Breast Cancer and Mitochondrial Mutations
Author: Larry H Bernstein, MD, FCAP
Word Cloud By Danielle Smolyar
How Aggressive Breast Tumors and Mitochondrial Mutations Are Linked
Mitochondrial complex I critically determines the energy output of cellular respiration. The Felding team discovered that the balance of key metabolic cofactors processed by complex I—specifically,
- nicotinamide adenine dinucleotide (NAD+) and NADH,
- was disturbed in aggressive breast cancer cells.
The team altered genes tied to NAD+ production. The resulting shift again showed that
- higher NADH levels meant more aggressive tumors,
- while increased NAD+ had the opposite effect.
Related articles
misshapen chemo drug particles may be better at targeting breast cancer (fiercebiotechresearch.com)
Key Enzyme Missing From Triple-Negative Breast Cancer (medicalnewstoday.com)