 mm Hg; ejection fraction 58 ± 15%) underwent Doppler echocardiography and MDCT within the same episode of care. AVA was calculated by echocardiography (AVAEcho) and by MDCT (AVACT) using each technique measurement of LVOT area. In the subset of patients undergoing dynamic 4-dimensional MDCT (n = 135), AVA was calculated with the LVOT measured at 70% and 20% of the R-R interval and measured by planimetry (AVAPlani).

Results

Phasic measurements of the LVOT by MDCT yielded slight differences in eccentricity and size (all p < 0.001) but with excellent AVA correlation (r = 0.92, p < 0.0001) and minimal bias (0.05 cm2), whereas the AVAPlani showed poor correlations with all other methods (all r values <0.58). AVACT was larger than AVAEcho (difference 0.12 ± 0.16 cm2; p < 0.0001) but did not improve outcome prediction. Correlation gradient-AVA was slightly better with AVAEcho than AVACT (r = −0.65 with AVAEcho vs. −0.61 with AVACT; p = 0.01), and discordant gradient-AVA was not reduced. For long-term survival, after multivariable adjustment, AVAEcho or AVACT were independently predictive (hazard ratio [HR]: 1.26, 95% confidence interval [CI]: 1.13 to 1.42; p < 0.0001 or HR: 1.18, 95% CI: 1.09 to 1.29 per 0.10 cm2 decrease; p < 0.0001) with a similar prognostic value (p ≥ 0.80). Thresholds for excess mortality differed between methods: AVAEcho ≤1.0 cm2 (HR: 4.67, 95% CI: 2.22 to 10.50; p < 0.0001) versus AVACT ≤1.2 cm2 (HR: 3.16, 95% CI: 1.64 to 6.43; p = 0.005), with simple translation of spline-curve analysis.

Conclusions

Head-to-head comparison of MDCT and Doppler echocardiography refutes the hypothesis of MDCT superiority for AVA calculation. AVACT is larger than AVAEcho but does not improve the correlation with transvalvular gradient, the concordance gradient-AVA, or mortality prediction compared with AVAEcho. Larger cut-point values should be used for severe AS if AVACT (<1.2 cm2) is measured versus AVAEcho (<1.0 cm2).

Source: www.thepreparedminds.com

See on Scoop.it – Cardiovascular and vascular imaging

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Americare Neurosurgery International Inc & Relief International: Fund Raising Campaign for bringing Medical Equipment to Hospitals in Myanmar

Posted in Medical Imaging Technology, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound on February 12, 2015| Leave a Comment »

Americare Neurosurgery International Inc & Relief International: Fund Raising Campaign for bringing Medical Equipment to Hospitals in Myanmar

Reporter: Aviva Lev-Ari, PhD, RN

 

At the request of Gary Heit Ph.D. M.D., Co-founder and Medical Director Americare Neurosurgery International Inc – a 501.c.3

 

Welcome to the online funding event for Americare’s new program in Myanmar and to continue our work in Hue University, Vietnam. Our mission, in conjunction with Relief International, is to bring the contents of a modern western hospital to a medical centers in Sittwe and Mrauk Oo, Myanmar and then train the local healthcare providers in it’s use. These regional hospital in northwestern Myanmar are mostly empty, and have less capacity then a US urgent care center.

Please, if you can make a donation of any size to the campaign ($20-100-1,000,10,000!), but more importantly, send this link out to your friends in the hopes of it going viral, we would be deeply indebted.

http://www.gofundme.com/huwurw

You can learn more about us on our Facebook page:

https://www.facebook.com/pages/Americare-Neurosurgery-International/322939084578390?ref=aymt_homepage_panel

Thank you in advance for your generosity and help. And I thank you on behalf of the tens of thousands of people in Sittwe, Mrauk Oo, central Vietnam and the surrounding countrysides who will benefit from you generosity for years to come.

Think globally, act locally.

Gary

Gary Heit Ph.D.M.D.

Co-founder and Medical Director

Americare Neurosurgery International Inc – a 501.c.3

 

I am writing to ask for your creative help on a fund raising project. View the two short video clips, and you will understand why I am so driven.

Kaiser hospital donated a used scanner to Mynmar, but funds need to be raised to have it shipped.
No donation is too small. We conducted an inventory of donated equipment last Saturday, which some will go to Mynmar and some to Vietnam.

I, would more than appreciate any help, guidance insight, or support. This will be Gary’s last project and I want it to get funded as quickly as possible. I have never known anyone as compassionate and generous as Dr. Heit.

Gary did set up a go fund site, but people are not responding. Reality is the overwhelming majority of Americans don’t even know where Mynmar is, nor do they know what real poverty looks like.

Asking for your help, as I am terrible at any social media !

Once you see these video’s you will understand why I am reaching out to everyone.

Below are 2 short video clips about Dr. Gary Heit, and attached is the information about the Fund Raising.

 

https://www.youtube.com/watch?v=u0LoG6xTRc8

Uploaded on Oct 22, 2007

At UC Santa Cruz’s 2007 Founders Day dinner, Dr. Gary Heit was presented with the Alumni Association’s 2007-08 Alumni Achievement Award. Dr. Heit, honored for his “neurological work developing Deep Brain Stimulation and for his humanitarian work in the medical field,” is the subject of this video tribute.

https://www.youtube.com/watch?v=evtoET656ZE

Look forward to your assistance or guidance.

Kind Regards,

Marguerite McHenry
650-366-1706 Office
650-842-0122 Cell

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RSNA 2014 Editor’s Choice of the Most Innovative New Technology

Posted in CT, FDA Regulatory Affairs, Medical Devices R&D Investment, Medical Imaging Technology, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound on January 13, 2015| Leave a Comment »

RSNA 2014 Editor’s Choice of the Most Innovative New Technology

Reporter: Aviva Lev-Ari, PhD, RN

 

Here are ITN Editor Dave Fornell’s choices for the most innovative new imaging technologies shown on the expo floor at the Radiological Society of North America (RSNA) 2014 annual meeting.

VIEW VIDEO

http://www.itnonline.com/view-all/videos?bclid=910141019001&bctid=3938820152001

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Dynamic myocardial CT perfusion imaging for evaluation of myocardial ischemia as determined by MR imaging | DSCT.com – Your Dual-source CT experts

Posted in Frontiers in Cardiology and Cardiovascular Disorders, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound, MRI, Myocardial metabolism, Myocardial ischemia, myocardial perfusion, Myocardial adenine nucleotide metabolism, Noninvasive Diagnostic Fractional Flow Reserve (FFR) CT on December 15, 2014| Leave a Comment »

Dynamic myocardial CT perfusion imaging for evaluation of myocardial ischemia as determined by MR imaging | DSCT.com – Your Dual-source CT experts

Reporter: Aviva Lev-Ari, PhD, RN

 

 

 

The aim of this study was to determine the feasibility of CT-based dynamic myocardial perfusion imaging for the assessment of myocardial ischemia and infarction compared with cardiac magnetic resonance (CMR).

Source: www.dsct.com

See on Scoop.it – Cardiovascular and vascular imaging

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Integrating laser diode and ultrasound transducer array to build compact medical imaging device

Posted in Medical Devices R&D Investment, Medical Imaging Technology, Medical Imaging Technology, Image Processing/Computing, MRI, CT, Nuclear Medicine, Ultra Sound on October 24, 2014| Leave a Comment »

Integrating laser diode and ultrasound transducer array to build compact medical imaging device

Reporter: Aviva Lev-Ari, PhD, RN

 

 

 

Scientists at the MIRA research institute, in collaboration with various companies, have developed a prototype of a handy device that combines echoscopy (ultrasound) with photoacoustics. Combining these two medical imaging technologies in a compact device is designed, among other things, to enable the amount of inflammation in rheumatic patients’ joints to be measured more simply and precisely. The researchers expect that the technology will eventually also be able to play a role in detecting the severity of burns, skin cancer and furring of the arteries. The prototype is presented in the scientific journal Optics Express.

 

Echoscopy and photoacoustics are complementary medical imaging technologies. Photoacoustics involves sending brief laser pulses into the patient’s body. When the laser light hits a blood vessel, for example, it is locally converted into heat, which causes a minor rise in pressure. This propagates through the body like a sound wave and can then be measured on the skin. Echoscopy involves sending ultrasound waves into the body: different tissues reflect them in different ways, and they too can then be detected on the skin. Whereas echoscopy provides an image of structures, photoacoustics can provide an image containing more functional information, such as the presence of blood.

Source: phys.org

See on Scoop.it – Cardiovascular and vascular imaging

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