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Breast Cancer and Mitochondrial Mutations

Author: Larry H Bernstein, MD, FCAP

How Aggressive Breast Tumors and Mitochondrial Mutations Are Linked

Feb 18, 2013  Brunhilde H. Felding, Ph.D., Scripps Research Institute (TSRI)
Mitochondrial complex I critically determines the energy output of cellular respiration. The Felding team discovered that the balance of key metabolic cofactors processed by complex I—specifically,
the form it takes after accepting a key electron in the energy production cycle—

The team altered genes tied to NAD+ production. The resulting shift again showed that

  • higher NADH levels meant more aggressive tumors,
  • while increased NAD+ had the opposite effect.
The scientists found that enhancing the NAD+/NADH balance through the nicotinamide treatment inhibited metastasis, and the mice lived longer.
Reduction and oxidation of the NAD. Created us...

Reduction and oxidation of the NAD. Created using ACD/ChemSketch 10.0 and . (Photo credit: Wikipedia)

Comparison of the absorbance spectra of NAD+ a...

Comparison of the absorbance spectra of NAD+ and NADH (Photo credit: Wikipedia)

English: By Richard Wheeler (Zephyris) 2006. T...

English: By Richard Wheeler (Zephyris) 2006. The structure of the peripheral domain of an NADH dehydrogenase (mitochondrial complex I) related protein; bacterial FMN dehygrogenase PDB 2FUG. (Photo credit: Wikipedia)

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